AK2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Adenylate kinases are involved in regulating the adenine nucleotide composition within a cell by catalyzing the reversible transfer of phosphate groups among adenine nucleotides. Three isozymes of adenylate kinase, namely 1, 2, and 3, have been identified in vertebrates; this gene encodes isozyme 2. Expression of these isozymes is tissue-specific and developmentally regulated. Isozyme 2 is localized in the mitochondrial intermembrane space and may play a role in apoptosis. Mutations in this gene are the cause of reticular dysgenesis. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 1 and 2. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)5.45005754
2formation of translation preinitiation complex (GO:0001731)4.84192397
3nuclear pore organization (GO:0006999)4.71266780
4regulation of translational fidelity (GO:0006450)4.51086914
5ribosomal small subunit biogenesis (GO:0042274)4.32109057
6DNA replication initiation (GO:0006270)4.25878621
7mitotic chromosome condensation (GO:0007076)4.24584323
8erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.21140242
9L-phenylalanine metabolic process (GO:0006558)4.21140242
10glycine metabolic process (GO:0006544)4.14173270
11pore complex assembly (GO:0046931)4.13942088
12L-phenylalanine catabolic process (GO:0006559)4.13065991
13erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.13065991
14triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.08360838
15maturation of SSU-rRNA (GO:0030490)3.97734478
16proline biosynthetic process (GO:0006561)3.89926413
17serine family amino acid biosynthetic process (GO:0009070)3.86379925
18aromatic amino acid family catabolic process (GO:0009074)3.85647889
19cysteine metabolic process (GO:0006534)3.83003717
20telomere maintenance via recombination (GO:0000722)3.81640671
21urea metabolic process (GO:0019627)3.80457815
22urea cycle (GO:0000050)3.80457815
23alpha-linolenic acid metabolic process (GO:0036109)3.77153746
24COPI coating of Golgi vesicle (GO:0048205)3.73178314
25Golgi transport vesicle coating (GO:0048200)3.73178314
26glyoxylate metabolic process (GO:0046487)3.72364855
27mitotic sister chromatid segregation (GO:0000070)3.71555025
28mitotic nuclear envelope disassembly (GO:0007077)3.70226309
29ribosomal large subunit biogenesis (GO:0042273)3.68945586
30sulfur amino acid catabolic process (GO:0000098)3.67359958
31folic acid-containing compound biosynthetic process (GO:0009396)3.61253389
32serine family amino acid catabolic process (GO:0009071)3.59958674
33serine family amino acid metabolic process (GO:0009069)3.59439304
34indole-containing compound catabolic process (GO:0042436)3.59370263
35indolalkylamine catabolic process (GO:0046218)3.59370263
36tryptophan catabolic process (GO:0006569)3.59370263
37ribosome assembly (GO:0042255)3.58510725
38ribonucleoprotein complex biogenesis (GO:0022613)3.55612592
39kynurenine metabolic process (GO:0070189)3.55484161
40mitotic recombination (GO:0006312)3.52992522
41nitrogen cycle metabolic process (GO:0071941)3.52498048
42DNA topological change (GO:0006265)3.48011813
43sister chromatid segregation (GO:0000819)3.47454247
44negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.46153236
45establishment of integrated proviral latency (GO:0075713)3.45598015
46fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.44430236
47viral transcription (GO:0019083)3.42937304
48membrane disassembly (GO:0030397)3.42201969
49nuclear envelope disassembly (GO:0051081)3.42201969
50amino-acid betaine metabolic process (GO:0006577)3.41874411
51tryptophan metabolic process (GO:0006568)3.37735385
52ribosome biogenesis (GO:0042254)3.34264540
53translational termination (GO:0006415)3.32682400
54lysine metabolic process (GO:0006553)3.32331000
55lysine catabolic process (GO:0006554)3.32331000
56regulation of triglyceride catabolic process (GO:0010896)3.30593173
57tetrahydrofolate metabolic process (GO:0046653)3.27036843
58valine metabolic process (GO:0006573)3.26595876
59bile acid biosynthetic process (GO:0006699)3.26125572
60L-serine metabolic process (GO:0006563)3.25663992
61folic acid metabolic process (GO:0046655)3.24335648
62protein localization to chromosome, centromeric region (GO:0071459)3.24261691
63acylglycerol homeostasis (GO:0055090)3.19478358
64triglyceride homeostasis (GO:0070328)3.19478358
65regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.17785778
66homocysteine metabolic process (GO:0050667)3.16944960
67negative regulation of fibrinolysis (GO:0051918)3.16673095
68positive regulation of triglyceride lipase activity (GO:0061365)3.15361270
69positive regulation of lipoprotein lipase activity (GO:0051006)3.15361270
70imidazole-containing compound metabolic process (GO:0052803)3.15202803
71tRNA aminoacylation for protein translation (GO:0006418)3.14371303
72deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.14322537
73high-density lipoprotein particle remodeling (GO:0034375)3.13867880
74SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.12264403
75DNA replication checkpoint (GO:0000076)3.12162324
76nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.11663684
77translational initiation (GO:0006413)3.10465160
78viral mRNA export from host cell nucleus (GO:0046784)3.08431947
79regulation of mitochondrial translation (GO:0070129)3.07866799
80complement activation, alternative pathway (GO:0006957)3.07637800
81DNA duplex unwinding (GO:0032508)3.04913577
82negative regulation of cholesterol transport (GO:0032375)3.04645450
83negative regulation of sterol transport (GO:0032372)3.04645450
84tRNA aminoacylation (GO:0043039)3.04249170
