AKR1B10P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cytoplasmic mRNA processing body assembly (GO:0033962)8.84896107
2tricarboxylic acid cycle (GO:0006099)8.81154887
3peptidyl-arginine N-methylation (GO:0035246)8.80537492
4peptidyl-arginine methylation (GO:0018216)8.80537492
5positive regulation of mitochondrial fission (GO:0090141)8.62240925
6histone arginine methylation (GO:0034969)7.87320825
7nerve growth factor signaling pathway (GO:0038180)7.34029667
8regulation of mitochondrial depolarization (GO:0051900)7.21402498
9glomerular visceral epithelial cell development (GO:0072015)7.05825091
10male sex determination (GO:0030238)6.99079742
11pyrimidine deoxyribonucleotide catabolic process (GO:0009223)6.69537989
12pyrimidine nucleotide catabolic process (GO:0006244)6.67143703
13positive regulation of phosphoprotein phosphatase activity (GO:0032516)6.65895250
14positive regulation of B cell differentiation (GO:0045579)6.65129239
15regulation of mitochondrial fission (GO:0090140)6.63024940
16activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO6.57078591
17mitotic cell cycle arrest (GO:0071850)6.39658239
18glomerular epithelial cell development (GO:0072310)6.21145688
19negative regulation of activin receptor signaling pathway (GO:0032926)6.02184969
20protein K6-linked ubiquitination (GO:0085020)5.98854649
21polyketide metabolic process (GO:0030638)5.78148221
22doxorubicin metabolic process (GO:0044598)5.78148221
23daunorubicin metabolic process (GO:0044597)5.78148221
24negative regulation of cell aging (GO:0090344)5.76009643
25base-excision repair, AP site formation (GO:0006285)5.63143339
26peptidyl-arginine modification (GO:0018195)5.59207141
27positive regulation of protein homooligomerization (GO:0032464)5.52832158
28regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)5.47290764
29positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)5.47290764
30regulation of glycogen (starch) synthase activity (GO:2000465)5.34082700
31regulation of protein homooligomerization (GO:0032462)5.25592635
32positive regulation of growth hormone secretion (GO:0060124)5.12717574
33aminoglycoside antibiotic metabolic process (GO:0030647)5.11484100
34muscle organ morphogenesis (GO:0048644)5.00744031
35positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO4.90705281
36regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)4.90705281
37spermatid development (GO:0007286)4.78923193
38lung-associated mesenchyme development (GO:0060484)4.56403664
39positive regulation of mRNA 3-end processing (GO:0031442)4.44635802
40regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902108)4.39697899
41meiosis I (GO:0007127)4.23822298
42response to nerve growth factor (GO:1990089)4.19310983
43cellular response to nerve growth factor stimulus (GO:1990090)4.19310983
44negative regulation of epidermal cell differentiation (GO:0045605)4.14131564
45peristalsis (GO:0030432)4.10262346
46regulation of mRNA 3-end processing (GO:0031440)4.03828894
47sulfation (GO:0051923)3.93793905
48reciprocal DNA recombination (GO:0035825)3.92061838
49reciprocal meiotic recombination (GO:0007131)3.92061838
50regulation of timing of cell differentiation (GO:0048505)3.91189682
51deoxyribonucleotide catabolic process (GO:0009264)3.86847416
52neuronal action potential (GO:0019228)3.86215538
53RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.83175407
54positive regulation of mRNA catabolic process (GO:0061014)3.82166010
55regulation of cell aging (GO:0090342)3.76389171
56sex determination (GO:0007530)3.75493105
57positive regulation of protein oligomerization (GO:0032461)3.61723657
58pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.58078770
