ALG11

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a GDP-Man:Man3GlcNAc2-PP-dolichol-alpha1,2-mannosyltransferase which is localized to the cytosolic side of the endoplasmic reticulum (ER) and catalyzes the transfer of the fourth and fifth mannose residue from GDP-mannose (GDP-Man) to Man3GlcNAc2-PP-dolichol and Man4GlcNAc2-PP-dolichol resulting in the production of Man5GlcNAc2-PP-dolichol. Mutations in this gene are associated with congenital disorder of glycosylation type Ip (CDGIP). This gene overlaps but is distinct from the UTP14, U3 small nucleolar ribonucleoprotein, homolog C (yeast) gene. A pseudogene of the GDP-Man:Man3GlcNAc2-PP-dolichol-alpha1,2-mannosyltransferase has been identified on chromosome 19. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1presynaptic membrane assembly (GO:0097105)5.23180109
2GMP metabolic process (GO:0046037)4.74588204
3indole-containing compound catabolic process (GO:0042436)4.61000340
4indolalkylamine catabolic process (GO:0046218)4.61000340
5tryptophan catabolic process (GO:0006569)4.61000340
6postsynaptic membrane organization (GO:0001941)4.58937931
7indolalkylamine metabolic process (GO:0006586)4.47345217
8kynurenine metabolic process (GO:0070189)4.40416896
9presynaptic membrane organization (GO:0097090)4.22015076
10respiratory chain complex IV assembly (GO:0008535)4.16801565
11detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)4.12931652
12intraciliary transport (GO:0042073)4.10157708
13behavioral response to nicotine (GO:0035095)4.00712155
14tryptophan metabolic process (GO:0006568)3.93837607
15neural tube formation (GO:0001841)3.92533022
16mesenchymal cell differentiation involved in kidney development (GO:0072161)3.90866777
17mesenchymal cell differentiation involved in renal system development (GO:2001012)3.90866777
18L-fucose catabolic process (GO:0042355)3.90069220
19fucose catabolic process (GO:0019317)3.90069220
20L-fucose metabolic process (GO:0042354)3.90069220
21facial nerve structural organization (GO:0021612)3.88672221
22positive regulation of developmental pigmentation (GO:0048087)3.84458007
23cell differentiation involved in metanephros development (GO:0072202)3.79782036
24cytochrome complex assembly (GO:0017004)3.74811352
25negative regulation of keratinocyte proliferation (GO:0010839)3.73470393
26negative regulation of dendrite morphogenesis (GO:0050774)3.70657912
27signal peptide processing (GO:0006465)3.64302425
28positive regulation of mitochondrial fission (GO:0090141)3.60730200
29startle response (GO:0001964)3.53457748
30DNA ligation (GO:0006266)3.53156134
31regulation of hippo signaling (GO:0035330)3.53042224
32polyketide metabolic process (GO:0030638)3.49254486
33doxorubicin metabolic process (GO:0044598)3.49254486
34daunorubicin metabolic process (GO:0044597)3.49254486
35regulation of pigment cell differentiation (GO:0050932)3.48092654
36cullin deneddylation (GO:0010388)3.41811093
37dopamine transport (GO:0015872)3.37351319
38viral protein processing (GO:0019082)3.33127087
39cranial nerve structural organization (GO:0021604)3.29589927
40detection of light stimulus involved in visual perception (GO:0050908)3.28536065
41detection of light stimulus involved in sensory perception (GO:0050962)3.28536065
42* mannosylation (GO:0097502)3.26146346
43cellular biogenic amine catabolic process (GO:0042402)3.25919188
44amine catabolic process (GO:0009310)3.25919188
45cellular ketone body metabolic process (GO:0046950)3.23734480
46regulation of rhodopsin mediated signaling pathway (GO:0022400)3.20188791
47sympathetic nervous system development (GO:0048485)3.19191929
48indole-containing compound metabolic process (GO:0042430)3.17407904
49androgen biosynthetic process (GO:0006702)3.16652444
50protein localization to cilium (GO:0061512)3.15804745
51proteasome assembly (GO:0043248)3.15739579
52double-strand break repair via homologous recombination (GO:0000724)3.15664192
53prenylation (GO:0097354)3.15638768
54protein prenylation (GO:0018342)3.15638768
55recombinational repair (GO:0000725)3.15489231
56DNA double-strand break processing (GO:0000729)3.14675730
57protein complex biogenesis (GO:0070271)3.14038994
58positive regulation of protein homodimerization activity (GO:0090073)3.10964445
59monoubiquitinated protein deubiquitination (GO:0035520)3.10174267
60centriole replication (GO:0007099)3.09091242
61regulation of meiosis I (GO:0060631)3.09036623
62DNA deamination (GO:0045006)3.08347219
63negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.04740919
64negative regulation of translation, ncRNA-mediated (GO:0040033)3.04740919
65regulation of translation, ncRNA-mediated (GO:0045974)3.04740919
66reflex (GO:0060004)3.04354757
67mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.04269009
68mitochondrial respiratory chain complex I assembly (GO:0032981)3.04269009
69NADH dehydrogenase complex assembly (GO:0010257)3.04269009
70response to pheromone (GO:0019236)3.04187631
71ER overload response (GO:0006983)3.02483988
72rhodopsin mediated signaling pathway (GO:0016056)3.02240964
73photoreceptor cell maintenance (GO:0045494)3.01902580
74negative regulation of cytosolic calcium ion concentration (GO:0051481)3.01304269
75chondrocyte proliferation (GO:0035988)2.98002183
76platelet dense granule organization (GO:0060155)2.97979614
77behavioral response to ethanol (GO:0048149)2.97646270
78retinal cone cell development (GO:0046549)2.96641949
79ketone body metabolic process (GO:1902224)2.95460279
80protein deneddylation (GO:0000338)2.95405958
81negative regulation of DNA-dependent DNA replication (GO:2000104)2.94341782
82cilium or flagellum-dependent cell motility (GO:0001539)2.94019249
