AKAP17A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This locus encodes a protein kinase A anchoring protein. The encoded protein is part of the spliceosome complex and is involved in the regulation of alternate splicing in some mRNA precursors. Alternatively spliced transcript variants have been identified for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)5.52915052
2negative regulation of erythrocyte differentiation (GO:0045647)5.15081169
3negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.77459369
4negative regulation of cell killing (GO:0031342)4.77459369
5antigen processing and presentation of endogenous antigen (GO:0019883)4.72597927
6antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.70114970
7antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.42032621
8positive regulation by symbiont of host defense response (GO:0052509)4.40898753
9modulation by symbiont of host defense response (GO:0052031)4.40898753
10modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.40898753
11modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.40898753
12positive regulation by organism of defense response of other organism involved in symbiotic interact4.40898753
13modulation by symbiont of host immune response (GO:0052553)4.40898753
14regulation of gamma-delta T cell activation (GO:0046643)4.27466988
15antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.23710991
16detection of bacterium (GO:0016045)4.11408405
17response to muramyl dipeptide (GO:0032495)4.08616162
18detection of other organism (GO:0098543)4.04066829
19positive thymic T cell selection (GO:0045059)3.98327560
20regulation of gamma-delta T cell differentiation (GO:0045586)3.94813686
21negative thymic T cell selection (GO:0045060)3.93732942
22response to peptidoglycan (GO:0032494)3.92335329
23mannose metabolic process (GO:0006013)3.82084962
24regulation of B cell receptor signaling pathway (GO:0050855)3.81850501
25thymic T cell selection (GO:0045061)3.76372791
26negative T cell selection (GO:0043383)3.68734119
27positive regulation of B cell differentiation (GO:0045579)3.67882589
28B cell receptor signaling pathway (GO:0050853)3.66098623
29positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.64840199
30leukocyte aggregation (GO:0070486)3.60966837
31macrophage activation involved in immune response (GO:0002281)3.54638010
32neutrophil activation involved in immune response (GO:0002283)3.52941999
33T cell selection (GO:0045058)3.50621517
34positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.48780933
35germinal center formation (GO:0002467)3.43690026
36immunoglobulin mediated immune response (GO:0016064)3.38839775
37positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.36479118
38regulation of B cell differentiation (GO:0045577)3.35039298
39cellular extravasation (GO:0045123)3.34320218
40NIK/NF-kappaB signaling (GO:0038061)3.32533373
41negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.32405477
42positive T cell selection (GO:0043368)3.26518170
43detection of external biotic stimulus (GO:0098581)3.21806584
44negative regulation of lymphocyte mediated immunity (GO:0002707)3.20660272
45regulation of dendritic cell antigen processing and presentation (GO:0002604)3.20192669
46regulation of interferon-beta biosynthetic process (GO:0045357)3.18299316
47histone H3-K36 demethylation (GO:0070544)3.17325984
48tolerance induction (GO:0002507)3.15727033
49regulation of mast cell degranulation (GO:0043304)3.12666958
50negative regulation of leukocyte mediated immunity (GO:0002704)3.12578653
51defense response to protozoan (GO:0042832)3.11707384
52negative regulation of T cell mediated immunity (GO:0002710)3.09151656
53response to protozoan (GO:0001562)3.08720753
