AKNA

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)7.51856311
2negative regulation of cell killing (GO:0031342)6.05018447
3negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.05018447
4antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.95968425
5antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.95968425
6regulation of gamma-delta T cell differentiation (GO:0045586)5.73723525
7antigen processing and presentation of endogenous antigen (GO:0019883)5.71830867
8negative T cell selection (GO:0043383)5.55328569
9regulation of gamma-delta T cell activation (GO:0046643)5.49921036
10positive thymic T cell selection (GO:0045059)5.49165247
11negative thymic T cell selection (GO:0045060)5.48117496
12regulation of B cell receptor signaling pathway (GO:0050855)5.11317750
13positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.09077319
14leukocyte aggregation (GO:0070486)4.88405272
15response to interleukin-15 (GO:0070672)4.85294515
16positive T cell selection (GO:0043368)4.82165957
17thymic T cell selection (GO:0045061)4.66270087
18T cell migration (GO:0072678)4.58885218
19T cell selection (GO:0045058)4.54377252
20cellular response to interleukin-15 (GO:0071350)4.52146708
21detection of other organism (GO:0098543)4.45023391
22regulation of interleukin-12 biosynthetic process (GO:0045075)4.44615998
23B cell receptor signaling pathway (GO:0050853)4.40308983
24detection of bacterium (GO:0016045)4.40209907
25regulation of B cell differentiation (GO:0045577)4.37862942
26positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.37475623
27tolerance induction (GO:0002507)4.35886352
28negative regulation of lymphocyte mediated immunity (GO:0002707)4.34891203
29interferon-gamma production (GO:0032609)4.34317597
30positive regulation of B cell differentiation (GO:0045579)4.23799500
31neutrophil activation involved in immune response (GO:0002283)4.20425880
32macrophage activation involved in immune response (GO:0002281)4.20365421
33regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)4.02010261
34regulation of T cell tolerance induction (GO:0002664)3.92510752
35regulation of isotype switching to IgG isotypes (GO:0048302)3.91223945
36antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.90005152
37NIK/NF-kappaB signaling (GO:0038061)3.87997644
38negative regulation of leukocyte mediated immunity (GO:0002704)3.87886248
39regulation of alpha-beta T cell proliferation (GO:0046640)3.82891551
40antigen receptor-mediated signaling pathway (GO:0050851)3.78255200
41T cell receptor signaling pathway (GO:0050852)3.72582150
42regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.67513801
43activated T cell proliferation (GO:0050798)3.65466241
44positive regulation of isotype switching (GO:0045830)3.60535074
45detection of external biotic stimulus (GO:0098581)3.59358877
46T cell costimulation (GO:0031295)3.56798969
47positive regulation of interleukin-2 production (GO:0032743)3.54496689
48lymphocyte costimulation (GO:0031294)3.49948056
49positive regulation of granulocyte differentiation (GO:0030854)3.49051178
50respiratory burst (GO:0045730)3.46998263
51response to peptidoglycan (GO:0032494)3.46055010
52leukocyte cell-cell adhesion (GO:0007159)3.43645837
53negative regulation of erythrocyte differentiation (GO:0045647)3.43451101
54negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.42054948
55regulation of interleukin-2 biosynthetic process (GO:0045076)3.38781377
56myeloid cell activation involved in immune response (GO:0002275)3.38085117
57positive regulation of alpha-beta T cell proliferation (GO:0046641)3.36508149
58positive regulation of tolerance induction (GO:0002645)3.27715677
59T cell homeostasis (GO:0043029)3.27175206
60regulation of T cell mediated cytotoxicity (GO:0001914)3.26826106
61response to host immune response (GO:0052572)3.25787986
62response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.25787986
63response to muramyl dipeptide (GO:0032495)3.22375767
64microglial cell activation (GO:0001774)3.21699075
65JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.20472808
66cellular extravasation (GO:0045123)3.18064651
67lymphocyte homeostasis (GO:0002260)3.17903595
68regulation of T cell receptor signaling pathway (GO:0050856)3.16606824
69myeloid dendritic cell activation (GO:0001773)3.16048293
70negative regulation of interleukin-12 production (GO:0032695)3.15491199
71detection of biotic stimulus (GO:0009595)3.15178141
