ALG1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The enzyme encoded by this gene catalyzes the first mannosylation step in the biosynthesis of lipid-linked oligosaccharides. This gene is mutated in congenital disorder of glycosylation type Ik. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1COPI coating of Golgi vesicle (GO:0048205)5.12702429
2Golgi transport vesicle coating (GO:0048200)5.12702429
3L-phenylalanine metabolic process (GO:0006558)4.42340726
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.42340726
5L-phenylalanine catabolic process (GO:0006559)4.26547412
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.26547412
7maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.14417466
8proline biosynthetic process (GO:0006561)4.10883174
9proteasome assembly (GO:0043248)4.06376342
10regulation of mitochondrial translation (GO:0070129)4.06160113
11protein retention in ER lumen (GO:0006621)3.87370099
12pseudouridine synthesis (GO:0001522)3.86402796
13sulfur amino acid catabolic process (GO:0000098)3.84681350
14fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.79985067
15valine metabolic process (GO:0006573)3.69256060
16cysteine metabolic process (GO:0006534)3.67167087
17DNA strand elongation involved in DNA replication (GO:0006271)3.59348346
18aromatic amino acid family catabolic process (GO:0009074)3.54613884
19negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.53129893
20retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.51823039
21DNA strand elongation (GO:0022616)3.47906415
22mitochondrial calcium ion transport (GO:0006851)3.45936058
23pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.41573784
24activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.40280432
25alpha-linolenic acid metabolic process (GO:0036109)3.37771809
26antigen processing and presentation via MHC class Ib (GO:0002475)3.37015786
27nucleobase biosynthetic process (GO:0046112)3.34920666
28negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.34353064
29negative regulation of ligase activity (GO:0051352)3.34353064
30protein carboxylation (GO:0018214)3.30065962
31peptidyl-glutamic acid carboxylation (GO:0017187)3.30065962
32* dolichol-linked oligosaccharide biosynthetic process (GO:0006488)3.29573716
33positive regulation of nuclease activity (GO:0032075)3.28636478
34regulation of translational termination (GO:0006449)3.27695526
35deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.25800256
36telomere maintenance via semi-conservative replication (GO:0032201)3.21263022
37regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.21007686
38response to misfolded protein (GO:0051788)3.20561204
39base-excision repair, AP site formation (GO:0006285)3.20158697
40regulation of cellular amino acid metabolic process (GO:0006521)3.19272319
41cellular modified amino acid catabolic process (GO:0042219)3.19249178
42drug transport (GO:0015893)3.19022607
43rRNA modification (GO:0000154)3.17683818
444-hydroxyproline metabolic process (GO:0019471)3.16251610
45positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.15487958
46protein maturation by protein folding (GO:0022417)3.15449252
47maturation of 5.8S rRNA (GO:0000460)3.14355908
48tricarboxylic acid metabolic process (GO:0072350)3.13142283
49peptidyl-arginine omega-N-methylation (GO:0035247)3.11274239
50mannose metabolic process (GO:0006013)3.10910643
51triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.10333015
52termination of RNA polymerase III transcription (GO:0006386)3.09734450
53transcription elongation from RNA polymerase III promoter (GO:0006385)3.09734450
54drug transmembrane transport (GO:0006855)3.06959156
55anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.06045174
56glyoxylate metabolic process (GO:0046487)3.05321398
57regulation of cholesterol homeostasis (GO:2000188)3.03414228
58regulation of translational fidelity (GO:0006450)3.03025176
59purine nucleobase biosynthetic process (GO:0009113)3.02213717
60ribosome assembly (GO:0042255)3.01920765
61endoplasmic reticulum unfolded protein response (GO:0030968)3.01109668
62regulation of nuclease activity (GO:0032069)2.98705987
63histone arginine methylation (GO:0034969)2.98218473
64nucleotide-sugar biosynthetic process (GO:0009226)2.97801161
65bile acid biosynthetic process (GO:0006699)2.94988829
66establishment of integrated proviral latency (GO:0075713)2.94619778
67proline metabolic process (GO:0006560)2.94513856
68folic acid metabolic process (GO:0046655)2.93211052
69DNA replication-dependent nucleosome assembly (GO:0006335)2.92573752
70DNA replication-dependent nucleosome organization (GO:0034723)2.92573752
71negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.92357606
72negative regulation of cAMP-mediated signaling (GO:0043951)2.91476546
73endosome to pigment granule transport (GO:0043485)2.91430043
74endosome to melanosome transport (GO:0035646)2.91430043
75regulation of cholesterol biosynthetic process (GO:0045540)2.90621438
76cellular response to topologically incorrect protein (GO:0035967)2.89962670
77chaperone mediated protein folding requiring cofactor (GO:0051085)2.89523747
78cellular response to unfolded protein (GO:0034620)2.89264841
79antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.88808521
80antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.88808521
81DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.87702004
82fatty acid beta-oxidation (GO:0006635)2.86952303
83indole-containing compound catabolic process (GO:0042436)2.86232329
84indolalkylamine catabolic process (GO:0046218)2.86232329
85tryptophan catabolic process (GO:0006569)2.86232329
86mitochondrial RNA metabolic process (GO:0000959)2.86082655
87IMP biosynthetic process (GO:0006188)2.85925085
88coenzyme catabolic process (GO:0009109)2.85683596
89intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.85562681
90signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.85562681
91toxin transport (GO:1901998)2.85053277
