AKIRIN2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neutrophil activation involved in immune response (GO:0002283)5.96094226
2piRNA metabolic process (GO:0034587)5.72478262
3regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.68827168
4response to peptidoglycan (GO:0032494)4.61787425
5positive regulation by symbiont of host defense response (GO:0052509)4.57181557
6modulation by symbiont of host defense response (GO:0052031)4.57181557
7modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.57181557
8modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.57181557
9positive regulation by organism of defense response of other organism involved in symbiotic interact4.57181557
10modulation by symbiont of host immune response (GO:0052553)4.57181557
11positive regulation of mast cell activation (GO:0033005)4.42559260
12mitotic sister chromatid cohesion (GO:0007064)4.33915457
13negative regulation of erythrocyte differentiation (GO:0045647)4.31448181
14mitotic metaphase plate congression (GO:0007080)4.25442463
15regulation of mast cell degranulation (GO:0043304)4.25293421
16histone H2A monoubiquitination (GO:0035518)4.23241887
17mitotic chromosome condensation (GO:0007076)4.14834021
18regulation of sister chromatid cohesion (GO:0007063)4.12985811
19positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.12767483
20neutrophil activation (GO:0042119)4.05299107
21positive regulation of gamma-delta T cell activation (GO:0046645)4.05048724
22cellular extravasation (GO:0045123)4.04262144
23protein K6-linked ubiquitination (GO:0085020)4.03380960
24immunoglobulin mediated immune response (GO:0016064)3.93296209
25positive regulation of mast cell degranulation (GO:0043306)3.91529251
26positive regulation of mast cell activation involved in immune response (GO:0033008)3.91529251
27regulation of mast cell activation involved in immune response (GO:0033006)3.89454074
28male meiosis (GO:0007140)3.89006879
29granulocyte activation (GO:0036230)3.88738907
30leukocyte migration involved in inflammatory response (GO:0002523)3.80630054
31detection of other organism (GO:0098543)3.73776884
32regulation of T-helper 2 cell differentiation (GO:0045628)3.73363367
33germinal center formation (GO:0002467)3.71062010
34regulation of exit from mitosis (GO:0007096)3.59877532
35histone H2A ubiquitination (GO:0033522)3.57009184
36regulation of mast cell activation (GO:0033003)3.56981116
37synaptonemal complex assembly (GO:0007130)3.56425694
38monoubiquitinated protein deubiquitination (GO:0035520)3.55434245
39gene silencing by RNA (GO:0031047)3.52907416
40response to muramyl dipeptide (GO:0032495)3.52882870
41metaphase plate congression (GO:0051310)3.52799581
42female gamete generation (GO:0007292)3.52553458
43detection of bacterium (GO:0016045)3.50268623
44regulation of meiosis (GO:0040020)3.47629848
45synaptonemal complex organization (GO:0070193)3.46717251
46microtubule severing (GO:0051013)3.46559855
47negative regulation of interleukin-12 production (GO:0032695)3.45440901
48meiotic cell cycle (GO:0051321)3.44522280
49negative regulation of histone methylation (GO:0031061)3.43200966
50macrophage activation involved in immune response (GO:0002281)3.40511040
51protein localization to chromosome (GO:0034502)3.40128616
52regulation of leukocyte degranulation (GO:0043300)3.40036869
53regulation of meiosis I (GO:0060631)3.36467010
54regulation of myeloid leukocyte mediated immunity (GO:0002886)3.36345423
553-UTR-mediated mRNA stabilization (GO:0070935)3.31582558
56negative regulation of cell killing (GO:0031342)3.31502614
57negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.31502614
58protein localization to chromosome, centromeric region (GO:0071459)3.30294861
59positive regulation of chromosome segregation (GO:0051984)3.29094189
60response to host immune response (GO:0052572)3.26507196
61response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.26507196
62attachment of spindle microtubules to kinetochore (GO:0008608)3.24977225
63response to host (GO:0075136)3.23758150
64response to host defenses (GO:0052200)3.23758150
65response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.23758150
66regulation of early endosome to late endosome transport (GO:2000641)3.23749591
67establishment of chromosome localization (GO:0051303)3.23162580
68DNA methylation involved in gamete generation (GO:0043046)3.22158027
69regulation of spindle organization (GO:0090224)3.19008357
70kinetochore organization (GO:0051383)3.18119206
71mitotic sister chromatid segregation (GO:0000070)3.17358492
72kinetochore assembly (GO:0051382)3.16405420
73B cell mediated immunity (GO:0019724)3.15226261
74DNA damage response, signal transduction resulting in transcription (GO:0042772)3.14270730
75pre-miRNA processing (GO:0031054)3.13052265
76regulation of chromosome segregation (GO:0051983)3.08999858
77positive regulation of type 2 immune response (GO:0002830)3.08490391
78DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.08348528
79myeloid cell activation involved in immune response (GO:0002275)3.06020196
80regulation of transforming growth factor beta2 production (GO:0032909)3.05998066
81microtubule depolymerization (GO:0007019)3.04912562
82positive regulation of B cell differentiation (GO:0045579)3.04072168
83sister chromatid segregation (GO:0000819)3.03107339
84positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.00931858
85positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.00931858
86positive regulation of mitotic sister chromatid separation (GO:1901970)3.00931858
87regulation of telomere maintenance via telomerase (GO:0032210)2.97977848
88DNA damage induced protein phosphorylation (GO:0006975)2.95891988
89positive regulation of leukocyte degranulation (GO:0043302)2.94478095
90detection of external biotic stimulus (GO:0098581)2.92337249
91regulation of regulated secretory pathway (GO:1903305)2.91661390
92spindle checkpoint (GO:0031577)2.88233897
93regulation of female gonad development (GO:2000194)2.88160056
94neutrophil mediated immunity (GO:0002446)2.87502666
95regulation of B cell receptor signaling pathway (GO:0050855)2.87382430
96lipopolysaccharide-mediated signaling pathway (GO:0031663)2.86850266
97positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.86787583
98regulation of RNA export from nucleus (GO:0046831)2.86245839
99notochord development (GO:0030903)2.86003004
100cellular response to arsenic-containing substance (GO:0071243)2.85707089
101B cell homeostasis (GO:0001782)2.85593325
102chromosome segregation (GO:0007059)2.85146837
103negative regulation of meiosis (GO:0045835)2.85013549
104microglial cell activation (GO:0001774)2.84766898
105detection of molecule of bacterial origin (GO:0032490)2.84447603
106protein localization to kinetochore (GO:0034501)2.84439148
