AKAP8L

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.66711925
2synaptic vesicle maturation (GO:0016188)5.65028758
3synaptic vesicle docking involved in exocytosis (GO:0016081)5.42153487
4positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.28947043
5locomotory exploration behavior (GO:0035641)5.01313456
6positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.78084059
7positive regulation of synaptic transmission, dopaminergic (GO:0032226)4.54838723
8synaptic vesicle exocytosis (GO:0016079)4.49435228
9regulation of synapse structural plasticity (GO:0051823)4.42250638
10membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.32796103
11mannose metabolic process (GO:0006013)4.30757303
12regulation of synaptic vesicle exocytosis (GO:2000300)4.27425616
13glutamate secretion (GO:0014047)4.24204968
14regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.19391638
15regulation of glutamate receptor signaling pathway (GO:1900449)4.14310835
16negative regulation of cytosolic calcium ion concentration (GO:0051481)4.13188196
17cerebellar Purkinje cell differentiation (GO:0021702)4.12991837
18sodium ion export (GO:0071436)4.05419002
19cellular potassium ion homeostasis (GO:0030007)4.00257997
20response to pheromone (GO:0019236)4.00118336
21cell communication by electrical coupling (GO:0010644)3.98882571
22neuromuscular process controlling posture (GO:0050884)3.97867961
23regulation of synaptic vesicle transport (GO:1902803)3.94142675
24neurotransmitter secretion (GO:0007269)3.92045851
25neurotransmitter-gated ion channel clustering (GO:0072578)3.88005467
26regulation of ARF protein signal transduction (GO:0032012)3.85964448
27cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.85792418
28regulation of neuronal synaptic plasticity (GO:0048168)3.78140608
29vocalization behavior (GO:0071625)3.73989133
30activation of protein kinase A activity (GO:0034199)3.56282890
313-UTR-mediated mRNA stabilization (GO:0070935)3.52424063
32positive regulation of synapse maturation (GO:0090129)3.51657874
33long-term memory (GO:0007616)3.48848485
34regulation of NFAT protein import into nucleus (GO:0051532)3.45590241
35regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.45220458
36glycine transport (GO:0015816)3.44696121
37membrane depolarization during action potential (GO:0086010)3.43889097
38response to muramyl dipeptide (GO:0032495)3.41512425
39negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.38731130
40protein localization to synapse (GO:0035418)3.37160020
41activation of MAPKKK activity (GO:0000185)3.34228342
42synaptic vesicle endocytosis (GO:0048488)3.30956687
43histone H4 deacetylation (GO:0070933)3.28594937
44ionotropic glutamate receptor signaling pathway (GO:0035235)3.27679245
45positive regulation of neurotransmitter secretion (GO:0001956)3.26467611
46synaptic transmission, glutamatergic (GO:0035249)3.25998240
47positive regulation of synaptic transmission, GABAergic (GO:0032230)3.23434019
48histone H3-K9 demethylation (GO:0033169)3.23347284
49negative regulation of cell size (GO:0045792)3.23050590
50neuronal action potential propagation (GO:0019227)3.22577830
51regulation of nucleobase-containing compound transport (GO:0032239)3.19366476
52positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr3.17948721
53modulation by symbiont of host cellular process (GO:0044068)3.17800509
54response to auditory stimulus (GO:0010996)3.17661867
55positive regulation of membrane potential (GO:0045838)3.16624655
56modulation by virus of host process (GO:0019054)3.15884884
57intracellular estrogen receptor signaling pathway (GO:0030520)3.14733354
58exploration behavior (GO:0035640)3.14512025
59auditory behavior (GO:0031223)3.14310351
60regulation of long-term neuronal synaptic plasticity (GO:0048169)3.14206010
61positive regulation of Rap GTPase activity (GO:0032854)3.13438851
62cytoskeletal anchoring at plasma membrane (GO:0007016)3.11238753
63potassium ion import (GO:0010107)3.09701535
64histone lysine demethylation (GO:0070076)3.09690340
65positive regulation of neurotransmitter transport (GO:0051590)3.07079499
66regulation of histone H3-K27 methylation (GO:0061085)3.06782097
67regulation of RNA export from nucleus (GO:0046831)3.06682268
68neuromuscular process controlling balance (GO:0050885)3.05083506
69G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.03952858
70regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.01131760
71positive regulation of gamma-delta T cell activation (GO:0046645)3.01033825
72gamma-aminobutyric acid transport (GO:0015812)3.01019249
73histone demethylation (GO:0016577)2.99849005
74Golgi transport vesicle coating (GO:0048200)2.99355120
75COPI coating of Golgi vesicle (GO:0048205)2.99355120
76potassium ion homeostasis (GO:0055075)2.97627855
77retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.97621704
78regulation of excitatory postsynaptic membrane potential (GO:0060079)2.97472589
79regulation of Rap GTPase activity (GO:0032317)2.95183877
80embryonic process involved in female pregnancy (GO:0060136)2.94926895
81positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.94693013
82neuronal ion channel clustering (GO:0045161)2.92012311
83histone H3-K36 demethylation (GO:0070544)2.91113487
84negative regulation of myotube differentiation (GO:0010832)2.90625782
85adherens junction assembly (GO:0034333)2.90576365
86prepulse inhibition (GO:0060134)2.90114163
87poly(A)+ mRNA export from nucleus (GO:0016973)2.87994095
88histone H3 deacetylation (GO:0070932)2.87490614
89regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.85302689
90neurotransmitter transport (GO:0006836)2.85213519
91apoptotic process involved in morphogenesis (GO:0060561)2.85036852
92regulation of postsynaptic membrane potential (GO:0060078)2.84621326
93positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.83311525
94regulation of ARF GTPase activity (GO:0032312)2.82947396
95glutamate receptor signaling pathway (GO:0007215)2.82544672
96semaphorin-plexin signaling pathway (GO:0071526)2.82322999
97germinal center formation (GO:0002467)2.81884228
98spliceosomal tri-snRNP complex assembly (GO:0000244)2.81298651
99striatum development (GO:0021756)2.80726935
