AK8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1multicellular organism reproduction (GO:0032504)9.96416324
2cell wall macromolecule metabolic process (GO:0044036)9.85601093
3cell wall macromolecule catabolic process (GO:0016998)9.85601093
4regulation of cilium movement (GO:0003352)9.84478371
5sperm-egg recognition (GO:0035036)9.75025093
6acrosome assembly (GO:0001675)9.48570305
7plasma membrane fusion (GO:0045026)9.12669371
8epithelial cilium movement (GO:0003351)9.07836980
9motile cilium assembly (GO:0044458)8.93942769
10binding of sperm to zona pellucida (GO:0007339)8.75481967
11cell-cell recognition (GO:0009988)8.69618788
12spermatid development (GO:0007286)8.48253780
13cilium movement (GO:0003341)8.32367186
14reproduction (GO:0000003)8.27365523
15piRNA metabolic process (GO:0034587)7.51254534
16epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.15072959
17single fertilization (GO:0007338)7.06171054
18male meiosis (GO:0007140)6.65549893
19synaptonemal complex organization (GO:0070193)6.34780340
20microtubule bundle formation (GO:0001578)6.22331859
21primary alcohol catabolic process (GO:0034310)6.11794440
22organic cation transport (GO:0015695)6.11525502
23synaptonemal complex assembly (GO:0007130)6.05914506
24fertilization (GO:0009566)5.95084545
25negative regulation of inclusion body assembly (GO:0090084)5.92136088
26regulation of microtubule-based movement (GO:0060632)5.90640401
27sperm capacitation (GO:0048240)5.88685033
28vitamin transmembrane transport (GO:0035461)5.74999919
29spermatogenesis (GO:0007283)5.66099904
30male gamete generation (GO:0048232)5.63784797
31* ventricular system development (GO:0021591)5.53970880
32centriole assembly (GO:0098534)5.50277541
33microtubule severing (GO:0051013)5.47839827
34gamete generation (GO:0007276)5.17533677
35response to xenobiotic stimulus (GO:0009410)5.09008853
36establishment of apical/basal cell polarity (GO:0035089)5.01476486
37ethanol metabolic process (GO:0006067)5.00806990
38microtubule depolymerization (GO:0007019)4.94313555
39protein localization to cilium (GO:0061512)4.88955287
40seminiferous tubule development (GO:0072520)4.79781155
41calcium ion-dependent exocytosis (GO:0017156)4.72094090
42germ cell development (GO:0007281)4.70785183
43regulation of inclusion body assembly (GO:0090083)4.70330384
44cellular process involved in reproduction in multicellular organism (GO:0022412)4.67880209
45DNA methylation involved in gamete generation (GO:0043046)4.51128044
46negative regulation of T cell differentiation in thymus (GO:0033085)4.50306061
47male meiosis I (GO:0007141)4.50081349
48establishment of monopolar cell polarity (GO:0061162)4.48687113
49establishment or maintenance of monopolar cell polarity (GO:0061339)4.48687113
50one-carbon compound transport (GO:0019755)4.44221952
51tolerance induction (GO:0002507)4.41283741
52lung epithelium development (GO:0060428)4.39837324
53protein polyglutamylation (GO:0018095)4.36979981
54diterpenoid biosynthetic process (GO:0016102)4.32910883
55pyrimidine-containing compound transmembrane transport (GO:0072531)4.29709577
56regulation of interleukin-5 production (GO:0032674)4.23608240
57cell projection assembly (GO:0030031)4.23184710
58microtubule polymerization or depolymerization (GO:0031109)4.19251114
59glomerular epithelial cell development (GO:0072310)4.16207035
60multicellular organismal reproductive process (GO:0048609)4.09883631
61positive regulation of tolerance induction (GO:0002645)4.09841218
62chromosome condensation (GO:0030261)4.07588421
63cell recognition (GO:0008037)4.07483095
64regulation of response to osmotic stress (GO:0047484)4.07135178
65chromosome organization involved in meiosis (GO:0070192)4.00071893
66meiotic nuclear division (GO:0007126)3.87999140
67regulation of interleukin-13 production (GO:0032656)3.87405543
68DNA packaging (GO:0006323)3.84142588
69negative regulation of immunoglobulin mediated immune response (GO:0002890)3.82360308
70negative regulation of B cell mediated immunity (GO:0002713)3.82360308
71left/right pattern formation (GO:0060972)3.81841552
72glycerol ether metabolic process (GO:0006662)3.75074919
73centriole replication (GO:0007099)3.73992969
74meiotic cell cycle (GO:0051321)3.68146346
75ethanol oxidation (GO:0006069)3.54912630
76negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.51414311
77meiosis I (GO:0007127)3.48425373
78lateral ventricle development (GO:0021670)3.46703477
79establishment of tissue polarity (GO:0007164)3.45906907
80establishment of planar polarity (GO:0001736)3.45906907
81ether metabolic process (GO:0018904)3.42958206
82spermatid nucleus differentiation (GO:0007289)3.38454421
83axoneme assembly (GO:0035082)3.29732525
84multicellular organismal development (GO:0007275)3.29379486
85genitalia morphogenesis (GO:0035112)3.25544463
86negative regulation of humoral immune response (GO:0002921)3.25075202
87regulation of germinal center formation (GO:0002634)3.24909104
88glutathione derivative metabolic process (GO:1901685)3.23888635
89glutathione derivative biosynthetic process (GO:1901687)3.23888635
90sequestering of actin monomers (GO:0042989)3.23354666
91calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.22084294
92cytoplasmic microtubule organization (GO:0031122)3.14787335
93regulation of tolerance induction (GO:0002643)3.13280918
94RNA destabilization (GO:0050779)3.12879790
95retinoic acid metabolic process (GO:0042573)3.10541414
96determination of left/right symmetry (GO:0007368)3.09173329
97cilium organization (GO:0044782)3.08803585
98* nucleoside diphosphate phosphorylation (GO:0006165)3.06737282
99intraciliary transport (GO:0042073)3.06490186
100terpenoid biosynthetic process (GO:0016114)3.02455412
101glycolytic process (GO:0006096)3.01245461
102reactive oxygen species biosynthetic process (GO:1903409)3.00560922
103cilium assembly (GO:0042384)2.98989140
