AKR1E2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the aldo-keto reductase superfamily. Members in this family are characterized by their structure (evolutionarily highly conserved TIM barrel) and function (NAD(P)H-dependent oxido-reduction of carbonyl groups). Transcripts of this gene have been reported in specimens of human testis. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1chromosome condensation (GO:0030261)6.87960753
2DNA packaging (GO:0006323)6.61832667
3microtubule depolymerization (GO:0007019)6.42902953
4acrosome reaction (GO:0007340)6.24034471
5nuclear pore complex assembly (GO:0051292)6.22403929
6spermatid nucleus differentiation (GO:0007289)6.00597797
7fusion of sperm to egg plasma membrane (GO:0007342)5.54687240
8sperm motility (GO:0030317)5.32460663
9regulation of histone H3-K27 methylation (GO:0061085)4.95747118
10nuclear pore organization (GO:0006999)4.76523208
11regulation of centriole replication (GO:0046599)4.63009375
12binding of sperm to zona pellucida (GO:0007339)4.56167319
13pore complex assembly (GO:0046931)4.52998358
14retrograde transport, vesicle recycling within Golgi (GO:0000301)4.44175945
15microtubule polymerization or depolymerization (GO:0031109)4.42838058
16protein targeting to Golgi (GO:0000042)4.38489983
17single strand break repair (GO:0000012)4.29375044
18sperm-egg recognition (GO:0035036)4.27729776
19rRNA methylation (GO:0031167)4.26249282
20sperm capacitation (GO:0048240)4.10194990
21nucleus organization (GO:0006997)4.08033680
22plasma membrane fusion (GO:0045026)4.06242828
23establishment of protein localization to Golgi (GO:0072600)4.05323970
24histone H3-K9 demethylation (GO:0033169)4.01811619
25protein polyglutamylation (GO:0018095)3.98579927
26spermatid development (GO:0007286)3.87431987
27negative regulation of inclusion body assembly (GO:0090084)3.69441710
28resolution of meiotic recombination intermediates (GO:0000712)3.68665383
29protein depolymerization (GO:0051261)3.67167544
30nucleosome disassembly (GO:0006337)3.55590917
31protein-DNA complex disassembly (GO:0032986)3.55590917
32sexual reproduction (GO:0019953)3.51868876
33negative regulation of DNA repair (GO:0045738)3.38423112
34negative regulation of histone methylation (GO:0031061)3.38039213
35cell-cell recognition (GO:0009988)3.35986890
36spermatogenesis (GO:0007283)3.31834115
37male gamete generation (GO:0048232)3.31582690
38rRNA modification (GO:0000154)3.30070605
39regulation of histone H3-K9 methylation (GO:0051570)3.29724242
40protoporphyrinogen IX metabolic process (GO:0046501)3.29253226
41DNA conformation change (GO:0071103)3.27267945
42hepatocyte apoptotic process (GO:0097284)3.26815044
43motile cilium assembly (GO:0044458)3.24002842
44multicellular organism reproduction (GO:0032504)3.20583373
45regulation of RNA export from nucleus (GO:0046831)3.19410327
46erythrocyte maturation (GO:0043249)3.16632999
47reproduction (GO:0000003)3.13006805
48gamete generation (GO:0007276)3.08963376
49glomerular visceral epithelial cell development (GO:0072015)3.08810976
50definitive hemopoiesis (GO:0060216)3.08725266
51peptidyl-lysine dimethylation (GO:0018027)3.06400282
52face development (GO:0060324)3.01287474
53male meiosis (GO:0007140)3.00693155
54basic amino acid transport (GO:0015802)2.99392854
55microtubule severing (GO:0051013)2.98410173
56peptidyl-proline hydroxylation (GO:0019511)2.93911275
57positive regulation of receptor recycling (GO:0001921)2.91604965
58centriole replication (GO:0007099)2.90061569
59DNA methylation involved in gamete generation (GO:0043046)2.89581030
60mitotic chromosome condensation (GO:0007076)2.89114078
