ALDH3B1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the aldehyde dehydrogenase protein family. Aldehyde dehydrogenases are a family of isozymes that may play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. The encoded protein is able to oxidize long-chain fatty aldehydes in vitro, and may play a role in protection from oxidative stress. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axoneme assembly (GO:0035082)7.73557115
2neutrophil activation involved in immune response (GO:0002283)7.06071203
3left/right pattern formation (GO:0060972)7.00240665
4regulation of cilium movement (GO:0003352)6.22684498
5positive regulation by symbiont of host defense response (GO:0052509)5.90541515
6modulation by symbiont of host defense response (GO:0052031)5.90541515
7modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.90541515
8modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.90541515
9positive regulation by organism of defense response of other organism involved in symbiotic interact5.90541515
10modulation by symbiont of host immune response (GO:0052553)5.90541515
11response to xenobiotic stimulus (GO:0009410)5.79515169
12left/right axis specification (GO:0070986)5.53515144
13tolerance induction (GO:0002507)5.52578649
14respiratory burst (GO:0045730)5.42264530
15vitamin transmembrane transport (GO:0035461)5.34667025
16ventricular system development (GO:0021591)4.95294320
17diterpenoid biosynthetic process (GO:0016102)4.94444570
18response to peptidoglycan (GO:0032494)4.87666825
19pyrimidine-containing compound transmembrane transport (GO:0072531)4.65777535
20microtubule bundle formation (GO:0001578)4.62008612
21positive regulation of tolerance induction (GO:0002645)4.60681406
22neutrophil activation (GO:0042119)4.58107725
23negative regulation of humoral immune response (GO:0002921)4.51497653
24granulocyte activation (GO:0036230)4.47580796
25macrophage activation involved in immune response (GO:0002281)4.45167831
26negative regulation of immunoglobulin mediated immune response (GO:0002890)4.36497791
27negative regulation of B cell mediated immunity (GO:0002713)4.36497791
28regulation of germinal center formation (GO:0002634)4.34677387
29cilium organization (GO:0044782)4.25298197
30antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.20287237
31response to host immune response (GO:0052572)4.19253922
32response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.19253922
33one-carbon compound transport (GO:0019755)4.14267117
34hydrogen peroxide biosynthetic process (GO:0050665)4.13797883
35cilium assembly (GO:0042384)4.10610631
36leukocyte aggregation (GO:0070486)4.10485014
37intraciliary transport (GO:0042073)4.07408050
38negative regulation of T cell differentiation in thymus (GO:0033085)4.06555037
39regulation of tolerance induction (GO:0002643)4.01538530
40immunoglobulin mediated immune response (GO:0016064)3.97194674
41regulation of interferon-beta biosynthetic process (GO:0045357)3.91125271
42ethanol oxidation (GO:0006069)3.90305666
43regulation of interleukin-5 production (GO:0032674)3.87388199
44leukocyte migration involved in inflammatory response (GO:0002523)3.86237725
45lung epithelium development (GO:0060428)3.85209627
46cellular extravasation (GO:0045123)3.84478336
47positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.84381941
48production of molecular mediator involved in inflammatory response (GO:0002532)3.83277235
49glomerular epithelial cell development (GO:0072310)3.80038695
50myeloid cell activation involved in immune response (GO:0002275)3.75515554
51regulation of B cell receptor signaling pathway (GO:0050855)3.75161316
52response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.74653916
53response to host (GO:0075136)3.74653916
54response to host defenses (GO:0052200)3.74653916
55superoxide anion generation (GO:0042554)3.69498413
56regulation of microtubule-based movement (GO:0060632)3.67943298
57reactive oxygen species biosynthetic process (GO:1903409)3.67739082
58positive regulation of mast cell activation (GO:0033005)3.60847303
59positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.59742634
60microglial cell activation (GO:0001774)3.57692759
61establishment of apical/basal cell polarity (GO:0035089)3.56630471
62regulation of mast cell degranulation (GO:0043304)3.54470195
63protein localization to cilium (GO:0061512)3.53991804
64* primary alcohol catabolic process (GO:0034310)3.51835610
65regulation of interleukin-13 production (GO:0032656)3.43360074
66positive regulation of mast cell degranulation (GO:0043306)3.41253181
67positive regulation of mast cell activation involved in immune response (GO:0033008)3.41253181
68lipopolysaccharide-mediated signaling pathway (GO:0031663)3.41192686
69phagosome maturation (GO:0090382)3.39740965
70positive regulation of antigen processing and presentation (GO:0002579)3.39520855
71retinoic acid metabolic process (GO:0042573)3.39267571
72centriole assembly (GO:0098534)3.39255254
73regulation of mast cell activation involved in immune response (GO:0033006)3.35179159
74positive regulation of interferon-alpha production (GO:0032727)3.32143711
75detection of other organism (GO:0098543)3.31617432
76sperm capacitation (GO:0048240)3.30063234
77regulation of mast cell activation (GO:0033003)3.29205980
78neutrophil mediated immunity (GO:0002446)3.27219853
79leukocyte mediated cytotoxicity (GO:0001909)3.26499570
80regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.24942595
81iron ion import (GO:0097286)3.20939118
82response to muramyl dipeptide (GO:0032495)3.20430136
83regulation of interleukin-6 biosynthetic process (GO:0045408)3.18040498
84regulation of leukocyte degranulation (GO:0043300)3.16432484
85regulation of dendritic cell antigen processing and presentation (GO:0002604)3.15437978
86positive regulation of leukocyte degranulation (GO:0043302)3.15243079
