AKIP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a nuclear protein that interacts with protein kinase A catalytic subunit, and regulates the effect of the cAMP-dependent protein kinase signaling pathway on the NF-kappa-B activation cascade. Alternatively spliced transcript variants have been described for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)5.69738744
2DNA deamination (GO:0045006)5.50318049
3protein complex biogenesis (GO:0070271)4.86080659
4telomere maintenance via semi-conservative replication (GO:0032201)4.80484683
5DNA strand elongation involved in DNA replication (GO:0006271)4.63540272
6mitochondrial respiratory chain complex I assembly (GO:0032981)4.57208441
7NADH dehydrogenase complex assembly (GO:0010257)4.57208441
8mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.57208441
9mitochondrial respiratory chain complex assembly (GO:0033108)4.52872644
10DNA strand elongation (GO:0022616)4.43325177
11viral transcription (GO:0019083)4.34603102
12respiratory chain complex IV assembly (GO:0008535)4.31438921
13establishment of protein localization to mitochondrial membrane (GO:0090151)4.28891652
14telomere maintenance via recombination (GO:0000722)4.27979936
15translational termination (GO:0006415)4.26231620
16maturation of SSU-rRNA (GO:0030490)4.24689525
17platelet dense granule organization (GO:0060155)4.17412175
18mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.06178206
19ribosomal small subunit biogenesis (GO:0042274)4.03011620
20cytochrome complex assembly (GO:0017004)3.99790117
21deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.97178662
22protein neddylation (GO:0045116)3.95516535
23SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.93323456
24mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.93227355
25cullin deneddylation (GO:0010388)3.89012086
26mitotic recombination (GO:0006312)3.86756657
27DNA replication checkpoint (GO:0000076)3.86470412
28DNA replication initiation (GO:0006270)3.86045014
29translational elongation (GO:0006414)3.85250593
30ATP synthesis coupled proton transport (GO:0015986)3.83260382
31energy coupled proton transport, down electrochemical gradient (GO:0015985)3.83260382
32protein deneddylation (GO:0000338)3.83121670
33cotranslational protein targeting to membrane (GO:0006613)3.82840183
34chaperone-mediated protein transport (GO:0072321)3.80840133
35protein targeting to ER (GO:0045047)3.80834231
36behavioral response to nicotine (GO:0035095)3.80716659
37telomere maintenance via telomere lengthening (GO:0010833)3.78033329
38proteasome assembly (GO:0043248)3.72032884
39formation of translation preinitiation complex (GO:0001731)3.69877335
40negative regulation of telomere maintenance (GO:0032205)3.67313765
41protein localization to endoplasmic reticulum (GO:0070972)3.67266912
42water-soluble vitamin biosynthetic process (GO:0042364)3.61631439
43positive regulation of mitochondrial fission (GO:0090141)3.58738462
44establishment of protein localization to endoplasmic reticulum (GO:0072599)3.58726242
45L-fucose catabolic process (GO:0042355)3.56464339
46fucose catabolic process (GO:0019317)3.56464339
47L-fucose metabolic process (GO:0042354)3.56464339
48ribosomal large subunit biogenesis (GO:0042273)3.55440879
49tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.54769079
50RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.54769079
51nucleotide-excision repair, DNA gap filling (GO:0006297)3.49781316
52CENP-A containing nucleosome assembly (GO:0034080)3.49490090
53translational initiation (GO:0006413)3.48855408
54mannosylation (GO:0097502)3.48061099
55electron transport chain (GO:0022900)3.47607833
56chromatin remodeling at centromere (GO:0031055)3.47360595
57respiratory electron transport chain (GO:0022904)3.42495149
58maturation of 5.8S rRNA (GO:0000460)3.40042018
59protein-cofactor linkage (GO:0018065)3.35047640
60pseudouridine synthesis (GO:0001522)3.34276916
61viral life cycle (GO:0019058)3.34067813
62ubiquinone biosynthetic process (GO:0006744)3.33923518
63nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.27571015
64nucleobase biosynthetic process (GO:0046112)3.25097803
65ribonucleoprotein complex biogenesis (GO:0022613)3.24421358
66cellular protein complex disassembly (GO:0043624)3.21414678
67ubiquinone metabolic process (GO:0006743)3.20270508
68purine nucleobase biosynthetic process (GO:0009113)3.19195859
69translation (GO:0006412)3.15058075
70cytidine metabolic process (GO:0046087)3.12240608
71cytidine catabolic process (GO:0006216)3.12240608
72cytidine deamination (GO:0009972)3.12240608
73regulation of mitochondrial translation (GO:0070129)3.09632000
74exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.04512658
75negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.02469477
76regulation of cilium movement (GO:0003352)3.01067240
77preassembly of GPI anchor in ER membrane (GO:0016254)3.01054234
78folic acid metabolic process (GO:0046655)2.98336597
79protein polyglutamylation (GO:0018095)2.95605255
80amino acid salvage (GO:0043102)2.95493762
81L-methionine salvage (GO:0071267)2.95493762
82L-methionine biosynthetic process (GO:0071265)2.95493762
83rRNA processing (GO:0006364)2.95407933
84peptidyl-histidine modification (GO:0018202)2.95114218
85deoxyribonucleotide biosynthetic process (GO:0009263)2.94697299
86antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.94409410
87dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.90493626
88DNA replication-independent nucleosome assembly (GO:0006336)2.90406657
89DNA replication-independent nucleosome organization (GO:0034724)2.90406657
90pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.89847128
91DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.89629059
92cellular ketone body metabolic process (GO:0046950)2.88821203
93tRNA processing (GO:0008033)2.88620506