61peptidyl-threonine dephosphorylation (GO:0035970)2.87768283
62gas transport (GO:0015669)2.87739411
63chromatin silencing (GO:0006342)2.86089149
64histone mRNA catabolic process (GO:0071044)2.85936723
65regulation of nucleobase-containing compound transport (GO:0032239)2.78312655
66protein localization to Golgi apparatus (GO:0034067)2.75578256
67insulin-like growth factor receptor signaling pathway (GO:0048009)2.74950695
68centriole assembly (GO:0098534)2.74809299
69coronary vasculature morphogenesis (GO:0060977)2.74303100
70microtubule nucleation (GO:0007020)2.73328790
71phosphatidylethanolamine biosynthetic process (GO:0006646)2.73039035
72regulation of Rab GTPase activity (GO:0032313)2.72275598
73positive regulation of Rab GTPase activity (GO:0032851)2.72275598
74cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.71889407
75protein K48-linked deubiquitination (GO:0071108)2.70736088
76meiosis I (GO:0007127)2.70615565
77germ cell development (GO:0007281)2.68683286
78positive regulation of Cdc42 GTPase activity (GO:0043089)2.66553850
79glomerular epithelial cell development (GO:0072310)2.64915197
80glycerol ether metabolic process (GO:0006662)2.64863827
81cellular process involved in reproduction in multicellular organism (GO:0022412)2.64779187
82nuclear envelope disassembly (GO:0051081)2.61271750
83membrane disassembly (GO:0030397)2.61271750
84mitotic nuclear envelope disassembly (GO:0007077)2.60256582
85mitotic metaphase plate congression (GO:0007080)2.59029156
86extracellular fibril organization (GO:0043206)2.58920303
87multicellular organismal reproductive process (GO:0048609)2.57583854
88protein export from nucleus (GO:0006611)2.54637555
89cytoskeletal anchoring at plasma membrane (GO:0007016)2.54396062
90regulation of integrin activation (GO:0033623)2.54195279
91synaptonemal complex assembly (GO:0007130)2.53506786
92regulation of histone methylation (GO:0031060)2.51958489
93retinoic acid receptor signaling pathway (GO:0048384)2.50626195
94regulation of translational fidelity (GO:0006450)2.49530869
95negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.48499037
96negative regulation of adherens junction organization (GO:1903392)2.48119169
97negative regulation of focal adhesion assembly (GO:0051895)2.48119169
98negative regulation of cell junction assembly (GO:1901889)2.48119169
99membrane protein ectodomain proteolysis (GO:0006509)2.45842526
100calcium ion-dependent exocytosis (GO:0017156)2.43984555

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.78604664
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.62679469
3GATA1_19941826_ChIP-Seq_K562_Human3.50688332
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.13154904
5SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.77918278
6GATA2_19941826_ChIP-Seq_K562_Human2.59511229
7GATA1_22025678_ChIP-Seq_K562_Human2.54387989
8SCL_19346495_ChIP-Seq_HPC-7_Human2.49306553
9EGR1_19374776_ChIP-ChIP_THP-1_Human2.46582680
10NCOR1_26117541_ChIP-Seq_K562_Human2.41101846
11NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.30354281
12FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.27563075
13PRDM5_23873026_ChIP-Seq_MEFs_Mouse2.27252585
14DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.21534237
15STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.18508691
16ZNF217_24962896_ChIP-Seq_MCF-7_Human2.08405255
17SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human2.06851311
18CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.99632471
19ESR1_20079471_ChIP-ChIP_T-47D_Human1.94462308
20MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.93475691
21TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.90985203
