AKAP10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the A-kinase anchor protein family. A-kinase anchor proteins bind to the regulatory subunits of protein kinase A (PKA) and confine the holoenzyme to discrete locations within the cell. The encoded protein is localized to mitochondria and interacts with both the type I and type II regulatory subunits of PKA. Polymorphisms in this gene may be associated with increased risk of arrhythmias and sudden cardiac death. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of B cell receptor signaling pathway (GO:0050855)5.59026826
2axon ensheathment in central nervous system (GO:0032291)5.37558963
3central nervous system myelination (GO:0022010)5.37558963
4positive regulation of gamma-delta T cell activation (GO:0046645)5.27060178
5cellular extravasation (GO:0045123)4.94473612
6neutrophil mediated immunity (GO:0002446)4.38710124
7antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.27824965
8negative T cell selection (GO:0043383)4.20455710
9negative thymic T cell selection (GO:0045060)4.09639855
10regulation of cell maturation (GO:1903429)4.08020839
11histone H3-K4 trimethylation (GO:0080182)4.07065945
12long-chain fatty acid biosynthetic process (GO:0042759)4.00815674
13positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.96049487
14presynaptic membrane assembly (GO:0097105)3.95348271
15myeloid leukocyte mediated immunity (GO:0002444)3.93720753
16positive regulation by organism of defense response of other organism involved in symbiotic interact3.91014938
17modulation by symbiont of host immune response (GO:0052553)3.91014938
18positive regulation by symbiont of host defense response (GO:0052509)3.91014938
19modulation by symbiont of host defense response (GO:0052031)3.91014938
20modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.91014938
21modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.91014938
22neural tube formation (GO:0001841)3.88654630
23positive T cell selection (GO:0043368)3.79312547
24presynaptic membrane organization (GO:0097090)3.76275067
25neuron cell-cell adhesion (GO:0007158)3.74253542
26negative regulation of interleukin-12 production (GO:0032695)3.67431596
27response to interleukin-15 (GO:0070672)3.66582087
28phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.58474484
29interleukin-6-mediated signaling pathway (GO:0070102)3.58024653
30positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.54324512
31neutrophil activation (GO:0042119)3.49947830
32glycerophospholipid catabolic process (GO:0046475)3.49641194
33histone-serine phosphorylation (GO:0035404)3.48959623
34detection of molecule of bacterial origin (GO:0032490)3.48069947
35positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.40547798
36negative regulation of lymphocyte mediated immunity (GO:0002707)3.40458435
37macrophage activation involved in immune response (GO:0002281)3.34037180
38regulation of gamma-delta T cell activation (GO:0046643)3.32215289
39detection of other organism (GO:0098543)3.30733293
40establishment of protein localization to mitochondrial membrane (GO:0090151)3.25651308
41mannosylation (GO:0097502)3.25350424
42activated T cell proliferation (GO:0050798)3.24467004
43positive regulation of granulocyte differentiation (GO:0030854)3.23853208
44interferon-gamma production (GO:0032609)3.22552980
45respiratory burst (GO:0045730)3.22342072
46macrophage activation (GO:0042116)3.19615157
47protein K11-linked deubiquitination (GO:0035871)3.15940536
48granulocyte activation (GO:0036230)3.15299785
49positive regulation of protein homodimerization activity (GO:0090073)3.14555203
50cellular response to ethanol (GO:0071361)3.12327935
51positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968)3.11116087
52B cell receptor signaling pathway (GO:0050853)3.09722688
53antigen processing and presentation of endogenous antigen (GO:0019883)3.09554494
54myeloid cell activation involved in immune response (GO:0002275)3.08766081
55positive regulation of synapse assembly (GO:0051965)3.08160159
56positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.06599385
57regulation of tolerance induction (GO:0002643)3.05763241
58leukocyte aggregation (GO:0070486)3.04102039
59gamma-aminobutyric acid signaling pathway (GO:0007214)3.03731646
60detection of external biotic stimulus (GO:0098581)3.02140945
61T cell selection (GO:0045058)2.99848341
62peptidyl-lysine trimethylation (GO:0018023)2.99358720
63developmental pigmentation (GO:0048066)2.98496073
64positive thymic T cell selection (GO:0045059)2.97558570
65regulation of T cell tolerance induction (GO:0002664)2.97374525
66antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.96703741
67regulation of alpha-beta T cell proliferation (GO:0046640)2.96621020
68negative regulation of neurotransmitter transport (GO:0051589)2.95859339
69regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.94700421
70dopamine biosynthetic process (GO:0042416)2.94678040
71response to host immune response (GO:0052572)2.90620363
72response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.90620363
73regulation of B cell differentiation (GO:0045577)2.88599398
74negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.87999794
75T cell migration (GO:0072678)2.87019076
76chaperone-mediated protein transport (GO:0072321)2.86729282
77detection of bacterium (GO:0016045)2.86091800
78dendritic cell migration (GO:0036336)2.85692322
79response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.82367038
80response to host (GO:0075136)2.82367038
81response to host defenses (GO:0052200)2.82367038
82fatty acid elongation (GO:0030497)2.81471133
83myelination (GO:0042552)2.80945328
84regulation of interferon-beta biosynthetic process (GO:0045357)2.80712239
85GPI anchor metabolic process (GO:0006505)2.78401326
86positive regulation of histone H3-K4 methylation (GO:0051571)2.78109740
87RNA destabilization (GO:0050779)2.77516884
88response to peptidoglycan (GO:0032494)2.76983768
89protein localization to cilium (GO:0061512)2.76302038
90positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.75723702
91regulation of interleukin-6 biosynthetic process (GO:0045408)2.75650818