83protein K11-linked deubiquitination (GO:0035871)2.92871624
84cell differentiation involved in kidney development (GO:0061005)2.92459400
85mesonephros development (GO:0001823)2.92267797
86regulation of gene silencing by miRNA (GO:0060964)2.91793068
87regulation of gene silencing by RNA (GO:0060966)2.91793068
88regulation of posttranscriptional gene silencing (GO:0060147)2.91793068
89nucleotide transmembrane transport (GO:1901679)2.90923859
90deoxyribose phosphate biosynthetic process (GO:0046385)2.90315638
912-deoxyribonucleotide biosynthetic process (GO:0009265)2.90315638
92epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.89690110
93cilium morphogenesis (GO:0060271)2.87985276
94developmental pigmentation (GO:0048066)2.87465723
95negative regulation of norepinephrine secretion (GO:0010700)2.85299480
96appendage development (GO:0048736)2.84579503
97limb development (GO:0060173)2.84579503
98short-term memory (GO:0007614)2.84488158
99DNA methylation involved in gamete generation (GO:0043046)2.84217534
100N-acetylglucosamine metabolic process (GO:0006044)2.83864535
101replication fork processing (GO:0031297)2.82885547
102sphingoid metabolic process (GO:0046519)2.82063700
103negative regulation of dendrite development (GO:2000171)2.82033420
104nonmotile primary cilium assembly (GO:0035058)2.81253194
105omega-hydroxylase P450 pathway (GO:0097267)2.81161568
106benzene-containing compound metabolic process (GO:0042537)2.80641729
107establishment of protein localization to Golgi (GO:0072600)2.80519816
108aromatic amino acid family catabolic process (GO:0009074)2.77906315
109tachykinin receptor signaling pathway (GO:0007217)2.76954475
110piRNA metabolic process (GO:0034587)2.75884370
111reciprocal DNA recombination (GO:0035825)2.75714560
112reciprocal meiotic recombination (GO:0007131)2.75714560
113terpenoid biosynthetic process (GO:0016114)2.75566969
114extracellular negative regulation of signal transduction (GO:1900116)2.74116525
115extracellular regulation of signal transduction (GO:1900115)2.74116525
116protein-cofactor linkage (GO:0018065)2.71633783
117adenosine metabolic process (GO:0046085)2.71053939
118cilium organization (GO:0044782)2.70995716
119water-soluble vitamin biosynthetic process (GO:0042364)2.69962639
120guanosine-containing compound biosynthetic process (GO:1901070)2.69748620
121L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.68806298
122anterograde synaptic vesicle transport (GO:0048490)2.68178545
123gamma-aminobutyric acid transport (GO:0015812)2.67956131
124preassembly of GPI anchor in ER membrane (GO:0016254)2.67398885
125deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.64978105
126regulation of nuclear cell cycle DNA replication (GO:0033262)2.63107066
127eye photoreceptor cell development (GO:0042462)2.62252660
128retina layer formation (GO:0010842)2.62080528
129inositol phosphate catabolic process (GO:0071545)2.61834424
130oxidative demethylation (GO:0070989)2.61649465
131DNA demethylation (GO:0080111)2.61239963
132sulfation (GO:0051923)2.60580991
133mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.60512814
134cellular response to sterol (GO:0036315)2.59956383
135regulation of sarcomere organization (GO:0060297)2.59463022
136RNA-dependent DNA replication (GO:0006278)2.58759841
137epithelial cilium movement (GO:0003351)2.58736267
138kidney morphogenesis (GO:0060993)2.58117917
139chaperone-mediated protein transport (GO:0072321)2.58099931
140mitochondrial respiratory chain complex assembly (GO:0033108)2.58086428
141phasic smooth muscle contraction (GO:0014821)2.57609816
142diterpenoid biosynthetic process (GO:0016102)2.56929771
143detection of mechanical stimulus involved in sensory perception (GO:0050974)2.56127683
144photoreceptor cell development (GO:0042461)2.53335788
145regulation of mitotic spindle checkpoint (GO:1903504)2.52716279
146regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.52716279
147dentate gyrus development (GO:0021542)2.52388485
148purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)2.50268536
149RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.49687619
150negative regulation of stem cell proliferation (GO:2000647)2.49212990
151microtubule anchoring (GO:0034453)2.49164455
152NAD biosynthetic process (GO:0009435)2.48845351
153neuron cell-cell adhesion (GO:0007158)2.48067061
154G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.47166636
155aromatic amino acid family metabolic process (GO:0009072)2.47146104
156spinal cord motor neuron differentiation (GO:0021522)2.46203582
157neuronal action potential (GO:0019228)2.46079152
158serotonin receptor signaling pathway (GO:0007210)2.45630789
159histamine secretion (GO:0001821)2.45466703
160glucosamine-containing compound metabolic process (GO:1901071)2.44259278
161generation of neurons (GO:0048699)2.44086782
162regulation of male gonad development (GO:2000018)2.43148040
163cilium assembly (GO:0042384)2.42847152
164transcription elongation from RNA polymerase III promoter (GO:0006385)2.41400352
165termination of RNA polymerase III transcription (GO:0006386)2.41400352
166regulation of hexokinase activity (GO:1903299)2.41369455
167regulation of glucokinase activity (GO:0033131)2.41369455
168neurotransmitter-gated ion channel clustering (GO:0072578)2.39293990
169positive regulation of protein sumoylation (GO:0033235)2.38824631
170purine nucleobase biosynthetic process (GO:0009113)2.38552268
171urinary tract smooth muscle contraction (GO:0014848)2.38044854
172mechanosensory behavior (GO:0007638)2.37711332
173mesenchymal cell differentiation (GO:0048762)2.37620933