54T cell migration (GO:0072678)3.05830990
55regulation of leukocyte degranulation (GO:0043300)3.03428705
56negative regulation of interleukin-12 production (GO:0032695)3.03002294
57response to type I interferon (GO:0034340)3.02210214
58cellular response to type I interferon (GO:0071357)3.01142542
59type I interferon signaling pathway (GO:0060337)3.01142542
60regulation of myeloid leukocyte mediated immunity (GO:0002886)2.99156114
61regulation of T-helper 2 cell differentiation (GO:0045628)2.94888817
62regulation of type I interferon-mediated signaling pathway (GO:0060338)2.89671411
63detection of biotic stimulus (GO:0009595)2.88089399
64response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.84613790
65response to host immune response (GO:0052572)2.84613790
66CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.80684747
67response to interleukin-15 (GO:0070672)2.80641937
68regulation of mast cell activation involved in immune response (GO:0033006)2.78086395
69mucosal-associated lymphoid tissue development (GO:0048537)2.76459073
70Peyers patch development (GO:0048541)2.76459073
71regulation of antigen processing and presentation (GO:0002577)2.76408691
72response to host (GO:0075136)2.76057277
73response to host defenses (GO:0052200)2.76057277
74response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.76057277
75negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.76029472
76B cell homeostasis (GO:0001782)2.75688563
773-UTR-mediated mRNA stabilization (GO:0070935)2.74263559
78interferon-gamma-mediated signaling pathway (GO:0060333)2.73852223
79antigen processing and presentation via MHC class Ib (GO:0002475)2.69788014
80myeloid cell activation involved in immune response (GO:0002275)2.69498589
81negative regulation of toll-like receptor signaling pathway (GO:0034122)2.69130236
82response to laminar fluid shear stress (GO:0034616)2.67300094
83regulation of T cell tolerance induction (GO:0002664)2.65499986
84respiratory burst (GO:0045730)2.64153868
85embryonic process involved in female pregnancy (GO:0060136)2.64118020
86positive regulation of antigen processing and presentation (GO:0002579)2.63555816
87positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.62883137
88negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.62670708
89negative regulation of T-helper cell differentiation (GO:0045623)2.62670708
90negative regulation of type 2 immune response (GO:0002829)2.62557350
91negative regulation of innate immune response (GO:0045824)2.61358934
92regulation of T-helper 1 cell differentiation (GO:0045625)2.61034714
93lipopolysaccharide-mediated signaling pathway (GO:0031663)2.60601656
94negative regulation of interleukin-6 production (GO:0032715)2.60400099
95detection of molecule of bacterial origin (GO:0032490)2.60297317
96regulation of interleukin-2 biosynthetic process (GO:0045076)2.58784011
97negative regulation of phagocytosis (GO:0050765)2.58636276
98neutrophil activation (GO:0042119)2.57455790
99negative regulation of cytokine production involved in immune response (GO:0002719)2.56774801
100positive regulation of granulocyte differentiation (GO:0030854)2.56575812

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1VDR_21846776_ChIP-Seq_THP-1_Human3.63323954
2MYC_22102868_ChIP-Seq_BL_Human3.61337879
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.39983853
4EGR1_19374776_ChIP-ChIP_THP-1_Human2.99526570
5KDM2B_26808549_Chip-Seq_SUP-B15_Human2.71135183
6MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.69162941
7TCF7_22412390_ChIP-Seq_EML_Mouse2.64717239
8KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.60640323
9STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.55810599
10NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.54611598
11BP1_19119308_ChIP-ChIP_Hs578T_Human2.52396362
12VDR_24763502_ChIP-Seq_THP-1_Human2.52249964
13KDM2B_26808549_Chip-Seq_DND41_Human2.43764351
14MAF_26560356_Chip-Seq_TH1_Human2.38914833
15THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.31923106
16ELK3_25401928_ChIP-Seq_HUVEC_Human2.29548373
17LXR_22292898_ChIP-Seq_THP-1_Human2.25596779
18FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.24644276
19NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.23600572
20SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.23129804
21E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.21641579
22KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.16809949
23UTX_26944678_Chip-Seq_JUKART_Human2.16304666
24NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.07309441
25VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.06333778
26TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.04604796
27SCL_19346495_ChIP-Seq_HPC-7_Human2.03026737
28RUNX1_22412390_ChIP-Seq_EML_Mouse2.01145394
29MAF_26560356_Chip-Seq_TH2_Human2.00862104
30BRD4_27068464_Chip-Seq_AML-cells_Mouse1.90613149
31RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.89796376
32SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.89698058
33MYB_21317192_ChIP-Seq_ERMYB_Mouse1.86826424
34IRF8_27001747_Chip-Seq_BMDM_Mouse1.83890244
35IRF8_21731497_ChIP-ChIP_J774_Mouse1.81661935
36FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.81413409
37MYB_26560356_Chip-Seq_TH1_Human1.79639437
38SPI1_23547873_ChIP-Seq_NB4_Human1.78478278
39MYB_26560356_Chip-Seq_TH2_Human1.74495045
40RUNX_20019798_ChIP-Seq_JUKART_Human1.74089307
41TP63_17297297_ChIP-ChIP_HaCaT_Human1.73570394
42SPI1_23127762_ChIP-Seq_K562_Human1.71447021
43KDM2B_26808549_Chip-Seq_JURKAT_Human1.68882923
44IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.67518289
45STAT4_19710469_ChIP-ChIP_TH1__Mouse1.66821843
46STAT6_21828071_ChIP-Seq_BEAS2B_Human1.65433750
47STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.60721263
48RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.60634400
49TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.56948203
50RACK7_27058665_Chip-Seq_MCF-7_Human1.55198300
51MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.45501295
52NCOR1_26117541_ChIP-Seq_K562_Human1.40750534
53GATA1_22383799_ChIP-Seq_G1ME_Mouse1.37327602
54IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.37133263
55SA1_27219007_Chip-Seq_ERYTHROID_Human1.36821537
56CTCF_27219007_Chip-Seq_ERYTHROID_Human1.36783991
57KDM2B_26808549_Chip-Seq_K562_Human1.36414636
58GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.34685266
59GATA1_19941827_ChIP-Seq_MEL_Mouse1.34544001
60PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.33588510
61ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.33401796
62RARG_19884340_ChIP-ChIP_MEFs_Mouse1.32374483
63SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.32146267
64GATA2_22383799_ChIP-Seq_G1ME_Mouse1.28500377
65GATA1_19941826_ChIP-Seq_K562_Human1.28217895
66P68_20966046_ChIP-Seq_HELA_Human1.26699919
67PU.1_20513432_ChIP-Seq_Bcells_Mouse1.24079415
68BCOR_27268052_Chip-Seq_Bcells_Human1.22472504
69EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.22114749
70ELF1_20517297_ChIP-Seq_JURKAT_Human1.20630996
71KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.17372941
72CIITA_25753668_ChIP-Seq_RAJI_Human1.17029219
73BCL6_27268052_Chip-Seq_Bcells_Human1.15404566
74TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.11858963
75KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.11522667
76CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.10293743
77CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.10029369
78PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.08884296
79EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.08815939
80SMC4_20622854_ChIP-Seq_HELA_Human1.08756438
81GATA3_27048872_Chip-Seq_THYMUS_Human1.04996282
82CREB1_26743006_Chip-Seq_LNCaP_Human1.04722965
83TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.02411008
84SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.02241666
85FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.00977333
86LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.00657358
87STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.99028615
88GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.98996224
89TET1_21451524_ChIP-Seq_MESCs_Mouse0.97629264
90ZFP281_18757296_ChIP-ChIP_E14_Mouse0.97063922
91PU_27001747_Chip-Seq_BMDM_Mouse0.96643681
92VDR_24787735_ChIP-Seq_THP-1_Human0.96639853
93UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.96355198
94SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.94038806
95RUNX1_27514584_Chip-Seq_MCF-7_Human0.92560520
96RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91975841
97DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.91197241
98SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.90854327
99P300_27058665_Chip-Seq_ZR-75-30cells_Human0.90716357
100CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.90257502

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003436_decreased_susceptibility_to4.05747065
2MP0003303_peritoneal_inflammation3.67839954
3MP0001835_abnormal_antigen_presentation3.05547332
4MP0003763_abnormal_thymus_physiology2.90582726
5MP0001800_abnormal_humoral_immune2.71668327
6MP0000685_abnormal_immune_system2.63566425
7MP0005387_immune_system_phenotype2.62155805
8MP0001790_abnormal_immune_system2.62155805
9MP0005000_abnormal_immune_tolerance2.57878418
10MP0005025_abnormal_response_to2.48317241
11MP0003724_increased_susceptibility_to2.47239785
12MP0002419_abnormal_innate_immunity2.44457025
13MP0009278_abnormal_bone_marrow2.42363352
14MP0005671_abnormal_response_to2.40495927
15MP0003300_gastrointestinal_ulcer2.35500980
16MP0002723_abnormal_immune_serum2.33838885
17MP0002420_abnormal_adaptive_immunity2.28176021
18MP0002452_abnormal_antigen_presenting2.27380849
19MP0001819_abnormal_immune_cell2.25505913
20MP0003172_abnormal_lysosome_physiology2.21329494
21MP0008260_abnormal_autophagy2.15947356
22MP0004947_skin_inflammation2.13528549
23MP0009333_abnormal_splenocyte_physiolog2.12699345
24MP0001545_abnormal_hematopoietic_system2.11881931
25MP0005397_hematopoietic_system_phenotyp2.11881931
26MP0002396_abnormal_hematopoietic_system2.11493344
27MP0002132_abnormal_respiratory_system2.08800369
28MP0009785_altered_susceptibility_to2.08216365
29MP0002398_abnormal_bone_marrow2.06728251
30MP0005451_abnormal_body_composition2.02588807
31MP0010155_abnormal_intestine_physiology1.92278246
32MP0002405_respiratory_system_inflammati1.90811467
33MP0000716_abnormal_immune_system1.89377485
34MP0002148_abnormal_hypersensitivity_rea1.84214278
35MP0005058_abnormal_lysosome_morphology1.79765567
36MP0005464_abnormal_platelet_physiology1.76172877
37MP0001533_abnormal_skeleton_physiology1.72326578
38MP0000703_abnormal_thymus_morphology1.69787216
39MP0001873_stomach_inflammation1.68319535
40MP0003191_abnormal_cellular_cholesterol1.67738732
41MP0002722_abnormal_immune_system1.67645304
42MP0005076_abnormal_cell_differentiation1.65574749
43MP0000689_abnormal_spleen_morphology1.60625470
44MP0002429_abnormal_blood_cell1.58046041
45MP0006082_CNS_inflammation1.52986279
46MP0001853_heart_inflammation1.52388436
47MP0001845_abnormal_inflammatory_respons1.49513253
48MP0004808_abnormal_hematopoietic_stem1.49287234
