AKR7A2P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)6.63545799
2nuclear pore organization (GO:0006999)5.80260867
3atrioventricular valve morphogenesis (GO:0003181)5.68312766
4DNA replication checkpoint (GO:0000076)4.85416371
5positive regulation of transcription from RNA polymerase III promoter (GO:0045945)4.77519446
6pore complex assembly (GO:0046931)4.71760137
7DNA duplex unwinding (GO:0032508)4.64227235
8DNA unwinding involved in DNA replication (GO:0006268)4.55151654
9DNA replication initiation (GO:0006270)4.50289154
10DNA geometric change (GO:0032392)4.45987195
11DNA strand elongation (GO:0022616)4.28279324
12DNA strand elongation involved in DNA replication (GO:0006271)4.27409052
13regulation of DNA damage checkpoint (GO:2000001)4.19691890
14regulation of RNA export from nucleus (GO:0046831)4.19607665
15homocysteine metabolic process (GO:0050667)4.16965024
16positive regulation of osteoblast proliferation (GO:0033690)4.08030149
17regulation of centriole replication (GO:0046599)4.05512128
18mitochondrial DNA metabolic process (GO:0032042)4.03248558
19regulation of translational fidelity (GO:0006450)4.02283353
20mitotic chromosome condensation (GO:0007076)3.95857854
21cellular protein complex localization (GO:0034629)3.93919097
22telomere maintenance via semi-conservative replication (GO:0032201)3.91953334
23L-serine metabolic process (GO:0006563)3.82628816
24telomere maintenance via recombination (GO:0000722)3.80120635
25mitotic sister chromatid segregation (GO:0000070)3.79465906
26pre-miRNA processing (GO:0031054)3.76465987
27DNA synthesis involved in DNA repair (GO:0000731)3.75931766
28glutamine metabolic process (GO:0006541)3.71477943
29TOR signaling (GO:0031929)3.65507204
30sister chromatid segregation (GO:0000819)3.54000393
31DNA conformation change (GO:0071103)3.52004841
32cell migration involved in sprouting angiogenesis (GO:0002042)3.50209019
33protein complex localization (GO:0031503)3.49025904
34mitotic sister chromatid cohesion (GO:0007064)3.44530111
35negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.42123408
36negative regulation of histone methylation (GO:0031061)3.38870603
37mitotic nuclear envelope disassembly (GO:0007077)3.38224127
38mitotic recombination (GO:0006312)3.37274169
39regulation of centrosome duplication (GO:0010824)3.36612151
40DNA topological change (GO:0006265)3.34859069
41regulation of nucleobase-containing compound transport (GO:0032239)3.32105108
42tRNA methylation (GO:0030488)3.31139912
43urea cycle (GO:0000050)3.27259433
44regulation of cell proliferation involved in kidney development (GO:1901722)3.24724960
45membrane disassembly (GO:0030397)3.22870733
46nuclear envelope disassembly (GO:0051081)3.22870733
47nitrogen cycle metabolic process (GO:0071941)3.17651940
48negative regulation of mRNA metabolic process (GO:1903312)3.17524756
49regulation of cell cycle checkpoint (GO:1901976)3.16417562
50regulation of histone H3-K9 methylation (GO:0051570)3.15037476
51viral mRNA export from host cell nucleus (GO:0046784)3.14506309
52positive regulation of cell cycle checkpoint (GO:1901978)3.13288767
53glucocorticoid receptor signaling pathway (GO:0042921)3.12170635
54apoptotic process involved in morphogenesis (GO:0060561)3.11274245
55heterochromatin organization (GO:0070828)3.10962086
56regulation of centrosome cycle (GO:0046605)3.10295634
57L-alpha-amino acid transmembrane transport (GO:1902475)3.08900370
58nucleotide-excision repair, DNA gap filling (GO:0006297)3.06060477
59regulation of hippo signaling (GO:0035330)3.01445194
60DNA biosynthetic process (GO:0071897)3.01072683
61midgut development (GO:0007494)3.00351654