92positive regulation of tolerance induction (GO:0002645)2.75569860
93regulation of pigment cell differentiation (GO:0050932)2.73434123
94regulation of gamma-delta T cell differentiation (GO:0045586)2.72435939
95GPI anchor biosynthetic process (GO:0006506)2.72213918
96deoxyribonucleoside diphosphate metabolic process (GO:0009186)2.72163644
97ensheathment of neurons (GO:0007272)2.72034763
98axon ensheathment (GO:0008366)2.72034763
99tyrosine phosphorylation of STAT protein (GO:0007260)2.71548453
100mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.71347309
101superoxide anion generation (GO:0042554)2.70104024
102negative regulation of leukocyte mediated immunity (GO:0002704)2.70056659
103hepatocyte apoptotic process (GO:0097284)2.70017213
104positive regulation of mast cell activation (GO:0033005)2.68987189
105tolerance induction (GO:0002507)2.67969405
106dopamine transport (GO:0015872)2.67237640
107regulation of isotype switching to IgG isotypes (GO:0048302)2.67149062
108leukocyte migration involved in inflammatory response (GO:0002523)2.66486540
109neurotransmitter uptake (GO:0001504)2.66427956
110antigen receptor-mediated signaling pathway (GO:0050851)2.65671021
111negative regulation of adaptive immune response (GO:0002820)2.64414437
112regulation of T cell mediated cytotoxicity (GO:0001914)2.61843049
113T cell proliferation (GO:0042098)2.61311817
114purinergic nucleotide receptor signaling pathway (GO:0035590)2.61023686
115epithelial cilium movement (GO:0003351)2.61023124
116histone H2B ubiquitination (GO:0033523)2.59989463
117lymphoid progenitor cell differentiation (GO:0002320)2.58978106
118regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.58071659
119production of molecular mediator involved in inflammatory response (GO:0002532)2.57062507
120negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.56755757
121positive regulation of DNA recombination (GO:0045911)2.56532483
122positive regulation of isotype switching (GO:0045830)2.55950712
123ribosomal small subunit biogenesis (GO:0042274)2.55520012
124regulation of catecholamine metabolic process (GO:0042069)2.54893145
125regulation of dopamine metabolic process (GO:0042053)2.54893145
126vitamin catabolic process (GO:0009111)2.54409783
127fat-soluble vitamin catabolic process (GO:0042363)2.54409783
128cilium movement (GO:0003341)2.54105055
129transmission of nerve impulse (GO:0019226)2.51542246
130negative regulation of synaptic transmission, GABAergic (GO:0032229)2.49626875
131preassembly of GPI anchor in ER membrane (GO:0016254)2.48739876
132protein localization to synapse (GO:0035418)2.48309738
133microtubule polymerization or depolymerization (GO:0031109)2.47236370
134oligodendrocyte differentiation (GO:0048709)2.46880850
135regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.46532457
136mast cell activation (GO:0045576)2.46459899
137negative regulation of exocytosis (GO:0045920)2.43512355
138nonmotile primary cilium assembly (GO:0035058)2.43470747
139negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.43199230
140natural killer cell activation involved in immune response (GO:0002323)2.42305222
141L-amino acid import (GO:0043092)2.40660365
142cerebral cortex radially oriented cell migration (GO:0021799)2.40613188
143negative regulation of execution phase of apoptosis (GO:1900118)2.40021390
144protein neddylation (GO:0045116)2.38583661
145neuron remodeling (GO:0016322)2.36682361
146ionotropic glutamate receptor signaling pathway (GO:0035235)2.36233856
147regulation of activation of Janus kinase activity (GO:0010533)2.36044654
148leukocyte degranulation (GO:0043299)2.35829808
149positive regulation of T cell cytokine production (GO:0002726)2.30942724
150postsynaptic membrane organization (GO:0001941)2.30590021
151spermatid nucleus differentiation (GO:0007289)2.29714308
152glutamate receptor signaling pathway (GO:0007215)2.29306111
153mast cell activation involved in immune response (GO:0002279)2.28561092
154mast cell degranulation (GO:0043303)2.28561092
155microtubule depolymerization (GO:0007019)2.27509329
156regulation of mast cell activation (GO:0033003)2.26379621
157neuron recognition (GO:0008038)2.25888059
158negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.25053009
159negative regulation of cell killing (GO:0031342)2.25053009
160regulation of feeding behavior (GO:0060259)2.24263401
161regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.23267315
162negative regulation of neurotransmitter secretion (GO:0046929)2.22968227
163positive regulation of oligodendrocyte differentiation (GO:0048714)2.21133950
164cell fate commitment involved in formation of primary germ layer (GO:0060795)2.20795363
165regulation of timing of cell differentiation (GO:0048505)2.16902702
166regulation of T cell cytokine production (GO:0002724)2.16521745
167serotonin receptor signaling pathway (GO:0007210)2.15667886
168regulation of collateral sprouting (GO:0048670)2.14967021
169microglial cell activation (GO:0001774)2.12481543
170regulation of histone H3-K27 methylation (GO:0061085)2.12215185
171neutrophil activation involved in immune response (GO:0002283)2.11881255
172regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.10558499
173cellular response to interleukin-15 (GO:0071350)2.10420339
174centriole replication (GO:0007099)2.10285789
175limb bud formation (GO:0060174)2.10023008
176regulation of mast cell degranulation (GO:0043304)2.09646609
177glycolipid biosynthetic process (GO:0009247)2.09430945
178cellular response to gamma radiation (GO:0071480)2.09298087
179GTP biosynthetic process (GO:0006183)2.08974095
180positive regulation of interleukin-17 production (GO:0032740)2.08538406
181negative regulation of T cell mediated immunity (GO:0002710)2.08355997
182ATP synthesis coupled proton transport (GO:0015986)2.07235932
183energy coupled proton transport, down electrochemical gradient (GO:0015985)2.07235932
184fusion of sperm to egg plasma membrane (GO:0007342)2.06712650
185C-terminal protein amino acid modification (GO:0018410)2.06382594

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse4.42893247
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.41552911
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.80842670