72positive regulation of T cell mediated cytotoxicity (GO:0001916)3.13819223
73regulation of tolerance induction (GO:0002643)3.12687859
74regulation of type I interferon-mediated signaling pathway (GO:0060338)3.10184948
75positive regulation of humoral immune response (GO:0002922)3.09913678
76immunoglobulin mediated immune response (GO:0016064)3.09524351
77mature B cell differentiation (GO:0002335)3.08303863
78positive regulation of DNA recombination (GO:0045911)3.08136047
79regulation of mast cell degranulation (GO:0043304)3.07879003
80mast cell activation (GO:0045576)3.07490241
81regulation of dendritic cell antigen processing and presentation (GO:0002604)3.07295003
82response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.07127750
83response to host (GO:0075136)3.07127750
84response to host defenses (GO:0052200)3.07127750
85interferon-gamma-mediated signaling pathway (GO:0060333)3.07062855
86regulation of response to interferon-gamma (GO:0060330)3.06817968
87T cell proliferation (GO:0042098)3.06642032
88detection of molecule of bacterial origin (GO:0032490)3.05819798
89natural killer cell activation (GO:0030101)3.05089019
90regulation of natural killer cell mediated immunity (GO:0002715)3.04576832
91regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.04576832
92negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.04528945
93leukocyte degranulation (GO:0043299)3.04315196
94B cell homeostasis (GO:0001782)3.04164119
95neutrophil activation (GO:0042119)3.03387771
96negative regulation of T cell mediated immunity (GO:0002710)3.02745330
97regulation of interferon-gamma-mediated signaling pathway (GO:0060334)3.02567107
98negative regulation of innate immune response (GO:0045824)3.00671203
99positive regulation of immunoglobulin mediated immune response (GO:0002891)2.99776921
100positive regulation of B cell mediated immunity (GO:0002714)2.99776921
101positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.98901359
102cellular response to zinc ion (GO:0071294)2.97711860
103regulation of regulatory T cell differentiation (GO:0045589)2.97134763
104positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.97063279
105antigen processing and presentation via MHC class Ib (GO:0002475)2.96927801
106negative regulation of T-helper cell differentiation (GO:0045623)2.96922058
107negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.96922058
108immune response-activating cell surface receptor signaling pathway (GO:0002429)2.96023525
109regulation of isotype switching (GO:0045191)2.95800809
110macrophage activation (GO:0042116)2.95078440
111defense response to protozoan (GO:0042832)2.94613951
112response to type I interferon (GO:0034340)2.94112203
113natural killer cell differentiation (GO:0001779)2.93329959
114positive regulation of B cell activation (GO:0050871)2.92213800
115positive regulation by symbiont of host defense response (GO:0052509)2.91769386
116modulation by symbiont of host defense response (GO:0052031)2.91769386
117modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.91769386
118modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.91769386
119positive regulation by organism of defense response of other organism involved in symbiotic interact2.91769386
120modulation by symbiont of host immune response (GO:0052553)2.91769386
121regulation of interferon-beta biosynthetic process (GO:0045357)2.90873259
122response to protozoan (GO:0001562)2.89412026
123negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.88832014
124germinal center formation (GO:0002467)2.87921148
125type I interferon signaling pathway (GO:0060337)2.87511715
126cellular response to type I interferon (GO:0071357)2.87511715
127regulation of granulocyte differentiation (GO:0030852)2.87359976
128regulation of myeloid leukocyte mediated immunity (GO:0002886)2.87128243
129negative regulation of phagocytosis (GO:0050765)2.86580493
130myeloid dendritic cell differentiation (GO:0043011)2.85912586
131positive regulation of antigen processing and presentation (GO:0002579)2.85257805
132positive regulation of mast cell activation (GO:0033005)2.84823612
133B cell proliferation (GO:0042100)2.84384432
134negative regulation of adaptive immune response (GO:0002820)2.84240856
135positive regulation of immunoglobulin production (GO:0002639)2.82775756
136granulocyte activation (GO:0036230)2.80264773

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.94943818
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.21931330
