AIPL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Leber congenital amaurosis (LCA) is the most severe inherited retinopathy with the earliest age of onset and accounts for at least 5% of all inherited retinal diseases. Affected individuals are diagnosed at birth or in the first few months of life with nystagmus, severely impaired vision or blindness and an abnormal or flat electroretinogram. The photoreceptor/pineal-expressed gene, AIPL1, encoding aryl-hydrocarbon interacting protein-like 1, is located within the LCA4 candidate region. The encoded protein contains three tetratricopeptide motifs, consistent with chaperone or nuclear transport activity. Mutations in this gene may cause approximately 20% of recessive LCA. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* detection of visible light (GO:0009584)9.92752977
2retinal rod cell development (GO:0046548)9.77471297
3protein-chromophore linkage (GO:0018298)9.22538979
4regulation of guanylate cyclase activity (GO:0031282)9.06046425
5* visual perception (GO:0007601)8.84395426
6* sensory perception of light stimulus (GO:0050953)8.74643153
7cellular response to light stimulus (GO:0071482)7.75485961
8photoreceptor cell differentiation (GO:0046530)7.46529304
9eye photoreceptor cell differentiation (GO:0001754)7.46529304
10* detection of external stimulus (GO:0009581)7.07790553
11retina development in camera-type eye (GO:0060041)6.98011954
12* detection of abiotic stimulus (GO:0009582)6.94337813
13positive regulation of cGMP biosynthetic process (GO:0030828)5.85895044
14regulation of cGMP biosynthetic process (GO:0030826)5.48528336
15regulation of inhibitory postsynaptic membrane potential (GO:0060080)5.38817050
16detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)5.23989383
17positive regulation of cGMP metabolic process (GO:0030825)5.17278040
18behavioral response to nicotine (GO:0035095)5.08463653
19cellular response to radiation (GO:0071478)5.06496959
20cell morphogenesis involved in neuron differentiation (GO:0048667)5.03738706
21positive regulation of synaptic transmission, dopaminergic (GO:0032226)4.98477338
22nonmotile primary cilium assembly (GO:0035058)4.93883300
23* regulation of cGMP metabolic process (GO:0030823)4.87078853
24receptor guanylyl cyclase signaling pathway (GO:0007168)4.75118845
25adaptation of signaling pathway (GO:0023058)4.56604332
26regulation of G-protein coupled receptor protein signaling pathway (GO:0008277)4.53158308
27fucose catabolic process (GO:0019317)4.48946397
28L-fucose metabolic process (GO:0042354)4.48946397
29L-fucose catabolic process (GO:0042355)4.48946397
30regulation of voltage-gated calcium channel activity (GO:1901385)4.30249737
31* sensory perception (GO:0007600)4.16835425
32cornea development in camera-type eye (GO:0061303)4.04187216
33regulation of clathrin-mediated endocytosis (GO:2000369)4.02522803
34* response to light stimulus (GO:0009416)3.89132639
35neuron development (GO:0048666)3.87194069
36retina layer formation (GO:0010842)3.79496770
37cellular ketone body metabolic process (GO:0046950)3.75673518
38estrogen biosynthetic process (GO:0006703)3.70391077
39protein complex biogenesis (GO:0070271)3.65742659
40short-term memory (GO:0007614)3.63639243
41signal peptide processing (GO:0006465)3.61531124
42DNA deamination (GO:0045006)3.59016385
43L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.58607086
44regulation of penile erection (GO:0060405)3.57678919
45behavioral response to ethanol (GO:0048149)3.57140984
46regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)3.55255099
47regulation of dopamine uptake involved in synaptic transmission (GO:0051584)3.55255099
48kynurenine metabolic process (GO:0070189)3.47926077
49protein-cofactor linkage (GO:0018065)3.46271149
50regulation of glucokinase activity (GO:0033131)3.45694689
51regulation of hexokinase activity (GO:1903299)3.45694689
52protein localization to synapse (GO:0035418)3.44547231
53ketone body metabolic process (GO:1902224)3.43875143
54negative regulation of receptor-mediated endocytosis (GO:0048261)3.41713711
55chemosensory behavior (GO:0007635)3.40248416
56positive regulation of sodium ion transmembrane transporter activity (GO:2000651)3.38132743
57mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.34696709
58mitochondrial respiratory chain complex I assembly (GO:0032981)3.34696709
59NADH dehydrogenase complex assembly (GO:0010257)3.34696709
60mitochondrial respiratory chain complex assembly (GO:0033108)3.33273198
61response to histamine (GO:0034776)3.29216120
62positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.28742089
63tryptophan catabolic process (GO:0006569)3.26544205
64indole-containing compound catabolic process (GO:0042436)3.26544205
65indolalkylamine catabolic process (GO:0046218)3.26544205
66positive regulation of neurotransmitter transport (GO:0051590)3.24021425
67platelet dense granule organization (GO:0060155)3.20386074
68energy coupled proton transport, down electrochemical gradient (GO:0015985)3.19949535
69ATP synthesis coupled proton transport (GO:0015986)3.19949535
70positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.19423263
71RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.17781728
72tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.17781728
73regulation of short-term neuronal synaptic plasticity (GO:0048172)3.13465433
74amino acid salvage (GO:0043102)3.12619352
75L-methionine salvage (GO:0071267)3.12619352
76L-methionine biosynthetic process (GO:0071265)3.12619352
77indolalkylamine metabolic process (GO:0006586)3.12406158
78positive regulation of sodium ion transmembrane transport (GO:1902307)3.11478087
79membrane hyperpolarization (GO:0060081)3.10714471
80detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.10681595
81epithelial cilium movement (GO:0003351)3.09107050
82multicellular organism reproduction (GO:0032504)3.07931338
83respiratory chain complex IV assembly (GO:0008535)3.06943503
84gamma-aminobutyric acid transport (GO:0015812)3.06665127
85peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.06499211
86epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.04416567