4EZH2_22144423_ChIP-Seq_EOC_Human3.71717230
5GBX2_23144817_ChIP-Seq_PC3_Human3.49420825
6TAF15_26573619_Chip-Seq_HEK293_Human2.74955892
7SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.72573600
8POU3F2_20337985_ChIP-ChIP_501MEL_Human2.68660235
9ZFP57_27257070_Chip-Seq_ESCs_Mouse2.64556068
10TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.62081109
11VDR_22108803_ChIP-Seq_LS180_Human2.60860144
12RUNX_20019798_ChIP-Seq_JUKART_Human2.58181487
13IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.57245202
14SCL_19346495_ChIP-Seq_HPC-7_Human2.53335065
15STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.52981991
16SALL1_21062744_ChIP-ChIP_HESCs_Human2.49552311
17GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.42419988
18FLI1_27457419_Chip-Seq_LIVER_Mouse2.33714542
19* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.32450997
20PCGF2_27294783_Chip-Seq_ESCs_Mouse2.28896060
21MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.27959539
22IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.27294341
23BP1_19119308_ChIP-ChIP_Hs578T_Human2.25349405
24FUS_26573619_Chip-Seq_HEK293_Human2.24712027
25IRF8_27001747_Chip-Seq_BMDM_Mouse2.22316006
26CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.18742490
27CTBP1_25329375_ChIP-Seq_LNCAP_Human2.08045211
28ER_23166858_ChIP-Seq_MCF-7_Human2.05373597
29IGF1R_20145208_ChIP-Seq_DFB_Human1.97298339
30CTBP2_25329375_ChIP-Seq_LNCAP_Human1.95896372
31BMI1_23680149_ChIP-Seq_NPCS_Mouse1.95673978
32MYB_26560356_Chip-Seq_TH2_Human1.93575466
33NANOG_18555785_Chip-Seq_ESCs_Mouse1.92501277
34TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.91584023
35ZNF274_21170338_ChIP-Seq_K562_Hela1.90528722
36FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.86179981
37Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.81077987
38SUZ12_27294783_Chip-Seq_NPCs_Mouse1.80258590
39MYB_21317192_ChIP-Seq_ERMYB_Mouse1.80172077
40E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.79987646
41P300_19829295_ChIP-Seq_ESCs_Human1.77901332
42* CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.77883978
43EWS_26573619_Chip-Seq_HEK293_Human1.76941441
44HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.76417347
45GATA1_22025678_ChIP-Seq_K562_Human1.76331237
46SMAD_19615063_ChIP-ChIP_OVARY_Human1.76268667
47SUZ12_18555785_Chip-Seq_ESCs_Mouse1.70395787
48EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.70064183
49PCGF2_27294783_Chip-Seq_NPCs_Mouse1.69860252
50MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.69765259
51* SPI1_23547873_ChIP-Seq_NB4_Human1.67879616
52CBX2_27304074_Chip-Seq_ESCs_Mouse1.67829434
53FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.66743938
54NFE2_27457419_Chip-Seq_LIVER_Mouse1.66383630
55E2F1_18555785_Chip-Seq_ESCs_Mouse1.65040625
56P300_18555785_Chip-Seq_ESCs_Mouse1.64635953
57ELF1_17652178_ChIP-ChIP_JURKAT_Human1.62529512
58GATA3_27048872_Chip-Seq_THYMUS_Human1.61280782
59CMYC_18555785_Chip-Seq_ESCs_Mouse1.61232093
60VDR_24787735_ChIP-Seq_THP-1_Human1.60391271
61STAT3_18555785_Chip-Seq_ESCs_Mouse1.59977759
62JARID2_20064375_ChIP-Seq_MESCs_Mouse1.58345766
63GATA3_26560356_Chip-Seq_TH2_Human1.58144086
64SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.58063705
65SMAD3_21741376_ChIP-Seq_EPCs_Human1.56959199
66EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.56210035
67RNF2_27304074_Chip-Seq_NSC_Mouse1.55955916
68RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.54745904
69EZH2_27294783_Chip-Seq_NPCs_Mouse1.54745403
70SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.54679743
71P53_22387025_ChIP-Seq_ESCs_Mouse1.53248516
72* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.52694586
73PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.50850001
74SPI1_23127762_ChIP-Seq_K562_Human1.50571638
75* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.48590194
76SMAD4_21799915_ChIP-Seq_A2780_Human1.46424476
77NMYC_18555785_Chip-Seq_ESCs_Mouse1.45742520
78TOP2B_26459242_ChIP-Seq_MCF-7_Human1.44698395
79RUNX1_27457419_Chip-Seq_LIVER_Mouse1.44027127
80MYB_26560356_Chip-Seq_TH1_Human1.43309586
81SOX2_18555785_Chip-Seq_ESCs_Mouse1.41937354
82KLF4_18555785_Chip-Seq_ESCs_Mouse1.40368604
83UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.40114059
84OCT4_18555785_Chip-Seq_ESCs_Mouse1.39134451
85SMAD1_18555785_Chip-Seq_ESCs_Mouse1.38279140
86OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.37513832
87TAL1_26923725_Chip-Seq_HPCs_Mouse1.37245877
88PIAS1_25552417_ChIP-Seq_VCAP_Human1.36353570
89POU5F1_16153702_ChIP-ChIP_HESCs_Human1.35775099
90* FLI1_21867929_ChIP-Seq_TH2_Mouse1.35745306
91SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.34816007
92ZFX_18555785_Chip-Seq_ESCs_Mouse1.33729472
93PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.31557834
94VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.27588695
95NOTCH1_21737748_ChIP-Seq_TLL_Human1.27194869
96FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.26819735
97AR_21572438_ChIP-Seq_LNCaP_Human1.26184149
98MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.26119288
99CTCF_18555785_Chip-Seq_ESCs_Mouse1.25976197
100ESRRB_18555785_Chip-Seq_ESCs_Mouse1.25737500
101* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.25106853
102BCAT_22108803_ChIP-Seq_LS180_Human1.24820646
103PU1_27457419_Chip-Seq_LIVER_Mouse1.19043416
104IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.18898890
105CBP_20019798_ChIP-Seq_JUKART_Human1.18898890
106TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18474271
107POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.18474271
108EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.17236182
109RUNX2_22187159_ChIP-Seq_PCA_Human1.16635283
110PRDM14_20953172_ChIP-Seq_ESCs_Human1.15684349
111TCF4_23295773_ChIP-Seq_U87_Human1.15537195
112* KDM2B_26808549_Chip-Seq_REH_Human1.15179983
113* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.13814372
114EZH2_27304074_Chip-Seq_ESCs_Mouse1.12327201
115* TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.11300316
116SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.11072574
117PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.10792619