94ribosome assembly (GO:0042255)2.88527629
95nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.88388193
96ribosome biogenesis (GO:0042254)2.88293195
97response to pheromone (GO:0019236)2.86608268
98intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.85840419
99signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.85840419
100rRNA metabolic process (GO:0016072)2.85058801
101regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.85027932
102signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.84889118
103signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.84889118
104signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.84889118
105regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.84232154
106DNA unwinding involved in DNA replication (GO:0006268)2.83423212
107regulation of cellular amino acid metabolic process (GO:0006521)2.83357036
108DNA double-strand break processing (GO:0000729)2.83043730
109antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.83015019
110deoxyribose phosphate biosynthetic process (GO:0046385)2.82890654
1112-deoxyribonucleotide biosynthetic process (GO:0009265)2.82890654
112base-excision repair, AP site formation (GO:0006285)2.81468544
113pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.81284502
114protein targeting to mitochondrion (GO:0006626)2.80577938
115telomere organization (GO:0032200)2.80334494
116transcription-coupled nucleotide-excision repair (GO:0006283)2.80132691
117establishment of protein localization to mitochondrion (GO:0072655)2.80121454
118positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.78524344
119telomere maintenance (GO:0000723)2.77980446
120metallo-sulfur cluster assembly (GO:0031163)2.77912811
121iron-sulfur cluster assembly (GO:0016226)2.77912811
122protein complex disassembly (GO:0043241)2.77769542
123termination of RNA polymerase III transcription (GO:0006386)2.77699037
124transcription elongation from RNA polymerase III promoter (GO:0006385)2.77699037
125hydrogen ion transmembrane transport (GO:1902600)2.77600612
126anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.77331747
127C-terminal protein lipidation (GO:0006501)2.76164114
128nonmotile primary cilium assembly (GO:0035058)2.75068919
129signal transduction involved in DNA integrity checkpoint (GO:0072401)2.74510984
130signal transduction involved in DNA damage checkpoint (GO:0072422)2.74510984
131GPI anchor metabolic process (GO:0006505)2.74100377
132nuclear-transcribed mRNA catabolic process (GO:0000956)2.72349907
133intracellular protein transmembrane import (GO:0044743)2.72329343
134negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.72025249
135negative regulation of ligase activity (GO:0051352)2.72025249
136C-terminal protein amino acid modification (GO:0018410)2.71016100
137folic acid-containing compound biosynthetic process (GO:0009396)2.70885383
138cellular component biogenesis (GO:0044085)2.70470933
139cell cycle G1/S phase transition (GO:0044843)2.70305598
140G1/S transition of mitotic cell cycle (GO:0000082)2.70305598
141protein K6-linked ubiquitination (GO:0085020)2.69923814
142viral mRNA export from host cell nucleus (GO:0046784)2.69170366
143spliceosomal snRNP assembly (GO:0000387)2.69001245
144signal transduction involved in cell cycle checkpoint (GO:0072395)2.68874329
145proton transport (GO:0015992)2.67794852
146L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.67345303
147nucleobase-containing small molecule interconversion (GO:0015949)2.66908429
148protein localization to mitochondrion (GO:0070585)2.66400838
149macromolecular complex disassembly (GO:0032984)2.66366920
150positive regulation of prostaglandin secretion (GO:0032308)2.65400486
151deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.65087426
152pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.64838909
153pyrimidine ribonucleoside catabolic process (GO:0046133)2.64334803
154histone exchange (GO:0043486)2.64072577
155deoxyribonucleotide catabolic process (GO:0009264)2.63257307
156kinetochore organization (GO:0051383)2.61477962
157hydrogen transport (GO:0006818)2.61220463
158rRNA modification (GO:0000154)2.60377458
159replication fork processing (GO:0031297)2.59963239
160anterograde synaptic vesicle transport (GO:0048490)2.59535371
161ketone body metabolic process (GO:1902224)2.59188921
162mRNA catabolic process (GO:0006402)2.59009711
163regulation of mitochondrial fission (GO:0090140)2.58874319
164inner mitochondrial membrane organization (GO:0007007)2.58183824
165piRNA metabolic process (GO:0034587)2.56128787
166tRNA methylation (GO:0030488)2.55559602
167pteridine-containing compound biosynthetic process (GO:0042559)2.55163192
168kinetochore assembly (GO:0051382)2.53064963
169RNA catabolic process (GO:0006401)2.52924254
170response to interferon-beta (GO:0035456)2.51948204
171branched-chain amino acid catabolic process (GO:0009083)2.50483062
172positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.47236444

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.79976966
2MYC_18555785_ChIP-Seq_MESCs_Mouse3.74203257
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.71477945
4HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.50581649
5ZNF274_21170338_ChIP-Seq_K562_Hela3.43351431
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.35011706
7GABP_17652178_ChIP-ChIP_JURKAT_Human2.97641404
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.97131899
9EST1_17652178_ChIP-ChIP_JURKAT_Human2.92425868
10E2F4_17652178_ChIP-ChIP_JURKAT_Human2.79767073
11MYC_18358816_ChIP-ChIP_MESCs_Mouse2.71356671
12FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.70526513
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.66268021
14SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.61014476
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.52598041