107negative regulation of homotypic cell-cell adhesion (GO:0034111)2.84018841
108antigen processing and presentation of endogenous antigen (GO:0019883)2.83520495
109B cell receptor signaling pathway (GO:0050853)2.83248829
110SMAD protein complex assembly (GO:0007183)2.82274648
111regulation of interferon-beta biosynthetic process (GO:0045357)2.81698237
112DNA replication-dependent nucleosome assembly (GO:0006335)2.80975614
113DNA replication-dependent nucleosome organization (GO:0034723)2.80975614
114respiratory burst (GO:0045730)2.79427531
115negative regulation of retinoic acid receptor signaling pathway (GO:0048387)2.79054435
116poly(A)+ mRNA export from nucleus (GO:0016973)2.78012776
117regulation of DNA methylation (GO:0044030)2.77174933
118membrane disassembly (GO:0030397)2.76721339
119nuclear envelope disassembly (GO:0051081)2.76721339
120regulation of platelet aggregation (GO:0090330)2.75637605
121oocyte maturation (GO:0001556)2.75358217
122multicellular organism reproduction (GO:0032504)2.74707927
123negative regulation of smooth muscle cell differentiation (GO:0051151)2.74596484
124negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.74511492
125mitotic nuclear envelope disassembly (GO:0007077)2.73337435
126antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.72670707
127cytoplasmic mRNA processing body assembly (GO:0033962)2.71832196
128adenosine receptor signaling pathway (GO:0001973)2.71018510
129detection of biotic stimulus (GO:0009595)2.70549430
130regulation of mitotic spindle organization (GO:0060236)2.70069454
131sister chromatid cohesion (GO:0007062)2.69402936
132meiotic chromosome segregation (GO:0045132)2.69233023
133histone exchange (GO:0043486)2.69007875
134fusion of sperm to egg plasma membrane (GO:0007342)2.68829912
135leukocyte aggregation (GO:0070486)2.68374217
136mitotic spindle checkpoint (GO:0071174)2.67884430
137regulation of meiotic cell cycle (GO:0051445)2.66582832
138regulation of NFAT protein import into nucleus (GO:0051532)2.66566051
139regulation of histone H3-K27 methylation (GO:0061085)2.65600028
140positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.65523435
141defense response to protozoan (GO:0042832)2.64889629
142negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.64856273
143regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.64496827
144regulation of chromatin binding (GO:0035561)2.64437686
145positive regulation of toll-like receptor signaling pathway (GO:0034123)2.61359363
146regulation of MHC class II biosynthetic process (GO:0045346)2.61263886
147regulation of centriole replication (GO:0046599)2.60941172
148negative regulation of chromosome segregation (GO:0051985)2.58985461
149regulation of platelet activation (GO:0010543)2.58918044
150positive regulation of regulated secretory pathway (GO:1903307)2.58404854
151leukocyte degranulation (GO:0043299)2.58379513
152macrophage activation (GO:0042116)2.57862943
153positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.56589613
154nuclear envelope organization (GO:0006998)2.55382516
155DNA replication-independent nucleosome assembly (GO:0006336)2.53878504
156DNA replication-independent nucleosome organization (GO:0034724)2.53878504
157negative regulation of inclusion body assembly (GO:0090084)2.53504816
158chromosome condensation (GO:0030261)2.53409171
159negative regulation of interleukin-17 production (GO:0032700)2.52006593
160regulation of mitotic metaphase/anaphase transition (GO:0030071)2.51778219
161positive regulation of isotype switching (GO:0045830)2.50566012
162positive regulation of immunoglobulin mediated immune response (GO:0002891)2.50531829
163positive regulation of B cell mediated immunity (GO:0002714)2.50531829
164protein K11-linked ubiquitination (GO:0070979)2.50423930
165myeloid dendritic cell differentiation (GO:0043011)2.49752974
166regulation of T-helper 1 cell differentiation (GO:0045625)2.49709095
167interferon-gamma-mediated signaling pathway (GO:0060333)2.49314939
168negative regulation of DNA-templated transcription, elongation (GO:0032785)2.49234536
169negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.49234536
170antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.48937944
171negative regulation of T cell mediated immunity (GO:0002710)2.48389215
172negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.48294434
173negative regulation of sister chromatid segregation (GO:0033046)2.48294434
174negative regulation of mitotic sister chromatid separation (GO:2000816)2.48294434
175negative regulation of mitotic sister chromatid segregation (GO:0033048)2.48294434
176chromatin assembly or disassembly (GO:0006333)2.48179617
177DNA alkylation (GO:0006305)2.48073135
178DNA methylation (GO:0006306)2.48073135
179gene silencing (GO:0016458)2.47289718
180protein K48-linked ubiquitination (GO:0070936)2.47162422
181negative regulation of cell aging (GO:0090344)2.47074906
182regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.46583177
183regulation of gamma-delta T cell activation (GO:0046643)2.46289815
184regulation of clathrin-mediated endocytosis (GO:2000369)2.45830584
185Arp2/3 complex-mediated actin nucleation (GO:0034314)2.45340671
186regulation of type 2 immune response (GO:0002828)2.45332354
187meiotic nuclear division (GO:0007126)2.45089031
188mitotic spindle assembly checkpoint (GO:0007094)2.43945564
189cytoskeleton-dependent cytokinesis (GO:0061640)2.43738162
190response to protozoan (GO:0001562)2.43661492
191microtubule polymerization or depolymerization (GO:0031109)2.42902347
192layer formation in cerebral cortex (GO:0021819)2.42869231
193myeloid dendritic cell activation (GO:0001773)2.42372784
194lipoxygenase pathway (GO:0019372)2.42211582
195T-helper 1 type immune response (GO:0042088)2.41680415
196regulation of dendritic cell antigen processing and presentation (GO:0002604)2.41174478
197regulation of germinal center formation (GO:0002634)2.40132201
198negative regulation of lymphocyte mediated immunity (GO:0002707)2.39836246

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human6.38070729
2MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse4.03727603
3BP1_19119308_ChIP-ChIP_Hs578T_Human3.81648408
4MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.68719035
5SALL1_21062744_ChIP-ChIP_HESCs_Human3.45399036
6IRF8_21731497_ChIP-ChIP_J774_Mouse3.44084741
7SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.12059271
8* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.08927737
9VDR_21846776_ChIP-Seq_THP-1_Human3.00886646
10IRF8_22096565_ChIP-ChIP_GC-B_Human2.79844289
11NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.79776750
12MYB_21317192_ChIP-Seq_ERMYB_Mouse2.78225690
13TCF3_18467660_ChIP-ChIP_MESCs_Mouse2.67293571
14SALL4_18804426_ChIP-ChIP_MESCs_Mouse2.65967420
15VDR_24763502_ChIP-Seq_THP-1_Human2.62099914