118IRF1_19129219_ChIP-ChIP_H3396_Human1.09901080
119SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.09570470
120GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.09250650
121* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.08764571
122IRF8_21731497_ChIP-ChIP_J774_Mouse1.08617080
123* CRX_20693478_ChIP-Seq_RETINA_Mouse1.07989109
124* TP53_16413492_ChIP-PET_HCT116_Human1.07207408
125EED_16625203_ChIP-ChIP_MESCs_Mouse1.06520262
126AR_25329375_ChIP-Seq_VCAP_Human1.05853982
127RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.04833416
128CDX2_19796622_ChIP-Seq_MESCs_Mouse1.03873738
129JUN_21703547_ChIP-Seq_K562_Human1.03315852
130OCT4_21477851_ChIP-Seq_ESCs_Mouse1.02953189
131SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.02637120
132TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.02183995
133SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.01910982
134* PU_27001747_Chip-Seq_BMDM_Mouse1.01099505
135* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00855633
136REST_21632747_ChIP-Seq_MESCs_Mouse1.00430535
137ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.00167219
138FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.99932493
139TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98180592
140FOXM1_26456572_ChIP-Seq_MCF-7_Human0.96424584
141MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.96398065
142PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.96355602
143SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.96287811
144HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.95901873
145RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.95582266
146RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.95292842
147STAT3_23295773_ChIP-Seq_U87_Human0.95229962
148CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.95133369
149SMRT_27268052_Chip-Seq_Bcells_Human0.94470782
150STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.93800239
151NRF2_20460467_ChIP-Seq_MEFs_Mouse0.92723690
152NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.92723690
153TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.91554870
154LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.90954806
155AHR_22903824_ChIP-Seq_MCF-7_Human0.90014011
156MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.89527379
157SALL4_22934838_ChIP-ChIP_CD34+_Human0.89312113

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation7.22342266
2MP0003880_abnormal_central_pattern4.30783080
3MP0005409_darkened_coat_color3.18606359
4MP0002009_preneoplasia3.04497778
5MP0003136_yellow_coat_color2.85749843
6MP0005171_absent_coat_pigmentation2.67227576
7MP0003763_abnormal_thymus_physiology2.50549268
8MP0006292_abnormal_olfactory_placode2.47068844
9MP0003436_decreased_susceptibility_to2.30672970
10MP0004742_abnormal_vestibular_system2.20166909
11MP0001905_abnormal_dopamine_level2.07183120
12MP0000920_abnormal_myelination2.06654501
13MP0006082_CNS_inflammation1.98714180
14MP0000685_abnormal_immune_system1.96013058
15MP0008057_abnormal_DNA_replication1.95877231
16MP0005464_abnormal_platelet_physiology1.91380619
17MP0001188_hyperpigmentation1.90212411
18MP0001486_abnormal_startle_reflex1.90161717
19MP0005423_abnormal_somatic_nervous1.88864897
20MP0004381_abnormal_hair_follicle1.88280956
21MP0001529_abnormal_vocalization1.81574559
22MP0009745_abnormal_behavioral_response1.77459064
23MP0005410_abnormal_fertilization1.77212851
24* MP0006276_abnormal_autonomic_nervous1.77167548
25MP0003300_gastrointestinal_ulcer1.75312656
26MP0002405_respiratory_system_inflammati1.74311109
27MP0004270_analgesia1.73747789
28MP0002398_abnormal_bone_marrow1.72924713
29MP0002102_abnormal_ear_morphology1.72266701
30MP0002064_seizures1.71604288
31MP0001440_abnormal_grooming_behavior1.69978600
32MP0000015_abnormal_ear_pigmentation1.69942805
33MP0004142_abnormal_muscle_tone1.67778732
34MP0005174_abnormal_tail_pigmentation1.67176372
35MP0000371_diluted_coat_color1.66838780
36MP0000716_abnormal_immune_system1.65727871
37MP0002272_abnormal_nervous_system1.65176761
38MP0003303_peritoneal_inflammation1.64792978
39MP0002572_abnormal_emotion/affect_behav1.64622213
40MP0009379_abnormal_foot_pigmentation1.64296566
41MP0003172_abnormal_lysosome_physiology1.62237410
42MP0002928_abnormal_bile_duct1.61555771
43MP0003635_abnormal_synaptic_transmissio1.61395635
44MP0000372_irregular_coat_pigmentation1.58621245
45MP0005379_endocrine/exocrine_gland_phen1.56064267
46MP0000689_abnormal_spleen_morphology1.52905410
47MP0000703_abnormal_thymus_morphology1.51764821
48MP0001502_abnormal_circadian_rhythm1.51686908
49MP0002736_abnormal_nociception_after1.50901422
50MP0009046_muscle_twitch1.49543219
51MP0001968_abnormal_touch/_nociception1.48249895
52MP0003950_abnormal_plasma_membrane1.47800746
53MP0000778_abnormal_nervous_system1.46295178
54MP0002722_abnormal_immune_system1.44278942
55MP0002063_abnormal_learning/memory/cond1.41633296
56MP0001485_abnormal_pinna_reflex1.41459680
57MP0001986_abnormal_taste_sensitivity1.40632021
58MP0002638_abnormal_pupillary_reflex1.40557598
59MP0003656_abnormal_erythrocyte_physiolo1.33444292
60MP0001533_abnormal_skeleton_physiology1.32903559
61MP0008877_abnormal_DNA_methylation1.31018991
62MP0004883_abnormal_blood_vessel1.30893308
63MP0002938_white_spotting1.30811523
64MP0003866_abnormal_defecation1.29391255
65MP0004859_abnormal_synaptic_plasticity1.28432429
66MP0005000_abnormal_immune_tolerance1.27235163
67MP0000383_abnormal_hair_follicle1.26579567
68MP0005551_abnormal_eye_electrophysiolog1.26011440
69MP0001845_abnormal_inflammatory_respons1.25830005
70MP0003828_pulmonary_edema1.25658754
71MP0009764_decreased_sensitivity_to1.25146675
72MP0001963_abnormal_hearing_physiology1.24908069
73MP0004885_abnormal_endolymph1.24601541
74MP0006054_spinal_hemorrhage1.23805023
75MP0002429_abnormal_blood_cell1.22572696
76MP0002067_abnormal_sensory_capabilities1.22468784
77MP0002396_abnormal_hematopoietic_system1.22095933
78MP0000427_abnormal_hair_cycle1.20213621
79MP0003724_increased_susceptibility_to1.19270985
80MP0002006_tumorigenesis1.18397893
81MP0005387_immune_system_phenotype1.18156431
82MP0001790_abnormal_immune_system1.18156431
83MP0002734_abnormal_mechanical_nocicepti1.17810459
