AK9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene catalyzes the interconversion of nucleosides, possessing both nucleoside monophosphate and diphosphate kinase activities. The encoded protein uses these interconversions to maintain nucleoside homeostasis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1motile cilium assembly (GO:0044458)9.02879333
2axoneme assembly (GO:0035082)8.39339955
3fusion of sperm to egg plasma membrane (GO:0007342)7.47773516
4piRNA metabolic process (GO:0034587)7.24458410
5multicellular organism reproduction (GO:0032504)6.98380456
6sperm motility (GO:0030317)6.98331405
7ventricular system development (GO:0021591)6.96148687
8GTP biosynthetic process (GO:0006183)6.79296296
9sperm-egg recognition (GO:0035036)6.50712255
10regulation of cilium movement (GO:0003352)6.30947020
11acrosome reaction (GO:0007340)6.29068820
12acrosome assembly (GO:0001675)6.18810509
13intraciliary transport (GO:0042073)6.06272341
14binding of sperm to zona pellucida (GO:0007339)5.97978238
15male meiosis (GO:0007140)5.92323569
16UTP biosynthetic process (GO:0006228)5.82225855
17cell-cell recognition (GO:0009988)5.72656172
18spermatid development (GO:0007286)5.64769694
19plasma membrane fusion (GO:0045026)5.54888111
20single fertilization (GO:0007338)5.42240585
21cilium organization (GO:0044782)5.30348009
22left/right axis specification (GO:0070986)5.28019246
23reproduction (GO:0000003)5.23558125
24DNA methylation involved in gamete generation (GO:0043046)5.15929919
25male meiosis I (GO:0007141)5.15043335
26regulation of memory T cell differentiation (GO:0043380)5.13422721
27* nucleoside diphosphate phosphorylation (GO:0006165)5.13109936
28UTP metabolic process (GO:0046051)5.08149234
29cilium assembly (GO:0042384)5.04558283
30synaptonemal complex organization (GO:0070193)5.01288195
31centriole assembly (GO:0098534)5.00765299
32cell wall macromolecule catabolic process (GO:0016998)4.97605052
33cell wall macromolecule metabolic process (GO:0044036)4.97605052
34centriole replication (GO:0007099)4.76276272
35protein localization to cilium (GO:0061512)4.71683929
36guanosine-containing compound biosynthetic process (GO:1901070)4.68339843
37meiotic cell cycle (GO:0051321)4.67793885
38synaptonemal complex assembly (GO:0007130)4.44154176
39CTP biosynthetic process (GO:0006241)4.43867879
40CTP metabolic process (GO:0046036)4.43867879
41fertilization (GO:0009566)4.41466424
42cilium morphogenesis (GO:0060271)4.34019205
43cellular component assembly involved in morphogenesis (GO:0010927)4.29502968
44sperm capacitation (GO:0048240)4.15621922
45behavioral response to nicotine (GO:0035095)4.14202894
46microtubule depolymerization (GO:0007019)4.13789724
47meiosis I (GO:0007127)4.11122142
48pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.99347472
49microtubule-based movement (GO:0007018)3.89902223
50pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)3.88378117
51spermatogenesis (GO:0007283)3.82458301
52L-fucose catabolic process (GO:0042355)3.82152581
53fucose catabolic process (GO:0019317)3.82152581
54L-fucose metabolic process (GO:0042354)3.82152581
55male gamete generation (GO:0048232)3.81369238
56chromosome organization involved in meiosis (GO:0070192)3.71059631
57microtubule bundle formation (GO:0001578)3.66038869
58rRNA catabolic process (GO:0016075)3.62285529
59negative regulation of inclusion body assembly (GO:0090084)3.61688670
60microtubule severing (GO:0051013)3.60525460
61meiotic nuclear division (GO:0007126)3.58142182
62gamete generation (GO:0007276)3.56072492
63pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)3.44936135
64pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.44780603
65indolalkylamine metabolic process (GO:0006586)3.42938356
66DNA deamination (GO:0045006)3.40151908
67left/right pattern formation (GO:0060972)3.36347705
68water-soluble vitamin biosynthetic process (GO:0042364)3.36130050
69negative regulation of mast cell activation (GO:0033004)3.35494069
70regulation of microtubule-based movement (GO:0060632)3.35339994
71spermatid nucleus differentiation (GO:0007289)3.31795528
72protein polyglutamylation (GO:0018095)3.29592140
73cellular ketone body metabolic process (GO:0046950)3.26476876
74cell projection assembly (GO:0030031)3.25721534
75positive regulation of defense response to virus by host (GO:0002230)3.23055715
76germ cell development (GO:0007281)3.22407395
77regulation of activation of Janus kinase activity (GO:0010533)3.18111538
78positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.16330751
79detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.14188198
80neural tube formation (GO:0001841)3.13890737
81cell recognition (GO:0008037)3.11515248
82photoreceptor cell maintenance (GO:0045494)3.10203633
83cellular process involved in reproduction in multicellular organism (GO:0022412)3.06535755
84tryptophan catabolic process (GO:0006569)3.05559436
85indole-containing compound catabolic process (GO:0042436)3.05559436
86indolalkylamine catabolic process (GO:0046218)3.05559436
87retinal cone cell development (GO:0046549)2.98512425
88regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.96252177
89response to pheromone (GO:0019236)2.96025726
90* nucleotide phosphorylation (GO:0046939)2.92740609
91positive regulation of cell fate commitment (GO:0010455)2.92283138