85amino acid activation (GO:0043038)3.04249170
86protein maturation by protein folding (GO:0022417)3.02708665
87protein targeting to ER (GO:0045047)3.02433494
88nucleotide-excision repair, DNA gap filling (GO:0006297)3.02399679
89cotranslational protein targeting to membrane (GO:0006613)3.02296181
90one-carbon metabolic process (GO:0006730)3.02190955
91translational elongation (GO:0006414)3.01197015
92peptidyl-glutamic acid carboxylation (GO:0017187)2.99409408
93protein carboxylation (GO:0018214)2.99409408
94regulation of protein activation cascade (GO:2000257)2.99155908
95plasma lipoprotein particle clearance (GO:0034381)2.96109623
96regulation of translational termination (GO:0006449)2.95172167
97IMP metabolic process (GO:0046040)2.94794758
98protein localization to kinetochore (GO:0034501)2.94577858
99protein-lipid complex remodeling (GO:0034368)2.94077076
100macromolecular complex remodeling (GO:0034367)2.94077076
101plasma lipoprotein particle remodeling (GO:0034369)2.94077076
102negative regulation of mRNA processing (GO:0050686)2.93446993
103establishment of protein localization to endoplasmic reticulum (GO:0072599)2.92760229
104alpha-amino acid catabolic process (GO:1901606)2.91918384
105nucleobase biosynthetic process (GO:0046112)2.91810429
106aldehyde catabolic process (GO:0046185)2.91477053
107telomere maintenance via telomere lengthening (GO:0010833)2.91203029
108DNA geometric change (GO:0032392)2.90143122
109DNA strand elongation involved in DNA replication (GO:0006271)2.89870761
110aromatic amino acid family metabolic process (GO:0009072)2.89013407
111carnitine metabolic process (GO:0009437)2.88761349
112spliceosomal tri-snRNP complex assembly (GO:0000244)2.87163590
113regulation of cholesterol esterification (GO:0010872)2.86836119
114* nucleobase-containing small molecule interconversion (GO:0015949)2.86791458
115negative regulation of RNA splicing (GO:0033119)2.86626862
116protein localization to endoplasmic reticulum (GO:0070972)2.85148954
117bile acid metabolic process (GO:0008206)2.84763908
118folic acid-containing compound metabolic process (GO:0006760)2.83962162
119regulation of mitotic spindle organization (GO:0060236)2.83226647
120regulation of cholesterol homeostasis (GO:2000188)2.82626703
121regulation of fibrinolysis (GO:0051917)2.82562879
122DNA conformation change (GO:0071103)2.82083397
123pteridine-containing compound biosynthetic process (GO:0042559)2.81893492
124regulation of complement activation (GO:0030449)2.81688102
125ribosomal small subunit assembly (GO:0000028)2.80185175
126purine nucleobase biosynthetic process (GO:0009113)2.79950571
127viral life cycle (GO:0019058)2.79135484
128ethanol oxidation (GO:0006069)2.78247004
129DNA strand elongation (GO:0022616)2.76165287
130mitotic metaphase plate congression (GO:0007080)2.75817086
131nuclear envelope organization (GO:0006998)2.75717291
132chromosome condensation (GO:0030261)2.75242074
133regulation of translational elongation (GO:0006448)2.75131337
134rRNA processing (GO:0006364)2.74037578
135low-density lipoprotein particle clearance (GO:0034383)2.72459209
136negative regulation of fatty acid biosynthetic process (GO:0045717)2.71276398
137DNA deamination (GO:0045006)2.71240565
138telomere maintenance via semi-conservative replication (GO:0032201)2.70852790
139negative regulation of mRNA metabolic process (GO:1903312)2.69735278
140fatty acid beta-oxidation (GO:0006635)2.69714506
141cellular amino acid catabolic process (GO:0009063)2.69171669
142establishment of viral latency (GO:0019043)2.69162928
143NADH metabolic process (GO:0006734)2.68409870
144cellular protein complex disassembly (GO:0043624)2.68385229
145phospholipid efflux (GO:0033700)2.68338027
146plasma lipoprotein particle assembly (GO:0034377)2.65557967
147positive regulation of triglyceride metabolic process (GO:0090208)2.65093665
148regulation of RNA export from nucleus (GO:0046831)2.64245313
149mitotic sister chromatid cohesion (GO:0007064)2.64196663
150pentose-phosphate shunt (GO:0006098)2.63869676
151deoxyribonucleotide biosynthetic process (GO:0009263)2.63822654
152protoporphyrinogen IX metabolic process (GO:0046501)2.63092358
153DNA unwinding involved in DNA replication (GO:0006268)2.62865081
154reverse cholesterol transport (GO:0043691)2.62646831
155pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.62442674
156bile acid and bile salt transport (GO:0015721)2.62309440
157cholesterol homeostasis (GO:0042632)2.61522260
158rRNA metabolic process (GO:0016072)2.60641651
159nucleoside salvage (GO:0043174)2.60051711
160dosage compensation (GO:0007549)2.59983047
161peptidyl-arginine omega-N-methylation (GO:0035247)2.59830760
162oxaloacetate metabolic process (GO:0006107)2.59741049
163translation (GO:0006412)2.58941149
164proline metabolic process (GO:0006560)2.57839036
165fatty acid oxidation (GO:0019395)2.57163754
166sterol homeostasis (GO:0055092)2.56921484
167DNA ligation (GO:0006266)2.56576274
168pteridine-containing compound metabolic process (GO:0042558)2.55702268
169protein complex disassembly (GO:0043241)2.55670117
170pyridine nucleotide biosynthetic process (GO:0019363)2.55307066
171nicotinamide nucleotide biosynthetic process (GO:0019359)2.55307066
172tyrosine metabolic process (GO:0006570)2.55191151
173cellular component biogenesis (GO:0044085)2.54921170
174protein export from nucleus (GO:0006611)2.54501786
175IMP biosynthetic process (GO:0006188)2.54450999
176acetyl-CoA metabolic process (GO:0006084)2.54366225
177very-low-density lipoprotein particle assembly (GO:0034379)2.53771974
178primary alcohol catabolic process (GO:0034310)2.53119860
1792-oxoglutarate metabolic process (GO:0006103)2.53045824
