AKR1D1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The enzyme encoded by this gene is responsible for the catalysis of the 5-beta-reduction of bile acid intermediates and steroid hormones carrying a delta(4)-3-one structure. Deficiency of this enzyme may contribute to hepatic dysfunction. Three transcript variants encoding different isoforms have been found for this gene. Other variants may be present, but their full-length natures have not been determined yet. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.62827705
2L-phenylalanine catabolic process (GO:0006559)7.62827705
3positive regulation of heterotypic cell-cell adhesion (GO:0034116)7.38967882
4L-phenylalanine metabolic process (GO:0006558)7.27635943
5erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.27635943
6aromatic amino acid family catabolic process (GO:0009074)6.95919432
7epoxygenase P450 pathway (GO:0019373)6.73709269
8omega-hydroxylase P450 pathway (GO:0097267)6.44698428
9indole-containing compound catabolic process (GO:0042436)6.34479627
10indolalkylamine catabolic process (GO:0046218)6.34479627
11tryptophan catabolic process (GO:0006569)6.34479627
12triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.27990664
13kynurenine metabolic process (GO:0070189)6.13482853
14tryptophan metabolic process (GO:0006568)5.97642179
15glyoxylate metabolic process (GO:0046487)5.76497192
16* bile acid biosynthetic process (GO:0006699)5.74055620
17urea cycle (GO:0000050)5.72039367
18urea metabolic process (GO:0019627)5.72039367
19high-density lipoprotein particle remodeling (GO:0034375)5.58308646
20negative regulation of fibrinolysis (GO:0051918)5.56298074
21alpha-linolenic acid metabolic process (GO:0036109)5.50474418
22cysteine metabolic process (GO:0006534)5.41837407
23regulation of fibrinolysis (GO:0051917)5.35837212
24sulfur amino acid catabolic process (GO:0000098)5.35084907
25peptidyl-glutamic acid carboxylation (GO:0017187)5.34075825
26protein carboxylation (GO:0018214)5.34075825
27nitrogen cycle metabolic process (GO:0071941)5.26799160
28serine family amino acid catabolic process (GO:0009071)5.21689541
29complement activation, alternative pathway (GO:0006957)5.19904207
30regulation of protein activation cascade (GO:2000257)5.16242611
31aromatic amino acid family metabolic process (GO:0009072)5.06163748
32drug metabolic process (GO:0017144)5.04288842
33* bile acid metabolic process (GO:0008206)4.97771029
34homocysteine metabolic process (GO:0050667)4.92332719
35regulation of cholesterol esterification (GO:0010872)4.92157019
36fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.87345073
37tyrosine metabolic process (GO:0006570)4.86735606
38reverse cholesterol transport (GO:0043691)4.82357614
39oxidative demethylation (GO:0070989)4.80935592
40regulation of heterotypic cell-cell adhesion (GO:0034114)4.80688653
41regulation of complement activation (GO:0030449)4.80170744
42protein-lipid complex remodeling (GO:0034368)4.77775394
43macromolecular complex remodeling (GO:0034367)4.77775394
44plasma lipoprotein particle remodeling (GO:0034369)4.77775394
45amino-acid betaine metabolic process (GO:0006577)4.74836050
46alpha-amino acid catabolic process (GO:1901606)4.72815395
47regulation of triglyceride catabolic process (GO:0010896)4.72516582
48lysine metabolic process (GO:0006553)4.67405409
49lysine catabolic process (GO:0006554)4.67405409
50protein-lipid complex assembly (GO:0065005)4.61150270
51negative regulation of cholesterol transport (GO:0032375)4.57480786
52negative regulation of sterol transport (GO:0032372)4.57480786
53phospholipid efflux (GO:0033700)4.57227882
54acylglycerol homeostasis (GO:0055090)4.56870569
55triglyceride homeostasis (GO:0070328)4.56870569
56indolalkylamine metabolic process (GO:0006586)4.50571610
57cellular ketone body metabolic process (GO:0046950)4.49092149
58intestinal cholesterol absorption (GO:0030299)4.48608266
59bile acid and bile salt transport (GO:0015721)4.47246884
60glycine metabolic process (GO:0006544)4.45905604
61amine catabolic process (GO:0009310)4.45495427
62cellular biogenic amine catabolic process (GO:0042402)4.45495427
63S-adenosylmethionine metabolic process (GO:0046500)4.43363725
64cellular glucuronidation (GO:0052695)4.41761558
65imidazole-containing compound metabolic process (GO:0052803)4.40980379
66phenylpropanoid metabolic process (GO:0009698)4.34626404
67cellular amino acid catabolic process (GO:0009063)4.34443273
68plasma lipoprotein particle clearance (GO:0034381)4.34411701
69benzene-containing compound metabolic process (GO:0042537)4.33753481
70ethanol metabolic process (GO:0006067)4.32562699
71coenzyme catabolic process (GO:0009109)4.26398886
72serine family amino acid metabolic process (GO:0009069)4.25502450
73glutamate metabolic process (GO:0006536)4.23222940
74cholesterol efflux (GO:0033344)4.21535964
75drug catabolic process (GO:0042737)4.20044862
76low-density lipoprotein particle remodeling (GO:0034374)4.11979707
77serine family amino acid biosynthetic process (GO:0009070)4.09464091
78aldehyde catabolic process (GO:0046185)4.09345456