59SMAD protein signal transduction (GO:0060395)3.57740125
60fibroblast migration (GO:0010761)3.57374278
61regulation of membrane depolarization (GO:0003254)3.57244172
62deoxyribose phosphate catabolic process (GO:0046386)3.55343418
63positive regulation of phosphatase activity (GO:0010922)3.48120796
64non-recombinational repair (GO:0000726)3.38932635
65double-strand break repair via nonhomologous end joining (GO:0006303)3.38932635
66regulation of development, heterochronic (GO:0040034)3.33502650
67regulation of protein oligomerization (GO:0032459)3.31403430
68primary alcohol catabolic process (GO:0034310)3.29398859
69regulation of mRNA catabolic process (GO:0061013)3.28829062
70regulation of growth hormone secretion (GO:0060123)3.25015840
71negative regulation of protein oligomerization (GO:0032460)3.19626586
72auditory receptor cell stereocilium organization (GO:0060088)3.18706016
73negative regulation of epidermis development (GO:0045683)3.16169060
74exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.15124679
75ER overload response (GO:0006983)3.14381685
76positive regulation of p38MAPK cascade (GO:1900745)3.13727909
77embryonic digestive tract development (GO:0048566)3.12138865
78nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.10475704
79regulation of B cell differentiation (GO:0045577)3.03479262
803-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.00733011
81purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.00733011
82response to redox state (GO:0051775)2.99163007
83B cell homeostasis (GO:0001782)2.98953792
84regulation of Golgi to plasma membrane protein transport (GO:0042996)2.98435638
85multicellular organismal aging (GO:0010259)2.94824964
86nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.92962649
87protein import into peroxisome matrix (GO:0016558)2.92879554
88positive regulation of icosanoid secretion (GO:0032305)2.92266551
89positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.89592247
90mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.89592247
91nucleotide-excision repair, DNA damage removal (GO:0000718)2.82240386
92DNA excision (GO:0044349)2.82240386
93phasic smooth muscle contraction (GO:0014821)2.81231533
94positive regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030949)2.80945830
95positive regulation of mRNA processing (GO:0050685)2.79358893
96protein autoubiquitination (GO:0051865)2.78206003
97positive regulation of fatty acid transport (GO:2000193)2.76983660
98gene silencing by RNA (GO:0031047)2.74920399
99succinate metabolic process (GO:0006105)12.4628254
100peptidyl-arginine omega-N-methylation (GO:0035247)10.0914932

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GATA1_22025678_ChIP-Seq_K562_Human8.10862477
2PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse4.14524783
3CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.91851790
4HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.79131126
5FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.52198493
6ZFP322A_24550733_ChIP-Seq_MESCs_Mouse3.32764295
7E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.03679184
8VDR_22108803_ChIP-Seq_LS180_Human2.85836870
9TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.85623044
10CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.84979366
11CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.09161920
12AUTS2_25519132_ChIP-Seq_293T-REX_Human2.01567010
13STAT6_21828071_ChIP-Seq_BEAS2B_Human10.5237359
14CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.90899056
15BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.90052157
16GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.78524358
17PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.77798370