84MP0003938_abnormal_ear_development1.17744700
85MP0003690_abnormal_glial_cell1.17469871
86MP0008961_abnormal_basal_metabolism1.17334015
87MP0005075_abnormal_melanosome_morpholog1.15829541
88MP0003195_calcinosis1.15726575
89MP0005671_abnormal_response_to1.13912622
90MP0002148_abnormal_hypersensitivity_rea1.12835419
91MP0002095_abnormal_skin_pigmentation1.12029077
92MP0001970_abnormal_pain_threshold1.10540179
93MP0002166_altered_tumor_susceptibility1.10426625
94MP0003183_abnormal_peptide_metabolism1.10124818
95MP0002277_abnormal_respiratory_mucosa1.09675733
96MP0001835_abnormal_antigen_presentation1.08043063
97MP0006072_abnormal_retinal_apoptosis1.08016342
98MP0002735_abnormal_chemical_nociception1.07875889
99MP0000465_gastrointestinal_hemorrhage1.05819469
100MP0000566_synostosis1.05308951
101MP0000631_abnormal_neuroendocrine_gland1.04284696
102MP0002419_abnormal_innate_immunity1.03872282
103MP0002184_abnormal_innervation1.03600596
104MP0004947_skin_inflammation1.02294118
105MP0010155_abnormal_intestine_physiology1.02142469
106MP0003698_abnormal_male_reproductive1.01618414
107MP0004808_abnormal_hematopoietic_stem1.01506826
108MP0010678_abnormal_skin_adnexa1.01033090
109MP0000026_abnormal_inner_ear1.00267153
110MP0001800_abnormal_humoral_immune0.99627662
111MP0002998_abnormal_bone_remodeling0.98735485
112MP0003191_abnormal_cellular_cholesterol0.98461803
113MP0005164_abnormal_response_to0.97878740
114MP0009333_abnormal_splenocyte_physiolog0.97808555
115MP0002723_abnormal_immune_serum0.97424856
116MP0002733_abnormal_thermal_nociception0.96454084
117MP0003787_abnormal_imprinting0.94022974
118MP0005025_abnormal_response_to0.92902418
119MP0005377_hearing/vestibular/ear_phenot0.92207130
120MP0003878_abnormal_ear_physiology0.92207130
121MP0008260_abnormal_autophagy0.91044873
122MP0002420_abnormal_adaptive_immunity0.90924472
123MP0001501_abnormal_sleep_pattern0.89913331
124MP0008469_abnormal_protein_level0.89536079
125MP0005646_abnormal_pituitary_gland0.89524676
126MP0009115_abnormal_fat_cell0.89331161
127MP0005310_abnormal_salivary_gland0.89208974
128MP0002882_abnormal_neuron_morphology0.89197565
129MP0001819_abnormal_immune_cell0.88788138
130MP0003634_abnormal_glial_cell0.88267160
131MP0001929_abnormal_gametogenesis0.88125005
132MP0002752_abnormal_somatic_nervous0.87826196
133MP0002557_abnormal_social/conspecific_i0.87696883
134MP0001545_abnormal_hematopoietic_system0.87660204
135MP0005397_hematopoietic_system_phenotyp0.87660204
136MP0005253_abnormal_eye_physiology0.87483706
137MP0002452_abnormal_antigen_presenting0.86990702
138MP0000604_amyloidosis0.85650953
139MP0005645_abnormal_hypothalamus_physiol0.84548681
140MP0003045_fibrosis0.84475373
141MP0004484_altered_response_of0.84104088
142MP0002229_neurodegeneration0.83599025
143MP0009785_altered_susceptibility_to0.83520607
144MP0001851_eye_inflammation0.81332136
145MP0004924_abnormal_behavior0.81037079
146MP0005386_behavior/neurological_phenoty0.81037079
147MP0000462_abnormal_digestive_system0.78511351
148MP0003632_abnormal_nervous_system0.76062208
149MP0002653_abnormal_ependyma_morphology0.74450599
150MP0001919_abnormal_reproductive_system0.74393612
151MP0005408_hypopigmentation0.72266725
152MP0001324_abnormal_eye_pigmentation0.71442491
153MP0003252_abnormal_bile_duct0.68897519
154MP0002075_abnormal_coat/hair_pigmentati0.67781968
155MP0002332_abnormal_exercise_endurance0.66944906
156MP0003121_genomic_imprinting0.65949289
157MP0008007_abnormal_cellular_replicative0.64299997
158MP0004043_abnormal_pH_regulation0.61155410
159MP0003221_abnormal_cardiomyocyte_apopto0.60484008
160MP0005389_reproductive_system_phenotype0.57229200
161MP0000249_abnormal_blood_vessel0.56556620
162MP0002693_abnormal_pancreas_physiology0.55466363
163MP0003795_abnormal_bone_structure0.55365559

Predicted human phenotypes

RankGene SetZ-score
1Recurrent bacterial skin infections (HP:0005406)4.57528592
2Abnormal delayed hypersensitivity skin test (HP:0002963)4.41114802
3Volvulus (HP:0002580)4.07954744
4Eczematoid dermatitis (HP:0000976)4.03848792
5Parakeratosis (HP:0001036)3.75352951
6T lymphocytopenia (HP:0005403)3.74002891
7Abnormality of T cell number (HP:0011839)3.73375016
8Myositis (HP:0100614)3.71350561
9Recurrent fungal infections (HP:0002841)3.68015862
10Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.50794664
11Recurrent gram-negative bacterial infections (HP:0005420)3.49886142
12Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.42351527
13Orchitis (HP:0100796)3.41493250
14Increased hepatocellular lipid droplets (HP:0006565)3.38522063
15Gastrointestinal infarctions (HP:0005244)3.33943896
16Elevated erythrocyte sedimentation rate (HP:0003565)3.33830323
17Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.29090751
18Recurrent skin infections (HP:0001581)3.27512339
19Panhypogammaglobulinemia (HP:0003139)3.25850678
20Abnormality of T cells (HP:0002843)3.23550236
21Degeneration of the lateral corticospinal tracts (HP:0002314)3.17257250
22Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.17257250
23Albinism (HP:0001022)3.15761379
24Dynein arm defect of respiratory motile cilia (HP:0012255)3.15628138
25Absent/shortened dynein arms (HP:0200106)3.15628138
26Abnormality of the renal collecting system (HP:0004742)3.15371709
27Renal Fanconi syndrome (HP:0001994)3.10300256
28Mediastinal lymphadenopathy (HP:0100721)3.06728266
29White forelock (HP:0002211)2.99672133
30Patchy hypopigmentation of hair (HP:0011365)2.98516905
31Encephalitis (HP:0002383)2.86501563
32Eosinophilia (HP:0001880)2.86499315
33Leukocytosis (HP:0001974)2.86451505
34Abnormality of the axillary hair (HP:0100134)2.84570781
35Abnormality of secondary sexual hair (HP:0009888)2.84570781
36Abnormality of T cell physiology (HP:0011840)2.83611983
37Abnormal ciliary motility (HP:0012262)2.82460104
38Sensory axonal neuropathy (HP:0003390)2.80938742
39Duplicated collecting system (HP:0000081)2.74208979
403-Methylglutaconic aciduria (HP:0003535)2.71737132
41Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.71205097
42Meningitis (HP:0001287)2.67884345
43Autoimmune hemolytic anemia (HP:0001890)2.67320784
44Abnormality of macrophages (HP:0004311)2.66545767
45Chest pain (HP:0100749)2.65136977