16ELF1_17652178_ChIP-ChIP_JURKAT_Human2.51412661
17NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.47223985
18FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.46891313
19MYC_19030024_ChIP-ChIP_MESCs_Mouse2.44355512
20SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.31873700
21VDR_22108803_ChIP-Seq_LS180_Human2.29156030
22HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.26371404
23MYC_19079543_ChIP-ChIP_MESCs_Mouse2.25510136
24VDR_23849224_ChIP-Seq_CD4+_Human2.22956996
25GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.20743734
26XRN2_22483619_ChIP-Seq_HELA_Human2.09977167
27E2F1_18555785_ChIP-Seq_MESCs_Mouse2.05511701
28CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.04169065
29FOXM1_23109430_ChIP-Seq_U2OS_Human2.03448301
30IGF1R_20145208_ChIP-Seq_DFB_Human1.97217091
31NELFA_20434984_ChIP-Seq_ESCs_Mouse1.96313326
32SRF_21415370_ChIP-Seq_HL-1_Mouse1.96285417
33DCP1A_22483619_ChIP-Seq_HELA_Human1.94787532
34FOXP3_21729870_ChIP-Seq_TREG_Human1.94142440
35TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.93965228
36FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.92299199
37IRF8_22096565_ChIP-ChIP_GC-B_Human1.92229548
38HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.87004800
39EWS_26573619_Chip-Seq_HEK293_Human1.78683680
40GABP_19822575_ChIP-Seq_HepG2_Human1.77301859
41CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.76147709
42* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.70346931
43HOXB4_20404135_ChIP-ChIP_EML_Mouse1.70094990
44FLI1_27457419_Chip-Seq_LIVER_Mouse1.69662075
45ERG_20887958_ChIP-Seq_HPC-7_Mouse1.67611633
46EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.66165826
47ZFP57_27257070_Chip-Seq_ESCs_Mouse1.65387356
48IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.62022282
49IRF1_19129219_ChIP-ChIP_H3396_Human1.60786818
50MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.60213965
51SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.59695706
52SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.58553954
53TTF2_22483619_ChIP-Seq_HELA_Human1.58285447
54FUS_26573619_Chip-Seq_HEK293_Human1.57852857
55TP53_22573176_ChIP-Seq_HFKS_Human1.55442872
56AR_21909140_ChIP-Seq_LNCAP_Human1.53897112
57E2F1_21310950_ChIP-Seq_MCF-7_Human1.52645991
58PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.52140341
59ELK1_19687146_ChIP-ChIP_HELA_Human1.52028804
60E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.51809822
61NOTCH1_21737748_ChIP-Seq_TLL_Human1.50021225
62THAP11_20581084_ChIP-Seq_MESCs_Mouse1.49321583
63GBX2_23144817_ChIP-Seq_PC3_Human1.46530889
64CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.44950204
65CTBP2_25329375_ChIP-Seq_LNCAP_Human1.44353403
66MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.44245931
67CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.42368430
68YY1_21170310_ChIP-Seq_MESCs_Mouse1.42113263
69MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.41723145
70POU3F2_20337985_ChIP-ChIP_501MEL_Human1.39611908
71ZFX_18555785_ChIP-Seq_MESCs_Mouse1.38842556
72PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.38802882
73GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.37122102
74MYCN_18555785_ChIP-Seq_MESCs_Mouse1.37042962
75P300_19829295_ChIP-Seq_ESCs_Human1.35316251
76SPI1_23547873_ChIP-Seq_NB4_Human1.35085233
77ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.34374891
78NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.34081682
79MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.30922367
80CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.30011301
81RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.28013740
82POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.27151014
83NANOG_18555785_ChIP-Seq_MESCs_Mouse1.27149555
84EZH2_22144423_ChIP-Seq_EOC_Human1.25675372
85STAT3_1855785_ChIP-Seq_MESCs_Mouse1.25304398
86ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.25213767
87BP1_19119308_ChIP-ChIP_Hs578T_Human1.23169256
88PCGF2_27294783_Chip-Seq_ESCs_Mouse1.21350280
89IRF8_21731497_ChIP-ChIP_J774_Mouse1.20814541
90MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.20537798
91AR_20517297_ChIP-Seq_VCAP_Human1.18398655
92ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.17786984
93CTBP1_25329375_ChIP-Seq_LNCAP_Human1.17603487
94KDM5A_27292631_Chip-Seq_BREAST_Human1.17345239
95FOXA1_27270436_Chip-Seq_PROSTATE_Human1.15882777
96FOXA1_25329375_ChIP-Seq_VCAP_Human1.15882777
97CIITA_25753668_ChIP-Seq_RAJI_Human1.15426212
98NANOG_19829295_ChIP-Seq_ESCs_Human1.13734281
99SOX2_19829295_ChIP-Seq_ESCs_Human1.13734281
100POU5F1_16153702_ChIP-ChIP_HESCs_Human1.11604008
101PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.11403347
102MYC_22102868_ChIP-Seq_BL_Human1.11317865
103STAT4_19710469_ChIP-ChIP_TH1__Mouse1.09504968
104E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.09422095
105GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.08084292
106EGR1_23403033_ChIP-Seq_LIVER_Mouse1.07367800
107MYB_21317192_ChIP-Seq_ERMYB_Mouse1.02960417
108GATA1_22383799_ChIP-Seq_G1ME_Mouse1.02514851
109BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.02380838
110VDR_21846776_ChIP-Seq_THP-1_Human1.02003868
111TFEB_21752829_ChIP-Seq_HELA_Human1.01972577
112HTT_18923047_ChIP-ChIP_STHdh_Human1.00186913
113BMI1_23680149_ChIP-Seq_NPCS_Mouse1.00044729
114GATA3_21878914_ChIP-Seq_MCF-7_Human0.99893781
115HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.99106927
116SOX2_16153702_ChIP-ChIP_HESCs_Human0.99089236
117CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.98892151
118GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.98473633
119NCOR_22424771_ChIP-Seq_293T_Human0.97289558
120SCL_19346495_ChIP-Seq_HPC-7_Human0.96637534
121EGR1_19374776_ChIP-ChIP_THP-1_Human0.96203860
122GATA1_22025678_ChIP-Seq_K562_Human0.96140893
123PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.95257797