180pinocytosis (GO:0006907)2.52842323
181cellular glucuronidation (GO:0052695)2.52827912
182NADPH regeneration (GO:0006740)2.52790904
183regulation of cholesterol storage (GO:0010885)2.51895083
184response to nitrosative stress (GO:0051409)2.51675395
185non-recombinational repair (GO:0000726)2.51380022

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.39877258
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.02561150
3* PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.69717208
4* RXR_22158963_ChIP-Seq_LIVER_Mouse3.37353390
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.28189163
6* PPARA_22158963_ChIP-Seq_LIVER_Mouse3.18589852
7MYC_18555785_ChIP-Seq_MESCs_Mouse3.10206095
8EGR1_23403033_ChIP-Seq_LIVER_Mouse2.90629034
9CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.75272809
10FOXM1_23109430_ChIP-Seq_U2OS_Human2.40237475
11CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.34864869
12* LXR_22158963_ChIP-Seq_LIVER_Mouse2.34385888
13E2F4_17652178_ChIP-ChIP_JURKAT_Human2.27742745
14FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.19761818
15* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.14211822
16KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.01263794
17* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.98366845
18MYC_19079543_ChIP-ChIP_MESCs_Mouse1.96126940
19AR_21909140_ChIP-Seq_LNCAP_Human1.89943785
20ELF1_17652178_ChIP-ChIP_JURKAT_Human1.89663925
21EST1_17652178_ChIP-ChIP_JURKAT_Human1.89313749
22THAP11_20581084_ChIP-Seq_MESCs_Mouse1.87586565
23JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.80660175
24* CREB1_15753290_ChIP-ChIP_HEK293T_Human1.77755378
25ZNF263_19887448_ChIP-Seq_K562_Human1.76724781
26TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.74675256
27ETS1_20019798_ChIP-Seq_JURKAT_Human1.72157521
28NELFA_20434984_ChIP-Seq_ESCs_Mouse1.71146807
29FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.68835116
30GABP_17652178_ChIP-ChIP_JURKAT_Human1.68039255
31HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.63759019
32STAT3_1855785_ChIP-Seq_MESCs_Mouse1.63489553
33XRN2_22483619_ChIP-Seq_HELA_Human1.62091265
34* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.57881556
35DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.55591262
36IRF8_22096565_ChIP-ChIP_GC-B_Human1.52624366
37NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.52604799
38* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.51170478
39DCP1A_22483619_ChIP-Seq_HELA_Human1.45314693
40YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.45149830
41MYC_22102868_ChIP-Seq_BL_Human1.42504916
42CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.40236621
43VDR_23849224_ChIP-Seq_CD4+_Human1.40228958
44FOXP3_21729870_ChIP-Seq_TREG_Human1.38403490
45* E2F1_21310950_ChIP-Seq_MCF-7_Human1.37851030
46TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.37644086
47EGR1_19374776_ChIP-ChIP_THP-1_Human1.35113902
48PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.32542459
49CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.31891809
50GABP_19822575_ChIP-Seq_HepG2_Human1.28321320
51KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.28157576
52MYCN_18555785_ChIP-Seq_MESCs_Mouse1.26538388
53NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.24785422
54POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.21254542
55* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.20294624
56POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.20113161
57HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.19933072
58* NANOG_18555785_ChIP-Seq_MESCs_Mouse1.19483230
59CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.18734610
60PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.18717152
61NCOR1_26117541_ChIP-Seq_K562_Human1.18052348
62FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.18048989
63VDR_21846776_ChIP-Seq_THP-1_Human1.17417742
64CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.17283553
65MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.16858061
66HOXB4_20404135_ChIP-ChIP_EML_Mouse1.16419252
67HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.16324682
68* SRF_21415370_ChIP-Seq_HL-1_Mouse1.14299492
69TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.14206028
70MYB_21317192_ChIP-Seq_ERMYB_Mouse1.12754767
71SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.11906847
72E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.11822344
73TP63_17297297_ChIP-ChIP_HaCaT_Human1.10373384
74* KDM5A_27292631_Chip-Seq_BREAST_Human1.10289464
75NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.09809173
76ESR1_15608294_ChIP-ChIP_MCF-7_Human1.09425313
77ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.08845574
78* CLOCK_20551151_ChIP-Seq_293T_Human1.08203846
79GATA1_22025678_ChIP-Seq_K562_Human1.07552523
80* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.07306901
81STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.06932172
82CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.05425841
83MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.04484696
84GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.04186516
85IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.03979853
86* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.02451911
87STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.01822740
88KLF4_18555785_ChIP-Seq_MESCs_Mouse1.00813699
89* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.00484014
90* MAF_26560356_Chip-Seq_TH1_Human0.99472568
91ELK3_25401928_ChIP-Seq_HUVEC_Human0.99374474
92TTF2_22483619_ChIP-Seq_HELA_Human0.99357713
93SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.95436140