92pantothenate metabolic process (GO:0015939)2.84635778
93signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.84356540
94signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.84356540
95signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.84356540
96ER-nucleus signaling pathway (GO:0006984)2.84042240
97misfolded or incompletely synthesized protein catabolic process (GO:0006515)2.83130782
98purine ribonucleotide transport (GO:0015868)2.81791207
99antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.81341661
100signal transduction involved in DNA integrity checkpoint (GO:0072401)2.80687751
101signal transduction involved in DNA damage checkpoint (GO:0072422)2.80687751
102ER overload response (GO:0006983)2.80506176
103signal peptide processing (GO:0006465)2.80129017
104lysine catabolic process (GO:0006554)2.79815942
105lysine metabolic process (GO:0006553)2.79815942
106tryptophan metabolic process (GO:0006568)2.77835042
1072-oxoglutarate metabolic process (GO:0006103)2.77733757
108pentose-phosphate shunt (GO:0006098)2.77290053
109positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.76668773
110ribosome biogenesis (GO:0042254)2.76298695
111fatty acid catabolic process (GO:0009062)2.76266115
112establishment of viral latency (GO:0019043)2.76007007
113oxidative phosphorylation (GO:0006119)2.75361100
114respiratory chain complex IV assembly (GO:0008535)2.75280689
115serine family amino acid biosynthetic process (GO:0009070)2.74728263
116tRNA aminoacylation (GO:0043039)2.74599782
117amino acid activation (GO:0043038)2.74599782
118reverse cholesterol transport (GO:0043691)2.74571582
119tRNA aminoacylation for protein translation (GO:0006418)2.74050896
120L-alpha-amino acid transmembrane transport (GO:1902475)2.73620469
121pyrimidine nucleotide catabolic process (GO:0006244)2.73421951
122negative regulation of DNA-templated transcription, elongation (GO:0032785)2.72519160
123deoxyribonucleotide catabolic process (GO:0009264)2.71324338
124RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.71252431
125tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.71252431
126aromatic amino acid family metabolic process (GO:0009072)2.71248458
127signal transduction involved in cell cycle checkpoint (GO:0072395)2.71205533
128fatty acid oxidation (GO:0019395)2.70544488
129lipid oxidation (GO:0034440)2.70416662
130ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)2.69219698
131pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.68917649
132nuclear envelope reassembly (GO:0031468)2.68051346
133mitotic nuclear envelope reassembly (GO:0007084)2.68051346
134positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.67736493
135GDP-mannose metabolic process (GO:0019673)2.67703641
136nucleoside salvage (GO:0043174)2.66551609
137pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.66133619
138regulation of cholesterol metabolic process (GO:0090181)2.65560366
139deoxyribose phosphate catabolic process (GO:0046386)2.65076118
140peptide catabolic process (GO:0043171)2.64864274
141DNA replication initiation (GO:0006270)2.63915884
142fructose metabolic process (GO:0006000)2.62286868
143mitochondrial DNA replication (GO:0006264)2.61197618
144cytochrome complex assembly (GO:0017004)2.61078522
145pteridine-containing compound biosynthetic process (GO:0042559)2.60989842
146monocarboxylic acid catabolic process (GO:0072329)2.60215162
147nucleobase-containing small molecule interconversion (GO:0015949)2.59652009
148positive regulation of ligase activity (GO:0051351)2.59553464
149cellular metabolic compound salvage (GO:0043094)2.58830871
150high-density lipoprotein particle remodeling (GO:0034375)2.58747319
151telomere maintenance via recombination (GO:0000722)2.58356008
152antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.58047572
153homocysteine metabolic process (GO:0050667)2.57690105
154serine family amino acid metabolic process (GO:0009069)2.57366642
155UTP biosynthetic process (GO:0006228)2.57028329
156DNA unwinding involved in DNA replication (GO:0006268)2.55963120
157amino-acid betaine metabolic process (GO:0006577)2.55769117
158peptidyl-arginine methylation (GO:0018216)2.55745783
159peptidyl-arginine N-methylation (GO:0035246)2.55745783
160DNA replication checkpoint (GO:0000076)2.55322855
161L-serine metabolic process (GO:0006563)2.55033508
162mitochondrial DNA metabolic process (GO:0032042)2.54402100
163pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.53869637
164heparin metabolic process (GO:0030202)2.53201336
165heparin biosynthetic process (GO:0030210)2.53201336
166rRNA transcription (GO:0009303)2.53160822
167phospholipid efflux (GO:0033700)2.53149949
168pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.53112851
169tRNA methylation (GO:0030488)2.52991589
170regulation of ubiquitin-protein transferase activity (GO:0051438)2.52900127
171COPII vesicle coating (GO:0048208)2.51738433
172folic acid-containing compound biosynthetic process (GO:0009396)2.51650973
173bile acid metabolic process (GO:0008206)2.51483082
174guanosine-containing compound biosynthetic process (GO:1901070)2.50965273
175coenzyme A metabolic process (GO:0015936)2.50411595
176NADPH regeneration (GO:0006740)2.50221049
177pyrimidine nucleoside salvage (GO:0043097)2.50140362
178pyrimidine-containing compound salvage (GO:0008655)2.50140362
179rRNA methylation (GO:0031167)2.49738894
180purine-containing compound salvage (GO:0043101)2.49507868
181oxaloacetate metabolic process (GO:0006107)2.49172353
182cellular amino acid catabolic process (GO:0009063)2.48727099
183nucleotide salvage (GO:0043173)2.48254391
184L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.48101071
185negative regulation of cholesterol transport (GO:0032375)2.47303132
186negative regulation of sterol transport (GO:0032372)2.47303132
187aldehyde catabolic process (GO:0046185)2.46667864
188branched-chain amino acid metabolic process (GO:0009081)2.46420377
189low-density lipoprotein particle remodeling (GO:0034374)2.46369020