79ethanol oxidation (GO:0006069)4.07872299
80cellular modified amino acid catabolic process (GO:0042219)4.05640264
81arginine metabolic process (GO:0006525)4.02737840
82protein-lipid complex subunit organization (GO:0071825)4.02294901
83negative regulation of protein activation cascade (GO:2000258)4.00765958
84dicarboxylic acid biosynthetic process (GO:0043650)4.00248725
85regulation of cytokine secretion involved in immune response (GO:0002739)3.98753964
86plasma lipoprotein particle assembly (GO:0034377)3.98236780
87fibrinolysis (GO:0042730)3.96850533
88glucuronate metabolic process (GO:0019585)3.93948035
89uronic acid metabolic process (GO:0006063)3.93948035
90ketone body metabolic process (GO:1902224)3.88384486
91blood coagulation, intrinsic pathway (GO:0007597)3.85488176
92very-low-density lipoprotein particle assembly (GO:0034379)3.81198538
93heme transport (GO:0015886)3.78234950
94short-chain fatty acid metabolic process (GO:0046459)3.77681695
95* organic acid catabolic process (GO:0016054)3.77040973
96* carboxylic acid catabolic process (GO:0046395)3.77040973
97regulation of bile acid biosynthetic process (GO:0070857)3.76433523
98negative regulation of lipase activity (GO:0060192)3.76133575
99cofactor catabolic process (GO:0051187)3.75880031
100phospholipid homeostasis (GO:0055091)3.74431202
101regulation of plasminogen activation (GO:0010755)3.72954686
102cholesterol homeostasis (GO:0042632)3.71927571
103positive regulation of lipid catabolic process (GO:0050996)3.71686488
104positive regulation of triglyceride lipase activity (GO:0061365)3.71361273
105positive regulation of lipoprotein lipase activity (GO:0051006)3.71361273
106NAD biosynthetic process (GO:0009435)3.68966317
107flavonoid metabolic process (GO:0009812)3.66776015
108protein activation cascade (GO:0072376)3.66642205
109response to nitrosative stress (GO:0051409)3.66116267
110sterol homeostasis (GO:0055092)3.65846626
111complement activation (GO:0006956)3.64764189
112complement activation, classical pathway (GO:0006958)3.63857660
113nicotinamide nucleotide biosynthetic process (GO:0019359)3.63483298
114pyridine nucleotide biosynthetic process (GO:0019363)3.63483298
115exogenous drug catabolic process (GO:0042738)3.63037926
116plasma lipoprotein particle organization (GO:0071827)3.62158479
117cholesterol transport (GO:0030301)3.59423299
118sterol transport (GO:0015918)3.59423299
119alkaloid metabolic process (GO:0009820)3.52265584
120negative regulation of hemostasis (GO:1900047)3.51104824
121negative regulation of blood coagulation (GO:0030195)3.51104824
122lipoprotein metabolic process (GO:0042157)3.48861981
123water-soluble vitamin biosynthetic process (GO:0042364)3.46242561
124regulation of humoral immune response (GO:0002920)3.32642884
125arginine catabolic process (GO:0006527)3.25791423

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse8.42979050
2* EGR1_23403033_ChIP-Seq_LIVER_Mouse7.22288036
3PPARA_22158963_ChIP-Seq_LIVER_Mouse7.21429047
4* LXR_22158963_ChIP-Seq_LIVER_Mouse6.52245960
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.27102390
6* CEBPA_23403033_ChIP-Seq_LIVER_Mouse5.19701182
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.71922631
8* CEBPB_23403033_ChIP-Seq_LIVER_Mouse4.04197577
9* NR1I2_20693526_ChIP-Seq_LIVER_Mouse4.00190493
10ZNF274_21170338_ChIP-Seq_K562_Hela2.79419921
11TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.10324628
12VDR_22108803_ChIP-Seq_LS180_Human2.05781690
13HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.03544766
14ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.9759428
15TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.91412047
16TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.87178823
17GBX2_23144817_ChIP-Seq_PC3_Human1.83690989
18POU3F2_20337985_ChIP-ChIP_501MEL_Human1.79170868
19ER_23166858_ChIP-Seq_MCF-7_Human1.65617568
20HTT_18923047_ChIP-ChIP_STHdh_Human1.65262464
21IGF1R_20145208_ChIP-Seq_DFB_Human1.61200902
22* FOXA2_19822575_ChIP-Seq_HepG2_Human1.55352138
23* BCAT_22108803_ChIP-Seq_LS180_Human1.49001768
24ZFP57_27257070_Chip-Seq_ESCs_Mouse1.47788783
25ETV2_25802403_ChIP-Seq_MESCs_Mouse1.45725391
26CTBP1_25329375_ChIP-Seq_LNCAP_Human1.45701743
27GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.45294169
28CLOCK_20551151_ChIP-Seq_293T_Human1.43346850
29* HNF4A_19822575_ChIP-Seq_HepG2_Human1.41496490
30GATA1_22025678_ChIP-Seq_K562_Human1.38935124
31KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.38553546
32HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.36281610
33UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.32507098
34FUS_26573619_Chip-Seq_HEK293_Human1.30420085
35CBP_20019798_ChIP-Seq_JUKART_Human1.30262240
36IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.30262240
37ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.29849556
38CTBP2_25329375_ChIP-Seq_LNCAP_Human1.27945080
39STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.26559591
40* NANOG_19829295_ChIP-Seq_ESCs_Human1.26163075
41* SOX2_19829295_ChIP-Seq_ESCs_Human1.26163075