16SCL_19346495_ChIP-Seq_HPC-7_Human2.61185267
17FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.60658950
18IRF8_27001747_Chip-Seq_BMDM_Mouse2.55511179
19VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.43688165
20E2F7_22180533_ChIP-Seq_HELA_Human2.42073515
21STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.35271842
22SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.34854811
23RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.33506656
24IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.30194240
25E2F4_17652178_ChIP-ChIP_JURKAT_Human2.27781677
26RUNX1_22412390_ChIP-Seq_EML_Mouse2.26761746
27STAT6_21828071_ChIP-Seq_BEAS2B_Human2.26719936
28* SPI1_23547873_ChIP-Seq_NB4_Human2.20952889
29* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse2.17839438
30NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.17818147
31TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse2.17679634
32STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.14760742
33UTX_26944678_Chip-Seq_JUKART_Human2.13433649
34RBPJ_22232070_ChIP-Seq_NCS_Mouse2.12056703
35SPI1_23127762_ChIP-Seq_K562_Human2.09564067
36GATA1_26923725_Chip-Seq_HPCs_Mouse2.08842398
37KDM2B_26808549_Chip-Seq_SUP-B15_Human2.05660455
38E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.05283389
39ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.04154976
40KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.01960311
41HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.01477378
42* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.00930907
43MAF_26560356_Chip-Seq_TH1_Human1.95705219
44* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.95619044
45Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.93636908
46NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.90514860
47* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.88468503
48* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.87910999
49STAT4_19710469_ChIP-ChIP_TH1__Mouse1.86930102
50FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.84877347
51ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.84736379
52MYB_26560356_Chip-Seq_TH2_Human1.82441690
53MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.77829719
54ELK3_25401928_ChIP-Seq_HUVEC_Human1.74323660
55LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.73511999
56STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.64813194
57NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.63685877
58GATA1_22383799_ChIP-Seq_G1ME_Mouse1.63324155
59RNF2_27304074_Chip-Seq_NSC_Mouse1.62721432
60AR_21909140_ChIP-Seq_LNCAP_Human1.61314739
61NANOG_21062744_ChIP-ChIP_HESCs_Human1.56994371
62VDR_24787735_ChIP-Seq_THP-1_Human1.55321805
63LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.55209083
64ZNF263_19887448_ChIP-Seq_K562_Human1.53684116
65TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.53682330
66GATA1_19941827_ChIP-Seq_MEL_Mouse1.53370672
67THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.52895407
68TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.52680282
69PKCTHETA_26484144_Chip-Seq_BREAST_Human1.52337455
70MYB_26560356_Chip-Seq_TH1_Human1.50358393
71FUS_26573619_Chip-Seq_HEK293_Human1.49958990
72NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.48894368
73SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.47966193
74RUNX_20019798_ChIP-Seq_JUKART_Human1.47881909
75SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.47840493
76TP63_19390658_ChIP-ChIP_HaCaT_Human1.47239829
77MAF_26560356_Chip-Seq_TH2_Human1.46572253
78EZH2_22144423_ChIP-Seq_EOC_Human1.44031928
79NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.42755122
80FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.41528495
81NCOR1_26117541_ChIP-Seq_K562_Human1.39971203
82CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.39964221
83PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.39663747
84MYCN_18555785_ChIP-Seq_MESCs_Mouse1.38776270
85GATA2_22383799_ChIP-Seq_G1ME_Mouse1.38036502
86FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.37157418
87CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.33269737
88GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.29109371
89GATA1_19941826_ChIP-Seq_K562_Human1.29045094
90SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.28689478
91KLF4_18555785_ChIP-Seq_MESCs_Mouse1.28255112
92TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.28030552
93TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.27418779
94E2F1_21310950_ChIP-Seq_MCF-7_Human1.27418063
95SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.27390516
96PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.26846044
97PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.26193554
98STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.23849443
99PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.21217372
100SMAD_19615063_ChIP-ChIP_OVARY_Human1.20721275
101PU.1_20513432_ChIP-Seq_Bcells_Mouse1.20416840
102ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.19493573
103CIITA_25753668_ChIP-Seq_RAJI_Human1.18551740
104CTCF_27219007_Chip-Seq_ERYTHROID_Human1.17820336
105WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.17469025
106ZFP281_27345836_Chip-Seq_ESCs_Mouse1.17026868
107IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.16519602
108ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.16446782
109DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.15396738
110* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.15051928
111MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.14963399
112TCF3_18692474_ChIP-Seq_MESCs_Mouse1.14569259
113CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.12979689
114IGF1R_20145208_ChIP-Seq_DFB_Human1.12537699
115LXR_22292898_ChIP-Seq_THP-1_Human1.11465241
116CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.11221524
117TFEB_21752829_ChIP-Seq_HELA_Human1.10234368
118EWS_26573619_Chip-Seq_HEK293_Human1.10172953
119ZNF274_21170338_ChIP-Seq_K562_Hela1.09250578
120KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.08922075
121KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.08922075
122KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.08922075
123KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.08905218
124NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.08897802
125PU_27001747_Chip-Seq_BMDM_Mouse1.08551288
126EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.08134872
127POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.07900612
128TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07900612
129CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.07847975
130CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.07186074
131KDM2B_26808549_Chip-Seq_JURKAT_Human1.07000868