190organic acid catabolic process (GO:0016054)2.46319017

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.16926879
2E2F7_22180533_ChIP-Seq_HELA_Human4.68835455
3RXR_22158963_ChIP-Seq_LIVER_Mouse3.56295058
4PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.51809730
5PPARA_22158963_ChIP-Seq_LIVER_Mouse3.30340526
6* CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.79783266
7IRF8_22096565_ChIP-ChIP_GC-B_Human2.55798503
8* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.46829546
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.39700899
10LXR_22158963_ChIP-Seq_LIVER_Mouse2.33210235
11FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.30151455
12EST1_17652178_ChIP-ChIP_JURKAT_Human2.29951168
13TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.28976408
14EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.26339581
15CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.20928153
16THAP11_20581084_ChIP-Seq_MESCs_Mouse2.19980017
17NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.18154446
18TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.08623732
19MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.06282648
20RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.02479264
21MYC_19079543_ChIP-ChIP_MESCs_Mouse2.02130973
22PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.97694991
23* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.97011088
24FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.95195819
25EGR1_23403033_ChIP-Seq_LIVER_Mouse1.88364614
26CLOCK_20551151_ChIP-Seq_293T_Human1.84048306
27E2F4_17652178_ChIP-ChIP_JURKAT_Human1.83804734
28GATA1_22025678_ChIP-Seq_K562_Human1.82645600
29FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.82539085
30VDR_21846776_ChIP-Seq_THP-1_Human1.81227174
31MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.80480247
32GABP_17652178_ChIP-ChIP_JURKAT_Human1.77140254
33SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.77059002
34FOXM1_23109430_ChIP-Seq_U2OS_Human1.75853870
35YY1_21170310_ChIP-Seq_MESCs_Mouse1.74407437
36* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.73083937
37DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.70349721
38E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.67766140
39CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.66737076
40TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.63349851
41LXR_22292898_ChIP-Seq_THP-1_Human1.62068593
42* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.61484149
43TTF2_22483619_ChIP-Seq_HELA_Human1.60723748
44* TFEB_21752829_ChIP-Seq_HELA_Human1.58103936
45NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.57248140
46* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.55253282
47DCP1A_22483619_ChIP-Seq_HELA_Human1.54234502
48ETS1_20019798_ChIP-Seq_JURKAT_Human1.53605336
49RARG_19884340_ChIP-ChIP_MEFs_Mouse1.52458998
50MYB_21317192_ChIP-Seq_ERMYB_Mouse1.47951539
51E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.47740442
52ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.47342776
53* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.46526694
54KDM5A_27292631_Chip-Seq_BREAST_Human1.46098637
55HOXB4_20404135_ChIP-ChIP_EML_Mouse1.45877539
56* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.44316990
57STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.44209127
58SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.43053060
59NANOG_18555785_ChIP-Seq_MESCs_Mouse1.42357248
60MYC_18358816_ChIP-ChIP_MESCs_Mouse1.40262166
61* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.40200248
62POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.39696161
63SRF_21415370_ChIP-Seq_HL-1_Mouse1.37647401
64MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.36218629
65E2F1_21310950_ChIP-Seq_MCF-7_Human1.31654993
66ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.31209419
67E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.31045988
68MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.30152345
69IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.29317591
70* SPI1_23547873_ChIP-Seq_NB4_Human1.28513211
71SCL_19346495_ChIP-Seq_HPC-7_Human1.26938572
72CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.26506496
73NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.26046039
74GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.25423908
75THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.23986616
76* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.22909313
77ELF1_17652178_ChIP-ChIP_JURKAT_Human1.21527488
78STAT3_1855785_ChIP-Seq_MESCs_Mouse1.21084087
79ZNF263_19887448_ChIP-Seq_K562_Human1.20787533
80MYC_18555785_ChIP-Seq_MESCs_Mouse1.20563482
81VDR_24763502_ChIP-Seq_THP-1_Human1.20492399
82GABP_19822575_ChIP-Seq_HepG2_Human1.20161895
83GATA1_22383799_ChIP-Seq_G1ME_Mouse1.19484431
84ELF1_20517297_ChIP-Seq_JURKAT_Human1.18782058
85SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.18355515
86SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.17518947
87POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.17472091
88KLF4_18555785_ChIP-Seq_MESCs_Mouse1.16866481
89AR_21909140_ChIP-Seq_LNCAP_Human1.16838501
90BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.15968311
91VDR_23849224_ChIP-Seq_CD4+_Human1.15963878
92HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.15127832
93MYC_22102868_ChIP-Seq_BL_Human1.14014916
94BRD4_27068464_Chip-Seq_AML-cells_Mouse1.13794322
95RUNX1_22412390_ChIP-Seq_EML_Mouse1.13005757
96PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.12648114
97IRF8_21731497_ChIP-ChIP_J774_Mouse1.12368489
98FOXP1_21924763_ChIP-Seq_HESCs_Human1.12276506
99XRN2_22483619_ChIP-Seq_HELA_Human1.11347807
100HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.11283436
101* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.11164765
102* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.09636887
103FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.08949853
104PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.08017179
105CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.07775735
106CTCF_18555785_ChIP-Seq_MESCs_Mouse1.06931665
107LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.06830954
108CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.06133877
109KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.06118740
110ELK1_19687146_ChIP-ChIP_HELA_Human1.05814272
111TET1_21451524_ChIP-Seq_MESCs_Mouse1.05765313
112* ELK3_25401928_ChIP-Seq_HUVEC_Human1.05639194
113SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.05288542
114BCL6_27268052_Chip-Seq_Bcells_Human1.05058586
115PADI4_21655091_ChIP-ChIP_MCF-7_Human1.04731199
116KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.04320723
117NOTCH1_21737748_ChIP-Seq_TLL_Human1.03971481
118HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.03850179
119CREB1_15753290_ChIP-ChIP_HEK293T_Human1.03449336
120* CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.03069279
121FOXP3_21729870_ChIP-Seq_TREG_Human1.03045224
122GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.02685464
123CIITA_25753668_ChIP-Seq_RAJI_Human1.01608596
124FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.01349217
125RACK7_27058665_Chip-Seq_MCF-7_Human1.01260782
126MYB_26560356_Chip-Seq_TH2_Human1.01113061
127MAF_26560356_Chip-Seq_TH1_Human1.00900132
128SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.99553598
129* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.99340683
130CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.98952916
131UTX_26944678_Chip-Seq_JUKART_Human0.98898425
132P68_20966046_ChIP-Seq_HELA_Human0.97353476
133PU.1_20513432_ChIP-Seq_Bcells_Mouse0.96897440
134FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.96623638
135ESR1_15608294_ChIP-ChIP_MCF-7_Human0.96595218
136LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.95240148
137CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.94739103
138CTCF_21964334_ChIP-Seq_BJAB-B_Human0.94375337
139TBX5_21415370_ChIP-Seq_HL-1_Mouse0.93837145
140TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.93408451
141BCOR_27268052_Chip-Seq_Bcells_Human0.92919147
142MYC_18940864_ChIP-ChIP_HL60_Human0.90729830
143* RARB_24833708_ChIP-Seq_LIVER_Mouse0.88531948
144DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.87390822
145CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.87277315

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.40048078
2MP0009840_abnormal_foam_cell4.23421354
3MP0002139_abnormal_hepatobiliary_system3.84325673
4MP0005360_urolithiasis3.70529884
5MP0005058_abnormal_lysosome_morphology3.70376486
6MP0005365_abnormal_bile_salt3.50780647
7MP0003191_abnormal_cellular_cholesterol3.45053043
8MP0003111_abnormal_nucleus_morphology3.42926940
9MP0010094_abnormal_chromosome_stability3.14153075
10MP0003172_abnormal_lysosome_physiology3.08391623
11MP0002254_reproductive_system_inflammat2.96834195
12MP0005083_abnormal_biliary_tract2.91946788
13MP0003195_calcinosis2.91842196
14MP0005085_abnormal_gallbladder_physiolo2.82606125
15MP0003806_abnormal_nucleotide_metabolis2.77649938
16MP0004957_abnormal_blastocyst_morpholog2.68203917
17MP0008058_abnormal_DNA_repair2.51267598
18MP0003941_abnormal_skin_development2.37364624
19MP0008007_abnormal_cellular_replicative2.12719109
20MP0008875_abnormal_xenobiotic_pharmacok2.11522934
21MP0010329_abnormal_lipoprotein_level2.11483973
22MP0008932_abnormal_embryonic_tissue2.11007131
23MP0005332_abnormal_amino_acid2.10790856
24MP0001666_abnormal_nutrient_absorption2.10322530
25MP0009643_abnormal_urine_homeostasis1.88791568
26MP0003077_abnormal_cell_cycle1.88464949
27MP0003724_increased_susceptibility_to1.82508853
28MP0003300_gastrointestinal_ulcer1.80922640
29MP0005464_abnormal_platelet_physiology1.79885799
30MP0003718_maternal_effect1.78173118
31MP0000604_amyloidosis1.72855349
32MP0004272_abnormal_basement_membrane1.71996142
33MP0005670_abnormal_white_adipose1.71432065
34MP0003329_amyloid_beta_deposits1.71003551
35MP0002118_abnormal_lipid_homeostasis1.66661772
36MP0003656_abnormal_erythrocyte_physiolo1.66520069
37MP0005319_abnormal_enzyme/_coenzyme1.64285570
38MP0000609_abnormal_liver_physiology1.63377374
39MP0009697_abnormal_copulation1.62503013
40MP0005257_abnormal_intraocular_pressure1.62184360
41MP0005220_abnormal_exocrine_pancreas1.61822827
42MP0003279_aneurysm1.57073900
43MP0003786_premature_aging1.51681439
44MP0004019_abnormal_vitamin_homeostasis1.51621214
45MP0003186_abnormal_redox_activity1.50676027
46MP0008961_abnormal_basal_metabolism1.49029339
47MP0001730_embryonic_growth_arrest1.46896515
48MP0001764_abnormal_homeostasis1.44446138
49MP0002909_abnormal_adrenal_gland1.43875724
50MP0002837_dystrophic_cardiac_calcinosis1.41489145
51MP0000490_abnormal_crypts_of1.41314865
52MP0005584_abnormal_enzyme/coenzyme_acti1.40893945
53MP0005451_abnormal_body_composition1.39573385
54MP0001849_ear_inflammation1.38111005
55MP0002693_abnormal_pancreas_physiology1.37709096
56MP0003566_abnormal_cell_adhesion1.37304671
57MP0003252_abnormal_bile_duct1.35494083
58MP0002877_abnormal_melanocyte_morpholog1.34167638
59MP0008469_abnormal_protein_level1.32213997
60MP0004043_abnormal_pH_regulation1.32069016
61MP0008260_abnormal_autophagy1.30238062
62MP0000013_abnormal_adipose_tissue1.30168953
63MP0003183_abnormal_peptide_metabolism1.29399850
64MP0000371_diluted_coat_color1.24327208
65MP0001944_abnormal_pancreas_morphology1.24064575
66MP0000465_gastrointestinal_hemorrhage1.22429749
67MP0006035_abnormal_mitochondrial_morpho1.21443448
68MP0000685_abnormal_immune_system1.21216654
69MP0005636_abnormal_mineral_homeostasis1.21131943
70MP0003436_decreased_susceptibility_to1.20152153
71MP0009333_abnormal_splenocyte_physiolog1.20038301
72MP0002078_abnormal_glucose_homeostasis1.18169689
73MP0000313_abnormal_cell_death1.14066067
74MP0002419_abnormal_innate_immunity1.11787339
75MP0000350_abnormal_cell_proliferation1.10457574
76MP0001533_abnormal_skeleton_physiology1.09168972