3IRF8_22096565_ChIP-ChIP_GC-B_Human4.85161578
4IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.83676750
5MYC_22102868_ChIP-Seq_BL_Human3.73888592
6IRF8_21731497_ChIP-ChIP_J774_Mouse3.62106486
7E2F7_22180533_ChIP-Seq_HELA_Human3.50473729
8* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.42357153
9STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.29889064
10EGR1_19374776_ChIP-ChIP_THP-1_Human3.11797376
11SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.11702323
12* RUNX_20019798_ChIP-Seq_JUKART_Human3.09296568
13* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse3.08730544
14VDR_21846776_ChIP-Seq_THP-1_Human2.98038659
15IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.93048319
16* MYB_26560356_Chip-Seq_TH2_Human2.91788961
17STAT4_19710469_ChIP-ChIP_TH1__Mouse2.88844698
18* IRF8_27001747_Chip-Seq_BMDM_Mouse2.79415185
19MAF_26560356_Chip-Seq_TH1_Human2.79195259
20SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.74419959
21NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.71482601
22MYB_26560356_Chip-Seq_TH1_Human2.61150366
23UTX_26944678_Chip-Seq_JUKART_Human2.48955303
24* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.48324560
25SCL_19346495_ChIP-Seq_HPC-7_Human2.45279308
26BP1_19119308_ChIP-ChIP_Hs578T_Human2.43819609
27MYB_21317192_ChIP-Seq_ERMYB_Mouse2.38407710
28* TCF7_22412390_ChIP-Seq_EML_Mouse2.22440306
29RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.19983698
30SPI1_23547873_ChIP-Seq_NB4_Human2.19666853
31VDR_24763502_ChIP-Seq_THP-1_Human2.17558522
32* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.15593728
33SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.11182153
34ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.10241444
35* RUNX1_22412390_ChIP-Seq_EML_Mouse2.04988322
36BRD4_27068464_Chip-Seq_AML-cells_Mouse2.04420043
37* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.96679500
38VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.93629573
39FOXM1_23109430_ChIP-Seq_U2OS_Human1.91015607
40MAF_26560356_Chip-Seq_TH2_Human1.83679284
41SPI1_23127762_ChIP-Seq_K562_Human1.81367593
42* GATA3_27048872_Chip-Seq_THYMUS_Human1.78508982
43KDM2B_26808549_Chip-Seq_DND41_Human1.76514848
44STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.72085259
45KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.71277955
46NOTCH1_21737748_ChIP-Seq_TLL_Human1.69508452
47KDM2B_26808549_Chip-Seq_SUP-B15_Human1.63322075
48RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.61988075
49MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.61057242
50FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.60078144
51NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.59286337
52CIITA_25753668_ChIP-Seq_RAJI_Human1.55492004
53PU_27001747_Chip-Seq_BMDM_Mouse1.43669747
54GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.40446972
55SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.38936936
56PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.37042273
57TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.35361642
58GATA2_22383799_ChIP-Seq_G1ME_Mouse1.34900623
59* ELK3_25401928_ChIP-Seq_HUVEC_Human1.29284419
60STAT6_21828071_ChIP-Seq_BEAS2B_Human1.26590049
61SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.26260551
62ELF1_17652178_ChIP-ChIP_JURKAT_Human1.25518304
63NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.23615610
64LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.23118113
65TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.22698008
66* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.20303581
67GATA3_26560356_Chip-Seq_TH2_Human1.17415918
68VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.17278406
69SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.14642130
70RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.11482701
71GATA1_22383799_ChIP-Seq_G1ME_Mouse1.11365472
72Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.10037164
73GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.10002338
74* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.09842334
75BCL6_27268052_Chip-Seq_Bcells_Human1.07635243
76CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.07530596
77IKZF1_21737484_ChIP-ChIP_HCT116_Human1.07409652
78TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.05854736
79GATA1_19941827_ChIP-Seq_MEL_Mouse1.04487152
80* KDM2B_26808549_Chip-Seq_JURKAT_Human1.03423239