87cytochrome complex assembly (GO:0017004)3.02385045
88detection of chemical stimulus involved in sensory perception of taste (GO:0050912)3.00828781
89G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.98996701
90regulation of cilium movement (GO:0003352)2.96756297
91cilium morphogenesis (GO:0060271)2.96478433
92water-soluble vitamin biosynthetic process (GO:0042364)2.93712986
93mannosylation (GO:0097502)2.93448868
94retinoid metabolic process (GO:0001523)2.89404438
95mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.88989256
96CDP-diacylglycerol biosynthetic process (GO:0016024)2.88643231
97pyrimidine nucleobase catabolic process (GO:0006208)2.86588337
98protein polyglutamylation (GO:0018095)2.86296882
99amine catabolic process (GO:0009310)2.85301779
100cellular biogenic amine catabolic process (GO:0042402)2.85301779
101detection of chemical stimulus involved in sensory perception (GO:0050907)2.83935008
102positive regulation of G-protein coupled receptor protein signaling pathway (GO:0045745)2.82700875
103preassembly of GPI anchor in ER membrane (GO:0016254)2.82578091
104icosanoid secretion (GO:0032309)2.82154869
105arachidonic acid secretion (GO:0050482)2.82154869
106protein heterotetramerization (GO:0051290)2.80221862
107neuronal action potential propagation (GO:0019227)2.79764639
108vitamin A metabolic process (GO:0006776)2.79598879
109negative regulation of cation channel activity (GO:2001258)2.79400396
110negative regulation of calcium ion transmembrane transport (GO:1903170)2.71886601
111negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.71886601
112tryptophan metabolic process (GO:0006568)2.71452693
113protein localization to cilium (GO:0061512)2.71436761
114* response to radiation (GO:0009314)2.70384012
115positive regulation of epidermal growth factor receptor signaling pathway (GO:0045742)2.69922818
116cellular response to electrical stimulus (GO:0071257)2.67500827
117diterpenoid metabolic process (GO:0016101)2.67316633
118sperm motility (GO:0030317)2.66396708
119behavioral response to cocaine (GO:0048148)2.65121434
120piRNA metabolic process (GO:0034587)2.63315320
121negative regulation of telomere maintenance (GO:0032205)2.63303178
122CDP-diacylglycerol metabolic process (GO:0046341)2.62948121
123dopamine receptor signaling pathway (GO:0007212)2.62401147
124synaptic vesicle maturation (GO:0016188)2.61779553
125nephron epithelium morphogenesis (GO:0072088)2.60292464
126nephron tubule morphogenesis (GO:0072078)2.60292464
127male meiosis I (GO:0007141)2.58959012
128nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.58775809
129nucleobase catabolic process (GO:0046113)2.58410334
130mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.58090449
131synaptic transmission, dopaminergic (GO:0001963)2.57607205
132retinol metabolic process (GO:0042572)2.56685305
133post-embryonic morphogenesis (GO:0009886)2.56642567
134reciprocal DNA recombination (GO:0035825)2.55854878
135reciprocal meiotic recombination (GO:0007131)2.55854878
136cellular response to abiotic stimulus (GO:0071214)2.55488474
137exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.55283586
138negative regulation of transcription regulatory region DNA binding (GO:2000678)2.55242071
139protein neddylation (GO:0045116)2.54939431
140hindbrain development (GO:0030902)2.54843647
141lipoprotein transport (GO:0042953)2.54367959
142protein K6-linked ubiquitination (GO:0085020)2.53724180
143primary amino compound metabolic process (GO:1901160)2.52554294
144lipid translocation (GO:0034204)2.52482266
145phospholipid translocation (GO:0045332)2.52482266
146reflex (GO:0060004)2.52222339
147positive regulation of ERBB signaling pathway (GO:1901186)2.51014173
148indole-containing compound metabolic process (GO:0042430)2.50492320
149branched-chain amino acid catabolic process (GO:0009083)2.50354537
150magnesium ion transport (GO:0015693)2.50127550
151somite development (GO:0061053)2.50012235
152retinal ganglion cell axon guidance (GO:0031290)2.49886000
153neuronal action potential (GO:0019228)2.49457475
154axoneme assembly (GO:0035082)2.48710712
155kidney morphogenesis (GO:0060993)2.47525175
156cilium organization (GO:0044782)2.46809005
157synaptic vesicle docking involved in exocytosis (GO:0016081)2.46670032
158phosphatidylinositol acyl-chain remodeling (GO:0036149)2.45207368
159sulfation (GO:0051923)2.45056134
160inositol phosphate catabolic process (GO:0071545)2.44024456
161terpenoid metabolic process (GO:0006721)2.43262947
162spinal cord motor neuron differentiation (GO:0021522)2.43215933
163regulation of neurotransmitter uptake (GO:0051580)2.40996403
164positive regulation of cyclase activity (GO:0031281)2.40775931
165righting reflex (GO:0060013)2.37346307
166sensory perception of smell (GO:0007608)2.33869672
167positive regulation of membrane potential (GO:0045838)2.33390295
168response to pheromone (GO:0019236)2.32345342
169fatty acid derivative transport (GO:1901571)2.23812257
170icosanoid transport (GO:0071715)2.23812257
171regulation of rhodopsin mediated signaling pathway (GO:0022400)18.8963990
172rhodopsin mediated signaling pathway (GO:0016056)18.5031665
173retinal cone cell development (GO:0046549)15.6427079
174photoreceptor cell development (GO:0042461)13.1040110
175eye photoreceptor cell development (GO:0042462)12.4601506
176photoreceptor cell maintenance (GO:0045494)11.8928324
177detection of light stimulus involved in visual perception (GO:0050908)11.1909194
178detection of light stimulus involved in sensory perception (GO:0050962)11.1909194
179* phototransduction (GO:0007602)10.6816145
180GMP metabolic process (GO:0046037)10.5964100
181* phototransduction, visible light (GO:0007603)10.3701948
182* detection of light stimulus (GO:0009583)10.1451959
183positive regulation of guanylate cyclase activity (GO:0031284)10.0532163

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.24045126
2ZNF274_21170338_ChIP-Seq_K562_Hela4.08239391
3VDR_22108803_ChIP-Seq_LS180_Human3.97749742
4* CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse3.93935728
5GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.65188328