46Gingivitis (HP:0000230)2.63715471
47Abnormal respiratory motile cilium physiology (HP:0012261)2.60897300
48Abnormality of eosinophils (HP:0001879)2.60625299
49Chromosomal breakage induced by crosslinking agents (HP:0003221)2.60076490
50Abnormal respiratory epithelium morphology (HP:0012253)2.58271321
51Abnormal respiratory motile cilium morphology (HP:0005938)2.58271321
52Abnormal hair whorl (HP:0010721)2.57578909
53Neoplasm of the tracheobronchial system (HP:0100552)2.57014113
54Hypochromic microcytic anemia (HP:0004840)2.56597506
55Spontaneous hematomas (HP:0007420)2.55035456
56Granulocytopenia (HP:0001913)2.53008662
57Pulmonary infiltrates (HP:0002113)2.52132852
58Syringomyelia (HP:0003396)2.51001730
59Spinal cord lesions (HP:0100561)2.51001730
60Keratoconjunctivitis (HP:0001096)2.50393243
61Exertional dyspnea (HP:0002875)2.49991021
62Hypothermia (HP:0002045)2.49388285
63Abnormality of the prostate (HP:0008775)2.47391765
64Overriding aorta (HP:0002623)2.45988386
65Lipid accumulation in hepatocytes (HP:0006561)2.44783507
66Medial flaring of the eyebrow (HP:0010747)2.44716670
67Keratoconjunctivitis sicca (HP:0001097)2.41746333
68Chromsome breakage (HP:0040012)2.40066155
69Abnormality of renal resorption (HP:0011038)2.38274715
70Hemoptysis (HP:0002105)2.35265221
71Widely spaced teeth (HP:0000687)2.35244219
72Pustule (HP:0200039)2.34365266
73Abnormality of the pleura (HP:0002103)2.30482322
74Pancreatic fibrosis (HP:0100732)2.24991776
75Recurrent viral infections (HP:0004429)2.24836729
76Periodontitis (HP:0000704)2.24467751
77Vasculitis (HP:0002633)2.24401371
78Autoimmune thrombocytopenia (HP:0001973)2.21662482
79Cupped ear (HP:0000378)2.21307728
80Congenital ichthyosiform erythroderma (HP:0007431)2.20065031
81Truncal obesity (HP:0001956)2.16918728
82Viral hepatitis (HP:0006562)2.15943793
83Type I transferrin isoform profile (HP:0003642)2.14825551
84Arterial thrombosis (HP:0004420)2.10613893
85Hematochezia (HP:0002573)2.08953755
86Constricted visual fields (HP:0001133)2.06632115
87Ureteral obstruction (HP:0006000)2.04955715
88Ocular albinism (HP:0001107)2.04813660
89Morphological abnormality of the inner ear (HP:0011390)2.03980676
90Rimmed vacuoles (HP:0003805)2.03341452
91Flat cornea (HP:0007720)2.02103148
92Febrile seizures (HP:0002373)2.02009529
93IgG deficiency (HP:0004315)2.00903869
94Inflammation of the large intestine (HP:0002037)2.00364362
95Protruding tongue (HP:0010808)1.99857275
96Urticaria (HP:0001025)1.99366357
97Fair hair (HP:0002286)1.99046875
98Broad-based gait (HP:0002136)1.98062426
99Pancreatic cysts (HP:0001737)1.95885950
100Gait imbalance (HP:0002141)1.95773325
101Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.93779670
102Chronic hepatic failure (HP:0100626)1.93049861
103Increased IgM level (HP:0003496)1.91015593
104Papilledema (HP:0001085)1.90683442
105Stomatitis (HP:0010280)1.90334143
106Pulmonary embolism (HP:0002204)1.90120538
107Peripheral hypomyelination (HP:0007182)1.89925972
108Gingival bleeding (HP:0000225)1.89805225
109Thyroiditis (HP:0100646)1.89446847
110Increased intramyocellular lipid droplets (HP:0012240)1.89426694
111Hypochromic anemia (HP:0001931)1.88535650
112Rhinitis (HP:0012384)1.87880572
113Absent speech (HP:0001344)1.87590798
114Congenital primary aphakia (HP:0007707)1.86310175
115Long clavicles (HP:0000890)1.84858294
116Abnormality of the corticospinal tract (HP:0002492)1.84550197
117True hermaphroditism (HP:0010459)1.83977904
118Nephrogenic diabetes insipidus (HP:0009806)1.83974748
119Gangrene (HP:0100758)1.81553074
120Hip dysplasia (HP:0001385)1.81399196
121Prostate neoplasm (HP:0100787)1.80797998
122Genital tract atresia (HP:0001827)1.79824790
123Epistaxis (HP:0000421)1.79558921
124Attenuation of retinal blood vessels (HP:0007843)1.79096931
125Stomach cancer (HP:0012126)1.78177091
126Chronic diarrhea (HP:0002028)1.77628293
127Insomnia (HP:0100785)1.77327941
128Subacute progressive viral hepatitis (HP:0006572)1.77152678
129Generalized hypopigmentation of hair (HP:0011358)1.77125736
130Vaginal atresia (HP:0000148)1.76863708
131Prolonged bleeding time (HP:0003010)1.76046111
132Progressive inability to walk (HP:0002505)1.75445450
133Mitochondrial inheritance (HP:0001427)1.75205234
134Molar tooth sign on MRI (HP:0002419)1.74406531
135Abnormality of midbrain morphology (HP:0002418)1.74406531
136Spondylolisthesis (HP:0003302)1.73143100
137Obstructive lung disease (HP:0006536)1.73095653
138Chronic obstructive pulmonary disease (HP:0006510)1.73095653
139Elfin facies (HP:0004428)1.72922865
140Alveolar cell carcinoma (HP:0006519)1.72664783
141Prominent nose (HP:0000448)1.72647272
142Abnormality of the diencephalon (HP:0010662)1.71798987
143Retrobulbar optic neuritis (HP:0100654)1.71314283
144Optic neuritis (HP:0100653)1.71314283
145Gastrointestinal inflammation (HP:0004386)1.71285532
146Hyperventilation (HP:0002883)1.71194812
147Generalized hypopigmentation (HP:0007513)1.71005279
148Nephronophthisis (HP:0000090)1.70478750
149Recurrent cutaneous fungal infections (HP:0011370)1.68751697
150Chronic mucocutaneous candidiasis (HP:0002728)1.68751697
151Iris hypopigmentation (HP:0007730)1.65715805
152Ureteral stenosis (HP:0000071)1.64556865
153Recurrent abscess formation (HP:0002722)1.64520635
154Esotropia (HP:0000565)1.64425110
155Blue irides (HP:0000635)1.63699294
156Erythroderma (HP:0001019)1.61590548
157Aplasia/Hypoplasia of the lens (HP:0008063)1.60600602
158Flat occiput (HP:0005469)1.59935618
159Submucous cleft hard palate (HP:0000176)1.59568619
160Reticulocytopenia (HP:0001896)1.59564191
161Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.58820303
162Abnormal protein N-linked glycosylation (HP:0012347)1.58820303
163Abnormal protein glycosylation (HP:0012346)1.58820303
164Abnormal glycosylation (HP:0012345)1.58820303
165Cutaneous melanoma (HP:0012056)1.58677110
166Abnormality of the columella (HP:0009929)1.58331908
167Nasolacrimal duct obstruction (HP:0000579)1.58313731
168Decreased central vision (HP:0007663)1.58106635
169Neurofibrillary tangles (HP:0002185)1.57786344
170Tented upper lip vermilion (HP:0010804)1.57705150
171Aganglionic megacolon (HP:0002251)1.56648757
172Optic disc pallor (HP:0000543)1.56346838