81BCOR_27268052_Chip-Seq_Bcells_Human1.00846842
82GATA1_22025678_ChIP-Seq_K562_Human1.00328160
83PU.1_20513432_ChIP-Seq_Bcells_Mouse0.97287931
84VDR_24787735_ChIP-Seq_THP-1_Human0.95463222
85E2F4_17652178_ChIP-ChIP_JURKAT_Human0.94412780
86ERG_20887958_ChIP-Seq_HPC-7_Mouse0.93191187
87CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.91251478
88NCOR1_26117541_ChIP-Seq_K562_Human0.91242545
89GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.91070237
90BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.90367390
91SMAD_19615063_ChIP-ChIP_OVARY_Human0.89259799
92* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.89151985
93CTCF_27219007_Chip-Seq_ERYTHROID_Human0.88848422
94THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.86790724
95LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.86757121
96CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.86539397
97HOXB4_20404135_ChIP-ChIP_EML_Mouse0.85968412
98SA1_27219007_Chip-Seq_ERYTHROID_Human0.85237328
99ELF1_20517297_ChIP-Seq_JURKAT_Human0.84721957
100GATA2_21666600_ChIP-Seq_HMVEC_Human0.84443303
101PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.84359546
102RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.80351164
103PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.80262293
104PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.74435095
105SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.73775420
106EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.73493261
107FOXP3_21729870_ChIP-Seq_TREG_Human0.73105048
108LXR_22292898_ChIP-Seq_THP-1_Human0.72955778
109GATA1_19941826_ChIP-Seq_K562_Human0.72421971
110* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.70036478
111GATA2_19941826_ChIP-Seq_K562_Human0.70025999
112* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.69120321
113VDR_23849224_ChIP-Seq_CD4+_Human0.69045842
114TFEB_21752829_ChIP-Seq_HELA_Human0.66936338

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.16974634
2MP0005671_abnormal_response_to3.77737193
3MP0003763_abnormal_thymus_physiology3.68181683
4MP0000685_abnormal_immune_system3.64010481
5MP0001800_abnormal_humoral_immune3.54144721
6MP0001790_abnormal_immune_system3.41060942
7MP0005387_immune_system_phenotype3.41060942
8MP0005000_abnormal_immune_tolerance3.04645385
9MP0002452_abnormal_antigen_presenting2.99270595
10MP0002723_abnormal_immune_serum2.91404688
11MP0002420_abnormal_adaptive_immunity2.88987334
12MP0003436_decreased_susceptibility_to2.86249540
13MP0001819_abnormal_immune_cell2.85481908
14MP0003303_peritoneal_inflammation2.82591190
15MP0009785_altered_susceptibility_to2.81652342
16MP0002398_abnormal_bone_marrow2.72606672
17MP0002396_abnormal_hematopoietic_system2.57587202
18MP0005025_abnormal_response_to2.56913286
19MP0000716_abnormal_immune_system2.44631828
20MP0002166_altered_tumor_susceptibility2.40395394
21MP0002419_abnormal_innate_immunity2.40394272
22MP0002405_respiratory_system_inflammati2.38379369
23MP0001873_stomach_inflammation2.38013289
24MP0000689_abnormal_spleen_morphology2.22712587
25MP0002148_abnormal_hypersensitivity_rea2.21424937
26MP0003300_gastrointestinal_ulcer2.20486776
27MP0009333_abnormal_splenocyte_physiolog2.20253297
28MP0002722_abnormal_immune_system2.16628495
29MP0006082_CNS_inflammation2.15762240
30MP0000703_abnormal_thymus_morphology2.12315643
31MP0010155_abnormal_intestine_physiology2.05242990
32MP0002006_tumorigenesis2.02035270
33MP0002429_abnormal_blood_cell2.01769646
34MP0004947_skin_inflammation1.98984137
35MP0004510_myositis1.96151224
36MP0005464_abnormal_platelet_physiology1.95422907
37MP0004808_abnormal_hematopoietic_stem1.89093331
38MP0009278_abnormal_bone_marrow1.81415458
39MP0001845_abnormal_inflammatory_respons1.79416191
40MP0001853_heart_inflammation1.76878289
41MP0003866_abnormal_defecation1.72198432
42MP0008260_abnormal_autophagy1.60318021
43MP0002933_joint_inflammation1.55435768
44MP0003724_increased_susceptibility_to1.52742586
45MP0005397_hematopoietic_system_phenotyp1.47131582
46MP0001545_abnormal_hematopoietic_system1.47131582
47MP0000465_gastrointestinal_hemorrhage1.39596339
48MP0000569_abnormal_digit_pigmentation1.38680737
49MP0005451_abnormal_body_composition1.36256824
50MP0005310_abnormal_salivary_gland1.30636101
51MP0000858_altered_metastatic_potential1.29686261
52MP0003448_altered_tumor_morphology1.28916569
53MP0001533_abnormal_skeleton_physiology1.27731636
54MP0005174_abnormal_tail_pigmentation1.24619219
55MP0008469_abnormal_protein_level1.21843470