62peptidyl-lysine dimethylation (GO:0018027)2.98373110
63blood vessel endothelial cell migration (GO:0043534)2.97665876
64atrial septum morphogenesis (GO:0060413)2.97571566
65negative regulation of cell cycle G2/M phase transition (GO:1902750)2.96136100
66DNA replication-dependent nucleosome assembly (GO:0006335)2.95552659
67DNA replication-dependent nucleosome organization (GO:0034723)2.95552659
68negative regulation of mRNA processing (GO:0050686)2.92707654
69pericardium development (GO:0060039)2.89058454
70negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)2.89047046
71formation of translation preinitiation complex (GO:0001731)2.88615880
72protein-DNA complex disassembly (GO:0032986)2.87340944
73nucleosome disassembly (GO:0006337)2.87340944
74non-recombinational repair (GO:0000726)2.87280841
75double-strand break repair via nonhomologous end joining (GO:0006303)2.87280841
76folic acid metabolic process (GO:0046655)2.87138421
77corticosteroid receptor signaling pathway (GO:0031958)2.85849626
78nuclear envelope organization (GO:0006998)2.85566852
79positive regulation of p38MAPK cascade (GO:1900745)2.85559211
80urea metabolic process (GO:0019627)2.85270522
81ribosome biogenesis (GO:0042254)2.85185646
82translesion synthesis (GO:0019985)2.84553857
83spliceosomal tri-snRNP complex assembly (GO:0000244)2.84510746
84histone arginine methylation (GO:0034969)2.81506327
85positive regulation of odontogenesis (GO:0042482)2.81331612
86regulation of NFAT protein import into nucleus (GO:0051532)2.81208593
87dosage compensation (GO:0007549)2.80506486
88regulation of monocyte differentiation (GO:0045655)2.79982614
89positive regulation by host of viral transcription (GO:0043923)2.78894482
90peptidyl-arginine omega-N-methylation (GO:0035247)2.77591219
91telomere maintenance (GO:0000723)2.76742991
92low-density lipoprotein particle clearance (GO:0034383)2.76221963
93telomere organization (GO:0032200)2.74383169
94rRNA transcription (GO:0009303)2.73102173
95meiotic chromosome segregation (GO:0045132)2.72728262
96mitochondrial RNA metabolic process (GO:0000959)2.72058894
97monoubiquitinated protein deubiquitination (GO:0035520)2.69564317
98dorsal/ventral axis specification (GO:0009950)2.68657655
99protein localization to chromosome, centromeric region (GO:0071459)2.66503661
100regulation of spindle checkpoint (GO:0090231)2.66416364

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.68818992
2FOXM1_23109430_ChIP-Seq_U2OS_Human3.93454302
3STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse3.56782661
4BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.38226386
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.29474258
6MYC_18555785_ChIP-Seq_MESCs_Mouse3.27104453
7MYC_22102868_ChIP-Seq_BL_Human2.92583521
8ZNF263_19887448_ChIP-Seq_K562_Human2.92174055
9FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.55884337
10E2F1_21310950_ChIP-Seq_MCF-7_Human2.40369226
11EGR1_19374776_ChIP-ChIP_THP-1_Human2.36874244
12HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.27753233
13MYC_19030024_ChIP-ChIP_MESCs_Mouse2.12276009
14NOTCH1_21737748_ChIP-Seq_TLL_Human2.10976872
15KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.02789679
16E2F7_22180533_ChIP-Seq_HELA_Human10.1677344
17MYC_19079543_ChIP-ChIP_MESCs_Mouse1.97013239
18EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.96996511
19DCP1A_22483619_ChIP-Seq_HELA_Human1.87880586
20POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.86285511
21GATA1_22025678_ChIP-Seq_K562_Human1.85980911
22DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.78493888
23NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.70800026
24TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.70294662
25YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.70009215
26NELFA_20434984_ChIP-Seq_ESCs_Mouse1.68772796
27MYC_18358816_ChIP-ChIP_MESCs_Mouse1.65154911
28KDM5A_27292631_Chip-Seq_BREAST_Human1.64732542
29PKCTHETA_26484144_Chip-Seq_BREAST_Human1.62655134
30AR_21909140_ChIP-Seq_LNCAP_Human1.62285247
31VDR_21846776_ChIP-Seq_THP-1_Human1.61253305
32CIITA_25753668_ChIP-Seq_RAJI_Human1.55092308
33KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.54254429
34XRN2_22483619_ChIP-Seq_HELA_Human1.53185731
35CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.52786229
36TP63_17297297_ChIP-ChIP_HaCaT_Human1.51248194
37HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.49584987
38CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.47994752
39MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.45301520
40MYCN_18555785_ChIP-Seq_MESCs_Mouse1.43154315
41THAP11_20581084_ChIP-Seq_MESCs_Mouse1.40111316
42TTF2_22483619_ChIP-Seq_HELA_Human1.36688466
43JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.31594024
44TCF7_22412390_ChIP-Seq_EML_Mouse1.26422147
45TFEB_21752829_ChIP-Seq_HELA_Human1.25422753
46SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.21248838
47KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.20711056
48E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.18824013
49CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.18481001
50ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.18197943
51CLOCK_20551151_ChIP-Seq_293T_Human1.17585221
52DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.16150764
53KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.15368391
54ZFX_18555785_ChIP-Seq_MESCs_Mouse1.13362863
55EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.12531902
56CREB1_15753290_ChIP-ChIP_HEK293T_Human1.10851613
57CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.10787014
58NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.08932254
59STAT3_1855785_ChIP-Seq_MESCs_Mouse1.08598248
60EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.07520073
61ATF3_27146783_Chip-Seq_COLON_Human1.05586296
62UBF1/2_26484160_Chip-Seq_HMECs_Human1.04318662
63P300_27058665_Chip-Seq_ZR-75-30cells_Human1.04058239
64BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.03361927
65E2F1_18555785_ChIP-Seq_MESCs_Mouse1.03131637
66KDM2B_26808549_Chip-Seq_SUP-B15_Human1.01937387
67ELK3_25401928_ChIP-Seq_HUVEC_Human1.01312565
68NCOR1_26117541_ChIP-Seq_K562_Human1.01043193
69KDM2B_26808549_Chip-Seq_DND41_Human1.00758865
70RACK7_27058665_Chip-Seq_MCF-7_Human1.00742166
71MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.99790904
72CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.98576961
73ETS1_20019798_ChIP-Seq_JURKAT_Human0.97678435
74PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.97657176
75ERG_20887958_ChIP-Seq_HPC-7_Mouse0.97395026
76NANOG_18555785_ChIP-Seq_MESCs_Mouse0.97121594
77KLF4_18555785_ChIP-Seq_MESCs_Mouse0.96394205
78GABP_19822575_ChIP-Seq_HepG2_Human0.94907992
79CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.94474791
80CHD1_26751641_Chip-Seq_LNCaP_Human0.94093721
81TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.92180198
82TP63_19390658_ChIP-ChIP_HaCaT_Human0.92085118
83PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.91720875
84CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.91622514
85KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.90313640
86TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.89912226
87PADI4_21655091_ChIP-ChIP_MCF-7_Human0.89794635
88FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.88944404
89KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.87052822
90SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.86847903
91SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.86768868
92SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.86768868
93ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.86072936
94FOXP3_21729870_ChIP-Seq_TREG_Human0.84044943
95KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.83938629
96MAF_26560356_Chip-Seq_TH1_Human0.83607644
97RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.81731136
98FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.81506176
99GATA6_25053715_ChIP-Seq_YYC3_Human0.80912439
100TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.79818769

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005083_abnormal_biliary_tract6.57680533
2MP0010094_abnormal_chromosome_stability4.11897409
3MP0008057_abnormal_DNA_replication3.93206942
4MP0003111_abnormal_nucleus_morphology3.74636025
5MP0005076_abnormal_cell_differentiation3.57700603
6MP0004233_abnormal_muscle_weight3.41487314
7MP0002396_abnormal_hematopoietic_system2.92616911
8MP0003693_abnormal_embryo_hatching2.88922540
9MP0003077_abnormal_cell_cycle2.85294004
10MP0008058_abnormal_DNA_repair2.57701689
11MP0004808_abnormal_hematopoietic_stem2.53828017
12MP0004957_abnormal_blastocyst_morpholog2.51784358
13MP0008932_abnormal_embryonic_tissue2.16186578
14MP0002089_abnormal_postnatal_growth/wei2.13553981
15MP0002009_preneoplasia2.10315944
16MP0005220_abnormal_exocrine_pancreas2.07037719
17MP0010307_abnormal_tumor_latency2.05896599
18MP0003705_abnormal_hypodermis_morpholog1.88035917
19MP0010352_gastrointestinal_tract_polyps1.84889625
20MP0001661_extended_life_span1.81359158
21MP0003984_embryonic_growth_retardation1.80709363
22MP0003786_premature_aging1.79020401
23MP0000003_abnormal_adipose_tissue1.77830629
24MP0001730_embryonic_growth_arrest1.75294533
25MP0002088_abnormal_embryonic_growth/wei1.73364130
26MP0000350_abnormal_cell_proliferation1.71397734
27MP0008007_abnormal_cellular_replicative1.62425540
28MP0005380_embryogenesis_phenotype1.62357437
29MP0001672_abnormal_embryogenesis/_devel1.62357437
30MP0009672_abnormal_birth_weight1.54032675
31MP0002697_abnormal_eye_size1.51582037
32MP0002086_abnormal_extraembryonic_tissu1.49817552
33MP0002938_white_spotting1.49689843
34MP0002080_prenatal_lethality1.38964358
35MP0002084_abnormal_developmental_patter1.37817478
36MP0001697_abnormal_embryo_size1.34768584
37MP0003566_abnormal_cell_adhesion1.34274449
38MP0003937_abnormal_limbs/digits/tail_de1.28761148
39MP0000579_abnormal_nail_morphology1.28020569
40MP0004197_abnormal_fetal_growth/weight/1.23804243
41MP0002108_abnormal_muscle_morphology1.23674527
42MP0009278_abnormal_bone_marrow1.23523669
43MP0009840_abnormal_foam_cell1.23134116
44MP0003890_abnormal_embryonic-extraembry1.17565072
45MP0005197_abnormal_uvea_morphology1.16701465
46MP0000313_abnormal_cell_death1.15289737
47MP0002111_abnormal_tail_morphology1.14184314
48MP0002085_abnormal_embryonic_tissue1.09921211
49MP0005621_abnormal_cell_physiology1.09803603
50MP0001849_ear_inflammation1.08658630
51MP0002877_abnormal_melanocyte_morpholog1.07773604
52MP0003959_abnormal_lean_body1.07441106
53MP0000733_abnormal_muscle_development1.07289696
54MP0000537_abnormal_urethra_morphology1.06333663
55MP0009703_decreased_birth_body1.01238817
56MP0000013_abnormal_adipose_tissue0.98067771
57MP0003718_maternal_effect0.96402345
58MP0003453_abnormal_keratinocyte_physiol0.93884054
59MP0000490_abnormal_crypts_of0.91187638
60MP0009697_abnormal_copulation0.90781463