104lateral sprouting from an epithelium (GO:0060601)2.98650237
105smoothened signaling pathway (GO:0007224)2.96374175
106determination of bilateral symmetry (GO:0009855)2.95593527
107polyketide metabolic process (GO:0030638)2.94575014
108doxorubicin metabolic process (GO:0044598)2.94575014
109daunorubicin metabolic process (GO:0044597)2.94575014
110positive regulation of smoothened signaling pathway (GO:0045880)2.93747435
111regulation of podosome assembly (GO:0071801)2.89285315
112chaperone-mediated protein complex assembly (GO:0051131)2.87868364
113specification of symmetry (GO:0009799)2.87610486
114peptidyl-glutamic acid modification (GO:0018200)2.86495208
115nuclear pore complex assembly (GO:0051292)2.84635836
116microtubule-based movement (GO:0007018)2.84060614
117carnitine metabolic process (GO:0009437)2.83213095
118aldehyde catabolic process (GO:0046185)2.78705379
119cellular component assembly involved in morphogenesis (GO:0010927)2.78360587
120microtubule-based process (GO:0007017)2.78138428
121RNA localization (GO:0006403)2.77468591
122cilium morphogenesis (GO:0060271)2.76106830
123membrane protein intracellular domain proteolysis (GO:0031293)2.74138993
124transepithelial transport (GO:0070633)2.73043618
125nucleus organization (GO:0006997)2.69102245
126natural killer cell mediated cytotoxicity (GO:0042267)2.69038071
127natural killer cell mediated immunity (GO:0002228)2.69038071
128interferon-gamma secretion (GO:0072643)2.68779816
129organelle assembly (GO:0070925)2.67866617
130regulation of spindle checkpoint (GO:0090231)2.65801915
131mitochondrion degradation (GO:0000422)2.63970086
132gene silencing by RNA (GO:0031047)2.62547735
133single strand break repair (GO:0000012)2.61636049
134regulation of cilium assembly (GO:1902017)2.60352393
135polyol catabolic process (GO:0046174)2.60270692
136protein localization to chromosome, centromeric region (GO:0071459)2.58374316
137lactate metabolic process (GO:0006089)2.57162558
138retinal rod cell development (GO:0046548)2.56978934
139exogenous drug catabolic process (GO:0042738)2.55412409
140hydrogen peroxide catabolic process (GO:0042744)2.53736125
141ear development (GO:0043583)2.53012161
142phosphatidylethanolamine biosynthetic process (GO:0006646)2.52825766
143heart looping (GO:0001947)2.51962780
144GTP biosynthetic process (GO:0006183)2.51857076
145primary alcohol metabolic process (GO:0034308)2.50102561
146left/right axis specification (GO:0070986)2.50050372
147embryonic camera-type eye development (GO:0031076)2.49827976
148excretion (GO:0007588)2.49585062
149phosphatidylethanolamine metabolic process (GO:0046337)2.49520611
150glutathione metabolic process (GO:0006749)2.49116877
151monoubiquitinated protein deubiquitination (GO:0035520)2.48747530
152muscle organ morphogenesis (GO:0048644)2.48406842
153pore complex assembly (GO:0046931)2.47644157
154L-ascorbic acid metabolic process (GO:0019852)2.46006884
155protein refolding (GO:0042026)2.45835283
156O-glycan processing (GO:0016266)2.45398018
157hydrogen peroxide biosynthetic process (GO:0050665)2.45066638
158amyloid precursor protein catabolic process (GO:0042987)2.42843757
159regulation of microtubule depolymerization (GO:0031114)2.42621410
160regulation of cytokine production involved in inflammatory response (GO:1900015)2.40087855
161heterochromatin organization (GO:0070828)2.38872660
162retinol metabolic process (GO:0042572)2.37098993
163hyperosmotic salinity response (GO:0042538)2.36521664
164fusion of sperm to egg plasma membrane (GO:0007342)12.1466350
165sperm motility (GO:0030317)11.7759379
166cilium or flagellum-dependent cell motility (GO:0001539)10.5818547
167acrosome reaction (GO:0007340)10.2934760
168axonemal dynein complex assembly (GO:0070286)10.1545866

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse9.44389365
2BP1_19119308_ChIP-ChIP_Hs578T_Human4.11283235
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.97408883
4DROSHA_22980978_ChIP-Seq_HELA_Human3.12102465
5FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.84302254
6EZH2_22144423_ChIP-Seq_EOC_Human2.75790744
7TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.67635091
8TRIM28_21343339_ChIP-Seq_HEK293_Human2.48308182
9VDR_22108803_ChIP-Seq_LS180_Human2.31990404
10PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse2.28871175
11IRF8_21731497_ChIP-ChIP_J774_Mouse2.26874995
12GATA1_26923725_Chip-Seq_HPCs_Mouse2.25496230
13ELK4_26923725_Chip-Seq_MESODERM_Mouse2.12733075
14SMC4_20622854_ChIP-Seq_HELA_Human2.11796170
15BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.08520484
16CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.92515350
17FLI1_27457419_Chip-Seq_LIVER_Mouse1.89548927
18GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.89281527
19IRF8_22096565_ChIP-ChIP_GC-B_Human1.88315046
20CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.85420432
21PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.82014676
22RUNX1_27514584_Chip-Seq_MCF-7_Human1.79279178
23CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.76677556
24TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.67061330
25SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.66124157
26AHR_22903824_ChIP-Seq_MCF-7_Human1.63730507
27EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.62523641
28ZNF263_19887448_ChIP-Seq_K562_Human1.62142102
29MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.62080669
30TP63_22573176_ChIP-Seq_HFKS_Human1.61768094
31FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.60940461
32IRF8_27001747_Chip-Seq_BMDM_Mouse1.60471817
33TDRD3_21172665_ChIP-Seq_MCF-7_Human1.57574181
34PCGF2_27294783_Chip-Seq_ESCs_Mouse1.56432699
35STAT6_21828071_ChIP-Seq_BEAS2B_Human1.55819763
36P68_20966046_ChIP-Seq_HELA_Human1.54316205
37CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.54068725
38SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.51812514
39KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.51131736
40ESR2_21235772_ChIP-Seq_MCF-7_Human1.51120958
41ESR1_20079471_ChIP-ChIP_T-47D_Human1.49667656
42ARNT_22903824_ChIP-Seq_MCF-7_Human1.47111047
43GATA3_21867929_ChIP-Seq_CD8_Mouse1.44861114
44CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.44152487
45KLF5_25053715_ChIP-Seq_YYC3_Human1.43761292
46PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.43520553
47ELF1_20517297_ChIP-Seq_JURKAT_Human1.43418032
48KAP1_22055183_ChIP-Seq_ESCs_Mouse1.42953679
49PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.41046876
50Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.39724388
51FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.38683658
52CTCF_27219007_Chip-Seq_Bcells_Human1.37495006
53STAT1_17558387_ChIP-Seq_HELA_Human1.37296270
54MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.36417585
55EZH2_27294783_Chip-Seq_ESCs_Mouse1.34502398
56PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.34142508
57NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.33660769
58SOX2_22085726_ChIP-Seq_NPCs_Mouse1.32795979
59GATA3_21867929_ChIP-Seq_TH1_Mouse1.31586973
60SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.31330153
61RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.31094678
62FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.31087646
63SPI1_26923725_Chip-Seq_HPCs_Mouse1.30701632
64CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.29714287
65* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.28573252
66KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.27280071
67KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.27280071
68KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.27280071
69ESR1_21235772_ChIP-Seq_MCF-7_Human1.26881499
70SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.25461358
71P300_27268052_Chip-Seq_Bcells_Human1.25299223
72E2F1_20622854_ChIP-Seq_HELA_Human1.22918122
73GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22795473
74PCGF2_27294783_Chip-Seq_NPCs_Mouse1.21907261
75TP63_23658742_ChIP-Seq_EP156T_Human1.20739456
76TP53_18474530_ChIP-ChIP_U2OS_Human1.20590519
77YY1_22570637_ChIP-Seq_MALME-3M_Human1.20049002
78PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.19696266
79STAT1_20625510_ChIP-Seq_HELA_Human1.19342689
80PIAS1_25552417_ChIP-Seq_VCAP_Human1.19103229
81TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.18891333
82TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.18734886
83NR3C1_21868756_ChIP-Seq_MCF10A_Human1.18415836
84ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.18180083
85LXR_22292898_ChIP-Seq_THP-1_Human1.18180017
86RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.16439406
87FOXM1_26456572_ChIP-Seq_MCF-7_Human1.16127513
88RUNX1_26923725_Chip-Seq_HPCs_Mouse1.16047402
89BCOR_27268052_Chip-Seq_Bcells_Human1.15944390
90P63_26484246_Chip-Seq_KERATINOCYTES_Human1.15257854
91NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.15009299
92ETV1_20927104_ChIP-Seq_GIST48_Human1.14648444
93TAL1_26923725_Chip-Seq_HPCs_Mouse1.13155078
94ERA_21632823_ChIP-Seq_H3396_Human1.12864496
95SMRT_27268052_Chip-Seq_Bcells_Human1.12730796
96MYC_19829295_ChIP-Seq_ESCs_Human1.12017088
97ESET_19884257_ChIP-Seq_ESCs_Mouse1.11852669
98CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.11779433
99WDR5_24793694_ChIP-Seq_LNCAP_Human1.11766011
100PHF8_20622854_ChIP-Seq_HELA_Human1.10122515
101RXRA_24833708_ChIP-Seq_LIVER_Mouse1.08559758
102SOX2_27498859_Chip-Seq_STOMACH_Mouse1.07607192
103SOX2_21211035_ChIP-Seq_LN229_Human1.07474503
104PHF8_20622853_ChIP-Seq_HELA_Human1.07264283
105EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.06821833
106NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.06479478
107PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.06116338
108GF1_26923725_Chip-Seq_HPCs_Mouse1.06114198
109ERG_20517297_ChIP-Seq_VCAP_Human1.06105135
110P53_21459846_ChIP-Seq_SAOS-2_Human1.06087874
111RAD21_21589869_ChIP-Seq_MESCs_Mouse1.05812399
112IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.05644243
113CBP_20019798_ChIP-Seq_JUKART_Human1.05644243
114LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.05438479
115RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.05361841
116SUZ12_27294783_Chip-Seq_ESCs_Mouse1.05298555
117VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.04872311
118RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.04663508
119HNFA_21074721_ChIP-Seq_CACO-2_Human1.04297447
120TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03949935
121GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.03768364
122TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.03656728
123RNF2_27304074_Chip-Seq_NSC_Mouse1.03609098
124CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03269426
125RBPJ_21746931_ChIP-Seq_IB4_Human1.03053418
126CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.02344297
127AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.01357240
128REST_21632747_ChIP-Seq_MESCs_Mouse1.00996491
129PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.00817706
130LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.00553569
131TOP2B_26459242_ChIP-Seq_MCF-7_Human1.00114419
132CTCF_20526341_ChIP-Seq_ESCs_Human0.99921771
133CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.97754632
134OCT4_20526341_ChIP-Seq_ESCs_Human0.97672815
135RARA_24833708_ChIP-Seq_LIVER_Mouse0.97572862
136SA1_27219007_Chip-Seq_ERYTHROID_Human0.97505584
137NANOG_20526341_ChIP-Seq_ESCs_Human0.97413503
138STAT3_18555785_ChIP-Seq_MESCs_Mouse0.96996201
139CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.96631522
140E2F1_17053090_ChIP-ChIP_MCF-7_Human0.96258299
141SOX2_20726797_ChIP-Seq_SW620_Human0.95490893
142SRY_22984422_ChIP-ChIP_TESTIS_Rat0.95230822
143* SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.94953620
144EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.94455541
