AKIRIN1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of gene silencing by RNA (GO:0060966)6.15889639
2regulation of posttranscriptional gene silencing (GO:0060147)6.15889639
3regulation of gene silencing by miRNA (GO:0060964)6.15889639
4establishment of integrated proviral latency (GO:0075713)5.76560225
5pre-miRNA processing (GO:0031054)5.23816700
6protein complex localization (GO:0031503)4.86963839
7establishment of viral latency (GO:0019043)4.65207650
8COPI coating of Golgi vesicle (GO:0048205)4.58200185
9Golgi transport vesicle coating (GO:0048200)4.58200185
10heterochromatin organization (GO:0070828)4.52684236
11paraxial mesoderm development (GO:0048339)4.30099275
12L-serine metabolic process (GO:0006563)4.23102142
13histone arginine methylation (GO:0034969)4.16916605
14regulation of early endosome to late endosome transport (GO:2000641)4.13795460
15protein localization to kinetochore (GO:0034501)4.07172359
16nuclear pore complex assembly (GO:0051292)4.06776528
17Arp2/3 complex-mediated actin nucleation (GO:0034314)4.00406534
18cellular protein complex localization (GO:0034629)3.99180041
19DNA unwinding involved in DNA replication (GO:0006268)3.92409025
20natural killer cell mediated immunity (GO:0002228)3.89622121
21natural killer cell mediated cytotoxicity (GO:0042267)3.89622121
22regulation of histone H3-K9 methylation (GO:0051570)3.85554986
23negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.83595173
24regulation of helicase activity (GO:0051095)3.83367236
25cell fate commitment involved in formation of primary germ layer (GO:0060795)3.77649836
26chromatin remodeling at centromere (GO:0031055)3.76487167
27protein localization to chromosome, centromeric region (GO:0071459)3.72467100
28IMP biosynthetic process (GO:0006188)3.72150500
29modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.69524400
30positive regulation by organism of defense response of other organism involved in symbiotic interact3.69524400
31modulation by symbiont of host immune response (GO:0052553)3.69524400
32positive regulation by symbiont of host defense response (GO:0052509)3.69524400
33modulation by symbiont of host defense response (GO:0052031)3.69524400
34modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.69524400
35nuclear pore organization (GO:0006999)3.68947089
36DNA damage response, detection of DNA damage (GO:0042769)3.67770446
37CENP-A containing nucleosome assembly (GO:0034080)3.67178934
38DNA replication-independent nucleosome assembly (GO:0006336)3.65668153
39DNA replication-independent nucleosome organization (GO:0034724)3.65668153
40localization within membrane (GO:0051668)3.65190206
41formation of translation preinitiation complex (GO:0001731)3.62215293
42positive regulation of SMAD protein import into nucleus (GO:0060391)3.59641478
43peptidyl-arginine omega-N-methylation (GO:0035247)3.58051549
44antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.55036048
45negative regulation of RNA splicing (GO:0033119)3.52142830
46regulation of cell fate specification (GO:0042659)3.51742311
47negative regulation of histone methylation (GO:0031061)3.47806733
48neutrophil activation involved in immune response (GO:0002283)3.45767883
49antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.45115868
50antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.45115868
51IMP metabolic process (GO:0046040)3.43278826
52ATP-dependent chromatin remodeling (GO:0043044)3.42566648
53protein localization to endosome (GO:0036010)3.40381751
54peptidyl-arginine methylation (GO:0018216)3.35866862
55peptidyl-arginine N-methylation (GO:0035246)3.35866862
56negative regulation of gene silencing (GO:0060969)3.33139191
57protein maturation by protein folding (GO:0022417)3.29135555
58mitotic metaphase plate congression (GO:0007080)3.27826858
59negative regulation of mRNA processing (GO:0050686)3.26849998
60antigen processing and presentation of endogenous antigen (GO:0019883)3.24856390
61activated T cell proliferation (GO:0050798)3.18615617
62negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.18462202
63negative regulation of cell killing (GO:0031342)3.18462202
64RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)3.17564379
65mRNA splicing, via spliceosome (GO:0000398)3.17564379
66regulation of gene silencing (GO:0060968)3.17325014
67positive regulation of autophagy (GO:0010508)3.16438046
68DNA strand elongation involved in DNA replication (GO:0006271)3.15802086
69cellular response to arsenic-containing substance (GO:0071243)3.15677017
70RNA splicing, via transesterification reactions (GO:0000375)3.14539760
71positive regulation of oligodendrocyte differentiation (GO:0048714)3.13622416
72purine nucleobase biosynthetic process (GO:0009113)3.13590657
73histone exchange (GO:0043486)3.12594313
74actin nucleation (GO:0045010)3.10838862
75regulation of mitotic spindle checkpoint (GO:1903504)3.10695468
76regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.10695468
77negative regulation of mRNA metabolic process (GO:1903312)3.08191164
78negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.08162282
79negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.08162282
80negative regulation of mitotic sister chromatid segregation (GO:0033048)3.08162282
81negative regulation of mitotic sister chromatid separation (GO:2000816)3.08162282
82negative regulation of sister chromatid segregation (GO:0033046)3.08162282
83termination of RNA polymerase II transcription (GO:0006369)3.06645809
84negative regulation of chromosome segregation (GO:0051985)3.06535515
85regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.05988647
86ribosome assembly (GO:0042255)3.05794120
87response to nerve growth factor (GO:1990089)3.03934426
88cellular response to nerve growth factor stimulus (GO:1990090)3.03934426
89DNA strand elongation (GO:0022616)3.03474437
90respiratory burst (GO:0045730)3.01691324
91mRNA splice site selection (GO:0006376)3.01492021
92regulation of translation, ncRNA-mediated (GO:0045974)3.01428557
93negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.01428557
94negative regulation of translation, ncRNA-mediated (GO:0040033)3.01428557
95negative regulation of interleukin-17 production (GO:0032700)3.01382316
96ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)3.00992019
97DNA topological change (GO:0006265)3.00354745
98nucleosome disassembly (GO:0006337)2.99907016
99protein-DNA complex disassembly (GO:0032986)2.99907016
100signal peptide processing (GO:0006465)2.97287164
101mRNA stabilization (GO:0048255)2.96807628
102RNA stabilization (GO:0043489)2.96807628
103regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.94356759
104regulation of mRNA stability (GO:0043488)2.91946607
105sequestering of actin monomers (GO:0042989)2.88680732
106DNA ligation (GO:0006266)2.87596385
107DNA replication checkpoint (GO:0000076)2.86255448
108serine family amino acid biosynthetic process (GO:0009070)2.86231984
109DNA replication-dependent nucleosome assembly (GO:0006335)2.83921244