61MP0002332_abnormal_exercise_endurance0.89994856
62MP0002269_muscular_atrophy0.89335344
63MP0000428_abnormal_craniofacial_morphol0.88558279
64MP0005384_cellular_phenotype0.88395785
65MP0002970_abnormal_white_adipose0.86630040
66MP0000383_abnormal_hair_follicle0.84803416
67MP0003567_abnormal_fetal_cardiomyocyte0.84770253
68MP0010030_abnormal_orbit_morphology0.84433702
69MP0008770_decreased_survivor_rate0.84308220
70MP0004185_abnormal_adipocyte_glucose0.83238311
71MP0002019_abnormal_tumor_incidence0.82044643
72MP0000358_abnormal_cell_content/0.81783005
73MP0010630_abnormal_cardiac_muscle0.79413833
74MP0008961_abnormal_basal_metabolism0.79048706
75MP0005375_adipose_tissue_phenotype0.78754508
76MP0003763_abnormal_thymus_physiology0.77855804
77MP0005501_abnormal_skin_physiology0.77656197
78MP0006138_congestive_heart_failure0.76891296
79MP0000759_abnormal_skeletal_muscle0.75563284
80MP0008995_early_reproductive_senescence0.74038303
81MP0002092_abnormal_eye_morphology0.73747239
82MP0003950_abnormal_plasma_membrane0.71648834
83MP0001286_abnormal_eye_development0.70926578
84MP0004087_abnormal_muscle_fiber0.70901598
85MP0003091_abnormal_cell_migration0.70200426
86MP0003699_abnormal_female_reproductive0.68833754
87MP0000049_abnormal_middle_ear0.67377549
88MP0000432_abnormal_head_morphology0.65540076
89MP0003115_abnormal_respiratory_system0.64650177
90MP0010678_abnormal_skin_adnexa0.64238209
91MP0002060_abnormal_skin_morphology0.64145414
92MP0005334_abnormal_fat_pad0.63704208
93MP0000598_abnormal_liver_morphology0.61487996
94MP0002796_impaired_skin_barrier0.58388934
95MP0002925_abnormal_cardiovascular_devel0.58033658
96MP0001348_abnormal_lacrimal_gland0.57963538
97MP0006035_abnormal_mitochondrial_morpho0.57880656
98MP0003935_abnormal_craniofacial_develop0.57406851
99MP0003941_abnormal_skin_development0.56621055
100MP0001243_abnormal_dermal_layer0.56381705

Predicted human phenotypes

RankGene SetZ-score
1Microvesicular hepatic steatosis (HP:0001414)4.67398992
2Chromosomal breakage induced by crosslinking agents (HP:0003221)4.38648168
3Progressive muscle weakness (HP:0003323)4.09685097
4Chromsome breakage (HP:0040012)3.82616416
5Dysmetric saccades (HP:0000641)3.59643887
6Abnormality of the nasal septum (HP:0000419)3.36349447
7Broad face (HP:0000283)3.03786547
8Duplicated collecting system (HP:0000081)2.96972811
9Central scotoma (HP:0000603)2.92050998
10Lip pit (HP:0100267)2.89740732
11Urethral obstruction (HP:0000796)2.89442673
12Progressive external ophthalmoplegia (HP:0000590)2.78170359
13Depressed nasal tip (HP:0000437)2.77005664
14Ragged-red muscle fibers (HP:0003200)2.76166961
15Homocystinuria (HP:0002156)2.74373661
16Abnormality of homocysteine metabolism (HP:0010919)2.74373661
17Birth length less than 3rd percentile (HP:0003561)2.72048614
18Ulnar bowing (HP:0003031)2.67496316
19Ectopic kidney (HP:0000086)2.61626527
20Breast hypoplasia (HP:0003187)2.61435013
21Ankyloglossia (HP:0010296)2.52731406
22Abnormality of the fingertips (HP:0001211)2.45286285
23Sandal gap (HP:0001852)2.44372862
24Abnormality of cochlea (HP:0000375)2.43792790
25Abnormality of the calcaneus (HP:0008364)2.42898377
26Aplasia cutis congenita (HP:0001057)2.42414663
27Abnormality of the distal phalanx of the thumb (HP:0009617)2.41439967
28Absent radius (HP:0003974)2.40103447
29Hyperacusis (HP:0010780)2.39965216
30Duplication of thumb phalanx (HP:0009942)2.36892780
31Abnormality of the renal collecting system (HP:0004742)2.33712521
32Calcaneovalgus deformity (HP:0001848)2.32719655
33Deviation of the thumb (HP:0009603)2.32408178
34Long eyelashes (HP:0000527)2.29708688