124KLF4_18555785_ChIP-Seq_MESCs_Mouse0.95044533
125MYC_18940864_ChIP-ChIP_HL60_Human0.94959559
126CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.93406260
127ETV2_25802403_ChIP-Seq_MESCs_Mouse0.93149439
128YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.93010142
129HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.92406424
130GATA2_22383799_ChIP-Seq_G1ME_Mouse0.92334187
131CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.91901485
132ER_23166858_ChIP-Seq_MCF-7_Human0.91748294
133CBP_20019798_ChIP-Seq_JUKART_Human0.90447657
134IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.90447657
135UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.89841591
136NANOG_16153702_ChIP-ChIP_HESCs_Human0.89831716
137POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.89363852
138TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.89190502
139ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.88832722
140PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.88182822
141HOXB7_26014856_ChIP-Seq_BT474_Human0.88117618
142MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.88059180
143FOXA1_21572438_ChIP-Seq_LNCaP_Human0.87871347
144FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.87418491
145PADI4_21655091_ChIP-ChIP_MCF-7_Human0.86438596
146ELK1_22589737_ChIP-Seq_MCF10A_Human0.86141113
147CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.85731312
148LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.84518438
149MYC_19829295_ChIP-Seq_ESCs_Human0.84174891
150NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.83839420
151KLF5_20875108_ChIP-Seq_MESCs_Mouse0.83210738
152TAF15_26573619_Chip-Seq_HEK293_Human0.81459268

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.05583598
2MP0002102_abnormal_ear_morphology3.51251241
3MP0010094_abnormal_chromosome_stability3.11933442
4MP0004957_abnormal_blastocyst_morpholog3.00946709
5MP0003806_abnormal_nucleotide_metabolis2.85400621
6MP0002396_abnormal_hematopoietic_system2.67460137
7MP0003111_abnormal_nucleus_morphology2.66413623
8MP0003186_abnormal_redox_activity2.58293921
9MP0002837_dystrophic_cardiac_calcinosis2.58019240
10MP0008058_abnormal_DNA_repair2.55705357
11MP0003077_abnormal_cell_cycle2.53024379
12MP0001835_abnormal_antigen_presentation2.46560967
13MP0008057_abnormal_DNA_replication2.42785337
14MP0005084_abnormal_gallbladder_morpholo2.35023756
15MP0002736_abnormal_nociception_after2.18031929
16MP0008007_abnormal_cellular_replicative2.16732689
17MP0001529_abnormal_vocalization2.14202263
18MP0002938_white_spotting2.08981895
19MP0000490_abnormal_crypts_of2.05664198
20MP0001968_abnormal_touch/_nociception2.03457875
21MP0006276_abnormal_autonomic_nervous2.01802895
22MP0003195_calcinosis1.99912404
23MP0002234_abnormal_pharynx_morphology1.99203830
24MP0000569_abnormal_digit_pigmentation1.98309161
25MP0004142_abnormal_muscle_tone1.96807505
26MP0006072_abnormal_retinal_apoptosis1.94961530
27MP0001853_heart_inflammation1.89542104
28MP0009785_altered_susceptibility_to1.87018976
29MP0002132_abnormal_respiratory_system1.84169692
30MP0001984_abnormal_olfaction1.83426794
31MP0009046_muscle_twitch1.83189576
32MP0002653_abnormal_ependyma_morphology1.80968740
33MP0004133_heterotaxia1.80034991
34MP0008872_abnormal_physiological_respon1.78979676
35MP0005551_abnormal_eye_electrophysiolog1.78759630
36MP0003656_abnormal_erythrocyte_physiolo1.78298198
37MP0003763_abnormal_thymus_physiology1.78286873
38MP0001905_abnormal_dopamine_level1.78209960
39MP0005397_hematopoietic_system_phenotyp1.76603651
40MP0001545_abnormal_hematopoietic_system1.76603651
41MP0005645_abnormal_hypothalamus_physiol1.72080735
42MP0008789_abnormal_olfactory_epithelium1.71664297
43MP0003880_abnormal_central_pattern1.69352139
44MP0002163_abnormal_gland_morphology1.69220868
45MP0009697_abnormal_copulation1.67589012
46MP0003136_yellow_coat_color1.62526802
47MP0003436_decreased_susceptibility_to1.61426577
48MP0005253_abnormal_eye_physiology1.60943057
49MP0009379_abnormal_foot_pigmentation1.60547929
50MP0000685_abnormal_immune_system1.60076958
51MP0002148_abnormal_hypersensitivity_rea1.59934432
52MP0009333_abnormal_splenocyte_physiolog1.59384352
53MP0005671_abnormal_response_to1.59366340
54MP0005025_abnormal_response_to1.57957335
55MP0009840_abnormal_foam_cell1.56943545
56MP0004147_increased_porphyrin_level1.56910593
57MP0002166_altered_tumor_susceptibility1.55433285
58MP0003718_maternal_effect1.54878539
59MP0006036_abnormal_mitochondrial_physio1.54640057
60MP0006054_spinal_hemorrhage1.53898381
61MP0002398_abnormal_bone_marrow1.52309748
62MP0002876_abnormal_thyroid_physiology1.51460435
63MP0004808_abnormal_hematopoietic_stem1.50996313
64MP0003786_premature_aging1.49135497
65MP0002138_abnormal_hepatobiliary_system1.46561753
66MP0000689_abnormal_spleen_morphology1.46144218
67MP0002006_tumorigenesis1.45309042
68MP0001800_abnormal_humoral_immune1.44168175
69MP0008932_abnormal_embryonic_tissue1.43714252
70MP0003011_delayed_dark_adaptation1.43482928
71MP0002638_abnormal_pupillary_reflex1.42936206
72MP0002139_abnormal_hepatobiliary_system1.41170734
73MP0002722_abnormal_immune_system1.40473352
74MP0005075_abnormal_melanosome_morpholog1.39780471
75MP0005000_abnormal_immune_tolerance1.38609656
76MP0002160_abnormal_reproductive_system1.36885327
77MP0002452_abnormal_antigen_presenting1.35887132
78MP0002019_abnormal_tumor_incidence1.35523754
79MP0002405_respiratory_system_inflammati1.35064766
80MP0002723_abnormal_immune_serum1.34687518
81MP0003724_increased_susceptibility_to1.34533173
82MP0002420_abnormal_adaptive_immunity1.32956676
83MP0001819_abnormal_immune_cell1.31680671
84MP0002429_abnormal_blood_cell1.31213286
85MP0004145_abnormal_muscle_electrophysio1.30503278
86MP0005389_reproductive_system_phenotype1.29887860
87MP0003787_abnormal_imprinting1.29837426