18ESR1_20079471_ChIP-ChIP_T-47D_Human1.75280698
19IRF1_19129219_ChIP-ChIP_H3396_Human1.70678618
20RUNX1_26923725_Chip-Seq_HPCs_Mouse1.70315836
21DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.62933863
22HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.62110160
23TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.59274663
24PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.56716409
25TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.47817828
26POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.47817828
27NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.47714173
28CBX2_27304074_Chip-Seq_ESCs_Mouse1.45566290
29MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.34789943
30FOXH1_21741376_ChIP-Seq_EPCs_Human1.30575677
31ERA_21632823_ChIP-Seq_H3396_Human1.29657949
32BCOR_27268052_Chip-Seq_Bcells_Human1.26734248
33TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.26536577
34ETV2_25802403_ChIP-Seq_MESCs_Mouse1.25434737
35DNAJC2_21179169_ChIP-ChIP_NT2_Human1.25268199
36MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.22155732
37EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.20570420
38FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.16545294
39GATA6_25053715_ChIP-Seq_YYC3_Human1.13158041
40CDX2_19796622_ChIP-Seq_MESCs_Mouse1.12932962
41CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.12280487
42EGR1_23403033_ChIP-Seq_LIVER_Mouse1.12123893
43ZNF263_19887448_ChIP-Seq_K562_Human1.11459908
44OCT4_20526341_ChIP-Seq_ESCs_Human1.10552507
45SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.09986314
46GF1B_26923725_Chip-Seq_HPCs_Mouse1.08058652
47MYC_19829295_ChIP-Seq_ESCs_Human1.06179493
48BCAT_22108803_ChIP-Seq_LS180_Human1.05804384
49ESR1_15608294_ChIP-ChIP_MCF-7_Human1.05262497
50GBX2_23144817_ChIP-Seq_PC3_Human1.04158771
51FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.03506960
52RAC3_21632823_ChIP-Seq_H3396_Human1.00893743
53NCOR_22424771_ChIP-Seq_293T_Human0.99288981
54TCF4_23295773_ChIP-Seq_U87_Human0.97164250
55FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.96619252
56ESR1_21235772_ChIP-Seq_MCF-7_Human0.96152489
57FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.94528802
58NFI_21473784_ChIP-Seq_ESCs_Mouse0.93202830
59GATA4_25053715_ChIP-Seq_YYC3_Human0.92161399
60ESET_19884257_ChIP-Seq_ESCs_Mouse0.89514903
61CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.89160942
62FOXP3_21729870_ChIP-Seq_TREG_Human0.88572872
63CBP_20019798_ChIP-Seq_JUKART_Human0.88064149
64IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.88064149
65SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.87528806
66SOX2_27498859_Chip-Seq_STOMACH_Mouse0.86171370
67PPARA_22158963_ChIP-Seq_LIVER_Mouse0.85239497
68PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.84363853
69ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.83386713
70SOX2_20726797_ChIP-Seq_SW620_Human0.83307175
71TP53_22573176_ChIP-Seq_HFKS_Human0.82905117
72ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.82747778
73PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.82438376
74SOX2_22085726_ChIP-Seq_NPCs_Mouse0.81828707
75KLF5_20875108_ChIP-Seq_MESCs_Mouse0.81316570
76SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.81182360
77RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.80577299
78RAD21_21589869_ChIP-Seq_MESCs_Mouse0.80514771
79HIF1A_21447827_ChIP-Seq_MCF-7_Human0.78854430
80REST_18959480_ChIP-ChIP_MESCs_Mouse0.78631274
81TET1_21490601_ChIP-Seq_MESCs_Mouse0.78082271
82PADI4_21655091_ChIP-ChIP_MCF-7_Human0.78079290
83RXR_22108803_ChIP-Seq_LS180_Human0.77429951
84REST_21632747_ChIP-Seq_MESCs_Mouse0.75965408
