ALDH16A1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the aldehyde dehydrogenase superfamily. The family members act on aldehyde substrates and use nicotinamide adenine dinucleotide phosphate (NADP) as a cofactor. This gene is conserved in chimpanzee, dog, cow, mouse, rat, and zebrafish. The protein encoded by this gene interacts with maspardin, a protein that when truncated is responsible for Mast syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.70751053
2L-phenylalanine metabolic process (GO:0006558)4.70751053
3aromatic amino acid family catabolic process (GO:0009074)4.53822781
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.53232340
5L-phenylalanine catabolic process (GO:0006559)4.53232340
6indole-containing compound catabolic process (GO:0042436)4.52368349
7indolalkylamine catabolic process (GO:0046218)4.52368349
8tryptophan catabolic process (GO:0006569)4.52368349
9tryptophan metabolic process (GO:0006568)4.27015447
10kynurenine metabolic process (GO:0070189)4.22321924
11glyoxylate metabolic process (GO:0046487)4.12142348
12glycine metabolic process (GO:0006544)4.08069393
13triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.02554548
14sulfur amino acid catabolic process (GO:0000098)4.01424577
15positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.99978067
16positive regulation of gamma-delta T cell activation (GO:0046645)3.97048654
17cysteine metabolic process (GO:0006534)3.85174495
18serine family amino acid catabolic process (GO:0009071)3.84129636
19urea metabolic process (GO:0019627)3.82613090
20urea cycle (GO:0000050)3.82613090
21immunoglobulin mediated immune response (GO:0016064)3.82298700
22antigen processing and presentation of endogenous antigen (GO:0019883)3.80131260
23response to peptidoglycan (GO:0032494)3.79483607
24serine family amino acid biosynthetic process (GO:0009070)3.78372093
25antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.74032627
26homocysteine metabolic process (GO:0050667)3.68285442
27serine family amino acid metabolic process (GO:0009069)3.64214655
28antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.60396149
29bile acid biosynthetic process (GO:0006699)3.56988388
30negative regulation of cell killing (GO:0031342)3.53469132
31negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.53469132
32high-density lipoprotein particle remodeling (GO:0034375)3.52489294
33nitrogen cycle metabolic process (GO:0071941)3.52404838
34negative regulation of phagocytosis (GO:0050765)3.51484904
35fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.48563794
36positive regulation of B cell differentiation (GO:0045579)3.47474928
37DNA deamination (GO:0045006)3.46201925
38negative regulation of erythrocyte differentiation (GO:0045647)3.43062537
39aromatic amino acid family metabolic process (GO:0009072)3.40063168
40regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.39439778
41amino-acid betaine metabolic process (GO:0006577)3.36819690
42regulation of interferon-beta biosynthetic process (GO:0045357)3.34415099
43deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.33946104
44positive regulation of histone deacetylation (GO:0031065)3.33850870
45imidazole-containing compound metabolic process (GO:0052803)3.33778348
46NIK/NF-kappaB signaling (GO:0038061)3.31902447
47proline metabolic process (GO:0006560)3.28956730
48complement activation, alternative pathway (GO:0006957)3.28408214
49neutrophil activation involved in immune response (GO:0002283)3.27731710
50cellular biogenic amine catabolic process (GO:0042402)3.27073121
51amine catabolic process (GO:0009310)3.27073121
52regulation of triglyceride catabolic process (GO:0010896)3.26906770
53negative regulation of fibrinolysis (GO:0051918)3.23621354
54lysine metabolic process (GO:0006553)3.22551440
55lysine catabolic process (GO:0006554)3.22551440
56negative regulation of cholesterol transport (GO:0032375)3.22355363
57negative regulation of sterol transport (GO:0032372)3.22355363
58protein carboxylation (GO:0018214)3.21841423
59peptidyl-glutamic acid carboxylation (GO:0017187)3.21841423
60antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.21710419
61mannose metabolic process (GO:0006013)3.19954214
62regulation of mast cell degranulation (GO:0043304)3.19290163
63NAD biosynthetic process (GO:0009435)3.18360488
64regulation of protein activation cascade (GO:2000257)3.18008040
65L-serine metabolic process (GO:0006563)3.17999432
66bile acid metabolic process (GO:0008206)3.16773224
67regulation of cholesterol esterification (GO:0010872)3.16414595
68proline biosynthetic process (GO:0006561)3.16267689
69modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.13750285
70positive regulation by organism of defense response of other organism involved in symbiotic interact3.13750285
71modulation by symbiont of host immune response (GO:0052553)3.13750285
72positive regulation by symbiont of host defense response (GO:0052509)3.13750285
73modulation by symbiont of host defense response (GO:0052031)3.13750285
74modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.13750285
75detection of bacterium (GO:0016045)3.12961412
76indolalkylamine metabolic process (GO:0006586)3.12793076
77phospholipid efflux (GO:0033700)3.12759019
78alpha-amino acid catabolic process (GO:1901606)3.11035069
79positive thymic T cell selection (GO:0045059)3.10096271
80positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.09758995
81regulation of gamma-delta T cell activation (GO:0046643)3.09702199
82alpha-linolenic acid metabolic process (GO:0036109)3.08572789
83regulation of fibrinolysis (GO:0051917)3.08020803
84triglyceride homeostasis (GO:0070328)3.06087402
85acylglycerol homeostasis (GO:0055090)3.06087402
86B cell mediated immunity (GO:0019724)3.05900170
87cellular glucuronidation (GO:0052695)3.02963288
88pyridine nucleotide biosynthetic process (GO:0019363)3.02149097
89nicotinamide nucleotide biosynthetic process (GO:0019359)3.02149097
90positive regulation of protein deacetylation (GO:0090312)3.01130655
91regulation of gamma-delta T cell differentiation (GO:0045586)3.00682419
92reverse cholesterol transport (GO:0043691)3.00352576
93plasma lipoprotein particle assembly (GO:0034377)2.99750687