88MP0005646_abnormal_pituitary_gland1.28218150
89MP0005394_taste/olfaction_phenotype1.28143305
90MP0005499_abnormal_olfactory_system1.28143305
91MP0000716_abnormal_immune_system1.27108619
92MP0005464_abnormal_platelet_physiology1.26140616
93MP0001485_abnormal_pinna_reflex1.25957214
94MP0003646_muscle_fatigue1.24483807
95MP0001764_abnormal_homeostasis1.24456776
96MP0005410_abnormal_fertilization1.24275714
97MP0002419_abnormal_innate_immunity1.24037362
98MP0005171_absent_coat_pigmentation1.22976872
99MP0010155_abnormal_intestine_physiology1.22115721
100MP0001986_abnormal_taste_sensitivity1.21420502
101MP0000858_altered_metastatic_potential1.21087044
102MP0002928_abnormal_bile_duct1.20050494
103MP0002272_abnormal_nervous_system1.18540663
104MP0000313_abnormal_cell_death1.17727535
105MP0008775_abnormal_heart_ventricle1.16694543
106MP0003121_genomic_imprinting1.15705503
107MP0008469_abnormal_protein_level1.14902694
108MP0000343_altered_response_to1.14142530
109MP0005360_urolithiasis1.11221945
110MP0009745_abnormal_behavioral_response1.10456714
111MP0001845_abnormal_inflammatory_respons1.10345807
112MP0000015_abnormal_ear_pigmentation1.08793521
113MP0000703_abnormal_thymus_morphology1.08708966
114MP0005379_endocrine/exocrine_gland_phen1.08588511
115MP0008877_abnormal_DNA_methylation1.08132283
116MP0006292_abnormal_olfactory_placode1.07049114
117MP0000350_abnormal_cell_proliferation1.06724879
118MP0002751_abnormal_autonomic_nervous1.05907028
119MP0010352_gastrointestinal_tract_polyps1.05456562
120MP0008875_abnormal_xenobiotic_pharmacok1.04470834
121MP0002277_abnormal_respiratory_mucosa1.04087913
122MP0000465_gastrointestinal_hemorrhage1.03953789
123MP0002733_abnormal_thermal_nociception1.02451187
124MP0005085_abnormal_gallbladder_physiolo1.01685639
125MP0005332_abnormal_amino_acid0.99150167
126MP0010386_abnormal_urinary_bladder0.99074331
127MP0001730_embryonic_growth_arrest0.98815607
128MP0004215_abnormal_myocardial_fiber0.97317854
129MP0001919_abnormal_reproductive_system0.93426098
130MP0001970_abnormal_pain_threshold0.91500703
131MP0005319_abnormal_enzyme/_coenzyme0.91440958
132MP0005174_abnormal_tail_pigmentation0.91423747
133MP0009763_increased_sensitivity_to0.91052030
134MP0005408_hypopigmentation0.91035547
135MP0005387_immune_system_phenotype0.90960550
136MP0001790_abnormal_immune_system0.90960550
137MP0000647_abnormal_sebaceous_gland0.90688810
138MP0000631_abnormal_neuroendocrine_gland0.89831711
139MP0005636_abnormal_mineral_homeostasis0.89460359
140MP0005195_abnormal_posterior_eye0.88633785
141MP0003122_maternal_imprinting0.88045295
142MP0005365_abnormal_bile_salt0.87770951
143MP0003137_abnormal_impulse_conducting0.87741277
144MP0005083_abnormal_biliary_tract0.86752037
145MP0010307_abnormal_tumor_latency0.85451842
146MP0000598_abnormal_liver_morphology0.85377916
147MP0003890_abnormal_embryonic-extraembry0.85289668
148MP0003123_paternal_imprinting0.84998452
149MP0002557_abnormal_social/conspecific_i0.84706041
150MP0000749_muscle_degeneration0.84660427
151MP0009764_decreased_sensitivity_to0.83247464
152MP0000230_abnormal_systemic_arterial0.80529338
153MP0002572_abnormal_emotion/affect_behav0.80282255
154MP0002752_abnormal_somatic_nervous0.78798840
155MP0001119_abnormal_female_reproductive0.78335091
156MP0002095_abnormal_skin_pigmentation0.78247636
157MP0009643_abnormal_urine_homeostasis0.78164374
158MP0002067_abnormal_sensory_capabilities0.78107328
159MP0001293_anophthalmia0.77290642
160MP0003567_abnormal_fetal_cardiomyocyte0.76767047
161MP0005023_abnormal_wound_healing0.75182000
162MP0004924_abnormal_behavior0.74556035
163MP0005386_behavior/neurological_phenoty0.74556035
164MP0000609_abnormal_liver_physiology0.73935807
165MP0002210_abnormal_sex_determination0.73673255
166MP0006035_abnormal_mitochondrial_morpho0.73279854
167MP0000049_abnormal_middle_ear0.72952529
168MP0002080_prenatal_lethality0.72279364
169MP0000516_abnormal_urinary_system0.71717132
170MP0001697_abnormal_embryo_size0.70508174
171MP0000372_irregular_coat_pigmentation0.68148331
172MP0005266_abnormal_metabolism0.68134153
173MP0001873_stomach_inflammation0.67764409
174MP0000358_abnormal_cell_content/0.67243187
175MP0001929_abnormal_gametogenesis0.67241242

Predicted human phenotypes

RankGene SetZ-score
1Abnormal number of erythroid precursors (HP:0012131)4.85189459
2Abnormality of cells of the erythroid lineage (HP:0012130)4.78586623
3Reticulocytopenia (HP:0001896)4.37715373
4Molar tooth sign on MRI (HP:0002419)3.81511832
5Abnormality of midbrain morphology (HP:0002418)3.81511832
6Progressive macrocephaly (HP:0004481)3.78268656
7Pancreatic cysts (HP:0001737)3.75436601
8Aplastic anemia (HP:0001915)3.65454875
9Birth length less than 3rd percentile (HP:0003561)3.58456930
10Pancreatic fibrosis (HP:0100732)3.51320834
11Medial flaring of the eyebrow (HP:0010747)3.31770522
12Hepatic necrosis (HP:0002605)3.30588199
13Thrombocytosis (HP:0001894)3.28113975
14Oral leukoplakia (HP:0002745)3.23334499
15Abnormality of the heme biosynthetic pathway (HP:0010472)3.21319285
16Type II lissencephaly (HP:0007260)3.21218602
17True hermaphroditism (HP:0010459)3.20224249
18Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.17444876
19Macrocytic anemia (HP:0001972)3.15813167
20Pallor (HP:0000980)3.12594734
21Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.10754738
22Decreased activity of mitochondrial respiratory chain (HP:0008972)3.10754738
23Hepatocellular necrosis (HP:0001404)3.10345995
24Petechiae (HP:0000967)3.01797850
25Methylmalonic acidemia (HP:0002912)2.94807384
26Increased hepatocellular lipid droplets (HP:0006565)2.94444755
27Cerebral edema (HP:0002181)2.93603614
28Exertional dyspnea (HP:0002875)2.93570539
29Lipid accumulation in hepatocytes (HP:0006561)2.88376562
30Breast hypoplasia (HP:0003187)2.87308131
31Nephronophthisis (HP:0000090)2.85283208
32Type I transferrin isoform profile (HP:0003642)2.83203127
33Aplasia/Hypoplasia of the sacrum (HP:0008517)2.83192863
34Increased serum lactate (HP:0002151)2.82831561
35Microretrognathia (HP:0000308)2.81317199
3611 pairs of ribs (HP:0000878)2.78681508
37Methylmalonic aciduria (HP:0012120)2.76502969
38Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.74542579
39Chromsome breakage (HP:0040012)2.72329440
40Gait imbalance (HP:0002141)2.62809649
41Increased CSF lactate (HP:0002490)2.61078909
42Mitochondrial inheritance (HP:0001427)2.60773250
43Nausea (HP:0002018)2.59371850
44Increased intramyocellular lipid droplets (HP:0012240)2.58687722
45Congenital primary aphakia (HP:0007707)2.58632738
46Abnormality of the pons (HP:0007361)2.55993112
47Hypoplasia of the pons (HP:0012110)2.55649560
48Pancytopenia (HP:0001876)2.54962382
49Reduced antithrombin III activity (HP:0001976)2.53794382
50Respiratory difficulties (HP:0002880)2.47749474
51Abnormality of pyrimidine metabolism (HP:0004353)2.47523310
52Nephrogenic diabetes insipidus (HP:0009806)2.47253333
53Increased muscle lipid content (HP:0009058)2.46491991
543-Methylglutaconic aciduria (HP:0003535)2.45520450
55Chronic otitis media (HP:0000389)2.42533061
56Abnormality of the renal cortex (HP:0011035)2.41753119
57Optic disc pallor (HP:0000543)2.41004821
58Respiratory failure (HP:0002878)2.39601635
59Elevated erythrocyte sedimentation rate (HP:0003565)2.39508027
60IgM deficiency (HP:0002850)2.39441965
61Sclerocornea (HP:0000647)2.37450650
62Bile duct proliferation (HP:0001408)2.36391185
63Abnormal biliary tract physiology (HP:0012439)2.36391185
64Degeneration of anterior horn cells (HP:0002398)2.34155500
65Abnormality of the anterior horn cell (HP:0006802)2.34155500
66Abnormality of the renal medulla (HP:0100957)2.32484645
67Lethargy (HP:0001254)2.29521497
68Abnormal spermatogenesis (HP:0008669)2.29005671
69Cerebellar dysplasia (HP:0007033)2.28663558
70Abnormality of the preputium (HP:0100587)2.26873831
71Abnormality of chromosome stability (HP:0003220)2.25973612
72Congenital stationary night blindness (HP:0007642)2.25621500
73Recurrent abscess formation (HP:0002722)2.24373888
74Pendular nystagmus (HP:0012043)2.23684410
75Rough bone trabeculation (HP:0100670)2.22581953
76Renal cortical cysts (HP:0000803)2.21028603
77Bone marrow hypocellularity (HP:0005528)2.20620987
78Renal Fanconi syndrome (HP:0001994)2.20584598
79Chromosomal breakage induced by crosslinking agents (HP:0003221)2.18814517
80Concave nail (HP:0001598)2.16543847
81Poor head control (HP:0002421)2.15724369
82Large for gestational age (HP:0001520)2.15084188
83Lissencephaly (HP:0001339)2.14893016
84Retinal dysplasia (HP:0007973)2.14646781
85Severe muscular hypotonia (HP:0006829)2.14359766
86Abolished electroretinogram (ERG) (HP:0000550)2.14058751
87Lactic acidosis (HP:0003128)2.13986633
88Abnormal drinking behavior (HP:0030082)2.12476271
89Polydipsia (HP:0001959)2.12476271
90Multiple enchondromatosis (HP:0005701)2.11141326
91Colon cancer (HP:0003003)2.10070511
92CNS demyelination (HP:0007305)2.09031013
93Microcytic anemia (HP:0001935)2.08419315
94Delayed gross motor development (HP:0002194)2.04778308
95Hypothermia (HP:0002045)2.04302609
96Premature graying of hair (HP:0002216)2.03191458
97Hyperglycinemia (HP:0002154)2.02106631
98Selective tooth agenesis (HP:0001592)2.01720803
99Myelodysplasia (HP:0002863)2.01675186
100Abnormality of the labia minora (HP:0012880)2.00724527
101Sparse eyelashes (HP:0000653)2.00700291
102Aplasia/hypoplasia of the uterus (HP:0008684)1.99851330
103Progressive muscle weakness (HP:0003323)1.98984956
104Meckel diverticulum (HP:0002245)1.98870075
105Abnormality of dicarboxylic acid metabolism (HP:0010995)1.98020775
106Dicarboxylic aciduria (HP:0003215)1.98020775
107Microvesicular hepatic steatosis (HP:0001414)1.97698167
108Ketoacidosis (HP:0001993)1.96935279
109Aplasia/Hypoplasia of the tongue (HP:0010295)1.96930543
110Abnormality of reticulocytes (HP:0004312)1.96812310
111Type 2 muscle fiber atrophy (HP:0003554)1.95779780
112Muscle fiber atrophy (HP:0100295)1.95597270
113Acute necrotizing encephalopathy (HP:0006965)1.95241599
114Recurrent bronchitis (HP:0002837)1.94713855
115Cystic liver disease (HP:0006706)1.94694012
116Recurrent bacterial skin infections (HP:0005406)1.94149480
117Generalized aminoaciduria (HP:0002909)1.93691887
118Abnormal protein glycosylation (HP:0012346)1.93420798
119Abnormal glycosylation (HP:0012345)1.93420798
120Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.93420798
121Abnormal protein N-linked glycosylation (HP:0012347)1.93420798
122Prolonged bleeding time (HP:0003010)1.92729221
123Aplasia/Hypoplasia of the uvula (HP:0010293)1.92549451
124Increased serum ferritin (HP:0003281)1.92159286
125Polyphagia (HP:0002591)1.91839184
126Abnormal hemoglobin (HP:0011902)1.91194726
127Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.90296083
128Abnormality of alanine metabolism (HP:0010916)1.90296083
129Hyperalaninemia (HP:0003348)1.90296083
130Exercise intolerance (HP:0003546)1.89778562
131Abnormality of DNA repair (HP:0003254)1.89436562
132Abnormality of fatty-acid metabolism (HP:0004359)1.89427314
133Abnormality of the ileum (HP:0001549)1.89284851
134Lymphoma (HP:0002665)1.89115667
135Purpura (HP:0000979)1.88809948
136Megaloblastic anemia (HP:0001889)1.88414714
137Abnormality of T cell physiology (HP:0011840)1.88166806
138Congenital hepatic fibrosis (HP:0002612)1.87465825
139Tubular atrophy (HP:0000092)1.87098687
140Increased serum pyruvate (HP:0003542)1.86851106
141Absent thumb (HP:0009777)1.86579284
142Abnormal mitochondria in muscle tissue (HP:0008316)1.85725271
143Pustule (HP:0200039)1.85271328
144Inability to walk (HP:0002540)1.84172997
145Genital tract atresia (HP:0001827)1.83867465
146Vaginal atresia (HP:0000148)1.83093921
147Trismus (HP:0000211)1.82432093
148Progressive microcephaly (HP:0000253)1.82295475