85VDR_23849224_ChIP-Seq_CD4+_Human0.75782520
86CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.75765783
87RARA_24833708_ChIP-Seq_LIVER_Mouse0.75346155
88ERG_20887958_ChIP-Seq_HPC-7_Mouse0.74963186
89SMAD4_21741376_ChIP-Seq_EPCs_Human0.74512046
90BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.74050751
91SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.73459067
92TP53_16413492_ChIP-PET_HCT116_Human0.73337218
93RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.72324661
94CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.70886419
95TAF2_19829295_ChIP-Seq_ESCs_Human0.70749280
96CJUN_26792858_Chip-Seq_BT549_Human0.70683734
97CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.70126241
98E2F1_21310950_ChIP-Seq_MCF-7_Human0.69557013
99ZNF274_21170338_ChIP-Seq_K562_Hela0.69539914
100JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.69483330

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005365_abnormal_bile_salt6.07179316
2MP0005085_abnormal_gallbladder_physiolo4.25941952
3MP0008877_abnormal_DNA_methylation3.67900985
4MP0009780_abnormal_chondrocyte_physiolo2.85171728
5MP0000751_myopathy2.44239324
6MP0009278_abnormal_bone_marrow2.34027620
7MP0003787_abnormal_imprinting2.32534672
8MP0000747_muscle_weakness2.23109562
9MP0003868_abnormal_feces_composition2.20597893
10MP0005058_abnormal_lysosome_morphology2.10740053
11MP0001485_abnormal_pinna_reflex2.06604429
12MP0003567_abnormal_fetal_cardiomyocyte2.06091096
13MP0000749_muscle_degeneration2.01226092
14MP0009764_decreased_sensitivity_to2.00478623
15MP0000566_synostosis10.6289951
16MP0009046_muscle_twitch1.93488405
17MP0003283_abnormal_digestive_organ1.85273685
18MP0002332_abnormal_exercise_endurance1.85192621
19MP0003221_abnormal_cardiomyocyte_apopto1.77976504
20MP0002139_abnormal_hepatobiliary_system1.76001971
21MP0003656_abnormal_erythrocyte_physiolo1.68545110
22MP0001299_abnormal_eye_distance/1.67279281
23MP0008260_abnormal_autophagy1.64855105
24MP0003121_genomic_imprinting1.62621191
25MP0001666_abnormal_nutrient_absorption1.55561534
26MP0006036_abnormal_mitochondrial_physio1.54320852
27MP0008875_abnormal_xenobiotic_pharmacok1.51887727
28MP0003195_calcinosis1.40471060
29MP0002102_abnormal_ear_morphology1.39197082
30MP0002751_abnormal_autonomic_nervous1.38564460
31MP0003122_maternal_imprinting1.38315195
32MP0003806_abnormal_nucleotide_metabolis1.33255328
33MP0005410_abnormal_fertilization1.29543962
34MP0000470_abnormal_stomach_morphology1.27671391
35MP0009053_abnormal_anal_canal1.26145181
36MP0009840_abnormal_foam_cell1.25577932
37MP0000538_abnormal_urinary_bladder1.24942371
38MP0002210_abnormal_sex_determination1.24541827
39MP0001145_abnormal_male_reproductive1.24342122
40MP0000490_abnormal_crypts_of1.24312906
41MP0010386_abnormal_urinary_bladder1.24005731
42MP0000681_abnormal_thyroid_gland1.21795983
43MP0005083_abnormal_biliary_tract1.21302124
44MP0005332_abnormal_amino_acid1.20191174
45MP0004742_abnormal_vestibular_system1.20049926
46MP0001929_abnormal_gametogenesis1.18237889
47MP0005551_abnormal_eye_electrophysiolog1.14906401
48MP0002837_dystrophic_cardiac_calcinosis1.10957699
49MP0000631_abnormal_neuroendocrine_gland1.07421956
50MP0000653_abnormal_sex_gland1.06740071
51MP0005360_urolithiasis0.98747076
52MP0006035_abnormal_mitochondrial_morpho0.97438455
53MP0002111_abnormal_tail_morphology0.95919370
54MP0005646_abnormal_pituitary_gland0.95687777
55MP0004484_altered_response_of0.94224453
56MP0003936_abnormal_reproductive_system0.93551469
57MP0005266_abnormal_metabolism0.90848851
58MP0002932_abnormal_joint_morphology0.89009620
59MP0001944_abnormal_pancreas_morphology0.84985020
60MP0008057_abnormal_DNA_replication0.84881994
61MP0001501_abnormal_sleep_pattern0.84615654