56MP0003183_abnormal_peptide_metabolism1.19249366
57MP0004883_abnormal_blood_vessel1.18664314
58MP0005076_abnormal_cell_differentiation1.17936242
59MP0000490_abnormal_crypts_of1.16972954
60MP0003172_abnormal_lysosome_physiology1.13237848
61MP0010352_gastrointestinal_tract_polyps1.10923567
62MP0002019_abnormal_tumor_incidence1.02709010
63MP0008057_abnormal_DNA_replication0.96926895
64MP0001851_eye_inflammation0.96698816
65MP0001986_abnormal_taste_sensitivity0.95994832
66MP0003690_abnormal_glial_cell0.91194918
67MP0005075_abnormal_melanosome_morpholog0.90068819
68MP0002998_abnormal_bone_remodeling0.89179701
69MP0010307_abnormal_tumor_latency0.87023860
70MP0008961_abnormal_basal_metabolism0.85113308
71MP0003077_abnormal_cell_cycle0.82423093
72MP0000015_abnormal_ear_pigmentation0.81205516
73MP0003045_fibrosis0.80836521
74MP0009764_decreased_sensitivity_to0.78916846
75MP0005164_abnormal_response_to0.78870825
76MP0005058_abnormal_lysosome_morphology0.78388345
77MP0003091_abnormal_cell_migration0.76680240
78MP0002138_abnormal_hepatobiliary_system0.75545390
79MP0005023_abnormal_wound_healing0.75213993
80MP0004130_abnormal_muscle_cell0.73762928
81MP0002009_preneoplasia0.71577801
82MP0010094_abnormal_chromosome_stability0.68708734
83MP0009763_increased_sensitivity_to0.67624983
84MP0002132_abnormal_respiratory_system0.66143510
85MP0000371_diluted_coat_color0.63075396
86MP0003693_abnormal_embryo_hatching0.62307977
87MP0003075_altered_response_to0.62286587
88MP0005166_decreased_susceptibility_to0.62193257
89MP0003566_abnormal_cell_adhesion0.62159646
90MP0003453_abnormal_keratinocyte_physiol0.62086174
91MP0001663_abnormal_digestive_system0.61055820
92MP0003828_pulmonary_edema0.60472157
93MP0000604_amyloidosis0.59952297
94MP0002136_abnormal_kidney_physiology0.59374873
95MP0003191_abnormal_cellular_cholesterol0.58105331
96MP0002928_abnormal_bile_duct0.58096445
97MP0000313_abnormal_cell_death0.58001444
98MP0008007_abnormal_cellular_replicative0.57396146
99MP0000343_altered_response_to0.55470093
100MP0000249_abnormal_blood_vessel0.55209638
101MP0004381_abnormal_hair_follicle0.54969240
102MP0000350_abnormal_cell_proliferation0.54966491
103MP0002693_abnormal_pancreas_physiology0.54558355
104MP0008004_abnormal_stomach_pH0.54052022
105MP0009765_abnormal_xenobiotic_induced0.52422675
106MP0003795_abnormal_bone_structure0.52409330
107MP0005381_digestive/alimentary_phenotyp0.52406914
108MP0009115_abnormal_fat_cell0.50675821
109MP0008874_decreased_physiological_sensi0.50346147
110MP0002095_abnormal_skin_pigmentation0.50180201
111MP0002277_abnormal_respiratory_mucosa0.50160059
112MP0003656_abnormal_erythrocyte_physiolo0.50083205
113MP0005390_skeleton_phenotype0.49059233
114MP0008058_abnormal_DNA_repair0.48704552
115MP0005621_abnormal_cell_physiology0.48609305
116MP0001348_abnormal_lacrimal_gland0.44081891
117MP0002133_abnormal_respiratory_system0.40694158
118MP0005388_respiratory_system_phenotype0.40694158
119MP0000609_abnormal_liver_physiology0.39984851

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)4.85585318
2Recurrent viral infections (HP:0004429)4.76174020
3Recurrent bronchitis (HP:0002837)4.71243509
4Abnormality of T cell number (HP:0011839)4.69445813
5Recurrent abscess formation (HP:0002722)4.65755129
6Recurrent fungal infections (HP:0002841)4.63091253
7Eczematoid dermatitis (HP:0000976)4.49328532
8Elevated erythrocyte sedimentation rate (HP:0003565)4.47270712
9Chronic otitis media (HP:0000389)4.29719170
10Agammaglobulinemia (HP:0004432)4.29711136
11Myositis (HP:0100614)4.26057753
12Panhypogammaglobulinemia (HP:0003139)4.21065735
13IgM deficiency (HP:0002850)4.16996821
14Abnormal delayed hypersensitivity skin test (HP:0002963)4.10337240
15Recurrent bacterial skin infections (HP:0005406)4.07659847
16Nasal polyposis (HP:0100582)3.92275279
17Meningitis (HP:0001287)3.85995851
18Inflammation of the large intestine (HP:0002037)3.85623215
19Abnormality of T cells (HP:0002843)3.84674951
20Abnormality of the fingertips (HP:0001211)3.79567549
21Recurrent cutaneous fungal infections (HP:0011370)3.75932376
22Chronic mucocutaneous candidiasis (HP:0002728)3.75932376
23Gastrointestinal inflammation (HP:0004386)3.73001336
24Colitis (HP:0002583)3.67783307
25Stomatitis (HP:0010280)3.64924086
26Mediastinal lymphadenopathy (HP:0100721)3.61905544
27Cellulitis (HP:0100658)3.56933223
28Vasculitis (HP:0002633)3.51291679
29Retrobulbar optic neuritis (HP:0100654)3.49043212