87* ethanol metabolic process (GO:0006067)3.15034091
88cellular component assembly involved in morphogenesis (GO:0010927)3.14480151
89detection of molecule of bacterial origin (GO:0032490)3.14253958
90terpenoid biosynthetic process (GO:0016114)3.13290167
91regulation of interferon-alpha production (GO:0032647)3.13168844
92amyloid precursor protein catabolic process (GO:0042987)3.13061212
93cellular response to zinc ion (GO:0071294)3.12716728
94cell projection assembly (GO:0030031)3.11942604
95macrophage activation (GO:0042116)3.09483721
96positive regulation of cellular amide metabolic process (GO:0034250)3.08827172
97hypotonic response (GO:0006971)3.06591659
98T-helper 1 type immune response (GO:0042088)3.06126958
99response to fungus (GO:0009620)3.05479510
100positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610813.04500106
101regulation of antigen processing and presentation (GO:0002577)3.04159516
102neutrophil chemotaxis (GO:0030593)3.02925107
103low-density lipoprotein particle clearance (GO:0034383)3.02789743
104regulation of syncytium formation by plasma membrane fusion (GO:0060142)3.01773358
105positive regulation of monocyte chemotaxis (GO:0090026)3.01537416
106microtubule-based movement (GO:0007018)2.99880043
107apoptotic cell clearance (GO:0043277)2.98551628
108positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.97777944
109O-glycan processing (GO:0016266)2.97639193
110regulation of myeloid leukocyte mediated immunity (GO:0002886)2.96482966
111neutrophil migration (GO:1990266)2.95339530
112cilium morphogenesis (GO:0060271)2.95328614
113detection of external biotic stimulus (GO:0098581)2.93535268
114leukocyte degranulation (GO:0043299)2.92246514
115leukotriene metabolic process (GO:0006691)2.91964112
116establishment of monopolar cell polarity (GO:0061162)2.91668070
117establishment or maintenance of monopolar cell polarity (GO:0061339)2.91668070
118negative regulation of mast cell activation (GO:0033004)2.90511002
119nucleoside diphosphate phosphorylation (GO:0006165)2.90428299
120progesterone metabolic process (GO:0042448)2.89769172
121regulation of toll-like receptor 4 signaling pathway (GO:0034143)2.89725584
122detection of bacterium (GO:0016045)2.89623877
123sequestering of metal ion (GO:0051238)2.89576133
124regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.88369670
125retinol metabolic process (GO:0042572)2.88116590
126negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.86852864
127positive regulation of macrophage cytokine production (GO:0060907)2.86581230
128regulation of mononuclear cell migration (GO:0071675)2.82933061
129natural killer cell mediated cytotoxicity (GO:0042267)2.82052724
130natural killer cell mediated immunity (GO:0002228)2.82052724
131positive regulation of toll-like receptor signaling pathway (GO:0034123)2.81986206
132regulation of interleukin-8 biosynthetic process (GO:0045414)2.80118086
133antigen processing and presentation of endogenous antigen (GO:0019883)2.79661683
134pinocytosis (GO:0006907)2.76428979
135regulation of monocyte chemotaxis (GO:0090025)2.75031770
136cytoplasmic microtubule organization (GO:0031122)2.72810661
137regulation of cholesterol storage (GO:0010885)2.72686009
138myeloid leukocyte activation (GO:0002274)2.71967618
139positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.71608730
140granulocyte chemotaxis (GO:0071621)2.71105591
141negative regulation of lymphocyte mediated immunity (GO:0002707)2.70498586
142exogenous drug catabolic process (GO:0042738)2.70387068
143leukocyte cell-cell adhesion (GO:0007159)2.65691979
144Arp2/3 complex-mediated actin nucleation (GO:0034314)2.63713027
145granulocyte migration (GO:0097530)2.63426179
146regulation of autophagic vacuole assembly (GO:2000785)2.63091682
147glutathione derivative metabolic process (GO:1901685)2.63042633
148glutathione derivative biosynthetic process (GO:1901687)2.63042633
149negative regulation of myeloid cell apoptotic process (GO:0033033)2.61971676
150response to lipoprotein particle (GO:0055094)2.60616884
151positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.60278313
152negative regulation of interleukin-17 production (GO:0032700)2.59419143
153negative regulation of interleukin-6 production (GO:0032715)2.59208113
154regulation of podosome assembly (GO:0071801)2.58611716
155hydrogen peroxide catabolic process (GO:0042744)2.58404688
156B cell mediated immunity (GO:0019724)2.58223864
157lipoxygenase pathway (GO:0019372)2.58043467
158negative regulation of adaptive immune response (GO:0002820)2.57748861
159positive regulation of extracellular matrix organization (GO:1903055)2.57439055
160eosinophil chemotaxis (GO:0048245)2.56704177
161detection of biotic stimulus (GO:0009595)2.53462729
162negative regulation of interleukin-12 production (GO:0032695)2.51998947
163regulation of response to osmotic stress (GO:0047484)2.51570630
164lateral ventricle development (GO:0021670)2.41156759
165negative regulation of inclusion body assembly (GO:0090084)2.38229382
166barbed-end actin filament capping (GO:0051016)2.36153211
167negative regulation of toll-like receptor signaling pathway (GO:0034122)2.35707860
168phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.34496039
169hydrogen peroxide metabolic process (GO:0042743)2.33668881
170carnitine metabolic process (GO:0009437)2.31229106
171negative regulation of leukocyte mediated immunity (GO:0002704)2.25731553
172regulation of vacuole organization (GO:0044088)2.25479248
173multicellular organismal water homeostasis (GO:0050891)2.24209939
174cellular response to exogenous dsRNA (GO:0071360)2.22694246
175dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.21923156
176carnitine transmembrane transport (GO:1902603)2.20881467
177regulation of metalloenzyme activity (GO:0048552)2.20347553
178glutathione biosynthetic process (GO:0006750)2.19300700
179oligosaccharide biosynthetic process (GO:0009312)2.19190462
180regulation of cilium assembly (GO:1902017)2.19148688
181* primary alcohol metabolic process (GO:0034308)2.17510402
182renal absorption (GO:0070293)2.17432405
183axonemal dynein complex assembly (GO:0070286)17.3077531
184cilium or flagellum-dependent cell motility (GO:0001539)14.7551561
185cilium movement (GO:0003341)12.0453566
186motile cilium assembly (GO:0044458)11.8925580
187epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)11.0986012
188epithelial cilium movement (GO:0003351)10.2039068

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_21731497_ChIP-ChIP_J774_Mouse6.49919723
2BP1_19119308_ChIP-ChIP_Hs578T_Human5.73029490
3IRF8_22096565_ChIP-ChIP_GC-B_Human4.87014878
4IRF8_27001747_Chip-Seq_BMDM_Mouse4.35345918
5SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse4.06194777
6TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.90253497
7Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.83683207
8* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.53728387
9* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.15126295
10MYB_21317192_ChIP-Seq_ERMYB_Mouse3.14203713
11FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.04794629
12NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.67358470
13* IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.64739570
14IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.54723144
15FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.52119465
16RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.44169255
17BRD4_27068464_Chip-Seq_AML-cells_Mouse2.34648473
18DROSHA_22980978_ChIP-Seq_HELA_Human2.33570474
19SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.32117226
20STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.24953961
21STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.05723514
22VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.93515984
23* SPI1_23547873_ChIP-Seq_NB4_Human1.89073207
24STAT4_19710469_ChIP-ChIP_TH1__Mouse1.89054189
25ESR1_21235772_ChIP-Seq_MCF-7_Human1.88836422
26PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.86042957
27THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.84614986
28SPI1_23127762_ChIP-Seq_K562_Human1.80490509
29CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.78735154
30VDR_24763502_ChIP-Seq_THP-1_Human1.77713867
31ESR1_20079471_ChIP-ChIP_T-47D_Human1.77371508
32SMC4_20622854_ChIP-Seq_HELA_Human1.77292279
33TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.76791176
34RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.72623613
35* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.70892966
36ELF1_20517297_ChIP-Seq_JURKAT_Human1.69104933
37* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.68886040
38NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.66759701
39RUNX_20019798_ChIP-Seq_JUKART_Human1.65808053
40CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.60542680
41VDR_24787735_ChIP-Seq_THP-1_Human1.60281654
42* RUNX1_27514584_Chip-Seq_MCF-7_Human1.59813054
43PU_27001747_Chip-Seq_BMDM_Mouse1.59699811
44RUNX1_22412390_ChIP-Seq_EML_Mouse1.59357903
45SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.59306048
46P68_20966046_ChIP-Seq_HELA_Human1.57309722
47* RACK7_27058665_Chip-Seq_MCF-7_Human1.55763647
48PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.55322465
49GATA2_21666600_ChIP-Seq_HMVEC_Human1.55292442
50MYB_26560356_Chip-Seq_TH2_Human1.53027168
51CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.48996494
52TP63_22573176_ChIP-Seq_HFKS_Human1.48380635
53EGR1_19374776_ChIP-ChIP_THP-1_Human1.48051110
54* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.47870480
55PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.46743430
56MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.45899929
57* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.45260060
58BCOR_27268052_Chip-Seq_Bcells_Human1.42519028
59STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.41510727
60STAT6_21828071_ChIP-Seq_BEAS2B_Human1.41474071
61* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.40545640
62FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.37545540
63KLF5_25053715_ChIP-Seq_YYC3_Human1.34031052
64* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.33483693
65* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.32842399
66* BCL6_27268052_Chip-Seq_Bcells_Human1.32289838
67VDR_21846776_ChIP-Seq_THP-1_Human1.31299944
68NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.30829692
69TRIM28_21343339_ChIP-Seq_HEK293_Human1.30704970
70CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.30331609
71TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.29877313
72* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.29271089
73TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.29149766
74MAF_26560356_Chip-Seq_TH1_Human1.28467876
75AHR_22903824_ChIP-Seq_MCF-7_Human1.27792434
76NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.27237194
77NRF2_20460467_ChIP-Seq_MEFs_Mouse1.27237194
78SCL_19346495_ChIP-Seq_HPC-7_Human1.26581234
79PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.25591818
80* RAD21_21589869_ChIP-Seq_MESCs_Mouse1.24296716
81PHF8_20622854_ChIP-Seq_HELA_Human1.24070896
82* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.21574367
83TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.21270330
84CTCF_20526341_ChIP-Seq_ESCs_Human1.19888619
85CDX2_19796622_ChIP-Seq_MESCs_Mouse1.19630565
86CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.19406129
87GATA3_27048872_Chip-Seq_THYMUS_Human1.19297584
88RARG_19884340_ChIP-ChIP_MEFs_Mouse1.19205447
89* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.19147469
90RXR_22158963_ChIP-Seq_LIVER_Mouse1.18951626
91* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.18198627
92P300_27268052_Chip-Seq_Bcells_Human1.17600520
93YY1_22570637_ChIP-Seq_MALME-3M_Human1.16704744
94BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.15638884
95SOX9_24532713_ChIP-Seq_HFSC_Mouse1.14866088
96* E2F1_20622854_ChIP-Seq_HELA_Human1.12917738
97GATA3_26560356_Chip-Seq_TH2_Human1.11630629
98* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.11204016
99ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.11112279
100VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.11044898
101* SOX2_20726797_ChIP-Seq_SW620_Human1.10642340
102EGR1_19032775_ChIP-ChIP_M12_Human1.09749463
103FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.09405639
104SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.07504364
105* SA1_27219007_Chip-Seq_ERYTHROID_Human1.07402797
106CREB1_26743006_Chip-Seq_LNCaP_Human1.05845792
107GATA4_25053715_ChIP-Seq_YYC3_Human1.05502294
108TP63_23658742_ChIP-Seq_EP156T_Human1.05465167
109AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.04363414
110GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.02293365
111GATA2_19941826_ChIP-Seq_K562_Human1.00599771
112GATA1_19941826_ChIP-Seq_K562_Human1.00528342
113UTX_26944678_Chip-Seq_JUKART_Human1.00170234
114TP53_22127205_ChIP-Seq_IMR90_Human1.00031927
115* ELK3_25401928_ChIP-Seq_HUVEC_Human0.99822817
116ZNF263_19887448_ChIP-Seq_K562_Human0.99675882
117SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99649147
118PPARA_22158963_ChIP-Seq_LIVER_Mouse0.99024142
119MYB_26560356_Chip-Seq_TH1_Human0.98593795
120TDRD3_21172665_ChIP-Seq_MCF-7_Human0.98557008
121CDX2_20551321_ChIP-Seq_CACO-2_Human0.98181217
122* P63_26484246_Chip-Seq_KERATINOCYTES_Human0.98121925
123LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.95492667
124FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.95436688
125SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.94799657
126IKZF1_21737484_ChIP-ChIP_HCT116_Human0.92320978
127PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.91632551
128JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.90553231
129GATA2_22383799_ChIP-Seq_G1ME_Mouse0.89821450
130GATA1_22383799_ChIP-Seq_G1ME_Mouse0.89227204
131JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.88078407
132SOX2_27498859_Chip-Seq_STOMACH_Mouse0.85873245
133RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.85857482
134ESR2_21235772_ChIP-Seq_MCF-7_Human0.85756079
135SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.85408087
136FOXO3_23340844_ChIP-Seq_DLD1_Human0.85241141
137CJUN_26792858_Chip-Seq_BT549_Human0.85226550
138GATA1_19941827_ChIP-Seq_MEL_Mouse0.83602422
139SPI1_20517297_ChIP-Seq_HL60_Human0.82494389
140* LXR_22292898_ChIP-Seq_THP-1_Human0.81271735
141GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.80858267
142KDM2B_26808549_Chip-Seq_SUP-B15_Human0.79726240
143CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.78440232
144GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.78228783
145STAT1_20625510_ChIP-Seq_HELA_Human0.77062742
146LXR_22158963_ChIP-Seq_LIVER_Mouse0.74053444
147SMRT_27268052_Chip-Seq_Bcells_Human0.73386094
148ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.72820642
149PPAR_26484153_Chip-Seq_NCI-H1993_Human0.72158620
150* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.72051449

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008875_abnormal_xenobiotic_pharmacok5.60088059
2MP0002132_abnormal_respiratory_system4.74715010
3MP0005058_abnormal_lysosome_morphology4.47355001
4MP0002653_abnormal_ependyma_morphology4.23978860
5MP0003436_decreased_susceptibility_to3.86101660
6MP0001835_abnormal_antigen_presentation3.79546125
7MP0003303_peritoneal_inflammation3.77424245
8MP0002419_abnormal_innate_immunity3.34944611
9MP0009785_altered_susceptibility_to3.24072010
10MP0002148_abnormal_hypersensitivity_rea2.99272060
11MP0005000_abnormal_immune_tolerance2.84982193
12MP0006082_CNS_inflammation2.78399324
13MP0005025_abnormal_response_to2.74647676
14MP0005387_immune_system_phenotype2.62654871
15MP0001790_abnormal_immune_system2.62654871
16MP0003724_increased_susceptibility_to2.62113884
17MP0003183_abnormal_peptide_metabolism2.55076972
18MP0002452_abnormal_antigen_presenting2.41429365
19MP0001533_abnormal_skeleton_physiology2.34227481
20MP0009840_abnormal_foam_cell2.28597640
21MP0004043_abnormal_pH_regulation2.27622224
22MP0003172_abnormal_lysosome_physiology2.26946043
23MP0003191_abnormal_cellular_cholesterol2.17361660
24MP0002723_abnormal_immune_serum2.15385035
25MP0004510_myositis2.15333845
26MP0000685_abnormal_immune_system2.15284445
27MP0000920_abnormal_myelination2.11689233
28MP0001800_abnormal_humoral_immune2.11385200
29MP0003075_altered_response_to2.11261644
30MP0005623_abnormal_meninges_morphology2.00399686
31MP0001819_abnormal_immune_cell1.99107752
32MP0002420_abnormal_adaptive_immunity1.98518180
33MP0005464_abnormal_platelet_physiology1.98286110
34MP0003690_abnormal_glial_cell1.95095759
35MP0000343_altered_response_to1.91084480
36MP0000604_amyloidosis1.89469725
37MP0002405_respiratory_system_inflammati1.89216478
38MP0004133_heterotaxia1.84454495
39MP0009780_abnormal_chondrocyte_physiolo1.83423600
40MP0001845_abnormal_inflammatory_respons1.73209078
41MP0009278_abnormal_bone_marrow1.72958318
42MP0009764_decreased_sensitivity_to1.70308355
43MP0004019_abnormal_vitamin_homeostasis1.68080631
44MP0004947_skin_inflammation1.65974273
45MP0008260_abnormal_autophagy1.65645411
46MP0005671_abnormal_response_to1.65060882
47MP0003806_abnormal_nucleotide_metabolis1.64547850
48MP0001958_emphysema1.62883936
49MP0005377_hearing/vestibular/ear_phenot1.62394706
50MP0003878_abnormal_ear_physiology1.62394706
51MP0001984_abnormal_olfaction1.61623716
52MP0003448_altered_tumor_morphology1.60513009
53MP0001851_eye_inflammation1.58415625
54MP0002168_other_aberrant_phenotype1.55783711
55MP0005167_abnormal_blood-brain_barrier1.54269349