62MP0002735_abnormal_chemical_nociception0.83729963
63MP0004924_abnormal_behavior0.83434792
64MP0005386_behavior/neurological_phenoty0.83434792
65MP0009697_abnormal_copulation0.83197864
66MP0001727_abnormal_embryo_implantation0.81600201
67MP0001756_abnormal_urination0.81308340
68MP0002064_seizures0.79847174
69MP0001664_abnormal_digestion0.77522066
70MP0002938_white_spotting0.75965596
71MP0002653_abnormal_ependyma_morphology0.75962587
72MP0002272_abnormal_nervous_system0.75908826
73MP0000639_abnormal_adrenal_gland0.75667343
74MP0010329_abnormal_lipoprotein_level0.75625870
75MP0005385_cardiovascular_system_phenoty0.75194395
76MP0001544_abnormal_cardiovascular_syste0.75194395
77MP0004782_abnormal_surfactant_physiolog0.74247168
78MP0000372_irregular_coat_pigmentation0.73199140
79MP0003942_abnormal_urinary_system0.69010279
80MP0003698_abnormal_male_reproductive0.68230603
81MP0000477_abnormal_intestine_morphology0.67270530
82MP0004130_abnormal_muscle_cell0.66588330
83MP0005319_abnormal_enzyme/_coenzyme0.64842798
84MP0002733_abnormal_thermal_nociception0.64791303
85MP0003119_abnormal_digestive_system0.63697314
86MP0005369_muscle_phenotype0.62909972
87MP0002160_abnormal_reproductive_system0.62422661
88MP0005389_reproductive_system_phenotype0.61312882
89MP0001968_abnormal_touch/_nociception0.60282859
90MP0002572_abnormal_emotion/affect_behav0.58079960
91MP0001970_abnormal_pain_threshold0.57599778
92MP0003950_abnormal_plasma_membrane0.57212518
93MP0001963_abnormal_hearing_physiology0.56810752
94MP0009745_abnormal_behavioral_response0.56499107
95MP0002138_abnormal_hepatobiliary_system0.56240869
96MP0004197_abnormal_fetal_growth/weight/0.53771658
97MP0002118_abnormal_lipid_homeostasis0.53206728
98MP0005508_abnormal_skeleton_morphology0.52682129
99MP0005584_abnormal_enzyme/coenzyme_acti0.52523152
100MP0008569_lethality_at_weaning0.51437060

Predicted human phenotypes

RankGene SetZ-score
1Absent rod-and cone-mediated responses on ERG (HP:0007688)6.90459796
2Decreased central vision (HP:0007663)5.79527215
3Synostosis involving the elbow (HP:0003938)5.72416079
4Humeroradial synostosis (HP:0003041)5.72416079
5Abnormality of dicarboxylic acid metabolism (HP:0010995)5.32614568
6Dicarboxylic aciduria (HP:0003215)5.32614568
7Unsteady gait (HP:0002317)5.28666121
8Hypophosphatemia (HP:0002148)4.44911830
9Attenuation of retinal blood vessels (HP:0007843)4.10510089
10Abnormal rod and cone electroretinograms (HP:0008323)4.01449403
11Pheochromocytoma (HP:0002666)3.84721081
12Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.63215293
13Tetraparesis (HP:0002273)3.50601149
14Symphalangism affecting the phalanges of the hand (HP:0009773)3.30445459
15Neuroendocrine neoplasm (HP:0100634)3.21311223
16Hypoplasia of the thymus (HP:0000778)3.19124381
17Amblyopia (HP:0000646)3.15965484
18Turricephaly (HP:0000262)3.07216047
19Prolonged neonatal jaundice (HP:0006579)3.06809013
20Cubitus valgus (HP:0002967)3.04651312
21Cerebral hemorrhage (HP:0001342)2.98902876
22Upper limb muscle weakness (HP:0003484)2.89597109
23Clitoromegaly (HP:0000057)2.81750365
24Optic nerve hypoplasia (HP:0000609)2.79859513
25Hand muscle atrophy (HP:0009130)2.71776334
26Conjunctival hamartoma (HP:0100780)2.70193907
27Nonimmune hydrops fetalis (HP:0001790)2.52262470
28Hyperglycinemia (HP:0002154)2.50750081
29Gaze-evoked nystagmus (HP:0000640)2.44991351
30Meningioma (HP:0002858)2.44270149
31Increased serum pyruvate (HP:0003542)2.42924347
32Respiratory failure (HP:0002878)2.38769535
33Febrile seizures (HP:0002373)2.35621879
34Pancreatic cysts (HP:0001737)2.35183633
35Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.32640098
36Pendular nystagmus (HP:0012043)2.32562924