145TET1_21451524_ChIP-Seq_MESCs_Mouse0.94242681
146GATA1_19941827_ChIP-Seq_MEL86_Mouse0.93890991
147SMAD4_21741376_ChIP-Seq_EPCs_Human0.93108968
148CTBP1_25329375_ChIP-Seq_LNCAP_Human0.93008836
149MYC_27129775_Chip-Seq_CORNEA_Mouse0.92619999
150BCL6_27268052_Chip-Seq_Bcells_Human0.91210592
151CBX2_22325352_ChIP-Seq_293T-Rex_Human0.91027467
152EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.90113677
153GATA6_21074721_ChIP-Seq_CACO-2_Human0.89959870
154CEBPB_22108803_ChIP-Seq_LS180_Human0.89672480
155CREB1_26743006_Chip-Seq_LNCaP_Human0.89325818
156MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.89237766
157P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.89187820
158SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.89019841
159CTCF_26484167_Chip-Seq_Bcells_Mouse0.89014720
160IKZF1_21737484_ChIP-ChIP_HCT116_Human0.88751191
161FLI1_21867929_ChIP-Seq_CD8_Mouse0.88092616
162RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.87805389
163LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.87791492
164BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human0.87210303
165GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.86854032
166JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.86739993
167SPI1_20517297_ChIP-Seq_HL60_Human0.86456597
168SA1_27219007_Chip-Seq_Bcells_Human0.86117274
169FOXA1_25329375_ChIP-Seq_VCAP_Human0.85962639
170FOXA1_27270436_Chip-Seq_PROSTATE_Human0.85962639
171FOXA1_25552417_ChIP-Seq_VCAP_Human0.84519598
172CTBP2_25329375_ChIP-Seq_LNCAP_Human0.84316361
173SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.82783814

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008875_abnormal_xenobiotic_pharmacok6.04056481
2MP0003698_abnormal_male_reproductive4.91208966
3MP0001929_abnormal_gametogenesis4.42538975
4MP0002653_abnormal_ependyma_morphology3.45976382
5MP0004133_heterotaxia3.39466906
6MP0000566_synostosis3.12427411
7MP0008877_abnormal_DNA_methylation3.09103513
8MP0008789_abnormal_olfactory_epithelium3.04578035
9MP0003878_abnormal_ear_physiology2.78936251
10MP0005377_hearing/vestibular/ear_phenot2.78936251
11MP0001984_abnormal_olfaction2.78532533
12MP0002210_abnormal_sex_determination2.77567600
13MP0009780_abnormal_chondrocyte_physiolo2.69866647
14MP0006082_CNS_inflammation2.68949001
15MP0002161_abnormal_fertility/fecundity2.62842754
16MP0001145_abnormal_male_reproductive2.36409246
17MP0003011_delayed_dark_adaptation2.25058034
18MP0005083_abnormal_biliary_tract2.11563515
19MP0001346_abnormal_lacrimal_gland2.10068504
20MP0010030_abnormal_orbit_morphology2.07661455
21MP0005410_abnormal_fertilization13.8902000
22MP0000653_abnormal_sex_gland1.89084831
23MP0003183_abnormal_peptide_metabolism1.82908255
24MP0001835_abnormal_antigen_presentation1.79798810
25MP0009379_abnormal_foot_pigmentation1.68883675
26MP0005670_abnormal_white_adipose1.64174575
27MP0000383_abnormal_hair_follicle1.62955466
28MP0005248_abnormal_Harderian_gland1.61165261
29MP0002332_abnormal_exercise_endurance1.55958778
30MP0003436_decreased_susceptibility_to1.54521452
31MP0002249_abnormal_larynx_morphology1.52097963
32MP0003646_muscle_fatigue1.51304636
33MP0005257_abnormal_intraocular_pressure1.45601932
34MP0004858_abnormal_nervous_system1.37622585
35MP0010678_abnormal_skin_adnexa1.36796713
36MP0009785_altered_susceptibility_to1.31206505
37MP0002638_abnormal_pupillary_reflex1.31136689
38MP0002160_abnormal_reproductive_system1.29545551
39MP0004264_abnormal_extraembryonic_tissu1.27496626
40MP0003136_yellow_coat_color1.26964144
41MP0003656_abnormal_erythrocyte_physiolo1.23137571
42MP0002139_abnormal_hepatobiliary_system1.20713767
43MP0000026_abnormal_inner_ear1.19158495
44MP0002148_abnormal_hypersensitivity_rea1.18080838
45MP0002876_abnormal_thyroid_physiology1.16403082
46MP0000681_abnormal_thyroid_gland1.16197556
47MP0005623_abnormal_meninges_morphology1.14091615
48MP0002405_respiratory_system_inflammati1.13867901
49MP0008961_abnormal_basal_metabolism1.13648071
50MP0005499_abnormal_olfactory_system1.11030362
51MP0005394_taste/olfaction_phenotype1.11030362
52MP0005000_abnormal_immune_tolerance1.09012344
53MP0002734_abnormal_mechanical_nocicepti1.08437826
54MP0005646_abnormal_pituitary_gland1.06616174
55MP0005025_abnormal_response_to1.06247598
56MP0008004_abnormal_stomach_pH1.05148387
57MP0002168_other_aberrant_phenotype1.04673660
58MP0002234_abnormal_pharynx_morphology0.97722548
59MP0002419_abnormal_innate_immunity0.97534153
60MP0008057_abnormal_DNA_replication0.96694573
61MP0001879_abnormal_lymphatic_vessel0.96065072
62MP0002822_catalepsy0.95756046
63MP0005395_other_phenotype0.94466032
64MP0002132_abnormal_respiratory_system0.93731868
65MP0001485_abnormal_pinna_reflex0.93449107
66MP0002928_abnormal_bile_duct0.90627773
67MP0002254_reproductive_system_inflammat0.90251575
68MP0000049_abnormal_middle_ear0.90247968
69MP0002735_abnormal_chemical_nociception0.89302942
70MP0009046_muscle_twitch0.88592541
71MP0001270_distended_abdomen0.86938115
72MP0001963_abnormal_hearing_physiology0.85884937
73MP0001502_abnormal_circadian_rhythm0.83774228
74MP0003303_peritoneal_inflammation0.83690757
75MP0002229_neurodegeneration0.81649477
76MP0002909_abnormal_adrenal_gland0.80475346
77MP0002277_abnormal_respiratory_mucosa0.80352612
78MP0003890_abnormal_embryonic-extraembry0.79804453
79MP0001765_abnormal_ion_homeostasis0.79669036
80MP0005075_abnormal_melanosome_morpholog0.79607824
81MP0002452_abnormal_antigen_presenting0.79578076
82MP0002723_abnormal_immune_serum0.79356623
83MP0003718_maternal_effect0.76874534
84MP0001324_abnormal_eye_pigmentation0.76762714
85MP0003448_altered_tumor_morphology0.76205934
86MP0006035_abnormal_mitochondrial_morpho0.74929657
87MP0001293_anophthalmia0.74444233
88MP0009765_abnormal_xenobiotic_induced0.73743763
89MP0005164_abnormal_response_to0.70246159
90MP0000343_altered_response_to0.69924969