174neurotransmitter uptake (GO:0001504)2.37088888
175deoxyribonucleoside diphosphate metabolic process (GO:0009186)2.34722107
176metanephric mesenchyme development (GO:0072075)2.34071610
177RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.33902963
178tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.33902963
179negative regulation of mast cell activation (GO:0033004)2.33427579
180negative regulation of myoblast differentiation (GO:0045662)2.32906236
181deoxyribonucleotide biosynthetic process (GO:0009263)2.32884021
182axoneme assembly (GO:0035082)2.32628538

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human4.13826921
2RBPJ_22232070_ChIP-Seq_NCS_Mouse3.52383433
3ZNF274_21170338_ChIP-Seq_K562_Hela3.41263294
4HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.38451961
5EZH2_22144423_ChIP-Seq_EOC_Human2.96523782
6TAF15_26573619_Chip-Seq_HEK293_Human2.87600258
7ZFP57_27257070_Chip-Seq_ESCs_Mouse2.86900296
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.74375437
9POU3F2_20337985_ChIP-ChIP_501MEL_Human2.67094086
10FLI1_27457419_Chip-Seq_LIVER_Mouse2.38715388
11* BMI1_23680149_ChIP-Seq_NPCS_Mouse2.34320568
12PCGF2_27294783_Chip-Seq_ESCs_Mouse2.30425687
13P300_19829295_ChIP-Seq_ESCs_Human2.21045053
14FUS_26573619_Chip-Seq_HEK293_Human2.15763850
15CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.04446868
16SALL1_21062744_ChIP-ChIP_HESCs_Human2.02955848
17TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.99245401
18CBX2_27304074_Chip-Seq_ESCs_Mouse1.95309906
19EWS_26573619_Chip-Seq_HEK293_Human1.92839324
20FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.90262712
21RNF2_27304074_Chip-Seq_NSC_Mouse1.88848607
22GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.88140718
23* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.88123706
24IRF1_19129219_ChIP-ChIP_H3396_Human1.86379658
25POU5F1_16153702_ChIP-ChIP_HESCs_Human1.83041913
26CTBP2_25329375_ChIP-Seq_LNCAP_Human1.79641759
27SUZ12_27294783_Chip-Seq_NPCs_Mouse1.79159287
28BCAT_22108803_ChIP-Seq_LS180_Human1.73289408
29NFE2_27457419_Chip-Seq_LIVER_Mouse1.68977809
30VDR_22108803_ChIP-Seq_LS180_Human1.67847892
31NANOG_18555785_Chip-Seq_ESCs_Mouse1.65590992
32ELF1_17652178_ChIP-ChIP_JURKAT_Human1.65110039
33EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.64578291
34PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.63052815
35HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.61083124
36* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.60640070
37CBP_20019798_ChIP-Seq_JUKART_Human1.60380604
38IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.60380604
39EED_16625203_ChIP-ChIP_MESCs_Mouse1.60235202
40ER_23166858_ChIP-Seq_MCF-7_Human1.60196347
41CTBP1_25329375_ChIP-Seq_LNCAP_Human1.59453572
42P53_22387025_ChIP-Seq_ESCs_Mouse1.58532640
43BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.57574048
44IGF1R_20145208_ChIP-Seq_DFB_Human1.56277305
45SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.55763779
46SMAD4_21799915_ChIP-Seq_A2780_Human1.55389847
47EZH2_27294783_Chip-Seq_NPCs_Mouse1.54822506
48STAT3_18555785_Chip-Seq_ESCs_Mouse1.54480225
49TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.53679090
50E2F1_18555785_Chip-Seq_ESCs_Mouse1.53515434
51SUZ12_18555785_Chip-Seq_ESCs_Mouse1.53085421
52NR3C1_21868756_ChIP-Seq_MCF10A_Human1.48778753
53TOP2B_26459242_ChIP-Seq_MCF-7_Human1.48650510
54NOTCH1_21737748_ChIP-Seq_TLL_Human1.47233077
55NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.46775401
56MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.46562271
57P300_18555785_Chip-Seq_ESCs_Mouse1.46455688
58EZH2_27304074_Chip-Seq_ESCs_Mouse1.46408289
59PIAS1_25552417_ChIP-Seq_VCAP_Human1.46101272
60EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.44591784
61OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.43768922
62PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.42866897
63FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.42484730
64EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.40650061
65TCF4_22108803_ChIP-Seq_LS180_Human1.40295449
66RUNX1_27457419_Chip-Seq_LIVER_Mouse1.40215418
67PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.39824396
68CMYC_18555785_Chip-Seq_ESCs_Mouse1.39671365
69RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.39570146
70PCGF2_27294783_Chip-Seq_NPCs_Mouse1.39286824
71TAL1_26923725_Chip-Seq_HPCs_Mouse1.37477113
72JARID2_20064375_ChIP-Seq_MESCs_Mouse1.37269288
73POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.36225353
74TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.36225353
75NMYC_18555785_Chip-Seq_ESCs_Mouse1.35550340
76RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.34755399
77SOX2_18555785_Chip-Seq_ESCs_Mouse1.34132540
78SOX2_19829295_ChIP-Seq_ESCs_Human1.34117329
79NANOG_19829295_ChIP-Seq_ESCs_Human1.34117329
80SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.33950188
81RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.32471616
82NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.32470935
83TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.30668873
84SMAD3_21741376_ChIP-Seq_EPCs_Human1.30542872
85* SRF_21415370_ChIP-Seq_HL-1_Mouse1.30371608
86AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.29612071
87ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.28314365
88OCT4_18555785_Chip-Seq_ESCs_Mouse1.27980499
89* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.27946230
90SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.27895567
91CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.27770672
92CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27567816