92regulation of inclusion body assembly (GO:0090083)2.90286666
93ketone body metabolic process (GO:1902224)2.90250693
94calcium ion-dependent exocytosis (GO:0017156)2.89426679
95negative regulation of cytosolic calcium ion concentration (GO:0051481)2.87925385
96determination of left/right symmetry (GO:0007368)2.87445496
97otic vesicle formation (GO:0030916)2.87200880
98synapsis (GO:0007129)2.86752341
99nonmotile primary cilium assembly (GO:0035058)2.82192915
100kynurenine metabolic process (GO:0070189)2.80181483
101detection of light stimulus involved in visual perception (GO:0050908)2.79627262
102detection of light stimulus involved in sensory perception (GO:0050962)2.79627262
103positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)2.78248349
104establishment of protein localization to Golgi (GO:0072600)2.78141882
105phosphatidylethanolamine metabolic process (GO:0046337)2.77931284
106regulation of meiosis I (GO:0060631)2.77836863
107multicellular organismal reproductive process (GO:0048609)2.75485947
108* nucleoside diphosphate metabolic process (GO:0009132)2.73058532
109tryptophan metabolic process (GO:0006568)2.71662389
110positive regulation of T-helper 1 type immune response (GO:0002827)2.71148538
111cellular biogenic amine catabolic process (GO:0042402)2.70663786
112amine catabolic process (GO:0009310)2.70663786
113organelle assembly (GO:0070925)2.69776537
114neuronal action potential (GO:0019228)2.69503011
115glycerophospholipid catabolic process (GO:0046475)2.67953063
116determination of bilateral symmetry (GO:0009855)2.67507012
117positive regulation of meiosis (GO:0045836)2.66888016
118phosphatidylethanolamine biosynthetic process (GO:0006646)2.66826714
119specification of symmetry (GO:0009799)2.62414868
120nucleotide transmembrane transport (GO:1901679)2.61595095
121adaptation of signaling pathway (GO:0023058)2.61100334
122microtubule polymerization or depolymerization (GO:0031109)2.59789240
123regulation of action potential (GO:0098900)2.58149290
124intra-S DNA damage checkpoint (GO:0031573)2.57621542
125gamma-aminobutyric acid transport (GO:0015812)2.57577925
126platelet dense granule organization (GO:0060155)2.56236900
127positive regulation of meiotic cell cycle (GO:0051446)2.55840188
128indole-containing compound metabolic process (GO:0042430)2.55236554
129behavioral response to ethanol (GO:0048149)2.53839031
130G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.53501015
131spinal cord motor neuron differentiation (GO:0021522)2.51200933
132regulation of pigment cell differentiation (GO:0050932)2.50031804
133smoothened signaling pathway (GO:0007224)2.49621025
134regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)2.49182407
135cellular response to gamma radiation (GO:0071480)2.48986409
136transmission of nerve impulse (GO:0019226)2.48725822
137pyrimidine ribonucleoside biosynthetic process (GO:0046132)2.46528201
138meiotic cell cycle process (GO:1903046)2.45198068
139reciprocal DNA recombination (GO:0035825)2.43771650
140reciprocal meiotic recombination (GO:0007131)2.43771650
141protein localization to Golgi apparatus (GO:0034067)2.42488434
142primary amino compound metabolic process (GO:1901160)2.41390915
143pyrimidine nucleobase catabolic process (GO:0006208)2.40790449
144auditory receptor cell stereocilium organization (GO:0060088)2.39874369
145kidney morphogenesis (GO:0060993)2.39472601
146central nervous system myelination (GO:0022010)2.39394277
147axon ensheathment in central nervous system (GO:0032291)2.39394277
148nucleobase catabolic process (GO:0046113)2.38308564
149protein targeting to Golgi (GO:0000042)2.38097726
150serotonin metabolic process (GO:0042428)2.36822751
151organic cation transport (GO:0015695)2.36723858
152respiratory chain complex IV assembly (GO:0008535)2.36188921
153cornea development in camera-type eye (GO:0061303)2.35246716
154pyrimidine nucleotide biosynthetic process (GO:0006221)2.34931582
155protein complex biogenesis (GO:0070271)2.34331081
156regulation of collateral sprouting (GO:0048670)2.33858500
157regulation of centriole replication (GO:0046599)2.33457749
158pyrimidine ribonucleotide biosynthetic process (GO:0009220)2.32749381
159protein import into peroxisome matrix (GO:0016558)2.32124415
160positive regulation of oligodendrocyte differentiation (GO:0048714)2.31501380
161reflex (GO:0060004)2.30649502
162regulation of rhodopsin mediated signaling pathway (GO:0022400)2.29687564
163microtubule-based process (GO:0007017)2.29506513
164brain morphogenesis (GO:0048854)2.29487172
165cilium or flagellum-dependent cell motility (GO:0001539)15.3700122
166axonemal dynein complex assembly (GO:0070286)13.3103261
167cilium movement (GO:0003341)12.7193786
168epithelial cilium movement (GO:0003351)11.3536441
169epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)10.2791820

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse4.89316700
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.87621715
3CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.57694494
4EZH2_22144423_ChIP-Seq_EOC_Human3.29763383
5ZNF274_21170338_ChIP-Seq_K562_Hela3.10886264
6FLI1_27457419_Chip-Seq_LIVER_Mouse2.80782883
7PCGF2_27294783_Chip-Seq_ESCs_Mouse2.78088869
8GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.63992183
9ZFP57_27257070_Chip-Seq_ESCs_Mouse2.36097694
10SUZ12_27294783_Chip-Seq_NPCs_Mouse2.26240967
11PCGF2_27294783_Chip-Seq_NPCs_Mouse2.20982535
12CBX2_27304074_Chip-Seq_ESCs_Mouse2.17886339
13NFE2_27457419_Chip-Seq_LIVER_Mouse2.15989960
14GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.15943198
15FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.12343766
16GBX2_23144817_ChIP-Seq_PC3_Human2.07334226
17RNF2_27304074_Chip-Seq_NSC_Mouse2.06273463
18TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.99358218
19BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.99289900
20EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.93194155
21POU3F2_20337985_ChIP-ChIP_501MEL_Human1.91565918
22NANOG_18555785_Chip-Seq_ESCs_Mouse1.88385012
23CTBP2_25329375_ChIP-Seq_LNCAP_Human1.84263983
24BMI1_23680149_ChIP-Seq_NPCS_Mouse1.82676153
25HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.80634902
26GATA1_26923725_Chip-Seq_HPCs_Mouse1.78719002
27STAT3_18555785_Chip-Seq_ESCs_Mouse1.77875703
28P53_22387025_ChIP-Seq_ESCs_Mouse1.75328351
29SUZ12_18555785_Chip-Seq_ESCs_Mouse1.74802096
30EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.74110387
31MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.73693836
32EZH2_27294783_Chip-Seq_NPCs_Mouse1.73556578
33ER_23166858_ChIP-Seq_MCF-7_Human1.73534108
34AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.69135270
35VDR_22108803_ChIP-Seq_LS180_Human1.67892846
36P300_18555785_Chip-Seq_ESCs_Mouse1.67473195
37E2F1_18555785_Chip-Seq_ESCs_Mouse1.67140063
38TAL1_26923725_Chip-Seq_HPCs_Mouse1.66480123
39KAP1_22055183_ChIP-Seq_ESCs_Mouse1.64447768
40OCT4_18555785_Chip-Seq_ESCs_Mouse1.64248284
41TAF15_26573619_Chip-Seq_HEK293_Human1.62719236
42EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.62694588
43POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.62159544
44TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.62159544
45CMYC_18555785_Chip-Seq_ESCs_Mouse1.60747011
46RUNX1_27457419_Chip-Seq_LIVER_Mouse1.58926112
47ZFX_18555785_Chip-Seq_ESCs_Mouse1.58063871
48KLF4_18555785_Chip-Seq_ESCs_Mouse1.57536198
49FUS_26573619_Chip-Seq_HEK293_Human1.56040273
50PIAS1_25552417_ChIP-Seq_VCAP_Human1.55710810
51SOX2_18555785_Chip-Seq_ESCs_Mouse1.55287462
52AR_25329375_ChIP-Seq_VCAP_Human1.51781692
53TP53_22573176_ChIP-Seq_HFKS_Human1.50755364
54P300_19829295_ChIP-Seq_ESCs_Human1.50675823
55CRX_20693478_ChIP-Seq_RETINA_Mouse1.49210073
56NMYC_18555785_Chip-Seq_ESCs_Mouse1.48764229
57RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.48413105
58BCAT_22108803_ChIP-Seq_LS180_Human1.46967053
59MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.46177961
60ESRRB_18555785_Chip-Seq_ESCs_Mouse1.45450776
61ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.44718020
62PU1_27457419_Chip-Seq_LIVER_Mouse1.43938692
63NR3C1_21868756_ChIP-Seq_MCF10A_Human1.43426484
64PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.42106965
65CTBP1_25329375_ChIP-Seq_LNCAP_Human1.41403624
66CTCF_18555785_Chip-Seq_ESCs_Mouse1.36863091
67SMAD4_21799915_ChIP-Seq_A2780_Human1.36281221
68NANOG_19829295_ChIP-Seq_ESCs_Human1.36253646
69SOX2_19829295_ChIP-Seq_ESCs_Human1.36253646
70RBPJ_22232070_ChIP-Seq_NCS_Mouse1.35139024
71SALL1_21062744_ChIP-ChIP_HESCs_Human1.34875478
72FOXA1_25329375_ChIP-Seq_VCAP_Human1.34361770
73FOXA1_27270436_Chip-Seq_PROSTATE_Human1.34361770
74SMAD1_18555785_Chip-Seq_ESCs_Mouse1.33775717
75MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.33094715
76IRF1_19129219_ChIP-ChIP_H3396_Human1.32016424
77CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.31109804
78CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30738366
79OCT4_21477851_ChIP-Seq_ESCs_Mouse1.30261197
80TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30009334
81KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.28384218
82PRDM14_20953172_ChIP-Seq_ESCs_Human1.27702541
83KDM2B_26808549_Chip-Seq_REH_Human1.25830831
84TCF4_22108803_ChIP-Seq_LS180_Human1.25810389
85RUNX2_22187159_ChIP-Seq_PCA_Human1.25409174
86SMAD4_21741376_ChIP-Seq_EPCs_Human1.25117879
87NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.25076168
88STAT1_17558387_ChIP-Seq_HELA_Human1.24877913
89KLF5_20875108_ChIP-Seq_MESCs_Mouse1.24584161
90HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.24509534
91MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.22393211
92TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.21577921
93FOXA1_21572438_ChIP-Seq_LNCaP_Human1.20040105
94GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.19965139
95DROSHA_22980978_ChIP-Seq_HELA_Human1.19585484
96SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.19539779
97NCOR_22424771_ChIP-Seq_293T_Human1.17270647
98SMAD3_21741376_ChIP-Seq_EPCs_Human1.15829907
99OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.15080445
100SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.14002751
101TCF4_23295773_ChIP-Seq_U87_Human1.13261130
102TOP2B_26459242_ChIP-Seq_MCF-7_Human1.12761040
103SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.12514395
104LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.11741100
105SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.11017460
106GATA3_21878914_ChIP-Seq_MCF-7_Human1.10588882
107TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.09136291
108REST_21632747_ChIP-Seq_MESCs_Mouse1.08865009
109EWS_26573619_Chip-Seq_HEK293_Human1.07765808
110CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.06765557
111CDX2_22108803_ChIP-Seq_LS180_Human1.06538549
112E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.05428839
113ETV2_25802403_ChIP-Seq_MESCs_Mouse1.05328595
114RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.05303616
115AR_20517297_ChIP-Seq_VCAP_Human1.05020881
116UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.04835605
117EGR1_23403033_ChIP-Seq_LIVER_Mouse1.04143137
118PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.02820713
119IGF1R_20145208_ChIP-Seq_DFB_Human1.02656424
120STAT3_23295773_ChIP-Seq_U87_Human1.02610547
121SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.02008280
122CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.01741107
123IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.01577317
124CBP_20019798_ChIP-Seq_JUKART_Human1.01577317
125AR_21572438_ChIP-Seq_LNCaP_Human1.01245317
126HOXB7_26014856_ChIP-Seq_BT474_Human1.00211950
127MYC_19829295_ChIP-Seq_ESCs_Human1.00074723
128CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.97557386
129LMO2_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.97335105
130SOX2_21211035_ChIP-Seq_LN229_Gbm0.97152007
131NOTCH1_21737748_ChIP-Seq_TLL_Human0.96494242
132PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.96419954
133ARNT_22903824_ChIP-Seq_MCF-7_Human0.96027271
134TBL1_22424771_ChIP-Seq_293T_Human0.95786018
135FLI1_21867929_ChIP-Seq_TH2_Mouse0.95569245
136EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.95501522
137PHF8_20622853_ChIP-Seq_HELA_Human0.95386117
138GF1B_26923725_Chip-Seq_HPCs_Mouse0.95140413
139SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.95138367
140LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95073823

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization7.50034976
2MP0003136_yellow_coat_color5.37735533
3MP0003195_calcinosis3.83295060
4MP0002653_abnormal_ependyma_morphology3.51272319
5MP0008877_abnormal_DNA_methylation3.50952957
6MP0003698_abnormal_male_reproductive3.49984929
7MP0001929_abnormal_gametogenesis3.20766307
8MP0005623_abnormal_meninges_morphology3.01338301
9MP0000569_abnormal_digit_pigmentation2.99401934
10MP0002837_dystrophic_cardiac_calcinosis2.63288801
11MP0002210_abnormal_sex_determination2.53516001
12MP0008057_abnormal_DNA_replication2.52129781
13MP0006292_abnormal_olfactory_placode2.48801882
14MP0003880_abnormal_central_pattern2.39022013
15MP0004381_abnormal_hair_follicle2.34968474
16MP0004885_abnormal_endolymph2.34563746
17MP0002102_abnormal_ear_morphology2.26550509
18MP0002160_abnormal_reproductive_system2.21741742
19MP0005646_abnormal_pituitary_gland2.15957972
20MP0000566_synostosis2.07831678
21MP0004043_abnormal_pH_regulation2.04538146
22MP0001188_hyperpigmentation1.97852110
23MP0001145_abnormal_male_reproductive1.91370412
24MP0008875_abnormal_xenobiotic_pharmacok1.83603898
25MP0009046_muscle_twitch1.82436085
26MP0002161_abnormal_fertility/fecundity1.80165522
27MP0008058_abnormal_DNA_repair1.78312292
28MP0000653_abnormal_sex_gland1.77809062
29MP0001984_abnormal_olfaction1.71327871
30MP0008872_abnormal_physiological_respon1.62240078
31MP0001501_abnormal_sleep_pattern1.61216051
32MP0001986_abnormal_taste_sensitivity1.61016273
33MP0002132_abnormal_respiratory_system1.58760020
34MP0003646_muscle_fatigue1.55658297
35MP0002277_abnormal_respiratory_mucosa1.43621490
36MP0001529_abnormal_vocalization1.42851915
37MP0005389_reproductive_system_phenotype1.42791410
38MP0002938_white_spotting1.40547796
39MP0009780_abnormal_chondrocyte_physiolo1.36413076
40MP0005084_abnormal_gallbladder_morpholo1.34266643
41MP0005423_abnormal_somatic_nervous1.32424476
42MP0002138_abnormal_hepatobiliary_system1.28902289
43MP0005409_darkened_coat_color1.28561522
44MP0004133_heterotaxia1.27533252
45MP0002876_abnormal_thyroid_physiology1.26523957
46MP0005171_absent_coat_pigmentation1.26397345
47MP0000778_abnormal_nervous_system1.21200466
48MP0002282_abnormal_trachea_morphology1.18571651
49MP0003011_delayed_dark_adaptation1.18323908
50MP0004147_increased_porphyrin_level1.17433747
51MP0002064_seizures1.16602681
52MP0003938_abnormal_ear_development1.15030748
53MP0001970_abnormal_pain_threshold1.14787657
54MP0010386_abnormal_urinary_bladder1.13829324
55MP0005551_abnormal_eye_electrophysiolog1.13235381
56MP0001905_abnormal_dopamine_level1.11783730
57MP0005075_abnormal_melanosome_morpholog1.11438335
58MP0002928_abnormal_bile_duct1.11357720
59MP0003252_abnormal_bile_duct1.10006850
60MP0010094_abnormal_chromosome_stability1.08684823
61MP0002733_abnormal_thermal_nociception1.07676695
62MP0000427_abnormal_hair_cycle1.06699311
63MP0000049_abnormal_middle_ear1.05468833
64MP0002067_abnormal_sensory_capabilities1.05044790
65MP0004742_abnormal_vestibular_system1.03003688
66MP0001765_abnormal_ion_homeostasis1.02956729
67MP0009250_abnormal_appendicular_skeleto1.01770628
68MP0002254_reproductive_system_inflammat1.01508660
69MP0000631_abnormal_neuroendocrine_gland1.01386351
70MP0001486_abnormal_startle_reflex1.01337376
71MP0000026_abnormal_inner_ear1.00694892
72MP0002229_neurodegeneration1.00388817
73MP0005386_behavior/neurological_phenoty1.00246000
74MP0004924_abnormal_behavior1.00246000
75MP0005253_abnormal_eye_physiology1.00154329
76MP0000372_irregular_coat_pigmentation0.99059745
77MP0003937_abnormal_limbs/digits/tail_de0.97898831
78MP0004142_abnormal_muscle_tone0.97571859
79MP0003635_abnormal_synaptic_transmissio0.97112731
80MP0003283_abnormal_digestive_organ0.96690265
81MP0004215_abnormal_myocardial_fiber0.95548158
82MP0000015_abnormal_ear_pigmentation0.95150086
83MP0009697_abnormal_copulation0.94531055
84MP0008004_abnormal_stomach_pH0.94448780
85MP0002909_abnormal_adrenal_gland0.94390413
86MP0006276_abnormal_autonomic_nervous0.94371831
87MP0002693_abnormal_pancreas_physiology0.93819245
88MP0001764_abnormal_homeostasis0.93151320
89MP0002249_abnormal_larynx_morphology0.92440273
90MP0003786_premature_aging0.92289238
91MP0002063_abnormal_learning/memory/cond0.91647910
92MP0003718_maternal_effect0.89470491
93MP0002734_abnormal_mechanical_nocicepti0.88942352
94MP0008995_early_reproductive_senescence0.87815181
95MP0003878_abnormal_ear_physiology0.87332967
96MP0005377_hearing/vestibular/ear_phenot0.87332967
97MP0002557_abnormal_social/conspecific_i0.86145455
98MP0002163_abnormal_gland_morphology0.84945024
99MP0001502_abnormal_circadian_rhythm0.84938650
100MP0002095_abnormal_skin_pigmentation0.84565213
101MP0004134_abnormal_chest_morphology0.83011216
102MP0005195_abnormal_posterior_eye0.82888530
103MP0008007_abnormal_cellular_replicative0.82602787
104MP0000230_abnormal_systemic_arterial0.82033187
105MP0002272_abnormal_nervous_system0.81865620
106MP0002638_abnormal_pupillary_reflex0.81846558
107MP0002572_abnormal_emotion/affect_behav0.81674770
108MP0002736_abnormal_nociception_after0.81667745
109MP0001177_atelectasis0.81398109
110MP0003950_abnormal_plasma_membrane0.81165569
111MP0003787_abnormal_imprinting0.81102588
112MP0004145_abnormal_muscle_electrophysio0.81009119
113MP0006072_abnormal_retinal_apoptosis0.80940874
114MP0005645_abnormal_hypothalamus_physiol0.80173388
115MP0004782_abnormal_surfactant_physiolog0.80108838
116MP0000383_abnormal_hair_follicle0.79116009
117MP0005647_abnormal_sex_gland0.78585919
118MP0001963_abnormal_hearing_physiology0.78533073
119MP0005379_endocrine/exocrine_gland_phen0.78010022
120MP0008789_abnormal_olfactory_epithelium0.76738722
121MP0005167_abnormal_blood-brain_barrier0.75693843
122MP0001485_abnormal_pinna_reflex0.73222248
123MP0009745_abnormal_behavioral_response0.72780063
124MP0002234_abnormal_pharynx_morphology0.72441476
125MP0001440_abnormal_grooming_behavior0.72032584
126MP0003879_abnormal_hair_cell0.69395971
127MP0005391_vision/eye_phenotype0.69265665
128MP0002752_abnormal_somatic_nervous0.67807511
129MP0001968_abnormal_touch/_nociception0.67782005
130MP0005174_abnormal_tail_pigmentation0.66977874
131MP0002735_abnormal_chemical_nociception0.66064965
132MP0001919_abnormal_reproductive_system0.64377247
133MP0005394_taste/olfaction_phenotype0.63737268
134MP0005499_abnormal_olfactory_system0.63737268
135MP0002133_abnormal_respiratory_system0.63272463
136MP0005388_respiratory_system_phenotype0.63272463
137MP0008932_abnormal_embryonic_tissue0.62605144
138MP0001119_abnormal_female_reproductive0.61492294
139MP0009379_abnormal_foot_pigmentation0.61070174
140MP0002116_abnormal_craniofacial_bone0.60751585

Predicted human phenotypes

RankGene SetZ-score
1Dynein arm defect of respiratory motile cilia (HP:0012255)9.24534690
2Absent/shortened dynein arms (HP:0200106)9.24534690
3Abnormal respiratory epithelium morphology (HP:0012253)8.87724993
4Abnormal respiratory motile cilium morphology (HP:0005938)8.87724993
5Rhinitis (HP:0012384)8.42728432
6Chronic bronchitis (HP:0004469)5.42977443
7Bronchiectasis (HP:0002110)5.07376572
8Nasal polyposis (HP:0100582)4.23055300
9Nephronophthisis (HP:0000090)4.12991592
10Infertility (HP:0000789)3.86108015
11Pancreatic fibrosis (HP:0100732)3.71065361
12True hermaphroditism (HP:0010459)3.51690920
13Recurrent sinusitis (HP:0011108)3.42654770
14Medial flaring of the eyebrow (HP:0010747)3.36195405
15Abnormality of the nasal mucosa (HP:0000433)3.29091461
16Abnormality of the renal medulla (HP:0100957)3.24555895
17Bronchitis (HP:0012387)3.11205939
18Abnormality of midbrain morphology (HP:0002418)3.03245368
19Molar tooth sign on MRI (HP:0002419)3.03245368
20Chronic sinusitis (HP:0011109)3.02704597
21Tubulointerstitial nephritis (HP:0001970)2.85103890
22Type II lissencephaly (HP:0007260)2.75936650
23Supernumerary spleens (HP:0009799)2.74877798
24Congenital stationary night blindness (HP:0007642)2.74589454
25Postaxial foot polydactyly (HP:0001830)2.72030665
26Congenital primary aphakia (HP:0007707)2.71376980
27Median cleft lip (HP:0000161)2.70791312
28Gait imbalance (HP:0002141)2.69352738
29Pancreatic cysts (HP:0001737)2.68783637
30Nephrogenic diabetes insipidus (HP:0009806)2.53270997
31Congenital hepatic fibrosis (HP:0002612)2.52329380
32Hyperventilation (HP:0002883)2.51592280
33Attenuation of retinal blood vessels (HP:0007843)2.46596981
34Aplasia/Hypoplasia of the tongue (HP:0010295)2.42382604
35Abnormal rod and cone electroretinograms (HP:0008323)2.40349802
36Progressive cerebellar ataxia (HP:0002073)2.39400838
37Renal cortical cysts (HP:0000803)2.38472813
38Recurrent otitis media (HP:0000403)2.38092842
39Polyuria (HP:0000103)2.37903680
40Fibular hypoplasia (HP:0003038)2.34742376
41Abolished electroretinogram (ERG) (HP:0000550)2.34567980
42Furrowed tongue (HP:0000221)2.33545904
43Optic neuritis (HP:0100653)2.30399199
44Retrobulbar optic neuritis (HP:0100654)2.30399199