49MP0000858_altered_metastatic_potential1.46575624
50MP0004510_myositis1.39290051
51MP0009840_abnormal_foam_cell1.35303096
52MP0003828_pulmonary_edema1.35184382
53MP0003705_abnormal_hypodermis_morpholog1.32585161
54MP0002998_abnormal_bone_remodeling1.32307959
55MP0001851_eye_inflammation1.28441049
56MP0000465_gastrointestinal_hemorrhage1.25109317
57MP0008469_abnormal_protein_level1.22934941
58MP0003866_abnormal_defecation1.22096562
59MP0004381_abnormal_hair_follicle1.21287789
60MP0003183_abnormal_peptide_metabolism1.18902735
61MP0002166_altered_tumor_susceptibility1.18735311
62MP0003453_abnormal_keratinocyte_physiol1.16995368
63MP0005310_abnormal_salivary_gland1.15234798
64MP0002933_joint_inflammation1.13321309
65MP0003091_abnormal_cell_migration1.09096527
66MP0004185_abnormal_adipocyte_glucose1.08200247
67MP0002138_abnormal_hepatobiliary_system1.06403365
68MP0001849_ear_inflammation1.04509955
69MP0008004_abnormal_stomach_pH1.00955590
70MP0000490_abnormal_crypts_of1.00923367
71MP0005666_abnormal_adipose_tissue0.91538421
72MP0002009_preneoplasia0.88772517
73MP0005390_skeleton_phenotype0.85154379
74MP0001663_abnormal_digestive_system0.84923213
75MP0009764_decreased_sensitivity_to0.84578357
76MP0000678_abnormal_parathyroid_gland0.83413042
77MP0003566_abnormal_cell_adhesion0.79530381
78MP0003279_aneurysm0.79454891
79MP0005166_decreased_susceptibility_to0.77529258
80MP0003075_altered_response_to0.76063442
81MP0005375_adipose_tissue_phenotype0.75200675
82MP0002006_tumorigenesis0.75041260
83MP0005409_darkened_coat_color0.74229894
84MP0004883_abnormal_blood_vessel0.73553711
85MP0003448_altered_tumor_morphology0.72748174
86MP0004264_abnormal_extraembryonic_tissu0.72362266
87MP0003795_abnormal_bone_structure0.70470265
88MP0002019_abnormal_tumor_incidence0.70096142
89MP0005360_urolithiasis0.69874821
90MP0001348_abnormal_lacrimal_gland0.69801553
91MP0009931_abnormal_skin_appearance0.69482662
92MP0003656_abnormal_erythrocyte_physiolo0.67432501
93MP0005164_abnormal_response_to0.66620703
94MP0008874_decreased_physiological_sensi0.65596195
95MP0000249_abnormal_blood_vessel0.64339435
96MP0005621_abnormal_cell_physiology0.62295883
97MP0000604_amyloidosis0.61460328
98MP0000767_abnormal_smooth_muscle0.60171265
99MP0009115_abnormal_fat_cell0.59307796
100MP0009763_increased_sensitivity_to0.58807835

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)5.26582787
2Recurrent bacterial skin infections (HP:0005406)4.00884032
3Recurrent abscess formation (HP:0002722)3.87950799
4Abnormality of macrophages (HP:0004311)3.87734157
5Myositis (HP:0100614)3.77880120
6Increased IgE level (HP:0003212)3.68892483
7Mediastinal lymphadenopathy (HP:0100721)3.58271669
8Meningitis (HP:0001287)3.56696635
9Abnormal delayed hypersensitivity skin test (HP:0002963)3.51281651
10Recurrent fungal infections (HP:0002841)3.47435653
11Cellulitis (HP:0100658)3.45345114
12Gastrointestinal infarctions (HP:0005244)3.34431323
13Prolonged bleeding time (HP:0003010)3.29358972
14Obstructive lung disease (HP:0006536)3.24491269
15Chronic obstructive pulmonary disease (HP:0006510)3.24491269
16Agammaglobulinemia (HP:0004432)3.23744150
17Orchitis (HP:0100796)3.23559537
18Elevated erythrocyte sedimentation rate (HP:0003565)3.22913223
19Colitis (HP:0002583)3.22718995
20Gastrointestinal inflammation (HP:0004386)3.20122452
21Recurrent gram-negative bacterial infections (HP:0005420)3.19304305
22Recurrent viral infections (HP:0004429)3.18723523
23Vasculitis (HP:0002633)3.02460906
24Panhypogammaglobulinemia (HP:0003139)3.02299171
25Retrobulbar optic neuritis (HP:0100654)3.00544188
26Optic neuritis (HP:0100653)3.00544188
27Inflammation of the large intestine (HP:0002037)2.98150678