149Poor coordination (HP:0002370)1.81064379
150Abnormality of monocarboxylic acid metabolism (HP:0010996)1.80553620
151Acute encephalopathy (HP:0006846)1.79891113
152Glycosuria (HP:0003076)1.78715058
153Abnormality of urine glucose concentration (HP:0011016)1.78715058
154Delayed CNS myelination (HP:0002188)1.78605282
155Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.76040259
156Hypoproteinemia (HP:0003075)1.75908617
157Clubbing of toes (HP:0100760)1.75625496
158Abnormality of T cells (HP:0002843)1.74740939
159Hypoplasia of the uterus (HP:0000013)1.74551857
160Abnormality of the renal collecting system (HP:0004742)1.73819542
161Cerebral hypomyelination (HP:0006808)1.72317040

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME23.46534529
2WEE13.37262632
3STK163.28122492
4BUB13.21269602
5ADRBK22.91041436
6EIF2AK12.90174696
7CDC72.71810966
8BRSK22.66380957
9BMPR1B2.54678942
10MAP4K22.54639438
11FRK2.46475403
12GRK12.40988677
13VRK22.28230893
14VRK12.24523492
15ACVR1B2.22216113
16MAP3K42.16169547
17MAP2K72.15885824
18TRIM282.14144154
19LIMK12.07347729
20WNK32.00598851
21BCKDK2.00444416
22PASK1.99416184
23PIM21.99058638
24MAP4K11.91181781
25NUAK11.82683827
26EIF2AK31.81128360
27PLK41.79249388
28SRPK11.75797031
29RPS6KA41.73646753
30PINK11.73357840
31TEC1.65531442
32CSNK1G31.54702766
33KDR1.52213423
34IRAK31.50143359
35IRAK41.49822661
36FLT31.45764072
37DYRK21.43487513
38TLK11.38148230
39MAPK131.37444165
40TYK21.35819334
41DYRK31.35415609
42SCYL21.33993791
43KIT1.33895872
44NEK21.33619232
45WNK41.32687249
46CSNK1G11.32171183
47CSNK1G21.31818895
48INSRR1.31064937
49TESK21.30978948
50BRSK11.30831978
51PLK11.27948803
52TXK1.27798942
53ZAP701.26355907
54RPS6KB21.25505992
55BLK1.24236319
56MST41.20352310
57CDK71.19621116
58CSNK1A1L1.16870815
59ZAK1.15072671
60AURKB1.15070925
61BCR1.14337755
62ATR1.12175502
63PIM11.11129572
64NME11.11036206
65BTK1.10677174
66TTK1.08924500
67MAP3K111.08467556
68PBK1.06655859
69PRKCG1.05696720
70NEK91.03256024
71ERBB31.03131759
72TBK11.02985095
73PHKG21.02227864
74PHKG11.02227864
75MKNK11.01554105
76PLK21.01294629
77STK100.99715011
78OXSR10.99315451
79CDK80.98054742
80CAMKK20.96857166
81ADRBK10.95491400
82MAP2K30.95416741
83STK40.92462672
84TGFBR10.91010267
85TNIK0.90896586
86PRKCE0.90501043
87MUSK0.88582228
88AURKA0.87779721
89NLK0.86258492
90IKBKE0.84325593
91CASK0.83147121
92TSSK60.82570303
93CDK40.81959802
94IKBKB0.81506978
95TAOK30.80843752
96CHEK20.80073067
97MAP3K120.78654110
98MARK10.78514131
99NEK10.78338194
100PAK30.76671912
101PDK20.74552571
102EIF2AK20.73885590
103STK390.73655108
104CSF1R0.73128420
105GRK70.72821130
106MAP3K80.71933195
107MAP3K30.70909679
108TESK10.69752526
109MAPKAPK30.69399422
110PAK40.69332049
111ABL20.68872528
112LRRK20.68226087
113CSNK2A10.65994728
114PTK2B0.65661104
115CCNB10.65600972
116MKNK20.62533173
117PIK3CG0.61389553
118DAPK20.58927144
119EPHA20.58444023
120LYN0.58404922
121MAP2K40.58128824
122TGFBR20.58115721
123LMTK20.57050136
124MAP3K140.56687959
125SYK0.56677762
126JAK30.56471781
127MINK10.55355927
128MAP2K60.55283280
129RPS6KA50.54167932
130CSNK2A20.53534915
131ERBB40.52900729
132PRKG20.52621249
133MATK0.51554503
134PDK40.48351584
135PDK30.48351584
136MYLK0.47494448
137CSNK1A10.46193439
138PRKCQ0.46130745
139DAPK30.45761507
140PNCK0.45386557
141PIK3CA0.45110132
142PLK30.44497883
143OBSCN0.44274604
144ERN10.43877177
145TRPM70.43258077
146GRK50.42851320
147TIE10.42547263
148MAP2K20.42420245
149BRAF0.41714345
150PRKCI0.39636676
151CAMK2A0.39273044
152PKN10.38898936
153CHEK10.36824889
154MAPKAPK50.36112095
155ATM0.35088710

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.61785162
2Ribosome_Homo sapiens_hsa030104.01034462
3Mismatch repair_Homo sapiens_hsa034303.54777025
4Proteasome_Homo sapiens_hsa030503.38581113
5Homologous recombination_Homo sapiens_hsa034402.92496475
6Base excision repair_Homo sapiens_hsa034102.72906963
7RNA polymerase_Homo sapiens_hsa030202.64725367
8Pyrimidine metabolism_Homo sapiens_hsa002402.54901979
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.40143625
10Nucleotide excision repair_Homo sapiens_hsa034202.33618693
11Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.18764412
12One carbon pool by folate_Homo sapiens_hsa006702.10688407
13Spliceosome_Homo sapiens_hsa030402.02893284
14Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.88079828
15Non-homologous end-joining_Homo sapiens_hsa034501.78967695
16RNA transport_Homo sapiens_hsa030131.73284712
17Fanconi anemia pathway_Homo sapiens_hsa034601.72943287
18Fatty acid elongation_Homo sapiens_hsa000621.70392945
19Protein export_Homo sapiens_hsa030601.67905949
20Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.66327658
21Butanoate metabolism_Homo sapiens_hsa006501.65798206
22Phototransduction_Homo sapiens_hsa047441.64742225
23Cell cycle_Homo sapiens_hsa041101.64573143
24Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.62762999
25Folate biosynthesis_Homo sapiens_hsa007901.56740991
26Sulfur metabolism_Homo sapiens_hsa009201.54061234
27RNA degradation_Homo sapiens_hsa030181.51840030
28Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.51691643
29Steroid biosynthesis_Homo sapiens_hsa001001.44133664
30Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.40174470
31Collecting duct acid secretion_Homo sapiens_hsa049661.36532520
32Basal transcription factors_Homo sapiens_hsa030221.36041690
33Pentose phosphate pathway_Homo sapiens_hsa000301.35815862
34Drug metabolism - other enzymes_Homo sapiens_hsa009831.33474374
35Cardiac muscle contraction_Homo sapiens_hsa042601.31361987
36Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.29891582
37Purine metabolism_Homo sapiens_hsa002301.25629731
38Glutathione metabolism_Homo sapiens_hsa004801.24965753
39Parkinsons disease_Homo sapiens_hsa050121.23768113
40Maturity onset diabetes of the young_Homo sapiens_hsa049501.20538272