77MP0005408_hypopigmentation1.08523274
78MP0005075_abnormal_melanosome_morpholog1.07826602
79MP0000015_abnormal_ear_pigmentation1.05811249
80MP0009384_cardiac_valve_regurgitation1.05695287
81MP0001765_abnormal_ion_homeostasis1.05289860
82MP0000598_abnormal_liver_morphology1.05164497
83MP0005671_abnormal_response_to1.04198555
84MP0002080_prenatal_lethality1.03954412
85MP0001756_abnormal_urination1.03405461
86MP0001845_abnormal_inflammatory_respons1.03067205
87MP0002019_abnormal_tumor_incidence1.02168991
88MP0006036_abnormal_mitochondrial_physio1.01757623
89MP0005501_abnormal_skin_physiology1.01432087
90MP0005000_abnormal_immune_tolerance1.00976075
91MP0005025_abnormal_response_to1.00567827
92MP0001243_abnormal_dermal_layer1.00567413
93MP0001672_abnormal_embryogenesis/_devel1.00131821
94MP0005380_embryogenesis_phenotype1.00131821
95MP0001853_heart_inflammation0.99103029
96MP0009053_abnormal_anal_canal0.98153861
97MP0003763_abnormal_thymus_physiology0.96990390
98MP0002723_abnormal_immune_serum0.96772945
99MP0009763_increased_sensitivity_to0.96481043
100MP0002132_abnormal_respiratory_system0.96304813
101MP0001881_abnormal_mammary_gland0.95508260
102MP0002090_abnormal_vision0.94926450
103MP0002060_abnormal_skin_morphology0.94908057
104MP0001790_abnormal_immune_system0.94778128
105MP0005387_immune_system_phenotype0.94778128
106MP0003705_abnormal_hypodermis_morpholog0.94253248
107MP0009642_abnormal_blood_homeostasis0.93577749
108MP0003315_abnormal_perineum_morphology0.93238938
109MP0000678_abnormal_parathyroid_gland0.92566222
110MP0001697_abnormal_embryo_size0.92481806
111MP0003075_altered_response_to0.92042223
112MP0000358_abnormal_cell_content/0.91550614
113MP0000689_abnormal_spleen_morphology0.91467217
114MP0004947_skin_inflammation0.90669090
115MP0006082_CNS_inflammation0.89566062
116MP0002136_abnormal_kidney_physiology0.89369520
117MP0001800_abnormal_humoral_immune0.89074476
118MP0010030_abnormal_orbit_morphology0.88965729
119MP0009785_altered_susceptibility_to0.88247300
120MP0005395_other_phenotype0.87274613
121MP0008438_abnormal_cutaneous_collagen0.86712043
122MP0001835_abnormal_antigen_presentation0.86649120
123MP0002420_abnormal_adaptive_immunity0.86213550
124MP0003866_abnormal_defecation0.86001207
125MP0002933_joint_inflammation0.85399627
126MP0004233_abnormal_muscle_weight0.85367456
127MP0010307_abnormal_tumor_latency0.85196057
128MP0002160_abnormal_reproductive_system0.84922748
129MP0009672_abnormal_birth_weight0.84567268
130MP0002452_abnormal_antigen_presenting0.84380111
131MP0002938_white_spotting0.84043171
132MP0003984_embryonic_growth_retardation0.83224876
133MP0001819_abnormal_immune_cell0.82849351
134MP0010352_gastrointestinal_tract_polyps0.81280438
135MP0003868_abnormal_feces_composition0.80717461
136MP0001348_abnormal_lacrimal_gland0.80422979
137MP0005023_abnormal_wound_healing0.78850904
138MP0006054_spinal_hemorrhage0.77669123
139MP0001915_intracranial_hemorrhage0.77662360
140MP0002396_abnormal_hematopoietic_system0.77195398
141MP0002086_abnormal_extraembryonic_tissu0.77032427
142MP0002088_abnormal_embryonic_growth/wei0.76647119
143MP0001661_extended_life_span0.76076201
144MP0002111_abnormal_tail_morphology0.74920649
145MP0002722_abnormal_immune_system0.74112334
146MP0001216_abnormal_epidermal_layer0.73603890
147MP0003303_peritoneal_inflammation0.73530415
148MP0005666_abnormal_adipose_tissue0.73176530
149MP0000716_abnormal_immune_system0.72460658
150MP0003448_altered_tumor_morphology0.71742482
151MP0004782_abnormal_surfactant_physiolog0.70764200
152MP0005167_abnormal_blood-brain_barrier0.69666587
153MP0002398_abnormal_bone_marrow0.69332908
154MP0003690_abnormal_glial_cell0.69330807
155MP0003011_delayed_dark_adaptation0.69181150
156MP0002295_abnormal_pulmonary_circulatio0.68825203
157MP0001545_abnormal_hematopoietic_system0.68728187
158MP0005397_hematopoietic_system_phenotyp0.68728187
159MP0002085_abnormal_embryonic_tissue0.67633352
160MP0005384_cellular_phenotype0.67325428
161MP0000538_abnormal_urinary_bladder0.65988136
162MP0001186_pigmentation_phenotype0.65452026
163MP0002653_abnormal_ependyma_morphology0.65368046
164MP0009278_abnormal_bone_marrow0.64999540
165MP0002075_abnormal_coat/hair_pigmentati0.64524523
166MP0002429_abnormal_blood_cell0.64391188

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)4.41496658
2* Type I transferrin isoform profile (HP:0003642)4.01250161
3Dysostosis multiplex (HP:0000943)3.64862138
4Xanthomatosis (HP:0000991)3.49880752
5Reduced antithrombin III activity (HP:0001976)3.47489902
6Vacuolated lymphocytes (HP:0001922)3.44766341
7Gout (HP:0001997)3.43077720
8Hepatic necrosis (HP:0002605)3.40406256
9Generalized aminoaciduria (HP:0002909)3.36186987
10Abnormality of the intrinsic pathway (HP:0010989)3.34842301
11Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.26485685
12Hepatocellular necrosis (HP:0001404)3.26066768
13Hypoglycemic coma (HP:0001325)3.24252602
14Microvesicular hepatic steatosis (HP:0001414)3.19737447
15Rough bone trabeculation (HP:0100670)3.14478348
16Mucopolysacchariduria (HP:0008155)3.07768428
17Urinary glycosaminoglycan excretion (HP:0003541)3.07768428
18Deep venous thrombosis (HP:0002625)3.02411517
19Abnormal number of erythroid precursors (HP:0012131)2.92629298
20Hypoplasia of the pons (HP:0012110)2.90977562
21Abnormality of mucopolysaccharide metabolism (HP:0011020)2.87414525
22Abnormality of polysaccharide metabolism (HP:0011012)2.87414525
23Abnormality of glycosaminoglycan metabolism (HP:0004371)2.87414525
24Intrahepatic cholestasis (HP:0001406)2.87410729
25Microretrognathia (HP:0000308)2.85469522
26Ketosis (HP:0001946)2.85448263
27Increased cerebral lipofuscin (HP:0011813)2.84791717
28Premature rupture of membranes (HP:0001788)2.83839988
29Testicular atrophy (HP:0000029)2.78989810
30Abnormality of fatty-acid metabolism (HP:0004359)2.75323112
31* Nonimmune hydrops fetalis (HP:0001790)2.74758879
32Hyperlipoproteinemia (HP:0010980)2.74647794
33Increased neuronal autofluorescent lipopigment (HP:0002074)2.73709012