22HIF1A_21447827_ChIP-Seq_MCF-7_Human1.84379770
23SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.82278467
24SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.82278467
25SALL1_21062744_ChIP-ChIP_HESCs_Human1.80872821
26SPI1_23127762_ChIP-Seq_K562_Human1.80434399
27* RUNX1_27514584_Chip-Seq_MCF-7_Human1.79365807
28* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.77156621
29PKCTHETA_26484144_Chip-Seq_BREAST_Human1.72694535
30TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.71544878
31ATF3_27146783_Chip-Seq_COLON_Human1.67147766
32PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.64179346
33* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.64074045
34RARG_19884340_ChIP-ChIP_MEFs_Mouse1.62593250
35ARNT_22903824_ChIP-Seq_MCF-7_Human1.61099539
36POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.59463592
37STAT6_21828071_ChIP-Seq_BEAS2B_Human1.57630911
38RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.56860289
39KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.54021194
40EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.52166112
41ELK3_25401928_ChIP-Seq_HUVEC_Human1.51939744
42SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.51652348
43TDRD3_21172665_ChIP-Seq_MCF-7_Human1.51502264
44DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.50057900
45TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.48234600
46PPAR_26484153_Chip-Seq_NCI-H1993_Human1.48221099
47CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.47617279
48GATA2_21666600_ChIP-Seq_HMVEC_Human1.46154211
49KLF5_25053715_ChIP-Seq_YYC3_Human1.45051018
50TCF7_22412390_ChIP-Seq_EML_Mouse1.42883274
51SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.42358336
52CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.42306928
53KLF4_18555785_ChIP-Seq_MESCs_Mouse1.40510852
54TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.39527485
55AR_21909140_ChIP-Seq_LNCAP_Human1.38568802
56MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.37188780
57GATA1_22383799_ChIP-Seq_G1ME_Mouse1.37106930
58BRD4_25478319_ChIP-Seq_HGPS_Human1.35985800
59NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.33048825
60MYB_21317192_ChIP-Seq_ERMYB_Mouse1.32231453
61ESR2_21235772_ChIP-Seq_MCF-7_Human1.32114878
62P300_27058665_Chip-Seq_ZR-75-30cells_Human1.30718315
63AHR_22903824_ChIP-Seq_MCF-7_Human1.30578874
64E2F4_17652178_ChIP-ChIP_JURKAT_Human1.28404892
65CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.26690731
66JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.26379805
67TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.25749017
68SOX9_24532713_ChIP-Seq_HFSC_Mouse1.23605001
69* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.23256192
70CHD1_26751641_Chip-Seq_LNCaP_Human1.19983736
71CJUN_26792858_Chip-Seq_BT549_Human1.15941904
72KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.15231645
73JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.13966531
74TFEB_21752829_ChIP-Seq_HELA_Human1.13870919
75GATA1_19941827_ChIP-Seq_MEL_Mouse1.13622169
76NFIB_24661679_ChIP-Seq_LUNG_Mouse1.11109894
77TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.10753460
78GATA6_25053715_ChIP-Seq_YYC3_Human1.09578300
79PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.08893215
80RACK7_27058665_Chip-Seq_MCF-7_Human1.08229794
81UBF1/2_26484160_Chip-Seq_HMECs_Human1.06062632
82Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.04553260
83CTCF_21964334_Chip-Seq_Bcells_Human1.04205230
84KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.03852702
85ER_23166858_ChIP-Seq_MCF-7_Human1.01901430
86E2F1_21310950_ChIP-Seq_MCF-7_Human1.01100200
87PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.00126936
88MYCN_18555785_ChIP-Seq_MESCs_Mouse0.99067054
89FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.98305701
90ELF5_23300383_ChIP-Seq_T47D_Human0.98141374
91FOXM1_26456572_ChIP-Seq_MCF-7_Human0.97882486
92SALL4_22934838_ChIP-ChIP_CD34+_Human0.95637249
93ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.94761794
94ESR1_15608294_ChIP-ChIP_MCF-7_Human0.94000687
95VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.93759851
96ELF1_20517297_ChIP-Seq_JURKAT_Human0.93744442
97THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.92426266
98KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.92345705
99GATA1_19941827_ChIP-Seq_MEL86_Mouse0.91389736
100HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.88270502

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization5.46970263
2MP0003705_abnormal_hypodermis_morpholog4.48080193
3MP0003656_abnormal_erythrocyte_physiolo2.74551542
4MP0008438_abnormal_cutaneous_collagen2.54674577
5MP0005451_abnormal_body_composition2.52401250
6MP0004233_abnormal_muscle_weight2.51801080
7MP0005670_abnormal_white_adipose2.45634917
8MP0001929_abnormal_gametogenesis2.32393575
9MP0003698_abnormal_male_reproductive2.24021985
10MP0003950_abnormal_plasma_membrane2.20561209
11MP0003566_abnormal_cell_adhesion2.14240726
12MP0005083_abnormal_biliary_tract2.10592799
13MP0009780_abnormal_chondrocyte_physiolo1.98665199
14MP0004185_abnormal_adipocyte_glucose1.97612660
15MP0004957_abnormal_blastocyst_morpholog1.97438083
16MP0005666_abnormal_adipose_tissue1.95711891
17MP0010352_gastrointestinal_tract_polyps1.94648247
18MP0003077_abnormal_cell_cycle1.87681214
19MP0008260_abnormal_autophagy1.83930517
20MP0008057_abnormal_DNA_replication1.73210484
21MP0005076_abnormal_cell_differentiation1.73193278
22MP0001348_abnormal_lacrimal_gland1.70378743
23MP0005275_abnormal_skin_tensile1.61182018
24MP0005464_abnormal_platelet_physiology1.60695627
25MP0002877_abnormal_melanocyte_morpholog1.55137539
26MP0003091_abnormal_cell_migration1.51970256
27MP0003191_abnormal_cellular_cholesterol1.51544700
28MP0002210_abnormal_sex_determination1.49026148
29MP0005397_hematopoietic_system_phenotyp1.44327852
30MP0001545_abnormal_hematopoietic_system1.44327852
31MP0002161_abnormal_fertility/fecundity1.42652699
32MP0004272_abnormal_basement_membrane1.42024527
33MP0008004_abnormal_stomach_pH1.41397053
34MP0010094_abnormal_chromosome_stability1.38507329
35MP0004808_abnormal_hematopoietic_stem1.37368010
36MP0004264_abnormal_extraembryonic_tissu1.32954755
37MP0003718_maternal_effect1.31793630
38MP0001730_embryonic_growth_arrest1.28199558
39MP0001879_abnormal_lymphatic_vessel1.27594025
40MP0003111_abnormal_nucleus_morphology1.25153612
41MP0002086_abnormal_extraembryonic_tissu1.23429865
42MP0005375_adipose_tissue_phenotype1.22175716
43MP0003453_abnormal_keratinocyte_physiol1.21292157
44MP0005503_abnormal_tendon_morphology1.19946495
45MP0003878_abnormal_ear_physiology1.18777929
46MP0005377_hearing/vestibular/ear_phenot1.18777929
47MP0005023_abnormal_wound_healing1.17784438
48MP0002796_impaired_skin_barrier1.17524824
49MP0000678_abnormal_parathyroid_gland1.17010690
50MP0003693_abnormal_embryo_hatching1.15915384
51MP0009115_abnormal_fat_cell1.13741274
52MP0001697_abnormal_embryo_size1.11424978
53MP0001672_abnormal_embryogenesis/_devel1.11017044
54MP0005380_embryogenesis_phenotype1.11017044
55MP0002080_prenatal_lethality1.10729821
56MP0004084_abnormal_cardiac_muscle1.08820164
57MP0009697_abnormal_copulation1.07908003
58MP0004036_abnormal_muscle_relaxation1.07241660
59MP0003221_abnormal_cardiomyocyte_apopto1.05558791
