AKAP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein binds to type I and type II regulatory subunits of PKA and anchors them to the mitochondrion. This protein is speculated to be involved in the cAMP-dependent signal transduction pathway and in directing RNA to a specific cellular compartment. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sperm motility (GO:0030317)5.45475461
2NADH metabolic process (GO:0006734)5.30161677
3sperm capacitation (GO:0048240)5.25405994
4DNA packaging (GO:0006323)5.24679723
5cell wall macromolecule catabolic process (GO:0016998)4.89798730
6cell wall macromolecule metabolic process (GO:0044036)4.89798730
7fusion of sperm to egg plasma membrane (GO:0007342)4.84150109
8L-phenylalanine catabolic process (GO:0006559)4.77682033
9erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.77682033
10L-phenylalanine metabolic process (GO:0006558)4.75069962
11erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.75069962
12lysine catabolic process (GO:0006554)4.72998113
13lysine metabolic process (GO:0006553)4.72998113
14alpha-linolenic acid metabolic process (GO:0036109)4.68585871
15carnitine shuttle (GO:0006853)4.68107878
16sperm-egg recognition (GO:0035036)4.59720679
17fatty acid transmembrane transport (GO:1902001)4.59637989
18carnitine transport (GO:0015879)4.53004195
19amino-acid betaine transport (GO:0015838)4.53004195
20carnitine transmembrane transport (GO:1902603)4.52484312
21serine family amino acid catabolic process (GO:0009071)4.51119469
22fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.50873286
23amino-acid betaine metabolic process (GO:0006577)4.42102063
24binding of sperm to zona pellucida (GO:0007339)4.40125439
25glyoxylate metabolic process (GO:0046487)4.37422361
26acrosome reaction (GO:0007340)4.34107201
27sulfur amino acid catabolic process (GO:0000098)4.26029017
28urea cycle (GO:0000050)4.25795067
29urea metabolic process (GO:0019627)4.25795067
30triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.19986778
31aromatic amino acid family catabolic process (GO:0009074)4.16956542
32glycine metabolic process (GO:0006544)4.15321540
33kynurenine metabolic process (GO:0070189)4.14946720
34aspartate family amino acid catabolic process (GO:0009068)4.14862022
35sexual reproduction (GO:0019953)4.09075763
36cell-cell recognition (GO:0009988)4.07000865
37cysteine metabolic process (GO:0006534)4.02662119
38organic cation transport (GO:0015695)3.92878241
39regulation of triglyceride catabolic process (GO:0010896)3.90974180
40carnitine metabolic process (GO:0009437)3.90636389
41actin-myosin filament sliding (GO:0033275)3.89914100
42muscle filament sliding (GO:0030049)3.89914100
43acetyl-CoA metabolic process (GO:0006084)3.88830715
44fatty acid beta-oxidation (GO:0006635)3.88347606
45nitrogen cycle metabolic process (GO:0071941)3.87702966
46spermatid development (GO:0007286)3.87427458
47negative regulation of fatty acid biosynthetic process (GO:0045717)3.86109173
48nuclear pore complex assembly (GO:0051292)3.76002274
49bile acid biosynthetic process (GO:0006699)3.75730597
50acrosome assembly (GO:0001675)3.75624063
51tricarboxylic acid cycle (GO:0006099)3.74949612
522-oxoglutarate metabolic process (GO:0006103)3.74188296
53homocysteine metabolic process (GO:0050667)3.71241111
54tryptophan catabolic process (GO:0006569)3.69222376
55indole-containing compound catabolic process (GO:0042436)3.69222376
56indolalkylamine catabolic process (GO:0046218)3.69222376
57negative regulation of fibrinolysis (GO:0051918)3.65135062
58skeletal muscle contraction (GO:0003009)3.63361098
59plasma membrane fusion (GO:0045026)3.62916788
60multicellular organism reproduction (GO:0032504)3.62427664
61serine family amino acid metabolic process (GO:0009069)3.61352766
62complement activation, alternative pathway (GO:0006957)3.60261641
63regulation of protein activation cascade (GO:2000257)3.59792153
64alpha-amino acid catabolic process (GO:1901606)3.57300761
65quaternary ammonium group transport (GO:0015697)3.57025214
66fatty acid catabolic process (GO:0009062)3.56214506
67fatty acid oxidation (GO:0019395)3.53320526
68sarcoplasmic reticulum calcium ion transport (GO:0070296)3.52776384
69regulation of sequestering of triglyceride (GO:0010889)3.50618699
70biotin metabolic process (GO:0006768)3.49703182
71response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.46704134
72lipid oxidation (GO:0034440)3.44586517
73triglyceride homeostasis (GO:0070328)3.42599758
74acylglycerol homeostasis (GO:0055090)3.42599758
75tryptophan metabolic process (GO:0006568)3.41768188
76chaperone-mediated protein complex assembly (GO:0051131)3.41749781
77regulation of complement activation (GO:0030449)3.38496694
78positive regulation of fatty acid beta-oxidation (GO:0032000)3.37541948
79cellular amino acid catabolic process (GO:0009063)3.37383626
80ethanol oxidation (GO:0006069)3.36830293
81bundle of His cell to Purkinje myocyte communication (GO:0086069)3.35700414
82bile acid metabolic process (GO:0008206)3.34179496
83synaptonemal complex assembly (GO:0007130)3.33317479
84plasma lipoprotein particle clearance (GO:0034381)3.32385034
85regulation of fatty acid oxidation (GO:0046320)3.31468224
86regulation of fatty acid beta-oxidation (GO:0031998)3.30002452
87reproduction (GO:0000003)3.29376789
88motile cilium assembly (GO:0044458)3.29307517
89oxaloacetate metabolic process (GO:0006107)3.28925352
90monocarboxylic acid catabolic process (GO:0072329)3.28338502