100neuron-neuron synaptic transmission (GO:0007270)2.80611978
101cellular response to virus (GO:0098586)2.80279090
102regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.79316804
103focal adhesion assembly (GO:0048041)2.79168313
104cell-substrate adherens junction assembly (GO:0007045)2.79168313
105positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.78941046
106protein localization to endosome (GO:0036010)2.77972142
107regulation of synaptic plasticity (GO:0048167)2.76406713
108dopamine receptor signaling pathway (GO:0007212)2.75813289
109epithelial cell differentiation involved in prostate gland development (GO:0060742)2.75087573
110membrane depolarization (GO:0051899)2.73980937
111cellular sodium ion homeostasis (GO:0006883)2.72875774
112layer formation in cerebral cortex (GO:0021819)2.72799614
113regulation of synaptic transmission, glutamatergic (GO:0051966)2.72695961
114regulation of neurotransmitter secretion (GO:0046928)2.72416223
115RNA stabilization (GO:0043489)2.70874390
116mRNA stabilization (GO:0048255)2.70874390
117activation of JUN kinase activity (GO:0007257)2.70206296
118regulation of neurotransmitter levels (GO:0001505)2.69307989
119thymic T cell selection (GO:0045061)2.69095159
120negative regulation of erythrocyte differentiation (GO:0045647)2.69038675
121Peyers patch development (GO:0048541)2.68616529
122mucosal-associated lymphoid tissue development (GO:0048537)2.68616529
123regulation of membrane repolarization (GO:0060306)2.67805754
124dosage compensation (GO:0007549)2.65944715
125mechanosensory behavior (GO:0007638)2.65643792
126positive thymic T cell selection (GO:0045059)2.65543017
127regulation of chromatin binding (GO:0035561)2.65353296
128membrane hyperpolarization (GO:0060081)2.63139704
129positive regulation of CREB transcription factor activity (GO:0032793)2.63116789
130response to laminar fluid shear stress (GO:0034616)2.62594884
131activation of Rac GTPase activity (GO:0032863)2.61884812
132stress granule assembly (GO:0034063)2.61386101
133positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)2.60827671
134protein demethylation (GO:0006482)2.60272846
135protein dealkylation (GO:0008214)2.60272846
136regulation of type I interferon-mediated signaling pathway (GO:0060338)2.59895948
137regulation of neurotransmitter transport (GO:0051588)2.59631148
138regulation of synapse maturation (GO:0090128)2.58744138
139cAMP biosynthetic process (GO:0006171)2.58514630
140protein-DNA complex disassembly (GO:0032986)2.58281714
141nucleosome disassembly (GO:0006337)2.58281714
142NIK/NF-kappaB signaling (GO:0038061)2.57831902
143transmission of nerve impulse (GO:0019226)2.56978669
144planar cell polarity pathway involved in neural tube closure (GO:0090179)2.56033158
145positive regulation of potassium ion transmembrane transport (GO:1901381)2.55079047
146proline transport (GO:0015824)2.54432137
147membrane repolarization (GO:0086009)2.54263415
148regulation of cholesterol homeostasis (GO:2000188)2.53212845
149retrograde transport, endosome to Golgi (GO:0042147)2.52694118
150phosphatidylglycerol biosynthetic process (GO:0006655)2.52548675
151regulation of early endosome to late endosome transport (GO:2000641)2.52343717
152regulation of monocyte differentiation (GO:0045655)2.51928418
153alanine transport (GO:0032328)2.51825585
154establishment of nucleus localization (GO:0040023)2.51732212
155regulation of calcium ion-dependent exocytosis (GO:0017158)2.51462840
156signal complex assembly (GO:0007172)2.51437798
157barbed-end actin filament capping (GO:0051016)2.51009962
158regulation of vesicle fusion (GO:0031338)2.50967620
159neuromuscular synaptic transmission (GO:0007274)2.49891548
160regulation of mammary gland epithelial cell proliferation (GO:0033599)2.48377389
161positive regulation of Cdc42 GTPase activity (GO:0043089)2.45372599
162positive regulation of synaptic transmission (GO:0050806)2.45138894
163positive regulation of dendritic spine development (GO:0060999)2.44346146
164cerebellar Purkinje cell layer development (GO:0021680)2.44284791
165negative regulation of histone methylation (GO:0031061)2.43987876
166regulation of T-helper 2 cell differentiation (GO:0045628)2.42227750
167establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.41728573
168mitochondrion transport along microtubule (GO:0047497)2.41728573
169negative regulation of necroptotic process (GO:0060546)2.41651863
170regulation of glucose import in response to insulin stimulus (GO:2001273)2.41610972
171cell-cell junction maintenance (GO:0045217)2.41560394
172regulation of necroptotic process (GO:0060544)2.41554763
173response to peptidoglycan (GO:0032494)2.40798515
174neuromuscular process (GO:0050905)2.39972593
175regulation of gamma-delta T cell activation (GO:0046643)2.36331172
176regulation of gamma-delta T cell differentiation (GO:0045586)2.35418811
177peptidyl-tyrosine autophosphorylation (GO:0038083)2.34908984
178positive regulation of histone deacetylation (GO:0031065)2.34078035
179negative regulation of cell killing (GO:0031342)2.33316348
180negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.33316348
181regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.32951278
182activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.31549222
183cell migration in hindbrain (GO:0021535)2.30047571
184detection of bacterium (GO:0016045)2.27089982
185histone deacetylation (GO:0016575)2.25975899
186negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.25898969
187regulation of response to osmotic stress (GO:0047484)2.25443331
188cellular hyperosmotic response (GO:0071474)2.25175145
189negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.24475073
190negative regulation of toll-like receptor signaling pathway (GO:0034122)2.22645463
191maternal placenta development (GO:0001893)2.22319589
192positive regulation of nuclease activity (GO:0032075)2.20752053
193regulation of leukocyte degranulation (GO:0043300)2.20479947
194megakaryocyte development (GO:0035855)2.19622100

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.39863129
2RARB_27405468_Chip-Seq_BRAIN_Mouse3.44799147
3DROSHA_22980978_ChIP-Seq_HELA_Human3.24533733
4EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse3.19007818
5CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons3.00003125
6IKZF1_21737484_ChIP-ChIP_HCT116_Human2.97827071
7NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.69231375
8REST_21632747_ChIP-Seq_MESCs_Mouse2.66568151
9MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.50642567
10ELK3_25401928_ChIP-Seq_HUVEC_Human2.47023503
11REST_18959480_ChIP-ChIP_MESCs_Mouse2.41574082
12THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.39885558
13EGR1_19374776_ChIP-ChIP_THP-1_Human2.38373133
14TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.35993505
15* DNAJC2_21179169_ChIP-ChIP_NT2_Human2.34500108
16* MYC_22102868_ChIP-Seq_BL_Human2.20249579
17NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.13353059
18CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.07565450
19ZFP281_18757296_ChIP-ChIP_E14_Mouse2.02006377
20* KDM2B_26808549_Chip-Seq_DND41_Human2.01513216
21KDM2B_26808549_Chip-Seq_SUP-B15_Human2.01035779
22RACK7_27058665_Chip-Seq_MCF-7_Human1.99101258
23STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.96301524
24* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.95834673
25RARG_19884340_ChIP-ChIP_MEFs_Mouse1.90463509
26* LXR_22292898_ChIP-Seq_THP-1_Human1.89960508
27SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.87383186
28STAT6_21828071_ChIP-Seq_BEAS2B_Human1.83557015
29NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.83104502
30GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.80528035
31VDR_24763502_ChIP-Seq_THP-1_Human1.75051909
32TP63_17297297_ChIP-ChIP_HaCaT_Human1.74379692
33* TCF7_22412390_ChIP-Seq_EML_Mouse1.73414970
34KDM2B_26808549_Chip-Seq_K562_Human1.72166557
35* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.71976627
36GATA1_19941827_ChIP-Seq_MEL_Mouse1.68680730
37SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.67528466
38EZH2_27294783_Chip-Seq_ESCs_Mouse1.67526168
39SUZ12_27294783_Chip-Seq_ESCs_Mouse1.66173893
40DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.64563050
41CTCF_27219007_Chip-Seq_ERYTHROID_Human1.62221982
42* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.60753712
43MTF2_20144788_ChIP-Seq_MESCs_Mouse1.59824507
44TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.58724365
45MAF_26560356_Chip-Seq_TH2_Human1.57495699
46CIITA_25753668_ChIP-Seq_RAJI_Human1.56859807
47RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.56171547
48ERG_21242973_ChIP-ChIP_JURKAT_Human1.53316446
49JARID2_20075857_ChIP-Seq_MESCs_Mouse1.53101249
50NCOR1_26117541_ChIP-Seq_K562_Human1.52890247
51KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.51421356
52VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.51145484
53SCL_19346495_ChIP-Seq_HPC-7_Human1.51095234
54SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.51024725
55TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.49623660
56SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.48183663
57SPI1_23127762_ChIP-Seq_K562_Human1.47058990
58TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.45598789
59RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.44360771
60CLOCK_20551151_ChIP-Seq_293T_Human1.43444152
61SMC4_20622854_ChIP-Seq_HELA_Human1.43253421
62RUNX1_22412390_ChIP-Seq_EML_Mouse1.42666963
63UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.41611568
64SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.40675652
65MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.40346357
66P68_20966046_ChIP-Seq_HELA_Human1.38076951
67GATA1_19941826_ChIP-Seq_K562_Human1.37442820
68JARID2_20064375_ChIP-Seq_MESCs_Mouse1.36813204
69VDR_21846776_ChIP-Seq_THP-1_Human1.36766977
70RNF2_18974828_ChIP-Seq_MESCs_Mouse1.36392450
71EZH2_18974828_ChIP-Seq_MESCs_Mouse1.36392450
72GATA1_22025678_ChIP-Seq_K562_Human1.36267729
73PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.36165768
74ZFP281_27345836_Chip-Seq_ESCs_Mouse1.35202416
75KDM2B_26808549_Chip-Seq_JURKAT_Human1.33993318
76WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.32144628
77ESR2_21235772_ChIP-Seq_MCF-7_Human1.31875388
78P300_27058665_Chip-Seq_ZR-75-30cells_Human1.31856141
79LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.31844061
80RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.31754093
81DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.31551676
82ELF1_20517297_ChIP-Seq_JURKAT_Human1.28008395
83EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.27525101
84CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.27229452
85BRD4_27068464_Chip-Seq_AML-cells_Mouse1.26813869
86ZNF263_19887448_ChIP-Seq_K562_Human1.26305947
87GATA1_22383799_ChIP-Seq_G1ME_Mouse1.26007305
88* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.25721015
89PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.25215880
90SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.23868261
91CTCF_27219007_Chip-Seq_Bcells_Human1.23740154
92SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.22775172
93* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.21235875
94KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.20081544
95KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.18903084
96KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.18306673
97SRY_22984422_ChIP-ChIP_TESTIS_Rat1.17728601
98TET1_21490601_ChIP-Seq_MESCs_Mouse1.16793644
99GBX2_23144817_ChIP-Seq_PC3_Human1.16685836
100TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.15132225
101RNF2_27304074_Chip-Seq_ESCs_Mouse1.15024229
102NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.14664865
103SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.14656057
104SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.14479123
105BCOR_27268052_Chip-Seq_Bcells_Human1.14187263
106* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.14068121
107OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.13880938
108PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.11982644
109RUNX_20019798_ChIP-Seq_JUKART_Human1.11612730
110MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.10574950
111SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.10406697
112TP53_22127205_ChIP-Seq_IMR90_Human1.08752021
113SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.08112535
114SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.07418149