37Short 1st metacarpal (HP:0010034)2.30205145
38Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.30205145
39Abnormality of proline metabolism (HP:0010907)2.27163685
40Hydroxyprolinuria (HP:0003080)2.27163685
41Limb hypertonia (HP:0002509)2.27010017
42Congenital stationary night blindness (HP:0007642)2.25860710
43Steatorrhea (HP:0002570)2.24516670
44Neoplasm of the adrenal gland (HP:0100631)2.24475405
45Bone cyst (HP:0012062)2.23366055
46Abnormality of glycolysis (HP:0004366)2.22047494
47Intellectual disability, severe (HP:0010864)2.20187586
48Oral leukoplakia (HP:0002745)2.19893873
49Hamartoma of the eye (HP:0010568)2.17132813
50Brushfield spots (HP:0001088)2.13556869
51Distal upper limb amyotrophy (HP:0007149)2.12958470
52Upper limb amyotrophy (HP:0009129)2.12958470
53Tubulointerstitial fibrosis (HP:0005576)2.10788057
54Hypoalphalipoproteinemia (HP:0003233)2.07995726
55Abnormality of the 1st metacarpal (HP:0010009)2.06118961
56Respiratory distress (HP:0002098)2.05404336
57Abnormality of the vocal cords (HP:0008777)2.05203150
58Hemiplegia (HP:0002301)2.04043857
59Hyperventilation (HP:0002883)17.3514481
60Methylmalonic aciduria (HP:0012120)11.0901698
61Focal motor seizures (HP:0011153)1.99510718
62Insulin-resistant diabetes mellitus (HP:0000831)1.97181966
63Decreased electroretinogram (ERG) amplitude (HP:0000654)1.97004114
64Hyperhidrosis (HP:0000975)1.95010314
65Synostosis involving bones of the lower limbs (HP:0009138)1.93944879
66Synostosis involving bones of the feet (HP:0009140)1.93944879
67Abnormality of fatty-acid metabolism (HP:0004359)1.91925239
68Cystic liver disease (HP:0006706)1.91128177
69Hyperglycinuria (HP:0003108)1.87930681
70Amelogenesis imperfecta (HP:0000705)1.83157212
71Lactic acidosis (HP:0003128)1.83007876
72Abnormality of glycine metabolism (HP:0010895)1.82620221
73Abnormality of serine family amino acid metabolism (HP:0010894)1.82620221
74Furrowed tongue (HP:0000221)1.82270435
75Bony spicule pigmentary retinopathy (HP:0007737)1.81405406
76Supernumerary spleens (HP:0009799)1.79977348
77Long foot (HP:0001833)1.78565979
78Pancreatic fibrosis (HP:0100732)1.77921488
79Abnormality of glutamine family amino acid metabolism (HP:0010902)1.72475128
80Epileptic encephalopathy (HP:0200134)1.71993532
81Fat malabsorption (HP:0002630)1.70488534
82Confusion (HP:0001289)1.68532310
83Palpebral edema (HP:0100540)1.67437410
84Neoplasm of the peripheral nervous system (HP:0100007)1.65028265
85Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.63771043
86Type II lissencephaly (HP:0007260)1.63339882
87Hyperglycemia (HP:0003074)1.58038262
88Enlarged kidneys (HP:0000105)1.57294198
89Pili torti (HP:0003777)1.56778536
90Abnormal biliary tract morphology (HP:0012440)1.54514580
91Abnormal biliary tract physiology (HP:0012439)1.52111379
92Bile duct proliferation (HP:0001408)1.52111379
93Synostosis involving bones of the hand (HP:0004278)1.51460429
94Severe visual impairment (HP:0001141)1.49822528
95Abnormality of the clitoris (HP:0000056)1.49156745
96Polar cataract (HP:0010696)1.45151458
97Progressive inability to walk (HP:0002505)1.44519162
98Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.44494244
99Long clavicles (HP:0000890)1.43636571
100Ketosis (HP:0001946)1.43324650

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK86.87037459
2MAP3K46.81567644
3MST1R3.44472015
4DYRK1B2.99981229
5GRK72.95345047
6CSNK1G32.86256799
7CSNK1A1L2.84710819
8ZAK2.79261532
9CASK2.53545025
10TGFBR22.50469502
11MOS2.47023723
12GRK52.40764769
13CSNK1G22.38416352
14DYRK32.28784311
15CSNK1G12.23688028
16MST42.15211928
17FRK2.07735076
18VRK21.98882704
19CDK191.95224842
20STK101.92001336
21BRD41.60522157
22MET1.40845994