132NOTCH1_21737748_ChIP-Seq_TLL_Human1.03199735
133* GATA3_27048872_Chip-Seq_THYMUS_Human1.02346603
134POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.02216308
135* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02122837
136IKZF1_21737484_ChIP-ChIP_HCT116_Human1.01895204
137SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.99619440
138MYC_18940864_ChIP-ChIP_HL60_Human0.99587367
139TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.98644119
140KDM2B_26808549_Chip-Seq_DND41_Human0.98459856
141GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.98038641
142KDM2B_26808549_Chip-Seq_K562_Human0.97912746
143RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.97252628
144CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.96969380
145EGR1_19374776_ChIP-ChIP_THP-1_Human0.95750326
146PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.95249402
147CBX2_27304074_Chip-Seq_ESCs_Mouse0.95005624
148CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94922843
149RING1B_27294783_Chip-Seq_NPCs_Mouse0.94367497
150GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.94345279
151BCL6_27268052_Chip-Seq_Bcells_Human0.93751686
152SRY_22984422_ChIP-ChIP_TESTIS_Rat0.93560726
153TCF3_18692474_ChIP-Seq_MEFs_Mouse0.92379954
154FLI1_27457419_Chip-Seq_LIVER_Mouse0.92364444
155DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.92291424
156* PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.90397157
157ISL1_27105846_Chip-Seq_CPCs_Mouse0.90279581
158SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.89631231
159MYC_22102868_ChIP-Seq_BL_Human0.87013688
160CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.86729598
161FOXM1_26456572_ChIP-Seq_MCF-7_Human0.86179300
162NANOG_18692474_ChIP-Seq_MESCs_Mouse0.85914685
163MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.85651274
164CTBP2_25329375_ChIP-Seq_LNCAP_Human0.85374868
165RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.83930761
166SOX2_16153702_ChIP-ChIP_HESCs_Human0.83877981
167KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.83097638
168SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.82893170
169RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.82032007
170TCF7_22412390_ChIP-Seq_EML_Mouse0.81691028
171TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.81244590
172LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.80863214
173ZFP281_18757296_ChIP-ChIP_E14_Mouse0.80551609
174AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.80542560
175SMAD3_21741376_ChIP-Seq_ESCs_Human0.80526668
176KAP1_22055183_ChIP-Seq_ESCs_Mouse0.80525836
177MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.79167364
178CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.78811246
179MYC_18555785_ChIP-Seq_MESCs_Mouse0.78304730
180TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.77661179
181TCF4_18268006_ChIP-ChIP_LS174T_Human0.77260236
182E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.77004355
183CHD1_26751641_Chip-Seq_LNCaP_Human0.75480645
184ZFX_18555785_ChIP-Seq_MESCs_Mouse0.75358519

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation4.57000179
2MP0003724_increased_susceptibility_to3.99922009
3MP0005464_abnormal_platelet_physiology3.91142730
4MP0003436_decreased_susceptibility_to3.69592662
5MP0001835_abnormal_antigen_presentation3.35107619
6MP0002653_abnormal_ependyma_morphology3.12952048
7MP0009278_abnormal_bone_marrow3.02761733
8MP0008877_abnormal_DNA_methylation2.62063355
9MP0000465_gastrointestinal_hemorrhage2.61316894
10MP0005000_abnormal_immune_tolerance2.61235522
11MP0003693_abnormal_embryo_hatching2.59714170
12MP0008260_abnormal_autophagy2.59119865
13MP0002419_abnormal_innate_immunity2.54137746
14MP0004957_abnormal_blastocyst_morpholog2.51524148
15MP0002102_abnormal_ear_morphology2.49775608
16MP0003828_pulmonary_edema2.42737145
17MP0003718_maternal_effect2.37032920
18MP0001800_abnormal_humoral_immune2.35572208
19MP0003646_muscle_fatigue2.34856665
20MP0003880_abnormal_central_pattern2.30863772
21MP0003111_abnormal_nucleus_morphology2.29470788
22MP0002148_abnormal_hypersensitivity_rea2.25688148
23MP0002452_abnormal_antigen_presenting2.24368627
24MP0003077_abnormal_cell_cycle2.24184624
25MP0002723_abnormal_immune_serum2.22327311
26MP0005671_abnormal_response_to2.22063395
27MP0001545_abnormal_hematopoietic_system2.19823186
28MP0005397_hematopoietic_system_phenotyp2.19823186
29MP0005058_abnormal_lysosome_morphology2.18222234
30MP0005025_abnormal_response_to2.16986324
31MP0002420_abnormal_adaptive_immunity2.10804100
32MP0003315_abnormal_perineum_morphology2.07943304
33MP0010094_abnormal_chromosome_stability2.07300071
34MP0001790_abnormal_immune_system2.06396130
35MP0005387_immune_system_phenotype2.06396130
36MP0001819_abnormal_immune_cell2.05866426
37MP0000685_abnormal_immune_system2.04292935
38MP0001929_abnormal_gametogenesis2.03149825
39MP0003937_abnormal_limbs/digits/tail_de1.99405452
40MP0004510_myositis1.98423886
41MP0009785_altered_susceptibility_to1.95028064
42MP0002398_abnormal_bone_marrow1.94424490
43MP0003123_paternal_imprinting1.94073164
44MP0008004_abnormal_stomach_pH1.89471107
45MP0004185_abnormal_adipocyte_glucose1.83664352
46MP0003121_genomic_imprinting1.82868199
47MP0002210_abnormal_sex_determination1.82463900
48MP0002084_abnormal_developmental_patter1.82256689
49MP0005187_abnormal_penis_morphology1.81805848
50MP0003890_abnormal_embryonic-extraembry1.80809208
51MP0003300_gastrointestinal_ulcer1.80717272
52MP0002085_abnormal_embryonic_tissue1.78610275
53MP0010234_abnormal_vibrissa_follicle1.74345635
54MP0001730_embryonic_growth_arrest1.71072495
55MP0000716_abnormal_immune_system1.69333350
56MP0005410_abnormal_fertilization1.67505838
57MP0008932_abnormal_embryonic_tissue1.66380090
58MP0001533_abnormal_skeleton_physiology1.61154589
59MP0001697_abnormal_embryo_size1.56134291
60MP0002249_abnormal_larynx_morphology1.55532635
61MP0000653_abnormal_sex_gland1.55069176
62MP0000537_abnormal_urethra_morphology1.54848515
63MP0003861_abnormal_nervous_system1.54194248
64MP0000350_abnormal_cell_proliferation1.53913072
65MP0003656_abnormal_erythrocyte_physiolo1.51705780
66MP0000343_altered_response_to1.51410335
67MP0005451_abnormal_body_composition1.49507122
68MP0004859_abnormal_synaptic_plasticity1.48969857
69MP0003119_abnormal_digestive_system1.48580272
70MP0008057_abnormal_DNA_replication1.48253071
71MP0000858_altered_metastatic_potential1.47621223
72MP0000689_abnormal_spleen_morphology1.47434360
73MP0002282_abnormal_trachea_morphology1.45340578
74MP0000733_abnormal_muscle_development1.45054990
75MP0002722_abnormal_immune_system1.45011937
76MP0003698_abnormal_male_reproductive1.43886801
77MP0001145_abnormal_male_reproductive1.43724388
78MP0009333_abnormal_splenocyte_physiolog1.43608023
79MP0000778_abnormal_nervous_system1.43313075
80MP0002429_abnormal_blood_cell1.42645995