94* CHD1_26751641_Chip-Seq_LNCaP_Human0.95270578
95FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.93542877
96GATA1_22383799_ChIP-Seq_G1ME_Mouse0.93376816
97BRD4_27068464_Chip-Seq_AML-cells_Mouse0.93164001
98* PADI4_21655091_ChIP-ChIP_MCF-7_Human0.92968169
99CIITA_25753668_ChIP-Seq_RAJI_Human0.91295633
100* KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.90681152
101TFEB_21752829_ChIP-Seq_HELA_Human0.90646227
102NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.90117389
103ELK1_19687146_ChIP-ChIP_HELA_Human0.89873232
104IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.89088339
105SPI1_23547873_ChIP-Seq_NB4_Human0.88737565
106SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.88695915
107VDR_24763502_ChIP-Seq_THP-1_Human0.88694648
108SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.88301312
109CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.87758686
110YY1_21170310_ChIP-Seq_MESCs_Mouse0.87697699
111* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.86254052
112* MAF_26560356_Chip-Seq_TH2_Human0.85983788
113BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.85900010
114HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.84859414
115ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.84327511
116NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.84281333
117* CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.83907311
118PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.83617869
119STAT4_19710469_ChIP-ChIP_TH1__Mouse0.83448244
120RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.83323343
121KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.82991359
122* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.82223038
123GATA2_22383799_ChIP-Seq_G1ME_Mouse0.82189833
124OCT4_18692474_ChIP-Seq_MEFs_Mouse0.81776020
125TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.81728577

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.17189066
2MP0005360_urolithiasis5.14089581
3MP0005365_abnormal_bile_salt4.01401394
4MP0003806_abnormal_nucleotide_metabolis3.99912133
5MP0005085_abnormal_gallbladder_physiolo3.85434443
6MP0002877_abnormal_melanocyte_morpholog3.10038113
7MP0008875_abnormal_xenobiotic_pharmacok3.04777807
8MP0010329_abnormal_lipoprotein_level2.53035996
9MP0009840_abnormal_foam_cell2.51971602
10MP0003191_abnormal_cellular_cholesterol2.47969564
11MP0003693_abnormal_embryo_hatching2.26136671
12MP0003252_abnormal_bile_duct2.21547125
13MP0003186_abnormal_redox_activity2.08822551
14MP0003786_premature_aging2.01222807
15MP0005332_abnormal_amino_acid1.88612942
16MP0000609_abnormal_liver_physiology1.80773875
17MP0004808_abnormal_hematopoietic_stem1.77978606
18MP0001666_abnormal_nutrient_absorption1.77714384
19MP0004957_abnormal_blastocyst_morpholog1.74387741
20MP0003705_abnormal_hypodermis_morpholog1.65999065
21MP0010234_abnormal_vibrissa_follicle1.65499690
22MP0010094_abnormal_chromosome_stability1.64908558
23MP0005319_abnormal_enzyme/_coenzyme1.62426089
24MP0002009_preneoplasia1.62176445
25MP0003111_abnormal_nucleus_morphology1.62175837
26MP0005083_abnormal_biliary_tract1.59962355
27MP0001764_abnormal_homeostasis1.57408471
28MP0001661_extended_life_span1.54227885
29MP0002166_altered_tumor_susceptibility1.51422933
30MP0010352_gastrointestinal_tract_polyps1.50872461
31MP0005058_abnormal_lysosome_morphology1.49332824
32MP0005670_abnormal_white_adipose1.48778282
33MP0008057_abnormal_DNA_replication1.48244582
34MP0004019_abnormal_vitamin_homeostasis1.44182562
35MP0003077_abnormal_cell_cycle1.41732689
36MP0002080_prenatal_lethality1.41259996
37MP0001853_heart_inflammation1.39131353
38MP0003763_abnormal_thymus_physiology1.37224097
39MP0002118_abnormal_lipid_homeostasis1.34452668
40MP0002396_abnormal_hematopoietic_system1.33035667
41MP0001697_abnormal_embryo_size1.32876105
42MP0003195_calcinosis1.31322054
43MP0005076_abnormal_cell_differentiation1.30421020
44MP0000598_abnormal_liver_morphology1.29186228
45MP0000678_abnormal_parathyroid_gland1.26778724
46MP0000358_abnormal_cell_content/1.24762624
47MP0003656_abnormal_erythrocyte_physiolo1.21594205
48MP0000703_abnormal_thymus_morphology1.19380304
49MP0002138_abnormal_hepatobiliary_system1.19248526
50MP0009643_abnormal_urine_homeostasis1.19010533
51MP0004233_abnormal_muscle_weight1.18841421
52MP0002006_tumorigenesis1.16469198
53MP0003436_decreased_susceptibility_to1.15583107
54MP0002132_abnormal_respiratory_system1.14305250
55MP0006036_abnormal_mitochondrial_physio1.11841443
56MP0002086_abnormal_extraembryonic_tissu1.07674702
57MP0005584_abnormal_enzyme/coenzyme_acti1.05729881
58MP0005501_abnormal_skin_physiology1.05069143
59MP0009697_abnormal_copulation1.04025190
60MP0000490_abnormal_crypts_of1.03971430
61MP0009763_increased_sensitivity_to1.03648917
62MP0008469_abnormal_protein_level1.03462576
63MP0001835_abnormal_antigen_presentation1.02156091
64MP0009278_abnormal_bone_marrow0.99831344
65MP0003718_maternal_effect0.99805631
66MP0001881_abnormal_mammary_gland0.99657217
67MP0004782_abnormal_surfactant_physiolog0.98159296
68MP0005397_hematopoietic_system_phenotyp0.96176153
69MP0001545_abnormal_hematopoietic_system0.96176153
70MP0009053_abnormal_anal_canal0.95728563
71MP0000685_abnormal_immune_system0.95408060
72MP0001730_embryonic_growth_arrest0.94747103
73MP0008058_abnormal_DNA_repair0.94608878
74MP0008007_abnormal_cellular_replicative0.94231544
75MP0005451_abnormal_body_composition0.92310990
76MP0005464_abnormal_platelet_physiology0.91799021
77MP0010307_abnormal_tumor_latency0.91622401
78MP0005621_abnormal_cell_physiology0.90736731
79MP0005666_abnormal_adipose_tissue0.90317977
80MP0005384_cellular_phenotype0.89302712