110DNA replication-dependent nucleosome organization (GO:0034723)2.83921244
111response to peptidoglycan (GO:0032494)2.83227986
112leukocyte mediated cytotoxicity (GO:0001909)2.82889998
113regulation of chromosome segregation (GO:0051983)2.81996678
114negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.79091024
115spliceosomal snRNP assembly (GO:0000387)2.78954365
116chromatin assembly or disassembly (GO:0006333)2.78907294
117negative regulation of glycoprotein biosynthetic process (GO:0010561)2.78014793
118convergent extension (GO:0060026)2.76953773
119ribosomal small subunit assembly (GO:0000028)2.76860875
120retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.75487216
121nucleobase biosynthetic process (GO:0046112)2.75463438
122positive regulation of lamellipodium assembly (GO:0010592)2.74850033
123mitotic spindle checkpoint (GO:0071174)2.74172395
124regulation of chromatin silencing (GO:0031935)2.72901143
125lung-associated mesenchyme development (GO:0060484)2.71985140
126pore complex assembly (GO:0046931)2.71017133
127regulation of RNA stability (GO:0043487)2.70349181
128ribosomal large subunit biogenesis (GO:0042273)2.70338029
129low-density lipoprotein particle clearance (GO:0034383)2.69558039
130regulation of mitochondrial translation (GO:0070129)2.68694910
131mitotic spindle assembly checkpoint (GO:0007094)2.68521895
132spindle checkpoint (GO:0031577)2.68111415
133regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.66429903
134regulation of mitotic metaphase/anaphase transition (GO:0030071)2.66429903
135regulation of translational fidelity (GO:0006450)2.65386751
136nerve growth factor signaling pathway (GO:0038180)2.65315129
137positive regulation of leukocyte degranulation (GO:0043302)2.64856406
138chromatin assembly (GO:0031497)2.64680326
139somatic diversification of immune receptors via somatic mutation (GO:0002566)2.64495495
140somatic hypermutation of immunoglobulin genes (GO:0016446)2.64495495
141positive regulation of chromosome segregation (GO:0051984)2.64089890
142spindle assembly checkpoint (GO:0071173)2.63458168
143G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.63104291
144glycosphingolipid catabolic process (GO:0046479)2.62882084
145negative regulation of phosphoprotein phosphatase activity (GO:0032515)2.62147819
146regulation of mitotic sister chromatid segregation (GO:0033047)2.61723609
147JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.61722792
148immunoglobulin mediated immune response (GO:0016064)2.61707478
149activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.61025873
150positive regulation of nuclease activity (GO:0032075)2.56920183
151autophagic vacuole assembly (GO:0000045)2.56222423
152positive regulation of actin filament depolymerization (GO:0030836)2.54799964
153granulocyte activation (GO:0036230)2.54183573
154membrane budding (GO:0006900)2.53804360
155leukocyte aggregation (GO:0070486)2.52432941
156positive regulation of macroautophagy (GO:0016239)2.52142040
157Rap protein signal transduction (GO:0032486)2.51929088
158macrophage activation involved in immune response (GO:0002281)2.50662475
159regulation of type B pancreatic cell apoptotic process (GO:2000674)2.48716389
160sexual reproduction (GO:0019953)2.47356994
161eosinophil chemotaxis (GO:0048245)2.46424637
162regulation of nuclease activity (GO:0032069)2.45585250
163endoplasmic reticulum unfolded protein response (GO:0030968)2.45363970
164regulation of podosome assembly (GO:0071801)2.43095325
165myeloid cell homeostasis (GO:0002262)2.42268770
166neutrophil activation (GO:0042119)2.40251420
167negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.39454597
168intestinal epithelial cell development (GO:0060576)2.38330183
169negative regulation of inclusion body assembly (GO:0090084)2.37337220
170glycolipid catabolic process (GO:0019377)2.36309682
171regulation of translational termination (GO:0006449)2.35897914
172ER overload response (GO:0006983)2.35590923
173cellular response to unfolded protein (GO:0034620)2.35390280
174cortical actin cytoskeleton organization (GO:0030866)2.35243488
175regulation of interferon-beta biosynthetic process (GO:0045357)2.34451550
176sequestering of metal ion (GO:0051238)2.33596640
177Fc receptor mediated stimulatory signaling pathway (GO:0002431)2.33127928
178positive regulation of mast cell activation (GO:0033005)2.31712007
179neurofilament cytoskeleton organization (GO:0060052)2.29248322
180phagosome maturation (GO:0090382)2.28234795
181hydrogen peroxide biosynthetic process (GO:0050665)2.28055458
182regulation of interleukin-17 production (GO:0032660)2.27216039
183immune response-regulating cell surface receptor signaling pathway involved in phagocytosis (GO:00022.26815068
184Fc-gamma receptor signaling pathway (GO:0038094)2.26815068
185Fc-gamma receptor signaling pathway involved in phagocytosis (GO:0038096)2.26815068
186production of molecular mediator involved in inflammatory response (GO:0002532)2.26363010
187magnesium ion transport (GO:0015693)2.26285797
188regulation of defense response to virus by virus (GO:0050690)2.25500604
189ER-nucleus signaling pathway (GO:0006984)2.25267187
190regulation of interferon-gamma biosynthetic process (GO:0045072)2.24597441
191response to host immune response (GO:0052572)2.23032175
192response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.23032175
193interferon-gamma secretion (GO:0072643)2.22883085
194sphingolipid catabolic process (GO:0030149)2.22373061
195cellular response to topologically incorrect protein (GO:0035967)2.22370801
196ceramide catabolic process (GO:0046514)2.21543499
197positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.20722318
198regulation of histone phosphorylation (GO:0033127)2.20556352
199positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.19728235
200regulation of lipopolysaccharide-mediated signaling pathway (GO:0031664)2.19686004

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.96084237
2EGR1_19374776_ChIP-ChIP_THP-1_Human4.86430253
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.32494069
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.89102296
5NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.71144622
6HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.03554004
7MYC_19079543_ChIP-ChIP_MESCs_Mouse3.01480607
8IRF8_21731497_ChIP-ChIP_J774_Mouse3.00895103
9FOXM1_23109430_ChIP-Seq_U2OS_Human2.98761015
10E2F4_17652178_ChIP-ChIP_JURKAT_Human2.92694632
11NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.89762028
12KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.85853412
13KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.85853412
14KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.85853412
15MYC_19030024_ChIP-ChIP_MESCs_Mouse2.84874683
16IRF8_27001747_Chip-Seq_BMDM_Mouse2.84666872
17KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.75657246
18IRF8_22096565_ChIP-ChIP_GC-B_Human2.74611839
19FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.74148668
20MYB_21317192_ChIP-Seq_ERMYB_Mouse2.74091790
21CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.69664445
22NELFA_20434984_ChIP-Seq_ESCs_Mouse2.64434864
23SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.63003965
24FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.54525965
25ZNF263_19887448_ChIP-Seq_K562_Human2.47526700
26MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.42292556
27MYC_18358816_ChIP-ChIP_MESCs_Mouse2.40653195
28NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.38794753
29XRN2_22483619_ChIP-Seq_HELA_Human2.37394246
30* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.37185758
31THAP11_20581084_ChIP-Seq_MESCs_Mouse2.31529967
32STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.28713733
33NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.28681319
34MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.26658520
35* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.23314578
36MYCN_18555785_ChIP-Seq_MESCs_Mouse2.20405532
37POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.16848463
38POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.14635548
39TTF2_22483619_ChIP-Seq_HELA_Human2.12424785
40YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.11847633
41EST1_17652178_ChIP-ChIP_JURKAT_Human2.10575058
42TFEB_21752829_ChIP-Seq_HELA_Human2.08602354
43ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.07454693
44RBPJ_22232070_ChIP-Seq_NCS_Mouse2.05627559
45GABP_17652178_ChIP-ChIP_JURKAT_Human2.01308787
46SOX2_18555785_ChIP-Seq_MESCs_Mouse2.01051866
47E2F1_18555785_ChIP-Seq_MESCs_Mouse2.00807065
48ETS1_20019798_ChIP-Seq_JURKAT_Human2.00524411
49HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.93533088
50SOX2_16153702_ChIP-ChIP_HESCs_Human1.93196173
51MYB_26560356_Chip-Seq_TH2_Human1.93075524
52GATA3_27048872_Chip-Seq_THYMUS_Human1.92316043
53RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.92188175
54JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.91788359
55CLOCK_20551151_ChIP-Seq_293T_Human1.91157447
56SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.87175781
57MYC_22102868_ChIP-Seq_BL_Human1.84972390
58BRD4_27068464_Chip-Seq_AML-cells_Mouse1.80023476
59STAT6_21828071_ChIP-Seq_BEAS2B_Human1.79575556
60SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.79290613
61SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.77779056
62MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.77168485
63DCP1A_22483619_ChIP-Seq_HELA_Human1.76480473
64* SPI1_23547873_ChIP-Seq_NB4_Human1.75711939
65CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.75504244
66ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.75023151
67NANOG_16153702_ChIP-ChIP_HESCs_Human1.72903589
68PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.71949484
69NANOG_18555785_ChIP-Seq_MESCs_Mouse1.70358948
70NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.69584825
71SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.68384383
72MAF_26560356_Chip-Seq_TH1_Human1.67723956
73ELK1_19687146_ChIP-ChIP_HELA_Human1.67229905
74E2F1_21310950_ChIP-Seq_MCF-7_Human1.66123571
75NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.65809417
76VDR_21846776_ChIP-Seq_THP-1_Human1.65479889
77* VDR_24763502_ChIP-Seq_THP-1_Human1.64750924
78TCF3_18692474_ChIP-Seq_MEFs_Mouse1.64647904
79* KDM2B_26808549_Chip-Seq_DND41_Human1.63739673
80* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.62879597
81EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.61048977
82FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.59226534
83TRIM28_21343339_ChIP-Seq_HEK293_Human1.58487785
84FOXP3_21729870_ChIP-Seq_TREG_Human1.58451034
85ATF3_27146783_Chip-Seq_COLON_Human1.57579172
86FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.57219905
87POU5F1_16153702_ChIP-ChIP_HESCs_Human1.56808606
88MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.56723756
89E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.56704862
90GABP_19822575_ChIP-Seq_HepG2_Human1.55292460
91STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.54125314
92RUNX1_22412390_ChIP-Seq_EML_Mouse1.53806170
93YY1_21170310_ChIP-Seq_MESCs_Mouse1.53235248
94IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.52327782
95KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.51737064
96CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.51315387
97NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.51243937
98ELK3_25401928_ChIP-Seq_HUVEC_Human1.50656232
99E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.48789713
100AR_21909140_ChIP-Seq_LNCAP_Human1.47189138
101STAT4_19710469_ChIP-ChIP_TH1__Mouse1.44230719
102* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.42684138
103NANOG_21062744_ChIP-ChIP_HESCs_Human1.42320431
104POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.42063550
105ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.41668440
106SALL1_21062744_ChIP-ChIP_HESCs_Human1.40740775
107KLF4_18555785_ChIP-Seq_MESCs_Mouse1.38456079
108FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.38271664
109RUNX_20019798_ChIP-Seq_JUKART_Human1.37490888
110* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.37117855
111CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.36549486
112KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.36197293
113* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.35278068
114FOXO3_23340844_ChIP-Seq_DLD1_Human1.34477970
115KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.34466689
116MYB_26560356_Chip-Seq_TH1_Human1.34402520
117HOXB4_20404135_ChIP-ChIP_EML_Mouse1.33548708
118TCF7_22412390_ChIP-Seq_EML_Mouse1.33478090
119ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.30922390
120HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.28746794
121PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.28377879
122TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.27634794
123TCF3_18692474_ChIP-Seq_MESCs_Mouse1.26771112
124* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.26228214
125GATA1_26923725_Chip-Seq_HPCs_Mouse1.26020562
126PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.25892313
127* UTX_26944678_Chip-Seq_JUKART_Human1.25790696
128TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.25570039
129NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.25235685
130* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.24573155
131VDR_23849224_ChIP-Seq_CD4+_Human1.24453302
132TP63_17297297_ChIP-ChIP_HaCaT_Human1.23616783
133KDM2B_26808549_Chip-Seq_SUP-B15_Human1.23211861
134SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.23117365
135PU_27001747_Chip-Seq_BMDM_Mouse1.22697756
136* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.22530150
137* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.21872646
138ZFP281_18757296_ChIP-ChIP_E14_Mouse1.21827581
139PADI4_21655091_ChIP-ChIP_MCF-7_Human1.21453601
140TP63_19390658_ChIP-ChIP_HaCaT_Human1.21419533
141WT1_19549856_ChIP-ChIP_CCG9911_Human1.21027503
142SOX2_18692474_ChIP-Seq_MEFs_Mouse1.20301183
143DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.19753021
144PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.18751745
145SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.17023169
146SPI1_23127762_ChIP-Seq_K562_Human1.16754349
147MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.15683120
148STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.15498261
149ELK1_22589737_ChIP-Seq_MCF10A_Human1.15433730
150ZFX_18555785_ChIP-Seq_MESCs_Mouse1.15202692
151SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.15151141
152MYC_18940864_ChIP-ChIP_HL60_Human1.14878188
153* CHD1_26751641_Chip-Seq_LNCaP_Human1.14853186
154EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.14156284
155* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.13891952
156CREB1_15753290_ChIP-ChIP_HEK293T_Human1.09302604
157* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.08727474
158SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.08674630
159POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.08622919
160UBF1/2_26484160_Chip-Seq_HMECs_Human1.08265705
161RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.08084875
162TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.07021554
163ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.06944855
164NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.05892604
165OCT4_18692474_ChIP-Seq_MEFs_Mouse1.03074903
166* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.02098557
167TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.01891966
168SOX17_20123909_ChIP-Seq_XEN_Mouse1.01678807
169P63_26484246_Chip-Seq_KERATINOCYTES_Human1.00233346
170TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.98549802
171RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97952167
172RACK7_27058665_Chip-Seq_MCF-7_Human0.97362572
173RARG_19884340_ChIP-ChIP_MEFs_Mouse0.95962635
174GATA3_26560356_Chip-Seq_TH2_Human0.94539347
175LXR_22292898_ChIP-Seq_THP-1_Human0.94238411
176TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.94108118
177CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.94008985
178CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.93087855
179SOX2_27498859_Chip-Seq_STOMACH_Mouse0.92782335
180PKCTHETA_26484144_Chip-Seq_BREAST_Human0.92772174
181* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.92349548
182* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.92144060
183JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.92072440
184* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.91708543
185SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.90960454

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation4.01460735
2MP0004957_abnormal_blastocyst_morpholog3.58173382
3MP0005058_abnormal_lysosome_morphology3.27611597
4MP0003111_abnormal_nucleus_morphology3.11832675
5MP0003436_decreased_susceptibility_to2.98538909
6MP0003890_abnormal_embryonic-extraembry2.97985959
7MP0002254_reproductive_system_inflammat2.95683231
8MP0002877_abnormal_melanocyte_morpholog2.71700630
9MP0008932_abnormal_embryonic_tissue2.67281382
10MP0006082_CNS_inflammation2.65216741
11MP0009840_abnormal_foam_cell2.64905091
12MP0003567_abnormal_fetal_cardiomyocyte2.63683471
13MP0009672_abnormal_birth_weight2.63155841
14MP0005000_abnormal_immune_tolerance2.59461367
15MP0003941_abnormal_skin_development2.58099769
16MP0003300_gastrointestinal_ulcer2.54997245
17MP0001293_anophthalmia2.54488302
18MP0003172_abnormal_lysosome_physiology2.52791029
19MP0010094_abnormal_chromosome_stability2.51311497
20MP0003122_maternal_imprinting2.45561926
21MP0003077_abnormal_cell_cycle2.45180514
22MP0006292_abnormal_olfactory_placode2.44789660
23MP0010234_abnormal_vibrissa_follicle2.34122975
24MP0001529_abnormal_vocalization2.32826735
25MP0008058_abnormal_DNA_repair2.31111383
26MP0000604_amyloidosis2.30167093
27MP0001730_embryonic_growth_arrest2.28307283
28MP0008877_abnormal_DNA_methylation2.25936454
29MP0001835_abnormal_antigen_presentation2.23139001
30MP0003329_amyloid_beta_deposits2.17786142
31MP0003183_abnormal_peptide_metabolism2.11662734
32MP0002148_abnormal_hypersensitivity_rea2.10612305
33MP0004947_skin_inflammation2.04199618
34MP0002697_abnormal_eye_size2.02173418
35MP0000537_abnormal_urethra_morphology2.00630985
36MP0004510_myositis1.97923119
37MP0001188_hyperpigmentation1.96508539
38MP0002419_abnormal_innate_immunity1.94718029
39MP0003136_yellow_coat_color1.92228812
40MP0001790_abnormal_immune_system1.92108618
41MP0005387_immune_system_phenotype1.92108618
42MP0002723_abnormal_immune_serum1.90273475
43MP0002452_abnormal_antigen_presenting1.89173637
44MP0003937_abnormal_limbs/digits/tail_de1.89140993
45MP0008260_abnormal_autophagy1.88902767
46MP0003119_abnormal_digestive_system1.87457507
47MP0002084_abnormal_developmental_patter1.86574198
48MP0000685_abnormal_immune_system1.84122783
49MP0002085_abnormal_embryonic_tissue1.83888239
50MP0005671_abnormal_response_to1.83302309
51MP0000350_abnormal_cell_proliferation1.83268121
52MP0001672_abnormal_embryogenesis/_devel1.78319436
53MP0005380_embryogenesis_phenotype1.78319436
54MP0001800_abnormal_humoral_immune1.78020321
55MP0001533_abnormal_skeleton_physiology1.77556854
56MP0003121_genomic_imprinting1.77104262
57MP0008057_abnormal_DNA_replication1.76687710
58MP0004133_heterotaxia1.73659038
59MP0001819_abnormal_immune_cell1.72715352
60MP0002420_abnormal_adaptive_immunity1.71288815
61MP0009785_altered_susceptibility_to1.70178685
62MP0002405_respiratory_system_inflammati1.69981766
63MP0001697_abnormal_embryo_size1.68775219
64MP0009333_abnormal_splenocyte_physiolog1.68632814
65MP0002693_abnormal_pancreas_physiology1.67624396
66MP0005025_abnormal_response_to1.62470637
67MP0001286_abnormal_eye_development1.61381920
68MP0004197_abnormal_fetal_growth/weight/1.60805721
69MP0000049_abnormal_middle_ear1.58799182
70MP0008007_abnormal_cellular_replicative1.57649653
71MP0005499_abnormal_olfactory_system1.55989863
72MP0005394_taste/olfaction_phenotype1.55989863
73MP0009703_decreased_birth_body1.55727615
74MP0003984_embryonic_growth_retardation1.55324462
75MP0000566_synostosis1.55109963
76MP0005310_abnormal_salivary_gland1.54950445
77MP0003221_abnormal_cardiomyocyte_apopto1.54277297
78MP0010352_gastrointestinal_tract_polyps1.53352045
79MP0003861_abnormal_nervous_system1.51757198
80MP0002088_abnormal_embryonic_growth/wei1.51081407
81MP0002653_abnormal_ependyma_morphology1.47736275
82MP0003718_maternal_effect1.44263213
83MP0000778_abnormal_nervous_system1.43649680
84MP0003123_paternal_imprinting1.42650098
85MP0003448_altered_tumor_morphology1.41542402
86MP0002080_prenatal_lethality1.40792255
87MP0003693_abnormal_embryo_hatching1.40637589
88MP0010030_abnormal_orbit_morphology1.39855131
89MP0002092_abnormal_eye_morphology1.39583785
90MP0000920_abnormal_myelination1.37685256
91MP0001845_abnormal_inflammatory_respons1.37182400
92MP0001299_abnormal_eye_distance/1.36812970
93MP0003091_abnormal_cell_migration1.35965661
94MP0000013_abnormal_adipose_tissue1.34659617
95MP0001984_abnormal_olfaction1.32533049
96MP0002909_abnormal_adrenal_gland1.32195608
97MP0006035_abnormal_mitochondrial_morpho1.31374654
98MP0003315_abnormal_perineum_morphology1.30886236
99MP0001851_eye_inflammation1.30628821
100MP0003191_abnormal_cellular_cholesterol1.29851495
101MP0000716_abnormal_immune_system1.29076910
102MP0002233_abnormal_nose_morphology1.28325015
103MP0005076_abnormal_cell_differentiation1.27950266
104MP0003634_abnormal_glial_cell1.27906550
105MP0003690_abnormal_glial_cell1.27056526
106MP0008789_abnormal_olfactory_epithelium1.26537189
107MP0003566_abnormal_cell_adhesion1.26179875
108MP0002638_abnormal_pupillary_reflex1.25303421
109MP0005645_abnormal_hypothalamus_physiol1.24401314
110MP0000858_altered_metastatic_potential1.23621998
111MP0002111_abnormal_tail_morphology1.21927242
112MP0002398_abnormal_bone_marrow1.21273564
113MP0003195_calcinosis1.17215375
114MP0001944_abnormal_pancreas_morphology1.16765180
115MP0003453_abnormal_keratinocyte_physiol1.14922502
116MP0000313_abnormal_cell_death1.13381425
117MP0004858_abnormal_nervous_system1.12985827
118MP0003938_abnormal_ear_development1.11757487
119MP0002102_abnormal_ear_morphology1.08653509
120MP0003724_increased_susceptibility_to1.07633350
121MP0000428_abnormal_craniofacial_morphol1.06747492
122MP0004742_abnormal_vestibular_system1.06714436
123MP0002086_abnormal_extraembryonic_tissu1.05592532
124MP0004270_analgesia1.05213424
125MP0009697_abnormal_copulation1.04959535
126MP0005464_abnormal_platelet_physiology1.04660713
127MP0010678_abnormal_skin_adnexa1.03542684
128MP0003787_abnormal_imprinting1.02567783
129MP0003763_abnormal_thymus_physiology1.01257511
130MP0003115_abnormal_respiratory_system0.98442101
131MP0004185_abnormal_adipocyte_glucose0.97235251
132MP0002933_joint_inflammation0.95016457
133MP0002429_abnormal_blood_cell0.94963946
134MP0000465_gastrointestinal_hemorrhage0.93477671
135MP0002998_abnormal_bone_remodeling0.92781029
136MP0010155_abnormal_intestine_physiology0.92424961
137MP0001849_ear_inflammation0.92329322
138MP0000689_abnormal_spleen_morphology0.92031590
139MP0002722_abnormal_immune_system0.91042208
140MP0001727_abnormal_embryo_implantation0.90564549
141MP0003755_abnormal_palate_morphology0.90270030
142MP0009278_abnormal_bone_marrow0.89656394
143MP0001915_intracranial_hemorrhage0.89027827
144MP0002081_perinatal_lethality0.88829704
145MP0010386_abnormal_urinary_bladder0.88314548
146MP0002938_white_spotting0.87945176
147MP0002152_abnormal_brain_morphology0.86392432
148MP0010307_abnormal_tumor_latency0.85541031
149MP0005391_vision/eye_phenotype0.84849686
150MP0002009_preneoplasia0.84125119
151MP0001542_abnormal_bone_strength0.84041162
152MP0008469_abnormal_protein_level0.83694415
153MP0003878_abnormal_ear_physiology0.83052250
154MP0005377_hearing/vestibular/ear_phenot0.83052250
155MP0004811_abnormal_neuron_physiology0.80853447
156MP0000432_abnormal_head_morphology0.80804913
157MP0003942_abnormal_urinary_system0.79833681
158MP0003866_abnormal_defecation0.79750020
159MP0000955_abnormal_spinal_cord0.79089829
160MP0001853_heart_inflammation0.78421434
161MP0005621_abnormal_cell_physiology0.77941121
162MP0002751_abnormal_autonomic_nervous0.76307251
163MP0003795_abnormal_bone_structure0.76249664
164MP0000358_abnormal_cell_content/0.75501548
165MP0000343_altered_response_to0.75466415
166MP0003385_abnormal_body_wall0.74922152
167MP0002089_abnormal_postnatal_growth/wei0.74891886
168MP0003656_abnormal_erythrocyte_physiolo0.73924591
169MP0002210_abnormal_sex_determination0.73121084
170MP0009379_abnormal_foot_pigmentation0.72848422
171MP0000733_abnormal_muscle_development0.72832681
172MP0005379_endocrine/exocrine_gland_phen0.72815392
173MP0000747_muscle_weakness0.72370871
174MP0003935_abnormal_craniofacial_develop0.72258463
175MP0003075_altered_response_to0.72112743
176MP0002090_abnormal_vision0.72036589
177MP0000631_abnormal_neuroendocrine_gland0.71619202
178MP0006072_abnormal_retinal_apoptosis0.71443795
179MP0000003_abnormal_adipose_tissue0.70636092
180MP0000490_abnormal_crypts_of0.69219919
181MP0008961_abnormal_basal_metabolism0.69063069
182MP0001216_abnormal_epidermal_layer0.69041020
183MP0001145_abnormal_male_reproductive0.68778193
184MP0001340_abnormal_eyelid_morphology0.68718056
185MP0000703_abnormal_thymus_morphology0.68577965
186MP0002163_abnormal_gland_morphology0.67168800
187MP0001986_abnormal_taste_sensitivity0.66931234
188MP0005390_skeleton_phenotype0.66746949
189MP0003880_abnormal_central_pattern0.66497865
190MP0005397_hematopoietic_system_phenotyp0.66257808
191MP0009053_abnormal_anal_canal0.64662558
192MP0001177_atelectasis0.63610754

Predicted human phenotypes

RankGene SetZ-score
1Cortical dysplasia (HP:0002539)4.83000844
2Abnormality of glycosphingolipid metabolism (HP:0004343)4.73068907
3Abnormality of glycolipid metabolism (HP:0010969)4.73068907
4Abnormality of liposaccharide metabolism (HP:0010968)4.73068907
5Increased cerebral lipofuscin (HP:0011813)4.56032484
6Dysostosis multiplex (HP:0000943)4.37960134
7Hepatoblastoma (HP:0002884)4.32206280
8Increased neuronal autofluorescent lipopigment (HP:0002074)4.07978861
9Eczematoid dermatitis (HP:0000976)3.96725724
10Diminished motivation (HP:0000745)3.90018353
11Spastic diplegia (HP:0001264)3.73037202
12Apathy (HP:0000741)3.62368082
13Abnormality of the labia minora (HP:0012880)3.62197074
14Recurrent abscess formation (HP:0002722)3.58603155
15Disinhibition (HP:0000734)3.56537334
16Supranuclear gaze palsy (HP:0000605)3.55771088
17Vacuolated lymphocytes (HP:0001922)3.54040207
18Septo-optic dysplasia (HP:0100842)3.52046807
19Mucopolysacchariduria (HP:0008155)3.43742952
20Urinary glycosaminoglycan excretion (HP:0003541)3.43742952
21Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.43269739
22Recurrent bacterial skin infections (HP:0005406)3.37507366
23Segmental peripheral demyelination/remyelination (HP:0003481)3.37351229
24Abnormality of macrophages (HP:0004311)3.34217613
25Colon cancer (HP:0003003)3.28459562
26Abnormality of mucopolysaccharide metabolism (HP:0011020)3.06987338
27Abnormality of polysaccharide metabolism (HP:0011012)3.06987338
28Abnormality of glycosaminoglycan metabolism (HP:0004371)3.06987338
29Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.88347663
30Neurofibrillary tangles (HP:0002185)2.83918303
31Nephroblastoma (Wilms tumor) (HP:0002667)2.82841134
32Interstitial pulmonary disease (HP:0006530)2.81559402
33Choanal stenosis (HP:0000452)2.75080568
34Chronic obstructive pulmonary disease (HP:0006510)2.72484163
35Obstructive lung disease (HP:0006536)2.72484163
36Abnormal lung lobation (HP:0002101)2.72278854
37Hyperglycinemia (HP:0002154)2.67912292
38Recurrent gram-negative bacterial infections (HP:0005420)2.66442233
39Progressive neurologic deterioration (HP:0002344)2.66290667
40Restlessness (HP:0000711)2.66228750
41Bilateral microphthalmos (HP:0007633)2.65899144
42Multiple enchondromatosis (HP:0005701)2.65080284
43Thoracolumbar scoliosis (HP:0002944)2.58734212
44Embryonal renal neoplasm (HP:0011794)2.56173392
45Global brain atrophy (HP:0002283)2.55888398
46Nuclear cataract (HP:0100018)2.51724576
47Axonal loss (HP:0003447)2.51162750
48Medulloblastoma (HP:0002885)2.49016921
49Humeroradial synostosis (HP:0003041)2.43305868
50Synostosis involving the elbow (HP:0003938)2.43305868
51Personality changes (HP:0000751)2.40845602
52Maternal diabetes (HP:0009800)2.40065133
53Small epiphyses (HP:0010585)2.39656272
54Pelvic girdle muscle weakness (HP:0003749)2.38883079
55Abnormality of the septum pellucidum (HP:0007375)2.36709076
56Abnormal number of incisors (HP:0011064)2.36532778
57Reticulocytopenia (HP:0001896)2.33647226
58Hypercortisolism (HP:0001578)2.32653110
59Recurrent fungal infections (HP:0002841)2.32516915
60Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.32355782
61Peripheral hypomyelination (HP:0007182)2.31889843
62Chronic otitis media (HP:0000389)2.29870389
63Abnormality of the hip-girdle musculature (HP:0001445)2.28959129
64Abnormality of the musculature of the pelvis (HP:0001469)2.28959129
65Nasal polyposis (HP:0100582)2.27022737
66Cerebral inclusion bodies (HP:0100314)2.26853663
67Agitation (HP:0000713)2.26420045
68Hyperparathyroidism (HP:0000843)2.25799281
69Trigonocephaly (HP:0000243)2.25181372
70Clumsiness (HP:0002312)2.24925836
71Split foot (HP:0001839)2.23831472
72Mutism (HP:0002300)2.23786087
73Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.23284322
74Loss of speech (HP:0002371)2.21207537
75Hand muscle atrophy (HP:0009130)2.20704071
76Selective tooth agenesis (HP:0001592)2.20091967
77Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.19608848
78Myelomeningocele (HP:0002475)2.19302152
79Malignant gastrointestinal tract tumors (HP:0006749)2.18948907
80Gastrointestinal carcinoma (HP:0002672)2.18948907
81Mediastinal lymphadenopathy (HP:0100721)2.18591703
82Hemivertebrae (HP:0002937)2.17921471
83Cellulitis (HP:0100658)2.17066285
84Esophageal atresia (HP:0002032)2.16629779
85Dysautonomia (HP:0002459)2.16481966
86Hypoglycemic seizures (HP:0002173)2.15805049
87Homocystinuria (HP:0002156)2.14696784
88Abnormality of homocysteine metabolism (HP:0010919)2.14696784
89J-shaped sella turcica (HP:0002680)2.14309685
90Aplasia/Hypoplasia of the sternum (HP:0006714)2.14191001
91Horseshoe kidney (HP:0000085)2.14084828
92Poor head control (HP:0002421)2.14053642
93Recurrent viral infections (HP:0004429)2.13957505
94Absent septum pellucidum (HP:0001331)2.13704587
95Peripheral demyelination (HP:0011096)2.12730971
96Stenosis of the external auditory canal (HP:0000402)2.12226025
97Generalized hypotonia (HP:0001290)2.10635749
98Microvesicular hepatic steatosis (HP:0001414)2.10227839
99Elevated erythrocyte sedimentation rate (HP:0003565)2.08281672
100Stomatitis (HP:0010280)2.07624603
101High anterior hairline (HP:0009890)2.07568649
102Absent eyebrow (HP:0002223)2.06920899
103Absent forearm bone (HP:0003953)2.05677484
104Aplasia involving forearm bones (HP:0009822)2.05677484
105Partial duplication of thumb phalanx (HP:0009944)2.05640062
106Carpal bone hypoplasia (HP:0001498)2.03701363
107Distal upper limb amyotrophy (HP:0007149)2.02850236
108Upper limb amyotrophy (HP:0009129)2.02850236
109Vertebral compression fractures (HP:0002953)2.02837757
110Vaginal fistula (HP:0004320)2.01051816
111Macrocytic anemia (HP:0001972)2.00614536
112Recurrent skin infections (HP:0001581)2.00411853
113Facial cleft (HP:0002006)2.00199806
114Neuronal loss in central nervous system (HP:0002529)2.00011326
115Abnormal hair whorl (HP:0010721)1.99233773
116Vasculitis (HP:0002633)1.98298993
117Chronic sinusitis (HP:0011109)1.97342808
118Meckel diverticulum (HP:0002245)1.94825813
119Akinesia (HP:0002304)1.94478893
120Shoulder girdle muscle weakness (HP:0003547)1.94322766
121Birth length less than 3rd percentile (HP:0003561)1.93330622
122Hypoplastic pelvis (HP:0008839)1.93255855
123Broad alveolar ridges (HP:0000187)1.92929720
124Increased nuchal translucency (HP:0010880)1.92889588
125Anophthalmia (HP:0000528)1.90939068
126Chronic bronchitis (HP:0004469)1.90822406
127Broad thumb (HP:0011304)1.90798570
128Absent radius (HP:0003974)1.89732280
129Ulnar claw (HP:0001178)1.89446943
130Bronchitis (HP:0012387)1.89128498
131Recurrent bronchitis (HP:0002837)1.87999226
132Rectal fistula (HP:0100590)1.87960355
133Rectovaginal fistula (HP:0000143)1.87960355
134Breast aplasia (HP:0100783)1.87593657
135Eosinophilia (HP:0001880)1.86991717
136Hypogonadotrophic hypogonadism (HP:0000044)1.86005821
137Broad foot (HP:0001769)1.85953310
138Leiomyosarcoma (HP:0100243)1.85225586
139Uterine leiomyosarcoma (HP:0002891)1.85225586
140Progressive external ophthalmoplegia (HP:0000590)1.82488051
141Gastrointestinal stroma tumor (HP:0100723)1.81473448
142Uterine neoplasm (HP:0010784)1.80311029
143Increased hepatocellular lipid droplets (HP:0006565)1.80043503
144Abdominal situs inversus (HP:0003363)1.79132364
145Abnormality of abdominal situs (HP:0011620)1.79132364
146Hepatosplenomegaly (HP:0001433)1.78943961
147Increased IgE level (HP:0003212)1.78636384
148Bifid tongue (HP:0010297)1.78030531
149Neoplasm of the colon (HP:0100273)1.77808379
150Cellular immunodeficiency (HP:0005374)1.77608494
151Myopathic facies (HP:0002058)1.76941703
152Skull defect (HP:0001362)1.76490954
153Irregular vertebral endplates (HP:0003301)1.76376131
154Aplasia/Hypoplasia of the breasts (HP:0010311)1.75899165
155Duplication of thumb phalanx (HP:0009942)1.75889204
156Scrotal hypoplasia (HP:0000046)1.75638802
157Hypergammaglobulinemia (HP:0010702)1.75572523
158Abnormality of cells of the erythroid lineage (HP:0012130)1.75257423
159Pancreatic islet-cell hyperplasia (HP:0004510)1.74501262
160Restrictive lung disease (HP:0002091)1.74341770
161Transitional cell carcinoma of the bladder (HP:0006740)1.74036889
162Abnormality of the ileum (HP:0001549)1.73901115
163Gastrointestinal atresia (HP:0002589)1.73645375
164Omphalocele (HP:0001539)1.73382953
165Episodic fever (HP:0001954)1.73146744
166Abnormality of the distal phalanges of the toes (HP:0010182)1.72958789
167Flattened epiphyses (HP:0003071)1.72931217
168Pustule (HP:0200039)1.72746351
169Biliary tract neoplasm (HP:0100574)1.72611542
170Osteolytic defects of the phalanges of the hand (HP:0009771)1.72474192
171Osteolytic defects of the hand bones (HP:0009699)1.72474192
172Neuroblastic tumors (HP:0004376)1.72399755
173Peripheral primitive neuroectodermal neoplasm (HP:0030067)1.72399755
174Neuroblastoma (HP:0003006)1.72399755
175Primitive neuroectodermal tumor (HP:0030065)1.72399755
176Basal ganglia calcification (HP:0002135)1.71550631
177Agnosia (HP:0010524)1.71172592
178Rapidly progressive (HP:0003678)1.70869227
179Tetraparesis (HP:0002273)1.70436254
180Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.70391803
181Impulsivity (HP:0100710)1.70217216
182Embryonal neoplasm (HP:0002898)1.70179902
183Inappropriate behavior (HP:0000719)1.70085219
184Myositis (HP:0100614)1.69591754
185Postnatal microcephaly (HP:0005484)1.69355074
186Intestinal atresia (HP:0011100)1.67803229
187Increased CSF protein (HP:0002922)1.67468696
188Progressive muscle weakness (HP:0003323)1.65824077
189Partial agenesis of the corpus callosum (HP:0001338)1.65074134
190Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.65054760
191Onion bulb formation (HP:0003383)1.60134158
192Verrucae (HP:0200043)1.59468547
193Papilloma (HP:0012740)1.59468547
194Neurodegeneration (HP:0002180)1.58855896

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SRPK13.89528314
2CDC73.70941049
3SCYL22.91420881
4ARAF2.77689143
5TTK2.75036616
6KSR22.67434225
7RIPK42.66588622
8MKNK12.66053870
9TSSK62.57236043
10TESK12.53586380
11MAP3K92.51897617
12LIMK12.48950039
13EPHB12.33717244
14CDK122.22437413
15ERBB32.21715921
16MKNK22.12546984
17TESK22.08757707
18DYRK32.04890900
19BRD41.96535203
20TRIB31.95596827
21MAP3K21.79475436
22STK241.76466354
23PLK31.74565962
24BLK1.72781277
25TBK11.69097381
26TNIK1.64042157
27LATS21.61735696
28PIM21.58770168
29MAPK151.56523590
30ERN11.55474888
31TYK21.54511542
32MAP3K111.51591442
33TAF11.49765550
34EPHA21.48686072
35MAP4K11.47701094
36RPS6KA41.47386806
37NTRK11.46056674
38MAP3K131.44337774
39BUB11.40819650
40MAP3K41.39482883
41MARK31.38437136
42TRIM281.36791504
43CSNK1G11.35232083
44PAK61.30040120
45MAP2K71.29646854
46MOS1.29243465
47PAK31.28470879
48KSR11.28408879
49STK38L1.27999375
50IRAK11.22393632
51PLK11.21327742
52WEE11.21117474
53TYRO31.20531839
54JAK31.19535849
55VRK21.18370119
56MAP3K11.18263411
57NEK11.18119206
58ZAP701.17280772
59CHEK21.15288426
60HIPK21.14845453
61MST41.14765415
62NME21.13082845
63LATS11.12896318
64LRRK21.12211412
65RAF11.10435838
66EIF2AK31.10347712
67PLK41.09344849
68PBK1.07519924
69CAMKK21.05284167
70MAP3K31.04410108
71FES1.03865790
72DYRK21.03587514
73MAPKAPK31.02660084
74FGFR40.99068139
75CSK0.97848850
76FGFR10.95544094
77ZAK0.95367537
78ITK0.95130985
79BRSK20.93396798
80CDK60.92744849
81MAP3K100.91286887
82SYK0.90270025
83IRAK40.89541457
84NEK20.89145058
85STK160.89122555
86HCK0.88270740
87ATR0.87262055
88EPHA30.86794659
89WNK30.86480213
90CSNK1A1L0.86047051
91DYRK1B0.85505502
92CDK40.85286335
93CHEK10.82805611
94UHMK10.82319159
95ALK0.81807164
96CSNK1G30.81233408
97MAP2K20.80639312
98SMG10.79608613
99MAP3K50.78264431
100PAK40.76664660
101LMTK20.76278805
102CDK11A0.76030427
103CDK70.75952476
104PNCK0.75164807
105MAP2K10.75095964
106CSNK1E0.74450094
107ATM0.73970046
108PKN20.73689929
109DYRK1A0.71701214
110CDK180.71557351
111STK100.71493873
112CDK140.70273833
113CDK150.70019993
114JAK10.69657692
115IRAK20.69025017
116EGFR0.68777875
117BMX0.68308984
118YES10.68257054
119CSNK1G20.67489709
120ACVR1B0.67214317
121JAK20.67005072
122NLK0.66232166
123GRK60.65471042
124FGR0.65396592
125ERBB40.65112313
126CDK20.64955913
127PTK20.64894594
128MAP3K80.64725390
129CLK10.63437814
130VRK10.63061440
131AURKB0.62150282
132AURKA0.61676993
133PDPK10.61353347
134MINK10.58642069
135PIM10.58024887
136CDK10.57968784
137DMPK0.57487145
138PASK0.57398071
139STK40.57328857
140NEK90.57272849
141BCR0.56241639
142EIF2AK10.55764631
143PAK10.55474350
144CAMK1G0.55335758
145TAOK10.53831112
146MAP3K140.53712004
147CDK190.52248987
148LCK0.52165862
149BRSK10.51862606
150ABL20.50624495
151PIK3CG0.50434094
152RPS6KA50.49795832
153PDK10.49425578
154CAMK1D0.48816364
155MAPKAPK20.48680953
156MAP3K120.48520153
157NME10.48467484
158STK30.47999482
159BRAF0.47713137
160EEF2K0.45545663
161CSNK2A20.45245559
162CSNK2A10.44456769
163IKBKB0.43652229
164STK390.43183382
165PRKDC0.43038804
166RPS6KA10.42953864
167MATK0.40151522

Predicted pathways (KEGG)

RankGene SetZ-score
1Spliceosome_Homo sapiens_hsa030403.76494538
2DNA replication_Homo sapiens_hsa030303.39726770
3Mismatch repair_Homo sapiens_hsa034303.09618476
4Ribosome_Homo sapiens_hsa030102.87481073
5Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.86843842
6RNA transport_Homo sapiens_hsa030132.79597876
7mRNA surveillance pathway_Homo sapiens_hsa030152.77610653
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.61970299
9Lysosome_Homo sapiens_hsa041422.49684525
10RNA polymerase_Homo sapiens_hsa030202.38409033
11Base excision repair_Homo sapiens_hsa034102.37975186
12Steroid biosynthesis_Homo sapiens_hsa001002.32968471
13Cell cycle_Homo sapiens_hsa041102.32661664
14Non-homologous end-joining_Homo sapiens_hsa034502.24198686
15Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.21440217
16Selenocompound metabolism_Homo sapiens_hsa004501.98842634
17Vibrio cholerae infection_Homo sapiens_hsa051101.98624299
18Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.97607533
19Basal transcription factors_Homo sapiens_hsa030221.97304169
20Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.92184713
21Leishmaniasis_Homo sapiens_hsa051401.89839553
22Cysteine and methionine metabolism_Homo sapiens_hsa002701.87819274
23Shigellosis_Homo sapiens_hsa051311.82671863
24RNA degradation_Homo sapiens_hsa030181.79762345
25Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.77083239
26B cell receptor signaling pathway_Homo sapiens_hsa046621.76745859
27Osteoclast differentiation_Homo sapiens_hsa043801.75520546
28Nucleotide excision repair_Homo sapiens_hsa034201.71397770
29Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.69463640
30Phagosome_Homo sapiens_hsa041451.68067208
31One carbon pool by folate_Homo sapiens_hsa006701.66042512
32Biosynthesis of amino acids_Homo sapiens_hsa012301.63739735
33Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.62018750
34Renal cell carcinoma_Homo sapiens_hsa052111.57329639
35Legionellosis_Homo sapiens_hsa051341.53689155
36Glycosaminoglycan degradation_Homo sapiens_hsa005311.49758631
37Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.49315856
38Tuberculosis_Homo sapiens_hsa051521.48188022
39Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.47372701
40Regulation of autophagy_Homo sapiens_hsa041401.44710067
41Rheumatoid arthritis_Homo sapiens_hsa053231.40597860
42Endocytosis_Homo sapiens_hsa041441.39568426
43T cell receptor signaling pathway_Homo sapiens_hsa046601.38977842
44Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.38385582
45Thyroid cancer_Homo sapiens_hsa052161.38197831
46NOD-like receptor signaling pathway_Homo sapiens_hsa046211.37254819
47Protein export_Homo sapiens_hsa030601.37193469
48Basal cell carcinoma_Homo sapiens_hsa052171.37007495
49Neurotrophin signaling pathway_Homo sapiens_hsa047221.36735332
50Salmonella infection_Homo sapiens_hsa051321.36636937
51Antigen processing and presentation_Homo sapiens_hsa046121.36509764
52Dorso-ventral axis formation_Homo sapiens_hsa043201.34612676
53Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.31766456
54Collecting duct acid secretion_Homo sapiens_hsa049661.30570580
55Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.28927051
56Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.28045738
57Pyrimidine metabolism_Homo sapiens_hsa002401.27605478
58Hippo signaling pathway_Homo sapiens_hsa043901.27056714
59Pertussis_Homo sapiens_hsa051331.26891418
60Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.24212444
61Chronic myeloid leukemia_Homo sapiens_hsa052201.23853930
62VEGF signaling pathway_Homo sapiens_hsa043701.23558078