81MP0005623_abnormal_meninges_morphology1.42101988
82MP0004947_skin_inflammation1.38534094
83MP0003755_abnormal_palate_morphology1.38516151
84MP0003191_abnormal_cellular_cholesterol1.35667496
85MP0010030_abnormal_orbit_morphology1.33656187
86MP0009250_abnormal_appendicular_skeleto1.33640086
87MP0009840_abnormal_foam_cell1.33301513
88MP0004270_analgesia1.33072219
89MP0003938_abnormal_ear_development1.33011085
90MP0003075_altered_response_to1.32132315
91MP0006082_CNS_inflammation1.32071207
92MP0003172_abnormal_lysosome_physiology1.31427085
93MP0002161_abnormal_fertility/fecundity1.31133124
94MP0005380_embryogenesis_phenotype1.30978530
95MP0001672_abnormal_embryogenesis/_devel1.30978530
96MP0002132_abnormal_respiratory_system1.29297002
97MP0009764_decreased_sensitivity_to1.28860130
98MP0000703_abnormal_thymus_morphology1.24575752
99MP0005499_abnormal_olfactory_system1.23045984
100MP0005394_taste/olfaction_phenotype1.23045984
101MP0002998_abnormal_bone_remodeling1.22168297
102MP0003699_abnormal_female_reproductive1.21568232
103MP0003787_abnormal_imprinting1.21398316
104MP0003385_abnormal_body_wall1.21173029
105MP0001845_abnormal_inflammatory_respons1.18507590
106MP0006292_abnormal_olfactory_placode1.17306692
107MP0003183_abnormal_peptide_metabolism1.14812754
108MP0010155_abnormal_intestine_physiology1.14595290
109MP0003935_abnormal_craniofacial_develop1.13653669
110MP0002405_respiratory_system_inflammati1.13476803
111MP0001853_heart_inflammation1.12303016
112MP0001119_abnormal_female_reproductive1.12086899
113MP0003567_abnormal_fetal_cardiomyocyte1.11789059
114MP0005076_abnormal_cell_differentiation1.10279421
115MP0002086_abnormal_extraembryonic_tissu1.07763483
116MP0008007_abnormal_cellular_replicative1.04798612
117MP0009053_abnormal_anal_canal1.03498856
118MP0004145_abnormal_muscle_electrophysio1.03253679
119MP0000432_abnormal_head_morphology1.01622050
120MP0003984_embryonic_growth_retardation1.01335749
121MP0003942_abnormal_urinary_system1.01015546
122MP0005248_abnormal_Harderian_gland1.00825521
123MP0001851_eye_inflammation1.00249584
124MP0002088_abnormal_embryonic_growth/wei1.00098998
125MP0002116_abnormal_craniofacial_bone0.99685976
126* MP0002080_prenatal_lethality0.99647060
127MP0003763_abnormal_thymus_physiology0.98652585
128MP0002152_abnormal_brain_morphology0.98283652
129MP0004885_abnormal_endolymph0.97331555
130MP0008874_decreased_physiological_sensi0.97273672
131MP0000534_abnormal_ureter_morphology0.97201657
132MP0008789_abnormal_olfactory_epithelium0.96680643
133MP0008058_abnormal_DNA_repair0.94620291
134MP0000955_abnormal_spinal_cord0.93947974
135MP0004883_abnormal_blood_vessel0.92781509
136MP0002932_abnormal_joint_morphology0.91855316
137MP0000579_abnormal_nail_morphology0.91332585
138MP0001849_ear_inflammation0.90925199
139MP0002332_abnormal_exercise_endurance0.90658574
140MP0010678_abnormal_skin_adnexa0.89428180
141MP0005166_decreased_susceptibility_to0.89100837
142MP0001529_abnormal_vocalization0.87895864
143MP0005647_abnormal_sex_gland0.87388039
144MP0000428_abnormal_craniofacial_morphol0.87285258
145MP0003448_altered_tumor_morphology0.86732525
146MP0002177_abnormal_outer_ear0.86503046
147MP0004197_abnormal_fetal_growth/weight/0.86338164
148MP0008469_abnormal_protein_level0.85501111
149MP0000462_abnormal_digestive_system0.85040200
150MP0001299_abnormal_eye_distance/0.84784831
151MP0001915_intracranial_hemorrhage0.84463025
152MP0009763_increased_sensitivity_to0.83904505
153MP0003091_abnormal_cell_migration0.83412422
154MP0000049_abnormal_middle_ear0.82898909
155MP0000750_abnormal_muscle_regeneration0.82813454
156MP0009765_abnormal_xenobiotic_induced0.82178696
157MP0005167_abnormal_blood-brain_barrier0.82158775
158MP0002184_abnormal_innervation0.81542027
159MP0005395_other_phenotype0.81511155
160MP0002114_abnormal_axial_skeleton0.81276549
161MP0001340_abnormal_eyelid_morphology0.80567779
162MP0002233_abnormal_nose_morphology0.80476005
163MP0001293_anophthalmia0.79373275
164MP0001286_abnormal_eye_development0.78977066
165MP0003221_abnormal_cardiomyocyte_apopto0.78833503
166MP0005310_abnormal_salivary_gland0.78349734
167MP0004808_abnormal_hematopoietic_stem0.77728795
168MP0000490_abnormal_crypts_of0.77653031
169MP0002081_perinatal_lethality0.76520529
170MP0003453_abnormal_keratinocyte_physiol0.74274738
171MP0003941_abnormal_skin_development0.73209476
172MP0005390_skeleton_phenotype0.71691801
173MP0000569_abnormal_digit_pigmentation0.71390552
174MP0004233_abnormal_muscle_weight0.71373694
175MP0000751_myopathy0.70088201
176MP0000249_abnormal_blood_vessel0.68438384
177MP0000313_abnormal_cell_death0.67795214
178MP0005666_abnormal_adipose_tissue0.66098580
179MP0002277_abnormal_respiratory_mucosa0.64533200
180MP0005621_abnormal_cell_physiology0.61081395
181MP0000681_abnormal_thyroid_gland0.57773784
182MP0000759_abnormal_skeletal_muscle0.57615336
183MP0008961_abnormal_basal_metabolism0.55028529
184MP0002009_preneoplasia0.54277693
185MP0003795_abnormal_bone_structure0.53085044
186MP0005535_abnormal_body_temperature0.51814514
187MP0003866_abnormal_defecation0.51672480
188MP0001986_abnormal_taste_sensitivity0.50999914
189MP0002019_abnormal_tumor_incidence0.49545855
190MP0002127_abnormal_cardiovascular_syste0.47553559

Predicted human phenotypes

RankGene SetZ-score
1Prolonged bleeding time (HP:0003010)5.47708045
2Petechiae (HP:0000967)4.99457702
3Recurrent bacterial skin infections (HP:0005406)4.78945116
4Abnormality of macrophages (HP:0004311)4.74906516
5Male infertility (HP:0003251)4.70159678
6Purpura (HP:0000979)4.47173077
7Recurrent abscess formation (HP:0002722)4.38663260
8Eczematoid dermatitis (HP:0000976)4.06627888
9Abnormal platelet volume (HP:0011876)3.91357347
10Epistaxis (HP:0000421)3.88111812
11Stomatitis (HP:0010280)3.76452227
12Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.76255099
13Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.62744115
14Menorrhagia (HP:0000132)3.52562481
15Increased mean platelet volume (HP:0011877)3.50113728
16Myositis (HP:0100614)3.44313608
17Exercise-induced myalgia (HP:0003738)3.28937385
18Spontaneous hematomas (HP:0007420)3.26511168
19Gingival bleeding (HP:0000225)3.25129839
20Obstructive lung disease (HP:0006536)3.23950871
21Chronic obstructive pulmonary disease (HP:0006510)3.23950871
22Facial hemangioma (HP:0000329)3.22059311
23Papillary thyroid carcinoma (HP:0002895)3.10429927
24Retrobulbar optic neuritis (HP:0100654)3.04809985
25Optic neuritis (HP:0100653)3.04809985
26Mediastinal lymphadenopathy (HP:0100721)3.00643262
27Orchitis (HP:0100796)2.97512241
28Urticaria (HP:0001025)2.95516427
29Abnormality of the labia minora (HP:0012880)2.93737578
30Elevated erythrocyte sedimentation rate (HP:0003565)2.93170123
31Meningitis (HP:0001287)2.91519463
32Recurrent gram-negative bacterial infections (HP:0005420)2.88281492