91regulation of fibrinolysis (GO:0051917)3.28316079
92cellular ketone body metabolic process (GO:0046950)3.28055921
93serine family amino acid biosynthetic process (GO:0009070)3.26512280
94creatine metabolic process (GO:0006600)3.25712607
95high-density lipoprotein particle remodeling (GO:0034375)3.25583348
96short-chain fatty acid metabolic process (GO:0046459)3.24467777
97synaptonemal complex organization (GO:0070193)3.23778656
98protein carboxylation (GO:0018214)3.23355702
99peptidyl-glutamic acid carboxylation (GO:0017187)3.23355702
100regulation of cilium movement (GO:0003352)3.22616143
101gluconeogenesis (GO:0006094)3.22482063
102actin-mediated cell contraction (GO:0070252)3.22475531
103coenzyme catabolic process (GO:0009109)3.21797843
104regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.16757094
105organic acid catabolic process (GO:0016054)3.15891505
106carboxylic acid catabolic process (GO:0046395)3.15891505
107negative regulation of fatty acid metabolic process (GO:0045922)3.12270660
108negative regulation of inclusion body assembly (GO:0090084)3.11755416
109fructose metabolic process (GO:0006000)3.10586072
110hexose biosynthetic process (GO:0019319)3.09957306
111aromatic amino acid family metabolic process (GO:0009072)3.09949167
112rRNA methylation (GO:0031167)3.09610661
113positive regulation of lipid catabolic process (GO:0050996)3.09592381
114dicarboxylic acid biosynthetic process (GO:0043650)3.09530734
115epithelial cilium movement (GO:0003351)3.09155101
116phosphatidylethanolamine biosynthetic process (GO:0006646)3.06270909
117regulation of cholesterol homeostasis (GO:2000188)3.05986378
118cellular modified amino acid catabolic process (GO:0042219)3.04393689
119sarcomere organization (GO:0045214)3.04137881
120fatty acid homeostasis (GO:0055089)3.02760016
121negative regulation of cholesterol transport (GO:0032375)3.01300325
122negative regulation of sterol transport (GO:0032372)3.01300325
123chromosome condensation (GO:0030261)3.00858915
124nuclear pore organization (GO:0006999)2.98121891
125very-low-density lipoprotein particle assembly (GO:0034379)2.96052217
126spermatid nucleus differentiation (GO:0007289)2.95165271
127glycogen catabolic process (GO:0005980)2.94073485
128proline biosynthetic process (GO:0006561)2.94001231
129regulation of bile acid biosynthetic process (GO:0070857)2.92116398
130striated muscle contraction (GO:0006941)2.89099574
131glycolytic process (GO:0006096)2.86309735
1324-hydroxyproline metabolic process (GO:0019471)2.83435538
133monosaccharide biosynthetic process (GO:0046364)2.82321350
134glucan catabolic process (GO:0009251)2.81926111
135mitotic chromosome condensation (GO:0007076)2.80531993
136response to muscle activity (GO:0014850)2.79125529
137myofibril assembly (GO:0030239)2.78716336
138microtubule severing (GO:0051013)2.76281200
139cytoskeletal anchoring at plasma membrane (GO:0007016)2.75941367
140desmosome organization (GO:0002934)2.75932599
141proline metabolic process (GO:0006560)2.72999788
142cardiac myofibril assembly (GO:0055003)2.72032535
143negative regulation of histone methylation (GO:0031061)2.70523325
144nucleus organization (GO:0006997)2.69696508
145nucleosome disassembly (GO:0006337)2.69516612
146protein-DNA complex disassembly (GO:0032986)2.69516612
147protein-lipid complex assembly (GO:0065005)2.69067889
148phosphatidylethanolamine metabolic process (GO:0046337)2.69021230
149plasma lipoprotein particle assembly (GO:0034377)2.68976327
150diacylglycerol metabolic process (GO:0046339)2.66912659
151low-density lipoprotein particle clearance (GO:0034383)2.65932997
152insulin-like growth factor receptor signaling pathway (GO:0048009)2.65213209
153chromatin silencing (GO:0006342)2.64743719
154intestinal absorption (GO:0050892)2.62474695
155receptor recycling (GO:0001881)2.62442575
156skeletal muscle adaptation (GO:0043501)2.62006855
157single strand break repair (GO:0000012)2.61341041
158cardiac muscle hypertrophy (GO:0003300)2.61017337
159histone H3-K9 demethylation (GO:0033169)2.60047082
160negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.59595764
161epithelial cell-cell adhesion (GO:0090136)2.55485712
162tricarboxylic acid metabolic process (GO:0072350)2.55062941
163peptidyl-lysine dimethylation (GO:0018027)2.55031636
164actin filament-based movement (GO:0030048)2.54816433
165cellular polysaccharide catabolic process (GO:0044247)2.54594942
166L-alpha-amino acid transmembrane transport (GO:1902475)2.54195280
167rRNA modification (GO:0000154)2.53136796
168microtubule depolymerization (GO:0007019)2.51999522
169cardiac muscle contraction (GO:0060048)2.51509427
170striated muscle hypertrophy (GO:0014897)2.48218965
171DNA conformation change (GO:0071103)2.47020117
172actomyosin structure organization (GO:0031032)2.46280018
173cell-substrate adherens junction assembly (GO:0007045)2.45874159

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* ESR1_17901129_ChIP-ChIP_LIVER_Mouse7.54651018
2* RXR_22158963_ChIP-Seq_LIVER_Mouse5.33380299
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.21530812
4* PPARA_22158963_ChIP-Seq_LIVER_Mouse4.96436438
5MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse4.70159212
6* LXR_22158963_ChIP-Seq_LIVER_Mouse4.31600155
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.56509036
8EGR1_23403033_ChIP-Seq_LIVER_Mouse3.56020330
9E2F7_22180533_ChIP-Seq_HELA_Human2.96448629
10TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.94210324
11TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.80876728
12CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.72812155
13NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.62361064
14ZNF263_19887448_ChIP-Seq_K562_Human2.53085569
15LXR_22292898_ChIP-Seq_THP-1_Human2.46847506
16MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.40616134
17PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.21059651
18CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.15238810
19STAT3_1855785_ChIP-Seq_MESCs_Mouse2.12211356
20RACK7_27058665_Chip-Seq_MCF-7_Human2.10129051
21THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.08288897
22SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.93325846
23NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.88029760
24TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.87616706
25* ESR2_21235772_ChIP-Seq_MCF-7_Human1.86917443
26ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.76128422
27EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.74810875
28FOXM1_23109430_ChIP-Seq_U2OS_Human1.74782316
29* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.74228263
30* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.71535018
31* RUNX1_27514584_Chip-Seq_MCF-7_Human1.66180755
32RARG_19884340_ChIP-ChIP_MEFs_Mouse1.66017062
33TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.61602559
34TP63_17297297_ChIP-ChIP_HaCaT_Human1.57919884
35GATA6_25053715_ChIP-Seq_YYC3_Human1.56076055
36POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.52388355
37* RXRA_24833708_ChIP-Seq_LIVER_Mouse1.47969266
38TCF7_22412390_ChIP-Seq_EML_Mouse1.47590035
39KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.44983975
40ZFP281_18757296_ChIP-ChIP_E14_Mouse1.43713370
41CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.40092554
42NFIB_24661679_ChIP-Seq_LUNG_Mouse1.35498031
43ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.34502444
44EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.34027869
45KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.33625810
46TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.32701424
47NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.32666759
48CREB1_26743006_Chip-Seq_LNCaP_Human1.31870905
49CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.29990303
50MYC_22102868_ChIP-Seq_BL_Human1.28788187
51* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.28778392
52DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.26698172
53KDM2B_26808549_Chip-Seq_K562_Human1.25385788
54ERG_21242973_ChIP-ChIP_JURKAT_Human1.23371574
55* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.23353991
56* RARA_24833708_ChIP-Seq_LIVER_Mouse1.23281117
57* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.22703034
58* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.20612407
59* FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.18666522
60SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.18178549
61HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.17613630
62KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.15662770
63HIF1A_21447827_ChIP-Seq_MCF-7_Human1.13047802
64AR_21909140_ChIP-Seq_LNCAP_Human1.12804658
65TET1_21451524_ChIP-Seq_MESCs_Mouse1.11652739
66TBX20_22080862_ChIP-Seq_HEART_Mouse1.11499963
67TBX20_22328084_ChIP-Seq_HEART_Mouse1.11499963
68* FOXA2_19822575_ChIP-Seq_HepG2_Human1.11173001
69* HNF4A_19822575_ChIP-Seq_HepG2_Human1.10792169
70CTCF_27219007_Chip-Seq_ERYTHROID_Human1.10511186
71P300_27058665_Chip-Seq_ZR-75-30cells_Human1.10238119
72* SA1_27219007_Chip-Seq_ERYTHROID_Human1.10191922
73* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.09958485
74PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.08319172
75STAT6_21828071_ChIP-Seq_BEAS2B_Human1.07872056
76TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.06554060
77RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.06457656
78* CLOCK_20551151_ChIP-Seq_293T_Human1.06139491
79SOX9_24532713_ChIP-Seq_HFSC_Mouse1.05712419
80BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.04648353
81E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.03350463
82CTCF_21964334_Chip-Seq_Bcells_Human1.03224188
83POU5F1_16518401_ChIP-PET_MESCs_Mouse1.02993380
84KAP1_22055183_ChIP-Seq_ESCs_Mouse1.02820893
85ETS1_21867929_ChIP-Seq_TH2_Mouse1.02786771
86BCOR_27268052_Chip-Seq_Bcells_Human1.02687732
87HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.02221995
88KDM2B_26808549_Chip-Seq_SUP-B15_Human1.02039121
89SA1_27219007_Chip-Seq_Bcells_Human1.01652659
90MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.01392942
91ESR1_20079471_ChIP-ChIP_T-47D_Human1.01350886
92* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.01261941
93TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.99898255
94JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.99622516
95ELK3_25401928_ChIP-Seq_HUVEC_Human0.99185990
96KDM2B_26808549_Chip-Seq_DND41_Human0.98727817
97* KLF4_18555785_ChIP-Seq_MESCs_Mouse0.98618051
98PHF8_20622854_ChIP-Seq_HELA_Human0.97706841
99RARB_24833708_ChIP-Seq_LIVER_Mouse0.96563100
100GATA1_26923725_Chip-Seq_HPCs_Mouse0.95454629
101GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.94383300
102* KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.93036561
103CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.91991294
104P68_20966046_ChIP-Seq_HELA_Human0.91837644
105SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.90581660