6EZH2_22144423_ChIP-Seq_EOC_Human2.88531675
7GBX2_23144817_ChIP-Seq_PC3_Human2.71785219
8CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.57557748
9GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.54323418
10ZFP57_27257070_Chip-Seq_ESCs_Mouse2.36810649
11E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.28303778
12DROSHA_22980978_ChIP-Seq_HELA_Human2.22287995
13CTBP2_25329375_ChIP-Seq_LNCAP_Human2.21581911
14DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.17440585
15HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.15731016
16FLI1_27457419_Chip-Seq_LIVER_Mouse2.07938704
17CTBP1_25329375_ChIP-Seq_LNCAP_Human2.07097196
18EWS_26573619_Chip-Seq_HEK293_Human2.05617460
19TAF15_26573619_Chip-Seq_HEK293_Human1.97852377
20SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.96401335
21GABP_17652178_ChIP-ChIP_JURKAT_Human1.93681518
22IKZF1_21737484_ChIP-ChIP_HCT116_Human1.91980137
23FUS_26573619_Chip-Seq_HEK293_Human1.87080147
24MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.85793770
25BMI1_23680149_ChIP-Seq_NPCS_Mouse1.84065722
26SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.81366955
27EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.79664763
28SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.78211553
29SMAD3_21741376_ChIP-Seq_HESCs_Human1.77520485
30EZH2_27294783_Chip-Seq_ESCs_Mouse1.76170318
31* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.75916292
32ER_23166858_ChIP-Seq_MCF-7_Human1.73850486
33MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.65872300
34* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.64932626
35POU3F2_20337985_ChIP-ChIP_501MEL_Human1.64485144
36EST1_17652178_ChIP-ChIP_JURKAT_Human1.64191836
37AR_21572438_ChIP-Seq_LNCaP_Human1.61461544
38KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.61293243
39TCF4_18268006_ChIP-ChIP_LS174T_Human1.60853098
40P53_22127205_ChIP-Seq_FIBROBLAST_Human1.58638804
41NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.58415331
42* CBX2_27304074_Chip-Seq_ESCs_Mouse1.56284839
43IRF1_19129219_ChIP-ChIP_H3396_Human1.56081831
44HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.53949853
45MYC_18940864_ChIP-ChIP_HL60_Human1.53731078
46* REST_21632747_ChIP-Seq_MESCs_Mouse1.53359684
47TP53_22573176_ChIP-Seq_HFKS_Human1.53295445
48MTF2_20144788_ChIP-Seq_MESCs_Mouse1.52424429
49* REST_18959480_ChIP-ChIP_MESCs_Mouse1.51663772
50AR_19668381_ChIP-Seq_PC3_Human1.51592889
51KDM2B_26808549_Chip-Seq_K562_Human1.51072372
52CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.50712230
53CBP_20019798_ChIP-Seq_JUKART_Human1.48168783
54IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.48168783
55UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.46822908
56SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.46662499
57PCGF2_27294783_Chip-Seq_ESCs_Mouse1.46170925
58SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.45852455
59ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.44876786
60RNF2_27304074_Chip-Seq_NSC_Mouse1.44758470
61NANOG_19829295_ChIP-Seq_ESCs_Human1.43153268
62SOX2_19829295_ChIP-Seq_ESCs_Human1.43153268
63FOXA1_27270436_Chip-Seq_PROSTATE_Human1.41911460
64FOXA1_25329375_ChIP-Seq_VCAP_Human1.41911460
65PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.41346677
66TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.41007314
67GATA3_21878914_ChIP-Seq_MCF-7_Human1.40908078
68IGF1R_20145208_ChIP-Seq_DFB_Human1.40826255
69JARID2_20075857_ChIP-Seq_MESCs_Mouse1.40594453
70EZH2_18974828_ChIP-Seq_MESCs_Mouse1.40535828
71RNF2_18974828_ChIP-Seq_MESCs_Mouse1.40535828
72TBL1_22424771_ChIP-Seq_293T_Human1.38191905
73RING1B_27294783_Chip-Seq_NPCs_Mouse1.37809462
74* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.37743017
75AR_25329375_ChIP-Seq_VCAP_Human1.37462746
76GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.36382746
77RNF2_27304074_Chip-Seq_ESCs_Mouse1.35992068
78RARB_27405468_Chip-Seq_BRAIN_Mouse1.35196956
79SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.34263049
80NOTCH1_21737748_ChIP-Seq_TLL_Human1.33681052
81TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33640377
82POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.33640377
83SMAD4_21799915_ChIP-Seq_A2780_Human1.32401463
84CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.32109176
85SALL1_21062744_ChIP-ChIP_HESCs_Human1.31643953
86NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse1.31544274
87SMC4_20622854_ChIP-Seq_HELA_Human1.30718205
88EZH2_27304074_Chip-Seq_ESCs_Mouse1.30573763
89FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.30543204
90TCF4_22108803_ChIP-Seq_LS180_Human1.30530127
91GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.29730056
92NR3C1_21868756_ChIP-Seq_MCF10A_Human1.28418039
93CTCF_27219007_Chip-Seq_Bcells_Human1.27346417
94SMAD3_21741376_ChIP-Seq_EPCs_Human1.25884885
95ELK4_26923725_Chip-Seq_MESODERM_Mouse1.25565892
96FOXA1_21572438_ChIP-Seq_LNCaP_Human1.23920959
97EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.23312835
98PIAS1_25552417_ChIP-Seq_VCAP_Human1.23001021
99* RUNX2_22187159_ChIP-Seq_PCA_Human1.18783523
100TOP2B_26459242_ChIP-Seq_MCF-7_Human1.18531831
101PRDM14_20953172_ChIP-Seq_ESCs_Human1.18230218
102ETV2_25802403_ChIP-Seq_MESCs_Mouse1.16254490
103STAT3_23295773_ChIP-Seq_U87_Human1.15945132
104EZH2_27294783_Chip-Seq_NPCs_Mouse1.15442551
105AR_20517297_ChIP-Seq_VCAP_Human1.14248546
106TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.12672293
107EED_16625203_ChIP-ChIP_MESCs_Mouse1.12384019
108AUTS2_25519132_ChIP-Seq_293T-REX_Human1.11472027
109KLF5_20875108_ChIP-Seq_MESCs_Mouse1.11323681
110SUZ12_27294783_Chip-Seq_NPCs_Mouse1.11037058
111SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.10478368
112SMAD4_21741376_ChIP-Seq_EPCs_Human1.10367167
113PCGF2_27294783_Chip-Seq_NPCs_Mouse1.10173124
114BCAT_22108803_ChIP-Seq_LS180_Human1.10111315
115P300_19829295_ChIP-Seq_ESCs_Human1.09963037
116NFE2_27457419_Chip-Seq_LIVER_Mouse1.09543008
117ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.09518386
118NCOR_22424771_ChIP-Seq_293T_Human1.09242309
119JARID2_20064375_ChIP-Seq_MESCs_Mouse1.08023867