33Oligodactyly (HP:0012165)2.85794371
34Patellar aplasia (HP:0006443)2.84462414
35Increased serum ferritin (HP:0003281)2.81032181
36Peripheral hypomyelination (HP:0007182)2.80616534
37Encephalitis (HP:0002383)2.79768083
38Infertility (HP:0000789)2.79282203
39Disinhibition (HP:0000734)2.78852221
40Subaortic stenosis (HP:0001682)2.77559477
41Abnormality of the left ventricular outflow tract (HP:0011103)2.77559477
42Abnormality of lateral ventricle (HP:0030047)2.75557337
43Hepatosplenomegaly (HP:0001433)2.75110211
44Cortical dysplasia (HP:0002539)2.74302376
45Cellulitis (HP:0100658)2.72677073
46Premature ovarian failure (HP:0008209)2.69627539
47Neuronal loss in central nervous system (HP:0002529)2.69535854
48Breast hypoplasia (HP:0003187)2.68157785
49Recurrent skin infections (HP:0001581)2.66656725
50Volvulus (HP:0002580)2.64288916
51Aplasia/Hypoplasia of the patella (HP:0006498)2.63028296
52Vasculitis (HP:0002633)2.59546416
53Recurrent fungal infections (HP:0002841)2.56464575
54Episodic fever (HP:0001954)2.54378094
55Rib fusion (HP:0000902)2.53103566
56Oligodactyly (hands) (HP:0001180)2.53043833
57Insidious onset (HP:0003587)2.52124402
58Termporal pattern (HP:0011008)2.52124402
59Increased IgM level (HP:0003496)2.49200412
60Abnormal platelet function (HP:0011869)2.46480189
61Impaired platelet aggregation (HP:0003540)2.46480189
62Increased IgE level (HP:0003212)2.45303469
63Arterial tortuosity (HP:0005116)2.41898758
64Midline defect of the nose (HP:0004122)2.40989241
65Mutism (HP:0002300)2.37686428
66Apathy (HP:0000741)2.37154449
67Breast aplasia (HP:0100783)2.34638057
68Diminished motivation (HP:0000745)2.31898189
69Aplasia/Hypoplasia of the breasts (HP:0010311)2.30513964
70Abnormality of iron homeostasis (HP:0011031)2.27289198
71Birth length less than 3rd percentile (HP:0003561)2.26710218
72Chest pain (HP:0100749)2.25837221
73Shawl scrotum (HP:0000049)2.25657178
74Supernumerary spleens (HP:0009799)2.23002488
75Chronic bronchitis (HP:0004469)2.21812656
76Loss of speech (HP:0002371)2.20229620
77Gastrointestinal stroma tumor (HP:0100723)2.20171820
78Abnormality of the heme biosynthetic pathway (HP:0010472)2.17129956
79Recurrent viral infections (HP:0004429)2.16319600
80Gastrointestinal infarctions (HP:0005244)2.14447488
81Ankle clonus (HP:0011448)2.14255931
82Osteomyelitis (HP:0002754)2.12421388
83Abnormality of the phalanges of the hallux (HP:0010057)2.11911382
84Muscle fiber splitting (HP:0003555)2.11859687
85Distal lower limb amyotrophy (HP:0008944)2.11504378
86Muscle stiffness (HP:0003552)2.11356851
87Abnormal gallbladder physiology (HP:0012438)2.11194518
88Cholecystitis (HP:0001082)2.11194518
89Keratoconjunctivitis sicca (HP:0001097)2.10629136
90Deep palmar crease (HP:0006191)2.09047577
91Leukocytosis (HP:0001974)2.08811132
92Upper limb muscle weakness (HP:0003484)2.06295526
93Anterior segment dysgenesis (HP:0007700)2.06207713
94Microglossia (HP:0000171)2.05902510
95Adrenal hypoplasia (HP:0000835)2.03105498
96Genu recurvatum (HP:0002816)2.03027926
97Abnormality of the vasculature of the conjunctiva (HP:0008054)2.02357851
98Asymmetric septal hypertrophy (HP:0001670)2.01827929
99Inappropriate behavior (HP:0000719)1.99509430
100Agammaglobulinemia (HP:0004432)1.99364948
101Aplasia/Hypoplasia of the sternum (HP:0006714)1.98209961
102Exercise-induced muscle cramps (HP:0003710)1.96912262
103Abnormal respiratory motile cilium physiology (HP:0012261)1.96464924
104Vascular tortuosity (HP:0004948)1.96036146
105Heterotopia (HP:0002282)1.95211457
106Amyloidosis (HP:0011034)1.92792292
107Arterial thrombosis (HP:0004420)1.91829727
108Dynein arm defect of respiratory motile cilia (HP:0012255)1.91823379
109Absent/shortened dynein arms (HP:0200106)1.91823379
110Gastrointestinal inflammation (HP:0004386)1.90987577
111Conjunctival telangiectasia (HP:0000524)1.90182822
112Abnormality of the columella (HP:0009929)1.89758091
113Panhypogammaglobulinemia (HP:0003139)1.88325414
114Capillary hemangiomas (HP:0005306)1.88147698
115Increased cerebral lipofuscin (HP:0011813)1.88129408
116Abnormality of chromosome segregation (HP:0002916)1.86776012
117Papilledema (HP:0001085)1.85709969
118Secondary amenorrhea (HP:0000869)1.85632309
119Chronic mucocutaneous candidiasis (HP:0002728)1.85466985
120Recurrent cutaneous fungal infections (HP:0011370)1.85466985
121Fatigue (HP:0012378)1.84797983
122Viral hepatitis (HP:0006562)1.84140826
123Atresia of the external auditory canal (HP:0000413)1.83991904
124Polycythemia (HP:0001901)1.83852736
125Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.82724850
126Chin dimple (HP:0010751)1.82206166
127Amyotrophic lateral sclerosis (HP:0007354)1.81720025
128Inflammation of the large intestine (HP:0002037)1.81168424
129Hypercortisolism (HP:0001578)1.81091309
130Rhabdomyosarcoma (HP:0002859)1.81006495
131Concave nail (HP:0001598)1.80559163
132Keratoconjunctivitis (HP:0001096)1.79640142
133Gingivitis (HP:0000230)1.79634728
134Thyroid carcinoma (HP:0002890)1.79361028
135Sepsis (HP:0100806)1.79356628
136Vertigo (HP:0002321)1.78813688
137Granulocytopenia (HP:0001913)1.77230497
138Bladder neoplasm (HP:0009725)1.76903845
139Bladder carcinoma (HP:0002862)1.76903845
140Primary amenorrhea (HP:0000786)1.75849932
141Glomerulopathy (HP:0100820)1.74896926
142Centrally nucleated skeletal muscle fibers (HP:0003687)1.74286045
143Hyperlipoproteinemia (HP:0010980)1.74142454
144Hypochromic microcytic anemia (HP:0004840)1.71038172
145Abnormality of the corticospinal tract (HP:0002492)1.71006177
146Abnormality of glycolipid metabolism (HP:0010969)1.70787623
147Abnormality of liposaccharide metabolism (HP:0010968)1.70787623
148Abnormality of glycosphingolipid metabolism (HP:0004343)1.70787623
149Hypergammaglobulinemia (HP:0010702)1.70783900
150Medulloblastoma (HP:0002885)1.69520944
151Overlapping toe (HP:0001845)1.69424611
152Pelvic girdle muscle weakness (HP:0003749)1.68869998
153Absent septum pellucidum (HP:0001331)1.68189293
154Transitional cell carcinoma of the bladder (HP:0006740)1.66866712
155Neoplasm of the oral cavity (HP:0100649)1.66657039
156Personality changes (HP:0000751)1.66142050
157Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.63756109
158Short 4th metacarpal (HP:0010044)1.63139649
159Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.63139649
160Supranuclear gaze palsy (HP:0000605)1.62663552
161Genetic anticipation (HP:0003743)1.62609170
162Aplasia involving forearm bones (HP:0009822)1.62162814
163Absent forearm bone (HP:0003953)1.62162814
164Flat capital femoral epiphysis (HP:0003370)1.61893936
165Complete atrioventricular canal defect (HP:0001674)1.60804381
166Cystic hygroma (HP:0000476)1.60473048
167Esophageal atresia (HP:0002032)1.60342227
168Microtia (HP:0008551)1.60266285
169Megalencephaly (HP:0001355)1.60118568
170Acute myeloid leukemia (HP:0004808)1.58841579