94regulation of mast cell activation involved in immune response (GO:0033006)2.99550616
95bile acid and bile salt transport (GO:0015721)2.99386093
96protein-lipid complex remodeling (GO:0034368)2.98748145
97macromolecular complex remodeling (GO:0034367)2.98748145
98plasma lipoprotein particle remodeling (GO:0034369)2.98748145
99tetrahydrofolate metabolic process (GO:0046653)2.98384128
100negative regulation of interleukin-12 production (GO:0032695)2.97275445
101regulation of complement activation (GO:0030449)2.96919613
102pentose metabolic process (GO:0019321)2.94435520
103T cell apoptotic process (GO:0070231)2.94327002
104positive regulation of antigen processing and presentation (GO:0002579)2.94158104
105positive regulation of lipoprotein lipase activity (GO:0051006)2.92635298
106positive regulation of triglyceride lipase activity (GO:0061365)2.92635298
107regulation of B cell apoptotic process (GO:0002902)2.92325477
108ethanol oxidation (GO:0006069)2.91821083
109very-low-density lipoprotein particle assembly (GO:0034379)2.90266145
110detection of other organism (GO:0098543)2.88532949
111aldehyde catabolic process (GO:0046185)2.88093382
112cellular amino acid catabolic process (GO:0009063)2.87211658
113response to nitrosative stress (GO:0051409)2.86878405
114intestinal cholesterol absorption (GO:0030299)2.85370765
115blood coagulation, intrinsic pathway (GO:0007597)2.84665641
116defense response to protozoan (GO:0042832)2.83579536
117regulation of B cell receptor signaling pathway (GO:0050855)2.82503889
118folic acid-containing compound biosynthetic process (GO:0009396)2.82360124
119regulation of B cell differentiation (GO:0045577)2.78923286
120telomere maintenance via semi-conservative replication (GO:0032201)2.78673791
121regulation of antigen processing and presentation (GO:0002577)2.78538698
122glutamine family amino acid biosynthetic process (GO:0009084)2.78300565
123response to protozoan (GO:0001562)2.78197438
124benzene-containing compound metabolic process (GO:0042537)2.77748117
125negative regulation of fatty acid biosynthetic process (GO:0045717)2.77102841
126thymic T cell selection (GO:0045061)2.76750835
127plasma lipoprotein particle clearance (GO:0034381)2.76288187
128amyloid precursor protein catabolic process (GO:0042987)2.76055321
129regulation of T cell tolerance induction (GO:0002664)2.74509019
130regulation of myeloid leukocyte mediated immunity (GO:0002886)2.74296604
131one-carbon metabolic process (GO:0006730)2.73876768
132B cell receptor signaling pathway (GO:0050853)2.73686548
133pteridine-containing compound biosynthetic process (GO:0042559)2.72454940
134tyrosine metabolic process (GO:0006570)2.72409271
135urate metabolic process (GO:0046415)2.72125899
136ribosomal small subunit assembly (GO:0000028)2.72114872
137cholesterol efflux (GO:0033344)2.71933633
138positive regulation of mast cell degranulation (GO:0043306)2.71425251
139positive regulation of mast cell activation involved in immune response (GO:0033008)2.71425251
140positive regulation of interferon-alpha production (GO:0032727)2.71384703
141regulation of mast cell activation (GO:0033003)2.70415422
142cellular modified amino acid catabolic process (GO:0042219)2.70165949
143positive regulation of lymphocyte apoptotic process (GO:0070230)2.70033044
144macrophage activation involved in immune response (GO:0002281)2.69850378
145response to type I interferon (GO:0034340)2.69202349
146cholesterol homeostasis (GO:0042632)2.69149525
147drug catabolic process (GO:0042737)2.68643294
148folic acid metabolic process (GO:0046655)2.68362567
149response to interferon-beta (GO:0035456)2.67491189
150carnitine metabolic process (GO:0009437)2.67244913
151uronic acid metabolic process (GO:0006063)2.66251273
152glucuronate metabolic process (GO:0019585)2.66251273
153leukocyte aggregation (GO:0070486)2.65635627
154DNA strand elongation involved in DNA replication (GO:0006271)2.65133495
155regulation of interferon-alpha production (GO:0032647)2.65065561
156negative regulation of innate immune response (GO:0045824)2.64951127
157regulation of leukocyte degranulation (GO:0043300)2.64857996
158type I interferon signaling pathway (GO:0060337)2.63652449
159cellular response to type I interferon (GO:0071357)2.63652449
160valine metabolic process (GO:0006573)2.63418927
161sterol homeostasis (GO:0055092)2.61959722
162T cell selection (GO:0045058)2.61825624
163primary alcohol catabolic process (GO:0034310)2.61671087
164negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.61636667
165positive regulation of mast cell activation (GO:0033005)2.61620573
166protein-lipid complex assembly (GO:0065005)2.61430953
167lymphocyte apoptotic process (GO:0070227)2.60638318
168leukocyte apoptotic process (GO:0071887)2.59245268
169response to muramyl dipeptide (GO:0032495)2.59236141
170carboxylic acid catabolic process (GO:0046395)2.58337096
171organic acid catabolic process (GO:0016054)2.58337096
172negative thymic T cell selection (GO:0045060)2.55376805
173negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.54778674
174tolerance induction (GO:0002507)2.54224580
175regulation of type I interferon-mediated signaling pathway (GO:0060338)2.52123377
176programmed necrotic cell death (GO:0097300)2.51287874
177autophagic vacuole fusion (GO:0000046)2.48070341
178Peyers patch development (GO:0048541)2.47715755
179mucosal-associated lymphoid tissue development (GO:0048537)2.47715755
180amino sugar catabolic process (GO:0046348)2.46312569
181cellular response to interferon-beta (GO:0035458)2.45250647
182regulation of defense response to virus by host (GO:0050691)2.43821400
183cellular response to virus (GO:0098586)2.42727911
184antigen processing and presentation via MHC class Ib (GO:0002475)2.42683948
185cellular response to exogenous dsRNA (GO:0071360)2.41940369
186CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.41727189
187positive regulation of T cell apoptotic process (GO:0070234)2.41563476
188regulation of tolerance induction (GO:0002643)2.40158654
189negative T cell selection (GO:0043383)2.39825317
190myeloid cell activation involved in immune response (GO:0002275)2.39823834
191regulation of dendritic cell antigen processing and presentation (GO:0002604)2.38881910
192positive regulation of defense response to virus by host (GO:0002230)2.38331900
193respiratory burst (GO:0045730)2.38006161
194positive regulation of Cdc42 GTPase activity (GO:0043089)2.36781031
195purine deoxyribonucleotide catabolic process (GO:0009155)2.35988810
196negative regulation of B cell apoptotic process (GO:0002903)2.35364561
197regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.34837943
198positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.33573508
199negative regulation of interleukin-6 production (GO:0032715)2.32326664
200interferon-gamma-mediated signaling pathway (GO:0060333)2.30570096

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.52655599
2E2F7_22180533_ChIP-Seq_HELA_Human5.37002416
3RXR_22158963_ChIP-Seq_LIVER_Mouse3.85989031
4PPARA_22158963_ChIP-Seq_LIVER_Mouse3.59983391
5EGR1_23403033_ChIP-Seq_LIVER_Mouse3.52719563
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.12408071
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.73322703
8PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.68504774
9LXR_22158963_ChIP-Seq_LIVER_Mouse2.66577952
10CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.60005981
11* MYC_18555785_ChIP-Seq_MESCs_Mouse2.54803205
12TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.30906967
13* LXR_22292898_ChIP-Seq_THP-1_Human2.20721869
14IRF8_22096565_ChIP-ChIP_GC-B_Human2.14549394
15FOXM1_23109430_ChIP-Seq_U2OS_Human2.04504829
16FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.00523851
17FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.00045735
18E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.95662668
19ELF1_17652178_ChIP-ChIP_JURKAT_Human1.91379770
20MYC_18358816_ChIP-ChIP_MESCs_Mouse1.89159812
21BCL6_27268052_Chip-Seq_Bcells_Human1.86923976
22P68_20966046_ChIP-Seq_HELA_Human1.80138909
23* ELK3_25401928_ChIP-Seq_HUVEC_Human1.76570373
24E2F4_17652178_ChIP-ChIP_JURKAT_Human1.74584863
25KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.74395218
26ELF1_20517297_ChIP-Seq_JURKAT_Human1.74344523
27MAF_26560356_Chip-Seq_TH2_Human1.74060911
28BCOR_27268052_Chip-Seq_Bcells_Human1.71952893
29SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.70103885
30VDR_21846776_ChIP-Seq_THP-1_Human1.63580986
31KDM2B_26808549_Chip-Seq_SUP-B15_Human1.63071180
32JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.62391121
33MYC_19030024_ChIP-ChIP_MESCs_Mouse1.62379737
34TET1_21451524_ChIP-Seq_MESCs_Mouse1.58963331
35MYC_19079543_ChIP-ChIP_MESCs_Mouse1.58291254
36* STAT3_1855785_ChIP-Seq_MESCs_Mouse1.50742435
37MYC_22102868_ChIP-Seq_BL_Human1.49085811
38HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.48743263
39KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.47013846
40TCF7_22412390_ChIP-Seq_EML_Mouse1.46036118
41* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.45403745
42KDM2B_26808549_Chip-Seq_DND41_Human1.43997486
43* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.43761396
44* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.43233648
45BP1_19119308_ChIP-ChIP_Hs578T_Human1.42646173
46FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.42312355
47SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.40852719
48NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.40364480
49MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.38951813
50CTCF_26484167_Chip-Seq_Bcells_Mouse1.38371463
51SCL_19346495_ChIP-Seq_HPC-7_Human1.38137640
52SA1_27219007_Chip-Seq_ERYTHROID_Human1.36619460
53IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.36401777
54NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.36083225
55NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.35969633
56RACK7_27058665_Chip-Seq_MCF-7_Human1.35739235
57PU.1_20513432_ChIP-Seq_Bcells_Mouse1.34310666
58STAT6_21828071_ChIP-Seq_BEAS2B_Human1.33393655
59E2F1_20622854_ChIP-Seq_HELA_Human1.33241896
60CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.32989740
61IRF8_21731497_ChIP-ChIP_J774_Mouse1.31807497
62ETS1_20019798_ChIP-Seq_JURKAT_Human1.31758353
63DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.31329316
64PHF8_20622854_ChIP-Seq_HELA_Human1.30626753
65* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.30517099
66NELFA_20434984_ChIP-Seq_ESCs_Mouse1.29712650
67SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.29142870
68STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.28916893
69* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.28867066
70MYB_26560356_Chip-Seq_TH2_Human1.28534089
71CTCF_27219007_Chip-Seq_ERYTHROID_Human1.28032697
72KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.26234352
73EST1_17652178_ChIP-ChIP_JURKAT_Human1.26073556
74SRY_22984422_ChIP-ChIP_TESTIS_Rat1.26038503
75NANOG_18555785_ChIP-Seq_MESCs_Mouse1.24466167
76* XRN2_22483619_ChIP-Seq_HELA_Human1.23510192
77IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.22606825
78NCOR1_26117541_ChIP-Seq_K562_Human1.22471870
79CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.22001993
80BRD4_27068464_Chip-Seq_AML-cells_Mouse1.21686628
81FOXP3_21729870_ChIP-Seq_TREG_Human1.21285790
82MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.20908673
83PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.20720695
84YY1_22570637_ChIP-Seq_MALME-3M_Human1.20252360
85AR_21909140_ChIP-Seq_LNCAP_Human1.19794600
86DCP1A_22483619_ChIP-Seq_HELA_Human1.19760227
87GABP_17652178_ChIP-ChIP_JURKAT_Human1.19475897
88EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.18464735
89IRF8_27001747_Chip-Seq_BMDM_Mouse1.18175698
90SRF_21415370_ChIP-Seq_HL-1_Mouse1.16815497
91SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.16282116
92EGR1_19374776_ChIP-ChIP_THP-1_Human1.15198233
93GATA1_22383799_ChIP-Seq_G1ME_Mouse1.15124579
94STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.14876777
95CTCF_21964334_ChIP-Seq_BJAB-B_Human1.14544473
96SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.13773755
97STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.13214045
98* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.13163772
99MYB_21317192_ChIP-Seq_ERMYB_Mouse1.13138732
100* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.12587412