115TET1_21451524_ChIP-Seq_MESCs_Mouse1.07249102
116* BCL6_27268052_Chip-Seq_Bcells_Human1.06221011
117WT1_25993318_ChIP-Seq_PODOCYTE_Human1.06203348
118ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.05537382
119SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.05477650
120TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.05351566
121MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.04483636
122RUNX1_27514584_Chip-Seq_MCF-7_Human1.03161330
123UTX_26944678_Chip-Seq_JUKART_Human1.02536359
124NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.02497748
125ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.02278392
126BP1_19119308_ChIP-ChIP_Hs578T_Human1.01561569
127CREB1_26743006_Chip-Seq_LNCaP_Human1.01537870
128KLF4_18555785_ChIP-Seq_MESCs_Mouse1.00489615
129SA1_27219007_Chip-Seq_ERYTHROID_Human1.00284006
130LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.00134985
131GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99427824
132PU.1_20513432_ChIP-Seq_Bcells_Mouse0.99125029
133KLF4_19829295_ChIP-Seq_ESCs_Human0.98489414
134SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.98408230
135HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.98066478
136OCT4_19829295_ChIP-Seq_ESCs_Human0.97999582
137MAF_26560356_Chip-Seq_TH1_Human0.97605327
138EZH2_27304074_Chip-Seq_ESCs_Mouse0.97401892
139* CTCF_21964334_ChIP-Seq_BJAB-B_Human0.97154542
140CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.96893498
141AR_19668381_ChIP-Seq_PC3_Human0.95641141
142ATF3_27146783_Chip-Seq_COLON_Human0.93354729
143TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.93224464
144EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.93214697
145SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.92529850
146E2F1_20622854_ChIP-Seq_HELA_Human0.92111109
147ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.91896746
148GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.91535923
149SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.91502877
150PHF8_20622854_ChIP-Seq_HELA_Human0.91123738

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.02189099
2MP0009278_abnormal_bone_marrow3.67051110
3MP0002822_catalepsy3.46698066
4MP0003635_abnormal_synaptic_transmissio3.46463919
5MP0005058_abnormal_lysosome_morphology3.42948165
6MP0003303_peritoneal_inflammation3.20706921
7MP0008260_abnormal_autophagy3.19084654
8MP0005451_abnormal_body_composition3.14142407
9MP0003705_abnormal_hypodermis_morpholog3.03384511
10MP0005076_abnormal_cell_differentiation3.00547362
11MP0002909_abnormal_adrenal_gland3.00199250
12MP0003436_decreased_susceptibility_to2.80682178
13MP0009745_abnormal_behavioral_response2.67951473
14MP0003787_abnormal_imprinting2.59729631
15MP0002063_abnormal_learning/memory/cond2.58056787
16MP0002064_seizures2.51179479
17MP0009840_abnormal_foam_cell2.45590833
18MP0008961_abnormal_basal_metabolism2.43673163
19MP0009046_muscle_twitch2.38645649
20MP0001849_ear_inflammation2.28016675
21MP0008569_lethality_at_weaning2.22394694
22MP0009780_abnormal_chondrocyte_physiolo2.20981591
23MP0005423_abnormal_somatic_nervous2.19023524
24MP0004270_analgesia2.17576168
25MP0001545_abnormal_hematopoietic_system2.16205141
26MP0005397_hematopoietic_system_phenotyp2.16205141
27MP0005646_abnormal_pituitary_gland2.12321350
28MP0004185_abnormal_adipocyte_glucose2.12178602
29MP0002572_abnormal_emotion/affect_behav2.04812771
30MP0003880_abnormal_central_pattern1.98085134
31MP0003283_abnormal_digestive_organ1.96259485
32MP0003300_gastrointestinal_ulcer1.95502927
33MP0001348_abnormal_lacrimal_gland1.95366550
34MP0002272_abnormal_nervous_system1.94355308
35MP0001502_abnormal_circadian_rhythm1.89035413
36MP0003879_abnormal_hair_cell1.86661643
37MP0001486_abnormal_startle_reflex1.84736642
38MP0004947_skin_inflammation1.75497487
39MP0005666_abnormal_adipose_tissue1.74971846
40MP0003172_abnormal_lysosome_physiology1.71593819
41MP0001501_abnormal_sleep_pattern1.70220815
42MP0003191_abnormal_cellular_cholesterol1.65477672
43MP0003453_abnormal_keratinocyte_physiol1.59129160
44MP0001968_abnormal_touch/_nociception1.59119566
45MP0002557_abnormal_social/conspecific_i1.56840971
46MP0002396_abnormal_hematopoietic_system1.56340736
47MP0004145_abnormal_muscle_electrophysio1.51253569
48MP0004885_abnormal_endolymph1.51009974
49MP0004811_abnormal_neuron_physiology1.50560627
50MP0005409_darkened_coat_color1.50157258
51MP0000013_abnormal_adipose_tissue1.49651798
52MP0005375_adipose_tissue_phenotype1.47562589
53MP0000751_myopathy1.47326910
54MP0003633_abnormal_nervous_system1.46685160
55MP0004147_increased_porphyrin_level1.46206175
56MP0003690_abnormal_glial_cell1.45095339
57MP0003329_amyloid_beta_deposits1.44311352
58MP0001984_abnormal_olfaction1.43565285
59MP0004130_abnormal_muscle_cell1.42966927
60MP0002249_abnormal_larynx_morphology1.40363884
61MP0002734_abnormal_mechanical_nocicepti1.39372502
62MP0002653_abnormal_ependyma_morphology1.39162023
63MP0000569_abnormal_digit_pigmentation1.36817480
64MP0000604_amyloidosis1.36448168
65MP0005645_abnormal_hypothalamus_physiol1.34512606
66MP0002419_abnormal_innate_immunity1.32887866
67MP0002067_abnormal_sensory_capabilities1.32698414
68MP0004808_abnormal_hematopoietic_stem1.31673123
69MP0005025_abnormal_response_to1.31170337
70MP0002733_abnormal_thermal_nociception1.29871005
71MP0003091_abnormal_cell_migration1.29673469
72MP0003183_abnormal_peptide_metabolism1.29309706
73MP0003566_abnormal_cell_adhesion1.27882043
74MP0005670_abnormal_white_adipose1.26759755
75MP0001970_abnormal_pain_threshold1.26422846
76MP0002398_abnormal_bone_marrow1.24882326
77MP0000955_abnormal_spinal_cord1.24136514
78MP0000703_abnormal_thymus_morphology1.20254772
79MP0005000_abnormal_immune_tolerance1.19508643
80MP0004510_myositis1.19135383
81MP0004215_abnormal_myocardial_fiber1.16232816
82MP0004043_abnormal_pH_regulation1.14343348
83MP0000858_altered_metastatic_potential1.14305157
84MP0006292_abnormal_olfactory_placode1.13396912
85MP0002638_abnormal_pupillary_reflex1.13167773
86MP0002184_abnormal_innervation1.12306376
87MP0001440_abnormal_grooming_behavior1.12305502
88MP0010630_abnormal_cardiac_muscle1.12193945
89MP0010386_abnormal_urinary_bladder1.11538103
90MP0001790_abnormal_immune_system1.10329025