93TP53_22573176_ChIP-Seq_HFKS_Human1.26086437
94KLF5_20875108_ChIP-Seq_MESCs_Mouse1.25902632
95WT1_19549856_ChIP-ChIP_CCG9911_Human1.25882635
96SMAD_19615063_ChIP-ChIP_OVARY_Human1.24146758
97EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.23362096
98CDX2_22108803_ChIP-Seq_LS180_Human1.21255388
99GABP_17652178_ChIP-ChIP_JURKAT_Human1.20672841
100PRDM14_20953172_ChIP-Seq_ESCs_Human1.19360487
101FLI1_21867929_ChIP-Seq_TH2_Mouse1.18885914
102SMAD4_21741376_ChIP-Seq_EPCs_Human1.18619989
103SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.17691203
104JUN_21703547_ChIP-Seq_K562_Human1.17524383
105SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.17447555
106HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.16840304
107ZFX_18555785_Chip-Seq_ESCs_Mouse1.15474046
108SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.15224532
109CRX_20693478_ChIP-Seq_RETINA_Mouse1.13958076
110UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.13763162
111SMAD1_18555785_Chip-Seq_ESCs_Mouse1.13379910
112FOXA1_25329375_ChIP-Seq_VCAP_Human1.12852713
113FOXA1_27270436_Chip-Seq_PROSTATE_Human1.12852713
114AR_25329375_ChIP-Seq_VCAP_Human1.12573096
115GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.12531758
116PU1_27457419_Chip-Seq_LIVER_Mouse1.12466033
117EST1_17652178_ChIP-ChIP_JURKAT_Human1.12285813
118KLF4_18555785_Chip-Seq_ESCs_Mouse1.11785523
119RUNX2_22187159_ChIP-Seq_PCA_Human1.11486050
120FOXA1_21572438_ChIP-Seq_LNCaP_Human1.10996702
121TCF4_23295773_ChIP-Seq_U87_Human1.09633867
122CTCF_18555785_Chip-Seq_ESCs_Mouse1.09496062
123MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.08718184
124JARID2_20075857_ChIP-Seq_MESCs_Mouse1.08042968
125ELK1_19687146_ChIP-ChIP_HELA_Human1.07913373
126OCT4_21477851_ChIP-Seq_ESCs_Mouse1.07133090
127AR_21572438_ChIP-Seq_LNCaP_Human1.06933902
128KDM2B_26808549_Chip-Seq_REH_Human1.06378290
129TP63_19390658_ChIP-ChIP_HaCaT_Human1.05998845
130STAT3_23295773_ChIP-Seq_U87_Human1.05156773
131SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.03717355
132ESRRB_18555785_Chip-Seq_ESCs_Mouse1.02802492
133E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.02308370
134SOX9_26525672_Chip-Seq_HEART_Mouse1.01411070
135SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.01232125
136FOXM1_26456572_ChIP-Seq_MCF-7_Human0.99988014
137TP53_16413492_ChIP-PET_HCT116_Human0.99578615
138TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.97065589
139SOX2_21211035_ChIP-Seq_LN229_Gbm0.96214742
140EGR1_23403033_ChIP-Seq_LIVER_Mouse0.95612660

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001188_hyperpigmentation4.36290883
2MP0000569_abnormal_digit_pigmentation4.21358634
3MP0003136_yellow_coat_color3.51877960
4MP0002837_dystrophic_cardiac_calcinosis3.39833558
5MP0006292_abnormal_olfactory_placode3.25492852
6MP0003195_calcinosis3.14077017
7MP0005409_darkened_coat_color3.03750955
8MP0005646_abnormal_pituitary_gland2.97299529
9MP0008057_abnormal_DNA_replication2.78477837
10MP0002876_abnormal_thyroid_physiology2.72876854
11MP0000015_abnormal_ear_pigmentation2.71250906
12MP0009697_abnormal_copulation2.70589803
13MP0003787_abnormal_imprinting2.60713645
14MP0003646_muscle_fatigue2.56304454
15MP0000566_synostosis2.45769958
16MP0003880_abnormal_central_pattern2.42326899
17MP0003122_maternal_imprinting2.32325078
18MP0001986_abnormal_taste_sensitivity2.27441906
19MP0000372_irregular_coat_pigmentation2.24902960
20MP0004147_increased_porphyrin_level2.17931273
21MP0009379_abnormal_foot_pigmentation2.13073649
22MP0005367_renal/urinary_system_phenotyp1.99260553
23MP0000516_abnormal_urinary_system1.99260553
24MP0002653_abnormal_ependyma_morphology1.99203909
25MP0005171_absent_coat_pigmentation1.93399468
26MP0006072_abnormal_retinal_apoptosis1.83450739
27MP0000427_abnormal_hair_cycle1.79113179
28MP0004782_abnormal_surfactant_physiolog1.79062597
29MP0003121_genomic_imprinting1.78278597
30MP0001501_abnormal_sleep_pattern1.78169036
31MP0006276_abnormal_autonomic_nervous1.67342506
32MP0002751_abnormal_autonomic_nervous1.65773141
33MP0004270_analgesia1.61860457
34MP0002938_white_spotting1.61528335
35MP0001984_abnormal_olfaction1.57321831
36MP0005075_abnormal_melanosome_morpholog1.55681351
37MP0002163_abnormal_gland_morphology1.54855176
38MP0002638_abnormal_pupillary_reflex1.52997548
39MP0008872_abnormal_physiological_respon1.49427790
40MP0005379_endocrine/exocrine_gland_phen1.48236839
41MP0003315_abnormal_perineum_morphology1.47245925
42MP0004043_abnormal_pH_regulation1.47115630
43MP0000678_abnormal_parathyroid_gland1.44945084
44MP0004381_abnormal_hair_follicle1.44816257
45MP0002160_abnormal_reproductive_system1.43336460
46MP0000681_abnormal_thyroid_gland1.41867264
47MP0001968_abnormal_touch/_nociception1.41565765
48MP0002249_abnormal_larynx_morphology1.40855838
49MP0003941_abnormal_skin_development1.40238263
50MP0002734_abnormal_mechanical_nocicepti1.39461005
51MP0005551_abnormal_eye_electrophysiolog1.38464722
52MP0001764_abnormal_homeostasis1.38235441
53MP0002736_abnormal_nociception_after1.36758084
54MP0008058_abnormal_DNA_repair1.34058726
55MP0005645_abnormal_hypothalamus_physiol1.33231038
56MP0005085_abnormal_gallbladder_physiolo1.31493565
57MP0008789_abnormal_olfactory_epithelium1.30794789
58MP0000631_abnormal_neuroendocrine_gland1.30672266
59MP0001905_abnormal_dopamine_level1.30671197
60MP0004142_abnormal_muscle_tone1.30190841
61MP0002095_abnormal_skin_pigmentation1.29657338
62MP0001177_atelectasis1.29021532
63MP0003942_abnormal_urinary_system1.27868648
64MP0003123_paternal_imprinting1.27207809
65MP0000049_abnormal_middle_ear1.27105548
66MP0004145_abnormal_muscle_electrophysio1.27075594