101SPI1_23547873_ChIP-Seq_NB4_Human1.12341790
102CREB1_15753290_ChIP-ChIP_HEK293T_Human1.11212175
103RARB_24833708_ChIP-Seq_LIVER_Mouse1.11147656
104ERG_20887958_ChIP-Seq_HPC-7_Mouse1.11067484
105* CTCF_18555785_ChIP-Seq_MESCs_Mouse1.10687180
106TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.10545916
107TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.10527627
108POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.10420341
109CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.10398134
110E2F1_21310950_ChIP-Seq_MCF-7_Human1.09891492
111P300_27268052_Chip-Seq_Bcells_Human1.09538252
112SPI1_23127762_ChIP-Seq_K562_Human1.09176766
113VDR_23849224_ChIP-Seq_CD4+_Human1.07776581
114CTCF_21964334_Chip-Seq_Bcells_Human1.07719727
115HOXB4_20404135_ChIP-ChIP_EML_Mouse1.07312641
116GATA2_22383799_ChIP-Seq_G1ME_Mouse1.06992286
117ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.06534510
118PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.06514600
119THAP11_20581084_ChIP-Seq_MESCs_Mouse1.05858578
120SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.05725839
121NOTCH1_21737748_ChIP-Seq_TLL_Human1.05596244
122SMC4_20622854_ChIP-Seq_HELA_Human1.05535038
123CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.05193066
124THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.04810581
125MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.04794338
126NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.04503467
127GATA1_22025678_ChIP-Seq_K562_Human1.04060124
128GABP_19822575_ChIP-Seq_HepG2_Human1.01973796
129YY1_21170310_ChIP-Seq_MESCs_Mouse0.99934828
130TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.99255393
131RXRA_24833708_ChIP-Seq_LIVER_Mouse0.99172759
132MAF_26560356_Chip-Seq_TH1_Human0.98830174
133RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.98280429
134RUNX1_22412390_ChIP-Seq_EML_Mouse0.97878633
135SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.95923894
136CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.95721074
137POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.95701298
138KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.92828335
139TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.92612332
140NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.92416737
141MYB_26560356_Chip-Seq_TH1_Human0.92243987
142HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.92140141
143SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.91820208
144* ZFX_18555785_ChIP-Seq_MESCs_Mouse0.90961526
145ESR1_15608294_ChIP-ChIP_MCF-7_Human0.89111281
146KDM5A_27292631_Chip-Seq_BREAST_Human0.89099150
147MYCN_18555785_ChIP-Seq_MESCs_Mouse0.88466433
148CIITA_25753668_ChIP-Seq_RAJI_Human0.86688151
149UTX_26944678_Chip-Seq_JUKART_Human0.86441856
150VDR_24763502_ChIP-Seq_THP-1_Human0.85009445
151FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.83963491
152TCF3_18692474_ChIP-Seq_MEFs_Mouse0.83439233
153SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.83292416
154CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.83021437

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis5.38390081
2MP0002139_abnormal_hepatobiliary_system5.16874777
3MP0005085_abnormal_gallbladder_physiolo4.24295582
4MP0005365_abnormal_bile_salt3.96590269
5MP0003806_abnormal_nucleotide_metabolis3.48086603
6MP0008875_abnormal_xenobiotic_pharmacok3.23918912
7MP0009840_abnormal_foam_cell2.88136803
8MP0003252_abnormal_bile_duct2.60245628
9MP0003172_abnormal_lysosome_physiology2.31126843
10MP0003303_peritoneal_inflammation2.25491997
11MP0003191_abnormal_cellular_cholesterol2.16114725
12MP0010329_abnormal_lipoprotein_level2.15783300
13MP0001666_abnormal_nutrient_absorption2.02302787
14MP0005332_abnormal_amino_acid1.95551166
15MP0004019_abnormal_vitamin_homeostasis1.88538374
16MP0005083_abnormal_biliary_tract1.68611516
17MP0000609_abnormal_liver_physiology1.65353860
18MP0008057_abnormal_DNA_replication1.63191663
19MP0003186_abnormal_redox_activity1.61621293
20MP0002138_abnormal_hepatobiliary_system1.61209778
21MP0003693_abnormal_embryo_hatching1.55687398
22MP0004381_abnormal_hair_follicle1.55137968
23MP0001764_abnormal_homeostasis1.54695772
24MP0005310_abnormal_salivary_gland1.52786570
25MP0005319_abnormal_enzyme/_coenzyme1.51452104
26MP0003195_calcinosis1.50845712
27MP0001835_abnormal_antigen_presentation1.49217628
28MP0008260_abnormal_autophagy1.48577725
29MP0000703_abnormal_thymus_morphology1.47258874
30MP0004947_skin_inflammation1.42576673
31MP0003436_decreased_susceptibility_to1.42273937
32MP0002396_abnormal_hematopoietic_system1.42000005
33MP0000015_abnormal_ear_pigmentation1.39875149
34MP0001533_abnormal_skeleton_physiology1.38653166
35MP0000490_abnormal_crypts_of1.31334737
36MP0010094_abnormal_chromosome_stability1.29666058
37MP0009697_abnormal_copulation1.26066441
38MP0000685_abnormal_immune_system1.24903307
39MP0005464_abnormal_platelet_physiology1.22667049
40MP0009643_abnormal_urine_homeostasis1.22355875
41MP0003111_abnormal_nucleus_morphology1.21696463
42MP0009785_altered_susceptibility_to1.21381241
43MP0000598_abnormal_liver_morphology1.19720744
44MP0005075_abnormal_melanosome_morpholog1.19207074
45MP0008469_abnormal_protein_level1.17263227
46MP0002118_abnormal_lipid_homeostasis1.15506422
47MP0002132_abnormal_respiratory_system1.14998161
48MP0003656_abnormal_erythrocyte_physiolo1.14193862
49MP0004808_abnormal_hematopoietic_stem1.13988110
50MP0005451_abnormal_body_composition1.13677069
51MP0005025_abnormal_response_to1.12777790
52MP0003724_increased_susceptibility_to1.11399823
53MP0010155_abnormal_intestine_physiology1.10781248
54MP0005397_hematopoietic_system_phenotyp1.10518279
55MP0001545_abnormal_hematopoietic_system1.10518279
56MP0003300_gastrointestinal_ulcer1.09121853
57MP0004957_abnormal_blastocyst_morpholog1.09117690
58MP0003868_abnormal_feces_composition1.06226507
59MP0004185_abnormal_adipocyte_glucose1.06150391
60MP0000678_abnormal_parathyroid_gland1.06140830
61MP0003183_abnormal_peptide_metabolism1.05464983
62MP0001800_abnormal_humoral_immune1.04260018
63MP0009278_abnormal_bone_marrow1.03659401
64MP0001873_stomach_inflammation1.03075494
65MP0003866_abnormal_defecation1.02379454
66MP0010352_gastrointestinal_tract_polyps1.01965616