120EGR1_19032775_ChIP-ChIP_M12_Human1.07467305
121* NANOG_20526341_ChIP-Seq_ESCs_Human1.07430307
122EP300_21415370_ChIP-Seq_HL-1_Mouse1.07116551
123POU5F1_16153702_ChIP-ChIP_HESCs_Human1.07037512
124WDR5_24793694_ChIP-Seq_LNCAP_Human1.07035081
125EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.06408491
126HOXB7_26014856_ChIP-Seq_BT474_Human1.06156842
127TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.05541893
128FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.05292657
129MYC_19829295_ChIP-Seq_ESCs_Human1.05282962
130* TAF2_19829295_ChIP-Seq_ESCs_Human1.04096266
131SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.03470271
132ERA_21632823_ChIP-Seq_H3396_Human1.03416725
133CBP_21632823_ChIP-Seq_H3396_Human1.01546382
134SMAD4_21741376_ChIP-Seq_HESCs_Human1.01385054
135CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.00947913
136VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.00106582
137P68_20966046_ChIP-Seq_HELA_Human0.99710758
138FOXH1_21741376_ChIP-Seq_EPCs_Human0.99104763
139GATA1_19941827_ChIP-Seq_MEL_Mouse0.98427562
140RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.97333036
141* CTCF_20526341_ChIP-Seq_ESCs_Human0.97181086
142KDM2B_26808549_Chip-Seq_JURKAT_Human0.96702766
143P53_22387025_ChIP-Seq_ESCs_Mouse0.96691624
144CRX_20693478_ChIP-Seq_RETINA_Mouse0.96400419
145SA1_27219007_Chip-Seq_Bcells_Human0.95759722
146OCT1_27270436_Chip-Seq_PROSTATE_Human0.95641027
147EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.95268084
148SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95221025
149VDR_23849224_ChIP-Seq_CD4+_Human0.95062674
150ERG_20517297_ChIP-Seq_VCAP_Human0.94631445
151MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.93994286
152YAP1_20516196_ChIP-Seq_MESCs_Mouse0.93992950
153CREB1_26743006_Chip-Seq_LNCaP_Human0.93576068
154MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.92548751
155TCF4_23295773_ChIP-Seq_U87_Human0.91953462
156DPY_21335234_ChIP-Seq_ESCs_Mouse0.91920956
157CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.91367496
158NANOG_18555785_Chip-Seq_ESCs_Mouse0.90907496
159TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.90564210
160OCT4_19829295_ChIP-Seq_ESCs_Human0.90530821
161AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.90512338
162ERG_21242973_ChIP-ChIP_JURKAT_Human0.89932165
163SMAD4_21741376_ChIP-Seq_ESCs_Human0.88423597
164ISL1_27105846_Chip-Seq_CPCs_Mouse0.86283255
165RUNX_20019798_ChIP-Seq_JUKART_Human0.85974407
166BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.85810474
167LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.85618635
168DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.85449925
169* RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.83955616
170FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.82028133
171CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.81718385
172RING1B_27294783_Chip-Seq_ESCs_Mouse0.81340221
173SMAD3_21741376_ChIP-Seq_ESCs_Human0.81234523
174* GF1_26923725_Chip-Seq_HPCs_Mouse0.80989175
175GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.80306863

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0005551_abnormal_eye_electrophysiolog9.55483293
2MP0005253_abnormal_eye_physiology6.91241155
3MP0006072_abnormal_retinal_apoptosis6.64221931
4MP0003950_abnormal_plasma_membrane3.94067166
5* MP0005195_abnormal_posterior_eye3.81842586
6MP0001324_abnormal_eye_pigmentation3.55613281
7MP0005391_vision/eye_phenotype3.35070965
8MP0002638_abnormal_pupillary_reflex3.18780314
9MP0008877_abnormal_DNA_methylation3.06518926
10MP0002090_abnormal_vision2.86982585
11MP0005423_abnormal_somatic_nervous2.84673494
12MP0001986_abnormal_taste_sensitivity2.66195174
13MP0003787_abnormal_imprinting2.55787078
14* MP0002229_neurodegeneration2.41808213
15MP0005645_abnormal_hypothalamus_physiol2.32197293
16MP0001764_abnormal_homeostasis2.16977238
17MP0002938_white_spotting2.14357299
18MP0003195_calcinosis2.03625897
19MP0003011_delayed_dark_adaptation11.1801637
20MP0008875_abnormal_xenobiotic_pharmacok1.89429973
21* MP0002752_abnormal_somatic_nervous1.87912668
22MP0003283_abnormal_digestive_organ1.67533978
23MP0004133_heterotaxia1.60365533
24MP0008872_abnormal_physiological_respon1.56466818
25MP0002876_abnormal_thyroid_physiology1.53420768
26MP0002736_abnormal_nociception_after1.51903229
27MP0002837_dystrophic_cardiac_calcinosis1.47923167
28MP0003121_genomic_imprinting1.47792445
29MP0005410_abnormal_fertilization1.46216462
30MP0002653_abnormal_ependyma_morphology1.45377935
31MP0002160_abnormal_reproductive_system1.43090391
32MP0000372_irregular_coat_pigmentation1.42856173
33MP0006276_abnormal_autonomic_nervous1.40927868
34MP0001529_abnormal_vocalization1.40716265
35MP0004147_increased_porphyrin_level1.36465549
36MP0002234_abnormal_pharynx_morphology1.34690484
37* MP0002882_abnormal_neuron_morphology1.32789127
38MP0004019_abnormal_vitamin_homeostasis1.31743139
39MP0001485_abnormal_pinna_reflex1.24205640
40MP0003122_maternal_imprinting1.22300982
41MP0001984_abnormal_olfaction1.21718568
42MP0005389_reproductive_system_phenotype1.15059445
43MP0003136_yellow_coat_color1.13385320
44MP0008995_early_reproductive_senescence1.11863064
45MP0000427_abnormal_hair_cycle1.11800859
46MP0003718_maternal_effect1.11546460
47MP0001502_abnormal_circadian_rhythm1.11090753
48MP0006292_abnormal_olfactory_placode1.09213547
49MP0005197_abnormal_uvea_morphology1.05099433
50MP0001970_abnormal_pain_threshold1.04098532
51MP0005379_endocrine/exocrine_gland_phen1.01465656
52MP0002733_abnormal_thermal_nociception1.00521284
53MP0003698_abnormal_male_reproductive0.96877577
54MP0009379_abnormal_foot_pigmentation0.96284599
55MP0002909_abnormal_adrenal_gland0.94370398
56MP0002095_abnormal_skin_pigmentation0.93044005
57MP0002735_abnormal_chemical_nociception0.92677528
58MP0004885_abnormal_endolymph0.92362861
59MP0005499_abnormal_olfactory_system0.91698011
60MP0005394_taste/olfaction_phenotype0.91698011
61MP0005377_hearing/vestibular/ear_phenot0.89800325
62MP0003878_abnormal_ear_physiology0.89800325
63MP0005167_abnormal_blood-brain_barrier0.89661534