34Hypoglycemic seizures (HP:0002173)2.73550447
35Abnormality of the pons (HP:0007361)2.67893245
36Hypokinesia (HP:0002375)2.67855143
37Vertebral compression fractures (HP:0002953)2.63528583
38Abnormality of the common coagulation pathway (HP:0010990)2.62750414
39Brushfield spots (HP:0001088)2.59015372
40Ketoacidosis (HP:0001993)2.58136268
41Late onset (HP:0003584)2.57787153
42Abnormal trabecular bone morphology (HP:0100671)2.53405980
43Decreased activity of mitochondrial respiratory chain (HP:0008972)2.52596933
44Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.52596933
45Progressive neurologic deterioration (HP:0002344)2.51797573
46Abnormality of glycolipid metabolism (HP:0010969)2.51687334
47Abnormality of liposaccharide metabolism (HP:0010968)2.51687334
48Abnormality of glycosphingolipid metabolism (HP:0004343)2.51687334
49Hyperglycinuria (HP:0003108)2.51269464
50Complement deficiency (HP:0004431)2.47571979
51Progressive muscle weakness (HP:0003323)2.42072632
52Conjugated hyperbilirubinemia (HP:0002908)2.40756655
53Abnormality of monocarboxylic acid metabolism (HP:0010996)2.40624184
54Multiple enchondromatosis (HP:0005701)2.38297409
55Prolonged neonatal jaundice (HP:0006579)2.38150988
56Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.36226680
57Abnormality of purine metabolism (HP:0004352)2.35558066
58Selective tooth agenesis (HP:0001592)2.33973479
59Hypobetalipoproteinemia (HP:0003563)2.33168014
60Methylmalonic aciduria (HP:0012120)2.32687725
61Increased serum lactate (HP:0002151)2.31639711
62Myocardial infarction (HP:0001658)2.30079689
63Hyperbilirubinemia (HP:0002904)2.29356367
64Hyperammonemia (HP:0001987)2.29207483
65Systemic lupus erythematosus (HP:0002725)2.28687757
66Pancytopenia (HP:0001876)2.27601272
67Poor head control (HP:0002421)2.27198727
68Retinal atrophy (HP:0001105)2.27132349
69Prolonged partial thromboplastin time (HP:0003645)2.26757563
70Abnormality of cells of the erythroid lineage (HP:0012130)2.24686852
71Hypoalphalipoproteinemia (HP:0003233)2.23329990
72Global brain atrophy (HP:0002283)2.22473756
73Thoracic kyphosis (HP:0002942)2.22084136
74Sensorimotor neuropathy (HP:0007141)2.21872077
75Hypolipoproteinemia (HP:0010981)2.19023773
76Symptomatic seizures (HP:0011145)2.18126397
77CNS demyelination (HP:0007305)2.17490655
78Abnormality of sulfur amino acid metabolism (HP:0004339)2.17351190
79Premature ovarian failure (HP:0008209)2.15888300
80Dicarboxylic aciduria (HP:0003215)2.15855429
81Abnormality of dicarboxylic acid metabolism (HP:0010995)2.15855429
82Epiphyseal stippling (HP:0010655)2.15606381
83Abnormality of serine family amino acid metabolism (HP:0010894)2.15384211
84Abnormality of glycine metabolism (HP:0010895)2.15384211
85Hypoplasia of the capital femoral epiphysis (HP:0003090)2.15345145
86Trismus (HP:0000211)2.10561989
87Hyperinsulinemic hypoglycemia (HP:0000825)2.08861505
88Abnormality of methionine metabolism (HP:0010901)2.07786360
89Protuberant abdomen (HP:0001538)2.06921027
90Lactic acidosis (HP:0003128)2.05062123
91Spastic paraparesis (HP:0002313)2.04418277
92Increased CSF lactate (HP:0002490)2.03725249
93Opisthotonus (HP:0002179)2.03104745
94Acute encephalopathy (HP:0006846)2.03000627
95Agammaglobulinemia (HP:0004432)2.00888744
96Abnormality of nucleobase metabolism (HP:0010932)1.99675424
97Increased serum pyruvate (HP:0003542)1.99606413
98Large for gestational age (HP:0001520)1.99168838
99Fat malabsorption (HP:0002630)1.99127862
100Asymmetric septal hypertrophy (HP:0001670)1.97899797
101Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.97274550
102Interstitial pulmonary disease (HP:0006530)1.96546965
103Albinism (HP:0001022)1.95699160
104Abnormality of glutamine family amino acid metabolism (HP:0010902)1.95283649
105Dysautonomia (HP:0002459)1.94741308
106Abnormality of complement system (HP:0005339)1.94242174
107Glomerulonephritis (HP:0000099)1.91217629
108Esophageal neoplasm (HP:0100751)1.89910769
109Neoplasm of head and neck (HP:0012288)1.89910769
110Abnormality of glycolysis (HP:0004366)1.89907248
111Redundant skin (HP:0001582)1.89843737
112Mitral stenosis (HP:0001718)1.89506780
113Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.89202007
114* Abnormal protein glycosylation (HP:0012346)1.89022784
115* Abnormal glycosylation (HP:0012345)1.89022784
116* Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.89022784
117* Abnormal protein N-linked glycosylation (HP:0012347)1.89022784
118Beaking of vertebral bodies (HP:0004568)1.88904125
119Abnormality of the odontoid process (HP:0003310)1.87168296
120Mitochondrial inheritance (HP:0001427)1.86888173
121Gastrointestinal inflammation (HP:0004386)1.85671091
122Secondary amenorrhea (HP:0000869)1.84026337
123Cortical visual impairment (HP:0100704)1.82626003
124Abnormality of dentin (HP:0010299)1.82594390
125Abnormal mitochondria in muscle tissue (HP:0008316)1.82357238
126Increased muscle lipid content (HP:0009058)1.82313054
127Loss of speech (HP:0002371)1.82131865
128Increased serum ferritin (HP:0003281)1.81251055
129Lipid accumulation in hepatocytes (HP:0006561)1.81082741
130Joint stiffness (HP:0001387)1.80639245
131Abnormality of the pancreatic islet cells (HP:0006476)1.80359814
132Abnormality of endocrine pancreas physiology (HP:0012093)1.80359814
133Aplastic anemia (HP:0001915)1.79353047
134Hypergonadotropic hypogonadism (HP:0000815)1.79091183
135Birth length less than 3rd percentile (HP:0003561)1.78959609
136Sparse eyelashes (HP:0000653)1.78927117
137Neurofibrillary tangles (HP:0002185)1.78852845
138Vascular calcification (HP:0004934)1.78514821
139Irritability (HP:0000737)1.77068929
140Hyperglycemia (HP:0003074)1.75847331
141Abnormality of the preputium (HP:0100587)1.75251407
142Abnormal enzyme/coenzyme activity (HP:0012379)1.75129325
143Chromosomal breakage induced by crosslinking agents (HP:0003221)1.75085924
144Meckel diverticulum (HP:0002245)1.75041977
145Abnormal epiphyseal ossification (HP:0010656)1.74402769
