ALDH1B1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This protein belongs to the aldehyde dehydrogenases family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. This gene does not contain introns in the coding sequence. The variation of this locus may affect the development of alcohol-related problems. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.54637229
2L-phenylalanine catabolic process (GO:0006559)6.54637229
3triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.50077209
4L-phenylalanine metabolic process (GO:0006558)6.42758939
5erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.42758939
6urea metabolic process (GO:0019627)5.98910042
7urea cycle (GO:0000050)5.98910042
8aromatic amino acid family catabolic process (GO:0009074)5.79843301
9nitrogen cycle metabolic process (GO:0071941)5.45366930
10high-density lipoprotein particle remodeling (GO:0034375)5.44131566
11kynurenine metabolic process (GO:0070189)5.34839177
12glyoxylate metabolic process (GO:0046487)5.20395696
13sulfur amino acid catabolic process (GO:0000098)5.16687758
14indole-containing compound catabolic process (GO:0042436)5.16635610
15indolalkylamine catabolic process (GO:0046218)5.16635610
16tryptophan catabolic process (GO:0006569)5.16635610
17alpha-linolenic acid metabolic process (GO:0036109)5.12606019
18regulation of cholesterol esterification (GO:0010872)5.10109585
19regulation of triglyceride catabolic process (GO:0010896)5.04493404
20negative regulation of fibrinolysis (GO:0051918)5.01920888
21bile acid biosynthetic process (GO:0006699)4.98217980
22phospholipid efflux (GO:0033700)4.96011665
23homocysteine metabolic process (GO:0050667)4.93855465
24reverse cholesterol transport (GO:0043691)4.93825664
25acylglycerol homeostasis (GO:0055090)4.91870124
26triglyceride homeostasis (GO:0070328)4.91870124
27tryptophan metabolic process (GO:0006568)4.87260042
28macromolecular complex remodeling (GO:0034367)4.85991277
29plasma lipoprotein particle remodeling (GO:0034369)4.85991277
30protein-lipid complex remodeling (GO:0034368)4.85991277
31cysteine metabolic process (GO:0006534)4.82936609
32negative regulation of sterol transport (GO:0032372)4.79101427
33negative regulation of cholesterol transport (GO:0032375)4.79101427
34intestinal cholesterol absorption (GO:0030299)4.77887308
35drug catabolic process (GO:0042737)4.76043518
36regulation of fibrinolysis (GO:0051917)4.70097728
37L-serine metabolic process (GO:0006563)4.69004337
38bile acid metabolic process (GO:0008206)4.61040272
39bile acid and bile salt transport (GO:0015721)4.60638034
40serine family amino acid catabolic process (GO:0009071)4.56945009
41peptidyl-glutamic acid carboxylation (GO:0017187)4.55550683
42protein carboxylation (GO:0018214)4.55550683
43plasma lipoprotein particle assembly (GO:0034377)4.51621332
44regulation of protein activation cascade (GO:2000257)4.51108009
45cellular ketone body metabolic process (GO:0046950)4.47568263
46lysine catabolic process (GO:0006554)4.46053149
47lysine metabolic process (GO:0006553)4.46053149
48amino-acid betaine metabolic process (GO:0006577)4.44146141
49cholesterol efflux (GO:0033344)4.42565372
50intestinal absorption (GO:0050892)4.41913023
51fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.40325093
52plasma lipoprotein particle clearance (GO:0034381)4.37422353
53flavonoid metabolic process (GO:0009812)4.34442932
54complement activation, alternative pathway (GO:0006957)4.33141677
55aromatic amino acid family metabolic process (GO:0009072)4.25058832
56phospholipid homeostasis (GO:0055091)4.23106533
57regulation of bile acid biosynthetic process (GO:0070857)4.16793909
58cellular glucuronidation (GO:0052695)4.15065019
59very-low-density lipoprotein particle assembly (GO:0034379)4.14528658
60regulation of complement activation (GO:0030449)4.14405649
61glycine metabolic process (GO:0006544)4.14208844
62alpha-amino acid catabolic process (GO:1901606)4.12919936
63cholesterol homeostasis (GO:0042632)4.07988463
64protein-lipid complex assembly (GO:0065005)4.06946779
65positive regulation of triglyceride lipase activity (GO:0061365)4.06512605
66positive regulation of lipoprotein lipase activity (GO:0051006)4.06512605
67regulation of cholesterol homeostasis (GO:2000188)4.02507193
68sterol homeostasis (GO:0055092)4.01512508
69lipoprotein metabolic process (GO:0042157)3.98152594
70glutamate metabolic process (GO:0006536)3.97150984
71arginine metabolic process (GO:0006525)3.95616708
72serine family amino acid biosynthetic process (GO:0009070)3.92740349
73tyrosine metabolic process (GO:0006570)3.90609686
74low-density lipoprotein particle remodeling (GO:0034374)3.90037466
75cellular amino acid catabolic process (GO:0009063)3.86581525
76ethanol oxidation (GO:0006069)3.85545206
77serine family amino acid metabolic process (GO:0009069)3.85364094
78ketone body metabolic process (GO:1902224)3.84378570
79plasma lipoprotein particle organization (GO:0071827)3.83519495
80positive regulation of lipid catabolic process (GO:0050996)3.80204688
81benzene-containing compound metabolic process (GO:0042537)3.76155979
82cellular modified amino acid catabolic process (GO:0042219)3.75372115
83glucuronate metabolic process (GO:0019585)3.73609206
84uronic acid metabolic process (GO:0006063)3.73609206
85imidazole-containing compound metabolic process (GO:0052803)3.71966652
86short-chain fatty acid metabolic process (GO:0046459)3.70578699
87dicarboxylic acid biosynthetic process (GO:0043650)3.67910793
88indolalkylamine metabolic process (GO:0006586)3.65597806
89protein-lipid complex subunit organization (GO:0071825)3.61973099
90aldehyde catabolic process (GO:0046185)3.60602970
91drug metabolic process (GO:0017144)3.54699850
92proline metabolic process (GO:0006560)3.53359946
93plasma membrane repair (GO:0001778)3.53233821
94glutamine family amino acid biosynthetic process (GO:0009084)3.52589879
95exogenous drug catabolic process (GO:0042738)3.48636658
96amine catabolic process (GO:0009310)3.45735834
97cellular biogenic amine catabolic process (GO:0042402)3.45735834
98killing of cells of other organism (GO:0031640)3.45263912
99disruption of cells of other organism (GO:0044364)3.45263912
100organic acid catabolic process (GO:0016054)3.45053953
101carboxylic acid catabolic process (GO:0046395)3.45053953
102response to nitrosative stress (GO:0051409)3.44518274
103aspartate family amino acid catabolic process (GO:0009068)3.41541262
104regulation of plasminogen activation (GO:0010755)3.39451687
105proline biosynthetic process (GO:0006561)3.39199853
106NADH metabolic process (GO:0006734)3.22423646
107epoxygenase P450 pathway (GO:0019373)3.11764677
108blood coagulation, intrinsic pathway (GO:0007597)3.09670968
109fibrinolysis (GO:0042730)3.02692575
110tetrahydrofolate metabolic process (GO:0046653)3.02678146
111oxidative demethylation (GO:0070989)2.92672203
112omega-hydroxylase P450 pathway (GO:0097267)2.90158532
113establishment of integrated proviral latency (GO:0075713)2.89271540
114regulation of translational fidelity (GO:0006450)2.80977224
115regulation of sarcomere organization (GO:0060297)2.79688522
116negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.77668219
117DNA strand elongation involved in DNA replication (GO:0006271)2.77202974
118polyketide metabolic process (GO:0030638)2.74375123
119doxorubicin metabolic process (GO:0044598)2.74375123
120daunorubicin metabolic process (GO:0044597)2.74375123
121ribosome assembly (GO:0042255)2.68044905
122negative regulation of protein localization to cell surface (GO:2000009)2.64240258
123DNA strand elongation (GO:0022616)2.63629101
124response to muscle activity (GO:0014850)2.63057676
125IMP biosynthetic process (GO:0006188)2.62381101
126tricarboxylic acid cycle (GO:0006099)2.57294718
127branched-chain amino acid catabolic process (GO:0009083)2.53500845
128water-soluble vitamin biosynthetic process (GO:0042364)2.52330749
129folic acid-containing compound metabolic process (GO:0006760)2.51848404
130negative regulation of heart growth (GO:0061117)2.49196910
131negative regulation of cardiac muscle tissue growth (GO:0055022)2.49196910
132biotin metabolic process (GO:0006768)2.48706906
133ribonucleoprotein complex disassembly (GO:0032988)2.48167016
134pteridine-containing compound metabolic process (GO:0042558)2.46106116
135alpha-amino acid biosynthetic process (GO:1901607)2.45018944
136negative regulation of potassium ion transmembrane transport (GO:1901380)2.44510800
137aminoglycoside antibiotic metabolic process (GO:0030647)2.44450008
138IMP metabolic process (GO:0046040)2.44202857
139mitotic metaphase plate congression (GO:0007080)2.41524986
140oxaloacetate metabolic process (GO:0006107)2.40430858
141nucleobase biosynthetic process (GO:0046112)2.39278352
142nucleotide-sugar biosynthetic process (GO:0009226)2.39212675
143telomere maintenance via semi-conservative replication (GO:0032201)2.38748335
144DNA unwinding involved in DNA replication (GO:0006268)2.38719477
145pteridine-containing compound biosynthetic process (GO:0042559)2.38525818
146protein localization to kinetochore (GO:0034501)2.38293135
147regulation of skeletal muscle contraction (GO:0014819)2.35244932
148DNA replication-dependent nucleosome assembly (GO:0006335)2.34792984
149DNA replication-dependent nucleosome organization (GO:0034723)2.34792984
150phenylpropanoid metabolic process (GO:0009698)2.32926529
151glutamine family amino acid metabolic process (GO:0009064)2.32528678
152nucleobase-containing small molecule interconversion (GO:0015949)2.31971289
153folic acid-containing compound biosynthetic process (GO:0009396)2.30058057
1544-hydroxyproline metabolic process (GO:0019471)2.29408485
155chromatin remodeling at centromere (GO:0031055)2.28235543
156tRNA aminoacylation for protein translation (GO:0006418)2.27760595

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse7.65735453
2PPARA_22158963_ChIP-Seq_LIVER_Mouse7.00025560
3E2F7_22180533_ChIP-Seq_HELA_Human6.26897188
4LXR_22158963_ChIP-Seq_LIVER_Mouse6.05007389
5EGR1_23403033_ChIP-Seq_LIVER_Mouse5.96093518
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.39367615
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.61215469
8FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.54268156
9MYC_18555785_ChIP-Seq_MESCs_Mouse3.90029504
10NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.74774694
11CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.38450855
12KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.35568895
13FOXM1_23109430_ChIP-Seq_U2OS_Human3.04423988
14FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.94950857
15HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.87531916
16E2F4_17652178_ChIP-ChIP_JURKAT_Human2.76069507
17MYC_19030024_ChIP-ChIP_MESCs_Mouse2.64947979
18MYC_18358816_ChIP-ChIP_MESCs_Mouse2.55769131
19HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.50378313
20E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.43007462
21JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.37815189
22MYC_19079543_ChIP-ChIP_MESCs_Mouse2.34801338
23CREB1_15753290_ChIP-ChIP_HEK293T_Human2.24831485
24GABP_17652178_ChIP-ChIP_JURKAT_Human2.13928924
25E2F1_18555785_ChIP-Seq_MESCs_Mouse2.12862472
26TP63_17297297_ChIP-ChIP_HaCaT_Human2.12538037
27NELFA_20434984_ChIP-Seq_ESCs_Mouse2.09974507
28CDX2_20551321_ChIP-Seq_CACO-2_Human2.08601635
29EST1_17652178_ChIP-ChIP_JURKAT_Human2.08180170
30TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.04268791
31ETS1_20019798_ChIP-Seq_JURKAT_Human2.01330488
32ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.1796780
33SOX2_27498859_Chip-Seq_STOMACH_Mouse1.93002213
34CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.91011146
35RBPJ_22232070_ChIP-Seq_NCS_Mouse1.89521169
36TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.88235604
37NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.84869472
38E2F1_21310950_ChIP-Seq_MCF-7_Human1.82946794
39THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.80961629
40ZFX_18555785_ChIP-Seq_MESCs_Mouse1.80223783
41MYCN_18555785_ChIP-Seq_MESCs_Mouse1.77632221
42TRIM28_21343339_ChIP-Seq_HEK293_Human1.75781647
43GATA1_22025678_ChIP-Seq_K562_Human1.70890162
44MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.70633231
45CLOCK_20551151_ChIP-Seq_293T_Human1.70347623
46THAP11_20581084_ChIP-Seq_MESCs_Mouse1.69805025
47GATA4_25053715_ChIP-Seq_YYC3_Human1.67285820
48KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.65721452
49PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.63813925
50FOXA2_19822575_ChIP-Seq_HepG2_Human1.61193451
51XRN2_22483619_ChIP-Seq_HELA_Human1.58252747
52MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.56040031
53* HNF4A_19822575_ChIP-Seq_HepG2_Human1.55571868
54TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.55490840
55ELK1_19687146_ChIP-ChIP_HELA_Human1.55387519
56SRF_21415370_ChIP-Seq_HL-1_Mouse1.51567668
57STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.50081852
58NANOG_18555785_ChIP-Seq_MESCs_Mouse1.49488606
59DCP1A_22483619_ChIP-Seq_HELA_Human1.44312228
60TTF2_22483619_ChIP-Seq_HELA_Human1.43593979
61GABP_19822575_ChIP-Seq_HepG2_Human1.43105410
62ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.42680374
63STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.38722364
64IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.38306551
65POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.38023427
66GATA6_25053715_ChIP-Seq_YYC3_Human1.38010594
67YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.36576243
68ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.33744758
69HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.31327377
70ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.30092653
71PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.26221638
72NANOG_16153702_ChIP-ChIP_HESCs_Human1.25741109
73* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.23846706
74PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.23750847
75ESR1_15608294_ChIP-ChIP_MCF-7_Human1.23113450
76SOX17_20123909_ChIP-Seq_XEN_Mouse1.22683475
77POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.21935126
78ZNF263_19887448_ChIP-Seq_K562_Human1.20493660
79SOX2_18555785_ChIP-Seq_MESCs_Mouse1.19591771
80IRF8_22096565_ChIP-ChIP_GC-B_Human1.18335355
81FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.17986074
82FOXP3_21729870_ChIP-Seq_TREG_Human1.15761192
83TCF3_18692474_ChIP-Seq_MEFs_Mouse1.14872944
84CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.14566863
85FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.14275381
86SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.13323318
87RXRA_24833708_ChIP-Seq_LIVER_Mouse1.07121138
88HTT_18923047_ChIP-ChIP_STHdh_Human1.07102603
89CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.04690483
90SRY_22984422_ChIP-ChIP_TESTIS_Rat1.03392839
91ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.02944257
92KLF4_18555785_ChIP-Seq_MESCs_Mouse1.02561348
93HIF1A_21447827_ChIP-Seq_MCF-7_Human1.02026167
94MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.00007798
95* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.99722932
96* NANOG_21062744_ChIP-ChIP_HESCs_Human0.99048276
97SOX2_20726797_ChIP-Seq_SW620_Human0.96982419
98RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.96828731
99DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.96209794
100PADI4_21655091_ChIP-ChIP_MCF-7_Human0.95870435
101ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.95733632
102SOX2_18692474_ChIP-Seq_MEFs_Mouse0.94174599
103BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.94050220
104MYC_18940864_ChIP-ChIP_HL60_Human0.93149796
105KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.91547709
106KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.91547709
107KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.91547709
108RARG_19884340_ChIP-ChIP_MEFs_Mouse0.91078809
109PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.90814322
110NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.90708856
111DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.90468701
112HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.89963731
113SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.89578951
114* LXR_22292898_ChIP-Seq_THP-1_Human0.88926621
115NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.88557001
116NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.88479814
117RARA_24833708_ChIP-Seq_LIVER_Mouse0.88407099
118* TBX5_21415370_ChIP-Seq_HL-1_Mouse0.86851443
119SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.86282509
120YY1_21170310_ChIP-Seq_MESCs_Mouse0.84767401
121STAT3_1855785_ChIP-Seq_MESCs_Mouse0.84736347
122NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.84364710
123MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.82725642
124AR_21909140_ChIP-Seq_LNCAP_Human0.78554926
125RACK7_27058665_Chip-Seq_MCF-7_Human0.77736879
126EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.75576835
127PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.75253228
128KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.73008114
129BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.72959458
130ESR2_21235772_ChIP-Seq_MCF-7_Human0.72707183
131AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.71188619
132SALL4_18804426_ChIP-ChIP_XEN_Mouse0.70023601
133PPAR_26484153_Chip-Seq_NCI-H1993_Human0.69442324
134FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.69394388
135PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.67183806
136RARB_24833708_ChIP-Seq_LIVER_Mouse0.66890493
137FOXO3_23340844_ChIP-Seq_DLD1_Human0.66885032
138ESR1_20079471_ChIP-ChIP_T-47D_Human0.66338701
139KAP1_22055183_ChIP-Seq_ESCs_Mouse0.65486600
140GATA2_19941826_ChIP-Seq_K562_Human0.64959848
141ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.64893574
142AUTS2_25519132_ChIP-Seq_293T-REX_Human0.64623142
143SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.64407070
144ATF3_27146783_Chip-Seq_COLON_Human0.63564282
145PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.61915540
146PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.61375497
147EGR1_19032775_ChIP-ChIP_M12_Human0.60468802
148BCOR_27268052_Chip-Seq_Bcells_Human0.60427654
149RAD21_21589869_ChIP-Seq_MESCs_Mouse0.59668676
150FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.59620108
151CEBPB_22108803_ChIP-Seq_LS180_Human0.59136234
152GATA1_19941826_ChIP-Seq_K562_Human0.58573355
153BCL6_27268052_Chip-Seq_Bcells_Human0.57322932
154OCT4_18692474_ChIP-Seq_MEFs_Mouse0.57261089
155CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.56840914
156CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.56305575
157FOXA1_25552417_ChIP-Seq_VCAP_Human0.56285764
158POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.56034993
159NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.55006937
160KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.54916067
161MYC_19915707_ChIP-ChIP_AK7_Human0.54139490
162CREB1_26743006_Chip-Seq_LNCaP_Human0.52656554
163NANOG_20526341_ChIP-Seq_ESCs_Human0.52112737
164SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.51979538
165SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.51860883
166* GATA1_19941827_ChIP-Seq_MEL_Mouse0.50490925
167BRD4_27068464_Chip-Seq_AML-cells_Mouse0.50482794
168GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.50378052
169ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.48304423
170GATA1_22383799_ChIP-Seq_G1ME_Mouse0.48182933
171* PHF8_20622854_ChIP-Seq_HELA_Human0.47634700
172AR_20517297_ChIP-Seq_VCAP_Human0.47063674
173P300_27268052_Chip-Seq_Bcells_Human0.46701122
174GATA2_22383799_ChIP-Seq_G1ME_Mouse0.46115751
175TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.45872169

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis8.16605117
2MP0002139_abnormal_hepatobiliary_system7.51673374
3MP0005085_abnormal_gallbladder_physiolo6.13833372
4MP0005365_abnormal_bile_salt5.69512664
5MP0008875_abnormal_xenobiotic_pharmacok4.62328015
6MP0003806_abnormal_nucleotide_metabolis4.19806428
7MP0003252_abnormal_bile_duct3.69817856
8MP0001666_abnormal_nutrient_absorption3.55306899
9MP0010329_abnormal_lipoprotein_level3.54208120
10MP0009840_abnormal_foam_cell3.47068854
11MP0003950_abnormal_plasma_membrane3.17721160
12MP0005083_abnormal_biliary_tract2.89852426
13MP0003941_abnormal_skin_development2.71719046
14MP0005332_abnormal_amino_acid2.55796876
15MP0003191_abnormal_cellular_cholesterol2.32770775
16MP0003693_abnormal_embryo_hatching2.32215185
17MP0000749_muscle_degeneration2.17090763
18MP0008438_abnormal_cutaneous_collagen2.17010974
19MP0004019_abnormal_vitamin_homeostasis2.14886785
20MP0010030_abnormal_orbit_morphology2.07556446
21MP0004272_abnormal_basement_membrane2.06400198
22MP0010094_abnormal_chromosome_stability2.03910487
23MP0000609_abnormal_liver_physiology2.03634215
24MP0000751_myopathy2.00969167
25MP0003111_abnormal_nucleus_morphology1.98993692
26MP0004957_abnormal_blastocyst_morpholog1.92225149
27MP0003195_calcinosis1.91780932
28MP0002118_abnormal_lipid_homeostasis1.88190507
29MP0003868_abnormal_feces_composition1.81609758
30MP0005319_abnormal_enzyme/_coenzyme1.77398073
31MP0008058_abnormal_DNA_repair1.73654194
32MP0002138_abnormal_hepatobiliary_system1.68928981
33MP0004264_abnormal_extraembryonic_tissu1.56238989
34MP0001764_abnormal_homeostasis1.54840871
35MP0009697_abnormal_copulation1.50645959
36MP0008932_abnormal_embryonic_tissue1.48050498
37MP0006292_abnormal_olfactory_placode1.47415489
38MP0005584_abnormal_enzyme/coenzyme_acti1.43568856
39MP0003705_abnormal_hypodermis_morpholog1.42496729
40MP0009643_abnormal_urine_homeostasis1.42142435
41MP0005451_abnormal_body_composition1.38231795
42MP0004145_abnormal_muscle_electrophysio1.37817402
43MP0002269_muscular_atrophy1.29733334
44MP0001293_anophthalmia1.29608268
45MP0003077_abnormal_cell_cycle1.28880299
46MP0010234_abnormal_vibrissa_follicle1.28547163
47MP0002938_white_spotting1.27563844
48MP0005623_abnormal_meninges_morphology1.20339356
49MP0001873_stomach_inflammation1.14473586
50MP0002697_abnormal_eye_size1.11951566
51MP0002822_catalepsy1.11446018
52MP0001730_embryonic_growth_arrest1.11407881
53MP0005084_abnormal_gallbladder_morpholo1.11402088
54MP0000598_abnormal_liver_morphology1.11278526
55MP0004233_abnormal_muscle_weight1.10582491
56MP0003937_abnormal_limbs/digits/tail_de1.06928475
57MP0003566_abnormal_cell_adhesion1.03910282
58MP0008007_abnormal_cellular_replicative1.02585853
59MP0003656_abnormal_erythrocyte_physiolo1.02156963
60MP0003567_abnormal_fetal_cardiomyocyte1.01450044
61MP0001915_intracranial_hemorrhage0.99312337
62MP0006036_abnormal_mitochondrial_physio0.98745765
63MP0005257_abnormal_intraocular_pressure0.98217986
64MP0001663_abnormal_digestive_system0.96795097
65MP0003123_paternal_imprinting0.96363683
66MP0000604_amyloidosis0.96233888
67MP0004087_abnormal_muscle_fiber0.96186132
68MP0005636_abnormal_mineral_homeostasis0.95973797
69MP0000462_abnormal_digestive_system0.95397635
70MP0002254_reproductive_system_inflammat0.95250930
71MP0010155_abnormal_intestine_physiology0.94943671
72MP0003186_abnormal_redox_activity0.94476580
73MP0005395_other_phenotype0.93953971
74MP0003300_gastrointestinal_ulcer0.92963456
75MP0002102_abnormal_ear_morphology0.90491681
76MP0008469_abnormal_protein_level0.89275971
77MP0000566_synostosis0.89275488
78MP0002089_abnormal_postnatal_growth/wei0.88826050
79MP0009763_increased_sensitivity_to0.88008981
80MP0009642_abnormal_blood_homeostasis0.87536167
81MP0000467_abnormal_esophagus_morphology0.87525571
82MP0002233_abnormal_nose_morphology0.86098266
83MP0003315_abnormal_perineum_morphology0.85183356
84MP0003011_delayed_dark_adaptation0.83007624
85MP0002106_abnormal_muscle_physiology0.82859183
86MP0009780_abnormal_chondrocyte_physiolo0.82604784
87MP0000762_abnormal_tongue_morphology0.82311504
88MP0002108_abnormal_muscle_morphology0.81172618
89MP0000759_abnormal_skeletal_muscle0.80770499
90MP0005381_digestive/alimentary_phenotyp0.80759014
91MP0002085_abnormal_embryonic_tissue0.80183608
92MP0003385_abnormal_body_wall0.79386074
93MP0005369_muscle_phenotype0.78397367
94MP0000750_abnormal_muscle_regeneration0.78254515
95MP0002092_abnormal_eye_morphology0.78047869
96MP0009764_decreased_sensitivity_to0.77983939
97MP0002282_abnormal_trachea_morphology0.77803500
98MP0005220_abnormal_exocrine_pancreas0.77626119
99MP0001299_abnormal_eye_distance/0.77470101
100MP0005376_homeostasis/metabolism_phenot0.76862368
101MP0002163_abnormal_gland_morphology0.76330995
102MP0005408_hypopigmentation0.76206916
103MP0001697_abnormal_embryo_size0.76149558
104MP0001286_abnormal_eye_development0.76077969
105MP0005448_abnormal_energy_balance0.74713291
106MP0000350_abnormal_cell_proliferation0.74524642
107MP0002249_abnormal_larynx_morphology0.73552556
108MP0005266_abnormal_metabolism0.73535156
109MP0003942_abnormal_urinary_system0.73275410
110MP0000747_muscle_weakness0.73256300
111MP0000049_abnormal_middle_ear0.73026932
112MP0002078_abnormal_glucose_homeostasis0.72875440
113MP0002084_abnormal_developmental_patter0.72449274
114MP0002234_abnormal_pharynx_morphology0.71838295
115MP0009250_abnormal_appendicular_skeleto0.71399735
116MP0009765_abnormal_xenobiotic_induced0.71167607
117MP0002080_prenatal_lethality0.70905936
118MP0003119_abnormal_digestive_system0.70789404
119MP0005197_abnormal_uvea_morphology0.70453966
120MP0001672_abnormal_embryogenesis/_devel0.69467600
121MP0003866_abnormal_defecation0.67765396
122MP0009053_abnormal_anal_canal0.67425389
123MP0002837_dystrophic_cardiac_calcinosis0.65618584
124MP0000477_abnormal_intestine_morphology0.64389901
125MP0006035_abnormal_mitochondrial_morpho0.64202772
126MP0005647_abnormal_sex_gland0.61317157
127MP0008872_abnormal_physiological_respon0.61213277
128MP0008004_abnormal_stomach_pH0.60670942
129MP0001756_abnormal_urination0.60176882
130MP0010368_abnormal_lymphatic_system0.58480233
131MP0002971_abnormal_brown_adipose0.54479676
132MP0002136_abnormal_kidney_physiology0.53532732
133MP0004130_abnormal_muscle_cell0.52692628
134MP0005166_decreased_susceptibility_to0.51577057
135MP0005334_abnormal_fat_pad0.51490943
136MP0005464_abnormal_platelet_physiology0.50311503
137MP0005167_abnormal_blood-brain_barrier0.50153711
138MP0002796_impaired_skin_barrier0.49948116
139MP0003329_amyloid_beta_deposits0.49460090
140MP0004782_abnormal_surfactant_physiolog0.48815331
141MP0000490_abnormal_crypts_of0.48165898
142MP0010352_gastrointestinal_tract_polyps0.48067954
143MP0008873_increased_physiological_sensi0.47696617
144MP0001845_abnormal_inflammatory_respons0.45622282
145MP0003718_maternal_effect0.44580419
146MP0002876_abnormal_thyroid_physiology0.43698445
147MP0005330_cardiomyopathy0.42939591
148MP0003953_abnormal_hormone_level0.41552243
149MP0005535_abnormal_body_temperature0.41411521
150MP0003638_abnormal_response/metabolism_0.40002091
151MP0000538_abnormal_urinary_bladder0.39977387
152MP0009379_abnormal_foot_pigmentation0.39640906
153MP0009384_cardiac_valve_regurgitation0.38435247
154MP0003724_increased_susceptibility_to0.37974448
155MP0000639_abnormal_adrenal_gland0.37934903
156MP0000537_abnormal_urethra_morphology0.37756294
157MP0001664_abnormal_digestion0.36003194
158MP0009672_abnormal_birth_weight0.35961170
159MP0004147_increased_porphyrin_level0.35460033
160MP0001661_extended_life_span0.35274744
161MP0003436_decreased_susceptibility_to0.34505860
162MP0004947_skin_inflammation0.33231697
163MP0000249_abnormal_blood_vessel0.32891986
164MP0001765_abnormal_ion_homeostasis0.31730546
165MP0005187_abnormal_penis_morphology0.31290600

Predicted human phenotypes

RankGene SetZ-score
1Hypobetalipoproteinemia (HP:0003563)6.70706986
2Intrahepatic cholestasis (HP:0001406)6.59384420
3Deep venous thrombosis (HP:0002625)6.43722690
4Abnormality of aromatic amino acid family metabolism (HP:0004338)6.27102393
5Abnormality of monocarboxylic acid metabolism (HP:0010996)6.17901315
6Xanthomatosis (HP:0000991)5.62413168
7Prolonged partial thromboplastin time (HP:0003645)5.34474457
8Abnormality of glutamine family amino acid metabolism (HP:0010902)4.85453949
9Hyperammonemia (HP:0001987)4.85132946
10Hypolipoproteinemia (HP:0010981)4.71399115
11Ketosis (HP:0001946)4.20462062
12Fat malabsorption (HP:0002630)4.20362575
13Hyperlipoproteinemia (HP:0010980)4.15605295
14Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.13783402
15Increased serum pyruvate (HP:0003542)4.13401281
16Exercise-induced muscle cramps (HP:0003710)4.12356717
17Conjugated hyperbilirubinemia (HP:0002908)4.11608025
18Abnormality of glycolysis (HP:0004366)4.10919722
19Hypoglycemic coma (HP:0001325)4.09690172
20Complement deficiency (HP:0004431)4.00251884
21Epidermoid cyst (HP:0200040)3.96950529
22Abnormality of sulfur amino acid metabolism (HP:0004339)3.92952198
23Joint hemorrhage (HP:0005261)3.89411158
24Exercise-induced myalgia (HP:0003738)3.84743193
25Hyperglycinuria (HP:0003108)3.83939393
26Abnormality of the common coagulation pathway (HP:0010990)3.82222813
27Abnormality of aspartate family amino acid metabolism (HP:0010899)3.81743025