91MP0005387_immune_system_phenotype1.10329025
92MP0000685_abnormal_immune_system1.09890296
93MP0004233_abnormal_muscle_weight1.09625557
94MP0008874_decreased_physiological_sensi1.07808230
95MP0005621_abnormal_cell_physiology1.07635535
96MP0002735_abnormal_chemical_nociception1.06147513
97MP0001800_abnormal_humoral_immune1.05922424
98MP0005551_abnormal_eye_electrophysiolog1.05490320
99MP0009333_abnormal_splenocyte_physiolog1.05062841
100MP0008872_abnormal_physiological_respon1.04228063
101MP0002420_abnormal_adaptive_immunity1.04104153
102MP0001915_intracranial_hemorrhage1.04090118
103MP0003634_abnormal_glial_cell1.03744741
104MP0002066_abnormal_motor_capabilities/c1.03214905
105MP0002722_abnormal_immune_system1.02804091
106MP0004924_abnormal_behavior1.02774087
107MP0005386_behavior/neurological_phenoty1.02774087
108MP0001819_abnormal_immune_cell1.02627523
109MP0002069_abnormal_eating/drinking_beha1.02195510
110MP0002229_neurodegeneration1.01477472
111MP0004085_abnormal_heartbeat0.99066692
112MP0005464_abnormal_platelet_physiology0.98814721
113MP0002269_muscular_atrophy0.98392594
114MP0001851_eye_inflammation0.98280314
115MP0000716_abnormal_immune_system0.98005231
116MP0002009_preneoplasia0.97406743
117MP0002882_abnormal_neuron_morphology0.97303446
118MP0000733_abnormal_muscle_development0.96898261
119MP0001730_embryonic_growth_arrest0.96376854
120MP0002998_abnormal_bone_remodeling0.96348286
121MP0009672_abnormal_birth_weight0.96209816
122MP0005535_abnormal_body_temperature0.95557091
123MP0002452_abnormal_antigen_presenting0.95327220
124MP0003631_nervous_system_phenotype0.94233076
125MP0004036_abnormal_muscle_relaxation0.94203213
126MP0002723_abnormal_immune_serum0.94041334
127MP0001873_stomach_inflammation0.93901569
128MP0003122_maternal_imprinting0.93481084
129MP0002429_abnormal_blood_cell0.93406125
130MP0004142_abnormal_muscle_tone0.92804083
131MP0003075_altered_response_to0.92321854
132MP0003123_paternal_imprinting0.91175897
133MP0001533_abnormal_skeleton_physiology0.91097151
134MP0002736_abnormal_nociception_after0.90445934
135MP0000537_abnormal_urethra_morphology0.88703887
136MP0002078_abnormal_glucose_homeostasis0.88311776
137MP0002405_respiratory_system_inflammati0.87991700
138MP0006072_abnormal_retinal_apoptosis0.87473966
139MP0005499_abnormal_olfactory_system0.87170580
140MP0005394_taste/olfaction_phenotype0.87170580
141MP0004087_abnormal_muscle_fiber0.87023252
142MP0000689_abnormal_spleen_morphology0.85283855
143MP0000003_abnormal_adipose_tissue0.85193517
144MP0002693_abnormal_pancreas_physiology0.84308285
145MP0002837_dystrophic_cardiac_calcinosis0.84286110
146MP0009931_abnormal_skin_appearance0.83914409
147MP0004084_abnormal_cardiac_muscle0.83397660
148MP0004858_abnormal_nervous_system0.83007812
149MP0002933_joint_inflammation0.81455142
150MP0000747_muscle_weakness0.81447482
151MP0003866_abnormal_defecation0.81018485
152MP0003828_pulmonary_edema0.80820765
153MP0003656_abnormal_erythrocyte_physiolo0.80284350
154MP0002090_abnormal_vision0.80184522
155MP0003137_abnormal_impulse_conducting0.80119229
156MP0001944_abnormal_pancreas_morphology0.78804516
157MP0002877_abnormal_melanocyte_morpholog0.77276721
158MP0000678_abnormal_parathyroid_gland0.75999757
159MP0001765_abnormal_ion_homeostasis0.75996260
160MP0001835_abnormal_antigen_presentation0.75370318
161MP0004264_abnormal_extraembryonic_tissu0.75099645
162MP0000759_abnormal_skeletal_muscle0.75037316
163MP0010155_abnormal_intestine_physiology0.74468757
164MP0003953_abnormal_hormone_level0.74161010
165MP0003279_aneurysm0.73757741
166MP0002152_abnormal_brain_morphology0.73220445
167MP0000681_abnormal_thyroid_gland0.70527732
168MP0005384_cellular_phenotype0.70324180
169MP0003221_abnormal_cardiomyocyte_apopto0.70233213
170MP0003763_abnormal_thymus_physiology0.70034034
171MP0000313_abnormal_cell_death0.69375713
172MP0002089_abnormal_postnatal_growth/wei0.68114057
173MP0002928_abnormal_bile_duct0.67555992
174MP0000631_abnormal_neuroendocrine_gland0.67204720
175MP0001853_heart_inflammation0.66183930
176MP0003948_abnormal_gas_homeostasis0.66182450
177MP0000749_muscle_degeneration0.65501622
178MP0000371_diluted_coat_color0.63206455
179MP0002234_abnormal_pharynx_morphology0.62112505

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)4.94232554
2Myokymia (HP:0002411)4.71597600
3Visual hallucinations (HP:0002367)4.41632833
4Focal seizures (HP:0007359)4.08857456
5Epileptic encephalopathy (HP:0200134)3.82991566
6Obstructive sleep apnea (HP:0002870)3.42842769
7Postural instability (HP:0002172)3.35501780
8Ankle clonus (HP:0011448)3.33888365
9Abnormality of the lower motor neuron (HP:0002366)3.33338823
10Depression (HP:0000716)3.29470125
11Febrile seizures (HP:0002373)3.20887926
12Hemiplegia (HP:0002301)3.20315624
13Impaired smooth pursuit (HP:0007772)3.13726405
14Abnormality of the fingertips (HP:0001211)3.11308463
15Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.09571454
16Impaired social interactions (HP:0000735)3.05400461
17Abnormal social behavior (HP:0012433)3.05400461
18Poor eye contact (HP:0000817)3.02171317
19Insomnia (HP:0100785)3.01686528
20Spinal canal stenosis (HP:0003416)2.98391735
21Abnormality of ocular smooth pursuit (HP:0000617)2.87135470
22Progressive cerebellar ataxia (HP:0002073)2.86044982
23Annular pancreas (HP:0001734)2.85815988
24Neoplasm of the heart (HP:0100544)2.77150792
25Supranuclear gaze palsy (HP:0000605)2.74004520
26Impaired vibration sensation in the lower limbs (HP:0002166)2.73773611
27Broad face (HP:0000283)2.73653750
28Urinary bladder sphincter dysfunction (HP:0002839)2.73342993
29Bundle branch block (HP:0011710)2.73171970
30Eczematoid dermatitis (HP:0000976)2.67059676
31Reticulocytosis (HP:0001923)2.65931958
32Action tremor (HP:0002345)2.61590227
33Cellulitis (HP:0100658)2.58886870
34Neurofibrillary tangles (HP:0002185)2.55416243
35Metaphyseal cupping (HP:0003021)2.55133615
36Gaze-evoked nystagmus (HP:0000640)2.54562798
37Hyperacusis (HP:0010780)2.53420616
38Truncal ataxia (HP:0002078)2.53322462
39Status epilepticus (HP:0002133)2.52636634
40Dysmetric saccades (HP:0000641)2.50722471
41Pointed chin (HP:0000307)2.50555459
42Cerebral inclusion bodies (HP:0100314)2.48083837
43Hemiparesis (HP:0001269)2.47833380