67MP0000383_abnormal_hair_follicle1.26912771
68MP0001529_abnormal_vocalization1.26580185
69MP0001919_abnormal_reproductive_system1.26437949
70MP0002735_abnormal_chemical_nociception1.25560696
71MP0003045_fibrosis1.25396403
72MP0003950_abnormal_plasma_membrane1.25393862
73MP0002272_abnormal_nervous_system1.24860914
74MP0001485_abnormal_pinna_reflex1.24582702
75MP0002132_abnormal_respiratory_system1.20987755
76MP0002177_abnormal_outer_ear1.19589820
77MP0002138_abnormal_hepatobiliary_system1.18067400
78MP0002067_abnormal_sensory_capabilities1.17981275
79MP0002928_abnormal_bile_duct1.16284140
80MP0001963_abnormal_hearing_physiology1.15191208
81MP0005408_hypopigmentation1.14735478
82MP0008260_abnormal_autophagy1.14720276
83MP0002009_preneoplasia1.13896700
84MP0000026_abnormal_inner_ear1.13865576
85MP0005389_reproductive_system_phenotype1.11914856
86MP0005174_abnormal_tail_pigmentation1.10579837
87MP0002234_abnormal_pharynx_morphology1.09675238
88MP0002184_abnormal_innervation1.09460633
89MP0008877_abnormal_DNA_methylation1.09261341
90MP0009745_abnormal_behavioral_response1.07600834
91MP0005084_abnormal_gallbladder_morpholo1.07481739
92MP0009250_abnormal_appendicular_skeleto1.07186638
93MP0005670_abnormal_white_adipose1.05063485
94MP0002254_reproductive_system_inflammat1.04989806
95MP0006054_spinal_hemorrhage1.03833120
96MP0003252_abnormal_bile_duct1.01631040
97MP0002572_abnormal_emotion/affect_behav1.00939183
98MP0005386_behavior/neurological_phenoty1.00681558
99MP0004924_abnormal_behavior1.00681558
100MP0005499_abnormal_olfactory_system0.99878952
101MP0005394_taste/olfaction_phenotype0.99878952
102MP0003385_abnormal_body_wall0.99604890
103MP0004215_abnormal_myocardial_fiber0.99234518
104MP0003943_abnormal_hepatobiliary_system0.98995789
105MP0002277_abnormal_respiratory_mucosa0.95750592
106MP0001324_abnormal_eye_pigmentation0.95121823
107MP0000778_abnormal_nervous_system0.94903039
108MP0004133_heterotaxia0.94161060
109MP0009046_muscle_twitch0.93667202
110MP0005395_other_phenotype0.93048201
111MP0010094_abnormal_chromosome_stability0.92844015
112MP0002557_abnormal_social/conspecific_i0.92681201
113MP0005266_abnormal_metabolism0.91340526
114MP0005195_abnormal_posterior_eye0.90936330
115MP0008875_abnormal_xenobiotic_pharmacok0.90922229
116MP0005647_abnormal_sex_gland0.90367996
117MP0000538_abnormal_urinary_bladder0.89972785
118MP0003937_abnormal_limbs/digits/tail_de0.89551174
119MP0003890_abnormal_embryonic-extraembry0.89122757
120MP0002168_other_aberrant_phenotype0.88910034
121MP0008995_early_reproductive_senescence0.88862900
122MP0001486_abnormal_startle_reflex0.88622020
123MP0005253_abnormal_eye_physiology0.87183891
124MP0001119_abnormal_female_reproductive0.86572141
125MP0008961_abnormal_basal_metabolism0.86055439
126MP0000371_diluted_coat_color0.85738902
127MP0003938_abnormal_ear_development0.85057042
128MP0000647_abnormal_sebaceous_gland0.80801002
129MP0001929_abnormal_gametogenesis0.80020282
130MP0003698_abnormal_male_reproductive0.79528876
131MP0003718_maternal_effect0.78891628
132MP0002229_neurodegeneration0.77654199
133MP0002102_abnormal_ear_morphology0.77650608
134MP0002752_abnormal_somatic_nervous0.77328840
135MP0003119_abnormal_digestive_system0.76765316
136MP0001970_abnormal_pain_threshold0.76278958
137MP0002090_abnormal_vision0.76054384
138MP0002233_abnormal_nose_morphology0.75979501
139MP0002109_abnormal_limb_morphology0.74645850
140MP0002733_abnormal_thermal_nociception0.74018461
141MP0000230_abnormal_systemic_arterial0.73112371
142MP0002064_seizures0.72710267
143MP0010386_abnormal_urinary_bladder0.72143859
144MP0003724_increased_susceptibility_to0.71776857
145MP0003786_premature_aging0.71347205
146MP0004134_abnormal_chest_morphology0.71240747
147MP0001186_pigmentation_phenotype0.70831263
148MP0001664_abnormal_digestion0.70410392
149MP0003635_abnormal_synaptic_transmissio0.67270720

Predicted human phenotypes

RankGene SetZ-score
1True hermaphroditism (HP:0010459)3.94977190
2Hypothermia (HP:0002045)3.91799645
3Pancreatic fibrosis (HP:0100732)3.70875871
4Medial flaring of the eyebrow (HP:0010747)3.40750908
5Congenital stationary night blindness (HP:0007642)3.37171660
6Nephrogenic diabetes insipidus (HP:0009806)3.31207201
7Congenital primary aphakia (HP:0007707)3.24090221
8Gait imbalance (HP:0002141)3.22681392
9Abnormality of incisor morphology (HP:0011063)3.17838335
10Aplasia/Hypoplasia of the tibia (HP:0005772)3.13598210
11Short tibia (HP:0005736)3.10725297
12Abnormal hair whorl (HP:0010721)3.10286337
13Abnormality of the renal cortex (HP:0011035)3.05724445
14* Type I transferrin isoform profile (HP:0003642)2.91860324
15Febrile seizures (HP:0002373)2.89829787
16Hyperventilation (HP:0002883)2.87111982
17Nephroblastoma (Wilms tumor) (HP:0002667)2.84887730
18Poor coordination (HP:0002370)2.84497963
19Embryonal renal neoplasm (HP:0011794)2.81193047
20Reduced antithrombin III activity (HP:0001976)2.80091346
21Genital tract atresia (HP:0001827)2.76333424
22Severe visual impairment (HP:0001141)2.72208178
23Cystic liver disease (HP:0006706)2.70664182
24Chronic hepatic failure (HP:0100626)2.70376783
25Vaginal atresia (HP:0000148)2.65212989
26Pancreatic cysts (HP:0001737)2.60539282
27Thyroid-stimulating hormone excess (HP:0002925)2.55561482
28Inability to walk (HP:0002540)2.54852125
29Hepatoblastoma (HP:0002884)2.53130748
30Focal motor seizures (HP:0011153)2.51700088
31Progressive inability to walk (HP:0002505)2.51644271
32Genetic anticipation (HP:0003743)2.50205839
33Absent eyebrow (HP:0002223)2.47668295
34Type II lissencephaly (HP:0007260)2.47454682
35Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.46056281