81MP0009785_altered_susceptibility_to0.88829002
82MP0003315_abnormal_perineum_morphology0.87471414
83MP0005647_abnormal_sex_gland0.86665438
84MP0000003_abnormal_adipose_tissue0.85855514
85MP0002796_impaired_skin_barrier0.84270334
86MP0002019_abnormal_tumor_incidence0.84016439
87MP0009379_abnormal_foot_pigmentation0.83535029
88MP0003221_abnormal_cardiomyocyte_apopto0.83101382
89MP0008995_early_reproductive_senescence0.81726385
90MP0001873_stomach_inflammation0.81698529
91MP0005266_abnormal_metabolism0.81504948
92MP0001727_abnormal_embryo_implantation0.80478186
93MP0005025_abnormal_response_to0.80438951
94MP0009333_abnormal_splenocyte_physiolog0.79866796
95MP0004147_increased_porphyrin_level0.79401298
96MP0004264_abnormal_extraembryonic_tissu0.79336283
97MP0002060_abnormal_skin_morphology0.79224727
98MP0005023_abnormal_wound_healing0.79138317
99MP0002970_abnormal_white_adipose0.78888222
100MP0005408_hypopigmentation0.78869627
101MP0008260_abnormal_autophagy0.78805465
102MP0002971_abnormal_brown_adipose0.78615935
103MP0005330_cardiomyopathy0.76758221
104MP0000350_abnormal_cell_proliferation0.76570154
105MP0000689_abnormal_spleen_morphology0.76508413
106MP0005375_adipose_tissue_phenotype0.75935266
107MP0009931_abnormal_skin_appearance0.73868220
108MP0003868_abnormal_feces_composition0.73776863
109MP0001845_abnormal_inflammatory_respons0.73319564
110MP0002085_abnormal_embryonic_tissue0.73237528
111MP0005376_homeostasis/metabolism_phenot0.73148993
112MP0009765_abnormal_xenobiotic_induced0.72428042
113MP0002254_reproductive_system_inflammat0.72383032
114MP0003566_abnormal_cell_adhesion0.72360560
115MP0009764_decreased_sensitivity_to0.72133834
116MP0010155_abnormal_intestine_physiology0.72094060
117MP0003724_increased_susceptibility_to0.71208548
118MP0000858_altered_metastatic_potential0.70283447
119MP0005636_abnormal_mineral_homeostasis0.70049622
120MP0009115_abnormal_fat_cell0.69935039
121MP0000716_abnormal_immune_system0.69590819
122MP0002084_abnormal_developmental_patter0.69518196
123MP0001216_abnormal_epidermal_layer0.69517521
124MP0001800_abnormal_humoral_immune0.69349997
125MP0002722_abnormal_immune_system0.69154401
126MP0005220_abnormal_exocrine_pancreas0.68599785
127MP0008932_abnormal_embryonic_tissue0.68306127
128MP0003011_delayed_dark_adaptation0.67697879
129MP0006054_spinal_hemorrhage0.65919076
130MP0004185_abnormal_adipocyte_glucose0.65904671
131MP0008873_increased_physiological_sensi0.65606359
132MP0005075_abnormal_melanosome_morpholog0.65023172
133MP0009642_abnormal_blood_homeostasis0.64697485
134MP0005380_embryogenesis_phenotype0.64301676
135MP0001672_abnormal_embryogenesis/_devel0.64301676
136MP0002136_abnormal_kidney_physiology0.64181582
137MP0006035_abnormal_mitochondrial_morpho0.62355627
138MP0005334_abnormal_fat_pad0.62138004
139MP0009672_abnormal_birth_weight0.62078059
140MP0002419_abnormal_innate_immunity0.61727986
141MP0002398_abnormal_bone_marrow0.61663507
142MP0002088_abnormal_embryonic_growth/wei0.61439908
143MP0002429_abnormal_blood_cell0.61034696
144MP0003984_embryonic_growth_retardation0.60872373
145MP0000313_abnormal_cell_death0.60792224

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of monocarboxylic acid metabolism (HP:0010996)5.01394729
2Hypobetalipoproteinemia (HP:0003563)4.89163801
3Intrahepatic cholestasis (HP:0001406)4.76126352
4Abnormality of aromatic amino acid family metabolism (HP:0004338)4.66816102
5Deep venous thrombosis (HP:0002625)4.43039003
6Xanthomatosis (HP:0000991)4.42578639
7Abnormality of pyrimidine metabolism (HP:0004353)4.11597645
8Hyperglycinuria (HP:0003108)4.09059220
9Hyperammonemia (HP:0001987)3.98578444
10Cholecystitis (HP:0001082)3.85495499
11Abnormal gallbladder physiology (HP:0012438)3.85495499
12Microvesicular hepatic steatosis (HP:0001414)3.73326555
13Hyperlipoproteinemia (HP:0010980)3.69926793
14Abnormality of serine family amino acid metabolism (HP:0010894)3.63863013
15Abnormality of glycine metabolism (HP:0010895)3.63863013
16Abnormality of glycolysis (HP:0004366)3.63048611
17Prolonged partial thromboplastin time (HP:0003645)3.62061446
18Hypolipoproteinemia (HP:0010981)3.61258555
19Progressive muscle weakness (HP:0003323)3.58071374
20Chromosomal breakage induced by crosslinking agents (HP:0003221)3.50793568
21Hypoglycemic coma (HP:0001325)3.50193299
22Chromsome breakage (HP:0040012)3.46471386
23Hyperglycinemia (HP:0002154)3.45020749
24Abnormality of fatty-acid metabolism (HP:0004359)3.44558214
25Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.42794756
26Abnormality of glutamine family amino acid metabolism (HP:0010902)3.42542230
27Abnormality of sulfur amino acid metabolism (HP:0004339)3.24021999
28Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.21891323
29Ragged-red muscle fibers (HP:0003200)3.21589697
30Complement deficiency (HP:0004431)3.20674400
31Increased serum pyruvate (HP:0003542)3.20457313
32Epidermoid cyst (HP:0200040)3.19401094
33Abnormality of aspartate family amino acid metabolism (HP:0010899)3.16699115
34Abnormality of methionine metabolism (HP:0010901)3.11366561
35Joint hemorrhage (HP:0005261)3.04329460
36Nausea (HP:0002018)3.03948550
37Abnormality of the common coagulation pathway (HP:0010990)3.01271293
38Hypoalphalipoproteinemia (HP:0003233)2.95051335
39Ketosis (HP:0001946)2.92942771
40Hypercholesterolemia (HP:0003124)2.85112980
41Abnormality of dicarboxylic acid metabolism (HP:0010995)2.83690265
42Dicarboxylic aciduria (HP:0003215)2.83690265
43Abnormality of nucleobase metabolism (HP:0010932)2.82703158
44Abnormality of the intrinsic pathway (HP:0010989)2.75474338
45Fat malabsorption (HP:0002630)2.75196981
46Abnormality of complement system (HP:0005339)2.69197389