146Ocular albinism (HP:0001107)1.74249735
147IgG deficiency (HP:0004315)1.73970967
148Generalized amyotrophy (HP:0003700)1.73185585
149Acute necrotizing encephalopathy (HP:0006965)1.72505512
150Abnormality of transition element cation homeostasis (HP:0011030)1.72112187
151Abnormal tarsal ossification (HP:0008369)1.71834851
152Horseshoe kidney (HP:0000085)1.71782289
153Cardiomegaly (HP:0001640)1.71283784
154Pancreatitis (HP:0001733)1.71106798
155Hypoplasia of the thymus (HP:0000778)1.70581898
156Cardiovascular calcification (HP:0011915)1.70461968
157* Death in infancy (HP:0001522)1.69999572
158Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.68233960
159Tongue fasciculations (HP:0001308)1.67447048
160Abnormality of the ileum (HP:0001549)1.65033794
161Squamous cell carcinoma (HP:0002860)1.63861276
162Abnormality of homocysteine metabolism (HP:0010919)1.62540805
163Homocystinuria (HP:0002156)1.62540805
164Petechiae (HP:0000967)1.62156166
165Increased hepatocellular lipid droplets (HP:0006565)1.61430859
166Increased intramyocellular lipid droplets (HP:0012240)1.60878121
167Entropion (HP:0000621)1.59548402
168Stridor (HP:0010307)1.58980778

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK4.49435354
2BUB14.41943535
3TRIB33.98993484
4ERN13.90125533
5VRK23.72760623
6IRAK33.16618537
7PKN22.99355690
8ZAP702.76043136
9MAP4K12.53370708
10PBK2.26447358
11SRPK12.19268603
12BLK2.14138171
13FLT32.13319914
14TESK12.09961464
15SMG12.09946181
16TSSK62.07024039
17ZAK2.04187018
18TLK12.03790210
19RIPK12.03771465
20KDR1.94965348
21SCYL21.91223865
22LIMK11.81554045
23NME21.81010989
24NEK11.79474977
25EIF2AK31.76943035
26TAOK31.75227037
27NME11.72679562
28TTK1.70452972
29JAK31.66018415
30EEF2K1.60206531
31MST1R1.55619283
32TYK21.53831352
33JAK11.53483569
34CDC71.53136094
35TGFBR21.51359480
36TBK11.50278689
37MST41.46357591
38TESK21.40834506
39EPHA21.35950872
40MAP3K11.34890160
41MAP2K21.33928023
42MAP2K31.32826837
43KSR21.32247838
44KIT1.29803350
45FGFR41.29339668
46GRK61.28355380
47CDK71.27439793
48EIF2AK11.24215937
49MAPKAPK31.22931656
50STK161.20483878
51NLK1.17832960
52LRRK21.15962667
53ARAF1.14409449
54VRK11.14192664
55SIK11.12387738
56BTK1.07717521
57MET1.07126437
58JAK21.06045558
59PASK1.02955205
60IRAK41.02432198
61TAF10.99809846
62INSRR0.99746152
63BRSK20.97136381
64PTK60.96422277
65AURKA0.95469493
66CHEK20.95284041
67AURKB0.93917128
68EPHB10.92713831
69NEK20.92703440
70PLK10.92623917
71SYK0.92214265
72FES0.92005652
73ATR0.91830398
74HIPK20.91804642
75CSF1R0.91385384
76BRSK10.88065206
77PIM20.87444495
78MOS0.86312427
79PIK3CG0.83998284
80IKBKE0.83968461
81ERBB40.82398300
82TEC0.81690412
83MAP3K130.80783508
84PRKCI0.80681756
85MAPK150.80332733
86TXK0.79080830
87MAP3K110.76177125
88IRAK10.76115380
89RPS6KA50.75430294
90STK40.75021778
91NTRK10.72280929
92NEK90.71492313
93LYN0.70800538
94PLK30.69054089
95PDK10.68749262
96MAP3K20.67227095
97EIF2AK20.65843231
98CDK40.65480527
99PDPK10.63117571
100MAP3K100.62951905
101PLK40.62699600
102PRKCH0.62641423
103CAMKK20.62384266
104CDK80.62313493
105MAP2K10.62268916
106CLK10.62177177
107STK100.62162911
108IRAK20.61770372
109ABL20.61347770
110NUAK10.61094447
111LCK0.60244895
112ITK0.59800708
113MARK30.59774552
114RPS6KA40.57582951
115DAPK10.56933694
116BRAF0.56093708
117DYRK30.55734228
118WEE10.55382944
119MAPK120.54546679
120MAP3K90.53515380
121PAK10.53279217
122CHEK10.52511777
123RPS6KB20.50991274
124RAF10.50922145
125GRK10.50344402
126CSNK2A10.49477705
127MAP3K30.49271843
128MAP4K20.48847344
129PAK40.48129041
130TRIM280.47778752
131PDK20.47047826
132CSNK1G30.46533877
133MAPK110.45507960
134MAPKAPK50.45210200
135CDK120.44891692
136RET0.44681506
137IKBKB0.44612198
138PAK20.42106719
139WNK40.42040943
140ILK0.41667853
141PRKCD0.41125793
142HCK0.39760988
143TGFBR10.38515413
144ADRBK20.37446782
145CSK0.36361564
146MKNK10.34793420
147CSNK2A20.34771626
148RPS6KA20.34761497
149TNIK0.34393686
150PRKG20.34157140
151BRD40.34020407
152ALK0.33520657
153AKT20.33275204
154PTK20.32993705
155TTN0.32646991
156RIPK40.32559477
157CSNK1A1L0.31682532
158MATK0.31555441
159MAPKAPK20.31237596
160CAMKK10.31063337
161MAP3K80.29747694

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.27306221
2Maturity onset diabetes of the young_Homo sapiens_hsa049503.08222426
3Protein export_Homo sapiens_hsa030602.86167249
4Primary bile acid biosynthesis_Homo sapiens_hsa001202.73434350
5Folate biosynthesis_Homo sapiens_hsa007902.64266497
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.56744511
7Base excision repair_Homo sapiens_hsa034102.52128120
8Sulfur relay system_Homo sapiens_hsa041222.38803164
9RNA polymerase_Homo sapiens_hsa030202.37440711
10Fatty acid degradation_Homo sapiens_hsa000712.31494976
11Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.28104067
12Sulfur metabolism_Homo sapiens_hsa009202.25610042
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.17531253
14Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.16808953
15Other glycan degradation_Homo sapiens_hsa005112.15503589
16Peroxisome_Homo sapiens_hsa041462.13246993
17Mismatch repair_Homo sapiens_hsa034302.08163921
18Selenocompound metabolism_Homo sapiens_hsa004502.08041830
19Vitamin B6 metabolism_Homo sapiens_hsa007502.07866758
20Lysosome_Homo sapiens_hsa041422.02979671
21Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.91843823
22Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.89307317
23Drug metabolism - other enzymes_Homo sapiens_hsa009831.87886314
24Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.87358042
25Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.81989346
26Homologous recombination_Homo sapiens_hsa034401.81258541
27Pentose phosphate pathway_Homo sapiens_hsa000301.80554823
28Nitrogen metabolism_Homo sapiens_hsa009101.76246368
29Tryptophan metabolism_Homo sapiens_hsa003801.67233367
30Fatty acid metabolism_Homo sapiens_hsa012121.62201406
31Nucleotide excision repair_Homo sapiens_hsa034201.60322198
322-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.59170423
33Glycosaminoglycan degradation_Homo sapiens_hsa005311.58888151
34Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.58078651
35Fructose and mannose metabolism_Homo sapiens_hsa000511.57797827
36Non-homologous end-joining_Homo sapiens_hsa034501.55844372
37Butanoate metabolism_Homo sapiens_hsa006501.52947091
38Galactose metabolism_Homo sapiens_hsa000521.50630274
39Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.47891407
40Spliceosome_Homo sapiens_hsa030401.45074374
41RNA transport_Homo sapiens_hsa030131.43333735
42Biosynthesis of amino acids_Homo sapiens_hsa012301.40370988
43Propanoate metabolism_Homo sapiens_hsa006401.40341704
44Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.40092067
45Complement and coagulation cascades_Homo sapiens_hsa046101.37643961
46Arginine biosynthesis_Homo sapiens_hsa002201.34395931
47Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.34303602
48Staphylococcus aureus infection_Homo sapiens_hsa051501.31993989
49Caffeine metabolism_Homo sapiens_hsa002321.31201569
50Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.31193577
51Cyanoamino acid metabolism_Homo sapiens_hsa004601.31157143
52ABC transporters_Homo sapiens_hsa020101.27110015
53Carbon metabolism_Homo sapiens_hsa012001.25924982
54Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.25009058
55Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.24009640
56* N-Glycan biosynthesis_Homo sapiens_hsa005101.20609773
57Ribosome_Homo sapiens_hsa030101.19354835
58Glycerolipid metabolism_Homo sapiens_hsa005611.18849697
59beta-Alanine metabolism_Homo sapiens_hsa004101.16538981
60Fanconi anemia pathway_Homo sapiens_hsa034601.16299560
61PPAR signaling pathway_Homo sapiens_hsa033201.13791811
62Pyruvate metabolism_Homo sapiens_hsa006201.12652825
63Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.08427857
64Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.08405666
65Purine metabolism_Homo sapiens_hsa002301.08284383
66Oxidative phosphorylation_Homo sapiens_hsa001901.07846413
67Fat digestion and absorption_Homo sapiens_hsa049751.06676941
68Cysteine and methionine metabolism_Homo sapiens_hsa002701.06216919
69Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.99855460
70Starch and sucrose metabolism_Homo sapiens_hsa005000.99828070
71Chemical carcinogenesis_Homo sapiens_hsa052040.94059458
72Fatty acid elongation_Homo sapiens_hsa000620.93616188
73Regulation of autophagy_Homo sapiens_hsa041400.92813671
74Arginine and proline metabolism_Homo sapiens_hsa003300.91934964
75Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.91128868
76Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.89068932
77Cell cycle_Homo sapiens_hsa041100.88101483
78Histidine metabolism_Homo sapiens_hsa003400.84579758
79Parkinsons disease_Homo sapiens_hsa050120.82344623
80Proteasome_Homo sapiens_hsa030500.74169465
81* Metabolic pathways_Homo sapiens_hsa011000.72873516
82Bile secretion_Homo sapiens_hsa049760.70500241
83Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.69017532
84Huntingtons disease_Homo sapiens_hsa050160.67968028
85Basal transcription factors_Homo sapiens_hsa030220.67268043
86Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.67208849
87Prion diseases_Homo sapiens_hsa050200.66252277
88Vitamin digestion and absorption_Homo sapiens_hsa049770.64279853
89Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.63911222
90Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.63503832
91Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.62671231
92Antigen processing and presentation_Homo sapiens_hsa046120.62524474
93Glycerophospholipid metabolism_Homo sapiens_hsa005640.62372343
94Steroid biosynthesis_Homo sapiens_hsa001000.62111982
95RNA degradation_Homo sapiens_hsa030180.61437107
96Systemic lupus erythematosus_Homo sapiens_hsa053220.61297011
97Glutathione metabolism_Homo sapiens_hsa004800.60713903
98Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.60416483
99Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.60177008
100Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.59263945
101p53 signaling pathway_Homo sapiens_hsa041150.59212621
102Carbohydrate digestion and absorption_Homo sapiens_hsa049730.56405724
103Sphingolipid metabolism_Homo sapiens_hsa006000.52652610
104Bladder cancer_Homo sapiens_hsa052190.52155451
105Phenylalanine metabolism_Homo sapiens_hsa003600.51063147
106Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.50898550
107Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.50116387
108mRNA surveillance pathway_Homo sapiens_hsa030150.45515542
109Insulin resistance_Homo sapiens_hsa049310.44435543
110Epstein-Barr virus infection_Homo sapiens_hsa051690.42388458
111Retinol metabolism_Homo sapiens_hsa008300.40867635
112Vibrio cholerae infection_Homo sapiens_hsa051100.40136013
113Tyrosine metabolism_Homo sapiens_hsa003500.39976508
114Renin-angiotensin system_Homo sapiens_hsa046140.37016276
115Collecting duct acid secretion_Homo sapiens_hsa049660.32536712
116Fatty acid biosynthesis_Homo sapiens_hsa000610.32520135
117Pancreatic secretion_Homo sapiens_hsa049720.31258441
118One carbon pool by folate_Homo sapiens_hsa006700.31241309
119SNARE interactions in vesicular transport_Homo sapiens_hsa041300.30767281
120Steroid hormone biosynthesis_Homo sapiens_hsa001400.30237494
121Alzheimers disease_Homo sapiens_hsa050100.30060713
122Protein digestion and absorption_Homo sapiens_hsa049740.28788889
123Shigellosis_Homo sapiens_hsa051310.28418582
124Adipocytokine signaling pathway_Homo sapiens_hsa049200.27070088
125Pyrimidine metabolism_Homo sapiens_hsa002400.26847825
126Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.24300157
127Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.23467325
128Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.23074915
129alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.22593270
130Primary immunodeficiency_Homo sapiens_hsa053400.22155585

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