23SMG11.35811576
24MARK11.30137991
25MAP2K71.26790020
26KDR1.21932693
27NUAK11.15462510
28STK38L1.12270458
29TAF11.10641734
30TLK11.05277891
31PRKCI0.92054658
32EIF2AK20.91364961
33CLK10.91166431
34MAP3K70.85183058
35GRK10.83734102
36BLK0.83686826
37PKN10.79933140
38RPS6KA60.73129256
39DYRK20.72199028
40TRIB30.71832426
41STK110.68147789
42VRK10.67469983
43LIMK10.65545417
44CAMK40.65355091
45OBSCN0.65353611
46IRAK30.65243886
47MAP3K130.64680804
48ERN10.62320297
49EPHA20.57640294
50ERBB40.56646947
51DAPK20.56252198
52RPS6KA50.51135370
53MAP4K10.50588272
54MAPK70.49949577
55NME10.43967999
56TTK0.42750208
57AURKA0.40985863
58PHKG10.40358318
59PHKG20.40358318
60CAMKK20.40014718
61STK40.39749717
62MAPK120.37740315
63ADRBK10.37622772
64STK30.37317992
65TIE10.36974472
66MELK0.36349314
67TBK10.36289641
68LMTK20.34836792
69CDK90.34574497
70CSF1R0.34325587
71PINK10.34110485
72PTK20.31748843
73MAPKAPK50.30784852
74PDK20.30604872
75HIPK20.29175860
76ILK0.28888198
77CSNK1D0.28316508
78CAMK2A0.27863742
79DYRK1A0.26501850
80MARK30.26396906
81MAP3K80.25375028
82PDK10.25051385
83PRKCZ0.20333746
84STK380.19457899
85CSNK1A10.19290578
86MAP2K40.18860993
87BRSK10.18506030
88CSNK2A10.18146239
89TXK0.17729706
90MUSK0.17312015
91IRAK40.17280155
92CAMK10.17237569
93MAPK80.16926054
94MKNK20.16810350
95CHEK20.15662211
96DAPK30.14970694
97CAMK2D0.14217231
98PRKCG0.14160042
99TTN0.13756646
100PRKAA20.13716260

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000208.76679582
2Propanoate metabolism_Homo sapiens_hsa006405.60650299
32-Oxocarboxylic acid metabolism_Homo sapiens_hsa012104.21835313
4Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.95661596
5Carbon metabolism_Homo sapiens_hsa012002.78430800
6Maturity onset diabetes of the young_Homo sapiens_hsa049502.74905053
7Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.31290641
8Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.02692964
9Galactose metabolism_Homo sapiens_hsa000522.00658419
10Cyanoamino acid metabolism_Homo sapiens_hsa004601.86012531
11Pentose and glucuronate interconversions_Homo sapiens_hsa000401.85737228
12Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.72439700
13Proteasome_Homo sapiens_hsa030501.63307298
14Mismatch repair_Homo sapiens_hsa034301.59176369
15Steroid hormone biosynthesis_Homo sapiens_hsa001401.56018944
16Nucleotide excision repair_Homo sapiens_hsa034201.54117336
17Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.20300297
18Retinol metabolism_Homo sapiens_hsa008301.19035900
19Fat digestion and absorption_Homo sapiens_hsa049751.16955129
20Chemical carcinogenesis_Homo sapiens_hsa052041.15695325
21Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.14626981
22Base excision repair_Homo sapiens_hsa034101.13668917
23Starch and sucrose metabolism_Homo sapiens_hsa005001.12948458
24Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.12718741
25Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.11265413
26ABC transporters_Homo sapiens_hsa020101.09044912
27Pancreatic secretion_Homo sapiens_hsa049721.08579779
28Oxidative phosphorylation_Homo sapiens_hsa001901.06542583
29Fructose and mannose metabolism_Homo sapiens_hsa000511.04982739
30Phenylalanine metabolism_Homo sapiens_hsa003601.03439049
31RNA degradation_Homo sapiens_hsa030181.03274666
32Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.91393117
33Arachidonic acid metabolism_Homo sapiens_hsa005900.91089403
34Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.86807332
35Glycerolipid metabolism_Homo sapiens_hsa005610.86336519
36Homologous recombination_Homo sapiens_hsa034400.83525341
37Drug metabolism - other enzymes_Homo sapiens_hsa009830.83013240
38beta-Alanine metabolism_Homo sapiens_hsa004100.81467604
39Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.81362698
40Protein digestion and absorption_Homo sapiens_hsa049740.80882057
41Fanconi anemia pathway_Homo sapiens_hsa034600.80154169
42Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.77722721
43Biosynthesis of amino acids_Homo sapiens_hsa012300.74674407
44Huntingtons disease_Homo sapiens_hsa050160.73121814
45Nitrogen metabolism_Homo sapiens_hsa009100.72200326
46Parkinsons disease_Homo sapiens_hsa050120.70021849
47Linoleic acid metabolism_Homo sapiens_hsa005910.69997731
48Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.69804702
49Alzheimers disease_Homo sapiens_hsa050100.68817431
50Pyrimidine metabolism_Homo sapiens_hsa002400.68258714
51Bile secretion_Homo sapiens_hsa049760.66226287
52Peroxisome_Homo sapiens_hsa041460.66048186
53Arginine and proline metabolism_Homo sapiens_hsa003300.63920081
54Phototransduction_Homo sapiens_hsa047440.63566125
55Vitamin digestion and absorption_Homo sapiens_hsa049770.62035525
56Sphingolipid signaling pathway_Homo sapiens_hsa040710.61694015
57Tyrosine metabolism_Homo sapiens_hsa003500.61394056
58Glutathione metabolism_Homo sapiens_hsa004800.60564364
59Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.59274446
60alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.58636409
61Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.57985935
62Arginine biosynthesis_Homo sapiens_hsa002200.55673477
63Caffeine metabolism_Homo sapiens_hsa002320.53828583
64Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.53595863
65One carbon pool by folate_Homo sapiens_hsa006700.51705025
66Metabolic pathways_Homo sapiens_hsa011000.51615126
67Basal transcription factors_Homo sapiens_hsa030220.50346268
68RNA polymerase_Homo sapiens_hsa030200.46832196
69Fatty acid degradation_Homo sapiens_hsa000710.46587914
70Melanoma_Homo sapiens_hsa052180.46133470
71AMPK signaling pathway_Homo sapiens_hsa041520.45516583
72Tight junction_Homo sapiens_hsa045300.42447839
73Ovarian steroidogenesis_Homo sapiens_hsa049130.40342363
74Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.39162579
75mRNA surveillance pathway_Homo sapiens_hsa030150.38901427
76Dopaminergic synapse_Homo sapiens_hsa047280.37086769
77Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.36880832
78Mineral absorption_Homo sapiens_hsa049780.35162719
79Glycerophospholipid metabolism_Homo sapiens_hsa005640.33820868
80Ether lipid metabolism_Homo sapiens_hsa005650.33490740
81Purine metabolism_Homo sapiens_hsa002300.33437349
82Intestinal immune network for IgA production_Homo sapiens_hsa046720.33163418
83Pentose phosphate pathway_Homo sapiens_hsa000300.31420644
84Tryptophan metabolism_Homo sapiens_hsa003800.30227402
85Cardiac muscle contraction_Homo sapiens_hsa042600.30095126
86Rap1 signaling pathway_Homo sapiens_hsa040150.27930821
87Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.27076775
88Apoptosis_Homo sapiens_hsa042100.26603361
89Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.26511822
90Other glycan degradation_Homo sapiens_hsa005110.24837569
91Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.24455272
92Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.23557865
93Folate biosynthesis_Homo sapiens_hsa007900.22670416
94Regulation of autophagy_Homo sapiens_hsa041400.21923642
95Cell cycle_Homo sapiens_hsa041100.21179162
96DNA replication_Homo sapiens_hsa030300.20823059
97Sphingolipid metabolism_Homo sapiens_hsa006000.19611173
98Small cell lung cancer_Homo sapiens_hsa052220.18902280
99Renin-angiotensin system_Homo sapiens_hsa046140.17375509
100Systemic lupus erythematosus_Homo sapiens_hsa053220.16612357

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