67MP0003077_abnormal_cell_cycle1.00988481
68MP0005058_abnormal_lysosome_morphology1.00706515
69MP0001663_abnormal_digestive_system1.00346139
70MP0009764_decreased_sensitivity_to0.99255160
71MP0005584_abnormal_enzyme/coenzyme_acti0.98533233
72MP0008058_abnormal_DNA_repair0.98321289
73MP0002419_abnormal_innate_immunity0.97951978
74MP0009763_increased_sensitivity_to0.97167940
75MP0001853_heart_inflammation0.96965900
76MP0000858_altered_metastatic_potential0.96046174
77MP0005174_abnormal_tail_pigmentation0.94700204
78MP0003705_abnormal_hypodermis_morpholog0.94662147
79MP0000689_abnormal_spleen_morphology0.94581457
80MP0005670_abnormal_white_adipose0.94195867
81MP0002163_abnormal_gland_morphology0.94086986
82MP0002277_abnormal_respiratory_mucosa0.91522354
83MP0000372_irregular_coat_pigmentation0.91418093
84MP0009333_abnormal_splenocyte_physiolog0.90321919
85MP0002452_abnormal_antigen_presenting0.88248749
86MP0003718_maternal_effect0.88153466
87MP0001845_abnormal_inflammatory_respons0.87793766
88MP0001849_ear_inflammation0.85383848
89MP0002166_altered_tumor_susceptibility0.84629938
90MP0004264_abnormal_extraembryonic_tissu0.84277900
91MP0003075_altered_response_to0.83159824
92MP0002722_abnormal_immune_system0.83097703
93MP0005387_immune_system_phenotype0.82614257
94MP0001790_abnormal_immune_system0.82614257
95MP0002723_abnormal_immune_serum0.82584667
96MP0006082_CNS_inflammation0.82250025
97MP0002019_abnormal_tumor_incidence0.81660101
98MP0003453_abnormal_keratinocyte_physiol0.79680906
99MP0002254_reproductive_system_inflammat0.79617053
100MP0002398_abnormal_bone_marrow0.79120740
101MP0003011_delayed_dark_adaptation0.78289446
102MP0006036_abnormal_mitochondrial_physio0.78008989
103MP0010307_abnormal_tumor_latency0.77561724
104MP0002429_abnormal_blood_cell0.77526613
105MP0005076_abnormal_cell_differentiation0.76885098
106MP0005647_abnormal_sex_gland0.76528294
107MP0003878_abnormal_ear_physiology0.76371750
108MP0005377_hearing/vestibular/ear_phenot0.76371750
109MP0002405_respiratory_system_inflammati0.75727139
110MP0002998_abnormal_bone_remodeling0.75098397
111MP0003763_abnormal_thymus_physiology0.75008883
112MP0000716_abnormal_immune_system0.74526420
113MP0002970_abnormal_white_adipose0.74401354
114MP0002136_abnormal_kidney_physiology0.74000967
115MP0001819_abnormal_immune_cell0.73799098
116MP0002420_abnormal_adaptive_immunity0.72959164
117MP0005000_abnormal_immune_tolerance0.71801537
118MP0000371_diluted_coat_color0.71167055
119MP0000313_abnormal_cell_death0.71012526
120MP0000477_abnormal_intestine_morphology0.70067746
121MP0005636_abnormal_mineral_homeostasis0.69981234
122MP0002148_abnormal_hypersensitivity_rea0.69700154
123MP0005376_homeostasis/metabolism_phenot0.69468060
124MP0009765_abnormal_xenobiotic_induced0.69266607
125MP0005390_skeleton_phenotype0.68741012
126MP0004510_myositis0.68434740
127MP0005381_digestive/alimentary_phenotyp0.68124817
128MP0009642_abnormal_blood_homeostasis0.67819590
129MP0000465_gastrointestinal_hemorrhage0.67263589
130MP0002060_abnormal_skin_morphology0.67033770
131MP0003786_premature_aging0.67000532
132MP0000681_abnormal_thyroid_gland0.66742793
133MP0002693_abnormal_pancreas_physiology0.66688095
134MP0005266_abnormal_metabolism0.66626112
135MP0005379_endocrine/exocrine_gland_phen0.66526034
136MP0009931_abnormal_skin_appearance0.65610457
137MP0005671_abnormal_response_to0.64386975

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of monocarboxylic acid metabolism (HP:0010996)5.02954281
2Abnormality of aromatic amino acid family metabolism (HP:0004338)4.91360369
3Intrahepatic cholestasis (HP:0001406)4.89223080
4Increased neuronal autofluorescent lipopigment (HP:0002074)4.84391201
5Increased cerebral lipofuscin (HP:0011813)4.58658200
6Hypobetalipoproteinemia (HP:0003563)4.46070078
7Abnormality of pyrimidine metabolism (HP:0004353)4.43300381
8Recurrent abscess formation (HP:0002722)4.41122452
9Xanthomatosis (HP:0000991)4.14086227
10Prolonged partial thromboplastin time (HP:0003645)4.12025003
11Deep venous thrombosis (HP:0002625)4.04866250
12Abnormal delayed hypersensitivity skin test (HP:0002963)3.79035686
13Elevated erythrocyte sedimentation rate (HP:0003565)3.78676614
14Eczematoid dermatitis (HP:0000976)3.74632030
15Joint hemorrhage (HP:0005261)3.67782711
16Panhypogammaglobulinemia (HP:0003139)3.64905546
17Hyperammonemia (HP:0001987)3.57811529
18Abnormality of glutamine family amino acid metabolism (HP:0010902)3.57380120
19Recurrent fungal infections (HP:0002841)3.57324164
20Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.50007832
21Abnormality of sulfur amino acid metabolism (HP:0004339)3.43645033
22Recurrent skin infections (HP:0001581)3.42748323
23Chronic mucocutaneous candidiasis (HP:0002728)3.42128377
24Recurrent cutaneous fungal infections (HP:0011370)3.42128377
25Hyperglycinuria (HP:0003108)3.38244650
26Abnormality of macrophages (HP:0004311)3.37966940
27Obstructive lung disease (HP:0006536)3.34190855
28Chronic obstructive pulmonary disease (HP:0006510)3.34190855
29Mediastinal lymphadenopathy (HP:0100721)3.30402044
30Abnormality of aspartate family amino acid metabolism (HP:0010899)3.29288744
31Abnormality of liposaccharide metabolism (HP:0010968)3.23663425
32Abnormality of glycosphingolipid metabolism (HP:0004343)3.23663425
33Abnormality of glycolipid metabolism (HP:0010969)3.23663425
34Hyperlipoproteinemia (HP:0010980)3.23149546
35Hypolipoproteinemia (HP:0010981)3.21404042
36Recurrent viral infections (HP:0004429)3.20349153
37Abnormality of methionine metabolism (HP:0010901)3.19088289
38Complement deficiency (HP:0004431)3.17048307
39Colitis (HP:0002583)3.07747097
40Agammaglobulinemia (HP:0004432)3.06497615
41Myositis (HP:0100614)3.05537962
42Gastrointestinal inflammation (HP:0004386)3.05373417
43Abnormality of glycine metabolism (HP:0010895)3.03564951
44Abnormality of serine family amino acid metabolism (HP:0010894)3.03564951
45Meningitis (HP:0001287)3.03410166
46Hyperglycinemia (HP:0002154)3.01910795
47Inflammation of the large intestine (HP:0002037)2.96107186
48Stomatitis (HP:0010280)2.95768107
49Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.95181537
50Abnormality of fatty-acid metabolism (HP:0004359)2.89013880