35Prominent nose (HP:0000448)2.29020619
36Sparse lateral eyebrow (HP:0005338)2.27750786
37Aplasia of the musculature (HP:0100854)2.22399364
38Sensory axonal neuropathy (HP:0003390)2.22380985
39Aplasia/Hypoplasia of the uvula (HP:0010293)2.21828571
40Abnormality of DNA repair (HP:0003254)2.18659701
41Absent forearm bone (HP:0003953)2.17941099
42Aplasia involving forearm bones (HP:0009822)2.17941099
43Squamous cell carcinoma (HP:0002860)2.16418479
44Ureteral duplication (HP:0000073)2.12932081
45Short thumb (HP:0009778)2.11058596
46Abnormality of oral frenula (HP:0000190)2.10212685
47Cerebellar dysplasia (HP:0007033)2.10188809
48Thin ribs (HP:0000883)2.06008940
49Scotoma (HP:0000575)2.02604641
50Proximal placement of thumb (HP:0009623)2.02205404
51Abnormality of chromosome stability (HP:0003220)2.00876190
52Meckel diverticulum (HP:0002245)1.99924971
53Abnormality of the ileum (HP:0001549)1.99817618
54Abnormality of the carotid arteries (HP:0005344)1.97766949
55Abnormality of the preputium (HP:0100587)1.97686396
56Intestinal fistula (HP:0100819)1.97332119
57Anal stenosis (HP:0002025)1.97165870
58Hypergonadotropic hypogonadism (HP:0000815)1.94925188
59Patellar aplasia (HP:0006443)1.94640483
60Abnormal number of incisors (HP:0011064)1.92097710
61Milia (HP:0001056)1.91477190
62Multiple enchondromatosis (HP:0005701)1.91401386
63Nasolacrimal duct obstruction (HP:0000579)1.87767470
64Elbow flexion contracture (HP:0002987)1.87131731
652-3 toe syndactyly (HP:0004691)1.86288447
66Premature ovarian failure (HP:0008209)1.86062056
67Persistence of primary teeth (HP:0006335)1.85601141
68Deformed tarsal bones (HP:0008119)1.83783175
69Natal tooth (HP:0000695)1.82219256
70Fair hair (HP:0002286)1.82170611
71Deep philtrum (HP:0002002)1.81228936
72Impulsivity (HP:0100710)1.80034530
73Abnormality of the salivary glands (HP:0010286)1.79034059
74Nephroblastoma (Wilms tumor) (HP:0002667)1.77467819
75Distal lower limb amyotrophy (HP:0008944)1.76716169
76Selective tooth agenesis (HP:0001592)1.75778976
77Esophageal atresia (HP:0002032)1.75623525
78Aplasia/Hypoplasia of the patella (HP:0006498)1.74282421
79Long palpebral fissure (HP:0000637)1.74238240
80Clubbing of toes (HP:0100760)1.72779179
81Dislocated radial head (HP:0003083)1.72144335
82Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.71783265
83Aplasia/Hypoplasia involving the musculature (HP:0001460)1.69833818
84Epidermoid cyst (HP:0200040)1.69801107
85Sloping forehead (HP:0000340)1.69567838
86Dyschromatopsia (HP:0007641)1.68698845
87Intestinal malrotation (HP:0002566)1.68164110
88Subcapsular cataract (HP:0000523)1.66446249
89Reticulocytopenia (HP:0001896)1.66001301
90Spina bifida occulta (HP:0003298)1.65732265
91Increased connective tissue (HP:0009025)1.65621030
92Cutis marmorata (HP:0000965)1.63546194
93Preauricular skin tag (HP:0000384)1.63189252
94Short chin (HP:0000331)1.62042879
95Small intestinal stenosis (HP:0012848)1.61817585
96Duodenal stenosis (HP:0100867)1.61817585
97Abnormality of pyrimidine metabolism (HP:0004353)1.61636163
98External ophthalmoplegia (HP:0000544)1.60135111
99Abnormality of the lacrimal duct (HP:0011481)1.59635244
100Relative macrocephaly (HP:0004482)1.58310106

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PIM25.97564169
2ICK4.94845665
3CDK124.64891344
4PDK24.43458935
5RAF13.18643245
6TLK12.84816236
7EEF2K2.84481448
8CDC72.82736405
9ZAK2.33079391
10BRD42.22058935
11MTOR2.12613242
12MAP3K102.09103642
13SMG12.02113957
14CAMK1D1.86333703
15PIM11.84957906
16MAPK111.80534590
17TRIB31.80392896
18SRPK11.65386916
19MST1R1.59376779
20PAK21.50593970
21NME11.40527229
22MAP3K71.38038621
23RPS6KA51.35814790