56MP0004782_abnormal_surfactant_physiolog1.54080146
57MP0003300_gastrointestinal_ulcer1.53379934
58MP0008469_abnormal_protein_level1.46900632
59MP0001765_abnormal_ion_homeostasis1.45501824
60MP0005310_abnormal_salivary_gland1.45022016
61MP0002933_joint_inflammation1.43105130
62MP0005165_increased_susceptibility_to1.40985600
63MP0002998_abnormal_bone_remodeling1.36932394
64MP0008789_abnormal_olfactory_epithelium1.34079639
65MP0000383_abnormal_hair_follicle1.33843540
66MP0000716_abnormal_immune_system1.33713365
67MP0005166_decreased_susceptibility_to1.31337951
68MP0002139_abnormal_hepatobiliary_system1.24443220
69MP0001853_heart_inflammation1.23217533
70MP0005164_abnormal_response_to1.23034933
71MP0009333_abnormal_splenocyte_physiolog1.20059601
72MP0010155_abnormal_intestine_physiology1.19252661
73MP0005365_abnormal_bile_salt1.18373012
74MP0010678_abnormal_skin_adnexa1.17927915
75MP0008438_abnormal_cutaneous_collagen1.14703511
76MP0003950_abnormal_plasma_membrane1.14306584
77MP0000858_altered_metastatic_potential1.12878696
78MP0000681_abnormal_thyroid_gland1.10850010
79MP0003656_abnormal_erythrocyte_physiolo1.09217485
80MP0005390_skeleton_phenotype1.08534529
81MP0003566_abnormal_cell_adhesion1.08432230
82MP0001849_ear_inflammation1.07899815
83MP0002277_abnormal_respiratory_mucosa1.06188687
84MP0000678_abnormal_parathyroid_gland1.05251895
85MP0009643_abnormal_urine_homeostasis1.03737588
86MP0002282_abnormal_trachea_morphology1.01919931
87MP0003634_abnormal_glial_cell1.01814350
88MP0000689_abnormal_spleen_morphology1.01753847
89MP0002429_abnormal_blood_cell1.01675704
90MP0004883_abnormal_blood_vessel1.00961537
91MP0003186_abnormal_redox_activity1.00718497
92MP0002398_abnormal_bone_marrow0.99906088
93MP0000465_gastrointestinal_hemorrhage0.98464926
94MP0005174_abnormal_tail_pigmentation0.98249513
95MP0008004_abnormal_stomach_pH0.96146500
96MP0010234_abnormal_vibrissa_follicle0.95486217
97MP0003329_amyloid_beta_deposits0.94350667
98MP0003866_abnormal_defecation0.93956638
99MP0003453_abnormal_keratinocyte_physiol0.91276973
100MP0005636_abnormal_mineral_homeostasis0.91085765
101MP0001542_abnormal_bone_strength0.89181539
102MP0003195_calcinosis0.88672152
103MP0001545_abnormal_hematopoietic_system0.88076541
104MP0005397_hematopoietic_system_phenotyp0.88076541
105MP0000249_abnormal_blood_vessel0.87773985
106MP0005083_abnormal_biliary_tract0.86419234
107MP0002722_abnormal_immune_system0.82996457
108MP0002138_abnormal_hepatobiliary_system0.81896321
109MP0001873_stomach_inflammation0.81808292
110MP0005085_abnormal_gallbladder_physiolo0.81742707
111MP0002295_abnormal_pulmonary_circulatio0.80900443
112MP0009763_increased_sensitivity_to0.79409352
113MP0003091_abnormal_cell_migration0.78973073
114MP0005248_abnormal_Harderian_gland0.78751456
115MP0002006_tumorigenesis0.78507360
116MP0009765_abnormal_xenobiotic_induced0.78098090
117MP0005171_absent_coat_pigmentation0.77395390
118MP0002133_abnormal_respiratory_system0.76767157
119MP0005388_respiratory_system_phenotype0.76767157
120MP0005257_abnormal_intraocular_pressure0.75459284
121MP0005319_abnormal_enzyme/_coenzyme0.74326074
122MP0005395_other_phenotype0.73536044
123MP0003045_fibrosis0.73523874
124MP0005023_abnormal_wound_healing0.73256211
125MP0003795_abnormal_bone_structure0.71986279
126MP0002166_altered_tumor_susceptibility0.70120319
127MP0004742_abnormal_vestibular_system0.67871565
128MP0000015_abnormal_ear_pigmentation0.67843716
129MP0001663_abnormal_digestive_system0.67475658
130MP0002136_abnormal_kidney_physiology0.66751808
131MP0003828_pulmonary_edema0.65923093
132MP0005076_abnormal_cell_differentiation0.65089664
133MP0002090_abnormal_vision0.65081228
134MP0002160_abnormal_reproductive_system0.64044103
135MP0003279_aneurysm0.62976740
136MP0005410_abnormal_fertilization0.61520310
137MP0004185_abnormal_adipocyte_glucose0.60844825
138MP0000569_abnormal_digit_pigmentation0.60567919

Predicted human phenotypes

RankGene SetZ-score
1Rhinitis (HP:0012384)9.33860486
2Recurrent abscess formation (HP:0002722)7.43371244
3Eczematoid dermatitis (HP:0000976)7.20773411
4Chronic bronchitis (HP:0004469)7.19225006
5Bronchiectasis (HP:0002110)6.89432738
6Recurrent gram-negative bacterial infections (HP:0005420)6.59538544
7Recurrent bacterial skin infections (HP:0005406)6.41821303
8Abnormality of macrophages (HP:0004311)5.98662916
9Vacuolated lymphocytes (HP:0001922)5.52704824
10Increased cerebral lipofuscin (HP:0011813)4.86210300
11Increased neuronal autofluorescent lipopigment (HP:0002074)4.49804339
12Axonal loss (HP:0003447)4.44500814
13Recurrent sinusitis (HP:0011108)4.37106675
14Systemic lupus erythematosus (HP:0002725)4.33511147
15Chronic obstructive pulmonary disease (HP:0006510)4.29868007
16Obstructive lung disease (HP:0006536)4.29868007
17Interstitial pulmonary disease (HP:0006530)4.20382251
18Bronchitis (HP:0012387)4.13450619
19Dysostosis multiplex (HP:0000943)3.98153417
20Mediastinal lymphadenopathy (HP:0100721)3.97921233
21Chronic sinusitis (HP:0011109)3.97622423
22Recurrent skin infections (HP:0001581)3.96786147
23Infertility (HP:0000789)3.95181322
24Disinhibition (HP:0000734)3.89812068
25Gingivitis (HP:0000230)3.83119122
26Abnormality of liposaccharide metabolism (HP:0010968)3.75262124
27Abnormality of glycosphingolipid metabolism (HP:0004343)3.75262124
28Abnormality of glycolipid metabolism (HP:0010969)3.75262124
29Male infertility (HP:0003251)3.69128814
30Recurrent otitis media (HP:0000403)3.67542665
31Cellulitis (HP:0100658)3.65117199
32Stomatitis (HP:0010280)3.54611994
33Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.49690921
34Myositis (HP:0100614)3.40215043
35Elevated erythrocyte sedimentation rate (HP:0003565)3.22543621
36Hepatosplenomegaly (HP:0001433)3.18664348
37Orchitis (HP:0100796)3.15735167
38Loss of speech (HP:0002371)3.15123821
39Recurrent fungal infections (HP:0002841)3.13735592