60MP0001145_abnormal_male_reproductive1.04761378
61MP0008932_abnormal_embryonic_tissue1.03773713
62MP0003984_embryonic_growth_retardation1.01455356
63MP0008995_early_reproductive_senescence1.01139261
64MP0005621_abnormal_cell_physiology1.00568072
65MP0000653_abnormal_sex_gland1.00042658
66MP0002088_abnormal_embryonic_growth/wei0.98365668
67MP0002060_abnormal_skin_morphology0.97854500
68MP0008007_abnormal_cellular_replicative0.97784179
69MP0005501_abnormal_skin_physiology0.97580279
70MP0000350_abnormal_cell_proliferation0.94838292
71MP0005248_abnormal_Harderian_gland0.90003127
72MP0005409_darkened_coat_color0.88230800
73MP0000749_muscle_degeneration0.86640521
74MP0004147_increased_porphyrin_level0.86075160
75MP0000313_abnormal_cell_death0.84519219
76MP0005408_hypopigmentation0.84411027
77MP0002332_abnormal_exercise_endurance0.83619103
78MP0000733_abnormal_muscle_development0.82099029
79MP0010307_abnormal_tumor_latency0.81521956
80MP0000015_abnormal_ear_pigmentation0.81087092
81MP0002085_abnormal_embryonic_tissue0.78990918
82MP0002970_abnormal_white_adipose0.78038363
83MP0004510_myositis0.77281926
84MP0005384_cellular_phenotype0.76540935
85MP0001958_emphysema0.76198384
86MP0002127_abnormal_cardiovascular_syste0.75838240
87MP0006138_congestive_heart_failure0.75065181
88MP0001727_abnormal_embryo_implantation0.73993716
89MP0000358_abnormal_cell_content/0.73854174
90MP0003699_abnormal_female_reproductive0.73603420
91MP0002925_abnormal_cardiovascular_devel0.73195589
92MP0005310_abnormal_salivary_gland0.72443745
93MP0001243_abnormal_dermal_layer0.71944159
94MP0009278_abnormal_bone_marrow0.71509374
95MP0005058_abnormal_lysosome_morphology0.70806211
96MP0002084_abnormal_developmental_patter0.70507408
97MP0003828_pulmonary_edema0.70197121
98MP0010234_abnormal_vibrissa_follicle0.69607784
99MP0001849_ear_inflammation0.68724397
100MP0005164_abnormal_response_to0.68603484

Predicted human phenotypes

RankGene SetZ-score
1Distal lower limb amyotrophy (HP:0008944)3.47663035
2Abnormal gallbladder physiology (HP:0012438)3.45370162
3Cholecystitis (HP:0001082)3.45370162
4Reticulocytosis (HP:0001923)3.40081006
5Broad face (HP:0000283)3.38181755
6Poikilocytosis (HP:0004447)3.31496431
7Severe visual impairment (HP:0001141)3.28840304
8Distal upper limb amyotrophy (HP:0007149)3.27745471
9Upper limb amyotrophy (HP:0009129)3.27745471
10Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.14605310
11Tubulointerstitial nephritis (HP:0001970)3.13171654
12Upper limb muscle weakness (HP:0003484)3.05414496
13Short nail (HP:0001799)2.97626155
14Osteolytic defects of the hand bones (HP:0009699)2.91452775
15Osteolytic defects of the phalanges of the hand (HP:0009771)2.91452775
16Hand muscle atrophy (HP:0009130)2.86575141
17Resting tremor (HP:0002322)2.83724599
18Ileus (HP:0002595)2.78831065
19Termporal pattern (HP:0011008)2.78567467
20Insidious onset (HP:0003587)2.78567467
21Increased connective tissue (HP:0009025)2.73199735
22Abnormality of the fingertips (HP:0001211)2.72990885
23Increased mean platelet volume (HP:0011877)2.71223132
24Glucose intolerance (HP:0000833)2.69890210
25Sandal gap (HP:0001852)2.66067618
26Male infertility (HP:0003251)2.64058338
27Menstrual irregularities (HP:0000858)2.57789506
28Acute myeloid leukemia (HP:0004808)2.54995519
29Abnormality of the heme biosynthetic pathway (HP:0010472)2.53893106
30Progressive sensorineural hearing impairment (HP:0000408)2.49223003
31Nasal polyposis (HP:0100582)2.43752040
32Lower limb amyotrophy (HP:0007210)2.38058880
33Heterotopia (HP:0002282)2.35176568
34Subcapsular cataract (HP:0000523)2.34865079
35Premature rupture of membranes (HP:0001788)2.32862187