44Dysdiadochokinesis (HP:0002075)2.47827972
45Absence seizures (HP:0002121)2.47723100
46Generalized tonic-clonic seizures (HP:0002069)2.44307214
47Bradykinesia (HP:0002067)2.43918707
48Abnormal gallbladder physiology (HP:0012438)2.43728092
49Cholecystitis (HP:0001082)2.43728092
50Atonic seizures (HP:0010819)2.43266323
51Genetic anticipation (HP:0003743)2.42905261
52Ventricular fibrillation (HP:0001663)2.41324371
53Segmental peripheral demyelination/remyelination (HP:0003481)2.39061914
54Distal lower limb amyotrophy (HP:0008944)2.36116966
55Torticollis (HP:0000473)2.35481908
56Decreased circulating renin level (HP:0003351)2.31690123
57Anxiety (HP:0000739)2.30780867
58Elfin facies (HP:0004428)2.29817346
59Truncus arteriosus (HP:0001660)2.24739920
60Bowel incontinence (HP:0002607)2.24067560
61Urinary urgency (HP:0000012)2.23875568
62Abnormal EKG (HP:0003115)2.22177728
63Limb ataxia (HP:0002070)2.21634203
64Increased IgE level (HP:0003212)2.21494812
65Focal dystonia (HP:0004373)2.20807163
66Dialeptic seizures (HP:0011146)2.15434419
67Deep palmar crease (HP:0006191)2.15293286
68Thin bony cortex (HP:0002753)2.13403161
69Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.12862901
70Dysmetria (HP:0001310)2.11515019
71Spastic gait (HP:0002064)2.11394397
72Disproportionate tall stature (HP:0001519)2.09947352
73Abnormality of binocular vision (HP:0011514)2.09063512
74Diplopia (HP:0000651)2.09063512
75Obsessive-compulsive behavior (HP:0000722)2.08876534
76Abnormal large intestine physiology (HP:0012700)2.07012249
77Cortical visual impairment (HP:0100704)2.06744223
78Peripheral hypomyelination (HP:0007182)2.05446032
79Prolonged QT interval (HP:0001657)2.04559727
80Long palpebral fissure (HP:0000637)2.03958586
81Ulnar bowing (HP:0003031)2.01964640
82Retinal atrophy (HP:0001105)2.01874414
83Abnormality of the thoracic spine (HP:0100711)2.01252556
84Increased connective tissue (HP:0009025)2.00977088
85Lower limb amyotrophy (HP:0007210)2.00911990
86Iris hypopigmentation (HP:0007730)1.99619784
87Ependymoma (HP:0002888)1.99440664
88Abnormal eating behavior (HP:0100738)1.98800701
89Stereotypic behavior (HP:0000733)1.98657125
90Exercise-induced myalgia (HP:0003738)1.98170876
91EEG with generalized epileptiform discharges (HP:0011198)1.97782913
92Craniofacial dystonia (HP:0012179)1.97710323
93Gastrointestinal inflammation (HP:0004386)1.97497045
94Atelectasis (HP:0100750)1.95929419
95Abnormality of saccadic eye movements (HP:0000570)1.95615337
96Epileptiform EEG discharges (HP:0011182)1.95219679
97Nuclear cataract (HP:0100018)1.94778580
98Ocular albinism (HP:0001107)1.94515669
99Clonus (HP:0002169)1.94511165
100Onion bulb formation (HP:0003383)1.92075945
101Abnormal delayed hypersensitivity skin test (HP:0002963)1.91018473
102Hypsarrhythmia (HP:0002521)1.90831029
103Hypertensive crisis (HP:0100735)1.90180050
104Chronic obstructive pulmonary disease (HP:0006510)1.90123591
105Obstructive lung disease (HP:0006536)1.90123591
106Hyperthyroidism (HP:0000836)1.88585785
107Mutism (HP:0002300)1.88548416
108J-shaped sella turcica (HP:0002680)1.87508290
109Hemorrhage of the eye (HP:0011885)1.87397781
110Rigidity (HP:0002063)1.87216179
111Psychosis (HP:0000709)1.86994516
112Hammertoe (HP:0001765)1.86855599
113Resting tremor (HP:0002322)1.86577216
114Subaortic stenosis (HP:0001682)1.85946828
115Abnormality of the left ventricular outflow tract (HP:0011103)1.85946828
116Polygenic inheritance (HP:0010982)1.85643730
117Bronchomalacia (HP:0002780)1.85525807
118Biconcave vertebral bodies (HP:0004586)1.85474818
119Thin ribs (HP:0000883)1.85202048
120Heart block (HP:0012722)1.85113689
121Turricephaly (HP:0000262)1.84362578
122Flat acetabular roof (HP:0003180)1.84055781
123Gingivitis (HP:0000230)1.83947238
124Macroorchidism (HP:0000053)1.83941503
125Neuronal loss in central nervous system (HP:0002529)1.83916904
126Thoracic kyphosis (HP:0002942)1.83781743
127Cervical subluxation (HP:0003308)1.83531431
128Abnormality of macrophages (HP:0004311)1.82695123
129Polycythemia (HP:0001901)1.82190962
130Hypercortisolism (HP:0001578)1.82048494
131Myopathic facies (HP:0002058)1.80144085
132Dysostosis multiplex (HP:0000943)1.79755883
133Renovascular hypertension (HP:0100817)1.78209015
134Distal upper limb amyotrophy (HP:0007149)1.78038980
135Upper limb amyotrophy (HP:0009129)1.78038980
136Panhypogammaglobulinemia (HP:0003139)1.77837905
137Seborrheic dermatitis (HP:0001051)1.77249469
138Difficulty climbing stairs (HP:0003551)1.77227119
139Precocious puberty (HP:0000826)1.76392926
140Slow saccadic eye movements (HP:0000514)1.75764909
141Asymmetric septal hypertrophy (HP:0001670)1.75606844
142Hyperinsulinemic hypoglycemia (HP:0000825)1.74586296
143Mediastinal lymphadenopathy (HP:0100721)1.72760513
144Foot dorsiflexor weakness (HP:0009027)1.72454959
145Impaired vibratory sensation (HP:0002495)1.72343235
146Mask-like facies (HP:0000298)1.71988710
147Scanning speech (HP:0002168)1.71633359
148Abnormality of the periventricular white matter (HP:0002518)1.71157659
149Cholelithiasis (HP:0001081)1.71048565
150Decreased motor nerve conduction velocity (HP:0003431)1.70243951
151Hypoglycemic seizures (HP:0002173)1.70060035
152Cerebral aneurysm (HP:0004944)1.69898280
153Colitis (HP:0002583)1.69824755
154Abnormal hair whorl (HP:0010721)1.69780185
155Hand muscle atrophy (HP:0009130)1.69589029
156Interstitial pulmonary disease (HP:0006530)1.69547175
157Centrally nucleated skeletal muscle fibers (HP:0003687)1.68942962
158Tetraplegia (HP:0002445)1.68916453
159Ankyloglossia (HP:0010296)1.68878153
160Achilles tendon contracture (HP:0001771)1.68654152
161Shallow orbits (HP:0000586)1.68653317
162Atrioventricular block (HP:0001678)1.67823251
163Hyperkalemia (HP:0002153)1.67783226
164Easy fatigability (HP:0003388)1.67227419
165Broad distal phalanx of finger (HP:0009836)1.67042371
166Mitral regurgitation (HP:0001653)1.66797553
167Growth hormone excess (HP:0000845)1.66724632
168Failure to thrive in infancy (HP:0001531)1.66691294
169Recurrent abscess formation (HP:0002722)1.65898382
170Progressive external ophthalmoplegia (HP:0000590)1.63747114
171Stridor (HP:0010307)1.63656326
172Broad palm (HP:0001169)1.62932482
173Patellar dislocation (HP:0002999)1.62570614