171Nonprogressive disorder (HP:0003680)1.58433726
172Absent radius (HP:0003974)1.56982496
173Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.56546162
174Short 1st metacarpal (HP:0010034)1.56546162
175Rhinitis (HP:0012384)1.54207274
176Annular pancreas (HP:0001734)1.54008135
177Shoulder girdle muscle weakness (HP:0003547)1.53912145
178Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.52655509
179Degeneration of the lateral corticospinal tracts (HP:0002314)1.52655509
180Hypoplastic pelvis (HP:0008839)1.52371643
181Absent speech (HP:0001344)1.50625182
182Deviation of the thumb (HP:0009603)1.50603458
183Neoplasm of striated muscle (HP:0009728)1.50067840
184Shallow orbits (HP:0000586)1.49679961
185Abnormality of the 4th metacarpal (HP:0010012)1.49647205
186Abnormality of the musculature of the pelvis (HP:0001469)1.49623526
187Abnormality of the hip-girdle musculature (HP:0001445)1.49623526
188Pendular nystagmus (HP:0012043)1.49433485
189Sandal gap (HP:0001852)1.48560838
190Absent hand (HP:0004050)1.47753955
191Proximal placement of thumb (HP:0009623)1.47612099
192Aqueductal stenosis (HP:0002410)1.47151225
193Leiomyosarcoma (HP:0100243)1.46905089

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK44.21206948
2LATS24.12828220
3LATS13.70896575
4KSR23.56318250
5MAP3K93.43674508
6PRPF4B2.98044820
7MAP3K62.92474893
8PRKD32.80322174
9BLK2.46086350
10MAP2K32.38485514
11SIK32.37406431
12MUSK2.31709504
13KSR12.26160587
14IRAK42.22870645
15DYRK22.19321645
16TESK22.18644677
17TYRO32.17679502
18CDC72.13505043
19NEK22.04491180
20ERBB42.04013510
21STK31.96032880
22MOS1.94502372
23TAOK21.92436612
24MAP4K11.91296376
25DYRK31.84558542
26CHEK21.77232575
27TTK1.69063772
28TAOK11.66839212
29MELK1.66745395
30CSF1R1.65965797
31MARK31.65837162
32PLK41.62209670
33CDK81.57246974
34ARAF1.55459546
35EEF2K1.55071285
36SIK21.54329337
37BTK1.54124427
38RAF11.51537572
39MATK1.50174552
40EPHA31.48767087
41PAK61.45016284
42SYK1.44153834
43STK38L1.43511838
44ICK1.42499858
45IRAK21.39189989
46MAP3K141.39020966
47MARK11.38288596
48CSK1.37940745
49MAP3K41.35825266
50ACVR1B1.34960954
51FES1.34599278
52ZAP701.34445544
53MAPK131.33503404
54TBK11.32643683
55TYK21.31469346
56TAOK31.29019343
57FGR1.27657025
58TNK21.27509024
59EPHB11.27052459
60IRAK31.26101513
61DYRK1B1.24878584
62GRK61.22623846
63HCK1.22617966
64CCNB11.21788620
65MAP3K31.18960093
66PNCK1.16459589
67IRAK11.14803611
68IKBKE1.14576112
69BRAF1.13761886
70WEE11.12593775
71IKBKB1.11263011
72MAP3K101.10152064
73CSNK1G21.09348491
74MAPK121.09048565
75LYN1.03519764
76PLK11.01016711
77TRIM281.00508756
78ERN11.00433986
79CSNK1G10.98079106
80BRD40.97465059
81BUB10.96485284
82CSNK1G30.96347769
83CDK120.93648435
84TEC0.92682291
85DMPK0.92580024
86CDK90.89874274
87JAK30.89461561
88STK380.89049391
89STK100.88063635
90MARK20.87934793
91JAK20.87771113
92PLK30.87608793
93PIM10.85676362
94NTRK20.83732239
95MAP3K80.81624961
96MAPK70.81044794
97MAP3K130.79270430
98RET0.78783087
99AURKA0.77966249
100CSNK1A1L0.77406183
101EPHA40.76057392
102PDK30.72758820
103PDK40.72758820
104PDK20.70252754
105PIK3CG0.69040193
106PIM20.63509563
107PLK20.63453013
108CDK70.61839253
109PDK10.58925984
110MAPK40.58885445
111MAP3K20.58669889
112MAP2K40.58459504
113MAPKAPK30.57808658
114CHEK10.57772308
115CDK60.57485703
116PKN10.57411350
117PRKD20.55571385
118CDK140.54750849
119STK110.52881761
120UHMK10.52212265
121STK390.51380451
122ABL20.50299699
123CDK150.49953542
124AURKB0.49127730
125STK240.48973933
126MAP3K50.48493571
127HIPK20.48126680
128CDK180.48121664
129LCK0.47943710
130RPS6KA40.47315123
131MAP3K110.47286817
132MAP3K10.47046365
133PAK10.46968682
134CDK11A0.46068827
135PDPK10.45878740
136CDK40.45617316
137YES10.45063146
138CDK190.45060773
139* CDK20.44275900
140DDR20.43257436
141BMPR20.42912218
142PTK2B0.42486323
143ATM0.42177213
144KIT0.41170813
145CAMK40.40957040
146PRKD10.40915562
147CHUK0.40870787
148CDK10.40698079
149MAPKAPK50.39935943
150MAPK100.38780209
151CSNK1D0.37943310
152PDGFRA0.37179316
153PDGFRB0.34597374
154FYN0.34077583
155CDC42BPA0.33223912
156TGFBR10.32947446
157BMX0.32620483
158MAP2K70.32569893
159CSNK1E0.32416880
160PAK30.32245493
161CDK50.31730728
162ALK0.31197976
163ERBB30.30785294

Predicted pathways (KEGG)

RankGene SetZ-score
1Cell cycle_Homo sapiens_hsa041102.44898039
2Oocyte meiosis_Homo sapiens_hsa041142.40027994
3Leishmaniasis_Homo sapiens_hsa051402.39308239
4Osteoclast differentiation_Homo sapiens_hsa043802.38823168
5Dorso-ventral axis formation_Homo sapiens_hsa043202.01475174
6Toll-like receptor signaling pathway_Homo sapiens_hsa046201.99231589
7Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.97612822
8Basal transcription factors_Homo sapiens_hsa030221.94591425
9mRNA surveillance pathway_Homo sapiens_hsa030151.93757853
10RNA transport_Homo sapiens_hsa030131.93510258
11Staphylococcus aureus infection_Homo sapiens_hsa051501.89865299
12Tuberculosis_Homo sapiens_hsa051521.88159857
13Allograft rejection_Homo sapiens_hsa053301.85884948
14Colorectal cancer_Homo sapiens_hsa052101.84700075
15Renal cell carcinoma_Homo sapiens_hsa052111.80585880
16Viral myocarditis_Homo sapiens_hsa054161.75195806
17Asthma_Homo sapiens_hsa053101.74974008
18Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.72629397
19Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.70423724
20RNA degradation_Homo sapiens_hsa030181.70115637
21Pancreatic cancer_Homo sapiens_hsa052121.66994582
22Hippo signaling pathway_Homo sapiens_hsa043901.66256610
23Graft-versus-host disease_Homo sapiens_hsa053321.65845041
24TGF-beta signaling pathway_Homo sapiens_hsa043501.64801249
25Acute myeloid leukemia_Homo sapiens_hsa052211.64024982
26VEGF signaling pathway_Homo sapiens_hsa043701.60695661
27Chemokine signaling pathway_Homo sapiens_hsa040621.57536551
28Phagosome_Homo sapiens_hsa041451.57300415
29Autoimmune thyroid disease_Homo sapiens_hsa053201.55414404
30Legionellosis_Homo sapiens_hsa051341.50273400
31MicroRNAs in cancer_Homo sapiens_hsa052061.49819725
32mTOR signaling pathway_Homo sapiens_hsa041501.48132714
33Influenza A_Homo sapiens_hsa051641.45384649
34Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.45187015
35Rheumatoid arthritis_Homo sapiens_hsa053231.44930255
36Herpes simplex infection_Homo sapiens_hsa051681.44451090
37Intestinal immune network for IgA production_Homo sapiens_hsa046721.42482077
38Long-term potentiation_Homo sapiens_hsa047201.42285166
39NOD-like receptor signaling pathway_Homo sapiens_hsa046211.39290433
40Chronic myeloid leukemia_Homo sapiens_hsa052201.35753306
41GnRH signaling pathway_Homo sapiens_hsa049121.34289323
42Salmonella infection_Homo sapiens_hsa051321.34225514
43Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.33265276
44Glioma_Homo sapiens_hsa052141.32159339
45Adherens junction_Homo sapiens_hsa045201.32053188