106NANOG_18555785_ChIP-Seq_MESCs_Mouse0.90007316
107* NANOG_21062744_ChIP-ChIP_HESCs_Human0.89980936
108FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.89666202
109YY1_22570637_ChIP-Seq_MALME-3M_Human0.89518064
110ESET_19884257_ChIP-Seq_ESCs_Mouse0.89054657
111POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.88881755
112SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.88378199
113SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.88231196
114* SOX2_22085726_ChIP-Seq_NPCs_Mouse0.88193679
115P53_21459846_ChIP-Seq_SAOS-2_Human0.87777490
116ESR1_15608294_ChIP-ChIP_MCF-7_Human0.87733291
117* LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.87600201
118SOX2_27498859_Chip-Seq_STOMACH_Mouse0.86916708
119* SOX2_18692474_ChIP-Seq_MESCs_Mouse0.86642203
120* POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.85803426
121ELK4_26923725_Chip-Seq_MESODERM_Mouse0.85703089
122SPI1_26923725_Chip-Seq_HPCs_Mouse0.85500964
123NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.83928932
124AUTS2_25519132_ChIP-Seq_293T-REX_Human0.82476532
125ELF1_20517297_ChIP-Seq_JURKAT_Human0.81656968
126* NANOG_18692474_ChIP-Seq_MEFs_Mouse0.81473479
127E2F1_20622854_ChIP-Seq_HELA_Human0.80980612
128RAC3_21632823_ChIP-Seq_H3396_Human0.79269804
129* RAD21_21589869_ChIP-Seq_MESCs_Mouse0.78891326
130* SOX2_18692474_ChIP-Seq_MEFs_Mouse0.78807741
131* TCF3_18692474_ChIP-Seq_MESCs_Mouse0.77730150
132MYCN_18555785_ChIP-Seq_MESCs_Mouse0.77585132
133ATF3_27146783_Chip-Seq_COLON_Human0.76385143
134TP63_22573176_ChIP-Seq_HFKS_Human0.75782608
135EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.75721147
136KAP1_27257070_Chip-Seq_ESCs_Mouse0.75698684
137MYC_18358816_ChIP-ChIP_MESCs_Mouse0.75364891
138ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.75339481
139GATA3_21867929_ChIP-Seq_CD8_Mouse0.75199481
140SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.75169025
141* NANOG_18692474_ChIP-Seq_MESCs_Mouse0.74771612
142STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.74033193
143BCL6_27268052_Chip-Seq_Bcells_Human0.73983655
144SMC4_20622854_ChIP-Seq_HELA_Human0.73916748
145STAT1_17558387_ChIP-Seq_HELA_Human0.73134258
146* MYC_27129775_Chip-Seq_CORNEA_Mouse0.72037932
147EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.71315830
148CTCF_27219007_Chip-Seq_Bcells_Human0.70970446
149DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.70957921
150SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.69891316
151* SOX2_18555785_ChIP-Seq_MESCs_Mouse0.69692777
152NANOG_16518401_ChIP-PET_MESCs_Mouse0.69523678

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.52345238
2MP0005410_abnormal_fertilization5.27056694
3MP0005360_urolithiasis5.08432074
4MP0005085_abnormal_gallbladder_physiolo4.58298525
5MP0005365_abnormal_bile_salt4.35319039
6MP0003806_abnormal_nucleotide_metabolis4.01874666
7MP0005670_abnormal_white_adipose3.23202672
8MP0008875_abnormal_xenobiotic_pharmacok3.12091587
9MP0003646_muscle_fatigue2.77773561
10MP0010329_abnormal_lipoprotein_level2.69425337
11MP0003252_abnormal_bile_duct2.64886814
12MP0002837_dystrophic_cardiac_calcinosis2.40850602
13MP0003705_abnormal_hypodermis_morpholog2.34811287
14MP0009840_abnormal_foam_cell2.32420944
15MP0010234_abnormal_vibrissa_follicle2.23888212
16MP0005332_abnormal_amino_acid2.17896897
17MP0005666_abnormal_adipose_tissue2.07349584
18MP0004145_abnormal_muscle_electrophysio2.02419824
19MP0004130_abnormal_muscle_cell1.94105539
20MP0003698_abnormal_male_reproductive1.91522556
21MP0004084_abnormal_cardiac_muscle1.87846885
22* MP0001929_abnormal_gametogenesis1.84950702
23MP0000678_abnormal_parathyroid_gland1.84817166
24MP0005083_abnormal_biliary_tract1.82942551
25MP0002118_abnormal_lipid_homeostasis1.73342158
26MP0000566_synostosis1.71815562
27MP0006036_abnormal_mitochondrial_physio1.69424540
28MP0002269_muscular_atrophy1.66518987
29MP0000609_abnormal_liver_physiology1.65998385
30MP0004264_abnormal_extraembryonic_tissu1.64687046
31MP0005319_abnormal_enzyme/_coenzyme1.62564919
32MP0005330_cardiomyopathy1.59364633
33MP0003693_abnormal_embryo_hatching1.53837513
34MP0004036_abnormal_muscle_relaxation1.51821114
35MP0000003_abnormal_adipose_tissue1.50715633
36MP0001666_abnormal_nutrient_absorption1.50465994
37MP0004019_abnormal_vitamin_homeostasis1.47044054
38MP0003195_calcinosis1.46164389
39MP0005409_darkened_coat_color1.43400887
40MP0005451_abnormal_body_composition1.42403764
41MP0005369_muscle_phenotype1.41210572
42MP0002249_abnormal_larynx_morphology1.39747496
43MP0000751_myopathy1.38299132
44MP0004185_abnormal_adipocyte_glucose1.37552666
45MP0004233_abnormal_muscle_weight1.34448129
46MP0003191_abnormal_cellular_cholesterol1.30898921
47MP0004087_abnormal_muscle_fiber1.30342452
48MP0009780_abnormal_chondrocyte_physiolo1.28640411
49MP0005076_abnormal_cell_differentiation1.26572383
50MP0002971_abnormal_brown_adipose1.26386791
51MP0003878_abnormal_ear_physiology1.26338935
52MP0005377_hearing/vestibular/ear_phenot1.26338935
53MP0006035_abnormal_mitochondrial_morpho1.21686368
54MP0004215_abnormal_myocardial_fiber1.20408564
55MP0001764_abnormal_homeostasis1.20061989
56* MP0002161_abnormal_fertility/fecundity1.19339518
57MP0003879_abnormal_hair_cell1.19222402
58MP0000733_abnormal_muscle_development1.16340959
59MP0010630_abnormal_cardiac_muscle1.15234039
60MP0005375_adipose_tissue_phenotype1.13936636
61MP0005266_abnormal_metabolism1.11288454
62MP0002210_abnormal_sex_determination1.11119688