174Inflammation of the large intestine (HP:0002037)1.62344826
175Dislocated radial head (HP:0003083)1.62051087
176Deep venous thrombosis (HP:0002625)1.62029266
177Vertebral compression fractures (HP:0002953)1.61784770
178Personality changes (HP:0000751)1.61702562
179Distal sensory impairment (HP:0002936)1.61120510
180Aneurysm (HP:0002617)1.59828212
181Abnormality of reticulocytes (HP:0004312)1.58749701
182Lymphangioma (HP:0100764)1.57099788
183Recurrent bacterial skin infections (HP:0005406)1.56816511
184Supernumerary nipples (HP:0002558)1.56348743
185Increased cerebral lipofuscin (HP:0011813)1.56307393
186Increased variability in muscle fiber diameter (HP:0003557)1.56022223

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK33.81286919
2TNIK3.15828694
3EPHA42.95876154
4MAP3K92.95084856
5CDK122.86134948
6SMG12.77558141
7MAP3K132.56173423
8DAPK22.48545494
9SIK22.41379899
10MAP3K42.21976789
11PRKD32.17167423
12CDK191.91445788
13CAMKK11.85641457
14MAP3K101.84414302
15NTRK21.70877727
16MAP3K111.67491765
17CAMKK21.66766954
18MAP2K71.66758422
19MAP3K71.66296159
20CAMK11.63557782
21KSR21.61939096
22STK381.60401658
23PAK61.56791104
24SIK31.52284333
25DAPK11.45856185
26TRIB31.45082254
27EEF2K1.45072122
28MINK11.42806056
29IRAK31.41114054
30CAMK1G1.33519762
31TAOK21.32669670
32MAP2K41.31269447
33PRKCH1.29017134
34MARK21.27715664
35MTOR1.25874059
36RIPK11.25454004
37TAOK11.23955754
38FES1.21078811
39PKN21.20632748
40RIPK41.17457331
41TNK21.16690206
42CDC42BPA1.12762841
43CAMK41.10595855
44INSRR1.09856181
45TTN1.09718450
46MARK11.09299576
47PRPF4B1.08922092
48TBK11.08495222
49RET1.02406150
50CDK51.02108194
51PDGFRA1.00904785
52MAP3K31.00331121
53PINK11.00195006
54PHKG10.99413256
55PHKG20.99413256
56CAMK1D0.99202612
57LMTK20.98807620
58RAF10.97765000
59TYK20.97684990
60BRD40.94730315
61MAP4K10.93122917
62ICK0.92968370
63BMX0.92941703
64TGFBR20.92509841
65PTK60.92413670
66RPS6KC10.88686364
67RPS6KL10.88686364
68DYRK1B0.87416878
69NME20.85146237
70MAP3K140.84737436
71SGK30.84451502
72SIK10.83969219
73FGFR40.83701565
74SGK20.83212898
75UHMK10.81960885
76MAPK150.79041253
77KSR10.79020215
78MAP2K30.77376544
79ERN10.77092000
80PRKD20.76478020
81MAP3K10.74485245
82LATS20.74473033
83EPHB10.73590293
84TYRO30.72777554
85MAP3K20.70144205
86BTK0.69541337
87BCKDK0.69352533
88ARAF0.69295331
89TESK20.68964338
90BLK0.68894742
91WNK30.67855546
92MAPK130.66639658
93PDK10.66418351
94NEK10.65905635
95SGK2230.65860485
96SGK4940.65860485
97FGFR30.65756139
98MAP2K20.65168476
99PIM20.64819105
100CDK40.63089111
101CSK0.62558333
102RPS6KA60.62184337
103MAPKAPK30.61558105
104NTRK10.61343259
105JAK30.61016740
106ALK0.58950812
107TESK10.58591615
108FGR0.58436740
109MAPK110.58091826
110IRAK40.56656600
111MAPK120.55710954
112BRAF0.55353678
113PRKCG0.54587821
114MAP3K120.52730078
115DYRK1A0.51867337
116JAK10.51107948
117HCK0.51047881
118RPS6KA30.49983710
119HIPK20.49827449
120MAP3K80.49696363
121GRK60.49142399
122MAPK70.49077144
123DDR20.48998913
124ITK0.48955859
125RPS6KA20.48947274
126SGK10.48713071
127CDK60.47861214
128PAK30.47486424
129PTK2B0.46031063
130MAP2K60.45522634
131PRKAA10.44224798
132LRRK20.43593224
133ZAP700.43061694
134PDPK10.41669597
135RPS6KA10.41528179
136JAK20.41050298
137IRAK20.41030843
138MAPK80.40311034
139CDK90.40076062
140MAPK100.38900362
141SYK0.38644792
142DAPK30.38485944
143MAP3K60.38397015
144CDK11A0.38385782
145FLT30.37894891
146MUSK0.37654497
147SCYL20.36980505
148MAPK40.36749870
149CSF1R0.36088861
150STK110.35856014

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047212.87990856
2Olfactory transduction_Homo sapiens_hsa047402.63422534
3Circadian entrainment_Homo sapiens_hsa047132.61559837
4Insulin secretion_Homo sapiens_hsa049112.51958447
5Nicotine addiction_Homo sapiens_hsa050332.49374473
6Aldosterone synthesis and secretion_Homo sapiens_hsa049252.34711757
7Morphine addiction_Homo sapiens_hsa050322.32308457
8GABAergic synapse_Homo sapiens_hsa047272.28485866
9Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.11930977
10Long-term potentiation_Homo sapiens_hsa047202.08623484
11Glutamatergic synapse_Homo sapiens_hsa047242.05436180
12Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.02731591
13Amphetamine addiction_Homo sapiens_hsa050311.97200523
14Type II diabetes mellitus_Homo sapiens_hsa049301.96529731
15Chronic myeloid leukemia_Homo sapiens_hsa052201.96412052
16Circadian rhythm_Homo sapiens_hsa047101.77320684
17Salivary secretion_Homo sapiens_hsa049701.76917431
18Cholinergic synapse_Homo sapiens_hsa047251.72716446
19Dopaminergic synapse_Homo sapiens_hsa047281.70927447
20Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.61063497
21Calcium signaling pathway_Homo sapiens_hsa040201.59624912
22Oxytocin signaling pathway_Homo sapiens_hsa049211.58980022
23Gastric acid secretion_Homo sapiens_hsa049711.57067596
24Phosphatidylinositol signaling system_Homo sapiens_hsa040701.54349056
25Cocaine addiction_Homo sapiens_hsa050301.51538767
26Osteoclast differentiation_Homo sapiens_hsa043801.50933482
27Prion diseases_Homo sapiens_hsa050201.47878374
28Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.42575175
29Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.40565744
30Pancreatic cancer_Homo sapiens_hsa052121.39986679
31Renin secretion_Homo sapiens_hsa049241.38938524
32Taste transduction_Homo sapiens_hsa047421.37134391
33GnRH signaling pathway_Homo sapiens_hsa049121.33463302
34Carbohydrate digestion and absorption_Homo sapiens_hsa049731.30711024
35Bladder cancer_Homo sapiens_hsa052191.29978960
36Nitrogen metabolism_Homo sapiens_hsa009101.29765077
37Toll-like receptor signaling pathway_Homo sapiens_hsa046201.26941229
38cAMP signaling pathway_Homo sapiens_hsa040241.26098139
39AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.24686553
40Glucagon signaling pathway_Homo sapiens_hsa049221.19793405
41Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.18143264
42Renal cell carcinoma_Homo sapiens_hsa052111.13898619
43Leishmaniasis_Homo sapiens_hsa051401.11900109
44Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.11833917
45cGMP-PKG signaling pathway_Homo sapiens_hsa040221.07310016
46Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.06620171
47Estrogen signaling pathway_Homo sapiens_hsa049151.05779037