28Spontaneous hematomas (HP:0007420)2.85900910
29Pustule (HP:0200039)2.79923253
30Recurrent skin infections (HP:0001581)2.79918544
31Recurrent cutaneous fungal infections (HP:0011370)2.79659197
32Chronic mucocutaneous candidiasis (HP:0002728)2.79659197
33Gingivitis (HP:0000230)2.77860921
34Gastrointestinal stroma tumor (HP:0100723)2.75359663
35Abnormality of the fingertips (HP:0001211)2.69816547
36Epistaxis (HP:0000421)2.63555085
37Stomatitis (HP:0010280)2.58122885
38Petechiae (HP:0000967)2.57619440
39Encephalitis (HP:0002383)2.55891502
40Chest pain (HP:0100749)2.49829776
41Lymphopenia (HP:0001888)2.47319385
42Pulmonary infiltrates (HP:0002113)2.44122357
43Abnormality of cells of the lymphoid lineage (HP:0012140)2.37367327
44Obstructive sleep apnea (HP:0002870)2.35236643
45Osteomyelitis (HP:0002754)2.34523856
46Emphysema (HP:0002097)2.30360890
47Papilloma (HP:0012740)2.27813855
48Verrucae (HP:0200043)2.27813855
49Urticaria (HP:0001025)2.27496059
50Hemoptysis (HP:0002105)2.24640043
51Hypochromic anemia (HP:0001931)2.23938304
52Granulocytopenia (HP:0001913)2.21166247
53Keratoconjunctivitis sicca (HP:0001097)2.19878902
54Polycythemia (HP:0001901)2.19034966
55Viral hepatitis (HP:0006562)2.17310626
56Polygenic inheritance (HP:0010982)2.15719206
57Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.14647717
58Abnormality of T cells (HP:0002843)2.14553943
59Restrictive lung disease (HP:0002091)2.10762567
60Abnormality of T cell physiology (HP:0011840)2.10225708
61Abnormality of the peritoneum (HP:0002585)2.09501353
62Thrombocytosis (HP:0001894)2.07270474
63Arterial thrombosis (HP:0004420)2.06757494
64Deep palmar crease (HP:0006191)2.06709198
65Dysostosis multiplex (HP:0000943)2.05075700
66Hypergammaglobulinemia (HP:0010702)2.04302071
67Autoimmune hemolytic anemia (HP:0001890)2.03856024
68Thoracic kyphosis (HP:0002942)2.03569385
69Thin bony cortex (HP:0002753)2.03173095
70Pulmonary embolism (HP:0002204)2.01274960
71Impaired platelet aggregation (HP:0003540)2.00144511
72Abnormal platelet function (HP:0011869)2.00144511
73Sepsis (HP:0100806)1.98934776
74T lymphocytopenia (HP:0005403)1.97985246
75Peritonitis (HP:0002586)1.96399906
76Leukocytosis (HP:0001974)1.96139120
77Increased serum ferritin (HP:0003281)1.94798661
78Gingival bleeding (HP:0000225)1.94595657
79Skin ulcer (HP:0200042)1.93426193
80Broad face (HP:0000283)1.92196930
81Abnormality of the thoracic spine (HP:0100711)1.91779850
82Interstitial pulmonary disease (HP:0006530)1.90492456
83Slow saccadic eye movements (HP:0000514)1.90016853
84Fatigue (HP:0012378)1.89889861
85Papilledema (HP:0001085)1.89477439
86Abnormality of T cell number (HP:0011839)1.88886936
87Recurrent bronchitis (HP:0002837)1.88841219
88Increased IgM level (HP:0003496)1.88664830
89Hypertensive crisis (HP:0100735)1.86871321
90Segmental peripheral demyelination/remyelination (HP:0003481)1.85344125
91Keratoconjunctivitis (HP:0001096)1.84546114
92Hemorrhage of the eye (HP:0011885)1.83046556
93Autoimmune thrombocytopenia (HP:0001973)1.82682094
94Recurrent lower respiratory tract infections (HP:0002783)1.81932382
95Malnutrition (HP:0004395)1.80820204
96Seborrheic dermatitis (HP:0001051)1.77736159
97Increased cerebral lipofuscin (HP:0011813)1.77435617
98Purpura (HP:0000979)1.76357827
99Abnormality of the pleura (HP:0002103)1.75529744
100Premature loss of primary teeth (HP:0006323)1.69132622

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PRPF4B3.81594686
2MAP4K13.74730912
3ERN13.59959656
4RIPK43.13177730
5TRIB33.04018023
6CDK122.69877953
7MAP3K132.35286399
8MAP2K32.20088680
9TYK22.14879945
10SMG12.02831536
11MAP3K142.00616930
12IRAK41.95690540
13MAP3K101.92626695
14SIK11.90576948
15BLK1.81966890
16SIK21.71635141
17FGFR41.69595081
18TBK11.69390857