63MP0003221_abnormal_cardiomyocyte_apopto1.08762958
64MP0003011_delayed_dark_adaptation1.07790080
65MP0005584_abnormal_enzyme/coenzyme_acti1.06523896
66MP0006138_congestive_heart_failure1.05233904
67MP0000749_muscle_degeneration1.01195270
68MP0001145_abnormal_male_reproductive0.99978404
69MP0005647_abnormal_sex_gland0.99588992
70MP0002653_abnormal_ependyma_morphology0.98651539
71MP0003123_paternal_imprinting0.98230379
72MP0008775_abnormal_heart_ventricle0.97264887
73MP0002108_abnormal_muscle_morphology0.95328953
74MP0003077_abnormal_cell_cycle0.94721630
75MP0003941_abnormal_skin_development0.94356545
76MP0001661_extended_life_span0.93171532
77MP0000598_abnormal_liver_morphology0.93034145
78MP0005385_cardiovascular_system_phenoty0.92916928
79MP0001544_abnormal_cardiovascular_syste0.92916928
80MP0004782_abnormal_surfactant_physiolog0.92352480
81MP0003868_abnormal_feces_composition0.90030029
82MP0001730_embryonic_growth_arrest0.89993036
83MP0004270_analgesia0.89411564
84MP0003718_maternal_effect0.88577550
85MP0000750_abnormal_muscle_regeneration0.88561934
86MP0000653_abnormal_sex_gland0.88346433
87MP0009643_abnormal_urine_homeostasis0.87978356
88MP0004858_abnormal_nervous_system0.86610393
89MP0005620_abnormal_muscle_contractility0.84232974
90MP0001849_ear_inflammation0.82804124
91MP0005380_embryogenesis_phenotype0.81986919
92MP0001672_abnormal_embryogenesis/_devel0.81986919
93MP0009115_abnormal_fat_cell0.81818696
94MP0003984_embryonic_growth_retardation0.79708554
95MP0002088_abnormal_embryonic_growth/wei0.79581243
96MP0000467_abnormal_esophagus_morphology0.79121194
97MP0003186_abnormal_redox_activity0.77947098
98MP0002089_abnormal_postnatal_growth/wei0.77836037
99MP0009672_abnormal_birth_weight0.76446814
100MP0000762_abnormal_tongue_morphology0.76366810
101MP0000747_muscle_weakness0.74686036
102MP0002106_abnormal_muscle_physiology0.74147809
103MP0002970_abnormal_white_adipose0.73631147
104MP0008877_abnormal_DNA_methylation0.73457982
105MP0003950_abnormal_plasma_membrane0.73417003
106MP0002078_abnormal_glucose_homeostasis0.72964258
107MP0002972_abnormal_cardiac_muscle0.72360512
108MP0002332_abnormal_exercise_endurance0.72183862
109MP0002080_prenatal_lethality0.71908842
110MP0003566_abnormal_cell_adhesion0.71775592
111MP0003137_abnormal_impulse_conducting0.71658564
112MP0003329_amyloid_beta_deposits0.71535270
113MP0001348_abnormal_lacrimal_gland0.71063489
114MP0005376_homeostasis/metabolism_phenot0.70346857
115MP0003111_abnormal_nucleus_morphology0.69917875
116MP0005334_abnormal_fat_pad0.68373807
117MP0000579_abnormal_nail_morphology0.67398888
118MP0001765_abnormal_ion_homeostasis0.67314923
119MP0000534_abnormal_ureter_morphology0.66678750
120MP0002822_catalepsy0.66176669
121MP0004484_altered_response_of0.64820805
122MP0000537_abnormal_urethra_morphology0.63938739
123MP0002127_abnormal_cardiovascular_syste0.63760247
124MP0000759_abnormal_skeletal_muscle0.63655570
125MP0009697_abnormal_copulation0.63312869
126MP0010368_abnormal_lymphatic_system0.63252833
127MP0002796_impaired_skin_barrier0.58943318
128MP0003567_abnormal_fetal_cardiomyocyte0.58880550
129MP0000358_abnormal_cell_content/0.57955045
130MP0002086_abnormal_extraembryonic_tissu0.57477693
131MP0002138_abnormal_hepatobiliary_system0.56904626
132MP0005395_other_phenotype0.56841632
133MP0010352_gastrointestinal_tract_polyps0.56765829
134MP0004197_abnormal_fetal_growth/weight/0.56156825
135MP0001697_abnormal_embryo_size0.54290662
136MP0004957_abnormal_blastocyst_morpholog0.53603463
137MP0009053_abnormal_anal_canal0.53552036

Predicted human phenotypes

RankGene SetZ-score
1Nemaline bodies (HP:0003798)5.37413633
2Muscle fiber inclusion bodies (HP:0100299)5.37404561
3Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)5.19722523
4Intrahepatic cholestasis (HP:0001406)4.90091682
5Hyperglycinuria (HP:0003108)4.89040255
6Deep venous thrombosis (HP:0002625)4.84801717
7Hyperglycinemia (HP:0002154)4.50805377
8Abnormality of serine family amino acid metabolism (HP:0010894)4.39666181
9Abnormality of glycine metabolism (HP:0010895)4.39666181
10Hyperammonemia (HP:0001987)4.34869460
11Abnormality of monocarboxylic acid metabolism (HP:0010996)4.33369254
12Xanthomatosis (HP:0000991)4.33102453
13Hypobetalipoproteinemia (HP:0003563)4.24484047
14Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.22971829
15Abnormality of aromatic amino acid family metabolism (HP:0004338)4.14846996
16Absent/shortened dynein arms (HP:0200106)4.09135751
17Dynein arm defect of respiratory motile cilia (HP:0012255)4.09135751
18Ketosis (HP:0001946)4.05773308
19Type 1 muscle fiber predominance (HP:0003803)4.01342545
20Myoglobinuria (HP:0002913)3.93478544
21Hypoalphalipoproteinemia (HP:0003233)3.87165129
22Hypolipoproteinemia (HP:0010981)3.82575053
23Centrally nucleated skeletal muscle fibers (HP:0003687)3.70584426
24Hypoglycemic coma (HP:0001325)3.68270935
25Hyperlipoproteinemia (HP:0010980)3.66305951
26Hyperkalemia (HP:0002153)3.66210727
27Rhabdomyolysis (HP:0003201)3.57461867
28Abnormality of fatty-acid metabolism (HP:0004359)3.51080319
29Myopathic facies (HP:0002058)3.49701646
30Epidermoid cyst (HP:0200040)3.42996400
31Complement deficiency (HP:0004431)3.39862287
32Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.39534506
33Distal lower limb muscle weakness (HP:0009053)3.36754179
34Prolonged partial thromboplastin time (HP:0003645)3.19173133
35Muscle hypertrophy of the lower extremities (HP:0008968)3.16149658
36EMG: myopathic abnormalities (HP:0003458)3.10101756