28Hyperglycinemia (HP:0002154)3.76920771
29Abnormality of serine family amino acid metabolism (HP:0010894)3.71272970
30Abnormality of glycine metabolism (HP:0010895)3.71272970
31Calf muscle hypertrophy (HP:0008981)3.65787385
32Ketoacidosis (HP:0001993)3.65250121
33Hypercholesterolemia (HP:0003124)3.61021463
34Hypoalphalipoproteinemia (HP:0003233)3.57055983
35Acanthocytosis (HP:0001927)3.49720795
36Abnormality of methionine metabolism (HP:0010901)3.48417944
37Abnormality of pyrimidine metabolism (HP:0004353)3.43791623
38Muscle hypertrophy of the lower extremities (HP:0008968)3.35768479
39Hyperbilirubinemia (HP:0002904)3.32732998
40Abnormality of fatty-acid metabolism (HP:0004359)3.26901874
41Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.25259609
42Late onset (HP:0003584)3.20739750
43Nemaline bodies (HP:0003798)3.15183126
44Abnormality of the intrinsic pathway (HP:0010989)3.12877099
45Ileus (HP:0002595)3.07662753
46Abnormality of complement system (HP:0005339)3.00468027
47Malnutrition (HP:0004395)2.92878436
48Premature rupture of membranes (HP:0001788)2.90147845
49Dicarboxylic aciduria (HP:0003215)2.88957347
50Abnormality of dicarboxylic acid metabolism (HP:0010995)2.88957347
51Abnormality of nucleobase metabolism (HP:0010932)2.87199002
52Metabolic acidosis (HP:0001942)2.86397557
53Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.85440807
54Muscle fiber inclusion bodies (HP:0100299)2.81307127
55Muscle stiffness (HP:0003552)2.80685580
56Lethargy (HP:0001254)2.75782015
57Hepatocellular carcinoma (HP:0001402)2.73261757
58Cerebral edema (HP:0002181)2.69596721
59Round ear (HP:0100830)2.66901426
60Abnormality of serum amino acid levels (HP:0003112)2.61883975
61Steatorrhea (HP:0002570)2.60229429
62Abnormality of purine metabolism (HP:0004352)2.58902692
63Spontaneous abortion (HP:0005268)2.54788296
64Hypoglycemic seizures (HP:0002173)2.51728812
65Delayed CNS myelination (HP:0002188)2.50828825
66Esophageal varix (HP:0002040)2.50643494
67Right ventricular cardiomyopathy (HP:0011663)2.49447927
68Skin nodule (HP:0200036)2.49015240
69Poikilocytosis (HP:0004447)2.46354844
70Protrusio acetabuli (HP:0003179)2.44504412
71Spastic diplegia (HP:0001264)2.31572254
72Cholecystitis (HP:0001082)2.30665809
73Abnormal gallbladder physiology (HP:0012438)2.30665809
74Myocardial infarction (HP:0001658)2.30290203
75Reduced antithrombin III activity (HP:0001976)2.29362587
76Cholelithiasis (HP:0001081)2.27584492
77Abnormal gallbladder morphology (HP:0012437)2.27349234
78Abnormality of urine glucose concentration (HP:0011016)2.24094462
79Glycosuria (HP:0003076)2.24094462
80Vascular calcification (HP:0004934)2.23150048
81Irritability (HP:0000737)2.20547356
82Abnormality of proline metabolism (HP:0010907)2.20375310
83Hydroxyprolinuria (HP:0003080)2.20375310
84Myotonia (HP:0002486)2.19987749
85Pterygium (HP:0001059)2.18490895
86Vomiting (HP:0002013)2.17702043
87Type 1 muscle fiber predominance (HP:0003803)2.17235369
88Pancreatitis (HP:0001733)2.15206013
89Glomerulonephritis (HP:0000099)2.14914314
90Symptomatic seizures (HP:0011145)2.14884253
91Abnormality of vitamin metabolism (HP:0100508)2.13168606
92Hypochromic microcytic anemia (HP:0004840)2.12679391
93Popliteal pterygium (HP:0009756)2.12215574
94Nausea (HP:0002018)2.11811897
95Systemic lupus erythematosus (HP:0002725)2.10597719
96Neonatal onset (HP:0003623)2.10235931
97Abnormality of the calf musculature (HP:0001430)2.07085056
98Hyperinsulinemic hypoglycemia (HP:0000825)2.07032268
99Abnormal cartilage morphology (HP:0002763)2.06392808
100Amyloidosis (HP:0011034)2.06268907
101Subaortic stenosis (HP:0001682)2.05612307
102Abnormality of the left ventricular outflow tract (HP:0011103)2.05612307
103Gingival bleeding (HP:0000225)2.03563889
104Proximal tubulopathy (HP:0000114)2.01855638
105Abnormality of endocrine pancreas physiology (HP:0012093)2.00038132
106Abnormality of the pancreatic islet cells (HP:0006476)2.00038132
107Gout (HP:0001997)1.99008321
108Generalized aminoaciduria (HP:0002909)1.97830835
109Cardiovascular calcification (HP:0011915)1.96397273
110Abnormality of the gallbladder (HP:0005264)1.90282153
111Palpitations (HP:0001962)1.89851941
112Ragged-red muscle fibers (HP:0003200)1.89518576
113Abnormality of transition element cation homeostasis (HP:0011030)1.88923369
114Sensorimotor neuropathy (HP:0007141)1.88656126
115Alkalosis (HP:0001948)1.88503086
116Reticulocytosis (HP:0001923)1.87204339
117Hepatic necrosis (HP:0002605)1.86985316
118Mitral stenosis (HP:0001718)1.85256848
119Thrombophlebitis (HP:0004418)1.84661954
120Ventricular fibrillation (HP:0001663)1.83098758
121Neck muscle weakness (HP:0000467)1.81847246
122Opisthotonus (HP:0002179)1.81594296
123Abnormality of placental membranes (HP:0011409)1.81308273
124Amniotic constriction ring (HP:0009775)1.81308273
125Hypoplasia of the capital femoral epiphysis (HP:0003090)1.78484984
126Chromosomal breakage induced by crosslinking agents (HP:0003221)1.75355334
127Abnormal delivery (HP:0001787)1.74172901
128Gowers sign (HP:0003391)1.69231095
129Poor suck (HP:0002033)1.68629976
130Back pain (HP:0003418)1.68271810
131Aortic dissection (HP:0002647)1.67027304
132Calcaneovalgus deformity (HP:0001848)1.66960459
133Acute encephalopathy (HP:0006846)1.66936997
134Abnormality of the Achilles tendon (HP:0005109)1.66561570
135Pancreatic islet-cell hyperplasia (HP:0004510)1.65643813
136Abnormalities of placenta or umbilical cord (HP:0001194)1.65421931
137Chromsome breakage (HP:0040012)1.65251575
138Abnormality of subcutaneous fat tissue (HP:0001001)1.64766591
139Abnormality of the umbilical cord (HP:0010881)1.62984943
140Rhabdomyolysis (HP:0003201)1.58409872
141Multiple enchondromatosis (HP:0005701)1.58023164
142Arterial tortuosity (HP:0005116)1.56395282
143Dry hair (HP:0011359)1.55754340