19ZAP701.68601179
20JAK31.65228794
21CSK1.57614684
22TNK21.54734705
23BTK1.51648283
24FES1.51479875
25SIK31.49727755
26EEF2K1.48866000
27IKBKE1.38187838
28GRK61.32852689
29EPHB11.25817976
30MARK21.25093644
31CDC42BPA1.18037841
32IRAK31.16216339
33SYK1.16139957
34JAK11.13337776
35CSF1R1.12777401
36HCK1.11832630
37MAP3K11.10285958
38MAP3K31.09973481
39KIT1.09619728
40MAP3K111.06577751
41MAP3K71.05471483
42ITK1.04640546
43FGFR31.01619742
44IKBKB1.01499881
45TXK1.01450248
46TAOK10.96910678
47PRKD20.95892107
48ICK0.95631753
49RIPK10.93408126
50LCK0.92423338
51PKN20.88688288
52TAOK20.87523079
53HIPK20.86625746
54CDK40.86622615
55MARK30.84977012
56MAPK120.84697766
57FGR0.84058736
58LYN0.83836891
59JAK20.82754353
60MATK0.81265043
61RPS6KC10.79990178
62RPS6KL10.79990178
63PTK60.79900137
64PDPK10.79302454
65PDK10.78765166
66TEC0.76463025
67BRD40.75123079
68MAPK70.71109216
69IRAK20.69064658
70IRAK10.65086546
71STK100.64454227
72TTN0.64373449
73LRRK20.64278836
74CHUK0.62606724
75MTOR0.62477768
76RPS6KA60.62131291
77NME20.61584006
78DYRK1B0.61532314
79PASK0.61178628
80CDK60.59992434
81RPS6KA20.58445095
82MAPK110.56114837
83PIM10.54043949
84KSR20.51169215
85PRKCQ0.50441061
86BMX0.49550585
87MAPK40.48360241
88MAP3K60.45744228
89TYRO30.45702743
90MAP2K20.45170933
91PDGFRA0.43299430
92CAMKK10.42642847
93TAOK30.41264798
94MAPKAPK20.41058597
95RET0.40156077
96MAP2K60.38885306
97PRKCH0.38655058
98RPS6KA10.38115390
99YES10.37406534
100BMPR20.36802939

Predicted pathways (KEGG)

RankGene SetZ-score
1B cell receptor signaling pathway_Homo sapiens_hsa046622.53406073
2Leishmaniasis_Homo sapiens_hsa051402.41431240
3Osteoclast differentiation_Homo sapiens_hsa043802.32589858
4Other glycan degradation_Homo sapiens_hsa005112.31481765
5Primary immunodeficiency_Homo sapiens_hsa053402.18138127
6Allograft rejection_Homo sapiens_hsa053302.17093765
7Acute myeloid leukemia_Homo sapiens_hsa052212.17055089
8Graft-versus-host disease_Homo sapiens_hsa053322.04333291
9Autoimmune thyroid disease_Homo sapiens_hsa053202.00832775
10Staphylococcus aureus infection_Homo sapiens_hsa051501.87132629
11NF-kappa B signaling pathway_Homo sapiens_hsa040641.81927485
12Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.76759129
13Toll-like receptor signaling pathway_Homo sapiens_hsa046201.76586207
14T cell receptor signaling pathway_Homo sapiens_hsa046601.72721201
15Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.69154395
16Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.67245992
17Intestinal immune network for IgA production_Homo sapiens_hsa046721.64310381
18Influenza A_Homo sapiens_hsa051641.58248943
19Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.57147224
20Tuberculosis_Homo sapiens_hsa051521.55744974
21Toxoplasmosis_Homo sapiens_hsa051451.54478900
22Chronic myeloid leukemia_Homo sapiens_hsa052201.54299013
23Measles_Homo sapiens_hsa051621.53836135
24Herpes simplex infection_Homo sapiens_hsa051681.53434576
25TNF signaling pathway_Homo sapiens_hsa046681.51630012
26Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.47924381
27RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.47284802
28Non-small cell lung cancer_Homo sapiens_hsa052231.46868982
29Asthma_Homo sapiens_hsa053101.43972155
30Type I diabetes mellitus_Homo sapiens_hsa049401.43871726
31Antigen processing and presentation_Homo sapiens_hsa046121.40788680
32NOD-like receptor signaling pathway_Homo sapiens_hsa046211.40072262
33Notch signaling pathway_Homo sapiens_hsa043301.38121348
34Viral myocarditis_Homo sapiens_hsa054161.37703299
35Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.34174067
36Hematopoietic cell lineage_Homo sapiens_hsa046401.32496209
37Hepatitis B_Homo sapiens_hsa051611.31730848