45Gaze-evoked nystagmus (HP:0000640)2.30112974
46Occipital encephalocele (HP:0002085)2.25659640
47Preaxial hand polydactyly (HP:0001177)2.17868352
48Stomach cancer (HP:0012126)2.17077730
49Abnormality of the dental root (HP:0006486)2.14599948
50Taurodontia (HP:0000679)2.14599948
51Abnormality of permanent molar morphology (HP:0011071)2.14599948
52Cystic liver disease (HP:0006706)2.14202443
53Genital tract atresia (HP:0001827)2.14162315
54Pendular nystagmus (HP:0012043)2.13982521
55Hypothermia (HP:0002045)2.13186962
56Abnormality of molar morphology (HP:0011070)2.09608493
57Abnormality of molar (HP:0011077)2.09608493
58Methylmalonic acidemia (HP:0002912)2.08509476
59Poor coordination (HP:0002370)2.08184197
60Chromosomal breakage induced by crosslinking agents (HP:0003221)2.04953344
61Febrile seizures (HP:0002373)2.03094703
62Facial cleft (HP:0002006)2.01987236
63Vaginal atresia (HP:0000148)2.00652098
64Bile duct proliferation (HP:0001408)2.00428143
65Abnormal biliary tract physiology (HP:0012439)2.00428143
66Respiratory insufficiency due to defective ciliary clearance (HP:0200073)11.5017155
67Abnormal ciliary motility (HP:0012262)10.9628339
68Abnormal respiratory motile cilium physiology (HP:0012261)10.8574724
69Absent rod-and cone-mediated responses on ERG (HP:0007688)1.98852805
70Thyroid-stimulating hormone excess (HP:0002925)1.98433951
71Decreased circulating renin level (HP:0003351)1.98081602
72Abnormal urine output (HP:0012590)1.97239490
73Stage 5 chronic kidney disease (HP:0003774)1.95944232
74Postaxial hand polydactyly (HP:0001162)1.94012528
75Abnormality of dentin (HP:0010299)1.93586719
76Genetic anticipation (HP:0003743)1.91521032
77Abnormality of the dental pulp (HP:0006479)1.90006568
78Methylmalonic aciduria (HP:0012120)1.89679403
79Keratoconjunctivitis (HP:0001096)1.86429414
80Aplasia/Hypoplasia of the spleen (HP:0010451)1.85864856
81Male pseudohermaphroditism (HP:0000037)1.85041076
82Tubular atrophy (HP:0000092)1.84980931
83Bony spicule pigmentary retinopathy (HP:0007737)1.84953479
84Abnormality of macular pigmentation (HP:0008002)1.84507014
85Increased corneal curvature (HP:0100692)1.84471058
86Keratoconus (HP:0000563)1.84471058
87Chromsome breakage (HP:0040012)1.83617529
88Abnormality of renal excretion (HP:0011036)1.83153553
89Tubulointerstitial abnormality (HP:0001969)1.82753751
90Asplenia (HP:0001746)1.82457871
91Large for gestational age (HP:0001520)1.81689482
92Inability to walk (HP:0002540)1.81565336
93Aplasia/Hypoplasia of the lens (HP:0008063)1.77985532
94Cerebellar dysplasia (HP:0007033)1.76091285
95Anencephaly (HP:0002323)1.75866288
96Lissencephaly (HP:0001339)1.73857985
97Congenital sensorineural hearing impairment (HP:0008527)1.73059018
98Progressive inability to walk (HP:0002505)1.72644304
99Oculomotor apraxia (HP:0000657)1.72579045
100Hypophosphatemic rickets (HP:0004912)1.71582995
101Tubulointerstitial fibrosis (HP:0005576)1.70493303
10211 pairs of ribs (HP:0000878)1.68715698
103Hepatic necrosis (HP:0002605)1.66190813
104Orchitis (HP:0100796)1.64915479
105Absent speech (HP:0001344)1.64741245
106Broad-based gait (HP:0002136)1.63568663
107Chronic hepatic failure (HP:0100626)1.62442950
108Pachygyria (HP:0001302)1.62365978
109Aplasia/Hypoplasia of the fovea (HP:0008060)1.61395549
110Hypoplasia of the fovea (HP:0007750)1.61395549
111Ketosis (HP:0001946)1.61228737
112Multicystic kidney dysplasia (HP:0000003)1.60139856
113Focal seizures (HP:0007359)1.59975012
114Abnormality of the renal cortex (HP:0011035)1.59711462
115Microglossia (HP:0000171)1.56938379
116Aplasia/Hypoplasia of the fibula (HP:0006492)1.56901924
117Recurrent bronchitis (HP:0002837)1.56691604
118Abnormal spermatogenesis (HP:0008669)1.54144174
119Aplasia/Hypoplasia of the tibia (HP:0005772)1.53884774
120Aganglionic megacolon (HP:0002251)1.53776284
121Sclerocornea (HP:0000647)1.49657964
122Bell-shaped thorax (HP:0001591)1.49234756
123Abdominal situs inversus (HP:0003363)1.47467538
124Abnormality of abdominal situs (HP:0011620)1.47467538
125Nephropathy (HP:0000112)1.46298743
126Abnormal drinking behavior (HP:0030082)1.45791957
127Polydipsia (HP:0001959)1.45791957
128Astigmatism (HP:0000483)1.45542631
129Male infertility (HP:0003251)1.44870496
130Nephroblastoma (Wilms tumor) (HP:0002667)1.42848864
131Abnormality of renal resorption (HP:0011038)1.38655131
132Optic nerve hypoplasia (HP:0000609)1.37428083
133Decreased central vision (HP:0007663)1.36791479
134Atelectasis (HP:0100750)1.35356584
135Renal dysplasia (HP:0000110)1.34822570
136Azoospermia (HP:0000027)1.32927866
137Embryonal renal neoplasm (HP:0011794)1.32629099
138Hypodontia (HP:0000668)1.31894988
139Bifid tongue (HP:0010297)1.30258281
140Short tibia (HP:0005736)1.30237096
141Septo-optic dysplasia (HP:0100842)1.29254829
142Hypoplasia of the capital femoral epiphysis (HP:0003090)1.28875552
143Gonadotropin excess (HP:0000837)1.26406963
144Duplicated collecting system (HP:0000081)1.24695962
145Short ribs (HP:0000773)1.24495718
1463-Methylglutaconic aciduria (HP:0003535)1.24198545
147Retinitis pigmentosa (HP:0000510)1.20564121
148Meckel diverticulum (HP:0002245)1.19551640
149Oligohydramnios (HP:0001562)1.18052434
150Aplasia/Hypoplasia of the uvula (HP:0010293)1.17437705

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.79933632
2MAPK154.31170217
3PDK34.09353016
4PDK44.09353016
5PNCK3.86254561
6PDK23.01310780
7CASK3.00394446
8MAP4K22.78534954
9WNK32.49283657
10MAP3K42.30808784
11STK392.09993315
12EPHA32.00952363
13ACVR1B1.94739675
14PLK41.94109658
15TNIK1.86561582
16INSRR1.82909946
17SRPK11.81792536
18MAP2K71.79401455
19ZAK1.76234648
20TAOK31.74501984
21STK161.68483003
22NEK61.61754869
23MUSK1.58705507
24IRAK11.55263459
25CDK31.54718027
26VRK11.52033428
27BMPR1B1.48621988
28MKNK21.47918404
29WEE11.46301467
30PINK11.43987785
31WNK41.40212355
32ADRBK21.38114171
33TESK11.37847139
34IRAK41.37209111
35IRAK31.32057175
36GRK11.28348015
37TXK1.27580912
38PTK2B1.26157893
39BMPR21.25650200
40TTK1.21089026
41YES11.20114598
42PASK1.19061899
43PHKG21.18551686
44PHKG11.18551686
45PAK31.18049184
46CSNK1G21.12367889
47FGFR21.10229681
48CSNK1G31.08332604
49NTRK21.05717787
50NTRK31.04945596
51BRSK21.04733758
52EIF2AK21.04142758
53MAPK131.03286161
54CSNK1A1L1.02115874
55GRK71.01829922
56PBK1.01491733
57CSNK1G11.01424777
58DAPK21.01295884
59BCR0.98845042
60DYRK20.95719627
61FER0.90087175
62DYRK30.88735886
63WNK10.88284411
64PLK20.87878778
65ADRBK10.86553084
66CHEK20.85795700
67ICK0.83889652
68MKNK10.83591910
69STK38L0.82847728
70IRAK20.82407425
71MST40.82292646
72IKBKB0.81277507
73CDK190.78183738
74TRIM280.77072303
75AKT30.75954784
76PRPF4B0.75724072
77BCKDK0.73935162
78MARK10.73710899
79PLK10.71579610
80CAMKK10.69969105
81OXSR10.69642451
82NUAK10.69437859
83TIE10.68941725
84ITK0.67659131
85AURKA0.66859498
86MAPKAPK30.65728392
87KIT0.65645168
88PLK30.65178037
89CAMKK20.64963001
90CHUK0.64947615
91OBSCN0.63924003
92BUB10.63756609
93PRKCG0.63567189
94ERBB30.62996470
95CDC70.62053669
96PKN10.61391107
97PRKCI0.60034805
98PIK3CA0.58959958
99CLK10.58859588
100TEC0.57351995
101ATR0.57042738
102FGR0.56994975
103STK380.56780329
104STK30.56616482
105BRAF0.56367831
106MAPKAPK50.55709003
107STK110.54387606
108MARK30.53228177
109CCNB10.51521675
110SGK20.51171302
111CSNK1A10.47623761
112MAP2K40.47236452
113EPHA40.46855187
114NEK20.46537479
115RPS6KA50.46197765
116SGK4940.44423993
117SGK2230.44423993
118TLK10.43175707
119TNK20.42756431
120CAMK2A0.40774817
121PRKG10.40214947
122TSSK60.39846344
123PRKCE0.39655110
124ATM0.39269373
125PRKAA20.37139961
126SIK30.37036054
127PRKCA0.35921812
128MAP3K70.35367146
129MAP3K140.35137702
130BRD40.35020465
131TGFBR10.34530770
132NLK0.33098017
133CSNK2A10.33037633
134PRKACA0.32375199
135PRKCH0.31741995
136ERBB20.30734913
137RPS6KB10.30172822
138FGFR30.30088793
139DYRK1A0.28608741
140PRKCZ0.28388682
141IKBKE0.28331995
142CHEK10.27634407
143CSNK1D0.27259487
144NME10.27058234
145MOS0.26256244
146PIM20.25822139
147PRKCQ0.25326908
148MAP2K60.24090770

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007503.49449021
2Fanconi anemia pathway_Homo sapiens_hsa034603.20664549
3Huntingtons disease_Homo sapiens_hsa050163.09835959
4Basal transcription factors_Homo sapiens_hsa030222.96905152
5Maturity onset diabetes of the young_Homo sapiens_hsa049502.29550679
6Ether lipid metabolism_Homo sapiens_hsa005652.28944307
7Homologous recombination_Homo sapiens_hsa034402.25312229
8Oxidative phosphorylation_Homo sapiens_hsa001902.17050957
9Butanoate metabolism_Homo sapiens_hsa006502.11562855
10Linoleic acid metabolism_Homo sapiens_hsa005912.05307897
11Nitrogen metabolism_Homo sapiens_hsa009101.94562646
12Arachidonic acid metabolism_Homo sapiens_hsa005901.88404084
13Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.83255771
14alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.80789209
15Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.80023206
16Caffeine metabolism_Homo sapiens_hsa002321.72178202
17Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.68557012
18Nicotine addiction_Homo sapiens_hsa050331.66129260
19Tryptophan metabolism_Homo sapiens_hsa003801.65948035
20RNA polymerase_Homo sapiens_hsa030201.65490036
21Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.64545796
22Nucleotide excision repair_Homo sapiens_hsa034201.64479223
23Propanoate metabolism_Homo sapiens_hsa006401.62919741
24Protein export_Homo sapiens_hsa030601.62850110
25Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.60829867
26* Purine metabolism_Homo sapiens_hsa002301.59303519
27Sphingolipid metabolism_Homo sapiens_hsa006001.52745662
28Parkinsons disease_Homo sapiens_hsa050121.50807201
29* Pyrimidine metabolism_Homo sapiens_hsa002401.49929172
30Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.48981276
31Chemical carcinogenesis_Homo sapiens_hsa052041.47787887
32Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.47275831
33Proteasome_Homo sapiens_hsa030501.43853513
34Peroxisome_Homo sapiens_hsa041461.38668031
35ABC transporters_Homo sapiens_hsa020101.38443628
36Alzheimers disease_Homo sapiens_hsa050101.38332514
37Selenocompound metabolism_Homo sapiens_hsa004501.37978346
38Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.36549682
39Regulation of autophagy_Homo sapiens_hsa041401.33450189
40RNA degradation_Homo sapiens_hsa030181.32223347
41Phototransduction_Homo sapiens_hsa047441.31291529
42Ribosome_Homo sapiens_hsa030101.29755086
43Graft-versus-host disease_Homo sapiens_hsa053321.26531365
44Insulin secretion_Homo sapiens_hsa049111.25183162
45Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.22839482
46Non-homologous end-joining_Homo sapiens_hsa034501.22587062
47Taste transduction_Homo sapiens_hsa047421.20943039
48Primary bile acid biosynthesis_Homo sapiens_hsa001201.20571566
49SNARE interactions in vesicular transport_Homo sapiens_hsa041301.19190287
50DNA replication_Homo sapiens_hsa030301.17444596
51GABAergic synapse_Homo sapiens_hsa047271.14867102
52Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.13052266
53Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.10637653
54Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.02467190
55Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.01675041
56beta-Alanine metabolism_Homo sapiens_hsa004100.98552535
57Spliceosome_Homo sapiens_hsa030400.98132547
58Autoimmune thyroid disease_Homo sapiens_hsa053200.97859752
59Glutathione metabolism_Homo sapiens_hsa004800.96873723
60Dorso-ventral axis formation_Homo sapiens_hsa043200.93980992
61Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.93484972
62Mismatch repair_Homo sapiens_hsa034300.92800478
63Rheumatoid arthritis_Homo sapiens_hsa053230.92302056
64Cardiac muscle contraction_Homo sapiens_hsa042600.92297638
65Salivary secretion_Homo sapiens_hsa049700.91791731
66Steroid biosynthesis_Homo sapiens_hsa001000.91714062
67Glycerophospholipid metabolism_Homo sapiens_hsa005640.89410622
68Allograft rejection_Homo sapiens_hsa053300.87684548
69Cell cycle_Homo sapiens_hsa041100.87624478
70Base excision repair_Homo sapiens_hsa034100.86229354
71Amphetamine addiction_Homo sapiens_hsa050310.86134576
72Pyruvate metabolism_Homo sapiens_hsa006200.85915756
73Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.84643764
74Hedgehog signaling pathway_Homo sapiens_hsa043400.84587630
75Collecting duct acid secretion_Homo sapiens_hsa049660.83527216
76mRNA surveillance pathway_Homo sapiens_hsa030150.82999836
77Calcium signaling pathway_Homo sapiens_hsa040200.78616669
78Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.77030279
79Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.77003442
80Retinol metabolism_Homo sapiens_hsa008300.76492351
81Histidine metabolism_Homo sapiens_hsa003400.76465494
82Mineral absorption_Homo sapiens_hsa049780.76222768
83Primary immunodeficiency_Homo sapiens_hsa053400.72877992
84Basal cell carcinoma_Homo sapiens_hsa052170.70334795
85Glutamatergic synapse_Homo sapiens_hsa047240.70067281
86Serotonergic synapse_Homo sapiens_hsa047260.69078958
87Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.68818627
88Oocyte meiosis_Homo sapiens_hsa041140.68557515
89RNA transport_Homo sapiens_hsa030130.68172494
90Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.67946506
91Ovarian steroidogenesis_Homo sapiens_hsa049130.67032656
92Fatty acid elongation_Homo sapiens_hsa000620.66408305
93Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.66206136
94Wnt signaling pathway_Homo sapiens_hsa043100.66119773
95Cocaine addiction_Homo sapiens_hsa050300.65964801
96* Metabolic pathways_Homo sapiens_hsa011000.65497571
97Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.65113672
98Morphine addiction_Homo sapiens_hsa050320.60916911
99Sulfur metabolism_Homo sapiens_hsa009200.59765436
100Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.57666438
101Dopaminergic synapse_Homo sapiens_hsa047280.56786944
102Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.55585796
103Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.55020073
104cAMP signaling pathway_Homo sapiens_hsa040240.54147634
105Fatty acid biosynthesis_Homo sapiens_hsa000610.51639616
106Tyrosine metabolism_Homo sapiens_hsa003500.50824700
107Renin secretion_Homo sapiens_hsa049240.49057637
108Antigen processing and presentation_Homo sapiens_hsa046120.48731888
109Axon guidance_Homo sapiens_hsa043600.48457061
110Epstein-Barr virus infection_Homo sapiens_hsa051690.48290602
111Olfactory transduction_Homo sapiens_hsa047400.48100140
112Vascular smooth muscle contraction_Homo sapiens_hsa042700.47517364
113Synaptic vesicle cycle_Homo sapiens_hsa047210.46581808
114Long-term depression_Homo sapiens_hsa047300.46079666
115Steroid hormone biosynthesis_Homo sapiens_hsa001400.45444528
116Gastric acid secretion_Homo sapiens_hsa049710.44098307
117Hematopoietic cell lineage_Homo sapiens_hsa046400.44059648
118Oxytocin signaling pathway_Homo sapiens_hsa049210.43851650
119Intestinal immune network for IgA production_Homo sapiens_hsa046720.42360226
120Glycosaminoglycan degradation_Homo sapiens_hsa005310.42222203
121NOD-like receptor signaling pathway_Homo sapiens_hsa046210.42071813
122Fat digestion and absorption_Homo sapiens_hsa049750.41147225
123Fatty acid degradation_Homo sapiens_hsa000710.40830475
124p53 signaling pathway_Homo sapiens_hsa041150.40564617
125Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.38525159
126Other glycan degradation_Homo sapiens_hsa005110.37778620
127Circadian entrainment_Homo sapiens_hsa047130.36698678
128Jak-STAT signaling pathway_Homo sapiens_hsa046300.36237038
129Glycerolipid metabolism_Homo sapiens_hsa005610.34118252
130Inositol phosphate metabolism_Homo sapiens_hsa005620.33931824
131Asthma_Homo sapiens_hsa053100.33807357
132Circadian rhythm_Homo sapiens_hsa047100.33568261
133Pentose phosphate pathway_Homo sapiens_hsa000300.33440645
134Phagosome_Homo sapiens_hsa041450.32559521
135Vitamin digestion and absorption_Homo sapiens_hsa049770.31958859
136Type I diabetes mellitus_Homo sapiens_hsa049400.30542950

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