24TTN1.32969212
25CAMK1G1.32809825
26AKT31.29290649
27TTK1.22250234
28CHEK21.21070701
29PBK1.20793426
30MKNK21.16166366
31NEK61.11816333
32RPS6KB21.11074212
33MET0.98464612
34ATR0.97846878
35CHEK10.97598371
36AURKB0.96687607
37LATS20.94880717
38STK390.93491743
39AURKA0.91495028
40MKNK10.90197488
41WNK40.88405748
42PRPF4B0.84521506
43CDK70.84128173
44BUB10.83869993
45PRKAA10.82711962
46RPS6KA10.78589907
47CDK40.77437221
48LATS10.75802086
49CDK20.67952886
50RPS6KC10.66152988
51RPS6KL10.66152988
52TSSK60.65417473
53EPHA20.65246287
54ACVR1B0.64086481
55MAP3K80.59670479
56GSK3A0.59309498
57PLK10.58940614
58BRSK20.58605188
59SCYL20.55428902
60VRK10.55402782
61ATM0.54874888
62MELK0.53763290
63RPS6KA60.53700895
64CDK80.53565451
65CDK60.52561769
66CDK10.52391687
67MARK20.46937007
68NEK20.46512424
69GSK3B0.46024294
70MAPK140.45668718
71MAPK100.45037634
72MAPK10.42734936
73PASK0.42672306
74NME20.42397880
75MAP2K20.40612309
76BMX0.40430630
77MAPK120.40247078
78PKN20.37252376
79CDK90.37040289
80TRPM70.36374312
81AKT10.35624998
82ERBB40.35584430
83IRAK30.35533766
84MAP2K30.35490158
85WEE10.31848018
86TAOK20.31720719
87PTK20.30835139
88SIK10.30504807
89MAPK70.30425875
90OXSR10.30356371
91PRKDC0.30178460
92TGFBR10.29504799
93BMPR1B0.28809690
94MAPK90.28416151
95MAPK80.27435831
96PRKAA20.27211263
97CSNK1A1L0.27164862
98PLK40.26133169
99STK40.24251596
100MAPK30.24149328

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.16350615
2Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009703.40215484
3Systemic lupus erythematosus_Homo sapiens_hsa053223.32777978
4Vitamin B6 metabolism_Homo sapiens_hsa007502.73355241
5Non-homologous end-joining_Homo sapiens_hsa034502.54412363
6Cell cycle_Homo sapiens_hsa041102.52593282
7Mismatch repair_Homo sapiens_hsa034302.48192101
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.40983058
9Base excision repair_Homo sapiens_hsa034102.40223620
10Fanconi anemia pathway_Homo sapiens_hsa034602.39953101
11Alcoholism_Homo sapiens_hsa050342.33181086
12Homologous recombination_Homo sapiens_hsa034402.19403165
13Thyroid cancer_Homo sapiens_hsa052162.16844138
14One carbon pool by folate_Homo sapiens_hsa006702.02760165
15RNA transport_Homo sapiens_hsa030132.01614808
16mRNA surveillance pathway_Homo sapiens_hsa030152.01119898
17Small cell lung cancer_Homo sapiens_hsa052222.00405971
18Biosynthesis of amino acids_Homo sapiens_hsa012301.95650761
19Nucleotide excision repair_Homo sapiens_hsa034201.86257645
20Lysine degradation_Homo sapiens_hsa003101.81995745
21Bladder cancer_Homo sapiens_hsa052191.75204828
22Spliceosome_Homo sapiens_hsa030401.73112618
23MicroRNAs in cancer_Homo sapiens_hsa052061.67047216
24Viral carcinogenesis_Homo sapiens_hsa052031.66166500
25Central carbon metabolism in cancer_Homo sapiens_hsa052301.59585412
26Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.57850951
27RNA polymerase_Homo sapiens_hsa030201.53800700
28Chronic myeloid leukemia_Homo sapiens_hsa052201.49608614
29Fructose and mannose metabolism_Homo sapiens_hsa000511.44578223
30TGF-beta signaling pathway_Homo sapiens_hsa043501.41081936
31Selenocompound metabolism_Homo sapiens_hsa004501.39835439
32Pyrimidine metabolism_Homo sapiens_hsa002401.32613376
33Arginine biosynthesis_Homo sapiens_hsa002201.30951841
34Sulfur relay system_Homo sapiens_hsa041221.05716057
35Endometrial cancer_Homo sapiens_hsa052131.05607906
36Cysteine and methionine metabolism_Homo sapiens_hsa002701.05512082
37Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.04391738
38Other glycan degradation_Homo sapiens_hsa005111.03920357
39Acute myeloid leukemia_Homo sapiens_hsa052211.03835491