30Optic neuritis (HP:0100653)3.49043212
31B lymphocytopenia (HP:0010976)3.37696549
32Abnormality of B cell number (HP:0010975)3.37696549
33Severe combined immunodeficiency (HP:0004430)3.37502479
34Pustule (HP:0200039)3.36709274
35Lymphopenia (HP:0001888)3.35316383
36Thyroiditis (HP:0100646)3.35031711
37Abnormality of the nasal mucosa (HP:0000433)3.31046552
38Verrucae (HP:0200043)3.26300845
39Papilloma (HP:0012740)3.26300845
40Abnormality of cells of the lymphoid lineage (HP:0012140)3.26269191
41Combined immunodeficiency (HP:0005387)3.25970145
42Recurrent skin infections (HP:0001581)3.25702401
43Recurrent sinusitis (HP:0011108)3.25573936
44Orchitis (HP:0100796)3.25061008
45Autoimmune thrombocytopenia (HP:0001973)3.19903568
46Eosinophilia (HP:0001880)3.12230435
47Chronic obstructive pulmonary disease (HP:0006510)3.03388085
48Obstructive lung disease (HP:0006536)3.03388085
49Leukocytosis (HP:0001974)2.99995890
50Hypochromic anemia (HP:0001931)2.99973184
51Urticaria (HP:0001025)2.94616322
52Gastrointestinal stroma tumor (HP:0100723)2.91863531
53IgG deficiency (HP:0004315)2.91705014
54Abnormality of eosinophils (HP:0001879)2.91568401
55Hypochromic microcytic anemia (HP:0004840)2.90193752
56Chronic diarrhea (HP:0002028)2.88589259
57Abnormality of T cell physiology (HP:0011840)2.87888341
58Chronic sinusitis (HP:0011109)2.83716513
59Pulmonary infiltrates (HP:0002113)2.81494915
60Spontaneous hematomas (HP:0007420)2.80378699
61Granulocytopenia (HP:0001913)2.74165258
62Recurrent gram-negative bacterial infections (HP:0005420)2.70315811
63Encephalitis (HP:0002383)2.69273373
64Bronchitis (HP:0012387)2.68446175
65Increased IgE level (HP:0003212)2.66215303
66Arterial thrombosis (HP:0004420)2.63763157
67Abnormality of macrophages (HP:0004311)2.62628006
68Hemoptysis (HP:0002105)2.61109283
69Thrombocytosis (HP:0001894)2.53343792
70Emphysema (HP:0002097)2.52611613
71Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.51603450
72IgA deficiency (HP:0002720)2.49820969
73Osteomyelitis (HP:0002754)2.44543158
74Keratoconjunctivitis sicca (HP:0001097)2.41312785
75Anorexia (HP:0002039)2.40172018
76Periodontitis (HP:0000704)2.39111932
77Episodic fever (HP:0001954)2.38675721
78Lymphoma (HP:0002665)2.38351923
79Gingivitis (HP:0000230)2.36497668
80Papilledema (HP:0001085)2.34119713
81Chest pain (HP:0100749)2.33078828
82Hematochezia (HP:0002573)2.30848610
83Gastrointestinal infarctions (HP:0005244)2.30057708
84Prolonged bleeding time (HP:0003010)2.30002104
85Viral hepatitis (HP:0006562)2.29200920
86Joint swelling (HP:0001386)2.26931015
87Microcytic anemia (HP:0001935)2.25273114
88Abnormality of the pleura (HP:0002103)2.23030668
89Interstitial pulmonary disease (HP:0006530)2.22703275
90Recurrent otitis media (HP:0000403)2.19959917
91Slow saccadic eye movements (HP:0000514)2.17568453
92Keratoconjunctivitis (HP:0001096)2.17133327
93Restrictive lung disease (HP:0002091)2.13291953
94Skin ulcer (HP:0200042)2.11014059
95Increased density of long bones (HP:0006392)2.10275094
96Sepsis (HP:0100806)2.09400790
97Recurrent pneumonia (HP:0006532)2.07625815
98Epistaxis (HP:0000421)2.06526452
99Gangrene (HP:0100758)2.06275945
100Autoimmune hemolytic anemia (HP:0001890)2.05057180
101Gingival bleeding (HP:0000225)2.01932105
102Hypergammaglobulinemia (HP:0010702)1.99467238
103Petechiae (HP:0000967)1.97386650
104Hypoplasia of the thymus (HP:0000778)1.95790638
105Recurrent lower respiratory tract infections (HP:0002783)1.95605875
106Peritonitis (HP:0002586)1.95092788
107Fatigue (HP:0012378)1.94026180
108Glomerulopathy (HP:0100820)1.93492433
109Increased IgM level (HP:0003496)1.93443722
110Abnormality of the peritoneum (HP:0002585)1.91837884
111Acute hepatic failure (HP:0006554)1.90999225
112Arthralgia (HP:0002829)1.87588389
113Leukopenia (HP:0001882)1.87051187
114Abnormal platelet volume (HP:0011876)1.85822443
115Cheilitis (HP:0100825)1.85038875
116Pulmonary embolism (HP:0002204)1.84675470
117Basal cell carcinoma (HP:0002671)1.83902953
118Keratitis (HP:0000491)1.81649252
119Abnormality of the endocardium (HP:0004306)1.80704306

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K15.72008792
2TXK3.72598240
3PRPF4B3.02571303
4TYK22.92772428
5MAP3K102.86785151
6JAK32.85378169
7STK102.68531093
8MAP3K142.60681130
9ITK2.34841621
10ZAP702.32121471
11GRK62.30682626
12JAK12.16839709
13IKBKE2.16670854
14BLK2.09725741
15TBK12.01428421
16IRAK42.01155962
17EEF2K1.84587162
18BTK1.84375287
19FGFR41.84273233
20MAP3K131.82416356
21SYK1.73904543