46Toxoplasmosis_Homo sapiens_hsa051451.31323327
47Type I diabetes mellitus_Homo sapiens_hsa049401.26963796
48Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.26562289
49Endometrial cancer_Homo sapiens_hsa052131.26378966
50NF-kappa B signaling pathway_Homo sapiens_hsa040641.26003498
51Long-term depression_Homo sapiens_hsa047301.24974891
52Hematopoietic cell lineage_Homo sapiens_hsa046401.24835011
53TNF signaling pathway_Homo sapiens_hsa046681.23306038
54Malaria_Homo sapiens_hsa051441.19403509
55Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.19034174
56T cell receptor signaling pathway_Homo sapiens_hsa046601.18673450
57RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.17832577
58Axon guidance_Homo sapiens_hsa043601.17757145
59Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.17281811
60Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.17062455
61Wnt signaling pathway_Homo sapiens_hsa043101.16939929
62Non-small cell lung cancer_Homo sapiens_hsa052231.16840318
63Spliceosome_Homo sapiens_hsa030401.15323750
64ErbB signaling pathway_Homo sapiens_hsa040121.14741648
65Primary immunodeficiency_Homo sapiens_hsa053401.14205927
66SNARE interactions in vesicular transport_Homo sapiens_hsa041301.13826098
67Estrogen signaling pathway_Homo sapiens_hsa049151.12838873
68Choline metabolism in cancer_Homo sapiens_hsa052311.12652020
69Pertussis_Homo sapiens_hsa051331.12108932
70Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.11203608
71Apoptosis_Homo sapiens_hsa042101.10391937
72Measles_Homo sapiens_hsa051621.07965206
73p53 signaling pathway_Homo sapiens_hsa041151.07790008
74RNA polymerase_Homo sapiens_hsa030201.07270165
75Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.05357251
76Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.04711218
77Tight junction_Homo sapiens_hsa045301.03847784
78Circadian rhythm_Homo sapiens_hsa047101.03322292
79Gap junction_Homo sapiens_hsa045401.02563258
80Shigellosis_Homo sapiens_hsa051311.00843398
81Ovarian steroidogenesis_Homo sapiens_hsa049131.00670224
82Hedgehog signaling pathway_Homo sapiens_hsa043400.99550918
83Bladder cancer_Homo sapiens_hsa052190.97017567
84Thyroid hormone signaling pathway_Homo sapiens_hsa049190.96589105
85MAPK signaling pathway_Homo sapiens_hsa040100.96537421
86FoxO signaling pathway_Homo sapiens_hsa040680.95212599
87Ras signaling pathway_Homo sapiens_hsa040140.91817009
88Collecting duct acid secretion_Homo sapiens_hsa049660.91694675
89Sphingolipid signaling pathway_Homo sapiens_hsa040710.91586632
90Thyroid cancer_Homo sapiens_hsa052160.91546767
91Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.91521503
92Prostate cancer_Homo sapiens_hsa052150.91206236
93Phospholipase D signaling pathway_Homo sapiens_hsa040720.91121050
94Fanconi anemia pathway_Homo sapiens_hsa034600.89931750
95Longevity regulating pathway - mammal_Homo sapiens_hsa042110.88595241
96Regulation of actin cytoskeleton_Homo sapiens_hsa048100.87112005
97Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.86212868
98Endocytosis_Homo sapiens_hsa041440.86031835
99Vitamin B6 metabolism_Homo sapiens_hsa007500.85772667
100Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.85543203
101Neurotrophin signaling pathway_Homo sapiens_hsa047220.85454373
102Basal cell carcinoma_Homo sapiens_hsa052170.85012566
103Dopaminergic synapse_Homo sapiens_hsa047280.84919855
104Prolactin signaling pathway_Homo sapiens_hsa049170.83774978
105Melanogenesis_Homo sapiens_hsa049160.83435677
106Small cell lung cancer_Homo sapiens_hsa052220.82881871
107Melanoma_Homo sapiens_hsa052180.82333375
108Antigen processing and presentation_Homo sapiens_hsa046120.82195147
109Oxytocin signaling pathway_Homo sapiens_hsa049210.81502587
110Jak-STAT signaling pathway_Homo sapiens_hsa046300.80022144
111Ether lipid metabolism_Homo sapiens_hsa005650.79512223
112Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.78161516
113Leukocyte transendothelial migration_Homo sapiens_hsa046700.77242523
114Glutamatergic synapse_Homo sapiens_hsa047240.76960716
115Lysosome_Homo sapiens_hsa041420.76241355
116Alcoholism_Homo sapiens_hsa050340.74572601
117Amphetamine addiction_Homo sapiens_hsa050310.74322608
118Hepatitis C_Homo sapiens_hsa051600.73070867
119Rap1 signaling pathway_Homo sapiens_hsa040150.72903295
120Pathways in cancer_Homo sapiens_hsa052000.72077850
121HTLV-I infection_Homo sapiens_hsa051660.71802425
122Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.71461450
123Nucleotide excision repair_Homo sapiens_hsa034200.70755435
124Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.70389045
125Hepatitis B_Homo sapiens_hsa051610.70107452
126Synaptic vesicle cycle_Homo sapiens_hsa047210.69691020
127Regulation of autophagy_Homo sapiens_hsa041400.68659321
128Proteoglycans in cancer_Homo sapiens_hsa052050.68400883
129Base excision repair_Homo sapiens_hsa034100.67269134
130Transcriptional misregulation in cancer_Homo sapiens_hsa052020.66722187
131Olfactory transduction_Homo sapiens_hsa047400.66611434
132Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.65985815
133Homologous recombination_Homo sapiens_hsa034400.64935280
134Viral carcinogenesis_Homo sapiens_hsa052030.64827394
135Notch signaling pathway_Homo sapiens_hsa043300.64681601
136B cell receptor signaling pathway_Homo sapiens_hsa046620.63563445
137Epstein-Barr virus infection_Homo sapiens_hsa051690.63126290
138Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.63094269
139Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.58019241
140AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.57336210
141Type II diabetes mellitus_Homo sapiens_hsa049300.56150200
142Amoebiasis_Homo sapiens_hsa051460.55858053
143Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.54567590
144Other glycan degradation_Homo sapiens_hsa005110.54058811
145Cocaine addiction_Homo sapiens_hsa050300.53798529
146Systemic lupus erythematosus_Homo sapiens_hsa053220.53409767
147Platelet activation_Homo sapiens_hsa046110.52665842
148Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.52357594
149Central carbon metabolism in cancer_Homo sapiens_hsa052300.52187704
150HIF-1 signaling pathway_Homo sapiens_hsa040660.52160239
151Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.52045837
152cAMP signaling pathway_Homo sapiens_hsa040240.51396022
153Focal adhesion_Homo sapiens_hsa045100.49922225
154Cholinergic synapse_Homo sapiens_hsa047250.49646978
155African trypanosomiasis_Homo sapiens_hsa051430.49542767
156cGMP-PKG signaling pathway_Homo sapiens_hsa040220.49415612
157Phosphatidylinositol signaling system_Homo sapiens_hsa040700.49247855
158AMPK signaling pathway_Homo sapiens_hsa041520.47859611
159Insulin signaling pathway_Homo sapiens_hsa049100.47637763
160Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.45292228

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