63Toll-like receptor signaling pathway_Homo sapiens_hsa046201.21695188
64Parkinsons disease_Homo sapiens_hsa050121.19288868
65Adherens junction_Homo sapiens_hsa045201.18876010
66Graft-versus-host disease_Homo sapiens_hsa053321.18809279
67Huntingtons disease_Homo sapiens_hsa050161.18352525
68Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.17206061
69Maturity onset diabetes of the young_Homo sapiens_hsa049501.16970106
70Wnt signaling pathway_Homo sapiens_hsa043101.16497850
71Sphingolipid metabolism_Homo sapiens_hsa006001.14730027
72Prion diseases_Homo sapiens_hsa050201.13880739
73Sphingolipid signaling pathway_Homo sapiens_hsa040711.13420340
74TNF signaling pathway_Homo sapiens_hsa046681.13196882
75Proteasome_Homo sapiens_hsa030501.12706753
76Other glycan degradation_Homo sapiens_hsa005111.12524985
77Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.08968006
78Toxoplasmosis_Homo sapiens_hsa051451.08341836
79Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.07889868
80Apoptosis_Homo sapiens_hsa042101.07525298
81Type I diabetes mellitus_Homo sapiens_hsa049401.07136267
82Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.04732508
83Homologous recombination_Homo sapiens_hsa034401.04482480
84Acute myeloid leukemia_Homo sapiens_hsa052211.03815661
85Chemokine signaling pathway_Homo sapiens_hsa040621.03353026
86NF-kappa B signaling pathway_Homo sapiens_hsa040641.02624716
87Leukocyte transendothelial migration_Homo sapiens_hsa046701.02049472
88Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.01536939
89Hepatitis B_Homo sapiens_hsa051611.01530126
90Folate biosynthesis_Homo sapiens_hsa007901.01131539
91Oxidative phosphorylation_Homo sapiens_hsa001901.00320902
92Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.97296721
93p53 signaling pathway_Homo sapiens_hsa041150.96777513
94Central carbon metabolism in cancer_Homo sapiens_hsa052300.96366149
95Pancreatic cancer_Homo sapiens_hsa052120.96246626
96Fanconi anemia pathway_Homo sapiens_hsa034600.95625667
97Hedgehog signaling pathway_Homo sapiens_hsa043400.95563744
98Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.95147350
99Epstein-Barr virus infection_Homo sapiens_hsa051690.94071446
1002-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.93527140
101Carbon metabolism_Homo sapiens_hsa012000.93374064
102Prolactin signaling pathway_Homo sapiens_hsa049170.90848292
103Viral myocarditis_Homo sapiens_hsa054160.88773854
104Measles_Homo sapiens_hsa051620.87670016
105Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.83777757
106Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.82580317
107Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.82432056
108Purine metabolism_Homo sapiens_hsa002300.81735977
109Tight junction_Homo sapiens_hsa045300.80786218
110MicroRNAs in cancer_Homo sapiens_hsa052060.79551881
111Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.78396340
112Amoebiasis_Homo sapiens_hsa051460.77788933
113Carbohydrate digestion and absorption_Homo sapiens_hsa049730.77406615
114Viral carcinogenesis_Homo sapiens_hsa052030.76532370
115AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.76212362
116mTOR signaling pathway_Homo sapiens_hsa041500.75729839
117Hematopoietic cell lineage_Homo sapiens_hsa046400.75457207
118Primary immunodeficiency_Homo sapiens_hsa053400.74946400
119Malaria_Homo sapiens_hsa051440.74734227
120Axon guidance_Homo sapiens_hsa043600.74375384
121Pyruvate metabolism_Homo sapiens_hsa006200.74174710
122Estrogen signaling pathway_Homo sapiens_hsa049150.73326043
123Colorectal cancer_Homo sapiens_hsa052100.72192748
124Type II diabetes mellitus_Homo sapiens_hsa049300.71561637
125Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.71373883
126Phospholipase D signaling pathway_Homo sapiens_hsa040720.70595277
127Allograft rejection_Homo sapiens_hsa053300.70462938
128Synaptic vesicle cycle_Homo sapiens_hsa047210.70348453
129Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.70236134
130Glioma_Homo sapiens_hsa052140.69747851
131Asthma_Homo sapiens_hsa053100.69390972
132Jak-STAT signaling pathway_Homo sapiens_hsa046300.68892482
133Intestinal immune network for IgA production_Homo sapiens_hsa046720.67142950
134Phosphatidylinositol signaling system_Homo sapiens_hsa040700.67074640
135Influenza A_Homo sapiens_hsa051640.67006949
136SNARE interactions in vesicular transport_Homo sapiens_hsa041300.66179688
137ErbB signaling pathway_Homo sapiens_hsa040120.66104838
138TGF-beta signaling pathway_Homo sapiens_hsa043500.65860968
139FoxO signaling pathway_Homo sapiens_hsa040680.63839588
140Proteoglycans in cancer_Homo sapiens_hsa052050.63776974
141Adipocytokine signaling pathway_Homo sapiens_hsa049200.62910630
142Choline metabolism in cancer_Homo sapiens_hsa052310.58704036
143Fatty acid elongation_Homo sapiens_hsa000620.58378330
144Hepatitis C_Homo sapiens_hsa051600.57379150
145Glycerophospholipid metabolism_Homo sapiens_hsa005640.57107823
146Inositol phosphate metabolism_Homo sapiens_hsa005620.55389980
147Endometrial cancer_Homo sapiens_hsa052130.54077704
148Platelet activation_Homo sapiens_hsa046110.53805039
149RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.53472949
150Prostate cancer_Homo sapiens_hsa052150.52730214
151Insulin resistance_Homo sapiens_hsa049310.52693423
152Sulfur relay system_Homo sapiens_hsa041220.51294143
153MAPK signaling pathway_Homo sapiens_hsa040100.49792784
154Oocyte meiosis_Homo sapiens_hsa041140.49386466
155Cardiac muscle contraction_Homo sapiens_hsa042600.48899798
156Ether lipid metabolism_Homo sapiens_hsa005650.48442411
157Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.47540211
158Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.47302025
159Arginine and proline metabolism_Homo sapiens_hsa003300.46794397
160Bladder cancer_Homo sapiens_hsa052190.43521984
161Alzheimers disease_Homo sapiens_hsa050100.38957811
162Notch signaling pathway_Homo sapiens_hsa043300.38633095
163Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.35622951
164Pathways in cancer_Homo sapiens_hsa052000.34168957
165Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.29859588
166Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.29335881
167Metabolic pathways_Homo sapiens_hsa011000.28025529
168Alcoholism_Homo sapiens_hsa050340.26952527
169Propanoate metabolism_Homo sapiens_hsa006400.26800550
170Melanogenesis_Homo sapiens_hsa049160.26728718
171Gap junction_Homo sapiens_hsa045400.25938321
172Nicotine addiction_Homo sapiens_hsa050330.24710733
173Galactose metabolism_Homo sapiens_hsa000520.23582221
174Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.19997709
175Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.19250335
176HTLV-I infection_Homo sapiens_hsa051660.18942645
177Vitamin B6 metabolism_Homo sapiens_hsa007500.18767820
178Rap1 signaling pathway_Homo sapiens_hsa040150.17578837
179Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.17208530
180AMPK signaling pathway_Homo sapiens_hsa041520.16740456

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