51Abnormality of complement system (HP:0005339)2.88390410
52Abnormality of nucleobase metabolism (HP:0010932)2.86784708
53Fat malabsorption (HP:0002630)2.84472062
54Ketosis (HP:0001946)2.78138464
55Hypoglycemic coma (HP:0001325)2.73709789
56Dysostosis multiplex (HP:0000943)2.69748375
57Epidermoid cyst (HP:0200040)2.62826313
58Hypoalphalipoproteinemia (HP:0003233)2.61400426
59Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.61113463
60Abnormality of the common coagulation pathway (HP:0010990)2.56754360
61Reticulocytopenia (HP:0001896)2.56752933
62Pustule (HP:0200039)2.56575076
63Encephalitis (HP:0002383)2.55214857
64Myocardial infarction (HP:0001658)2.54428613
65Dicarboxylic aciduria (HP:0003215)2.53783842
66Abnormality of dicarboxylic acid metabolism (HP:0010995)2.53783842
67Gingival bleeding (HP:0000225)2.53191682
68Abnormality of T cells (HP:0002843)2.50985776
69Hyperbilirubinemia (HP:0002904)2.47918411
70Hypercholesterolemia (HP:0003124)2.47521711
71Severe visual impairment (HP:0001141)2.45160070
72Abnormality of serum amino acid levels (HP:0003112)2.44849109
73Recurrent gram-negative bacterial infections (HP:0005420)2.43453823
74Increased IgE level (HP:0003212)2.36841046
75Abnormality of the intrinsic pathway (HP:0010989)2.34404039
76Loss of speech (HP:0002371)2.34344761
77Orchitis (HP:0100796)2.33337216
78Delayed CNS myelination (HP:0002188)2.32926983
79Systemic lupus erythematosus (HP:0002725)2.32558710
80Cellulitis (HP:0100658)2.32151926
81Conjugated hyperbilirubinemia (HP:0002908)2.31297792
82Hypertensive crisis (HP:0100735)2.31265941
83Reduced antithrombin III activity (HP:0001976)2.29823975
84Hypochromic microcytic anemia (HP:0004840)2.29195376
85Generalized aminoaciduria (HP:0002909)2.28520771
86Renal cortical cysts (HP:0000803)2.27500996
87Vasculitis (HP:0002633)2.26156648
88J-shaped sella turcica (HP:0002680)2.25100671
89Stridor (HP:0010307)2.22012521
90Lymphopenia (HP:0001888)2.21968116
91Absent rod-and cone-mediated responses on ERG (HP:0007688)2.21931992
92Hypochromic anemia (HP:0001931)2.18865299
93Steatorrhea (HP:0002570)2.18443569
94Viral hepatitis (HP:0006562)2.18314548
95Metabolic acidosis (HP:0001942)2.18187590
96Spastic diplegia (HP:0001264)2.17285789
97Malnutrition (HP:0004395)2.16664366
98Hepatocellular carcinoma (HP:0001402)2.16295025
99Abnormality of iron homeostasis (HP:0011031)2.15899461
100Abnormality of cells of the lymphoid lineage (HP:0012140)2.14809829
101Abnormality of polysaccharide metabolism (HP:0011012)2.14512404
102Abnormality of glycosaminoglycan metabolism (HP:0004371)2.14512404
103Abnormality of mucopolysaccharide metabolism (HP:0011020)2.14512404
104Nausea (HP:0002018)2.14038686
105Gastrointestinal stroma tumor (HP:0100723)2.11339929
106Thoracic kyphosis (HP:0002942)2.09626622
107Abnormality of purine metabolism (HP:0004352)2.08526872
108Menorrhagia (HP:0000132)2.08395461
109Abnormality of transition element cation homeostasis (HP:0011030)2.08211659
110Gastrointestinal infarctions (HP:0005244)2.07919388
111Epistaxis (HP:0000421)2.07839916
112Albinism (HP:0001022)2.05117271
113Lethargy (HP:0001254)2.04990457
114Microretrognathia (HP:0000308)2.04286706
115Hepatosplenomegaly (HP:0001433)2.03018684
116Thrombocytosis (HP:0001894)2.02060027
117Increased serum ferritin (HP:0003281)2.01694649
118Prostate neoplasm (HP:0100787)2.01653925
119Chest pain (HP:0100749)2.01281425
120Osteomyelitis (HP:0002754)2.01238527
121Urticaria (HP:0001025)2.01104185
122Abnormal platelet volume (HP:0011876)1.99541210
123Seborrheic dermatitis (HP:0001051)1.98976758
124Opisthotonus (HP:0002179)1.97461470
125Polygenic inheritance (HP:0010982)1.97179022
126Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.95475919
127Vascular calcification (HP:0004934)1.95408826
128Microcytic anemia (HP:0001935)1.95246354
129Purpura (HP:0000979)1.94574138
130Glomerulonephritis (HP:0000099)1.93666844
131Spontaneous hematomas (HP:0007420)1.93606188
132Retrobulbar optic neuritis (HP:0100654)1.92097389
133Optic neuritis (HP:0100653)1.92097389
134Increased IgM level (HP:0003496)1.90447226
135Chromosomal breakage induced by crosslinking agents (HP:0003221)1.90247791
136Oral leukoplakia (HP:0002745)1.89777875
137Impaired platelet aggregation (HP:0003540)1.89386638
138Abnormal platelet function (HP:0011869)1.89386638
139Abnormal number of erythroid precursors (HP:0012131)1.89213323
140Abnormality of the prostate (HP:0008775)1.89169198
141Abnormality of small intestinal villus morphology (HP:0011472)1.88653170
142Villous atrophy (HP:0011473)1.88653170
143Hemoptysis (HP:0002105)1.88387185
144Prolonged bleeding time (HP:0003010)1.88205215
145Pulmonary infiltrates (HP:0002113)1.86011791
146Abnormality of cells of the erythroid lineage (HP:0012130)1.84701770
147Abnormality of T cell physiology (HP:0011840)1.84135557
148Acanthocytosis (HP:0001927)1.83987007
149Mucopolysacchariduria (HP:0008155)1.83576140
150Urinary glycosaminoglycan excretion (HP:0003541)1.83576140
151Proximal tubulopathy (HP:0000114)1.83367709
152Pancreatitis (HP:0001733)1.82703913
153Increased mean platelet volume (HP:0011877)1.82321809
154Thrombophlebitis (HP:0004418)1.82086053
155Cerebral palsy (HP:0100021)1.79549230
156Esophageal varix (HP:0002040)1.78882080
157Petechiae (HP:0000967)1.78577751
158Recurrent lower respiratory tract infections (HP:0002783)1.78191311
159Abnormality of reticulocytes (HP:0004312)1.77942627
160Abnormality of the thoracic spine (HP:0100711)1.77866106
161Aplasia/Hypoplasia of the sacrum (HP:0008517)1.77426272
162Poikiloderma (HP:0001029)1.77231046
163Vacuolated lymphocytes (HP:0001922)1.76681764
164Abnormal enzyme/coenzyme activity (HP:0012379)1.76212890
165Elevated hepatic transaminases (HP:0002910)1.74981619
166Gingivitis (HP:0000230)1.74956391
167Chromsome breakage (HP:0040012)1.74367899
168Hypertriglyceridemia (HP:0002155)1.74206682
169Poikilocytosis (HP:0004447)1.72807249
170Ketoacidosis (HP:0001993)1.72763858
171Gastrointestinal dysmotility (HP:0002579)1.69473071
172Prolonged neonatal jaundice (HP:0006579)1.68771142
173Abnormality of proline metabolism (HP:0010907)1.68676675
174Hydroxyprolinuria (HP:0003080)1.68676675
175Cheilitis (HP:0100825)1.68591446