48Hepatitis B_Homo sapiens_hsa051611.03405338
49Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.02127110
50Neurotrophin signaling pathway_Homo sapiens_hsa047221.01242518
51Colorectal cancer_Homo sapiens_hsa052101.00252593
52Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.99567508
53Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.99407165
54Hepatitis C_Homo sapiens_hsa051600.99248537
55Longevity regulating pathway - mammal_Homo sapiens_hsa042110.97353234
56B cell receptor signaling pathway_Homo sapiens_hsa046620.97285218
57TNF signaling pathway_Homo sapiens_hsa046680.96889758
58Glycosaminoglycan degradation_Homo sapiens_hsa005310.95647313
59Inositol phosphate metabolism_Homo sapiens_hsa005620.95347390
60Influenza A_Homo sapiens_hsa051640.94996449
61Thyroid hormone signaling pathway_Homo sapiens_hsa049190.94406232
62Long-term depression_Homo sapiens_hsa047300.92850750
63Thyroid cancer_Homo sapiens_hsa052160.92716355
64Toxoplasmosis_Homo sapiens_hsa051450.92036144
65Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.91867007
66Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.90965171
67Pancreatic secretion_Homo sapiens_hsa049720.90893537
68mTOR signaling pathway_Homo sapiens_hsa041500.90621865
69NF-kappa B signaling pathway_Homo sapiens_hsa040640.90529085
70Gap junction_Homo sapiens_hsa045400.90192756
71Maturity onset diabetes of the young_Homo sapiens_hsa049500.90042098
72Apoptosis_Homo sapiens_hsa042100.89923003
73RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.89173915
74Dilated cardiomyopathy_Homo sapiens_hsa054140.88428868
75Phospholipase D signaling pathway_Homo sapiens_hsa040720.87398501
76Insulin signaling pathway_Homo sapiens_hsa049100.86756159
77Sphingolipid signaling pathway_Homo sapiens_hsa040710.85576708
78Tuberculosis_Homo sapiens_hsa051520.84485106
79Serotonergic synapse_Homo sapiens_hsa047260.84251718
80Leukocyte transendothelial migration_Homo sapiens_hsa046700.83873272
81ABC transporters_Homo sapiens_hsa020100.83626243
82Viral carcinogenesis_Homo sapiens_hsa052030.82759895
83Herpes simplex infection_Homo sapiens_hsa051680.82417620
84HIF-1 signaling pathway_Homo sapiens_hsa040660.81436836
85Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.80356644
86Salmonella infection_Homo sapiens_hsa051320.80103085
87Vascular smooth muscle contraction_Homo sapiens_hsa042700.79651196
88Amoebiasis_Homo sapiens_hsa051460.79577521
89Prostate cancer_Homo sapiens_hsa052150.79411691
90Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.79139865
91Lysine degradation_Homo sapiens_hsa003100.79068826
92Fructose and mannose metabolism_Homo sapiens_hsa000510.77906307
93Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.77442871
94Insulin resistance_Homo sapiens_hsa049310.77418148
95Lysosome_Homo sapiens_hsa041420.76992973
96FoxO signaling pathway_Homo sapiens_hsa040680.75894285
97MAPK signaling pathway_Homo sapiens_hsa040100.75123637
98VEGF signaling pathway_Homo sapiens_hsa043700.74948141
99Pentose phosphate pathway_Homo sapiens_hsa000300.73417121
100MicroRNAs in cancer_Homo sapiens_hsa052060.73203585
101Measles_Homo sapiens_hsa051620.72773304
102Malaria_Homo sapiens_hsa051440.72178546
103Glioma_Homo sapiens_hsa052140.72158103
104ErbB signaling pathway_Homo sapiens_hsa040120.71130476
105Non-small cell lung cancer_Homo sapiens_hsa052230.70460974
106HTLV-I infection_Homo sapiens_hsa051660.68956075
107Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.68652344
108Shigellosis_Homo sapiens_hsa051310.68529231
109Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.67433505
110Adipocytokine signaling pathway_Homo sapiens_hsa049200.67402178
111Thyroid hormone synthesis_Homo sapiens_hsa049180.66785612
112Platelet activation_Homo sapiens_hsa046110.65962402
113Adherens junction_Homo sapiens_hsa045200.63182526
114Proteoglycans in cancer_Homo sapiens_hsa052050.62801258
115mRNA surveillance pathway_Homo sapiens_hsa030150.62761924
116Transcriptional misregulation in cancer_Homo sapiens_hsa052020.61759738
117Bile secretion_Homo sapiens_hsa049760.61003372
118Choline metabolism in cancer_Homo sapiens_hsa052310.59611489
119Small cell lung cancer_Homo sapiens_hsa052220.58798345
1202-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.57442262
121T cell receptor signaling pathway_Homo sapiens_hsa046600.57408924
122Primary immunodeficiency_Homo sapiens_hsa053400.57007390
123Focal adhesion_Homo sapiens_hsa045100.56042762
124Notch signaling pathway_Homo sapiens_hsa043300.55808993
125Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.55527188
126Melanogenesis_Homo sapiens_hsa049160.55083312
127Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.54998090
128Regulation of autophagy_Homo sapiens_hsa041400.54807186
129Endocytosis_Homo sapiens_hsa041440.54350176
130Chemokine signaling pathway_Homo sapiens_hsa040620.54188500
131Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.53796843
132Pertussis_Homo sapiens_hsa051330.52579419
133NOD-like receptor signaling pathway_Homo sapiens_hsa046210.52246664
134Jak-STAT signaling pathway_Homo sapiens_hsa046300.51526955
135Glycerophospholipid metabolism_Homo sapiens_hsa005640.51109328
136Prolactin signaling pathway_Homo sapiens_hsa049170.50999889
137Collecting duct acid secretion_Homo sapiens_hsa049660.49835750
138Galactose metabolism_Homo sapiens_hsa000520.49506419
139Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.46250133
140Rap1 signaling pathway_Homo sapiens_hsa040150.45841206
141Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.44986294
142Central carbon metabolism in cancer_Homo sapiens_hsa052300.43386288
143Acute myeloid leukemia_Homo sapiens_hsa052210.42923498
144Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.42871926
145Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.42708697
146Oocyte meiosis_Homo sapiens_hsa041140.42703765
147Endometrial cancer_Homo sapiens_hsa052130.42674946
148Other glycan degradation_Homo sapiens_hsa005110.41601999
149Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.41115758
150AMPK signaling pathway_Homo sapiens_hsa041520.40033934
151Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.38998734
152Alcoholism_Homo sapiens_hsa050340.35640670

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