40Colorectal cancer_Homo sapiens_hsa052101.03065010
41Transcriptional misregulation in cancer_Homo sapiens_hsa052021.00525689
42Adherens junction_Homo sapiens_hsa045200.97809470
43Longevity regulating pathway - mammal_Homo sapiens_hsa042110.92266537
44mTOR signaling pathway_Homo sapiens_hsa041500.91688866
45Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.90174244
46Hippo signaling pathway_Homo sapiens_hsa043900.89577483
47Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.89477542
48Pentose phosphate pathway_Homo sapiens_hsa000300.87192481
49p53 signaling pathway_Homo sapiens_hsa041150.85649406
50Thyroid hormone signaling pathway_Homo sapiens_hsa049190.83494633
51RNA degradation_Homo sapiens_hsa030180.81504528
52Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.80980817
53Purine metabolism_Homo sapiens_hsa002300.80154142
54HTLV-I infection_Homo sapiens_hsa051660.77502471
55Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.77400756
56Cyanoamino acid metabolism_Homo sapiens_hsa004600.76166036
57Carbon metabolism_Homo sapiens_hsa012000.71747250
58Non-small cell lung cancer_Homo sapiens_hsa052230.69639664
59Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.67937175
60Prostate cancer_Homo sapiens_hsa052150.67062407
61Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.66408259
62Fatty acid biosynthesis_Homo sapiens_hsa000610.63906129
63Pancreatic cancer_Homo sapiens_hsa052120.61835838
64AMPK signaling pathway_Homo sapiens_hsa041520.60523895
65Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.59798933
66Insulin signaling pathway_Homo sapiens_hsa049100.59662367
67ErbB signaling pathway_Homo sapiens_hsa040120.57981759
68N-Glycan biosynthesis_Homo sapiens_hsa005100.57919273
69Epstein-Barr virus infection_Homo sapiens_hsa051690.56473970
70Basal transcription factors_Homo sapiens_hsa030220.55290157
71Folate biosynthesis_Homo sapiens_hsa007900.53755295
722-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.52904878
73Apoptosis_Homo sapiens_hsa042100.52552673
74FoxO signaling pathway_Homo sapiens_hsa040680.51872566
75Insulin resistance_Homo sapiens_hsa049310.51354879
76Basal cell carcinoma_Homo sapiens_hsa052170.51346491
77Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.48534948
78Proteoglycans in cancer_Homo sapiens_hsa052050.47005888
79Glucagon signaling pathway_Homo sapiens_hsa049220.45873692
80Adipocytokine signaling pathway_Homo sapiens_hsa049200.45214167
81Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.45196091
82Herpes simplex infection_Homo sapiens_hsa051680.44974594
83Inositol phosphate metabolism_Homo sapiens_hsa005620.43410758
84Pathways in cancer_Homo sapiens_hsa052000.42748703
85Hepatitis B_Homo sapiens_hsa051610.40944976
86Pyruvate metabolism_Homo sapiens_hsa006200.40810162
87Hedgehog signaling pathway_Homo sapiens_hsa043400.40529867
88Notch signaling pathway_Homo sapiens_hsa043300.37223019
89PI3K-Akt signaling pathway_Homo sapiens_hsa041510.37112366
90Wnt signaling pathway_Homo sapiens_hsa043100.36892286
91Phosphatidylinositol signaling system_Homo sapiens_hsa040700.33310205
92Oocyte meiosis_Homo sapiens_hsa041140.32776455
93ECM-receptor interaction_Homo sapiens_hsa045120.32342570
94ABC transporters_Homo sapiens_hsa020100.28019539
95Glioma_Homo sapiens_hsa052140.25469983
96Circadian rhythm_Homo sapiens_hsa047100.24299995
97Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.23217979
98Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.22380846
99Focal adhesion_Homo sapiens_hsa045100.21870091
100Aldosterone synthesis and secretion_Homo sapiens_hsa049250.21257658

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