47Multiple enchondromatosis (HP:0005701)2.67064403
48Hyperbilirubinemia (HP:0002904)2.66863236
49Seborrheic dermatitis (HP:0001051)2.65286768
50Abnormality of serum amino acid levels (HP:0003112)2.63491478
51Hypertensive crisis (HP:0100735)2.62606560
52Orthostatic hypotension (HP:0001278)2.61594766
53Acute myeloid leukemia (HP:0004808)2.52614146
54Generalized aminoaciduria (HP:0002909)2.43162579
55Abnormal cartilage morphology (HP:0002763)2.42304458
56Pallor (HP:0000980)2.40675660
57Truncus arteriosus (HP:0001660)2.40123488
58Trismus (HP:0000211)2.39200834
59Fatigue (HP:0012378)2.38035865
60Myocardial infarction (HP:0001658)2.37088067
61Lethargy (HP:0001254)2.36680096
62Spastic diplegia (HP:0001264)2.35985402
63Oral leukoplakia (HP:0002745)2.34044693
64Hypertriglyceridemia (HP:0002155)2.32132172
65Progressive external ophthalmoplegia (HP:0000590)2.29477721
66Hepatocellular carcinoma (HP:0001402)2.29256749
67Overlapping toe (HP:0001845)2.27174469
68Myelodysplasia (HP:0002863)2.25754031
69Ankyloglossia (HP:0010296)2.23403255
70Abnormality of iron homeostasis (HP:0011031)2.23156301
71Abnormality of purine metabolism (HP:0004352)2.18255915
72Proximal tubulopathy (HP:0000114)2.17977813
73Squamous cell carcinoma (HP:0002860)2.17342685
74Abnormality of transition element cation homeostasis (HP:0011030)2.17005330
75Delayed CNS myelination (HP:0002188)2.16872411
76Premature ovarian failure (HP:0008209)2.16557954
77Recurrent gram-negative bacterial infections (HP:0005420)2.16474588
78Abnormality of the preputium (HP:0100587)2.15016880
79Metabolic acidosis (HP:0001942)2.14407083
80Rough bone trabeculation (HP:0100670)2.13517129
81Increased mean platelet volume (HP:0011877)2.10815135
82Reticulocytopenia (HP:0001896)2.08929007
83Cholelithiasis (HP:0001081)2.08142487
84Steatorrhea (HP:0002570)2.07757300
85Abnormal platelet volume (HP:0011876)2.07471662
86Type I transferrin isoform profile (HP:0003642)2.07285701
87Septate vagina (HP:0001153)2.06773110
88Abnormal number of erythroid precursors (HP:0012131)2.06647138
89Acanthocytosis (HP:0001927)2.06377328
90Centrally nucleated skeletal muscle fibers (HP:0003687)2.05890974
91Abnormality of cells of the erythroid lineage (HP:0012130)2.05814658
92Poikilocytosis (HP:0004447)2.05143494
93Pancytopenia (HP:0001876)2.04932390
94Systemic lupus erythematosus (HP:0002725)2.04614456
95Pancreatitis (HP:0001733)2.03577470
96Gout (HP:0001997)2.02977795
97Thrombocytosis (HP:0001894)2.01856197
98Ketoacidosis (HP:0001993)2.01286090
99Cerebral edema (HP:0002181)1.98751083
100Recurrent viral infections (HP:0004429)1.96259056
101Renal cortical cysts (HP:0000803)1.94988060
102Abnormality of the tricuspid valve (HP:0001702)1.94949710
103Increased serum ferritin (HP:0003281)1.94602983
104Gingival bleeding (HP:0000225)1.94268361
105Rhabdomyolysis (HP:0003201)1.93717681
106Colitis (HP:0002583)1.93520923
107Hypergonadotropic hypogonadism (HP:0000815)1.93249266
108Secondary amenorrhea (HP:0000869)1.93210099
109Acute lymphatic leukemia (HP:0006721)1.90411753
110Hyperthyroidism (HP:0000836)1.89432718
111Aplastic anemia (HP:0001915)1.87994133
112Hypochromic microcytic anemia (HP:0004840)1.87911136
113Abnormality of proline metabolism (HP:0010907)1.87852177
114Hydroxyprolinuria (HP:0003080)1.87852177
115Cutaneous melanoma (HP:0012056)1.86882713
116Malnutrition (HP:0004395)1.85823699
117Nonimmune hydrops fetalis (HP:0001790)1.85631564
118Abnormality of reticulocytes (HP:0004312)1.85484412
119Aplasia/Hypoplasia of the sacrum (HP:0008517)1.83744756
120Opisthotonus (HP:0002179)1.83048057
121Thrombophlebitis (HP:0004418)1.81309643
122Esophageal varix (HP:0002040)1.79611202
123Agammaglobulinemia (HP:0004432)1.79502828
124Megaloblastic anemia (HP:0001889)1.78929737
125Hypoparathyroidism (HP:0000829)1.78787282
126Myoglobinuria (HP:0002913)1.78152541
127Reduced antithrombin III activity (HP:0001976)1.78134852
128Polycythemia (HP:0001901)1.77832599
129Late onset (HP:0003584)1.77609062
130Hepatosplenomegaly (HP:0001433)1.76855674
131Abnormality of oral frenula (HP:0000190)1.76812243
132Ileus (HP:0002595)1.76643692
133Vomiting (HP:0002013)1.76216774
134Increased muscle lipid content (HP:0009058)1.75853644
135Ureteral duplication (HP:0000073)1.75791382
136Deviation of the thumb (HP:0009603)1.75704163
137Abnormal gallbladder morphology (HP:0012437)1.74909652
138Esophageal neoplasm (HP:0100751)1.74413884
139Neoplasm of head and neck (HP:0012288)1.74413884
140Villous atrophy (HP:0011473)1.73636997
141Abnormality of small intestinal villus morphology (HP:0011472)1.73636997
142Glycosuria (HP:0003076)1.72959699
143Abnormality of urine glucose concentration (HP:0011016)1.72959699
144Brushfield spots (HP:0001088)1.72872830
145Increased intramyocellular lipid droplets (HP:0012240)1.72847986
146Vertebral compression fractures (HP:0002953)1.72772851
147Reticulocytosis (HP:0001923)1.72296827
148Petechiae (HP:0000967)1.72125656
149Entropion (HP:0000621)1.70825201
150Hyperacusis (HP:0010780)1.70722256
151Proximal placement of thumb (HP:0009623)1.70670524
152Increased nuchal translucency (HP:0010880)1.70608949
153Macrocytic anemia (HP:0001972)1.70005178
154Progressive hearing impairment (HP:0001730)1.69910880
155Birth length less than 3rd percentile (HP:0003561)1.69483581
156Increased serum lactate (HP:0002151)1.69052586
157Elevated hepatic transaminases (HP:0002910)1.68830420
158Conjugated hyperbilirubinemia (HP:0002908)1.68684144
159Hepatic necrosis (HP:0002605)1.68171546
160Abnormality of the anterior horn cell (HP:0006802)1.67421975
161Degeneration of anterior horn cells (HP:0002398)1.67421975
162Selective tooth agenesis (HP:0001592)1.66518900