22CSF1R1.73571002
23CSK1.69110581
24SIK21.67503272
25RIPK41.63348598
26LCK1.62226508
27CDK121.62214448
28KIT1.58493900
29HCK1.56625386
30TEC1.53277529
31IRAK31.52921039
32IKBKB1.49648232
33FGFR31.49349566
34MARK31.48860807
35ERN11.33390313
36TGFBR21.32052710
37LRRK21.26512909
38CLK11.24163154
39FES1.23396628
40NLK1.22002978
41PIM11.21845859
42MAP3K31.21832262
43EPHB11.15721311
44RPS6KA41.13633055
45CHUK1.12199271
46SMG11.07209227
47MAP3K111.06676991
48LYN1.04329790
49SIK31.00370607
50MAP3K10.98811603
51TRIB30.91625086
52CDC42BPA0.90246541
53JAK20.88294492
54PKN20.87787464
55PRKCQ0.86752996
56TAOK30.84386617
57MST40.83197254
58PRKCH0.82008729
59MAP2K30.81714491
60EPHA30.81626653
61YES10.79904238
62KSR20.77433345
63FLT30.77323602
64STK40.72400195
65CAMKK10.72250844
66BMPR20.71676911
67CDK40.71029796
68PIK3CG0.70782520
69NEK20.70350671
70TTN0.70318124
71BRD40.69766738
72MAP3K70.66655051
73MELK0.64467359
74PTK60.63325681
75PDPK10.60676876
76CAMKK20.60648759
77PASK0.59166989
78TNK20.56766474
79STK110.56152667
80PTK2B0.53623005
81CDK90.52303849
82MATK0.51973549
83HIPK20.49844442
84TESK20.49401727
85PDK10.49046482
86CAMK1D0.48879621
87CAMK1G0.47814716
88CDK190.47190467
89SGK20.46435626
90ALK0.45675689
91TAOK20.45020047
92RET0.43779479
93STK380.41659973
94KDR0.41399965
95IRAK20.40560029
96IRAK10.39885406
97CDK60.39659081
98PDGFRB0.39484186
99MAPK70.38541397
100DYRK1B0.38240090
101MAP3K80.38023020
102SIK10.37586961
103MAPKAPK20.36810811
104MAPK120.35969770
105MAP2K20.35954195
106TRPM70.35464563
107MAP3K20.34967680
108MAPK40.34485890
109MAPK110.33335794
110EGFR0.33035833
111PRKD20.32695294
112MAP3K60.32302187
113SGK30.32263751
114FYN0.32065529
115ABL10.31288723
116CAMK40.30800813
117RPS6KA60.30171200
118INSR0.29717351
119MARK20.29000467
120ATR0.28491724
121TAOK10.27843023
122MAPK30.24143407
123FGR0.23129977
124RPS6KA50.19313378
125PRKCD0.18922300
126RPS6KC10.17938679
127RPS6KL10.17938679
128NEK90.17451029

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053404.28420199
2B cell receptor signaling pathway_Homo sapiens_hsa046622.89964057
3NF-kappa B signaling pathway_Homo sapiens_hsa040642.72575397
4T cell receptor signaling pathway_Homo sapiens_hsa046602.69588850
5Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.59531754
6Leishmaniasis_Homo sapiens_hsa051402.54205342
7Measles_Homo sapiens_hsa051622.50804488
8Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.48261903
9Osteoclast differentiation_Homo sapiens_hsa043802.44493989
10Intestinal immune network for IgA production_Homo sapiens_hsa046722.30774535
11Graft-versus-host disease_Homo sapiens_hsa053322.20460888
12Antigen processing and presentation_Homo sapiens_hsa046122.16896338
13Hematopoietic cell lineage_Homo sapiens_hsa046402.04443327
14Allograft rejection_Homo sapiens_hsa053302.03895784
15Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.87660803
16Jak-STAT signaling pathway_Homo sapiens_hsa046301.73894909
17Herpes simplex infection_Homo sapiens_hsa051681.70125281
18RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.68775933
19Toll-like receptor signaling pathway_Homo sapiens_hsa046201.67736574
20NOD-like receptor signaling pathway_Homo sapiens_hsa046211.66556369
21Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.59502027
22Toxoplasmosis_Homo sapiens_hsa051451.57077534
23Chemokine signaling pathway_Homo sapiens_hsa040621.53500503
24Viral myocarditis_Homo sapiens_hsa054161.49875903
25Influenza A_Homo sapiens_hsa051641.47965556
26Acute myeloid leukemia_Homo sapiens_hsa052211.46894487
27Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.43302127
28Hepatitis B_Homo sapiens_hsa051611.40739141
29TNF signaling pathway_Homo sapiens_hsa046681.38904379
30Leukocyte transendothelial migration_Homo sapiens_hsa046701.38758182
31Tuberculosis_Homo sapiens_hsa051521.35643414
32Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.32000734
33Chronic myeloid leukemia_Homo sapiens_hsa052201.30777437
34Shigellosis_Homo sapiens_hsa051311.29098826
35Apoptosis_Homo sapiens_hsa042101.28533335
36Staphylococcus aureus infection_Homo sapiens_hsa051501.27713266
37Legionellosis_Homo sapiens_hsa051341.21368089
38Malaria_Homo sapiens_hsa051441.20141698
39Pancreatic cancer_Homo sapiens_hsa052121.16795683
40Epstein-Barr virus infection_Homo sapiens_hsa051691.12693460
41Pertussis_Homo sapiens_hsa051331.12063117
42Autoimmune thyroid disease_Homo sapiens_hsa053201.12018339
43Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.04761202