173Aplasia/Hypoplasia of the tibia (HP:0005772)1.55045559
174Anomalous pulmonary venous return (HP:0010772)1.55044689
175Recurrent sinusitis (HP:0011108)1.54407582
176Retinal dysplasia (HP:0007973)1.54153768
177Respiratory difficulties (HP:0002880)1.53599364
178Hypomagnesemia (HP:0002917)1.51983481

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LIMK14.19229399
2MAP3K93.22296714
3FRK3.05279120
4IRAK32.86892764
5PNCK2.79096710
6CASK2.77726124
7IRAK42.69025487
8TNIK2.40815800
9STK392.31761088
10STK162.02819070
11MAP4K21.91656259
12CSK1.89122705
13RIPK41.87168894
14CAMKK21.82336503
15JAK31.81486346
16MARK11.76620023
17FES1.73448856
18PIK3CG1.71041861
19OXSR11.70860824
20IRAK21.67965041
21GRK71.64170394
22TXK1.60590873
23MAP3K121.60333039
24CDC42BPA1.57714217
25ADRBK21.56556853
26IKBKE1.55868112
27BMPR1B1.55136556
28PLK41.53858539
29PKN11.52695712
30JAK11.47725203
31FGR1.47037706
32MUSK1.46375416
33MST41.45440932
34TEC1.35735085
35BMPR21.35239848
36SGK21.34076368
37ZAK1.33899352
38ROCK21.33091115
39MAPKAPK51.31341920
40VRK11.30285868
41SRPK11.29905747
42TYK21.29157097
43AKT31.24808715
44TLK11.24363862
45CSNK1G31.23021888
46EPHA31.21488998
47ZAP701.20489007
48CLK11.19222204
49CSNK1A1L1.17107030
50MKNK21.16344624
51SGK31.13204114
52MAPK131.11053964
53PTK2B1.09601050
54IRAK11.07568698
55JAK21.06066072
56YES11.05551211
57NLK1.05511917
58NEK61.04876141
59NUAK11.04322273
60CSF1R1.00053725
61KSR10.99154097
62BLK0.96895073
63CAMK2B0.96384992
64MAP3K140.95408721
65PBK0.93822410
66CDK190.93107047
67EIF2AK30.88413615
68PRKCH0.87595911
69FGFR30.87416233
70KIT0.86722476
71MATK0.86152200
72MAP3K130.84152957
73CSNK1G10.83172678
74GRK50.82275615
75BRD40.82036918
76NTRK20.81736733
77MKNK10.81479944
78EPHA40.77453410
79RPS6KA50.77241142
80MAP3K20.76962142
81DYRK20.76601753
82TGFBR20.76344244
83PRKCQ0.76320444
84CSNK1G20.76312029
85SYK0.75624360
86STK100.74638652
87CAMK2D0.74145072
88LCK0.73842428
89NTRK30.70062318
90PLK20.69915198
91CDK80.69068992
92PRKCE0.68880304
93STK40.68726613
94CDK30.68394714
95SGK4940.68076491
96SGK2230.68076491
97PIM10.67355763
98DAPK20.66665584
99TAOK30.66403444
100TNK20.65879528
101MAP2K70.64478940
102GRK10.62962431
103MAP2K30.60893422
104LYN0.60794440
105CAMK2A0.59469156
106BCR0.59221842
107CDK60.58266465
108MELK0.56958088
109CDK90.53710599
110CDK120.53236729
111CHEK20.52704573
112FYN0.52224590
113NEK90.51150960
114TBK10.50962374
115EIF2AK20.49757971
116CHUK0.48814371
117ABL10.48736406
118PDK10.48392141
119IKBKB0.46172272
120MAPKAPK20.46141825
121SIK20.45661576
122PIK3CA0.45386545
123CAMK1G0.44725188
124HCK0.44607887
125WNK10.44594724
126CSNK1A10.44066102
127WNK40.44023148
128MAPK70.43758508
129MAP4K10.43640867
130MAP3K10.43407528
131MOS0.41700974
132ATM0.41644849
133MAP3K70.41216612
134NME10.39220364
135MARK30.39158832
136PINK10.38435985
137PRKG10.38315000
138PRKD20.37785993
139PAK30.37296532
140PRPF4B0.36417430
141EPHB10.35893109
142ITK0.35189178
143RPS6KA40.34751767
144BTK0.33818043
145SGK10.33478751
146GRK60.33366783
147CDK40.31914273
148BRAF0.31815382
149MAP3K40.31642688
150ADRBK10.31218195
151DYRK1A0.30777319
152RAF10.30434180
153PLK30.30433534
154TTK0.30290854
155STK110.30169223
156TAF10.28807527

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001902.63847216
2Nicotine addiction_Homo sapiens_hsa050332.57058347
3Protein export_Homo sapiens_hsa030602.21079010
4Staphylococcus aureus infection_Homo sapiens_hsa051502.15100857
5Ribosome_Homo sapiens_hsa030101.89890341
6Parkinsons disease_Homo sapiens_hsa050121.86704415
7Alzheimers disease_Homo sapiens_hsa050101.86086829
8Ether lipid metabolism_Homo sapiens_hsa005651.77158557
9Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.75986966
10Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.73399632
11Fanconi anemia pathway_Homo sapiens_hsa034601.70346733
12Serotonergic synapse_Homo sapiens_hsa047261.68414330
13Huntingtons disease_Homo sapiens_hsa050161.62269745
14Jak-STAT signaling pathway_Homo sapiens_hsa046301.61245768
15Toll-like receptor signaling pathway_Homo sapiens_hsa046201.58483118
16Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.56242902
17Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.50710038
18Homologous recombination_Homo sapiens_hsa034401.48511593
19Non-homologous end-joining_Homo sapiens_hsa034501.47287151
20RNA polymerase_Homo sapiens_hsa030201.45463113
21Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.45246456
22Legionellosis_Homo sapiens_hsa051341.41563675
23Glutamatergic synapse_Homo sapiens_hsa047241.41266404
24RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.38232754
25Collecting duct acid secretion_Homo sapiens_hsa049661.37694358
26Sphingolipid metabolism_Homo sapiens_hsa006001.37235798
27Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.33681805
28Phototransduction_Homo sapiens_hsa047441.32922793
29Toxoplasmosis_Homo sapiens_hsa051451.31106636
30Antigen processing and presentation_Homo sapiens_hsa046121.31027522
31Basal transcription factors_Homo sapiens_hsa030221.30878981
32Rheumatoid arthritis_Homo sapiens_hsa053231.30649773
33Non-small cell lung cancer_Homo sapiens_hsa052231.29849577
34Primary immunodeficiency_Homo sapiens_hsa053401.29561849
35SNARE interactions in vesicular transport_Homo sapiens_hsa041301.28516780
36Morphine addiction_Homo sapiens_hsa050321.27394052
37Platelet activation_Homo sapiens_hsa046111.23940534
38Acute myeloid leukemia_Homo sapiens_hsa052211.23813905
39Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.22465895
40Long-term depression_Homo sapiens_hsa047301.21868209
41Steroid biosynthesis_Homo sapiens_hsa001001.20746927
42TNF signaling pathway_Homo sapiens_hsa046681.20736605
43Axon guidance_Homo sapiens_hsa043601.20461346
44Allograft rejection_Homo sapiens_hsa053301.19733190
45Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.19431220
46Taste transduction_Homo sapiens_hsa047421.18761126
47Autoimmune thyroid disease_Homo sapiens_hsa053201.18724675
48Influenza A_Homo sapiens_hsa051641.18117016
49NF-kappa B signaling pathway_Homo sapiens_hsa040641.16716910
50Fatty acid elongation_Homo sapiens_hsa000621.16504214
51Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.14320806