163Menorrhagia (HP:0000132)1.66088033
164Impaired proprioception (HP:0010831)1.65867073
165Abnormal platelet function (HP:0011869)1.65751528
166Impaired platelet aggregation (HP:0003540)1.65751528
167Skin nodule (HP:0200036)1.65321804
168Abnormality of the umbilical cord (HP:0010881)1.64094015
169Exercise intolerance (HP:0003546)1.61501753
170Abnormality of the gallbladder (HP:0005264)1.61194611
171Sparse lateral eyebrow (HP:0005338)1.60934886
172Spastic paraparesis (HP:0002313)1.60787427
173Insomnia (HP:0100785)1.60072291
174Abnormal protein glycosylation (HP:0012346)1.59265297
175Abnormal glycosylation (HP:0012345)1.59265297
176Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.59265297
177Abnormal protein N-linked glycosylation (HP:0012347)1.59265297
178Deep philtrum (HP:0002002)1.59108442
179Abnormal trabecular bone morphology (HP:0100671)1.59089981
180IgM deficiency (HP:0002850)1.58587147
181Achilles tendon contracture (HP:0001771)1.58582637
182Cellulitis (HP:0100658)1.58511492

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK3.54919758
2EIF2AK12.73222996
3WEE12.58931487
4SMG12.55071070
5BUB12.48262616
6VRK22.35513820
7ERN12.28974389
8CDC72.24949701
9PKN22.10996971
10NME21.90287462
11TRIB31.86856737
12FLT31.84590527
13PRPF4B1.71804611
14NEK21.68043398
15NEK11.67653161
16PDK21.65638640
17ICK1.60804225
18TAOK31.60302349
19EEF2K1.59502846
20TTK1.58467917
21MAP2K31.57561372
22SIK11.56698941
23MAP3K101.55928332
24PIM21.51769771
25MAP4K11.49946382
26RPS6KB21.49027262
27PLK41.46859673
28CDK41.43997684
29STK101.42314987
30TESK21.42085676
31MST1R1.40365816
32FGFR41.37888086
33MAP3K81.34964893
34KDR1.34468927
35RIPK41.31992608
36TYK21.31509336
37CDK71.29965311
38RPS6KA41.29177877
39CLK11.29085338
40ACVR1B1.27491466
41BRSK21.26766602
42EPHA21.26415453
43MAP3K111.25948192
44PIM11.18975519
45NME11.18033857
46EIF2AK31.17805183
47LRRK21.14615748
48IRAK31.14026673
49TBK11.13328977
50AURKB1.13310572
51CDK81.13071980
52CDK61.10866764
53SRPK11.10503321
54IKBKB1.10095079
55PASK1.09468375
56PLK11.07392558
57ATR1.07030339
58STK41.04336706
59NEK91.02720160
60GRK61.01004571
61MAPKAPK31.00206584
62MAPK110.99635061
63IRAK40.97818389
64KSR20.97579525
65STK160.96966016
66CCNB10.96741282
67MAP3K130.95369371
68SCYL20.95198747
69TGFBR10.95187254
70PAK40.94839186
71MAP3K30.94009647
72MAP3K140.92957755
73ABL20.91100350
74RAF10.88828533
75TESK10.85470198
76BLK0.84375154
77PTK60.83492632
78JAK30.83340007
79BTK0.81801048
80PBK0.81111904
81BRSK10.79278006
82ALK0.79155776
83EIF2AK20.78080067
84MKNK10.77111666
85TSSK60.76382160
86DYRK30.74493784
87CDK120.72830728
88BRD40.72526509
89CSF1R0.71869116
90BMPR20.68067233
91ARAF0.65581391
92TLK10.65453238
93CDK20.64740760
94AURKA0.64575276
95ZAK0.63183051
96CHUK0.63045647
97TEC0.62004561
98CHEK10.61619066
99ZAP700.61589838
100ERBB40.60979362
101BRAF0.60455421
102KIT0.58970165
103VRK10.58282660
104IKBKE0.56624798
105CSNK2A10.56377144
106CHEK20.56267259
107PIK3CG0.55789514
108CDK10.55774974
109MST40.55758103
110STK30.53982931
111DAPK10.52004816
112MAPKAPK50.51199002
113PLK30.51191392
114JAK20.50725105
115CSNK2A20.50681345
116ILK0.50601674
117MTOR0.48353244
118TAOK20.46602733
119RPS6KA50.44215850
120CDK90.43118129
121MAP2K20.42930414
122STK38L0.42791727
123PAK10.41263131
124MAPK40.41178953
125ATM0.40540704
126MAP3K20.39564657
127PDK30.39337309
128PDK40.39337309
129DYRK1B0.38239225
130AKT20.37387757
131TRPM70.35711935

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001202.80744043
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.65292405
3Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.35610078
4One carbon pool by folate_Homo sapiens_hsa006702.24540891
5DNA replication_Homo sapiens_hsa030302.23185013
6Nitrogen metabolism_Homo sapiens_hsa009102.19732391
7Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.19380371
8Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.15424280
9Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.09204787
10Fatty acid degradation_Homo sapiens_hsa000712.06587265
11Arginine biosynthesis_Homo sapiens_hsa002201.99603438
12Pentose and glucuronate interconversions_Homo sapiens_hsa000401.98971689
13Tryptophan metabolism_Homo sapiens_hsa003801.95153349
14Drug metabolism - other enzymes_Homo sapiens_hsa009831.90569676
15Selenocompound metabolism_Homo sapiens_hsa004501.80009116
162-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.77088622
17Propanoate metabolism_Homo sapiens_hsa006401.75197771
18Mismatch repair_Homo sapiens_hsa034301.71973415
19Complement and coagulation cascades_Homo sapiens_hsa046101.66146867
20Caffeine metabolism_Homo sapiens_hsa002321.66027191
21Peroxisome_Homo sapiens_hsa041461.65260542
22PPAR signaling pathway_Homo sapiens_hsa033201.62951619
23Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.59515907
24Folate biosynthesis_Homo sapiens_hsa007901.57810945
25Biosynthesis of amino acids_Homo sapiens_hsa012301.55233764
26Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.54292361
27Carbon metabolism_Homo sapiens_hsa012001.52693757
28Cysteine and methionine metabolism_Homo sapiens_hsa002701.47973296
29Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.47084588
30Cyanoamino acid metabolism_Homo sapiens_hsa004601.46301812
31beta-Alanine metabolism_Homo sapiens_hsa004101.44780163
32Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.44112907
33Fatty acid metabolism_Homo sapiens_hsa012121.40601272
34Ribosome_Homo sapiens_hsa030101.40582183
35Chemical carcinogenesis_Homo sapiens_hsa052041.40461262
36Pentose phosphate pathway_Homo sapiens_hsa000301.36050739
37Histidine metabolism_Homo sapiens_hsa003401.34791293
38Proteasome_Homo sapiens_hsa030501.33274400