42KLF5_20875108_ChIP-Seq_MESCs_Mouse1.26029769
43RXRA_24833708_ChIP-Seq_LIVER_Mouse1.21887054
44* TCF4_22108803_ChIP-Seq_LS180_Human1.20919564
45* P300_19829295_ChIP-Seq_ESCs_Human1.20564566
46STAT3_23295773_ChIP-Seq_U87_Human1.18703980
47HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.18151204
48FOXA1_25329375_ChIP-Seq_VCAP_Human1.17569163
49FOXA1_27270436_Chip-Seq_PROSTATE_Human1.17569163
50PCGF2_27294783_Chip-Seq_NPCs_Mouse1.15742781
51EZH2_22144423_ChIP-Seq_EOC_Human1.15660328
52MYC_19829295_ChIP-Seq_ESCs_Human1.15320515
53IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.14968789
54CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.13809857
55EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.12889285
56THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.11471879
57* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.08783569
58STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.07018878
59TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.06610159
60PIAS1_25552417_ChIP-Seq_VCAP_Human1.05844703
61* TCF4_23295773_ChIP-Seq_U87_Human1.04101723
62GATA3_21878914_ChIP-Seq_MCF-7_Human1.02393654
63NFE2_27457419_Chip-Seq_LIVER_Mouse1.01375809
64IRF8_22096565_ChIP-ChIP_GC-B_Human1.01362629
65FLI1_27457419_Chip-Seq_LIVER_Mouse1.00811486
66ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.00550459
67PHF8_20622853_ChIP-Seq_HELA_Human1.00526171
68ESR1_15608294_ChIP-ChIP_MCF-7_Human1.00415287
69OCT4_20526341_ChIP-Seq_ESCs_Human0.99572540
70PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.98936432
71* ERA_21632823_ChIP-Seq_H3396_Human0.98910067
72FOXA1_21572438_ChIP-Seq_LNCaP_Human0.97874360
73SMAD4_21741376_ChIP-Seq_EPCs_Human0.97115956
74CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.96059843
75PCGF2_27294783_Chip-Seq_ESCs_Mouse0.95515774
76SUZ12_27294783_Chip-Seq_NPCs_Mouse0.93913854
77MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.93805087
78GABP_17652178_ChIP-ChIP_JURKAT_Human0.93704357
79AR_25329375_ChIP-Seq_VCAP_Human0.93269734
80SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.92400627
81PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.92271823
82SMAD4_21799915_ChIP-Seq_A2780_Human0.91588870
83NR3C1_21868756_ChIP-Seq_MCF10A_Human0.91193770
84HNFA_21074721_ChIP-Seq_CACO-2_Human0.89533801
85* KAP1_22055183_ChIP-Seq_ESCs_Mouse0.88659830
86NANOG_20526341_ChIP-Seq_ESCs_Human0.88638688
87SOX2_27498859_Chip-Seq_STOMACH_Mouse0.87892020
88RUNX2_22187159_ChIP-Seq_PCA_Human0.87003331
89SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.86832803
90AUTS2_25519132_ChIP-Seq_293T-REX_Human0.86712346
91ETV1_20927104_ChIP-Seq_GIST48_Human0.86268482
92SMAD3_21741376_ChIP-Seq_EPCs_Human0.86060742
93ERG_20517297_ChIP-Seq_VCAP_Human0.86039926
94FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.84535695
95SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.84188758
96NFYA_21822215_ChIP-Seq_K562_Human0.83197739
97RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.83044890
98GATA4_25053715_ChIP-Seq_YYC3_Human0.82371947
99Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.80236695
100BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.74648574
101RARA_24833708_ChIP-Seq_LIVER_Mouse0.74542743
102SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.74075663
103RARG_19884340_ChIP-ChIP_MEFs_Mouse0.73766840
104E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.73680393
105ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.72981069
106SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.71791833
107ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.70175423
108CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.68525700
109SALL4_18804426_ChIP-ChIP_XEN_Mouse0.67586013
110NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.66937454
111NRF2_20460467_ChIP-Seq_MEFs_Mouse0.66937454
112NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.66549320
113RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.65031049
114BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.64773234
115* AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.63232679
116RAD21_21589869_ChIP-Seq_MESCs_Mouse0.61480172
117RARB_24833708_ChIP-Seq_LIVER_Mouse0.61103364
118CEBPB_22108803_ChIP-Seq_LS180_Human0.59653283
119TAF15_26573619_Chip-Seq_HEK293_Human0.57653727
120ZNF263_19887448_ChIP-Seq_K562_Human0.57390040
121AR_20517297_ChIP-Seq_VCAP_Human0.57323686
122NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.57271931
123ESR2_21235772_ChIP-Seq_MCF-7_Human0.55358904
124NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.54640454
125* STAT1_17558387_ChIP-Seq_HELA_Human0.53890453
126EGR1_19032775_ChIP-ChIP_M12_Human0.53508594
127PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.51943787
128FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.51549989
129FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.51379306
130ESET_19884257_ChIP-Seq_ESCs_Mouse0.51306124
131* FOXA1_25552417_ChIP-Seq_VCAP_Human0.49563083
132GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.49466764
133CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.48983845
134CBP_21632823_ChIP-Seq_H3396_Human0.48792026
135* MYC_19915707_ChIP-ChIP_AK7_Human0.48754225
136* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.48204650
137P53_21459846_ChIP-Seq_SAOS-2_Human0.45638251
138SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.45203936
139IRF1_19129219_ChIP-ChIP_H3396_Human0.44755024
140STAT3_1855785_ChIP-Seq_MESCs_Mouse0.44670362
141CDX2_20551321_ChIP-Seq_CACO-2_Human0.44460453
142PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.44113909
143ESR1_21235772_ChIP-Seq_MCF-7_Human0.43311032
144FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.41507838
145TAF2_19829295_ChIP-Seq_ESCs_Human0.40640312
146CRX_20693478_ChIP-Seq_RETINA_Mouse0.38516589
147GATA1_19941827_ChIP-Seq_MEL_Mouse0.38473975
148OCT4_21477851_ChIP-Seq_ESCs_Mouse0.37477208
149PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.37389803
150FOXH1_21741376_ChIP-Seq_EPCs_Human0.37215720
151EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.36494842
152NCOR_22424771_ChIP-Seq_293T_Human0.35972123
153EZH2_27294783_Chip-Seq_NPCs_Mouse0.35891537
154GATA2_19941826_ChIP-Seq_K562_Human0.35801111
155LXR_22292898_ChIP-Seq_THP-1_Human0.35698912
156PPAR_26484153_Chip-Seq_NCI-H1993_Human0.35605726
157ESR1_20079471_ChIP-ChIP_T-47D_Human0.35388186
158* CDX2_22108803_ChIP-Seq_LS180_Human0.35319550
159GATA6_25053715_ChIP-Seq_YYC3_Human0.35291005
160SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.35290446
161GATA1_19941826_ChIP-Seq_K562_Human0.34970206
162STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.34660056
163LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.34656208
164SPI1_26923725_Chip-Seq_HPCs_Mouse0.34655783
165FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.34218237

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.35040222
2MP0005360_urolithiasis7.61842199
3MP0005085_abnormal_gallbladder_physiolo6.44142086
4MP0005365_abnormal_bile_salt6.20517838
5MP0008875_abnormal_xenobiotic_pharmacok5.33868416
6MP0003806_abnormal_nucleotide_metabolis4.24337834
7MP0003252_abnormal_bile_duct3.90901438
8MP0010329_abnormal_lipoprotein_level3.52596693
9MP0009840_abnormal_foam_cell3.13175144
10MP0005083_abnormal_biliary_tract3.02633317
11MP0003195_calcinosis2.90570782
12MP0005332_abnormal_amino_acid2.82510659
13MP0001986_abnormal_taste_sensitivity2.82115294
14MP0001666_abnormal_nutrient_absorption2.56434441
15MP0004019_abnormal_vitamin_homeostasis2.27618878
16MP0003191_abnormal_cellular_cholesterol2.18069418
17MP0000609_abnormal_liver_physiology2.12894936
18MP0002118_abnormal_lipid_homeostasis2.06315299
19MP0002138_abnormal_hepatobiliary_system2.06244434
20MP0003868_abnormal_feces_composition1.87875987
21MP0005319_abnormal_enzyme/_coenzyme1.83962633
22MP0001764_abnormal_homeostasis1.75545980
23MP0009697_abnormal_copulation1.71115851
24MP0005584_abnormal_enzyme/coenzyme_acti1.57043601
25MP0005451_abnormal_body_composition1.49429555
26MP0003186_abnormal_redox_activity1.38341391
27MP0002102_abnormal_ear_morphology1.34637234
28MP0005551_abnormal_eye_electrophysiolog1.32030173
29MP0003011_delayed_dark_adaptation1.31979944
30MP0003122_maternal_imprinting1.30420054
31MP0009643_abnormal_urine_homeostasis1.29687001
32MP0004133_heterotaxia1.22097108
33MP0003646_muscle_fatigue1.19991238
34MP0003656_abnormal_erythrocyte_physiolo1.19713665
35MP0000598_abnormal_liver_morphology1.16587741
36MP0005647_abnormal_sex_gland1.14360985
37MP0009764_decreased_sensitivity_to1.12458333
38MP0009763_increased_sensitivity_to1.03323752
39MP0003283_abnormal_digestive_organ1.02837988
40MP0005379_endocrine/exocrine_gland_phen1.01225447
41MP0000604_amyloidosis0.99017694
42MP0005636_abnormal_mineral_homeostasis0.98034787
43MP0002254_reproductive_system_inflammat0.95850047
44MP0004043_abnormal_pH_regulation0.93612925
45MP0008877_abnormal_DNA_methylation0.92470469
46MP0008469_abnormal_protein_level0.92009458
47MP0003705_abnormal_hypodermis_morpholog0.91588816
48MP0005408_hypopigmentation0.91114449
49MP0004142_abnormal_muscle_tone0.90633762
50MP0002876_abnormal_thyroid_physiology0.88488237
51MP0005084_abnormal_gallbladder_morpholo0.88015671
52MP0009642_abnormal_blood_homeostasis0.87917507
53MP0010368_abnormal_lymphatic_system0.87251739
54MP0002736_abnormal_nociception_after0.84882013
55MP0006036_abnormal_mitochondrial_physio0.84018654
56MP0005646_abnormal_pituitary_gland0.83526834
57MP0009765_abnormal_xenobiotic_induced0.81849480
58MP0002938_white_spotting0.81297210
59MP0005670_abnormal_white_adipose0.81178723
60MP0005410_abnormal_fertilization0.80532315
61MP0005376_homeostasis/metabolism_phenot0.79529536
62MP0008995_early_reproductive_senescence0.79392309
63MP0002638_abnormal_pupillary_reflex0.78829658
64MP0005187_abnormal_penis_morphology0.76577289
65MP0002078_abnormal_glucose_homeostasis0.76176688
66MP0005377_hearing/vestibular/ear_phenot0.75624885
67MP0003878_abnormal_ear_physiology0.75624885
68MP0003879_abnormal_hair_cell0.74024515
69MP0005220_abnormal_exocrine_pancreas0.70792658
70MP0001661_extended_life_span0.70746431