144Myopathic facies (HP:0002058)1.55722447
145Ependymoma (HP:0002888)1.55408388
146Renal cortical cysts (HP:0000803)1.54307639
147Progressive muscle weakness (HP:0003323)1.54295088
148Meckel diverticulum (HP:0002245)1.54247945
149Deformed tarsal bones (HP:0008119)1.53172974
150Increased nuchal translucency (HP:0010880)1.52004016
151Type 2 muscle fiber atrophy (HP:0003554)1.51414341
152Neoplasm of the adrenal gland (HP:0100631)1.49736005
153Microvesicular hepatic steatosis (HP:0001414)1.49453612
154Decreased muscle mass (HP:0003199)1.48654460
155Trismus (HP:0000211)1.48213572
156Distal arthrogryposis (HP:0005684)1.47826198
157Muscle fiber atrophy (HP:0100295)1.45317781
158Abnormality of the ileum (HP:0001549)1.45273948
159Small epiphyses (HP:0010585)1.44250311

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK5.05665766
2PKN24.22189252
3LMTK23.91374172
4BUB13.54754216
5ERN13.50521634
6VRK23.43311976
7MST1R3.35504343
8FGFR43.30698712
9MAP3K102.85871529
10TRIB32.82533600
11FRK2.77750835
12SIK12.72257977
13TAF12.63641252
14CDC72.54898640
15EIF2AK12.45949008
16MUSK2.43881424
17PTK62.36174390
18SMG12.27316482
19GRK62.27143546
20TAOK32.22934686
21MAPKAPK52.18843080
22MAP2K22.17511565
23SRPK12.04673283
24MAPK111.93751799
25FLT31.93561701
26TSSK61.92939107
27CCNB11.84820662
28PLK31.83616626
29EIF2AK31.74633749
30ZAK1.72034676
31PRKG21.70803678
32INSRR1.69124848
33MAP2K61.68357980
34CDK81.62689918
35NEK21.57575875
36MYLK1.54177680
37STK161.53754712
38TTN1.52595000
39OBSCN1.51119094
40TBK11.49694266
41VRK11.49669645
42RIPK11.46224317
43ERBB41.39667403
44MAP3K111.35785983
45BRSK21.34618068
46EPHA21.31011233
47WEE11.30805104
48TYK21.27980039
49LIMK11.26188940
50DMPK1.25315138
51PLK11.24591626
52MKNK11.17979491
53MKNK21.17129658
54NEK11.15987940
55KDR1.15796332
56ERBB21.12681899
57PAK21.11907864
58PBK1.11419946
59CHEK21.10196290
60DAPK21.09308499
61PLK41.07978142
62PIK3CG1.05665403
63PIK3CA1.04943521
64LATS21.04696334
65MET1.04068657
66MAP3K71.04026537
67AURKB1.03184680
68CDK71.02080604
69LATS11.00949137
70PRKAA20.97673036
71EIF2AK20.94875732
72STK30.93744053
73MAP2K40.93632893
74BRSK10.89049049
75AURKA0.88301032
76NUAK10.86812266
77MAP3K30.84825662
78PDK40.83589036
79PDK30.83589036
80PTK20.83150210
81ATR0.82834132
82MAP2K10.82745374
83WNK30.82382794
84ABL20.79479479
85CSK0.78652656
86MELK0.77836420
87NEK90.76555212
88FGFR10.76528810
89EPHB20.76427687
90EEF2K0.76034769
91CDK40.75876853
92JAK20.75735820
93WNK40.75214886
94MAP3K20.73453564
95CDK90.72066519
96MAP3K80.70649681
97PDPK10.70472607
98MAP4K10.69531589
99PRKACG0.68463456
100TRIM280.66952602
101MAPK40.66821794
102CAMK1D0.65606239
103CSNK1G10.64721558
104NME20.64589151
105PHKG20.64234647
106PHKG10.64234647
107KSR20.63737870
108PRKAA10.61444233
109CHEK10.60034787
110CDK60.57884828
111CAMK2G0.57617229
112DYRK1B0.57003384
113MAP2K30.56384769
114CSNK1G30.55899661
115ALK0.55355412
116PDK10.54856531
117PRKCZ0.54134183
118TTK0.53439227
119STK390.53397039
120SCYL20.53017884
121CSNK2A20.51297508
122CSNK1E0.50501032
123TNIK0.50452595
124ICK0.50295535
125ATM0.49881239
126STK38L0.49761842
127MST40.49674700
128DYRK20.49654087
129EPHB10.49379002
130ILK0.49154792
131BCR0.46993981
132MAP3K10.46986297
133PRKCQ0.46448487
134CSNK2A10.45314235
135PIM20.44312661
136IKBKE0.43965406
137GSK3A0.43834609
138MATK0.43058846
139DAPK30.42883505
140LRRK20.42807213
141TAOK10.42640169
142BLK0.42463635
143TESK10.42177209
144ACVR1B0.42151638
145CDK10.42027631
146CSNK1A1L0.41677668
147PRKCI0.40619692
148TGFBR10.40225082
149DAPK10.38215696
150RPS6KB20.37757334
151JAK10.37675978
152PAK40.36026858
153MAP3K50.35845129
154NME10.35265713
155GRK10.32588119
156PRKCA0.32350445
157STK40.30545128
158MAPK120.30473131
159TIE10.30040490
160PAK30.29468146
161PDGFRA0.28436959
162STK100.27982851
163RET0.27270508
164MAP3K140.26331486
165AKT20.24258354
166CAMKK10.21869660

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009104.04484782
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.70834207
3* Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.25109418
4Arginine biosynthesis_Homo sapiens_hsa002203.17799345
5Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.13925585
6Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.65497173
7* Tryptophan metabolism_Homo sapiens_hsa003802.54721070
8* Fatty acid degradation_Homo sapiens_hsa000712.51661433
9Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.37377034
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.30617256
11* Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.24137568
12Complement and coagulation cascades_Homo sapiens_hsa046102.24061288
13Fat digestion and absorption_Homo sapiens_hsa049752.15038128
14Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.09419111
15Butanoate metabolism_Homo sapiens_hsa006502.08737203
16* Pentose and glucuronate interconversions_Homo sapiens_hsa000402.05998360
172-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.01199358
18Propanoate metabolism_Homo sapiens_hsa006401.94309695
19DNA replication_Homo sapiens_hsa030301.87625487
20Chemical carcinogenesis_Homo sapiens_hsa052041.81622980
21Sulfur metabolism_Homo sapiens_hsa009201.80279878
22Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.79670195
23Fatty acid metabolism_Homo sapiens_hsa012121.78804694
24Peroxisome_Homo sapiens_hsa041461.78186234
25PPAR signaling pathway_Homo sapiens_hsa033201.77425691
26* Histidine metabolism_Homo sapiens_hsa003401.76948102
27Drug metabolism - other enzymes_Homo sapiens_hsa009831.68765560
28Caffeine metabolism_Homo sapiens_hsa002321.65435770
29Maturity onset diabetes of the young_Homo sapiens_hsa049501.64682007
30Bile secretion_Homo sapiens_hsa049761.63357197
31Mismatch repair_Homo sapiens_hsa034301.61257007
32Steroid hormone biosynthesis_Homo sapiens_hsa001401.60178987
33Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.56904977
34Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.56298743
35Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.55998155
36Carbon metabolism_Homo sapiens_hsa012001.55374838
37Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.54584470
38Proteasome_Homo sapiens_hsa030501.54567350
39Selenocompound metabolism_Homo sapiens_hsa004501.52380645
40Starch and sucrose metabolism_Homo sapiens_hsa005001.47601274
41Retinol metabolism_Homo sapiens_hsa008301.47529001
42Biosynthesis of amino acids_Homo sapiens_hsa012301.47408150
43Staphylococcus aureus infection_Homo sapiens_hsa051501.42695790
44Cyanoamino acid metabolism_Homo sapiens_hsa004601.42602478
45* beta-Alanine metabolism_Homo sapiens_hsa004101.41535484
46* Pyruvate metabolism_Homo sapiens_hsa006201.40826556
47Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.37954117
48Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.36857168
49Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.35707922
50Folate biosynthesis_Homo sapiens_hsa007901.33419048
51Phenylalanine metabolism_Homo sapiens_hsa003601.33391141
52Cysteine and methionine metabolism_Homo sapiens_hsa002701.23201585
53Fatty acid elongation_Homo sapiens_hsa000621.22321337
54Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.18579135
55Tyrosine metabolism_Homo sapiens_hsa003501.13984826
56ABC transporters_Homo sapiens_hsa020101.13789809
57Vitamin digestion and absorption_Homo sapiens_hsa049771.12890787
58Base excision repair_Homo sapiens_hsa034101.09540647
59Non-homologous end-joining_Homo sapiens_hsa034501.07848984
60* Arginine and proline metabolism_Homo sapiens_hsa003301.07505686
61RNA polymerase_Homo sapiens_hsa030201.07052964
62Steroid biosynthesis_Homo sapiens_hsa001001.06269914
63Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.98154215
64Pentose phosphate pathway_Homo sapiens_hsa000300.97872153
65Glutathione metabolism_Homo sapiens_hsa004800.97395158
66Pyrimidine metabolism_Homo sapiens_hsa002400.96890496
67Sulfur relay system_Homo sapiens_hsa041220.94989797
68Nucleotide excision repair_Homo sapiens_hsa034200.94545217
69RNA transport_Homo sapiens_hsa030130.94476065
70* Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.92065509
71Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.91839161
72Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.91247533
73Homologous recombination_Homo sapiens_hsa034400.84523023
74Cell cycle_Homo sapiens_hsa041100.82004444
75Galactose metabolism_Homo sapiens_hsa000520.81406326
76Spliceosome_Homo sapiens_hsa030400.81011112
77Fructose and mannose metabolism_Homo sapiens_hsa000510.79138409
78Protein export_Homo sapiens_hsa030600.78286058
79One carbon pool by folate_Homo sapiens_hsa006700.75846518
80* Glycerolipid metabolism_Homo sapiens_hsa005610.71978414
81Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.70324205
82* Lysine degradation_Homo sapiens_hsa003100.68060094
83Ribosome_Homo sapiens_hsa030100.67325595
84Fanconi anemia pathway_Homo sapiens_hsa034600.53895239
85* Metabolic pathways_Homo sapiens_hsa011000.50765500
86Vitamin B6 metabolism_Homo sapiens_hsa007500.47388205
87Purine metabolism_Homo sapiens_hsa002300.47026762
88Basal transcription factors_Homo sapiens_hsa030220.44789272
89Huntingtons disease_Homo sapiens_hsa050160.42745197
90RNA degradation_Homo sapiens_hsa030180.41834048
91N-Glycan biosynthesis_Homo sapiens_hsa005100.41015107
92Systemic lupus erythematosus_Homo sapiens_hsa053220.40458211
93Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.38894074
94Fatty acid biosynthesis_Homo sapiens_hsa000610.38681199
95Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.37449441
96Renin-angiotensin system_Homo sapiens_hsa046140.35807246
97p53 signaling pathway_Homo sapiens_hsa041150.34824663
98Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.34393693
99Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.34213232
100Mineral absorption_Homo sapiens_hsa049780.33437887
101mRNA surveillance pathway_Homo sapiens_hsa030150.29951182
102Hippo signaling pathway_Homo sapiens_hsa043900.29482026
103Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.27872727
104alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.22747372
105Insulin resistance_Homo sapiens_hsa049310.21364383
106Linoleic acid metabolism_Homo sapiens_hsa005910.14137764
107Protein digestion and absorption_Homo sapiens_hsa049740.14053049
108Carbohydrate digestion and absorption_Homo sapiens_hsa049730.12418610
109Adipocytokine signaling pathway_Homo sapiens_hsa049200.10527268
110Glycerophospholipid metabolism_Homo sapiens_hsa005640.09053151
111Parkinsons disease_Homo sapiens_hsa050120.08830363
112Oxidative phosphorylation_Homo sapiens_hsa001900.06246701
113Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.04879616
114Prion diseases_Homo sapiens_hsa050200.03475467
115Glucagon signaling pathway_Homo sapiens_hsa049220.02486368
116RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622-0.1741409
117Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512-0.1571526
118Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1448488
119Intestinal immune network for IgA production_Homo sapiens_hsa04672-0.1314271
120Pertussis_Homo sapiens_hsa05133-0.1230325
121Pancreatic secretion_Homo sapiens_hsa04972-0.1219379
122Insulin signaling pathway_Homo sapiens_hsa04910-0.1185164
123Bladder cancer_Homo sapiens_hsa05219-0.1068952
124African trypanosomiasis_Homo sapiens_hsa05143-0.0891142
125Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.0718509
126Thyroid hormone synthesis_Homo sapiens_hsa04918-0.0626439
127AMPK signaling pathway_Homo sapiens_hsa04152-0.0243588
128Alzheimers disease_Homo sapiens_hsa05010-0.0164428
129Hepatitis C_Homo sapiens_hsa05160-0.0024751

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