91MP0002098_abnormal_vibrissa_morphology0.69491812
92MP0000358_abnormal_cell_content/0.69367204
93MP0002233_abnormal_nose_morphology0.69139492
94MP0001299_abnormal_eye_distance/0.68048206
95MP0000955_abnormal_spinal_cord0.67774243
96MP0005165_increased_susceptibility_to0.67207241
97MP0005551_abnormal_eye_electrophysiolog0.66747072
98MP0009278_abnormal_bone_marrow0.66732863
99MP0003075_altered_response_to0.66245241
100MP0002282_abnormal_trachea_morphology0.65911384
101MP0005397_hematopoietic_system_phenotyp0.65855753
102MP0001545_abnormal_hematopoietic_system0.65855753
103MP0001790_abnormal_immune_system0.65005307
104MP0005387_immune_system_phenotype0.65005307
105MP0009643_abnormal_urine_homeostasis0.64399584
106MP0008469_abnormal_protein_level0.63857420
107MP0001819_abnormal_immune_cell0.63729945
108MP0002420_abnormal_adaptive_immunity0.61890226
109MP0010155_abnormal_intestine_physiology0.61849113
110MP0005167_abnormal_blood-brain_barrier0.61789516
111MP0003786_premature_aging0.61436429
112MP0005389_reproductive_system_phenotype0.60812155
113MP0003806_abnormal_nucleotide_metabolis0.60648668
114MP0003941_abnormal_skin_development0.60047615
115MP0005195_abnormal_posterior_eye0.59620314
116MP0002136_abnormal_kidney_physiology0.59512396
117MP0001727_abnormal_embryo_implantation0.59496404
118MP0001800_abnormal_humoral_immune0.58936267
119MP0009764_decreased_sensitivity_to0.58658809
120MP0004883_abnormal_blood_vessel0.58563428
121MP0004782_abnormal_surfactant_physiolog0.57490213
122MP0003172_abnormal_lysosome_physiology0.57243211
123MP0004043_abnormal_pH_regulation0.56516073
124MP0008995_early_reproductive_senescence0.56291058
125MP0010234_abnormal_vibrissa_follicle0.56286862
126MP0005310_abnormal_salivary_gland0.55986361
127MP0009115_abnormal_fat_cell0.55885481
128MP0002116_abnormal_craniofacial_bone0.54428822
129MP0001845_abnormal_inflammatory_respons0.54252968
130MP0001853_heart_inflammation0.54165714
131MP0005408_hypopigmentation0.52130367
132MP0000678_abnormal_parathyroid_gland0.51623105
133MP0005058_abnormal_lysosome_morphology0.51543846
134MP0005503_abnormal_tendon_morphology0.51375625
135MP0003453_abnormal_keratinocyte_physiol0.51375544
136MP0003634_abnormal_glial_cell0.50736626
137MP0000858_altered_metastatic_potential0.50617054
138MP0008007_abnormal_cellular_replicative0.50503593
139MP0005253_abnormal_eye_physiology0.50448149
140MP0001986_abnormal_taste_sensitivity0.50169568
141MP0000313_abnormal_cell_death0.49732754
142MP0005266_abnormal_metabolism0.49144807
143MP0002092_abnormal_eye_morphology0.49073152
144MP0005391_vision/eye_phenotype0.48992659
145MP0002998_abnormal_bone_remodeling0.48143065
146MP0005671_abnormal_response_to0.46950455
147MP0003122_maternal_imprinting0.46462314
148MP0005647_abnormal_sex_gland0.46004857
149MP0006292_abnormal_olfactory_placode0.45039548
150MP0000716_abnormal_immune_system0.44081020
151MP0004019_abnormal_vitamin_homeostasis0.43119455
152MP0008058_abnormal_DNA_repair0.42671933
153MP0001849_ear_inflammation0.42453123
154MP0006036_abnormal_mitochondrial_physio0.41865761
155MP0005166_decreased_susceptibility_to0.41148084
156MP0005636_abnormal_mineral_homeostasis0.40492339
157MP0009333_abnormal_splenocyte_physiolog0.40154885
158MP0003186_abnormal_redox_activity0.38531392
159MP0005319_abnormal_enzyme/_coenzyme0.37878736

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)8.99915929
2Abnormal respiratory motile cilium morphology (HP:0005938)7.91867933
3Abnormal respiratory epithelium morphology (HP:0012253)7.91867933
4Rhinitis (HP:0012384)7.80084860
5Chronic bronchitis (HP:0004469)7.44679741
6Abnormal ciliary motility (HP:0012262)7.00898610
7Nasal polyposis (HP:0100582)6.72535626
8Infertility (HP:0000789)5.56374126
9Abnormality of the nasal mucosa (HP:0000433)5.48208418
10Bronchitis (HP:0012387)4.50133188
11Bronchiectasis (HP:0002110)4.47877866
12Occipital encephalocele (HP:0002085)3.96138943
13Nephronophthisis (HP:0000090)3.68542964
14True hermaphroditism (HP:0010459)3.49958109
15Male infertility (HP:0003251)3.39704149
16Atelectasis (HP:0100750)3.18163456
17Recurrent sinusitis (HP:0011108)3.12531448
18Recurrent otitis media (HP:0000403)3.12099772
19Abnormality of midbrain morphology (HP:0002418)3.04186488
20Molar tooth sign on MRI (HP:0002419)3.04186488
21Impulsivity (HP:0100710)2.95689005
22Pancreatic cysts (HP:0001737)2.91850258
23Chronic otitis media (HP:0000389)2.88908645
24Abnormality of the lower motor neuron (HP:0002366)2.86068337
25Chronic hepatic failure (HP:0100626)2.75740161
26Abnormality of the renal medulla (HP:0100957)2.75147196
27Recurrent bronchitis (HP:0002837)2.53768819
28Medial flaring of the eyebrow (HP:0010747)2.50053274
29Recurrent gram-negative bacterial infections (HP:0005420)2.48825023
30Bell-shaped thorax (HP:0001591)2.47773686
31Hyperactive renin-angiotensin system (HP:0000841)2.43038839
32Dyschromatopsia (HP:0007641)2.42885352
33Upper motor neuron abnormality (HP:0002127)2.41948044
34Spastic tetraparesis (HP:0001285)2.36118443
35Tubular atrophy (HP:0000092)2.33598116
36Abnormal spermatogenesis (HP:0008669)2.31222479
37Bilateral microphthalmos (HP:0007633)2.25741046
38Bifid tongue (HP:0010297)2.21881794
39Recurrent abscess formation (HP:0002722)2.20678513
40Bile duct proliferation (HP:0001408)2.19589486
41Abnormal biliary tract physiology (HP:0012439)2.19589486
42Anencephaly (HP:0002323)2.15502624
43Amyotrophic lateral sclerosis (HP:0007354)2.14973738
44Aplasia/Hypoplasia of the tongue (HP:0010295)2.14076948
45Congenital hepatic fibrosis (HP:0002612)2.08037656
46Hemiparesis (HP:0001269)2.05881541
47Tubulointerstitial fibrosis (HP:0005576)2.04610982
48Tubulointerstitial abnormality (HP:0001969)2.02833230
49Respiratory insufficiency due to defective ciliary clearance (HP:0200073)12.9500581
50Dynein arm defect of respiratory motile cilia (HP:0012255)10.7986493
51Absent/shortened dynein arms (HP:0200106)10.7986493