44HTLV-I infection_Homo sapiens_hsa051661.02260268
45Platelet activation_Homo sapiens_hsa046111.02077957
46AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.99837502
47Transcriptional misregulation in cancer_Homo sapiens_hsa052020.96679206
48Neurotrophin signaling pathway_Homo sapiens_hsa047220.96507066
49Asthma_Homo sapiens_hsa053100.91924011
50Hepatitis C_Homo sapiens_hsa051600.91516121
51Type I diabetes mellitus_Homo sapiens_hsa049400.91445773
52Viral carcinogenesis_Homo sapiens_hsa052030.90248907
53Phagosome_Homo sapiens_hsa041450.88379954
54Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.88238261
55Non-homologous end-joining_Homo sapiens_hsa034500.87736722
56Non-small cell lung cancer_Homo sapiens_hsa052230.85821725
57Colorectal cancer_Homo sapiens_hsa052100.85562013
58Salmonella infection_Homo sapiens_hsa051320.85417619
59Prolactin signaling pathway_Homo sapiens_hsa049170.82986351
60Notch signaling pathway_Homo sapiens_hsa043300.80022421
61Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.79317381
62VEGF signaling pathway_Homo sapiens_hsa043700.78672532
63Small cell lung cancer_Homo sapiens_hsa052220.76983190
64Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.76697416
65Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.70529174
66Dorso-ventral axis formation_Homo sapiens_hsa043200.67803894
67Base excision repair_Homo sapiens_hsa034100.66436615
68Phosphatidylinositol signaling system_Homo sapiens_hsa040700.64159109
69African trypanosomiasis_Homo sapiens_hsa051430.63529996
70p53 signaling pathway_Homo sapiens_hsa041150.59777701
71Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.59270519
72Other glycan degradation_Homo sapiens_hsa005110.58043369
73GnRH signaling pathway_Homo sapiens_hsa049120.57872259
74FoxO signaling pathway_Homo sapiens_hsa040680.56904348
75Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.56701091
76Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.56633749
77Rheumatoid arthritis_Homo sapiens_hsa053230.54796836
78mTOR signaling pathway_Homo sapiens_hsa041500.53894670
79Insulin resistance_Homo sapiens_hsa049310.52491566
80Regulation of actin cytoskeleton_Homo sapiens_hsa048100.52164341
81Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.51849938
82MicroRNAs in cancer_Homo sapiens_hsa052060.51357321
83Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.50991626
84MAPK signaling pathway_Homo sapiens_hsa040100.50632639
85Glycerophospholipid metabolism_Homo sapiens_hsa005640.49392246
86Endocytosis_Homo sapiens_hsa041440.48738225
87Inositol phosphate metabolism_Homo sapiens_hsa005620.47773206
88Renal cell carcinoma_Homo sapiens_hsa052110.47485030
89ErbB signaling pathway_Homo sapiens_hsa040120.44843620
90DNA replication_Homo sapiens_hsa030300.44456148
91HIF-1 signaling pathway_Homo sapiens_hsa040660.43981730
92Prostate cancer_Homo sapiens_hsa052150.43372053
93Spliceosome_Homo sapiens_hsa030400.42271437
94Thyroid hormone signaling pathway_Homo sapiens_hsa049190.41567605
95Carbohydrate digestion and absorption_Homo sapiens_hsa049730.41064418
96Sphingolipid signaling pathway_Homo sapiens_hsa040710.40072595
97SNARE interactions in vesicular transport_Homo sapiens_hsa041300.39745114
98Regulation of autophagy_Homo sapiens_hsa041400.38074120
99Glycosaminoglycan degradation_Homo sapiens_hsa005310.37496838
100Adipocytokine signaling pathway_Homo sapiens_hsa049200.37406716
101Lysine degradation_Homo sapiens_hsa003100.37125638
102Glioma_Homo sapiens_hsa052140.36769129
103Endometrial cancer_Homo sapiens_hsa052130.36307390
104Long-term potentiation_Homo sapiens_hsa047200.35940592
105Ras signaling pathway_Homo sapiens_hsa040140.35144421
106Estrogen signaling pathway_Homo sapiens_hsa049150.34041870
107Pathways in cancer_Homo sapiens_hsa052000.33931867
108Longevity regulating pathway - mammal_Homo sapiens_hsa042110.31767052
109Proteoglycans in cancer_Homo sapiens_hsa052050.31430541
110Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.30936713
111Lysosome_Homo sapiens_hsa041420.30482509
112Rap1 signaling pathway_Homo sapiens_hsa040150.30300443
113Phospholipase D signaling pathway_Homo sapiens_hsa040720.29635008
114Type II diabetes mellitus_Homo sapiens_hsa049300.29577711
115Choline metabolism in cancer_Homo sapiens_hsa052310.26918070
116mRNA surveillance pathway_Homo sapiens_hsa030150.26798111
117Mismatch repair_Homo sapiens_hsa034300.24791340

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