37Ketoacidosis (HP:0001993)3.10096224
38Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.09267789
39Hypercholesterolemia (HP:0003124)3.08905513
40Abnormality of dicarboxylic acid metabolism (HP:0010995)3.04736110
41Dicarboxylic aciduria (HP:0003215)3.04736110
42Infertility (HP:0000789)3.02853195
43Exercise-induced myalgia (HP:0003738)3.00884712
44Abnormality of sulfur amino acid metabolism (HP:0004339)2.99728578
45Abnormality of serum amino acid levels (HP:0003112)2.96999485
46Abnormality of aspartate family amino acid metabolism (HP:0010899)2.92318212
47Abnormality of the left ventricular outflow tract (HP:0011103)2.90512731
48Subaortic stenosis (HP:0001682)2.90512731
49Exercise-induced muscle cramps (HP:0003710)2.88203290
50Abnormal gallbladder physiology (HP:0012438)2.85984045
51Cholecystitis (HP:0001082)2.85984045
52Male infertility (HP:0003251)2.82719164
53Calf muscle hypertrophy (HP:0008981)2.81618576
54Abnormality of glutamine family amino acid metabolism (HP:0010902)2.79553529
55Sudden death (HP:0001699)2.73516411
56Hyporeflexia of lower limbs (HP:0002600)2.70704186
57Abnormality of methionine metabolism (HP:0010901)2.70701763
58Neck muscle weakness (HP:0000467)2.69212612
59Gout (HP:0001997)2.64911738
60Abnormality of the lower motor neuron (HP:0002366)2.64516168
61Distal lower limb amyotrophy (HP:0008944)2.63451709
62Distal arthrogryposis (HP:0005684)2.59889673
63Muscle stiffness (HP:0003552)2.58978669
64Impulsivity (HP:0100710)2.57586523
65Abnormality of pyrimidine metabolism (HP:0004353)2.53368411
66Abnormality of complement system (HP:0005339)2.50865142
67Lethargy (HP:0001254)2.50564306
68Abnormal respiratory epithelium morphology (HP:0012253)2.50256504
69Abnormal respiratory motile cilium morphology (HP:0005938)2.50256504
70Chronic bronchitis (HP:0004469)2.50029541
71Abnormal respiratory motile cilium physiology (HP:0012261)2.49718957
72Progressive muscle weakness (HP:0003323)2.48795519
73Resting tremor (HP:0002322)2.48784819
74Abnormality of the calf musculature (HP:0001430)2.47196532
75Bundle branch block (HP:0011710)2.40698087
76Atrioventricular block (HP:0001678)2.39965116
77Ventricular tachycardia (HP:0004756)2.39198233
78Round ear (HP:0100830)2.38841576
79Increased connective tissue (HP:0009025)2.38354714
80Mildly elevated creatine phosphokinase (HP:0008180)2.36714751
81Muscle fiber splitting (HP:0003555)2.36036152
82Right ventricular cardiomyopathy (HP:0011663)2.34282344
83Ulnar deviation of the wrist (HP:0003049)2.33951997
84Abnormality of glycolysis (HP:0004366)2.32567623
85Malnutrition (HP:0004395)2.31296303
86Skin nodule (HP:0200036)2.29898916
87Abnormality of nucleobase metabolism (HP:0010932)2.28755495
88Abnormality of skeletal muscle fiber size (HP:0012084)2.27168798
89Metabolic acidosis (HP:0001942)2.26616460
90Hemorrhage of the eye (HP:0011885)2.26081081
91Cerebral edema (HP:0002181)2.24472082
92Dilated cardiomyopathy (HP:0001644)2.24062252
93Flat acetabular roof (HP:0003180)2.23521465
94Fat malabsorption (HP:0002630)2.22366633
95Asymmetric septal hypertrophy (HP:0001670)2.22026621
96Abnormality of the intrinsic pathway (HP:0010989)2.18099267
97Abnormality of purine metabolism (HP:0004352)2.16449038
98Hyperinsulinemic hypoglycemia (HP:0000825)2.16011467
99Dysmetric saccades (HP:0000641)2.15690776
100Abnormal cartilage morphology (HP:0002763)2.14467227
101Cholelithiasis (HP:0001081)2.14359782
102Delayed CNS myelination (HP:0002188)2.14323603
103Spastic diplegia (HP:0001264)2.13488391
104Difficulty running (HP:0009046)2.12753641
105Abnormality of the common coagulation pathway (HP:0010990)2.11768773
106Increased purine levels (HP:0004368)2.11389049
107Hyperuricemia (HP:0002149)2.11389049
108Increased serum pyruvate (HP:0003542)2.11165191
109Heart block (HP:0012722)2.10920969
110Multiple enchondromatosis (HP:0005701)2.08493406
111Nasal polyposis (HP:0100582)2.05319040
112Ragged-red muscle fibers (HP:0003200)2.04184940
113Hyperglycemia (HP:0003074)2.04071960
114Difficulty climbing stairs (HP:0003551)2.03905556
115Rimmed vacuoles (HP:0003805)2.03229438
116Hypochromic microcytic anemia (HP:0004840)2.02743375
117Global brain atrophy (HP:0002283)2.00168292
118Abnormal gallbladder morphology (HP:0012437)1.98565386
119Hepatocellular carcinoma (HP:0001402)1.96908443
120EMG: neuropathic changes (HP:0003445)1.96420142
121Hyperbilirubinemia (HP:0002904)1.95557682
122Rhinitis (HP:0012384)1.94673411
123Abnormal atrioventricular conduction (HP:0005150)1.94569052
124Malignant hyperthermia (HP:0002047)1.94298826
125Increased variability in muscle fiber diameter (HP:0003557)1.92585011
126Progressive sensorineural hearing impairment (HP:0000408)1.91914253
127Joint hemorrhage (HP:0005261)1.89835465
128Abnormal spermatogenesis (HP:0008669)1.89083778
129Insulin-resistant diabetes mellitus (HP:0000831)1.88973653
130Myocardial infarction (HP:0001658)1.88672508
131Vascular calcification (HP:0004934)1.88640080
132Bulbar palsy (HP:0001283)1.88605844
133Subcapsular cataract (HP:0000523)1.87835781
134Insulin resistance (HP:0000855)1.87040404
135Calcaneovalgus deformity (HP:0001848)1.86784085
136Lower limb amyotrophy (HP:0007210)1.86066057
137Abnormality of the salivary glands (HP:0010286)1.82403111
138Abnormality of the Achilles tendon (HP:0005109)1.82188067
139Palpitations (HP:0001962)1.81928573
140Hypertriglyceridemia (HP:0002155)1.81300961
141Achilles tendon contracture (HP:0001771)1.76415280
142Progressive hearing impairment (HP:0001730)1.73320962