64MP0003119_abnormal_digestive_system0.89353606
65MP0001929_abnormal_gametogenesis0.87085132
66MP0004233_abnormal_muscle_weight0.87006641
67MP0000049_abnormal_middle_ear0.85820947
68MP0002127_abnormal_cardiovascular_syste0.85587583
69MP0001919_abnormal_reproductive_system0.84783291
70MP0005085_abnormal_gallbladder_physiolo0.84397565
71MP0002751_abnormal_autonomic_nervous0.81777709
72MP0005174_abnormal_tail_pigmentation0.80897316
73MP0008789_abnormal_olfactory_epithelium0.79078688
74MP0001486_abnormal_startle_reflex0.78518632
75MP0002272_abnormal_nervous_system0.76194502
76MP0004270_analgesia0.75808445
77MP0002332_abnormal_exercise_endurance0.74105445
78MP0005187_abnormal_penis_morphology0.69747017
79MP0003880_abnormal_central_pattern0.60107897
80MP0001286_abnormal_eye_development0.59283965
81* MP0003634_abnormal_glial_cell0.55737982
82MP0002734_abnormal_mechanical_nocicepti0.54734710
83MP0009046_muscle_twitch0.52078082
84MP0002064_seizures0.49761702
85MP0001963_abnormal_hearing_physiology0.48339879
86MP0000465_gastrointestinal_hemorrhage0.47697572
87MP0004782_abnormal_surfactant_physiolog0.45646260
88MP0003635_abnormal_synaptic_transmissio0.44842590
89MP0004859_abnormal_synaptic_plasticity0.44761886
90MP0008004_abnormal_stomach_pH0.44037753
91MP0005376_homeostasis/metabolism_phenot0.43614291
92MP0002067_abnormal_sensory_capabilities0.38546380
93MP0002063_abnormal_learning/memory/cond0.34422038
94MP0004742_abnormal_vestibular_system0.34403207
95MP0002572_abnormal_emotion/affect_behav0.33789124
96MP0001968_abnormal_touch/_nociception0.33731574
97MP0009745_abnormal_behavioral_response0.33177160
98MP0004215_abnormal_myocardial_fiber0.32431914
99MP0003045_fibrosis0.32143634
100MP0004145_abnormal_muscle_electrophysio0.30671855
101MP0005248_abnormal_Harderian_gland0.29151657
102MP0002697_abnormal_eye_size0.28985220
103MP0005386_behavior/neurological_phenoty0.28927625
104MP0004924_abnormal_behavior0.28927625
105MP0000026_abnormal_inner_ear0.28230568
106MP0005595_abnormal_vascular_smooth0.27697787
107MP0010386_abnormal_urinary_bladder0.27681442
108MP0004085_abnormal_heartbeat0.27465707
109MP0000631_abnormal_neuroendocrine_gland0.27405069
110MP0004142_abnormal_muscle_tone0.26901660
111MP0005193_abnormal_anterior_eye0.26843278
112MP0005620_abnormal_muscle_contractility0.24827260
113MP0002102_abnormal_ear_morphology0.22161189
114MP0002184_abnormal_innervation0.21606232
115MP0004043_abnormal_pH_regulation0.21373047
116MP0001905_abnormal_dopamine_level0.20943663
117MP0003943_abnormal_hepatobiliary_system0.20820453
118MP0009780_abnormal_chondrocyte_physiolo0.20582921
119MP0008569_lethality_at_weaning0.20371288
120MP0002928_abnormal_bile_duct0.19953518
121MP0000569_abnormal_digit_pigmentation0.19614749
122MP0005076_abnormal_cell_differentiation0.19370790
123MP0001915_intracranial_hemorrhage0.18945609
124MP0008058_abnormal_DNA_repair0.18894404
125MP0004811_abnormal_neuron_physiology0.18185322
126MP0002152_abnormal_brain_morphology0.17998020
127MP0005646_abnormal_pituitary_gland0.17935817
128MP0002066_abnormal_motor_capabilities/c0.17644194
129MP0003633_abnormal_nervous_system0.13532493
130MP0005257_abnormal_intraocular_pressure0.13266643
131MP0003638_abnormal_response/metabolism_0.13145934
132MP0003646_muscle_fatigue0.12828882
133MP0002557_abnormal_social/conspecific_i0.12392420
134MP0003252_abnormal_bile_duct0.12201750
135MP0001661_extended_life_span0.11473580
136MP0002108_abnormal_muscle_morphology0.11441643
137MP0003890_abnormal_embryonic-extraembry0.10890786
138MP0005310_abnormal_salivary_gland0.10540936
139MP0003632_abnormal_nervous_system0.09939671
140MP0001501_abnormal_sleep_pattern0.09861342
141MP0005084_abnormal_gallbladder_morpholo0.09830282
142MP0000778_abnormal_nervous_system0.08772595
143MP0000230_abnormal_systemic_arterial0.08736689
144MP0003631_nervous_system_phenotype0.08702486
145MP0001177_atelectasis0.08340419

Predicted human phenotypes

RankGene SetZ-score
1* Abnormal rod and cone electroretinograms (HP:0008323)9.91640155
2* Absent rod-and cone-mediated responses on ERG (HP:0007688)9.61484625
3Chorioretinal atrophy (HP:0000533)9.22582583
4Dyschromatopsia (HP:0007641)8.60798557
5Central scotoma (HP:0000603)8.43299320
6Abnormality of macular pigmentation (HP:0008002)7.71669294
7Scotoma (HP:0000575)7.50984850
8Abolished electroretinogram (ERG) (HP:0000550)7.21381014
9* Attenuation of retinal blood vessels (HP:0007843)6.63153366
10* Pendular nystagmus (HP:0012043)6.36121373
11Type II diabetes mellitus (HP:0005978)5.94736233
12Vitreoretinal degeneration (HP:0000655)5.78882553
13* Photophobia (HP:0000613)5.75320770
14Severe visual impairment (HP:0001141)5.30720328
15* Decreased central vision (HP:0007663)5.14679651
16Cone-rod dystrophy (HP:0000548)4.71857854
17Retinitis pigmentosa (HP:0000510)4.63312043
18* Macular degeneration (HP:0000608)4.57309491
19Choroideremia (HP:0001139)4.46977882
20Constricted visual fields (HP:0001133)4.46764664
21Posterior subcapsular cataract (HP:0007787)4.42611308
22Decreased electroretinogram (ERG) amplitude (HP:0000654)3.90495814
23* Keratoconus (HP:0000563)3.74207447
24* Increased corneal curvature (HP:0100692)3.74207447
25Progressive visual loss (HP:0000529)3.28910619
26Type II lissencephaly (HP:0007260)3.20852050
27Retinal atrophy (HP:0001105)2.91983903
28Abnormality of alanine metabolism (HP:0010916)2.81020648
29Hyperalaninemia (HP:0003348)2.81020648
30Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.81020648
31Abnormality of the renal medulla (HP:0100957)2.76056098
32Abnormality of the renal cortex (HP:0011035)2.71071415
33Acute necrotizing encephalopathy (HP:0006965)2.70908208
34Wide nasal bridge (HP:0000431)2.67642937
35Subcapsular cataract (HP:0000523)2.65017201
36Hyperventilation (HP:0002883)2.59220737
37Lissencephaly (HP:0001339)2.58903535
38Acute encephalopathy (HP:0006846)2.52594112
39Congenital sensorineural hearing impairment (HP:0008527)2.48605334
40Gait imbalance (HP:0002141)2.44932680
41Congenital primary aphakia (HP:0007707)2.44051914
42Progressive macrocephaly (HP:0004481)2.42229584
43Inability to walk (HP:0002540)2.39319622
44Tubular atrophy (HP:0000092)2.35737473