36Aplasia/Hypoplasia of the earlobes (HP:0009906)2.30521615
37Polycythemia (HP:0001901)2.28243314
38Bell-shaped thorax (HP:0001591)2.27814308
39Abnormal platelet volume (HP:0011876)2.27279380
40Cholelithiasis (HP:0001081)2.25646069
41Spinal rigidity (HP:0003306)2.24750772
42Esophageal varix (HP:0002040)2.21530052
43Aortic aneurysm (HP:0004942)2.21406099
44Abnormality of the nasal mucosa (HP:0000433)2.19264022
45Asymmetric septal hypertrophy (HP:0001670)2.17554646
46Menorrhagia (HP:0000132)2.15103705
47Abnormal large intestine physiology (HP:0012700)2.14366567
48Progressive hearing impairment (HP:0001730)2.14036480
49Bowel incontinence (HP:0002607)2.13939846
50Abnormality of the tricuspid valve (HP:0001702)2.12416943
51Atrophic scars (HP:0001075)2.10325572
52Abnormal spermatogenesis (HP:0008669)2.10286692
53Biliary tract neoplasm (HP:0100574)2.07419689
54Prolonged bleeding time (HP:0003010)2.06822814
55Cervical subluxation (HP:0003308)2.06693734
56Chromosomal breakage induced by crosslinking agents (HP:0003221)2.02876551
57Papillary thyroid carcinoma (HP:0002895)1.95312702
58Chromsome breakage (HP:0040012)1.93559462
59Abnormality of oral frenula (HP:0000190)1.92738874
60Cone-rod dystrophy (HP:0000548)1.91452815
61Acanthocytosis (HP:0001927)1.90985496
62Distal lower limb muscle weakness (HP:0009053)1.89822540
63Thin bony cortex (HP:0002753)1.88320573
64Breech presentation (HP:0001623)1.88031019
65Ankyloglossia (HP:0010296)1.87883108
66Spondylolisthesis (HP:0003302)1.87714572
67Uterine leiomyosarcoma (HP:0002891)1.87659416
68Leiomyosarcoma (HP:0100243)1.87659416
69Microglossia (HP:0000171)1.86034297
70Hyperkalemia (HP:0002153)1.85870900
71Patellar dislocation (HP:0002999)1.85818862
72Sparse lateral eyebrow (HP:0005338)1.85014091
73Deep philtrum (HP:0002002)1.84681314
74Truncal obesity (HP:0001956)1.84118284
75Decreased motor nerve conduction velocity (HP:0003431)1.83598835
76Infertility (HP:0000789)1.83182027
77Conjunctival telangiectasia (HP:0000524)1.83072221
78Joint laxity (HP:0001388)1.82645376
79Impaired platelet aggregation (HP:0003540)1.79851293
80Abnormal platelet function (HP:0011869)1.79851293
81Hypoparathyroidism (HP:0000829)1.79415592
82Abnormal gallbladder morphology (HP:0012437)1.79264946
83Abnormal glucose tolerance (HP:0001952)1.78323218
84Overgrowth (HP:0001548)1.77707768
85Convex nasal ridge (HP:0000444)1.76430645
86Abnormality of reticulocytes (HP:0004312)1.75473035
87Intellectual disability, moderate (HP:0002342)1.74570345
88Abnormality of lateral ventricle (HP:0030047)1.74554999
89Dynein arm defect of respiratory motile cilia (HP:0012255)1.73910253
90Absent/shortened dynein arms (HP:0200106)1.73910253
91Slow saccadic eye movements (HP:0000514)1.72191919
92Hyperthyroidism (HP:0000836)1.67498497
93Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.67453329
94Hypertriglyceridemia (HP:0002155)1.67332197
95Hyperacusis (HP:0010780)1.66739490
96Duodenal stenosis (HP:0100867)1.66314617
97Small intestinal stenosis (HP:0012848)1.66314617
98Flattened epiphyses (HP:0003071)1.65290721
99Ridged nail (HP:0001807)1.62998115
100Abnormality of the preputium (HP:0100587)1.62922731

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K126.83447221
2MST1R3.69848938
3PLK43.34165456
4EIF2AK12.88307497
5MAP3K112.77668945
6TRIB32.73617728
7MET2.64159485
8TESK12.57304569
9MAP2K42.14862616
10CDK121.95545599
11BMX1.91371524
12RIPK41.91209627
13STK381.86189898
14CAMK1G1.76976166
15SCYL21.66295893
16DDR21.65671288
17KSR11.63461066
18TRPM71.61243718
19PNCK1.58014138
20PBK1.48707677
21MAP3K61.48027825
22PLK21.47287937
23PTK2B1.43156547
24EEF2K1.42376871
25EPHA21.41572641
26MAP3K21.40900680
27TTN1.40656893
28MAP3K11.38728307
29WNK11.38310627
30IRAK31.28293246
31BRSK21.25371391
32KSR21.23082445
33PIK3CG1.21496568
34LATS21.19730002
35PKN21.17548927
36MYLK1.16210659
37MTOR1.15366885
38NEK61.14657305
39MARK31.13191111
40RET1.09382129
41CLK11.08066087
42MAP3K51.05411994
43ILK0.97950812
44RPS6KB20.97539610
45CDK80.95090134
46NEK10.93929667
47PDGFRA0.91746943
48CDK70.91024998
49BRD40.89109394
50MAP2K30.88586103
51CAMK1D0.83525173
52PRPF4B0.76656924
53SIK10.76438033
54PDPK10.76076480
55PAK10.73275151
56PTK20.73099396
57NME20.71414880
58STK40.71006799
59TTK0.70658703
60PDGFRB0.68519837
61MAP3K80.66792795
62PDK10.63009168
63GRK70.61985088
64MST40.58625709
65MAP2K10.57723364
66YES10.57344580
67ICK0.55160091
68BRSK10.55149304
69TGFBR20.54962489
70BRAF0.54598627
71MOS0.53309914
72MAPKAPK30.52336887
73LATS10.52187220
74PAK20.49082057
75PRKCI0.47031357
76DMPK0.46475939
77PAK40.45528395
78IRAK20.43124676
79SMG10.42924255
80CHEK10.42820641
81MAP3K100.41830487
82CDK90.40262597
83BMPR20.40054322
84CDK10.34329307
85MAPK110.32622827
86GRK60.32351459
87NEK20.30819875
88MAPKAPK20.30739490
89AURKB0.29263166
90AKT30.24947542
91MAP2K20.24325865
92TAOK20.24324303
93RAF10.24267837
94RIPK10.23962277
95ROCK10.21931479
96MELK0.20985871
97FER0.19684701
98CDK20.19603045
99LMTK20.18916026
100SGK10.18354390

Predicted pathways (KEGG)

RankGene SetZ-score
1Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.37383514
2Acute myeloid leukemia_Homo sapiens_hsa052212.22166164
3Chronic myeloid leukemia_Homo sapiens_hsa052202.05423816
4Fatty acid biosynthesis_Homo sapiens_hsa000611.96066996
5Non-small cell lung cancer_Homo sapiens_hsa052231.92364384
6ErbB signaling pathway_Homo sapiens_hsa040121.82552355
7Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.79754705
8Pancreatic cancer_Homo sapiens_hsa052121.67552349
9Thyroid cancer_Homo sapiens_hsa052161.67523136
10Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.67040530
11Mismatch repair_Homo sapiens_hsa034301.66709202
12mTOR signaling pathway_Homo sapiens_hsa041501.65241452
13Renal cell carcinoma_Homo sapiens_hsa052111.64281392
14Cell cycle_Homo sapiens_hsa041101.62207267
15RNA transport_Homo sapiens_hsa030131.61544693
16Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.59513799
17Adherens junction_Homo sapiens_hsa045201.57325358
18Endometrial cancer_Homo sapiens_hsa052131.54345900
19AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.53394037
20Focal adhesion_Homo sapiens_hsa045101.50667434
21VEGF signaling pathway_Homo sapiens_hsa043701.48861772
22Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.43801789
23Viral carcinogenesis_Homo sapiens_hsa052031.39689289
24ECM-receptor interaction_Homo sapiens_hsa045121.36680960
25Inositol phosphate metabolism_Homo sapiens_hsa005621.36314624
26Central carbon metabolism in cancer_Homo sapiens_hsa052301.35691933
27Thyroid hormone signaling pathway_Homo sapiens_hsa049191.35137507
28Platelet activation_Homo sapiens_hsa046111.32369736
29Glioma_Homo sapiens_hsa052141.31098662
30Prostate cancer_Homo sapiens_hsa052151.30112950
31Prolactin signaling pathway_Homo sapiens_hsa049171.25524843
32Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.22571044
33MicroRNAs in cancer_Homo sapiens_hsa052061.22547809
34Small cell lung cancer_Homo sapiens_hsa052221.21819460
35Phosphatidylinositol signaling system_Homo sapiens_hsa040701.19942151
36Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.18839501
37Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.16419481
38Proteoglycans in cancer_Homo sapiens_hsa052051.15660874
39Oocyte meiosis_Homo sapiens_hsa041141.13985490
40Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.12418174
41Shigellosis_Homo sapiens_hsa051311.11859907
42Hepatitis B_Homo sapiens_hsa051611.11705360
43Choline metabolism in cancer_Homo sapiens_hsa052311.08090332
44Olfactory transduction_Homo sapiens_hsa047401.03605018
45Melanoma_Homo sapiens_hsa052181.03005122
46Longevity regulating pathway - mammal_Homo sapiens_hsa042111.02609130
47Type II diabetes mellitus_Homo sapiens_hsa049300.99625407
48mRNA surveillance pathway_Homo sapiens_hsa030150.98951899
49Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.98328549
50Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.98166961
51Fanconi anemia pathway_Homo sapiens_hsa034600.97782136
52Nucleotide excision repair_Homo sapiens_hsa034200.97587387
53Endocytosis_Homo sapiens_hsa041440.97298641
54HIF-1 signaling pathway_Homo sapiens_hsa040660.97199872
55Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.96292320
56Gap junction_Homo sapiens_hsa045400.93933468
57Regulation of actin cytoskeleton_Homo sapiens_hsa048100.92104172
58Influenza A_Homo sapiens_hsa051640.90938849
59Tight junction_Homo sapiens_hsa045300.90559406
60Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.89651284
61Apoptosis_Homo sapiens_hsa042100.89061592
62Insulin signaling pathway_Homo sapiens_hsa049100.87987046
63Bladder cancer_Homo sapiens_hsa052190.85744882
64Alcoholism_Homo sapiens_hsa050340.84244629
65Dorso-ventral axis formation_Homo sapiens_hsa043200.83995038
66AMPK signaling pathway_Homo sapiens_hsa041520.83424696
67Colorectal cancer_Homo sapiens_hsa052100.83135381
68DNA replication_Homo sapiens_hsa030300.83007551
69Sphingolipid signaling pathway_Homo sapiens_hsa040710.82384942
70Adipocytokine signaling pathway_Homo sapiens_hsa049200.82146335
71Neurotrophin signaling pathway_Homo sapiens_hsa047220.81560335
72Estrogen signaling pathway_Homo sapiens_hsa049150.80211713
73Basal transcription factors_Homo sapiens_hsa030220.79005052
74Steroid biosynthesis_Homo sapiens_hsa001000.78527151
75Notch signaling pathway_Homo sapiens_hsa043300.78219799
76Pentose phosphate pathway_Homo sapiens_hsa000300.77492363
77TNF signaling pathway_Homo sapiens_hsa046680.75933911
78B cell receptor signaling pathway_Homo sapiens_hsa046620.73811129
79Phospholipase D signaling pathway_Homo sapiens_hsa040720.72620635
80Leukocyte transendothelial migration_Homo sapiens_hsa046700.72034119
81FoxO signaling pathway_Homo sapiens_hsa040680.70814953
82Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.70098992
83Toll-like receptor signaling pathway_Homo sapiens_hsa046200.68133896
84Hepatitis C_Homo sapiens_hsa051600.67634599
85Transcriptional misregulation in cancer_Homo sapiens_hsa052020.65007158
86Epstein-Barr virus infection_Homo sapiens_hsa051690.63842340
87HTLV-I infection_Homo sapiens_hsa051660.62387248
88p53 signaling pathway_Homo sapiens_hsa041150.59671452
89Insulin resistance_Homo sapiens_hsa049310.58215149
90Lysine degradation_Homo sapiens_hsa003100.56888284
91PI3K-Akt signaling pathway_Homo sapiens_hsa041510.55362848
92Amoebiasis_Homo sapiens_hsa051460.52686700
93Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.52033118
94TGF-beta signaling pathway_Homo sapiens_hsa043500.51749474
95Glycerophospholipid metabolism_Homo sapiens_hsa005640.51334503
96N-Glycan biosynthesis_Homo sapiens_hsa005100.51082598
97Jak-STAT signaling pathway_Homo sapiens_hsa046300.50297372
98Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.50222313
99MAPK signaling pathway_Homo sapiens_hsa040100.49189276
100Systemic lupus erythematosus_Homo sapiens_hsa053220.47273714

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