36Abnormality of alanine metabolism (HP:0010916)2.46056281
37Hyperalaninemia (HP:0003348)2.46056281
38Abnormality of the labia minora (HP:0012880)2.44736389
39Progressive cerebellar ataxia (HP:0002073)2.44354065
40Postaxial foot polydactyly (HP:0001830)2.41801734
41Tubular atrophy (HP:0000092)2.41684796
42Cerebellar dysplasia (HP:0007033)2.39966785
43Abolished electroretinogram (ERG) (HP:0000550)2.39297784
44Large for gestational age (HP:0001520)2.38336418
45Enlarged kidneys (HP:0000105)2.38193435
46Acute necrotizing encephalopathy (HP:0006965)2.37747368
47Preaxial hand polydactyly (HP:0001177)2.37392370
48Decreased central vision (HP:0007663)2.37290270
49Attenuation of retinal blood vessels (HP:0007843)2.36138350
50Aplasia/Hypoplasia of the uvula (HP:0010293)2.34367492
51Tubulointerstitial nephritis (HP:0001970)2.27956922
52Optic nerve hypoplasia (HP:0000609)2.26302214
53Dyschromatopsia (HP:0007641)2.24899496
54Abnormality of the pons (HP:0007361)2.24822650
55Hypoplasia of the pons (HP:0012110)2.23077822
56Type 2 muscle fiber atrophy (HP:0003554)2.22829760
57Nephronophthisis (HP:0000090)2.22716782
58Chromosomal breakage induced by crosslinking agents (HP:0003221)2.22216854
59Sclerocornea (HP:0000647)2.21822186
60Metaphyseal dysplasia (HP:0100255)2.21769444
61Aplasia/Hypoplasia of the lens (HP:0008063)2.20697658
62Aplasia/Hypoplasia of the tongue (HP:0010295)2.19872847
63Polydipsia (HP:0001959)2.19811402
64Abnormal drinking behavior (HP:0030082)2.19811402
65Small hand (HP:0200055)2.17464911
66Colon cancer (HP:0003003)2.17373692
67Chromsome breakage (HP:0040012)2.16775343
68Protruding tongue (HP:0010808)2.16151725
69Congenital hepatic fibrosis (HP:0002612)2.15439348
70Prolonged partial thromboplastin time (HP:0003645)2.15393266
71Furrowed tongue (HP:0000221)2.14635580
72Occipital encephalocele (HP:0002085)2.13949280
73Abnormal lung lobation (HP:0002101)2.12554461
74Optic disc pallor (HP:0000543)2.12010211
75Aplasia/Hypoplasia of the fovea (HP:0008060)2.11725882
76Hypoplasia of the fovea (HP:0007750)2.11725882
77Broad-based gait (HP:0002136)2.09919070
783-Methylglutaconic aciduria (HP:0003535)2.09587738
79Diastasis recti (HP:0001540)2.08814209
80Lissencephaly (HP:0001339)2.08332746
81Pendular nystagmus (HP:0012043)2.07115265
82Congenital, generalized hypertrichosis (HP:0004540)2.05716998
83Anencephaly (HP:0002323)2.05601124
84Nonprogressive disorder (HP:0003680)2.05495712
85Male pseudohermaphroditism (HP:0000037)2.05394816
86Stomach cancer (HP:0012126)2.04737228
87Mitochondrial inheritance (HP:0001427)2.04439562
88Microvesicular hepatic steatosis (HP:0001414)2.04284980
89Bony spicule pigmentary retinopathy (HP:0007737)2.03638713
90Renal cortical cysts (HP:0000803)2.03619813
91Progressive macrocephaly (HP:0004481)2.03539538
92Conjugated hyperbilirubinemia (HP:0002908)2.03152640
93Congenital sensorineural hearing impairment (HP:0008527)2.02245015
94Adrenal hypoplasia (HP:0000835)2.01818627
95Abnormal mitochondria in muscle tissue (HP:0008316)2.00076648
96Methylmalonic acidemia (HP:0002912)1.99995418
97Bile duct proliferation (HP:0001408)1.99266785
98Abnormal biliary tract physiology (HP:0012439)1.99266785
99Fair hair (HP:0002286)1.98520201
100Absent speech (HP:0001344)1.96282542
101Absent rod-and cone-mediated responses on ERG (HP:0007688)1.95977861
102Increased CSF lactate (HP:0002490)1.95819089
103Median cleft lip (HP:0000161)1.94874128
104Methylmalonic aciduria (HP:0012120)1.94308528
105Abnormality of the renal medulla (HP:0100957)1.93927307
106Dialeptic seizures (HP:0011146)1.92283622
107Blue irides (HP:0000635)1.92102625
108Hepatocellular necrosis (HP:0001404)1.90637604
109Renal Fanconi syndrome (HP:0001994)1.90620074
110Abnormality of chromosome stability (HP:0003220)1.89895643
111Intestinal atresia (HP:0011100)1.88890454
112Postaxial hand polydactyly (HP:0001162)1.88860032
113Abnormality of the nasal septum (HP:0000419)1.88730868
114Keratoconus (HP:0000563)1.87891667
115Increased corneal curvature (HP:0100692)1.87891667
116Abnormal rod and cone electroretinograms (HP:0008323)1.87230196
117Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.86570558
118Renal hypoplasia (HP:0000089)1.85164946
119Gaze-evoked nystagmus (HP:0000640)1.83823407
120Ketoacidosis (HP:0001993)1.83693048
121Decreased electroretinogram (ERG) amplitude (HP:0000654)1.83451163
122Widely spaced teeth (HP:0000687)1.82918958
123Albinism (HP:0001022)1.82769338
124Abnormality of midbrain morphology (HP:0002418)1.82745049
125Molar tooth sign on MRI (HP:0002419)1.82745049
126Constricted visual fields (HP:0001133)1.82151875
127Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.81939566
128Abnormality of macular pigmentation (HP:0008002)1.81468659
129Broad foot (HP:0001769)1.81005344
130Abnormality of the renal collecting system (HP:0004742)1.80922090
131Sloping forehead (HP:0000340)1.80341128
132Epileptic encephalopathy (HP:0200134)1.80177546
133Abnormality of the lacrimal duct (HP:0011481)1.80040276
134Central scotoma (HP:0000603)1.80029776
135Alveolar cell carcinoma (HP:0006519)1.79954387
136Astigmatism (HP:0000483)1.79728327
137Clumsiness (HP:0002312)1.79175212
138Dandy-Walker malformation (HP:0001305)1.78917663
139Duplicated collecting system (HP:0000081)1.78746570
140Patchy hypopigmentation of hair (HP:0011365)1.77739063
141Supernumerary spleens (HP:0009799)1.77491106
142Hemiparesis (HP:0001269)1.76999427
143Popliteal pterygium (HP:0009756)1.75783214
144Thyroiditis (HP:0100646)1.75317528
145Chorioretinal atrophy (HP:0000533)1.74786678
146Abnormality of the ileum (HP:0001549)1.74639411
147Amelogenesis imperfecta (HP:0000705)1.73704140
148Hypoplastic left heart (HP:0004383)1.73072104