38VEGF signaling pathway_Homo sapiens_hsa043701.30757264
39AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.23544046
40Pancreatic cancer_Homo sapiens_hsa052121.21325715
41Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.20930193
42Chemokine signaling pathway_Homo sapiens_hsa040621.19609919
43Malaria_Homo sapiens_hsa051441.18375697
44Jak-STAT signaling pathway_Homo sapiens_hsa046301.17352573
45Hepatitis C_Homo sapiens_hsa051601.14542915
46Neurotrophin signaling pathway_Homo sapiens_hsa047221.10685273
47Leukocyte transendothelial migration_Homo sapiens_hsa046701.06140979
48Apoptosis_Homo sapiens_hsa042101.04851928
49mTOR signaling pathway_Homo sapiens_hsa041501.01469535
50Platelet activation_Homo sapiens_hsa046111.00105136
51Prolactin signaling pathway_Homo sapiens_hsa049170.98847018
52African trypanosomiasis_Homo sapiens_hsa051430.97612995
53HTLV-I infection_Homo sapiens_hsa051660.91629117
54Epstein-Barr virus infection_Homo sapiens_hsa051690.91200284
55Renal cell carcinoma_Homo sapiens_hsa052110.90655964
56Legionellosis_Homo sapiens_hsa051340.90368326
57Pertussis_Homo sapiens_hsa051330.89372835
58Phospholipase D signaling pathway_Homo sapiens_hsa040720.88336016
59Phosphatidylinositol signaling system_Homo sapiens_hsa040700.87402259
60Choline metabolism in cancer_Homo sapiens_hsa052310.86927478
61Endometrial cancer_Homo sapiens_hsa052130.82549139
62Shigellosis_Homo sapiens_hsa051310.81708161
63Viral carcinogenesis_Homo sapiens_hsa052030.81356224
64Adipocytokine signaling pathway_Homo sapiens_hsa049200.80382538
65GnRH signaling pathway_Homo sapiens_hsa049120.77802079
66Salmonella infection_Homo sapiens_hsa051320.77601666
67Insulin resistance_Homo sapiens_hsa049310.77184967
68Rheumatoid arthritis_Homo sapiens_hsa053230.74153653
69ErbB signaling pathway_Homo sapiens_hsa040120.73494948
70Amoebiasis_Homo sapiens_hsa051460.73394713
71Colorectal cancer_Homo sapiens_hsa052100.71941366
72Bladder cancer_Homo sapiens_hsa052190.71829624
73Inositol phosphate metabolism_Homo sapiens_hsa005620.71707666
74Prostate cancer_Homo sapiens_hsa052150.71337065
75Transcriptional misregulation in cancer_Homo sapiens_hsa052020.70261905
76Glycosaminoglycan degradation_Homo sapiens_hsa005310.69918702
77Sphingolipid signaling pathway_Homo sapiens_hsa040710.67729635
78HIF-1 signaling pathway_Homo sapiens_hsa040660.67160604
79FoxO signaling pathway_Homo sapiens_hsa040680.66447230
80Phagosome_Homo sapiens_hsa041450.65102796
81Longevity regulating pathway - mammal_Homo sapiens_hsa042110.64333624
82Carbohydrate digestion and absorption_Homo sapiens_hsa049730.63560447
83Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.62427874
84Small cell lung cancer_Homo sapiens_hsa052220.61790889
85Lysosome_Homo sapiens_hsa041420.61111736
86MAPK signaling pathway_Homo sapiens_hsa040100.60948890
87Insulin signaling pathway_Homo sapiens_hsa049100.59292053
88Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.58991009
89Endocytosis_Homo sapiens_hsa041440.58857257
90Glycerophospholipid metabolism_Homo sapiens_hsa005640.58137119
91Prion diseases_Homo sapiens_hsa050200.54681110
92Central carbon metabolism in cancer_Homo sapiens_hsa052300.54139625
93Glioma_Homo sapiens_hsa052140.54008075
94Thyroid hormone signaling pathway_Homo sapiens_hsa049190.53791760
95Estrogen signaling pathway_Homo sapiens_hsa049150.53748324
96Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.51718253
97Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.51651164
98Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.50235274
99Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.48996246
100Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.48141789

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