71MP0001968_abnormal_touch/_nociception0.68488070
72MP0006276_abnormal_autonomic_nervous0.67519315
73MP0005334_abnormal_fat_pad0.67466646
74MP0005535_abnormal_body_temperature0.66533272
75MP0004147_increased_porphyrin_level0.66032015
76MP0002971_abnormal_brown_adipose0.65852897
77MP0009053_abnormal_anal_canal0.65627218
78MP0002282_abnormal_trachea_morphology0.64827216
79MP0003690_abnormal_glial_cell0.63892518
80MP0006292_abnormal_olfactory_placode0.63471143
81MP0001756_abnormal_urination0.63429606
82MP0005266_abnormal_metabolism0.62481073
83MP0000639_abnormal_adrenal_gland0.60933231
84MP0004130_abnormal_muscle_cell0.59017397
85MP0006035_abnormal_mitochondrial_morpho0.58527080
86MP0000566_synostosis0.58119964
87MP0003136_yellow_coat_color0.57848154
88MP0000647_abnormal_sebaceous_gland0.57584949
89MP0005464_abnormal_platelet_physiology0.55300294
90MP0001324_abnormal_eye_pigmentation0.54863612
91MP0000372_irregular_coat_pigmentation0.54440553
92MP0004782_abnormal_surfactant_physiolog0.54414305
93MP0003315_abnormal_perineum_morphology0.53629459
94MP0005448_abnormal_energy_balance0.53423236
95MP0003718_maternal_effect0.53260081
96MP0005645_abnormal_hypothalamus_physiol0.52344115
97MP0003329_amyloid_beta_deposits0.52271901
98MP0009745_abnormal_behavioral_response0.50969737
99MP0005395_other_phenotype0.50781004
100MP0002136_abnormal_kidney_physiology0.50599085
101MP0002928_abnormal_bile_duct0.50166639
102MP0003121_genomic_imprinting0.49959082
103MP0000467_abnormal_esophagus_morphology0.49424753
104MP0003724_increased_susceptibility_to0.49167607
105MP0001119_abnormal_female_reproductive0.48776987
106MP0002557_abnormal_social/conspecific_i0.48070580
107MP0002822_catalepsy0.47822858
108MP0003638_abnormal_response/metabolism_0.47551740
109MP0001984_abnormal_olfaction0.46880129
110MP0008873_increased_physiological_sensi0.45408338
111MP0008874_decreased_physiological_sensi0.45018472
112MP0003436_decreased_susceptibility_to0.44663937
113MP0001944_abnormal_pancreas_morphology0.44558369
114MP0001485_abnormal_pinna_reflex0.44055011
115MP0002234_abnormal_pharynx_morphology0.43986389
116MP0002909_abnormal_adrenal_gland0.43225046
117MP0008872_abnormal_physiological_respon0.42959655
118MP0005253_abnormal_eye_physiology0.42448417
119MP0005248_abnormal_Harderian_gland0.41709076
120MP0003953_abnormal_hormone_level0.41444323
121MP0009672_abnormal_birth_weight0.36798349
122MP0003075_altered_response_to0.36155265
123MP0001853_heart_inflammation0.35777791
124MP0004381_abnormal_hair_follicle0.35344660
125MP0006082_CNS_inflammation0.35003388
126MP0005166_decreased_susceptibility_to0.34080662
127MP0000230_abnormal_systemic_arterial0.32727294
128MP0002132_abnormal_respiratory_system0.31285373
129MP0009115_abnormal_fat_cell0.31187740
130MP0002168_other_aberrant_phenotype0.31061013
131MP0002837_dystrophic_cardiac_calcinosis0.31014836
132MP0001845_abnormal_inflammatory_respons0.30610436
133MP0000249_abnormal_blood_vessel0.30552513
134MP0001243_abnormal_dermal_layer0.30354436
135MP0004883_abnormal_blood_vessel0.29961850
136MP0005666_abnormal_adipose_tissue0.28854142
137MP0000579_abnormal_nail_morphology0.28702529
138MP0001881_abnormal_mammary_gland0.28163987
139MP0002970_abnormal_white_adipose0.26038258
140MP0002796_impaired_skin_barrier0.25682551
141MP0005164_abnormal_response_to0.22994965
142MP0002060_abnormal_skin_morphology0.22899097
143MP0002135_abnormal_kidney_morphology0.22891944
144MP0002090_abnormal_vision0.22730576

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)7.49191919
2Deep venous thrombosis (HP:0002625)7.42246419
3* Intrahepatic cholestasis (HP:0001406)6.79647789
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.79530021
5Prolonged partial thromboplastin time (HP:0003645)6.68258464
6Hypobetalipoproteinemia (HP:0003563)6.53296247
7Xanthomatosis (HP:0000991)6.24409547
8Hyperlipoproteinemia (HP:0010980)5.57935082
9Complement deficiency (HP:0004431)5.11369687
10Joint hemorrhage (HP:0005261)4.95688284
11Hypolipoproteinemia (HP:0010981)4.81430148
12Hyperammonemia (HP:0001987)4.68024261
13Epidermoid cyst (HP:0200040)4.53807121
14Hyperglycinemia (HP:0002154)4.52521240
15Abnormality of the common coagulation pathway (HP:0010990)4.44758151
16Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.43333524
17Abnormality of methionine metabolism (HP:0010901)4.42085859
18Abnormality of sulfur amino acid metabolism (HP:0004339)4.34916185
19Abnormality of glutamine family amino acid metabolism (HP:0010902)4.32526395
20Ketosis (HP:0001946)4.29853927
21Abnormality of aspartate family amino acid metabolism (HP:0010899)4.28962081
22Hyperglycinuria (HP:0003108)4.12269027
23Hypoalphalipoproteinemia (HP:0003233)4.11808403
24Abnormality of pyrimidine metabolism (HP:0004353)4.06953848
25Abnormality of glycine metabolism (HP:0010895)4.04462446
26Abnormality of serine family amino acid metabolism (HP:0010894)4.04462446
27Hypoglycemic coma (HP:0001325)3.92782712
28Conjugated hyperbilirubinemia (HP:0002908)3.90570139
29* Fat malabsorption (HP:0002630)3.79574480