176Recurrent bacterial skin infections (HP:0005406)1.68338550
177Verrucae (HP:0200043)1.67879687
178Papilloma (HP:0012740)1.67879687
179Cardiovascular calcification (HP:0011915)1.64585042
180Autoimmune thrombocytopenia (HP:0001973)1.63735270
181Abnormal cartilage morphology (HP:0002763)1.62577423
182Vomiting (HP:0002013)1.62199563

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SMG14.12640783
2BCKDK3.49459463
3VRK22.97674585
4ERN12.75429862
5MAP4K12.28010644
6MAP3K102.19561674
7FLT32.15189405
8TNK22.12965382
9FGFR42.03132807
10NME21.91113595
11STK161.73139064
12NEK21.71303334
13WEE11.70531261
14BLK1.70458949
15PRPF4B1.70120272
16TYK21.69965923
17MAP2K31.69375081
18RIPK41.68586424
19IRAK31.68568044
20KIT1.62708996
21TLK11.58247874
22FES1.55523507
23CDK71.52185744
24MAPK111.51903505
25ACVR1B1.51187764
26TAF11.50098674
27MAP3K111.44277729
28TBK11.43275496
29BUB11.40515146
30MST1R1.37905985
31TXK1.36376467
32EEF2K1.34386177
33PKN21.32465024
34CSF1R1.31366313
35IRAK41.30103105
36DYRK31.30065828
37MATK1.29827883
38TEC1.29489922
39EIF2AK11.29466862
40BTK1.29341854
41GRK61.28713230
42CSK1.28483277
43KDR1.28411586
44CDK41.27212691
45MAP3K141.26483763
46PIM11.26322088
47TAOK31.20869787
48SIK11.20339856
49PIM21.20248676
50RPS6KB21.16746416
51IKBKB1.15477495
52PRKD21.14863485
53STK101.13455462
54CDC71.10655790
55TAOK11.08308200
56TTK1.07491112
57HIPK21.04692073
58TGFBR11.03468104
59STK41.01242058
60RPS6KA41.00747802
61EPHA21.00721482
62ZAP700.99807006
63ATR0.98437288
64MAPK150.95856617
65MARK30.95854461
66IKBKE0.95548231
67TGFBR20.95063507
68CDK120.92774249
69ICK0.91640064
70NUAK10.90935225
71IRAK20.90517968
72JAK30.89292794
73MAPKAPK30.89278136
74AURKB0.88751920
75SIK30.88022156
76YES10.86233019
77CDK60.86123196
78ZAK0.86122009
79MAP3K60.84722249
80MAP3K30.84317915
81PLK10.83444408
82MAP3K80.82854034
83LYN0.80968597
84PTK60.78338780
85ADRBK20.77312615
86CDC42BPA0.77010212
87IRAK10.76479643
88ITK0.76024697
89DYRK1B0.74931712
90PAK40.73748019
91MAP2K20.72089387
92TIE10.71982305
93HCK0.71204258
94BMX0.71134352
95BRSK20.70794004
96TRIB30.67718249
97MAP2K60.67659912
98ABL20.66563121
99TESK20.64518341
100CHUK0.63965436
101DAPK10.63307344
102MAP3K10.62736103
103SRPK10.61293594
104NEK90.60745248
105PRKCI0.60091698
106TAOK20.60035733
107EIF2AK30.59877354
108CHEK20.58843115
109JAK20.58085855
110PIK3CG0.53726171
111PRKAA20.52125413
112NME10.51821775
113FGR0.50563118
114LRRK20.50501476
115VRK10.50049072
116EIF2AK20.49923371
117RPS6KA60.49730619
118PRKG20.49444142
119MAPKAPK20.48145381
120LCK0.46818152
121STK38L0.46815006
122CDK90.46180455
123MAPK40.45965057
124RPS6KA20.45751622
125PDPK10.45587558
126RPS6KC10.45298320
127RPS6KL10.45298320
128PLK40.45039216
129AURKA0.44588689
130PRKD30.44033377
131CSNK2A10.43864132
132SYK0.43831655
133PRKCQ0.42972870
134DAPK30.39855618
135PDK10.39001982
136FRK0.37174161
137CAMK1D0.35506096

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.10482481
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.94163509
3Asthma_Homo sapiens_hsa053102.58151755
4Pentose and glucuronate interconversions_Homo sapiens_hsa000402.53375666
5Allograft rejection_Homo sapiens_hsa053302.40005773
6Autoimmune thyroid disease_Homo sapiens_hsa053202.24183756
7DNA replication_Homo sapiens_hsa030302.22185823
8Graft-versus-host disease_Homo sapiens_hsa053322.20764363
9Tryptophan metabolism_Homo sapiens_hsa003802.17358690
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.10269400
11Arginine biosynthesis_Homo sapiens_hsa002202.06397817
12One carbon pool by folate_Homo sapiens_hsa006702.06223532
13Drug metabolism - other enzymes_Homo sapiens_hsa009832.00669139
14Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.99188057
15Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.95419875
16Fatty acid degradation_Homo sapiens_hsa000711.91912420
17Nitrogen metabolism_Homo sapiens_hsa009101.91456484
18Complement and coagulation cascades_Homo sapiens_hsa046101.89702190
19B cell receptor signaling pathway_Homo sapiens_hsa046621.83201723
20Folate biosynthesis_Homo sapiens_hsa007901.82812958
21Selenocompound metabolism_Homo sapiens_hsa004501.82790257
22Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.82473660
23Caffeine metabolism_Homo sapiens_hsa002321.78938740
24Osteoclast differentiation_Homo sapiens_hsa043801.76245472
25Antigen processing and presentation_Homo sapiens_hsa046121.76232491
26Lysosome_Homo sapiens_hsa041421.75704057
27Mismatch repair_Homo sapiens_hsa034301.74728030
28Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.71675476
29Sulfur relay system_Homo sapiens_hsa041221.71478964
30Peroxisome_Homo sapiens_hsa041461.65605088
31Staphylococcus aureus infection_Homo sapiens_hsa051501.61742892
32Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.59256065
33Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.58031124
34Histidine metabolism_Homo sapiens_hsa003401.57503953
35Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.56701298
36Type I diabetes mellitus_Homo sapiens_hsa049401.55979138
37Cyanoamino acid metabolism_Homo sapiens_hsa004601.54832269
38Chemical carcinogenesis_Homo sapiens_hsa052041.54384968
39Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.52918872
40Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.48294885
41beta-Alanine metabolism_Homo sapiens_hsa004101.46243613
42Base excision repair_Homo sapiens_hsa034101.45016205
43Tuberculosis_Homo sapiens_hsa051521.45014513
44Steroid hormone biosynthesis_Homo sapiens_hsa001401.44686879
45Retinol metabolism_Homo sapiens_hsa008301.39647470
46Acute myeloid leukemia_Homo sapiens_hsa052211.39520514
47Hematopoietic cell lineage_Homo sapiens_hsa046401.39346676
48Ribosome_Homo sapiens_hsa030101.37835556
49Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.37409817
502-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.36303769
51Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.36286717
52Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.35886450
53Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.33013232
54Toll-like receptor signaling pathway_Homo sapiens_hsa046201.30693631
55Biosynthesis of amino acids_Homo sapiens_hsa012301.25428804
56Propanoate metabolism_Homo sapiens_hsa006401.25018675