52Oculomotor apraxia (HP:0000657)1.99540025
53Recurrent bacterial skin infections (HP:0005406)1.95129441
54Postaxial foot polydactyly (HP:0001830)1.93110627
55Facial cleft (HP:0002006)1.90574255
56Sclerocornea (HP:0000647)1.88222109
57Orchitis (HP:0100796)1.82946291
58Tubulointerstitial nephritis (HP:0001970)1.81249293
59Male pseudohermaphroditism (HP:0000037)1.77555338
60Impaired proprioception (HP:0010831)1.76522087
61Absent frontal sinuses (HP:0002688)1.75320212
62Eczematoid dermatitis (HP:0000976)1.73444412
63Postaxial hand polydactyly (HP:0001162)1.73103304
64Hypoplasia of the capital femoral epiphysis (HP:0003090)1.71729412
65Furrowed tongue (HP:0000221)1.70522427
66Sensory axonal neuropathy (HP:0003390)1.70064547
67Absent rod-and cone-mediated responses on ERG (HP:0007688)1.69105502
68Choroideremia (HP:0001139)1.68404945
69Abnormal gallbladder physiology (HP:0012438)1.64735941
70Cholecystitis (HP:0001082)1.64735941
71Congenital primary aphakia (HP:0007707)1.64401143
72Gonadotropin excess (HP:0000837)1.62713475
73Gait imbalance (HP:0002141)1.61106372
74Hemorrhage of the eye (HP:0011885)1.56823962
75Hand muscle atrophy (HP:0009130)1.56401674
76Short humerus (HP:0005792)1.55481892
77Supernumerary spleens (HP:0009799)1.55191453
78Azoospermia (HP:0000027)1.55077163
79Aplasia/Hypoplasia of the macula (HP:0008059)1.54947686
80Aplasia/Hypoplasia of the lens (HP:0008063)1.54885556
81Aplasia/Hypoplasia affecting the retina (HP:0008061)1.53996339
82Increased CSF protein (HP:0002922)1.52380344
83Renal salt wasting (HP:0000127)1.50967097
84Nephroblastoma (Wilms tumor) (HP:0002667)1.49431509
85Nephrogenic diabetes insipidus (HP:0009806)1.46686795
86Hypoplasia of the fovea (HP:0007750)1.45983238
87Aplasia/Hypoplasia of the fovea (HP:0008060)1.45983238
88Aplasia/hypoplasia of the humerus (HP:0006507)1.43786853
89Decreased central vision (HP:0007663)1.43677649
90Gingivitis (HP:0000230)1.43673954
91Aplasia/Hypoplasia of the spleen (HP:0010451)1.43094690
92Cystic liver disease (HP:0006706)1.42255087
93Short nail (HP:0001799)1.41932027
94Abnormality of the fovea (HP:0000493)1.41867063
95Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.41533223
96Asplenia (HP:0001746)1.41434733
97Abnormality of glycolipid metabolism (HP:0010969)1.41075036
98Abnormality of liposaccharide metabolism (HP:0010968)1.41075036
99Abnormality of glycosphingolipid metabolism (HP:0004343)1.41075036
100Preaxial hand polydactyly (HP:0001177)1.40710516
101Cone-rod dystrophy (HP:0000548)1.39793344
102Chronic sinusitis (HP:0011109)1.39210370
103Pancreatic fibrosis (HP:0100732)1.38412323
104Myositis (HP:0100614)1.38401722
105Abnormal rod and cone electroretinograms (HP:0008323)1.37669862
106Abnormality of the dental root (HP:0006486)1.37296626
107Taurodontia (HP:0000679)1.37296626
108Abnormality of permanent molar morphology (HP:0011071)1.37296626
109Median cleft lip (HP:0000161)1.37127916
110Loss of speech (HP:0002371)1.37010127
111J-shaped sella turcica (HP:0002680)1.35980353
112Personality changes (HP:0000751)1.35710008
113Decreased circulating renin level (HP:0003351)1.35506064
114Short thorax (HP:0010306)1.34641138
115Polydipsia (HP:0001959)1.34104653
116Abnormal drinking behavior (HP:0030082)1.34104653
117Embryonal renal neoplasm (HP:0011794)1.33704725
118Nephropathy (HP:0000112)1.33006578
119Deformed sella turcica (HP:0002681)1.32757834
120Hyperkalemia (HP:0002153)1.31692769
121Vaginal atresia (HP:0000148)1.29433776
122Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.28429440
123Absent epiphyses (HP:0010577)1.28429440
124Cleft eyelid (HP:0000625)1.28097924
125Genital tract atresia (HP:0001827)1.27838011
126Stage 5 chronic kidney disease (HP:0003774)1.27796880
127Heterotopia (HP:0002282)1.27660336
128Hyperaldosteronism (HP:0000859)1.23526555
129Fetal akinesia sequence (HP:0001989)1.16958963
130Poor coordination (HP:0002370)1.16616471
131Short femoral neck (HP:0100864)1.16223623
132Abnormality of molar (HP:0011077)1.15858060
133Abnormality of molar morphology (HP:0011070)1.15858060
134Abnormality of the dental pulp (HP:0006479)1.14396613
135Down-sloping shoulders (HP:0200021)1.12480152
136Broad distal phalanx of finger (HP:0009836)1.09726737
137Abnormality of the distal phalanges of the toes (HP:0010182)1.07766755
138Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.06389656
139Abnormality of chloride homeostasis (HP:0011422)1.06292923
140Aplasia of the musculature (HP:0100854)1.05288789
141Renal dysplasia (HP:0000110)1.03713400
142Retinitis pigmentosa (HP:0000510)1.02519353
143Abnormality of renin-angiotensin system (HP:0000847)1.01760175
144Abnormality of the frontal sinuses (HP:0002687)0.98823109
145Aplasia/Hypoplasia of the sacrum (HP:0008517)0.97530397
146Abnormality of dentin (HP:0010299)0.96775635
147Spinal muscular atrophy (HP:0007269)0.96532870
148Aplasia/Hypoplasia involving the sinuses (HP:0009120)0.96255339
149Disproportionate short-trunk short stature (HP:0003521)0.94742669

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK36.59768336
2PDK46.59768336
3TESK15.57461062
4PDK24.64420747
5PRKD34.11558124
6EPHA23.99893522
7TIE13.81495663
8ICK3.59410896
9CDK123.57544080
10GRK52.64894058
11RIPK42.40373684
12ADRBK21.99739017
13ERN11.99316943
14PTK2B1.98244178
15NME11.95254295
16WNK41.94829797
17GRK61.93098141
18GRK11.70236745
19MAPKAPK31.63243464
20SMG11.59659816
21MAPK151.53021221
22STK391.52326291
23EPHB11.51943645
24MAP3K31.51269398
25DYRK1B1.51215242
26WNK11.48615380
27CSF1R1.48224610
28NEK21.48181302
29STK381.46328433
30STK161.43018449
31INSRR1.43006380
32STK241.42889763
33GRK71.38447419
34MAP2K71.24813168
35TYRO31.19327451
36PNCK1.16617215
37TLK11.14425130
38TTK1.11474215
39LRRK21.11151754
40STK101.10918976
41BCR1.10389886
42MAP3K21.09762417
43PLK41.08261766
44PDK11.05440864
45MAP3K111.02920700
46DDR21.00400441
47LIMK10.96452344
48IRAK10.96271850
49MATK0.90958775