30Abnormality of the intrinsic pathway (HP:0010989)3.76647630
31Abnormality of complement system (HP:0005339)3.72412248
32Hypercholesterolemia (HP:0003124)3.68251643
33Abnormality of fatty-acid metabolism (HP:0004359)3.43706806
34Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.37521601
35Delayed CNS myelination (HP:0002188)3.25038996
36Abnormality of nucleobase metabolism (HP:0010932)3.21825463
37Abnormality of serum amino acid levels (HP:0003112)3.18666720
38* Hyperbilirubinemia (HP:0002904)3.17285850
39Ketoacidosis (HP:0001993)3.09785164
40Hepatocellular carcinoma (HP:0001402)2.99818186
41Hypochromic microcytic anemia (HP:0004840)2.95450914
42Spontaneous abortion (HP:0005268)2.93363950
43Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.90727558
44Abnormality of alanine metabolism (HP:0010916)2.90727558
45Hyperalaninemia (HP:0003348)2.90727558
46Myocardial infarction (HP:0001658)2.87540425
47Metabolic acidosis (HP:0001942)2.84824912
48Abnormality of purine metabolism (HP:0004352)2.79261271
49Vascular calcification (HP:0004934)2.73177629
50Skin nodule (HP:0200036)2.73161182
51Lethargy (HP:0001254)2.72118198
52Retinal atrophy (HP:0001105)2.68190376
53Abnormality of dicarboxylic acid metabolism (HP:0010995)2.66641736
54Dicarboxylic aciduria (HP:0003215)2.66641736
55Systemic lupus erythematosus (HP:0002725)2.64079370
56Acanthocytosis (HP:0001927)2.57875500
57* Steatorrhea (HP:0002570)2.57460746
58Hypoglycemic seizures (HP:0002173)2.56490783
59Cerebral edema (HP:0002181)2.53747436
60Glomerulonephritis (HP:0000099)2.53720020
61Bile duct proliferation (HP:0001408)2.52563815
62Abnormal biliary tract physiology (HP:0012439)2.52563815
63Joint swelling (HP:0001386)2.50968389
64Gout (HP:0001997)2.50088924
65Spastic diplegia (HP:0001264)2.43474080
66Cardiovascular calcification (HP:0011915)2.40964464
67Abnormal gallbladder morphology (HP:0012437)2.40657470
68Mitral stenosis (HP:0001718)2.39781613
69Irritability (HP:0000737)2.39466803
70Fair hair (HP:0002286)2.33068536
71Cholelithiasis (HP:0001081)2.32035231
72Methylmalonic acidemia (HP:0002912)2.30524613
73Acute encephalopathy (HP:0006846)2.27489458
74Malnutrition (HP:0004395)2.25536153
75Recurrent gram-negative bacterial infections (HP:0005420)2.25215974
76Concave nail (HP:0001598)2.24417335
77Osteomalacia (HP:0002749)2.24339255
78Hypothermia (HP:0002045)2.23655070
79Gingival bleeding (HP:0000225)2.22308334
80Generalized aminoaciduria (HP:0002909)2.22067413
81Menorrhagia (HP:0000132)2.20693861
82Cholecystitis (HP:0001082)2.20613349
83Abnormal gallbladder physiology (HP:0012438)2.20613349
84Esophageal varix (HP:0002040)2.19764732
85Enlarged kidneys (HP:0000105)2.18865264
86Increased serum pyruvate (HP:0003542)2.18742814
87Pancreatitis (HP:0001733)2.18493306
88Amyloidosis (HP:0011034)2.17827039
89Abnormality of vitamin B metabolism (HP:0004340)2.15012696
90Vomiting (HP:0002013)2.13080068
91Brushfield spots (HP:0001088)2.12656518
92Opisthotonus (HP:0002179)2.12223782
93Late onset (HP:0003584)2.09401236
94Sensorimotor neuropathy (HP:0007141)2.09394758
95Thrombophlebitis (HP:0004418)2.07785664
96Hyperphosphaturia (HP:0003109)2.07665011
97Renal cortical cysts (HP:0000803)2.07253726
98Poikilocytosis (HP:0004447)2.04936201
99Alkalosis (HP:0001948)2.04896016
100Hyperinsulinemic hypoglycemia (HP:0000825)2.03431662
101Abnormal delivery (HP:0001787)2.02511646
102Abnormality of the renal cortex (HP:0011035)2.00815925
103Abnormality of the vitamin B12 metabolism (HP:0004341)2.00342056
104Methylmalonic aciduria (HP:0012120)2.00267232
105Rickets (HP:0002748)2.00003402
106Abnormality of the gallbladder (HP:0005264)1.94983728
107Hydroxyprolinuria (HP:0003080)1.93013270
108Abnormality of proline metabolism (HP:0010907)1.93013270
109Hemorrhage of the eye (HP:0011885)1.90768205
110Hypophosphatemic rickets (HP:0004912)1.90628962
111* Neonatal onset (HP:0003623)1.90419127
112Abnormality of iron homeostasis (HP:0011031)1.89964994
113Proximal tubulopathy (HP:0000114)1.89080916
114Abnormality of transition element cation homeostasis (HP:0011030)1.88262166
115Abnormal cartilage morphology (HP:0002763)1.82919812
116Arthropathy (HP:0003040)1.81971460
117Hepatic necrosis (HP:0002605)1.81218002
118Abnormality of vitamin metabolism (HP:0100508)1.80354990
119Glycosuria (HP:0003076)1.79858147
120Abnormality of urine glucose concentration (HP:0011016)1.79858147
121Abnormality of glycolysis (HP:0004366)1.78782786
122Nephritis (HP:0000123)1.78561583
123Increased purine levels (HP:0004368)1.77097212
124Status epilepticus (HP:0002133)1.70238134
125Pancreatic islet-cell hyperplasia (HP:0004510)1.68971634
126CNS demyelination (HP:0007305)1.68773932
127Megaloblastic anemia (HP:0001889)1.66701592
128Cerebral palsy (HP:0100021)1.65106074
129Increased CSF lactate (HP:0002490)1.60151535
130Pigmentary retinal degeneration (HP:0001146)1.58209828
131Pancreatic cysts (HP:0001737)1.56902138
132Generalized hypopigmentation of hair (HP:0011358)1.54418455
133Decreased central vision (HP:0007663)1.54407860
134Epistaxis (HP:0000421)1.52963615