149Acute encephalopathy (HP:0006846)1.72998533
150Respiratory difficulties (HP:0002880)1.72988098
151Abnormal ciliary motility (HP:0012262)1.72834531
152Abnormality of the nasolacrimal system (HP:0000614)1.71794250
153Meckel diverticulum (HP:0002245)1.71070009
154Generalized hypopigmentation of hair (HP:0011358)1.70841953
155Clubbing of toes (HP:0100760)1.70542321
156Embryonal neoplasm (HP:0002898)1.69913524
157Atonic seizures (HP:0010819)1.69851150
158Aganglionic megacolon (HP:0002251)1.69246056
159Renal tubular dysfunction (HP:0000124)1.68685111
160Submucous cleft hard palate (HP:0000176)1.68585201
161* Abnormal protein N-linked glycosylation (HP:0012347)1.68057432
162* Abnormal glycosylation (HP:0012345)1.68057432

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK6.14725825
2MKNK23.21390800
3AKT32.92256254
4TNIK2.71809161
5MAP4K22.65744258
6PRPF4B2.60511583
7MKNK12.48341775
8WNK32.47616065
9MUSK2.40578669
10EIF2AK32.37277478
11MAP2K72.29624709
12LATS12.13712188
13MAPK132.11865300
14MAP3K121.98398370
15STK161.95353570
16SGK21.88794386
17SRPK11.85527460
18NEK61.79953088
19YES11.71811229
20TRIM281.68142478
21EIF2AK21.65995655
22ZAK1.58856761
23SIK31.56801320
24MAP3K41.48630006
25TAOK31.48529505
26BRSK21.47806483
27BMPR1B1.42773091
28SGK2231.29677340
29SGK4941.29677340
30PLK21.27907170
31BMPR21.25312966
32NEK91.23975657
33FGFR21.23271816
34NLK1.21720656
35FRK1.19191109
36STK31.18405491
37INSRR1.17262195
38ADRBK21.16145068
39TXK1.13636213
40MAP3K141.13591599
41PLK31.13371740
42STK391.11765429
43GRK71.11029805
44BCR1.10752644
45ERBB31.09922612
46VRK11.06721786
47CCNB11.06437603
48PAK31.06201465
49IRAK41.05706796
50CDK31.04583922
51PIK3CG0.98504947
52TGFBR10.97638638
53NUAK10.97127295
54PNCK0.96482143
55SGK30.95881004
56TAOK20.94480326
57TSSK60.94343794
58BRAF0.92503012
59WNK40.90577092
60CDK80.86379884
61TRPM70.85544038
62PINK10.85118312
63EPHA40.83030921
64GRK10.82121274
65MYLK0.81805176
66IRAK20.81435730
67TEC0.81333453
68OXSR10.80972571
69IRAK30.72818138
70CSNK1G10.69921768
71ERBB40.67485388
72WEE10.67137271
73PRKCE0.64889387
74CSNK1G30.63486141
75PASK0.61564456
76STK38L0.61409866
77MAPKAPK50.60210375
78FER0.59584958
79STK240.58761729
80RPS6KB10.57475065
81CDK190.57462367
82MARK10.57402537
83MST40.56959895
84IRAK10.56900745
85MELK0.56795812
86TNK20.56718316
87RPS6KA20.56676306
88CLK10.55921694
89PRKAA20.55897415
90PIM20.55298491
91TAF10.55240795
92NTRK30.54419160
93PLK40.51063802
94PTK2B0.50733468
95DAPK20.50501994
96PLK10.50285954
97EPHA30.50201706
98NEK20.49597387
99ADRBK10.49576260
100STK380.48695732
101PIK3CA0.48338296
102CAMK1G0.47585646
103PDK20.46592233
104CSNK1A1L0.45963295
105BRSK10.45531094
106BRD40.44857706
107CAMKK20.44331107
108DYRK20.43427231
109ATM0.42521750
110EIF2AK10.42425511
111CAMK2B0.42305330
112RPS6KL10.41729709
113RPS6KC10.41729709
114ATR0.41652828
115CHEK20.40626150
116PRKCG0.40208888
117UHMK10.39886830
118PKN10.38220435
119RPS6KA60.37678270
120CHUK0.37377626
121TIE10.36890768
122STK110.36273145
123CSNK1A10.35852344
124NTRK20.35230182
125DAPK10.35151598
126CSNK1D0.34602941
127GRK50.34578812
128CAMK2A0.33761985
129PRKACA0.33742603
130CSNK2A10.33439249
131RPS6KA50.32707076
132BUB10.32488375
133CAMK10.32136085
134CSNK1G20.31965423
135PRKG10.31804449
136ERBB20.31793007
137PRKAA10.31222925
138PRKACB0.29877329
139PBK0.29597152
140ITK0.28036114
141TLK10.27804804
142IKBKB0.27745970
143ACVR1B0.27320837
144OBSCN0.26617672

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030603.91520181
2Phototransduction_Homo sapiens_hsa047443.33368609
3Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.73492320
4Homologous recombination_Homo sapiens_hsa034402.71231933
5Butanoate metabolism_Homo sapiens_hsa006502.62982190
6Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.22908715
7RNA polymerase_Homo sapiens_hsa030202.20573945
8Tryptophan metabolism_Homo sapiens_hsa003802.14444228
9Nicotine addiction_Homo sapiens_hsa050332.09528948
10Selenocompound metabolism_Homo sapiens_hsa004502.09126066
11Basal transcription factors_Homo sapiens_hsa030222.03079989
12Nitrogen metabolism_Homo sapiens_hsa009102.02587704
13Fatty acid elongation_Homo sapiens_hsa000621.92746266
14Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.91363443
15Non-homologous end-joining_Homo sapiens_hsa034501.90380110
16Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.90051202
17Oxidative phosphorylation_Homo sapiens_hsa001901.89244299
18Propanoate metabolism_Homo sapiens_hsa006401.81359821
19Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.80277282
20Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.78942101
21Proteasome_Homo sapiens_hsa030501.77668858
22Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.73124390
23Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.72760805
24Fanconi anemia pathway_Homo sapiens_hsa034601.72622545
25Steroid hormone biosynthesis_Homo sapiens_hsa001401.67621656
26Steroid biosynthesis_Homo sapiens_hsa001001.67042995
27ABC transporters_Homo sapiens_hsa020101.64961635
28Mismatch repair_Homo sapiens_hsa034301.64066850
29Sulfur metabolism_Homo sapiens_hsa009201.62360707
30Caffeine metabolism_Homo sapiens_hsa002321.61125455
31SNARE interactions in vesicular transport_Homo sapiens_hsa041301.56899223
32Nucleotide excision repair_Homo sapiens_hsa034201.54137018
33Maturity onset diabetes of the young_Homo sapiens_hsa049501.53179094
34Collecting duct acid secretion_Homo sapiens_hsa049661.45099853
35Arachidonic acid metabolism_Homo sapiens_hsa005901.41001564
36DNA replication_Homo sapiens_hsa030301.40648138
37Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.39225708