57PPAR signaling pathway_Homo sapiens_hsa033201.22368070
58Cysteine and methionine metabolism_Homo sapiens_hsa002701.21039727
59Starch and sucrose metabolism_Homo sapiens_hsa005001.20499439
60Fatty acid metabolism_Homo sapiens_hsa012121.16787726
61Homologous recombination_Homo sapiens_hsa034401.11935952
62Pentose phosphate pathway_Homo sapiens_hsa000301.09244438
63Carbon metabolism_Homo sapiens_hsa012001.08855894
64Vitamin digestion and absorption_Homo sapiens_hsa049771.08487140
65Arginine and proline metabolism_Homo sapiens_hsa003301.07752663
66Fat digestion and absorption_Homo sapiens_hsa049751.07402680
67Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.06557745
68Butanoate metabolism_Homo sapiens_hsa006501.06545257
69Rheumatoid arthritis_Homo sapiens_hsa053231.06451474
70Influenza A_Homo sapiens_hsa051641.06427045
71NOD-like receptor signaling pathway_Homo sapiens_hsa046211.05151889
72Glutathione metabolism_Homo sapiens_hsa004801.04062961
73ABC transporters_Homo sapiens_hsa020101.02906596
74Toxoplasmosis_Homo sapiens_hsa051450.98282350
75Lysine degradation_Homo sapiens_hsa003100.96910717
76Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.95707617
77Pyrimidine metabolism_Homo sapiens_hsa002400.94588734
78Phenylalanine metabolism_Homo sapiens_hsa003600.94503990
79Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.93887981
80Pyruvate metabolism_Homo sapiens_hsa006200.91672063
81T cell receptor signaling pathway_Homo sapiens_hsa046600.89710857
82Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.89062461
83Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.88720018
84Glycerophospholipid metabolism_Homo sapiens_hsa005640.86652129
85TNF signaling pathway_Homo sapiens_hsa046680.86466157
86Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.85502484
87Hepatitis C_Homo sapiens_hsa051600.84063924
88Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.84030181
89Nucleotide excision repair_Homo sapiens_hsa034200.84004401
90Viral myocarditis_Homo sapiens_hsa054160.83911052
91Tyrosine metabolism_Homo sapiens_hsa003500.82189449
92Epstein-Barr virus infection_Homo sapiens_hsa051690.81546776
93Sulfur metabolism_Homo sapiens_hsa009200.78636267
94Fructose and mannose metabolism_Homo sapiens_hsa000510.77822785
95Notch signaling pathway_Homo sapiens_hsa043300.76801283
96Fatty acid elongation_Homo sapiens_hsa000620.75381599
97Maturity onset diabetes of the young_Homo sapiens_hsa049500.75108418
98Bile secretion_Homo sapiens_hsa049760.74541030
99Galactose metabolism_Homo sapiens_hsa000520.74493854
100Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.72464543
101Jak-STAT signaling pathway_Homo sapiens_hsa046300.72401294
102alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.72207260
103Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.71923757
104Hepatitis B_Homo sapiens_hsa051610.69447407
105N-Glycan biosynthesis_Homo sapiens_hsa005100.69295438
106HTLV-I infection_Homo sapiens_hsa051660.69035421
107Bladder cancer_Homo sapiens_hsa052190.68654086
108Fanconi anemia pathway_Homo sapiens_hsa034600.67320748
109Apoptosis_Homo sapiens_hsa042100.66999179
110Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.66912425
111Pertussis_Homo sapiens_hsa051330.62524749
112Spliceosome_Homo sapiens_hsa030400.61907405
113Viral carcinogenesis_Homo sapiens_hsa052030.60045550
114Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.57286835
115Steroid biosynthesis_Homo sapiens_hsa001000.57100034
116Glycosaminoglycan degradation_Homo sapiens_hsa005310.56710510
117Transcriptional misregulation in cancer_Homo sapiens_hsa052020.55842685
118Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.55696479
119Other glycan degradation_Homo sapiens_hsa005110.55376821
120Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.52444600
121Metabolic pathways_Homo sapiens_hsa011000.52165280
122Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.51646091
123Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.50108098
124Herpes simplex infection_Homo sapiens_hsa051680.49514991
125Non-small cell lung cancer_Homo sapiens_hsa052230.49511453
126Chemokine signaling pathway_Homo sapiens_hsa040620.49382930
127Malaria_Homo sapiens_hsa051440.49204798
128Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.49187258
129Systemic lupus erythematosus_Homo sapiens_hsa053220.49081494
130Vitamin B6 metabolism_Homo sapiens_hsa007500.48514549
131Primary immunodeficiency_Homo sapiens_hsa053400.47415993
132RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.46264066
133Proteasome_Homo sapiens_hsa030500.45596838
134NF-kappa B signaling pathway_Homo sapiens_hsa040640.45490276
135Sphingolipid metabolism_Homo sapiens_hsa006000.45377230
136Legionellosis_Homo sapiens_hsa051340.43663363
137Phagosome_Homo sapiens_hsa041450.43318453
138Collecting duct acid secretion_Homo sapiens_hsa049660.43119871
139Chronic myeloid leukemia_Homo sapiens_hsa052200.42981181
140Non-homologous end-joining_Homo sapiens_hsa034500.42687322
141African trypanosomiasis_Homo sapiens_hsa051430.41604722
142Glycerolipid metabolism_Homo sapiens_hsa005610.40659929
143Ether lipid metabolism_Homo sapiens_hsa005650.40079359
144Cell cycle_Homo sapiens_hsa041100.40036601
145Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.39965147
146Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.38804456
147RNA transport_Homo sapiens_hsa030130.38517618
148Intestinal immune network for IgA production_Homo sapiens_hsa046720.37637074
149Platelet activation_Homo sapiens_hsa046110.36952578
150Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.36948088
151Insulin resistance_Homo sapiens_hsa049310.36225106
152Adipocytokine signaling pathway_Homo sapiens_hsa049200.35833642
153p53 signaling pathway_Homo sapiens_hsa041150.35790753
154RNA polymerase_Homo sapiens_hsa030200.34695155
155Sphingolipid signaling pathway_Homo sapiens_hsa040710.34417509
156Measles_Homo sapiens_hsa051620.26368826
157Renin-angiotensin system_Homo sapiens_hsa046140.25492889
158Leishmaniasis_Homo sapiens_hsa051400.24249977
159Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.23907074
160Arachidonic acid metabolism_Homo sapiens_hsa005900.21373223

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