45Mitochondrial inheritance (HP:0001427)2.34638994
46Renal cortical cysts (HP:0000803)2.33763142
47Abnormal mitochondria in muscle tissue (HP:0008316)2.28879602
48Abnormal drinking behavior (HP:0030082)2.27658281
49Polydipsia (HP:0001959)2.27658281
50Optic nerve hypoplasia (HP:0000609)2.27257352
51Absent/shortened dynein arms (HP:0200106)2.25232920
52Dynein arm defect of respiratory motile cilia (HP:0012255)2.25232920
53Increased CSF lactate (HP:0002490)2.25055897
54Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.20999703
55Gaze-evoked nystagmus (HP:0000640)2.19758622
56Nephrogenic diabetes insipidus (HP:0009806)2.19564606
57* Optic disc pallor (HP:0000543)2.16158233
58Agitation (HP:0000713)2.10763741
59Medial flaring of the eyebrow (HP:0010747)2.08187700
60Concave nail (HP:0001598)2.07832675
61Abnormality of the labia minora (HP:0012880)2.06632405
62Retinal dysplasia (HP:0007973)2.05847447
63Abnormal respiratory epithelium morphology (HP:0012253)2.03738800
64Abnormal respiratory motile cilium morphology (HP:0005938)2.03738800
65Hypothermia (HP:0002045)2.01007300
66Congenital stationary night blindness (HP:0007642)16.4178065
67Bony spicule pigmentary retinopathy (HP:0007737)12.1162931
68Pigmentary retinal degeneration (HP:0001146)10.0476635
69Dyskinesia (HP:0100660)1.98760704
70Methylmalonic aciduria (HP:0012120)1.92079394
71Focal motor seizures (HP:0011153)1.90714399
72Pachygyria (HP:0001302)1.90378923
73Limb dystonia (HP:0002451)1.89940387
74Oligodactyly (hands) (HP:0001180)1.86904956
75Methylmalonic acidemia (HP:0002912)1.86800872
76Aplasia/Hypoplasia of the spleen (HP:0010451)1.86464629
77Interstitial pulmonary disease (HP:0006530)1.85842815
78Broad-based gait (HP:0002136)1.85264105
79Lipid accumulation in hepatocytes (HP:0006561)1.85089345
80Poor coordination (HP:0002370)1.84722444
81Hyperglycinemia (HP:0002154)1.82782664
82Polyuria (HP:0000103)1.80185888
83Hypomagnesemia (HP:0002917)1.78840353
84Increased hepatocellular lipid droplets (HP:0006565)1.78761425
85Male pseudohermaphroditism (HP:0000037)1.78111595
86True hermaphroditism (HP:0010459)1.77829647
87Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.76893420
88Hemiparesis (HP:0001269)1.75811629
89Intestinal atresia (HP:0011100)1.73409573
90Progressive inability to walk (HP:0002505)1.72868715
91Aplasia/hypoplasia of the uterus (HP:0008684)1.72073040
92Large for gestational age (HP:0001520)1.69332723
93Thyroiditis (HP:0100646)1.68905857
94Occipital encephalocele (HP:0002085)1.68808019
953-Methylglutaconic aciduria (HP:0003535)1.67148913
96Hepatocellular necrosis (HP:0001404)1.67081047
97Hyperglycinuria (HP:0003108)1.66313591
98Vaginal atresia (HP:0000148)1.65242583
99* Optic atrophy (HP:0000648)1.63283179
100Genital tract atresia (HP:0001827)1.59148665
101Pancreatic fibrosis (HP:0100732)1.49497654
102Hypoplasia of the fovea (HP:0007750)1.48497368
103Aplasia/Hypoplasia of the fovea (HP:0008060)1.48497368
104Abnormality of the fovea (HP:0000493)1.46711005
105Horizontal nystagmus (HP:0000666)1.45437141
106Aplasia/Hypoplasia of the lens (HP:0008063)1.41944328
107Polar cataract (HP:0010696)1.40903046
108Severe Myopia (HP:0011003)1.38187932
109Cystic liver disease (HP:0006706)1.22916682
110Retinal detachment (HP:0000541)1.21586229
111Pancreatic cysts (HP:0001737)1.21087347
112Epileptic encephalopathy (HP:0200134)1.20506848
113Astigmatism (HP:0000483)1.16592595
114Recurrent sinusitis (HP:0011108)1.15756334
115Dysdiadochokinesis (HP:0002075)1.14658820
116Aplasia/Hypoplasia of the macula (HP:0008059)1.12591997
117Febrile seizures (HP:0002373)1.10776121
118Aplasia/Hypoplasia of the tongue (HP:0010295)1.04741816
119Visual hallucinations (HP:0002367)1.01437402
120Aplasia/Hypoplasia affecting the retina (HP:0008061)1.00688542
121Chorioretinal coloboma (HP:0000567)1.00551610
122Broad foot (HP:0001769)0.99862132
123Specific learning disability (HP:0001328)0.98679315
124Left ventricular hypertrophy (HP:0001712)0.97691650
125Decreased testicular size (HP:0008734)0.94173718
126Sclerocornea (HP:0000647)0.93393479
127Cerebellar dysplasia (HP:0007033)0.91055795
128Hypermetropia (HP:0000540)0.90008347
129Asthma (HP:0002099)0.89439967
130Furrowed tongue (HP:0000221)0.85231865
131Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)0.82158751
132Truncal ataxia (HP:0002078)0.81951303
133Progressive cerebellar ataxia (HP:0002073)0.80610731
134Lymphopenia (HP:0001888)0.80193019
135Albinism (HP:0001022)0.75461114
136Prolonged QT interval (HP:0001657)0.75213386
137Abnormality of midbrain morphology (HP:0002418)0.74247858
138Molar tooth sign on MRI (HP:0002419)0.74247858
139Anencephaly (HP:0002323)0.73087677
140Abnormality of cells of the lymphoid lineage (HP:0012140)0.72043095
141Partial agenesis of the corpus callosum (HP:0001338)0.72003387
142Postaxial hand polydactyly (HP:0001162)0.71661437
143Congenital hepatic fibrosis (HP:0002612)0.70195340
144Abnormality of dental color (HP:0011073)0.68023294
145Chronic hepatic failure (HP:0100626)0.67166110
146Dental crowding (HP:0000678)0.66023147
147Hypodontia (HP:0000668)0.64703204
148Short foot (HP:0001773)0.64319621
149Corneal dystrophy (HP:0001131)0.63537538
150Postaxial foot polydactyly (HP:0001830)0.61905143
151Abnormality of the fingertips (HP:0001211)0.61683167
152Septo-optic dysplasia (HP:0100842)0.61196313
153Nephronophthisis (HP:0000090)0.61020803
154Abnormal EKG (HP:0003115)0.58067494
155Nephrotic syndrome (HP:0000100)0.56937498
156Aqueductal stenosis (HP:0002410)0.55161641
157Hirsutism (HP:0001007)0.55057370

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PBK7.16611962
2FRK4.58039479
3WNK33.20311351
4MAP4K23.14545527
5ADRBK22.97200421
6PINK12.73383648
7BMPR1B2.59817921
8ZAK2.39474339
9WNK42.29216215
10MAPK132.26647242
11IRAK22.25769885
12GRK111.4318783
13SIK21.98600008
14NUAK11.90258099
15BRD41.80877437
16INSRR1.80779360
17CCNB11.65961715
18ACVR1B1.58512569
19OXSR11.53969724
20DYRK21.46966825
21ADRBK11.46481939
22TAOK31.42292364
23TRIM281.42106922
24TLK11.35673296
25RPS6KA41.35617424
26MAPK71.35459001
27CAMK1G1.34619668
28PAK31.31350149
29CDK121.30489747
30MAP3K101.26769793
31STK391.25879097