40Occipital encephalocele (HP:0002085)3.07369033
41Pancreatic fibrosis (HP:0100732)3.00197658
42Atelectasis (HP:0100750)2.93927538
43True hermaphroditism (HP:0010459)2.92219450
44Osteomyelitis (HP:0002754)2.91192391
45Urticaria (HP:0001025)2.89588803
46Neurofibrillary tangles (HP:0002185)2.88340798
47Hyperactive renin-angiotensin system (HP:0000841)2.81833475
48Recurrent pneumonia (HP:0006532)2.78986709
49Optic neuritis (HP:0100653)2.78795958
50Retrobulbar optic neuritis (HP:0100654)2.78795958
51Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.73447167
52Mucopolysacchariduria (HP:0008155)2.71199519
53Urinary glycosaminoglycan excretion (HP:0003541)2.71199519
54Vasculitis (HP:0002633)2.68785660
55Autoimmune thrombocytopenia (HP:0001973)2.67847283
56Meningitis (HP:0001287)2.67080003
57Spontaneous hematomas (HP:0007420)2.64064003
58Glomerulonephritis (HP:0000099)2.63976844
59Cystic liver disease (HP:0006706)2.61435949
60Osteolytic defects of the phalanges of the hand (HP:0009771)2.53767810
61Osteolytic defects of the hand bones (HP:0009699)2.53767810
62Abnormality of midbrain morphology (HP:0002418)2.52269850
63Molar tooth sign on MRI (HP:0002419)2.52269850
64Chronic otitis media (HP:0000389)2.51145789
65Abnormality of polysaccharide metabolism (HP:0011012)2.48960680
66Abnormality of glycosaminoglycan metabolism (HP:0004371)2.48960680
67Abnormality of mucopolysaccharide metabolism (HP:0011020)2.48960680
68Peripheral demyelination (HP:0011096)2.48533901
69Pustule (HP:0200039)2.48243131
70Segmental peripheral demyelination/remyelination (HP:0003481)2.46674474
71Pancreatic cysts (HP:0001737)2.36644236
72J-shaped sella turcica (HP:0002680)2.35438063
73Recurrent viral infections (HP:0004429)2.29046385
74Supranuclear gaze palsy (HP:0000605)2.28267791
75Abnormality of the nasal mucosa (HP:0000433)2.23520238
76Recurrent lower respiratory tract infections (HP:0002783)2.21595359
77Periodontitis (HP:0000704)2.21188171
78Nephritis (HP:0000123)2.20508679
79Nephronophthisis (HP:0000090)2.20469504
80Hematochezia (HP:0002573)2.17919424
81Abnormality of the vasculature of the conjunctiva (HP:0008054)2.16364194
82Amyloidosis (HP:0011034)2.16216886
83Basal ganglia calcification (HP:0002135)2.08660234
84Absent frontal sinuses (HP:0002688)2.06538630
85Peripheral hypomyelination (HP:0007182)2.05145536
86Sepsis (HP:0100806)2.05073772
87Purpura (HP:0000979)2.04375397
88Nasal polyposis (HP:0100582)2.04360398
89Conjunctival telangiectasia (HP:0000524)2.03249690
90Recurrent bronchitis (HP:0002837)2.03230728
91Thick nail (HP:0001805)2.03052029
92Respiratory insufficiency due to defective ciliary clearance (HP:0200073)11.5988994
93Abnormal respiratory epithelium morphology (HP:0012253)10.6306211
94Abnormal respiratory motile cilium morphology (HP:0005938)10.6306211
95Dynein arm defect of respiratory motile cilia (HP:0012255)10.3635307
96Absent/shortened dynein arms (HP:0200106)10.3635307
97Abnormal respiratory motile cilium physiology (HP:0012261)10.1872127
98Abnormal ciliary motility (HP:0012262)10.0199737
99Pulmonary infiltrates (HP:0002113)1.99673088
100Recurrent cutaneous fungal infections (HP:0011370)1.99547689
101Chronic mucocutaneous candidiasis (HP:0002728)1.99547689
102Restrictive lung disease (HP:0002091)1.99100190
103Chronic hepatic failure (HP:0100626)1.96545809
104Inflammation of the large intestine (HP:0002037)1.96459963
105Postaxial foot polydactyly (HP:0001830)1.95100030
106Abnormality of complement system (HP:0005339)1.94378707
107Bone pain (HP:0002653)1.94184669
108Cerebral inclusion bodies (HP:0100314)1.93870576
109Myocardial infarction (HP:0001658)1.91764032
110Hemoptysis (HP:0002105)1.89705840
111Petechiae (HP:0000967)1.87064588
112Progressive neurologic deterioration (HP:0002344)1.87052880
113Joint hemorrhage (HP:0005261)1.86999648
114Bell-shaped thorax (HP:0001591)1.86527250
115Decreased circulating renin level (HP:0003351)1.86135337
116Congenital hepatic fibrosis (HP:0002612)1.85483223
117Pathologic fracture (HP:0002756)1.84751989
118Parakeratosis (HP:0001036)1.83060580
119Colitis (HP:0002583)1.82007295
120Hemorrhage of the eye (HP:0011885)1.79834532
121Leukocytosis (HP:0001974)1.79183339
122Nephropathy (HP:0000112)1.79073601
123Gastrointestinal stroma tumor (HP:0100723)1.78740037
124Thoracic kyphosis (HP:0002942)1.78604968
125IgM deficiency (HP:0002850)1.78495033
126Prostate neoplasm (HP:0100787)1.76969887
127Abnormality of the lumbar spine (HP:0100712)1.75588879
128Poor head control (HP:0002421)1.74661548
129Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.74279379
130Vertebral compression fractures (HP:0002953)1.73427280
131Akinesia (HP:0002304)1.73328931
132Progressive visual loss (HP:0000529)1.72748397
133Inappropriate behavior (HP:0000719)1.72503441
134Tubulointerstitial nephritis (HP:0001970)1.71929516
135Abnormality of the renal medulla (HP:0100957)1.71599013
136Skin ulcer (HP:0200042)1.70564436
137Gastrointestinal inflammation (HP:0004386)1.70153297
138Absent rod-and cone-mediated responses on ERG (HP:0007688)1.68986169
139Renal salt wasting (HP:0000127)1.66875279
140Anencephaly (HP:0002323)1.66764035
141Short nail (HP:0001799)1.57186750
142Aplasia/Hypoplasia of the tongue (HP:0010295)1.54643703
143Male pseudohermaphroditism (HP:0000037)1.54528646
144Abnormality of the distal phalanges of the toes (HP:0010182)1.54193238
145Glucose intolerance (HP:0000833)1.53443394
146Tubular atrophy (HP:0000092)1.52863870
147Aplasia/Hypoplasia of the spleen (HP:0010451)1.50321643
148Oculomotor apraxia (HP:0000657)1.49675865
149Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.49405047
150Asplenia (HP:0001746)1.47589664
151Furrowed tongue (HP:0000221)1.45448699
152Abnormality of the frontal sinuses (HP:0002687)1.37326803
153Hyperkalemia (HP:0002153)1.37289032
154Abnormality of renin-angiotensin system (HP:0000847)1.32388521
155Hyperaldosteronism (HP:0000859)1.31428046
156Increased serum ferritin (HP:0003281)1.30639357
157Medial flaring of the eyebrow (HP:0010747)1.29171124
158Abnormality of monocarboxylic acid metabolism (HP:0010996)1.28317994
159Abnormality of chloride homeostasis (HP:0011422)1.27338276
160Hand muscle atrophy (HP:0009130)1.25436130
161Short femoral neck (HP:0100864)1.25184066
162Distal lower limb muscle weakness (HP:0009053)1.23001587
163Sclerocornea (HP:0000647)1.21715382
164Cone-rod dystrophy (HP:0000548)1.20272371
165Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.17875823
166Congenital primary aphakia (HP:0007707)1.17623023
167Short thorax (HP:0010306)1.17266558
168Hypokalemic alkalosis (HP:0001949)1.14171557
169Vascular calcification (HP:0004934)1.13055934
170Abnormal glucose tolerance (HP:0001952)1.12145771
171Stridor (HP:0010307)1.12053528
172Decreased central vision (HP:0007663)1.12034297
173Diaphragmatic weakness (HP:0009113)1.11991849
174Flat acetabular roof (HP:0003180)1.11893655
175Stage 5 chronic kidney disease (HP:0003774)1.10848707

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK158.68738771
2EPHA24.39177560
3BLK4.25338259
4RIPK43.63404222
5EPHB13.28736378
6IRAK43.16795158
7MAP4K13.15000828
8MAP3K32.84630119
9PBK2.78069954
10ERN12.77304960
11MST42.62883860
12MAP3K142.61769432
13TBK12.52320015
14FGR2.41865278
15TRIB32.04986234
16CSK1.97577558
17MAPKAPK31.91293181
18IRAK31.84978198
19KIT1.70822214
20TYK21.68612245
21TRPM71.67755905
22SMG11.64357550
23CSF1R1.63019761
24FES1.59584638
25STK101.56463653
26IKBKB1.47559401
27IKBKE1.43207331
28HCK1.41667786
29TGFBR21.38216500
30BTK1.33252784
31ZAP701.32836421
32LRRK21.29876725
33STK391.29470730
34TLK11.27404730
35CLK11.20606808
36ARAF1.18505395
37MARK21.16611201
38MAP3K131.15836758
39KSR21.14817583
40ABL21.13207620
41NME11.13021260
42SYK1.11527238
43TEC1.09857514
44MAP3K71.09210368
45PIM21.08813027
46LYN1.08544097
47RIPK11.07451813
48TAOK11.04816809
49EEF2K1.04355653
50JAK11.01450627
51JAK31.00854134
52MET0.99991085
53MAP2K30.98592612
54LCK0.98338983
55ITK0.96451388
56TESK10.95698619
57NEK90.94351677
58STK240.89995602
59PKN10.89123362
60TXK0.88364052
61TTN0.87160536
62BMX0.87000888
63CDC42BPA0.86414468
64PTK60.84713797
65EGFR0.82836768
66MOS0.78593828
67ICK0.78576701
68PRKD20.78220534
69MST1R0.77080292
70PRKCD0.75408148
71TAOK30.74450582
72GRK60.74392030
73STK380.73936362
74PAK40.73781133
75HIPK20.73482155
76PDPK10.69369223
77FYN0.68939372
78ABL10.67928008
79PRKCQ0.67747432
80JAK20.67726865
81NTRK10.67532017
82NME20.66551483
83MARK30.64665854
84PRKCI0.64665042
85ERBB30.63856108
86MATK0.63504614
87IRAK10.63256665
88TAOK20.62931839
89TNK20.61443503
90ACVR1B0.61253738
91MAP3K10.60131704
92CAMK1D0.59893372
93RPS6KA40.59293790
94MAP3K110.59074136
95STK40.58662637
96BMPR20.58608075
97NEK60.58279486
98ADRBK20.55981375
99PTK2B0.54891882
100RPS6KA20.54559892
101PRKCH0.53769095
102SIK10.52757766
103ADRBK10.52617095
104CAMKK20.52471217
105CAMKK10.51701340
106TESK20.51694532
107DAPK30.51612017
108MAP3K20.51003464
109MAPKAPK20.50967708
110PIK3CG0.50909219
111PRKG20.48976721
112BMPR1B0.48199020
113PDK10.47737316
114LMTK20.45934855
115MAP2K20.45611430
116CHUK0.44360076
117MAP3K60.44095820
118PTK20.43382145
119PRKAA20.42309264
120PDGFRB0.41437351
121MYLK0.39834358
122PIM10.39305853
123GRK70.39143072
124INSR0.39107811
125GSK3A0.38359469
126CAMK1G0.37853853
127PRKD10.36174309
128DYRK1B0.35575027
129ILK0.34235050
130LIMK10.33567535
131KDR0.33334126
132MAP2K10.33320056
133PRPF4B0.33272154
134EPHA30.32654610
135CAMK2G0.31950253
136OXSR10.31923786
137ERBB20.31807642
138RPS6KA60.30175762
139MAPK110.28998358

Predicted pathways (KEGG)

RankGene SetZ-score
1* Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009803.66399137
2Staphylococcus aureus infection_Homo sapiens_hsa051503.64006839
3Leishmaniasis_Homo sapiens_hsa051403.20107088
4Lysosome_Homo sapiens_hsa041423.09891796
5* Chemical carcinogenesis_Homo sapiens_hsa052043.05049736
6Phagosome_Homo sapiens_hsa041452.48040828
7* Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.46902048
8Other glycan degradation_Homo sapiens_hsa005112.45171071
9Osteoclast differentiation_Homo sapiens_hsa043802.39050333
10Steroid biosynthesis_Homo sapiens_hsa001002.28813192
11Malaria_Homo sapiens_hsa051442.25978875
12Tuberculosis_Homo sapiens_hsa051522.23646952
13Pertussis_Homo sapiens_hsa051332.20689398
14Rheumatoid arthritis_Homo sapiens_hsa053232.19628647
15Glycosaminoglycan degradation_Homo sapiens_hsa005312.17332891
16Toll-like receptor signaling pathway_Homo sapiens_hsa046202.04230688
17Legionellosis_Homo sapiens_hsa051342.01249065
18B cell receptor signaling pathway_Homo sapiens_hsa046621.97037521
19NOD-like receptor signaling pathway_Homo sapiens_hsa046211.87246825
20Salmonella infection_Homo sapiens_hsa051321.84953784
21NF-kappa B signaling pathway_Homo sapiens_hsa040641.80959846
22Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.80535829
23Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.64557495
24Leukocyte transendothelial migration_Homo sapiens_hsa046701.58384300
25Graft-versus-host disease_Homo sapiens_hsa053321.54098209
26Shigellosis_Homo sapiens_hsa051311.51657467
27Retinol metabolism_Homo sapiens_hsa008301.50582938
28Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.48632868
29Chemokine signaling pathway_Homo sapiens_hsa040621.45435582
30* Tyrosine metabolism_Homo sapiens_hsa003501.44249237
31Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.38236235
32Asthma_Homo sapiens_hsa053101.38141577
33Hematopoietic cell lineage_Homo sapiens_hsa046401.34989897
34ABC transporters_Homo sapiens_hsa020101.34435411
35Linoleic acid metabolism_Homo sapiens_hsa005911.33165890
36TNF signaling pathway_Homo sapiens_hsa046681.32048871
37Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.26576636
38Toxoplasmosis_Homo sapiens_hsa051451.25685282