38Serotonergic synapse_Homo sapiens_hsa047261.32286929
39Purine metabolism_Homo sapiens_hsa002301.29843071
40Regulation of autophagy_Homo sapiens_hsa041401.29184638
41Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.25871963
42Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.25165911
43Pyrimidine metabolism_Homo sapiens_hsa002401.25090244
44Taste transduction_Homo sapiens_hsa047421.24402443
45Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.23885054
46Vibrio cholerae infection_Homo sapiens_hsa051101.22602529
47RNA degradation_Homo sapiens_hsa030181.16711400
48Base excision repair_Homo sapiens_hsa034101.14252354
49Parkinsons disease_Homo sapiens_hsa050121.13548844
50Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.12494081
51Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.12046523
52Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.08010232
53Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.06163203
54Synaptic vesicle cycle_Homo sapiens_hsa047211.02463062
55Olfactory transduction_Homo sapiens_hsa047401.02364731
56Retinol metabolism_Homo sapiens_hsa008301.01317426
57Huntingtons disease_Homo sapiens_hsa050161.00303600
58Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.00300651
59Type I diabetes mellitus_Homo sapiens_hsa049401.00141072
60beta-Alanine metabolism_Homo sapiens_hsa004100.98669680
61Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.96594997
62Rheumatoid arthritis_Homo sapiens_hsa053230.95855272
63Ether lipid metabolism_Homo sapiens_hsa005650.93569662
64Glycerolipid metabolism_Homo sapiens_hsa005610.92452886
65Sphingolipid metabolism_Homo sapiens_hsa006000.92441793
66Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.92210231
67Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.89276737
68Lysine degradation_Homo sapiens_hsa003100.88784123
69Drug metabolism - other enzymes_Homo sapiens_hsa009830.88085242
70Alzheimers disease_Homo sapiens_hsa050100.87999375
71Morphine addiction_Homo sapiens_hsa050320.87940046
72Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.85845821
73Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.85374697
74Allograft rejection_Homo sapiens_hsa053300.84733180
75Autoimmune thyroid disease_Homo sapiens_hsa053200.84276335
76Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.83816147
77GABAergic synapse_Homo sapiens_hsa047270.81521674
78Peroxisome_Homo sapiens_hsa041460.75623033
79Chemical carcinogenesis_Homo sapiens_hsa052040.75464482
80Dorso-ventral axis formation_Homo sapiens_hsa043200.72735937
81Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.71766468
82Phagosome_Homo sapiens_hsa041450.71669061
83* Metabolic pathways_Homo sapiens_hsa011000.70909531
84Glutamatergic synapse_Homo sapiens_hsa047240.69542378
85Asthma_Homo sapiens_hsa053100.69200208
86Linoleic acid metabolism_Homo sapiens_hsa005910.64358059
87Fatty acid degradation_Homo sapiens_hsa000710.63170798
88Tyrosine metabolism_Homo sapiens_hsa003500.62162932
89Circadian entrainment_Homo sapiens_hsa047130.61777434
90Circadian rhythm_Homo sapiens_hsa047100.60745786
91Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.60243661
92Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.56753570
93Salivary secretion_Homo sapiens_hsa049700.56404691
94Histidine metabolism_Homo sapiens_hsa003400.56309839
95TGF-beta signaling pathway_Homo sapiens_hsa043500.55955722
96One carbon pool by folate_Homo sapiens_hsa006700.54512677
97Pentose and glucuronate interconversions_Homo sapiens_hsa000400.54087033
98Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.53769462
99Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.53500468
100Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.53454623
101Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.51504522
102Graft-versus-host disease_Homo sapiens_hsa053320.50121303
103Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.47995544
104Cell cycle_Homo sapiens_hsa041100.47737129
105Amphetamine addiction_Homo sapiens_hsa050310.45724418
106Spliceosome_Homo sapiens_hsa030400.45610532
107Cysteine and methionine metabolism_Homo sapiens_hsa002700.45274234
108Fat digestion and absorption_Homo sapiens_hsa049750.45184887
109* N-Glycan biosynthesis_Homo sapiens_hsa005100.44796494
110Fatty acid metabolism_Homo sapiens_hsa012120.44505697
111Phenylalanine metabolism_Homo sapiens_hsa003600.44391189
112Insulin secretion_Homo sapiens_hsa049110.44156201
113alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.43553331
114Primary bile acid biosynthesis_Homo sapiens_hsa001200.43479181
115Dopaminergic synapse_Homo sapiens_hsa047280.43141203
116Long-term depression_Homo sapiens_hsa047300.42374921
117Vitamin digestion and absorption_Homo sapiens_hsa049770.42072817
118Thyroid cancer_Homo sapiens_hsa052160.38565541
119Transcriptional misregulation in cancer_Homo sapiens_hsa052020.38255383
120Vascular smooth muscle contraction_Homo sapiens_hsa042700.35101177
121Cardiac muscle contraction_Homo sapiens_hsa042600.34073276
122Ovarian steroidogenesis_Homo sapiens_hsa049130.33683882
123Mineral absorption_Homo sapiens_hsa049780.32892454
124Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.32543164
125RNA transport_Homo sapiens_hsa030130.31421660
126p53 signaling pathway_Homo sapiens_hsa041150.30357748
127Intestinal immune network for IgA production_Homo sapiens_hsa046720.29417766
128NF-kappa B signaling pathway_Homo sapiens_hsa040640.28956141
129Calcium signaling pathway_Homo sapiens_hsa040200.27949215
130Fatty acid biosynthesis_Homo sapiens_hsa000610.24380039
131Hedgehog signaling pathway_Homo sapiens_hsa043400.23029042

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