39Pyruvate metabolism_Homo sapiens_hsa006201.32568697
40Sulfur relay system_Homo sapiens_hsa041221.31777269
41Base excision repair_Homo sapiens_hsa034101.31713411
42Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.31048493
43Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.30812606
44Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.25411970
45Staphylococcus aureus infection_Homo sapiens_hsa051501.25297478
46Phenylalanine metabolism_Homo sapiens_hsa003601.25223771
47mRNA surveillance pathway_Homo sapiens_hsa030151.21977753
48Fat digestion and absorption_Homo sapiens_hsa049751.20752360
49Steroid hormone biosynthesis_Homo sapiens_hsa001401.19601860
50Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.18018466
51Other glycan degradation_Homo sapiens_hsa005111.17689520
52Butanoate metabolism_Homo sapiens_hsa006501.16099405
53Retinol metabolism_Homo sapiens_hsa008301.15215052
54Glutathione metabolism_Homo sapiens_hsa004801.12195933
55Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.12112387
56Pyrimidine metabolism_Homo sapiens_hsa002401.10321590
57Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.04653594
58Starch and sucrose metabolism_Homo sapiens_hsa005001.03460650
59Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.02160380
60Tyrosine metabolism_Homo sapiens_hsa003501.02131614
61N-Glycan biosynthesis_Homo sapiens_hsa005101.00698611
62Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.00424346
63Homologous recombination_Homo sapiens_hsa034400.98927470
64Chronic myeloid leukemia_Homo sapiens_hsa052200.97099577
65Acute myeloid leukemia_Homo sapiens_hsa052210.96207291
66Nucleotide excision repair_Homo sapiens_hsa034200.93145752
67Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.92178133
68RNA transport_Homo sapiens_hsa030130.90706728
69Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.89536753
70Thyroid cancer_Homo sapiens_hsa052160.89035759
71Spliceosome_Homo sapiens_hsa030400.87735443
72Central carbon metabolism in cancer_Homo sapiens_hsa052300.86761498
73Arginine and proline metabolism_Homo sapiens_hsa003300.86392820
74Pancreatic cancer_Homo sapiens_hsa052120.83569119
75Epstein-Barr virus infection_Homo sapiens_hsa051690.81911719
76Sulfur metabolism_Homo sapiens_hsa009200.80630132
77Fructose and mannose metabolism_Homo sapiens_hsa000510.78479221
78Vitamin digestion and absorption_Homo sapiens_hsa049770.77964108
79Non-small cell lung cancer_Homo sapiens_hsa052230.77884260
80Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.75483999
81RNA polymerase_Homo sapiens_hsa030200.74190616
82Vitamin B6 metabolism_Homo sapiens_hsa007500.74136001
83Galactose metabolism_Homo sapiens_hsa000520.72414938
84Lysine degradation_Homo sapiens_hsa003100.71557118
85Bladder cancer_Homo sapiens_hsa052190.71230624
86ABC transporters_Homo sapiens_hsa020100.69894695
87Glycerolipid metabolism_Homo sapiens_hsa005610.67965428
88Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.67346830
89Fatty acid elongation_Homo sapiens_hsa000620.64971698
90Bile secretion_Homo sapiens_hsa049760.63750862
91Cell cycle_Homo sapiens_hsa041100.63733641
92Steroid biosynthesis_Homo sapiens_hsa001000.56461263
93p53 signaling pathway_Homo sapiens_hsa041150.53515433
94Parkinsons disease_Homo sapiens_hsa050120.53481273
95* Metabolic pathways_Homo sapiens_hsa011000.53347749
96B cell receptor signaling pathway_Homo sapiens_hsa046620.52096464
97Shigellosis_Homo sapiens_hsa051310.50909432
98Legionellosis_Homo sapiens_hsa051340.50294550
99HTLV-I infection_Homo sapiens_hsa051660.50171147
100Small cell lung cancer_Homo sapiens_hsa052220.48132201
101Non-homologous end-joining_Homo sapiens_hsa034500.47999733
102Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.47542118
103Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.46851849
104Hepatitis B_Homo sapiens_hsa051610.46066154
105Fatty acid biosynthesis_Homo sapiens_hsa000610.45636420
106Maturity onset diabetes of the young_Homo sapiens_hsa049500.43320364
107Huntingtons disease_Homo sapiens_hsa050160.43239358
108Protein export_Homo sapiens_hsa030600.42973224
109Apoptosis_Homo sapiens_hsa042100.42613505
110Systemic lupus erythematosus_Homo sapiens_hsa053220.42143708
111RNA degradation_Homo sapiens_hsa030180.41278669
112Primary immunodeficiency_Homo sapiens_hsa053400.41020518
113Fanconi anemia pathway_Homo sapiens_hsa034600.37970613
114Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.35430129
115Influenza A_Homo sapiens_hsa051640.33189205
116Measles_Homo sapiens_hsa051620.32683251
117Oxidative phosphorylation_Homo sapiens_hsa001900.31802194
118Transcriptional misregulation in cancer_Homo sapiens_hsa052020.31212660
119Herpes simplex infection_Homo sapiens_hsa051680.29934135
120Basal transcription factors_Homo sapiens_hsa030220.28800375
121Oocyte meiosis_Homo sapiens_hsa041140.28434583
122HIF-1 signaling pathway_Homo sapiens_hsa040660.27611295
123Antigen processing and presentation_Homo sapiens_hsa046120.27295180
124Linoleic acid metabolism_Homo sapiens_hsa005910.27107326
125alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.26268566
126Renin-angiotensin system_Homo sapiens_hsa046140.24133744
127* Purine metabolism_Homo sapiens_hsa002300.22576604
128Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.22476926
129NF-kappa B signaling pathway_Homo sapiens_hsa040640.21448275
130Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.20590146
131Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.20309055
132Viral carcinogenesis_Homo sapiens_hsa052030.18943825
133Arachidonic acid metabolism_Homo sapiens_hsa005900.18119092

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