50CSK0.86253956
51STK30.81270224
52MAP3K40.79368376
53ARAF0.78154434
54MAP3K120.74248969
55TAOK10.72235316
56VRK20.71228247
57IRAK20.69963170
58PAK40.69606483
59MOS0.63895163
60TGFBR20.63366622
61PRKCI0.63235740
62MAPK70.62374746
63CHEK20.61392899
64MAP3K140.60949517
65PRKG20.60100674
66AURKA0.59997156
67TBK10.59786323
68PIM20.58561985
69MAP2K60.57680340
70ERBB20.57463560
71EPHA30.53230369
72TYK20.53081279
73PBK0.52817183
74DYRK30.52655625
75TRIB30.51795251
76MARK20.50196637
77PDPK10.49965630
78EEF2K0.48843375
79ABL20.47773614
80RIPK10.47062822
81MUSK0.46844414
82CAMKK10.44640358
83IRAK40.44424842
84MARK30.43171723
85CAMK2G0.42347937
86FER0.42077288
87PAK10.39276412
88NTRK10.39248626
89STK38L0.38414940
90EPHB20.35788256
91ADRBK10.35492212
92CDK90.35261808
93CDC42BPA0.33883090
94PRKCD0.33661144
95CSNK1G20.33447724
96RPS6KB20.33397402
97PIM10.32664413
98MAPKAPK50.31820382
99CHEK10.31570633
100NTRK20.31310799
101NEK90.31030462
102IKBKB0.30710110
103MAP3K10.29584258
104BLK0.29498333
105MAP3K100.28558717
106PLK10.28458326
107MAP4K10.27991604
108PRKCQ0.27875412
109TGFBR10.27130334
110PRKAA20.26812121
111NEK60.26668612
112PINK10.26549218
113PRKCG0.26370578
114MAP3K70.24402251
115DYRK20.22920592
116MAP2K40.22813670
117CDK80.22355571
118CDK70.22093003
119CAMKK20.21789865
120MAP3K80.21629120
121PRKACA0.21495360
122SGK10.21047576
123MTOR0.21008011
124ATM0.20604116
125KIT0.20324037
126BCKDK0.19843281
127TESK20.19671851
128NME20.19539730
129MST40.18813991
130MAP3K130.18665902
131CAMK2A0.18319045
132CAMK40.18298112
133CSNK1A1L0.18021933
134RPS6KA20.17970742
135BMPR20.17706879
136ROCK20.17550408
137BMX0.17340020
138MAP4K20.16767961
139EPHA40.16438815
140CAMK1G0.16082653
141PRKCA0.15950460
142CSNK1G30.15490068
143IRAK30.15405349
144BRSK20.14528192
145SYK0.14487634
146EGFR0.14281945
147YES10.13074270
148MAPK130.12975414
149PIK3CG0.12299315
150WNK30.12147599
151MST1R0.11950897
152BMPR1B0.11445575
153ZAP700.10625331
154PRKAA10.09796284
155IGF1R0.09603205
156LYN0.09056656
157HCK0.08242253
158MAP3K50.08178605
159EIF2AK20.07911038
160PRKCZ0.07859604
161CHUK0.07854910
162PRKACG0.07761452
163JAK10.07721654
164BRAF0.07543539
165CLK10.05975575

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007504.65383328
2Phenylalanine metabolism_Homo sapiens_hsa003604.41003244
3Histidine metabolism_Homo sapiens_hsa003404.12211982
4Chemical carcinogenesis_Homo sapiens_hsa052043.92319176
5Drug metabolism - cytochrome P450_Homo sapiens_hsa009823.49893521
6Tyrosine metabolism_Homo sapiens_hsa003503.37313611
7Glycolysis / Gluconeogenesis_Homo sapiens_hsa000103.20519806
8beta-Alanine metabolism_Homo sapiens_hsa004103.11103592
9Glutathione metabolism_Homo sapiens_hsa004803.09857908
10alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.75676194
11Linoleic acid metabolism_Homo sapiens_hsa005912.72494557
12Fatty acid biosynthesis_Homo sapiens_hsa000612.56960098
13Legionellosis_Homo sapiens_hsa051342.45500673
14Fructose and mannose metabolism_Homo sapiens_hsa000512.38559587
15Collecting duct acid secretion_Homo sapiens_hsa049662.24796386
16Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.18689696
17Glycosaminoglycan degradation_Homo sapiens_hsa005312.11459978
18Graft-versus-host disease_Homo sapiens_hsa053321.99365356
19Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.90687642
20Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.90060542
21Retinol metabolism_Homo sapiens_hsa008301.78589753
22Arachidonic acid metabolism_Homo sapiens_hsa005901.76692018
23Basal transcription factors_Homo sapiens_hsa030221.73465968
24Rheumatoid arthritis_Homo sapiens_hsa053231.67091038
25Ether lipid metabolism_Homo sapiens_hsa005651.65508251
26Dorso-ventral axis formation_Homo sapiens_hsa043201.63942721
27Oxidative phosphorylation_Homo sapiens_hsa001901.61895854
28Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.58430348
29Pyruvate metabolism_Homo sapiens_hsa006201.58037243
30Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.57800968
31Caffeine metabolism_Homo sapiens_hsa002321.51633745
32Antigen processing and presentation_Homo sapiens_hsa046121.47126205
33Carbohydrate digestion and absorption_Homo sapiens_hsa049731.47121075
34Pentose phosphate pathway_Homo sapiens_hsa000301.46453105
35Other glycan degradation_Homo sapiens_hsa005111.45677338
36Fatty acid degradation_Homo sapiens_hsa000711.45075629
37Peroxisome_Homo sapiens_hsa041461.44138699
38Glucagon signaling pathway_Homo sapiens_hsa049221.38919931
39Phagosome_Homo sapiens_hsa041451.37496586
40Glycerophospholipid metabolism_Homo sapiens_hsa005641.36266246
41Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.35909199
42Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.33138455
43Leishmaniasis_Homo sapiens_hsa051401.32687577
44Mineral absorption_Homo sapiens_hsa049781.28181972
45Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.26180634
46Olfactory transduction_Homo sapiens_hsa047401.25355368
47Type I diabetes mellitus_Homo sapiens_hsa049401.24680769
48Salmonella infection_Homo sapiens_hsa051321.22830605
49Tuberculosis_Homo sapiens_hsa051521.22535138
50Notch signaling pathway_Homo sapiens_hsa043301.20989369
51Tight junction_Homo sapiens_hsa045301.19825884
52Synaptic vesicle cycle_Homo sapiens_hsa047211.15651054
53Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.15100727
54ABC transporters_Homo sapiens_hsa020101.13680583
55Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.12652991
56Glycerolipid metabolism_Homo sapiens_hsa005611.12409330
57Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.07822470
58Malaria_Homo sapiens_hsa051441.07214465
59Fanconi anemia pathway_Homo sapiens_hsa034601.05779661
60African trypanosomiasis_Homo sapiens_hsa051431.05376567
61Pentose and glucuronate interconversions_Homo sapiens_hsa000401.01757350
62Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.01639594
63Ribosome_Homo sapiens_hsa030100.96239438
64Lysosome_Homo sapiens_hsa041420.95930403
65Huntingtons disease_Homo sapiens_hsa050160.95339704
66Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.93787538
67Steroid hormone biosynthesis_Homo sapiens_hsa001400.92404674
68Influenza A_Homo sapiens_hsa051640.90687069
69PPAR signaling pathway_Homo sapiens_hsa033200.90577494
70Osteoclast differentiation_Homo sapiens_hsa043800.86830699
71Vibrio cholerae infection_Homo sapiens_hsa051100.86201437
72Inositol phosphate metabolism_Homo sapiens_hsa005620.85788765
73Parkinsons disease_Homo sapiens_hsa050120.81454311
74Hedgehog signaling pathway_Homo sapiens_hsa043400.81398133
75Selenocompound metabolism_Homo sapiens_hsa004500.81156703
76Alzheimers disease_Homo sapiens_hsa050100.80857127
77B cell receptor signaling pathway_Homo sapiens_hsa046620.79558404
78Oocyte meiosis_Homo sapiens_hsa041140.78154539
79Adipocytokine signaling pathway_Homo sapiens_hsa049200.75240914
80Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.74353386
81Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.73229921
82NF-kappa B signaling pathway_Homo sapiens_hsa040640.73063312
83Toll-like receptor signaling pathway_Homo sapiens_hsa046200.72979330
84Measles_Homo sapiens_hsa051620.69558551
85Galactose metabolism_Homo sapiens_hsa000520.69368573
86Salivary secretion_Homo sapiens_hsa049700.68720750
87Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.68183814
88Staphylococcus aureus infection_Homo sapiens_hsa051500.65429270
89Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.65379337
90Phosphatidylinositol signaling system_Homo sapiens_hsa040700.65243704
91Hepatitis C_Homo sapiens_hsa051600.65076186
92Toxoplasmosis_Homo sapiens_hsa051450.64296377
93mRNA surveillance pathway_Homo sapiens_hsa030150.62614069
94Amphetamine addiction_Homo sapiens_hsa050310.61506840
95Asthma_Homo sapiens_hsa053100.60903499
96Basal cell carcinoma_Homo sapiens_hsa052170.60789073
97Phototransduction_Homo sapiens_hsa047440.60371346
98RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.59461868
99Pertussis_Homo sapiens_hsa051330.59034468
100Renin secretion_Homo sapiens_hsa049240.58506754
101Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.58392721
102Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.58129652
103Propanoate metabolism_Homo sapiens_hsa006400.57066291
104Herpes simplex infection_Homo sapiens_hsa051680.56867991
105* Metabolic pathways_Homo sapiens_hsa011000.56295625
106Regulation of autophagy_Homo sapiens_hsa041400.55882723
107Arginine and proline metabolism_Homo sapiens_hsa003300.55462291
108Starch and sucrose metabolism_Homo sapiens_hsa005000.55454970
109Cardiac muscle contraction_Homo sapiens_hsa042600.55328522
110Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.54401282
111Nicotine addiction_Homo sapiens_hsa050330.53024964
112NOD-like receptor signaling pathway_Homo sapiens_hsa046210.52002350
113Allograft rejection_Homo sapiens_hsa053300.47388654
114Jak-STAT signaling pathway_Homo sapiens_hsa046300.47056298
115RNA transport_Homo sapiens_hsa030130.46705005
116Tryptophan metabolism_Homo sapiens_hsa003800.46647296
117Leukocyte transendothelial migration_Homo sapiens_hsa046700.46572392
118VEGF signaling pathway_Homo sapiens_hsa043700.46187874
119Taste transduction_Homo sapiens_hsa047420.45260208
120Primary bile acid biosynthesis_Homo sapiens_hsa001200.45149389
121Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.44515108
122Hematopoietic cell lineage_Homo sapiens_hsa046400.44168631
123Drug metabolism - other enzymes_Homo sapiens_hsa009830.43890113
124Circadian rhythm_Homo sapiens_hsa047100.43069365
125Renin-angiotensin system_Homo sapiens_hsa046140.42449635
126Carbon metabolism_Homo sapiens_hsa012000.41682136
127Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.40955450
128Steroid biosynthesis_Homo sapiens_hsa001000.40732423
129Endocytosis_Homo sapiens_hsa041440.40367153
130Central carbon metabolism in cancer_Homo sapiens_hsa052300.39903938
131Prion diseases_Homo sapiens_hsa050200.39560087
132Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.39320749
133Sphingolipid metabolism_Homo sapiens_hsa006000.38795234
134Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.38758090
135Estrogen signaling pathway_Homo sapiens_hsa049150.38224556
136Calcium signaling pathway_Homo sapiens_hsa040200.37218711
137TNF signaling pathway_Homo sapiens_hsa046680.36901413
138Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.36586023
139Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.36280601
140Cocaine addiction_Homo sapiens_hsa050300.34652572
141Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.34352679
142Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.34289721
143Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.34165016
144cAMP signaling pathway_Homo sapiens_hsa040240.34151599
145Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.33611509
146Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.33237928
147Sulfur relay system_Homo sapiens_hsa041220.32631698
148Insulin secretion_Homo sapiens_hsa049110.32203138
149Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.31018014
150Cyanoamino acid metabolism_Homo sapiens_hsa004600.30471516
151Transcriptional misregulation in cancer_Homo sapiens_hsa052020.28488764
152Intestinal immune network for IgA production_Homo sapiens_hsa046720.25823181
153Folate biosynthesis_Homo sapiens_hsa007900.22700885
154Choline metabolism in cancer_Homo sapiens_hsa052310.22558066
155Autoimmune thyroid disease_Homo sapiens_hsa053200.19883494
156Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.18112129
157Axon guidance_Homo sapiens_hsa043600.15413812
158Butanoate metabolism_Homo sapiens_hsa006500.14876195
159Nitrogen metabolism_Homo sapiens_hsa009100.13300236
160Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.12686456

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