143Lipoatrophy (HP:0100578)1.72949699
144Osteomalacia (HP:0002749)1.71677005
145Facial shape deformation (HP:0011334)1.71389481
146Potter facies (HP:0002009)1.71389481
147Hyponatremia (HP:0002902)1.69650747
148Abnormality of potassium homeostasis (HP:0011042)1.69335563
149Renovascular hypertension (HP:0100817)1.69274289
150Advanced eruption of teeth (HP:0006288)1.64449585
151Esophageal varix (HP:0002040)1.63957957
152Abnormality of carpal bone ossification (HP:0006257)1.61703410
153Generalized muscle weakness (HP:0003324)1.59557943
154Abnormal tarsal ossification (HP:0008369)1.58648370
155Back pain (HP:0003418)1.57140029
156Trismus (HP:0000211)1.56798926

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK36.07536470
2PDK46.07536470
3PDK23.82237018
4ICK3.74675122
5BCKDK3.50861502
6TESK12.95965766
7PRKD32.95631432
8TRIB32.52520657
9PKN22.49622643
10SMG12.29664765
11PLK42.25983814
12NEK12.19492612
13TTN1.86184781
14BRD41.71896190
15LATS11.71560691
16STK38L1.67789576
17STK381.67338477
18NEK21.64216215
19TTK1.63007361
20SIK11.61428849
21MAP3K91.54212576
22CDK121.46270278
23LATS21.41312652
24EEF2K1.39569354
25DMPK1.39053037
26PINK11.39025416
27EPHA21.36099641
28KSR21.23071685
29LMTK21.19148180
30OBSCN1.18793035
31NEK61.16492720
32WEE11.11896066
33NME11.11345427
34MTOR1.07019665
35MAP3K101.05422092
36ERN11.03639190
37FGFR41.01084435
38TYRO31.00705792
39DYRK1B0.97168351
40PRKAA10.97091015
41ERBB40.96694773
42PNCK0.94812644
43CDK40.93350410
44PHKG20.93235789
45PHKG10.93235789
46SCYL20.92791865
47RIPK10.92238080
48WNK40.91966364
49STK30.89917211
50PIK3CA0.88186544
51ARAF0.87847540
52WNK10.86286658
53PRPF4B0.85211938
54FLT30.84646336
55MAP3K130.83463681
56PTK2B0.82182188
57PBK0.78095283
58NME20.78024154
59CAMK1D0.77949017
60PDK10.75798072
61BRAF0.71678725
62PRKAA20.71372904
63IRAK30.69021098
64PDPK10.68957511
65MAPK110.68405611
66MET0.67253882
67PDGFRA0.65141694
68CAMK1G0.65059742
69FGFR30.64330038
70CDK60.63819108
71AKT30.63082341
72CHEK20.63080710
73MAPKAPK30.60483283
74MAP2K20.59903912
75MUSK0.58544682
76MST1R0.57295295
77PIK3CG0.57158326
78PRKG20.56449237
79DYRK30.56332357
80PLK10.55801885
81PAK20.55738965
82CDK10.52662244
83MAP2K40.52351813
84MAP3K10.49282804
85PTK60.48981956
86BRSK10.47602437
87PTK20.47597696
88CHEK10.46915381
89RPS6KA20.45703467
90STK390.45252651
91BUB10.44958994
92MAPK100.44954719
93CDC70.44882704
94MYLK0.44065821
95MAP3K80.44011089
96* GSK3B0.43576505
97MAP3K50.42869559
98CAMK2G0.42448158
99SRPK10.42360747
100TIE10.41715483
101TRPM70.41293235
102MAP3K60.40854486
103AKT20.40404641
104RPS6KB10.39794788
105MAP3K70.39149097
106FGFR10.38424559
107CAMK40.38407431
108CDK90.37951147
109MAP2K30.36935333
110PAK40.36166529
111RET0.36081289
112MAPK140.35799109
113CSNK1E0.35627702
114MAP2K60.34792078
115TAOK20.33885694
116MAP2K10.33463879
117BMX0.33345934
118PRKACG0.32835545
119MAP3K20.32813267
120MARK20.32001633
121ALK0.31292539
122AURKB0.31062619
123PAK30.30793292
124MAP3K30.30375164
125STK40.29990330
126CSNK1D0.29910880
127RPS6KB20.29400849
128GSK3A0.28703149
129RPS6KA10.28559051
130AURKA0.28521763
131ATM0.27686414
132ABL20.27361049
133BRSK20.27054764
134PAK10.26944200
135PRKCZ0.25430090
136* CDK20.23814676
137MAPK120.23603766
138CDK70.23194162
139PRKACB0.21852021
140PAK60.21464821
141DDR20.20145245
142TAOK10.19739179
143MELK0.19624977

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.19358852
2Fatty acid degradation_Homo sapiens_hsa000713.14114040
3Propanoate metabolism_Homo sapiens_hsa006403.12012447
4Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006303.06555722
5Primary bile acid biosynthesis_Homo sapiens_hsa001202.98975857
6Nitrogen metabolism_Homo sapiens_hsa009102.92259228
72-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.79765060
8Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.58997731
9Fatty acid metabolism_Homo sapiens_hsa012122.56174432
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.56156118
11Arginine biosynthesis_Homo sapiens_hsa002202.48575104
12Pyruvate metabolism_Homo sapiens_hsa006202.34589036
13PPAR signaling pathway_Homo sapiens_hsa033202.33065074
14Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.29419376
15Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.25220593
16Carbon metabolism_Homo sapiens_hsa012002.21729029
17Tryptophan metabolism_Homo sapiens_hsa003802.11705178
18Fatty acid biosynthesis_Homo sapiens_hsa000612.07665695
19Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.05891658
20Vitamin B6 metabolism_Homo sapiens_hsa007501.96016226
21Butanoate metabolism_Homo sapiens_hsa006501.94391825
22Biosynthesis of amino acids_Homo sapiens_hsa012301.89575955
23Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.86699488
24Selenocompound metabolism_Homo sapiens_hsa004501.77592764
25Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.65395971
26Complement and coagulation cascades_Homo sapiens_hsa046101.63363084
27Peroxisome_Homo sapiens_hsa041461.62969677
28Pentose and glucuronate interconversions_Homo sapiens_hsa000401.56695595
29Cysteine and methionine metabolism_Homo sapiens_hsa002701.55852101
30beta-Alanine metabolism_Homo sapiens_hsa004101.46442644
31Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.40443532
32Fat digestion and absorption_Homo sapiens_hsa049751.39988856
33Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.36585569
34Chemical carcinogenesis_Homo sapiens_hsa052041.31936837
35Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.30815050
36Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.29520711
37Bile secretion_Homo sapiens_hsa049761.29317630
38Drug metabolism - other enzymes_Homo sapiens_hsa009831.27186250
39Glycerolipid metabolism_Homo sapiens_hsa005611.18453019
40Phenylalanine metabolism_Homo sapiens_hsa003601.12621947
41Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.10652161
42Caffeine metabolism_Homo sapiens_hsa002321.08947146
43Pentose phosphate pathway_Homo sapiens_hsa000301.07520128
44Fatty acid elongation_Homo sapiens_hsa000621.07431935
45Starch and sucrose metabolism_Homo sapiens_hsa005001.04601147
46Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.03739047
47Retinol metabolism_Homo sapiens_hsa008301.01281025
48Lysine degradation_Homo sapiens_hsa003101.00344753
49Fructose and mannose metabolism_Homo sapiens_hsa000510.99451875
50Tyrosine metabolism_Homo sapiens_hsa003500.99429250
51Renin-angiotensin system_Homo sapiens_hsa046140.99224445
52Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.99023043
53Steroid hormone biosynthesis_Homo sapiens_hsa001400.97676461
54Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.97631101
55Thyroid cancer_Homo sapiens_hsa052160.96873203
56Histidine metabolism_Homo sapiens_hsa003400.94910468
57Arginine and proline metabolism_Homo sapiens_hsa003300.93831952
58One carbon pool by folate_Homo sapiens_hsa006700.93175885
59Glucagon signaling pathway_Homo sapiens_hsa049220.88742599
60Cyanoamino acid metabolism_Homo sapiens_hsa004600.88211952
61Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.87677177
62Tight junction_Homo sapiens_hsa045300.86737547
63Thyroid hormone signaling pathway_Homo sapiens_hsa049190.85149730
64Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.82695363
65Sulfur relay system_Homo sapiens_hsa041220.81657016
66Folate biosynthesis_Homo sapiens_hsa007900.80497322
67alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.78385411
68ABC transporters_Homo sapiens_hsa020100.78108881
69Glutathione metabolism_Homo sapiens_hsa004800.77261448
70Adherens junction_Homo sapiens_hsa045200.74245328
71Adipocytokine signaling pathway_Homo sapiens_hsa049200.66434528
72Linoleic acid metabolism_Homo sapiens_hsa005910.65811731
73Glycerophospholipid metabolism_Homo sapiens_hsa005640.63649609
74AMPK signaling pathway_Homo sapiens_hsa041520.62299023
75Sulfur metabolism_Homo sapiens_hsa009200.59914927
76Staphylococcus aureus infection_Homo sapiens_hsa051500.59823532
77Vitamin digestion and absorption_Homo sapiens_hsa049770.57426835
78Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.52355213
79Metabolic pathways_Homo sapiens_hsa011000.51932345
80Circadian rhythm_Homo sapiens_hsa047100.51896235
81Insulin resistance_Homo sapiens_hsa049310.51721551
82Thyroid hormone synthesis_Homo sapiens_hsa049180.48297305
83Cardiac muscle contraction_Homo sapiens_hsa042600.47976470
84Galactose metabolism_Homo sapiens_hsa000520.47703593
85Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.44828221
86Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.42861093
87Endometrial cancer_Homo sapiens_hsa052130.42279717
88Central carbon metabolism in cancer_Homo sapiens_hsa052300.41394529
89cGMP-PKG signaling pathway_Homo sapiens_hsa040220.38372728
90DNA replication_Homo sapiens_hsa030300.38314227
91Protein digestion and absorption_Homo sapiens_hsa049740.36899558
92Long-term potentiation_Homo sapiens_hsa047200.35103721
93Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.34816908
94RNA transport_Homo sapiens_hsa030130.33435580
95Inositol phosphate metabolism_Homo sapiens_hsa005620.31803292
96Aldosterone synthesis and secretion_Homo sapiens_hsa049250.31691635
97Mineral absorption_Homo sapiens_hsa049780.31593790
98Insulin signaling pathway_Homo sapiens_hsa049100.31377965
99Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.28169232
100Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.27375108
101Estrogen signaling pathway_Homo sapiens_hsa049150.27128818
102Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.26605672
103Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.26191186
104Acute myeloid leukemia_Homo sapiens_hsa052210.26041745
105Steroid biosynthesis_Homo sapiens_hsa001000.24750198
106Non-small cell lung cancer_Homo sapiens_hsa052230.24134856
107Longevity regulating pathway - mammal_Homo sapiens_hsa042110.18672301
108Maturity onset diabetes of the young_Homo sapiens_hsa049500.17985022
109Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.14287441
110Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.13794717
111Carbohydrate digestion and absorption_Homo sapiens_hsa049730.10169347
112Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.09974931
113mTOR signaling pathway_Homo sapiens_hsa041500.08775872
114Huntingtons disease_Homo sapiens_hsa050160.07567792
115Systemic lupus erythematosus_Homo sapiens_hsa053220.05062689
116mRNA surveillance pathway_Homo sapiens_hsa030150.04838337
117Dilated cardiomyopathy_Homo sapiens_hsa054140.04404785
118Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.04375142
119Prion diseases_Homo sapiens_hsa050200.04179330
120Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.01709310
121Oocyte meiosis_Homo sapiens_hsa041140.01540927
122Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.01331892
123Purine metabolism_Homo sapiens_hsa00230-0.0083440
124Pyrimidine metabolism_Homo sapiens_hsa00240-0.0042651

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