32VRK21.21536324
33PTK2B1.19860475
34CAMK1D1.19208132
35HIPK21.16538981
36DAPK21.14629496
37PAK61.14523714
38EIF2AK31.13809314
39TIE11.12961467
40BCKDK1.10470577
41STK381.09974332
42MAPK121.08160186
43CSNK1G31.06852484
44SGK2231.04495291
45SGK4941.04495291
46WEE11.03605804
47CSNK1G21.03328239
48MAP3K41.01922209
49PRKCZ1.00978261
50PRKCE1.00611100
51MKNK21.00115002
52CSNK1G10.97389010
53TGFBR10.95339272
54EPHA40.95171150
55CSNK1D0.94906231
56ICK0.93776186
57CDK30.91762134
58MARK10.89774306
59BCR0.89155146
60CSNK1A1L0.88697257
61ERBB20.85239211
62PLK20.84482978
63NEK10.84459375
64PRKCH0.84289036
65SGK20.83939942
66VRK10.83692516
67MST40.82842889
68GRK50.82099964
69NEK20.81591669
70MAPKAPK50.80405791
71CAMKK20.78154203
72STK38L0.77281911
73PLK40.75332128
74CAMKK10.71292696
75NME10.71005817
76PRKD30.70998499
77PRKCI0.70267107
78SGK30.70261326
79DYRK1A0.68630312
80PRKCB0.67964376
81WNK10.67741322
82AKT30.66237954
83PRKAA10.65858788
84MAP2K70.65800589
85PRPF4B0.65105783
86STK30.63593368
87PIK3CA0.62276759
88FGFR20.62070791
89TTK0.61624450
90PRKACG0.60978864
91DYRK30.60915535
92PNCK0.59466637
93TXK0.55975200
94PHKG20.53204567
95PHKG10.53204567
96RPS6KA30.52513173
97PRKAA20.52113734
98FES0.51348705
99MYLK0.51152351
100NEK60.50070962
101MUSK0.47911105
102TNK20.47576973
103CAMK2D0.47369605
104PLK30.47128055
105SIK30.45938600
106OBSCN0.45722166
107MAPK150.45707717
108MAP2K60.44633959
109PRKDC0.44037394
110CAMK10.43901995
111CSNK1A10.43871517
112SGK10.42566118
113GSK3B0.41811011
114IKBKB0.41437634
115SIK10.41213841
116PRKCG0.41158822
117LATS10.40674604
118MAPK140.40191621
119TSSK60.40080221
120CDK90.40033996
121PRKD20.39913159
122SCYL20.39635971
123MKNK10.39495093
124PRKCQ0.39131101
125MAPKAPK30.38910234
126FER0.38433167
127CAMK2A0.37736962
128MAPK90.37120267
129BRSK20.36997927
130AKT20.35728726
131PLK10.35680459
132CAMK40.34887081
133CHEK20.34478577
134DYRK1B0.34280836
135MAPK100.33801151
136TNIK0.33521838
137GRK70.32860602
138CDK50.32603206
139CDK10.32597033
140PRKCA0.31671202
141PRKACA0.30691166
142YES10.29823798
143RPS6KA60.28860276
144RPS6KA50.28231918
145PRKG10.28102524
146NTRK20.27650419
147MAP3K70.26935110
148RPS6KB10.26507670
149PKN10.26459320
150ERBB30.26370009
151STK110.25724018
152KIT0.25072028
153ATR0.24072133
154CSNK2A10.23898793
155PDGFRB0.23409700
156NTRK30.23279631
157PIK3CG0.22895459
158ATM0.22859224
159TYRO30.22735935
160CHEK10.22524355
161TEC0.22331173
162ALK0.21694550
163CASK0.21438908
164CHUK0.20815090

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.85399108
2Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.83335479
3Oxidative phosphorylation_Homo sapiens_hsa001902.65200922
4Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.39229373
5Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.26597757
6Butanoate metabolism_Homo sapiens_hsa006502.13362510
7Parkinsons disease_Homo sapiens_hsa050122.04109579
8Protein export_Homo sapiens_hsa030602.02174515
9Phototransduction_Homo sapiens_hsa0474416.0417712
10Selenocompound metabolism_Homo sapiens_hsa004501.85242723
11Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.83779561
12RNA polymerase_Homo sapiens_hsa030201.72334485
13Ether lipid metabolism_Homo sapiens_hsa005651.61507791
14Synaptic vesicle cycle_Homo sapiens_hsa047211.60566563
15Tryptophan metabolism_Homo sapiens_hsa003801.59053011
16Homologous recombination_Homo sapiens_hsa034401.54968836
17Olfactory transduction_Homo sapiens_hsa047401.52870707
18Propanoate metabolism_Homo sapiens_hsa006401.47351403
19Huntingtons disease_Homo sapiens_hsa050161.38251428
20Alzheimers disease_Homo sapiens_hsa050101.33249139
21Basal transcription factors_Homo sapiens_hsa030221.31944527
22GABAergic synapse_Homo sapiens_hsa047271.24297021
23Fanconi anemia pathway_Homo sapiens_hsa034601.10592736
24Sulfur relay system_Homo sapiens_hsa041221.07130182
25Peroxisome_Homo sapiens_hsa041461.06934686
26One carbon pool by folate_Homo sapiens_hsa006701.05272084
27Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.04709057
28Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.01444691
29Steroid hormone biosynthesis_Homo sapiens_hsa001400.99762346
30Primary bile acid biosynthesis_Homo sapiens_hsa001200.99553190
31Ribosome_Homo sapiens_hsa030100.98887427
32Arachidonic acid metabolism_Homo sapiens_hsa005900.97470296
33Steroid biosynthesis_Homo sapiens_hsa001000.97072572
34Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.93726532
35Cholinergic synapse_Homo sapiens_hsa047250.91001727
36Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.90666283
37Morphine addiction_Homo sapiens_hsa050320.87451267
38Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.87395386
39Chemical carcinogenesis_Homo sapiens_hsa052040.86859093
40beta-Alanine metabolism_Homo sapiens_hsa004100.85425219
41Retinol metabolism_Homo sapiens_hsa008300.85070713
42Proteasome_Homo sapiens_hsa030500.82565166
43Circadian entrainment_Homo sapiens_hsa047130.82371448
44Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.80235555
45Glutamatergic synapse_Homo sapiens_hsa047240.79602690
46Sulfur metabolism_Homo sapiens_hsa009200.79006068
47Fat digestion and absorption_Homo sapiens_hsa049750.78461583
48Non-homologous end-joining_Homo sapiens_hsa034500.75765928
49Circadian rhythm_Homo sapiens_hsa047100.75606443
50Dopaminergic synapse_Homo sapiens_hsa047280.75139970
51Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.74987998
52Metabolic pathways_Homo sapiens_hsa011000.74127249
53Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.72412229
54Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.70442473
55Nitrogen metabolism_Homo sapiens_hsa009100.68414373
56Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.67561075
57Intestinal immune network for IgA production_Homo sapiens_hsa046720.66921455
58Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.66334345
59Serotonergic synapse_Homo sapiens_hsa047260.65938405
60Arginine and proline metabolism_Homo sapiens_hsa003300.61512849
61Pentose and glucuronate interconversions_Homo sapiens_hsa000400.59089982
62Pyrimidine metabolism_Homo sapiens_hsa002400.56305840
63Nicotine addiction_Homo sapiens_hsa050330.55604701