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.38561355
2PDK26.33863689
3SIK14.55073262
4FGFR44.46493209
5ERN13.79724494
6INSRR3.36362355
7TAOK33.21162168
8WNK33.04893312
9ERBB42.69338748
10WNK42.66381621
11MAP4K22.51918249
12ACVR1B2.45605743
13TLK12.27816428
14MAP2K42.25704221
15MST1R2.12976950
16FLT32.01930039
17PIK3CG1.98666899
18PKN21.98156055
19MAPK111.81574701
20ZAK1.81263410
21CASK1.80976579
22TYK21.76584543
23FRK1.74905194
24ADRBK21.74095536
25DAPK21.60289542
26TNIK1.57797757
27ABL21.55839559
28TESK21.54169237
29NEK91.52667615
30LATS11.52584652
31MAP3K141.49288973
32MUSK1.45868973
33BMPR1B1.44565352
34MAP3K41.44385014
35IRAK31.43361909
36PINK11.41272758
37FGFR21.36272642
38PTK61.33332877
39KDR1.31041149
40STK391.29973779
41STK38L1.27038195
42PNCK1.25627982
43JAK21.17217288
44MAPK131.12906984
45TRIB31.12889957
46NME11.12808695
47TBK11.11236771
48PRKAA21.09980061
49EIF2AK31.07790115
50TIE11.06412364
51MAP2K31.06190965
52MAP3K71.05823369
53OXSR11.05188361
54JAK11.01634371
55MAPK41.01574216
56MAP2K70.99575970
57MAPKAPK30.97613901
58PAK30.97408854
59LMTK20.97237256
60TRIM280.97047893
61GRK60.96442029
62PRKCE0.96151034
63PRKCZ0.93400334
64CDK190.92926536
65STK160.90272319
66PLK20.88886983
67MAP3K30.88019430
68ERBB20.87625794
69SIK20.87216174
70PLK40.86037287
71NTRK30.85464378
72MAPK120.79084737
73SGK30.77078699
74IKBKE0.76242407
75PRKACG0.75543022
76MAP2K60.74208924
77SGK20.73673789
78CDK60.73029719
79MAP3K100.72141598
80MAPK150.71910393
81MAP3K110.71216104
82FER0.71180726
83EPHA30.69994657
84CSNK1D0.69593755
85MET0.69040382
86VRK10.68524547
87MAPK70.68310095
88CSNK1A10.67400513
89MKNK20.67188640
90CSK0.66785886
91GRK10.66623798
92TNK20.65558092
93CAMK2G0.65537735
94BRSK20.64864626
95PRKACA0.64162275
96TAOK20.64156912
97GSK3A0.63680725
98PRKAA10.63563701
99PRKACB0.63526591
100DYRK20.62739893
101CCNB10.62004736
102MAPKAPK50.61699613
103DYRK1B0.61430209
104PRKG10.59732316
105PBK0.59577594
106CSF1R0.58375819
107FGFR30.57944254
108BCR0.56720951
109CAMK1D0.56630059
110IRAK20.55069607
111EPHB10.54944259
112PRKCQ0.54335799
113WEE10.52492446
114IRAK10.49829936
115TGFBR20.49807784
116SGK4940.48336111
117SGK2230.48336111
118MAP3K50.48036514
119IGF1R0.45981003
120NLK0.45896155
121TXK0.45260013
122CSNK1G10.44772447
123PRKCG0.44676251
124CSNK2A10.44583573
125CSNK1A1L0.43355165
126PLK30.42978459
127PDPK10.42894666
128ADRBK10.42583349
129EPHA40.41055096
130CAMKK20.39596180
131CSNK2A20.39219788
132CDK40.39117145
133PRKCB0.38656029
134AKT30.38374184
135PTK20.38042070
136PHKG20.37215395
137PHKG10.37215395
138CSNK1E0.37079823
139CAMK2A0.36709863
140RIPK10.36167910
141PRKCI0.35577506
142TGFBR10.34337016
143MAP2K10.33043969
144PIK3CA0.32836460
145MAP3K60.30337995
146MAP3K130.29986600
147PRKCA0.28640735
148CAMK40.28510704
149PKN10.27885848
150PDK10.26183717
151CHUK0.25594052
152EGFR0.25502767
153KIT0.24941166
154RET0.22837529
155IKBKB0.22362344
156ABL10.21778571
157NUAK10.21370497
158MTOR0.21360742
159MAPK30.21168464
160CSNK1G30.20574856
161CSNK1G20.20083405
162PDK30.19645273

Predicted pathways (KEGG)

RankGene SetZ-score
1* Primary bile acid biosynthesis_Homo sapiens_hsa001204.25528963
2Nitrogen metabolism_Homo sapiens_hsa009103.52819459
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.45771922
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.35101614
5Arginine biosynthesis_Homo sapiens_hsa002203.03000495
6Tryptophan metabolism_Homo sapiens_hsa003802.72519872
7Complement and coagulation cascades_Homo sapiens_hsa046102.69434164
8Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.67722583
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.62104925
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.54819414
11Fatty acid degradation_Homo sapiens_hsa000712.45933209
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.41019358
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.36139856
14Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.27477317
15Butanoate metabolism_Homo sapiens_hsa006502.16474274
16Peroxisome_Homo sapiens_hsa041462.09864496
17Chemical carcinogenesis_Homo sapiens_hsa052042.07669108
18Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.06460090
19Propanoate metabolism_Homo sapiens_hsa006401.96165283
20Histidine metabolism_Homo sapiens_hsa003401.94033290
21* Steroid hormone biosynthesis_Homo sapiens_hsa001401.88964346
22Drug metabolism - other enzymes_Homo sapiens_hsa009831.84301198
23Caffeine metabolism_Homo sapiens_hsa002321.84069341
24PPAR signaling pathway_Homo sapiens_hsa033201.80992876
25Retinol metabolism_Homo sapiens_hsa008301.76851741
26Fatty acid metabolism_Homo sapiens_hsa012121.76792700
27beta-Alanine metabolism_Homo sapiens_hsa004101.76723490
28Staphylococcus aureus infection_Homo sapiens_hsa051501.76042884
29Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.72617958
30Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.72561254
31Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.63470723
32Selenocompound metabolism_Homo sapiens_hsa004501.59727357
33Phenylalanine metabolism_Homo sapiens_hsa003601.59240006
34Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.50765588
352-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.49643555
36Bile secretion_Homo sapiens_hsa049761.47823436
37Tyrosine metabolism_Homo sapiens_hsa003501.44914963
38Sulfur metabolism_Homo sapiens_hsa009201.36581928
39Pyruvate metabolism_Homo sapiens_hsa006201.34607961
40Cysteine and methionine metabolism_Homo sapiens_hsa002701.32056444
41Starch and sucrose metabolism_Homo sapiens_hsa005001.31425902
42Fatty acid elongation_Homo sapiens_hsa000621.30218410
43Folate biosynthesis_Homo sapiens_hsa007901.21324693
44ABC transporters_Homo sapiens_hsa020101.20775752
45Steroid biosynthesis_Homo sapiens_hsa001001.19716456
46Biosynthesis of amino acids_Homo sapiens_hsa012301.18305569
47Carbon metabolism_Homo sapiens_hsa012001.11260768
48Fat digestion and absorption_Homo sapiens_hsa049751.10774146
49Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.06569914
50Cyanoamino acid metabolism_Homo sapiens_hsa004601.03474329
51Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.03252591
52Maturity onset diabetes of the young_Homo sapiens_hsa049501.00644751
53Arginine and proline metabolism_Homo sapiens_hsa003300.99249798
54Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.92738616
55Vitamin B6 metabolism_Homo sapiens_hsa007500.91782226
56Vitamin digestion and absorption_Homo sapiens_hsa049770.91347193
57Sulfur relay system_Homo sapiens_hsa041220.90577521
58One carbon pool by folate_Homo sapiens_hsa006700.81712178
59Lysine degradation_Homo sapiens_hsa003100.80915542
60Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.80127320
61Glutathione metabolism_Homo sapiens_hsa004800.72804578
62Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.68711041
63Glycerolipid metabolism_Homo sapiens_hsa005610.65646655
64Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.58243404
65Pentose phosphate pathway_Homo sapiens_hsa000300.56295055
66Oxidative phosphorylation_Homo sapiens_hsa001900.50403131
67Fatty acid biosynthesis_Homo sapiens_hsa000610.48774269
68* Metabolic pathways_Homo sapiens_hsa011000.47338600
69Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.46932441
70Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.43769989
71Protein export_Homo sapiens_hsa030600.33951690
72Parkinsons disease_Homo sapiens_hsa050120.31183788
73Phototransduction_Homo sapiens_hsa047440.28102814
74Galactose metabolism_Homo sapiens_hsa000520.25740872
75Prion diseases_Homo sapiens_hsa050200.25518362
76alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.25070895
77Linoleic acid metabolism_Homo sapiens_hsa005910.24633471
78Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.24224413
79Fructose and mannose metabolism_Homo sapiens_hsa000510.23624269
80Proteasome_Homo sapiens_hsa030500.21543583
81Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.19989490
82Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.18813904
83Insulin resistance_Homo sapiens_hsa049310.18672004
84Adipocytokine signaling pathway_Homo sapiens_hsa049200.16838240
85Sphingolipid metabolism_Homo sapiens_hsa006000.12560018
86Glycerophospholipid metabolism_Homo sapiens_hsa005640.12079631
87Mineral absorption_Homo sapiens_hsa049780.11117420
88Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.09144873
89Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.08549708
90Glucagon signaling pathway_Homo sapiens_hsa049220.05015585
91Huntingtons disease_Homo sapiens_hsa050160.04526961
92Alzheimers disease_Homo sapiens_hsa050100.04247676
93Ether lipid metabolism_Homo sapiens_hsa00565-0.2548885
94Pyrimidine metabolism_Homo sapiens_hsa00240-0.2542794
95Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.2492826
96Pertussis_Homo sapiens_hsa05133-0.2475833
97Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.2334702
98Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.2316313
99RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622-0.2227866
100Thyroid hormone synthesis_Homo sapiens_hsa04918-0.2218611
101Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.2102108
102Hepatitis C_Homo sapiens_hsa05160-0.1790247
103Renin-angiotensin system_Homo sapiens_hsa04614-0.1708698
104Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1607069
105Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1580069
106African trypanosomiasis_Homo sapiens_hsa05143-0.1485308
107Insulin signaling pathway_Homo sapiens_hsa04910-0.1347710
108Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.1330037
109Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1156104
110Regulation of autophagy_Homo sapiens_hsa04140-0.1080156
111RNA polymerase_Homo sapiens_hsa03020-0.0797203
112Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0512700
113Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0490481
114Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0364726
115AMPK signaling pathway_Homo sapiens_hsa04152-0.0268890
116Other glycan degradation_Homo sapiens_hsa00511-0.0165020
117Serotonergic synapse_Homo sapiens_hsa04726-0.0015747

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