41Nitrogen metabolism_Homo sapiens_hsa009101.18305510
42Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.14358801
43Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.13070385
44Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.12625465
45Linoleic acid metabolism_Homo sapiens_hsa005911.12620259
46Pentose and glucuronate interconversions_Homo sapiens_hsa000401.11272828
47Oxidative phosphorylation_Homo sapiens_hsa001901.10857639
48p53 signaling pathway_Homo sapiens_hsa041151.10412213
49Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.08443627
50Tryptophan metabolism_Homo sapiens_hsa003801.08205521
51Selenocompound metabolism_Homo sapiens_hsa004501.06789243
52Huntingtons disease_Homo sapiens_hsa050161.04184679
53alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.04101164
54Cysteine and methionine metabolism_Homo sapiens_hsa002701.01072272
55Antigen processing and presentation_Homo sapiens_hsa046121.00053159
56Cyanoamino acid metabolism_Homo sapiens_hsa004600.97508576
57Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.96010858
58Herpes simplex infection_Homo sapiens_hsa051680.95819205
59Primary immunodeficiency_Homo sapiens_hsa053400.93891240
60Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.92966524
61Caffeine metabolism_Homo sapiens_hsa002320.91792864
62Sulfur relay system_Homo sapiens_hsa041220.88665037
63Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.87990578
64Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.87955823
65Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.85404767
66Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.82870471
67Regulation of autophagy_Homo sapiens_hsa041400.81606267
68Carbon metabolism_Homo sapiens_hsa012000.80948322
69Legionellosis_Homo sapiens_hsa051340.78968554
70Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.78809632
71Ether lipid metabolism_Homo sapiens_hsa005650.77744494
72Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.77547709
73Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.77500818
74Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.76796263
75Biosynthesis of amino acids_Homo sapiens_hsa012300.76711943
76Epstein-Barr virus infection_Homo sapiens_hsa051690.74196875
77Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.72953802
78Systemic lupus erythematosus_Homo sapiens_hsa053220.70603681
79RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.70281488
80Vitamin B6 metabolism_Homo sapiens_hsa007500.69907813
81Peroxisome_Homo sapiens_hsa041460.67387528
82Chemical carcinogenesis_Homo sapiens_hsa052040.67001303
83Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.61709724
84Other glycan degradation_Homo sapiens_hsa005110.60827736
85Galactose metabolism_Homo sapiens_hsa000520.58746852
86Olfactory transduction_Homo sapiens_hsa047400.57915859
87Metabolic pathways_Homo sapiens_hsa011000.57890598
88Nicotine addiction_Homo sapiens_hsa050330.57308205
89Intestinal immune network for IgA production_Homo sapiens_hsa046720.57234667
90Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.57191576
91Measles_Homo sapiens_hsa051620.56858257
92Hematopoietic cell lineage_Homo sapiens_hsa046400.55912161
93Arachidonic acid metabolism_Homo sapiens_hsa005900.54163324
94Alzheimers disease_Homo sapiens_hsa050100.53363393
95Primary bile acid biosynthesis_Homo sapiens_hsa001200.53052611
96Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.49990995
97Fructose and mannose metabolism_Homo sapiens_hsa000510.49898879
98Arginine and proline metabolism_Homo sapiens_hsa003300.49166402
99Propanoate metabolism_Homo sapiens_hsa006400.47180695
100NF-kappa B signaling pathway_Homo sapiens_hsa040640.47028941
101N-Glycan biosynthesis_Homo sapiens_hsa005100.46847386
102Fatty acid metabolism_Homo sapiens_hsa012120.46332601
103mRNA surveillance pathway_Homo sapiens_hsa030150.45603274
104Leishmaniasis_Homo sapiens_hsa051400.45270130
105Fatty acid degradation_Homo sapiens_hsa000710.44722044
106Pyruvate metabolism_Homo sapiens_hsa006200.42640001
107Retinol metabolism_Homo sapiens_hsa008300.42285884
108Synaptic vesicle cycle_Homo sapiens_hsa047210.41729178
109Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.41206913
110Steroid hormone biosynthesis_Homo sapiens_hsa001400.39539290
111Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.39269028
112Glycosaminoglycan degradation_Homo sapiens_hsa005310.37052226
113Apoptosis_Homo sapiens_hsa042100.36975839
114Taste transduction_Homo sapiens_hsa047420.35228345
115Shigellosis_Homo sapiens_hsa051310.35150541
116Influenza A_Homo sapiens_hsa051640.35148005
117Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.34941085
118Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.34537900
119Alcoholism_Homo sapiens_hsa050340.34375104
120Allograft rejection_Homo sapiens_hsa053300.33513650
121Vibrio cholerae infection_Homo sapiens_hsa051100.33435316
122Morphine addiction_Homo sapiens_hsa050320.33418826
1232-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.33256057
124Vitamin digestion and absorption_Homo sapiens_hsa049770.32988681
125Rheumatoid arthritis_Homo sapiens_hsa053230.32224825
126Tyrosine metabolism_Homo sapiens_hsa003500.31775106
127Histidine metabolism_Homo sapiens_hsa003400.31739429
128Viral carcinogenesis_Homo sapiens_hsa052030.31513859
129beta-Alanine metabolism_Homo sapiens_hsa004100.31455671
130GABAergic synapse_Homo sapiens_hsa047270.30306326
131Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.28676341
132SNARE interactions in vesicular transport_Homo sapiens_hsa041300.28576452
133NOD-like receptor signaling pathway_Homo sapiens_hsa046210.28266236
134Renin-angiotensin system_Homo sapiens_hsa046140.27769422
135Pertussis_Homo sapiens_hsa051330.27669117
136HTLV-I infection_Homo sapiens_hsa051660.27304941

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