64ABC transporters_Homo sapiens_hsa020100.55293558
65Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.53424997
66Insulin secretion_Homo sapiens_hsa049110.52553653
67Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.52487904
68Cysteine and methionine metabolism_Homo sapiens_hsa002700.50837737
69Regulation of autophagy_Homo sapiens_hsa041400.50421484
70Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.50416457
71cGMP-PKG signaling pathway_Homo sapiens_hsa040220.50143562
72Primary immunodeficiency_Homo sapiens_hsa053400.48636392
73Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.48328300
74Histidine metabolism_Homo sapiens_hsa003400.48323432
75Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.46122629
76Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.43269306
77Purine metabolism_Homo sapiens_hsa002300.42033351
78Carbohydrate digestion and absorption_Homo sapiens_hsa049730.40266975
79Asthma_Homo sapiens_hsa053100.39730620
80Oxytocin signaling pathway_Homo sapiens_hsa049210.39461960
81Caffeine metabolism_Homo sapiens_hsa002320.39340635
82Fructose and mannose metabolism_Homo sapiens_hsa000510.38887666
83Phosphatidylinositol signaling system_Homo sapiens_hsa040700.38437715
84Hedgehog signaling pathway_Homo sapiens_hsa043400.37616738
85Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.36050253
86Aldosterone synthesis and secretion_Homo sapiens_hsa049250.35840159
87Fatty acid degradation_Homo sapiens_hsa000710.35610633
88Vitamin digestion and absorption_Homo sapiens_hsa049770.35525355
89cAMP signaling pathway_Homo sapiens_hsa040240.34501556
90Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.34430530
91SNARE interactions in vesicular transport_Homo sapiens_hsa041300.34403972
92Inositol phosphate metabolism_Homo sapiens_hsa005620.33798887
93Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.32025734
94Dilated cardiomyopathy_Homo sapiens_hsa054140.30872845
95Folate biosynthesis_Homo sapiens_hsa007900.29976267
96RNA transport_Homo sapiens_hsa030130.29804148
97Renin secretion_Homo sapiens_hsa049240.28679358
98mTOR signaling pathway_Homo sapiens_hsa041500.28639124
99Salivary secretion_Homo sapiens_hsa049700.27679693
100Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.25909132
101Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.25873213
102Type I diabetes mellitus_Homo sapiens_hsa049400.25422960
103Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.25131319
104Chemokine signaling pathway_Homo sapiens_hsa040620.24734736
105Type II diabetes mellitus_Homo sapiens_hsa049300.24547211
106Thyroid hormone signaling pathway_Homo sapiens_hsa049190.24351185
107Cardiac muscle contraction_Homo sapiens_hsa042600.24187824
108Gastric acid secretion_Homo sapiens_hsa049710.22232221
109Drug metabolism - other enzymes_Homo sapiens_hsa009830.21801065
110Glycerophospholipid metabolism_Homo sapiens_hsa005640.20925496
111Glycerolipid metabolism_Homo sapiens_hsa005610.20761625
112Central carbon metabolism in cancer_Homo sapiens_hsa052300.20359660
113HIF-1 signaling pathway_Homo sapiens_hsa040660.19891846
114Arginine biosynthesis_Homo sapiens_hsa002200.19597972
115Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.19075484
116Alcoholism_Homo sapiens_hsa050340.17740869
117Lysine degradation_Homo sapiens_hsa003100.17687273
118Galactose metabolism_Homo sapiens_hsa000520.17508995
119Cocaine addiction_Homo sapiens_hsa050300.17345098
120Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.17280236
121Long-term potentiation_Homo sapiens_hsa047200.16053339
122Calcium signaling pathway_Homo sapiens_hsa040200.14830734
123mRNA surveillance pathway_Homo sapiens_hsa030150.14763158
124Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.14003019
125Fatty acid elongation_Homo sapiens_hsa000620.13689346
126Glucagon signaling pathway_Homo sapiens_hsa049220.13596822
127Ras signaling pathway_Homo sapiens_hsa040140.13120575
128Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.12730670
129Maturity onset diabetes of the young_Homo sapiens_hsa049500.12452065
130Longevity regulating pathway - mammal_Homo sapiens_hsa042110.11882224
131Biosynthesis of amino acids_Homo sapiens_hsa012300.10482572
132Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.10205650
133AMPK signaling pathway_Homo sapiens_hsa041520.09977458
134Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.09854945
135GnRH signaling pathway_Homo sapiens_hsa049120.09487286
136Vascular smooth muscle contraction_Homo sapiens_hsa042700.08944479
137Amphetamine addiction_Homo sapiens_hsa050310.08698411
138Taste transduction_Homo sapiens_hsa047420.08566482
139Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.07931234
140Collecting duct acid secretion_Homo sapiens_hsa049660.07424957
141Pancreatic secretion_Homo sapiens_hsa049720.07337589
142Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.07084837
143MAPK signaling pathway_Homo sapiens_hsa040100.06814675
144Phospholipase D signaling pathway_Homo sapiens_hsa040720.06616564
145Insulin resistance_Homo sapiens_hsa049310.04956098
146Notch signaling pathway_Homo sapiens_hsa043300.04778883
147RNA degradation_Homo sapiens_hsa030180.04312577
148Bile secretion_Homo sapiens_hsa049760.04272676
149Mineral absorption_Homo sapiens_hsa049780.03749645
150Glioma_Homo sapiens_hsa052140.03548360
151Choline metabolism in cancer_Homo sapiens_hsa052310.03527287
152Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.03144553
153Thyroid hormone synthesis_Homo sapiens_hsa049180.02894308
154Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.02480160
155alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.02409847
156PI3K-Akt signaling pathway_Homo sapiens_hsa041510.02389002
157Ovarian steroidogenesis_Homo sapiens_hsa049130.02143422
158Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.02077851
159Linoleic acid metabolism_Homo sapiens_hsa005910.01899810
160Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.00782094
161Wnt signaling pathway_Homo sapiens_hsa043100.00693684
162Tight junction_Homo sapiens_hsa04530-0.0028808

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