39Collecting duct acid secretion_Homo sapiens_hsa049661.24382402
40Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.23533865
41Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.22123830
42Intestinal immune network for IgA production_Homo sapiens_hsa046721.21860116
43RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.19984128
44Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.18558912
45Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.16999080
46Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.14408496
47Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.14330892
48Sphingolipid metabolism_Homo sapiens_hsa006001.12872364
49Apoptosis_Homo sapiens_hsa042101.11912556
50Measles_Homo sapiens_hsa051621.09567605
51Steroid hormone biosynthesis_Homo sapiens_hsa001401.09364387
52Huntingtons disease_Homo sapiens_hsa050161.09083152
53Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.06634639
54Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.05210172
55Ether lipid metabolism_Homo sapiens_hsa005651.05176875
56Complement and coagulation cascades_Homo sapiens_hsa046101.05098488
57Amoebiasis_Homo sapiens_hsa051461.02368217
58Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.01911165
59Mineral absorption_Homo sapiens_hsa049781.01519331
60Drug metabolism - other enzymes_Homo sapiens_hsa009831.00734570
61SNARE interactions in vesicular transport_Homo sapiens_hsa041300.98961212
62Antigen processing and presentation_Homo sapiens_hsa046120.98208295
63Influenza A_Homo sapiens_hsa051640.97872987
64Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.97651577
65Caffeine metabolism_Homo sapiens_hsa002320.93491907
66Allograft rejection_Homo sapiens_hsa053300.93285795
67Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.92683183
68African trypanosomiasis_Homo sapiens_hsa051430.90331688
69Starch and sucrose metabolism_Homo sapiens_hsa005000.83884058
70* Phenylalanine metabolism_Homo sapiens_hsa003600.83419833
71Glycerophospholipid metabolism_Homo sapiens_hsa005640.79860984
72Platelet activation_Homo sapiens_hsa046110.79818729
73Hepatitis C_Homo sapiens_hsa051600.79766668
74Sphingolipid signaling pathway_Homo sapiens_hsa040710.78489814
75Vibrio cholerae infection_Homo sapiens_hsa051100.78068854
76Endocytosis_Homo sapiens_hsa041440.78051064
77AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.77759305
78Jak-STAT signaling pathway_Homo sapiens_hsa046300.76994729
79Cyanoamino acid metabolism_Homo sapiens_hsa004600.76536311
80Renin-angiotensin system_Homo sapiens_hsa046140.73687173
81Viral myocarditis_Homo sapiens_hsa054160.72653495
82Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.72024752
83Fatty acid elongation_Homo sapiens_hsa000620.70329609
84Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.70256850
85Salivary secretion_Homo sapiens_hsa049700.70249410
86Pancreatic cancer_Homo sapiens_hsa052120.68926896
87Hepatitis B_Homo sapiens_hsa051610.68558938
88Notch signaling pathway_Homo sapiens_hsa043300.67764400
89Peroxisome_Homo sapiens_hsa041460.67506943
90Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.67452159
91* Histidine metabolism_Homo sapiens_hsa003400.61301447
92Choline metabolism in cancer_Homo sapiens_hsa052310.60648447
93Regulation of actin cytoskeleton_Homo sapiens_hsa048100.60171721
94Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.58839118
95Fatty acid degradation_Homo sapiens_hsa000710.57508962
96Fructose and mannose metabolism_Homo sapiens_hsa000510.57394879
97Prion diseases_Homo sapiens_hsa050200.54810517
98Insulin resistance_Homo sapiens_hsa049310.53218713
99T cell receptor signaling pathway_Homo sapiens_hsa046600.52346133
100Adipocytokine signaling pathway_Homo sapiens_hsa049200.52084631
101Tight junction_Homo sapiens_hsa045300.51872247
102VEGF signaling pathway_Homo sapiens_hsa043700.51470521
103Renal cell carcinoma_Homo sapiens_hsa052110.48457718
104Transcriptional misregulation in cancer_Homo sapiens_hsa052020.47562542
105Glutathione metabolism_Homo sapiens_hsa004800.47427398
106* beta-Alanine metabolism_Homo sapiens_hsa004100.47231479
107Carbohydrate digestion and absorption_Homo sapiens_hsa049730.47026692
108Primary immunodeficiency_Homo sapiens_hsa053400.46855950
109Herpes simplex infection_Homo sapiens_hsa051680.45587610
110PPAR signaling pathway_Homo sapiens_hsa033200.45331600
111Neurotrophin signaling pathway_Homo sapiens_hsa047220.45006308
112Pentose and glucuronate interconversions_Homo sapiens_hsa000400.44963865
113Sulfur metabolism_Homo sapiens_hsa009200.43635761
114Galactose metabolism_Homo sapiens_hsa000520.42945756
115Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.42361265
116Acute myeloid leukemia_Homo sapiens_hsa052210.41781741
117Chronic myeloid leukemia_Homo sapiens_hsa052200.41473891
118Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.40258058
119Autoimmune thyroid disease_Homo sapiens_hsa053200.40085437
120Arachidonic acid metabolism_Homo sapiens_hsa005900.40082307
121Regulation of autophagy_Homo sapiens_hsa041400.39564580
122Type I diabetes mellitus_Homo sapiens_hsa049400.39140482
123Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.38956554
124Dorso-ventral axis formation_Homo sapiens_hsa043200.38947599
125Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.36918130
126Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.36607776
127Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.32555183
128Proteoglycans in cancer_Homo sapiens_hsa052050.32345008
129Focal adhesion_Homo sapiens_hsa045100.31178775
130Pentose phosphate pathway_Homo sapiens_hsa000300.30537251
131Phospholipase D signaling pathway_Homo sapiens_hsa040720.29110480
132Vitamin digestion and absorption_Homo sapiens_hsa049770.27569916
133Viral carcinogenesis_Homo sapiens_hsa052030.26214614
134Protein export_Homo sapiens_hsa030600.24667494

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