52Viral myocarditis_Homo sapiens_hsa054161.12804287
53Hepatitis B_Homo sapiens_hsa051611.10958105
54Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.10795277
55Prolactin signaling pathway_Homo sapiens_hsa049171.07991837
56Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.06467660
57Hematopoietic cell lineage_Homo sapiens_hsa046401.06010533
58Graft-versus-host disease_Homo sapiens_hsa053321.03758177
59Mismatch repair_Homo sapiens_hsa034301.02948277
60Herpes simplex infection_Homo sapiens_hsa051680.99648550
61Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.99263240
62Asthma_Homo sapiens_hsa053100.98674528
63Intestinal immune network for IgA production_Homo sapiens_hsa046720.98670035
64FoxO signaling pathway_Homo sapiens_hsa040680.97581560
65Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.93979037
66Amphetamine addiction_Homo sapiens_hsa050310.93168927
67Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.92939996
68mTOR signaling pathway_Homo sapiens_hsa041500.92706410
69African trypanosomiasis_Homo sapiens_hsa051430.90256405
70Cocaine addiction_Homo sapiens_hsa050300.89148170
71Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.88369001
72GABAergic synapse_Homo sapiens_hsa047270.88088294
73Leukocyte transendothelial migration_Homo sapiens_hsa046700.87838721
74Renin secretion_Homo sapiens_hsa049240.87251420
75Endometrial cancer_Homo sapiens_hsa052130.85336747
76Long-term potentiation_Homo sapiens_hsa047200.84738153
77Pancreatic cancer_Homo sapiens_hsa052120.83964601
78Hepatitis C_Homo sapiens_hsa051600.83898076
79NOD-like receptor signaling pathway_Homo sapiens_hsa046210.82689193
80Circadian entrainment_Homo sapiens_hsa047130.81931348
81Linoleic acid metabolism_Homo sapiens_hsa005910.81097470
82Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.81003760
83Arachidonic acid metabolism_Homo sapiens_hsa005900.80364729
84Nucleotide excision repair_Homo sapiens_hsa034200.80249104
85Lysosome_Homo sapiens_hsa041420.79880080
86Inositol phosphate metabolism_Homo sapiens_hsa005620.77604704
87Colorectal cancer_Homo sapiens_hsa052100.76745865
88Measles_Homo sapiens_hsa051620.76672636
89Cardiac muscle contraction_Homo sapiens_hsa042600.76318621
90Carbohydrate digestion and absorption_Homo sapiens_hsa049730.76205131
91Systemic lupus erythematosus_Homo sapiens_hsa053220.75152681
92Apoptosis_Homo sapiens_hsa042100.74921464
93T cell receptor signaling pathway_Homo sapiens_hsa046600.74617733
94Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.72613379
95RNA degradation_Homo sapiens_hsa030180.71436197
96Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.71281144
97Renal cell carcinoma_Homo sapiens_hsa052110.71104284
98Spliceosome_Homo sapiens_hsa030400.71061370
99DNA replication_Homo sapiens_hsa030300.70685127
100Maturity onset diabetes of the young_Homo sapiens_hsa049500.68955195
101Phagosome_Homo sapiens_hsa041450.68893139
102Other glycan degradation_Homo sapiens_hsa005110.68847847
103Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.68538017
104Prostate cancer_Homo sapiens_hsa052150.67881529
105Viral carcinogenesis_Homo sapiens_hsa052030.67346065
106Cholinergic synapse_Homo sapiens_hsa047250.67057333
107Neurotrophin signaling pathway_Homo sapiens_hsa047220.66966976
108Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.66125531
109Vibrio cholerae infection_Homo sapiens_hsa051100.65986727
110B cell receptor signaling pathway_Homo sapiens_hsa046620.65772112
111Alcoholism_Homo sapiens_hsa050340.64728158
112Salivary secretion_Homo sapiens_hsa049700.64599670
113Dopaminergic synapse_Homo sapiens_hsa047280.64298141
114Malaria_Homo sapiens_hsa051440.64033504
115Chronic myeloid leukemia_Homo sapiens_hsa052200.63348788
116Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.61509496
117Pyrimidine metabolism_Homo sapiens_hsa002400.59352509
118Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.59343503
119Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.58806929
120alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.58097631
121Type II diabetes mellitus_Homo sapiens_hsa049300.56801252
122Osteoclast differentiation_Homo sapiens_hsa043800.56376617
123Circadian rhythm_Homo sapiens_hsa047100.56267196
124Calcium signaling pathway_Homo sapiens_hsa040200.54318084
125Purine metabolism_Homo sapiens_hsa002300.53289396
126Glycerophospholipid metabolism_Homo sapiens_hsa005640.52124158
127Phospholipase D signaling pathway_Homo sapiens_hsa040720.51758465
128Regulation of autophagy_Homo sapiens_hsa041400.51113539
129Glycosaminoglycan degradation_Homo sapiens_hsa005310.49442218
130Choline metabolism in cancer_Homo sapiens_hsa052310.49003715
131Epstein-Barr virus infection_Homo sapiens_hsa051690.48605793
132HIF-1 signaling pathway_Homo sapiens_hsa040660.48563566
133Phosphatidylinositol signaling system_Homo sapiens_hsa040700.47768533
134VEGF signaling pathway_Homo sapiens_hsa043700.46060815
135Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.45718931
136Transcriptional misregulation in cancer_Homo sapiens_hsa052020.45584004
137Chemokine signaling pathway_Homo sapiens_hsa040620.45179293
138Proteasome_Homo sapiens_hsa030500.43983170
139Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.43647223
140Insulin resistance_Homo sapiens_hsa049310.43441871
141MAPK signaling pathway_Homo sapiens_hsa040100.43148147
142Ras signaling pathway_Homo sapiens_hsa040140.42412611
143Endocytosis_Homo sapiens_hsa041440.42189070
144ABC transporters_Homo sapiens_hsa020100.41201426
145Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.41078472
146Dorso-ventral axis formation_Homo sapiens_hsa043200.40457826
147AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.40236010
148Leishmaniasis_Homo sapiens_hsa051400.39976151
149ErbB signaling pathway_Homo sapiens_hsa040120.39051246
150Type I diabetes mellitus_Homo sapiens_hsa049400.36988073
151Vascular smooth muscle contraction_Homo sapiens_hsa042700.36625663
152Notch signaling pathway_Homo sapiens_hsa043300.36125339
153Gastric acid secretion_Homo sapiens_hsa049710.35904947
154Sphingolipid signaling pathway_Homo sapiens_hsa040710.35248400
155Tuberculosis_Homo sapiens_hsa051520.35035029

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »