AHI1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is apparently required for both cerebellar and cortical development in humans. This gene mutations cause specific forms of Joubert syndrome-related disorders. Joubert syndrome (JS) is a recessively inherited developmental brain disorder with several identified causative chromosomal loci. Alternatively spliced transcript variants encoding different isoforms have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.73069959
2neuron cell-cell adhesion (GO:0007158)5.49541697
3vocalization behavior (GO:0071625)5.35658526
4positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.14511208
5synaptic vesicle exocytosis (GO:0016079)4.91120039
6regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.86201308
7ionotropic glutamate receptor signaling pathway (GO:0035235)4.75905194
8protein localization to synapse (GO:0035418)4.72702131
9positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.70514842
10regulation of glutamate receptor signaling pathway (GO:1900449)4.67774470
11synaptic vesicle maturation (GO:0016188)4.67459604
12locomotory exploration behavior (GO:0035641)4.64082708
13regulation of synaptic vesicle exocytosis (GO:2000300)4.51987062
14regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.36445050
15glutamate receptor signaling pathway (GO:0007215)4.33067648
16neuron recognition (GO:0008038)4.31514155
17neurotransmitter secretion (GO:0007269)4.30017598
18glutamate secretion (GO:0014047)4.19994915
19exploration behavior (GO:0035640)4.08314358
20gamma-aminobutyric acid signaling pathway (GO:0007214)4.07208117
21regulation of synaptic vesicle transport (GO:1902803)4.06693114
22transmission of nerve impulse (GO:0019226)3.98069094
23synaptic transmission, glutamatergic (GO:0035249)3.92445387
24epithelial cilium movement (GO:0003351)3.91413214
25positive regulation of synaptic transmission, GABAergic (GO:0032230)3.91196225
26neuron-neuron synaptic transmission (GO:0007270)3.87267376
27neurotransmitter transport (GO:0006836)3.85565339
28neuronal action potential propagation (GO:0019227)3.83925437
29gamma-aminobutyric acid transport (GO:0015812)3.82428830
30axonal fasciculation (GO:0007413)3.79813297
31layer formation in cerebral cortex (GO:0021819)3.79593372
32neuromuscular process controlling posture (GO:0050884)3.76684202
33response to histamine (GO:0034776)3.75050470
34regulation of neuronal synaptic plasticity (GO:0048168)3.74670965
35regulation of long-term neuronal synaptic plasticity (GO:0048169)3.74118563
36dendritic spine morphogenesis (GO:0060997)3.73694002
37proline transport (GO:0015824)3.73561667
38regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.71593777
39mating behavior (GO:0007617)3.65884914
40long-term memory (GO:0007616)3.64519921
41postsynaptic membrane organization (GO:0001941)3.55445023
42regulation of glutamate secretion (GO:0014048)3.55070805
43epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.54995350
44presynaptic membrane assembly (GO:0097105)3.53806898
45regulation of neurotransmitter levels (GO:0001505)3.50845463
46regulation of vesicle fusion (GO:0031338)3.48700471
47cilium movement (GO:0003341)3.48311129
48activation of protein kinase A activity (GO:0034199)3.46826478
49synaptic vesicle endocytosis (GO:0048488)3.45596923
50regulation of excitatory postsynaptic membrane potential (GO:0060079)3.44846269
51positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.44162900
52negative regulation of synaptic transmission, GABAergic (GO:0032229)3.43430889
53regulation of postsynaptic membrane potential (GO:0060078)3.43367955
54negative regulation of cytosolic calcium ion concentration (GO:0051481)3.42262538
55regulation of protein kinase A signaling (GO:0010738)3.36016710
56positive regulation of synapse assembly (GO:0051965)3.33817373
57neurotransmitter-gated ion channel clustering (GO:0072578)3.32241188
58regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.28274314
59positive regulation of membrane potential (GO:0045838)3.27782836
60membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.27392050
61G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.26031051
62presynaptic membrane organization (GO:0097090)3.25603328
63synaptic vesicle docking involved in exocytosis (GO:0016081)3.24370282
64regulation of synapse structural plasticity (GO:0051823)3.22663091
65cerebellar Purkinje cell differentiation (GO:0021702)3.21910537
66startle response (GO:0001964)3.19714830
67regulation of synaptic transmission, glutamatergic (GO:0051966)3.18623298
68synapse assembly (GO:0007416)3.17712434
69behavioral defense response (GO:0002209)3.17436403
70behavioral fear response (GO:0001662)3.17436403
71cellular potassium ion homeostasis (GO:0030007)3.17355999
72regulation of neurotransmitter uptake (GO:0051580)3.15194812
73membrane hyperpolarization (GO:0060081)3.15053584
74membrane depolarization during action potential (GO:0086010)3.13778229
75vesicle transport along microtubule (GO:0047496)3.13139364
76social behavior (GO:0035176)3.11337588
77intraspecies interaction between organisms (GO:0051703)3.11337588
78neurotransmitter catabolic process (GO:0042135)3.10406642
79regulation of neurotransmitter secretion (GO:0046928)3.10352575
80righting reflex (GO:0060013)3.10250570
81protein polyglutamylation (GO:0018095)3.09060572
82cilium or flagellum-dependent cell motility (GO:0001539)3.07464731
83regulation of dopamine uptake involved in synaptic transmission (GO:0051584)3.07202373
84regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)3.07202373
85long-term synaptic potentiation (GO:0060291)3.06030515
86membrane depolarization (GO:0051899)3.05700582
87neuronal ion channel clustering (GO:0045161)3.04116286
88fear response (GO:0042596)3.03628925
89protein K11-linked deubiquitination (GO:0035871)3.02234533
90regulation of synaptic transmission, GABAergic (GO:0032228)3.01540213
91negative regulation of amino acid transport (GO:0051956)3.00850390
92negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.99379843
93axoneme assembly (GO:0035082)2.99099807
94dendrite morphogenesis (GO:0048813)2.98779303
95response to auditory stimulus (GO:0010996)2.97741696
96synaptic transmission (GO:0007268)2.96810881
97behavioral response to nicotine (GO:0035095)2.96455439
98regulation of synaptic plasticity (GO:0048167)2.95936501
99positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.95850692
100regulation of glucokinase activity (GO:0033131)2.95794126
101regulation of hexokinase activity (GO:1903299)2.95794126
102response to pheromone (GO:0019236)2.95362809
103cellular ketone body metabolic process (GO:0046950)2.95263284
104learning (GO:0007612)2.94416491
105protein localization to cilium (GO:0061512)2.94414689
106nonmotile primary cilium assembly (GO:0035058)2.93750935
107prepulse inhibition (GO:0060134)2.93749165
108regulation of respiratory system process (GO:0044065)2.92824684
109positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.92519815
110regulation of neurotransmitter transport (GO:0051588)2.91792021
111positive regulation of synapse maturation (GO:0090129)2.91070413
112protein complex biogenesis (GO:0070271)2.90577087
113auditory behavior (GO:0031223)2.90391634
114synapse organization (GO:0050808)2.89147035
115negative regulation of neurotransmitter transport (GO:0051589)2.88861099
116regulation of dendritic spine morphogenesis (GO:0061001)2.88086899
117calcium ion-dependent exocytosis (GO:0017156)2.86606840
118* cilium organization (GO:0044782)2.85212077
119intraciliary transport (GO:0042073)2.83663125
120positive regulation of dendritic spine development (GO:0060999)2.83623505
121regulation of cilium movement (GO:0003352)2.83023915
122positive regulation of potassium ion transmembrane transport (GO:1901381)2.82951158
123retinal cone cell development (GO:0046549)2.81743211
124reflex (GO:0060004)2.79745749
125* cilium assembly (GO:0042384)2.78991264
126L-fucose catabolic process (GO:0042355)2.76076318
127fucose catabolic process (GO:0019317)2.76076318
128L-fucose metabolic process (GO:0042354)2.76076318
129inositol phosphate catabolic process (GO:0071545)2.75084569
130positive regulation of meiosis (GO:0045836)2.72997082
131chemosensory behavior (GO:0007635)2.71923331
132detection of light stimulus involved in sensory perception (GO:0050962)2.71668251
133detection of light stimulus involved in visual perception (GO:0050908)2.71668251
134respiratory chain complex IV assembly (GO:0008535)2.71660353
135detection of chemical stimulus involved in sensory perception of smell (GO:0050911)2.71380820
136acrosome reaction (GO:0007340)2.67778452
137neurofilament cytoskeleton organization (GO:0060052)2.66393176
138insulin secretion (GO:0030073)2.65455907
139seminiferous tubule development (GO:0072520)2.64655755
140cytochrome complex assembly (GO:0017004)2.62474280
141water-soluble vitamin biosynthetic process (GO:0042364)2.62170875
142establishment of protein localization to Golgi (GO:0072600)2.61429837
143detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.61075893
144mitochondrial respiratory chain complex assembly (GO:0033108)2.60853269
145ketone body metabolic process (GO:1902224)2.60245877
146neuronal action potential (GO:0019228)2.59304157
147regulation of calcium ion-dependent exocytosis (GO:0017158)2.56920113
148* cilium morphogenesis (GO:0060271)2.54052049
149positive regulation of meiotic cell cycle (GO:0051446)2.51492260
150urinary tract smooth muscle contraction (GO:0014848)2.50693136
151centriole replication (GO:0007099)2.48692323
152serotonin metabolic process (GO:0042428)2.45706179
153inner ear receptor stereocilium organization (GO:0060122)2.44637517
154detection of calcium ion (GO:0005513)2.44347555
155behavioral response to cocaine (GO:0048148)2.44239340
156protein targeting to Golgi (GO:0000042)2.44066997
157response to amphetamine (GO:0001975)2.43351518
158mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.42918502
159potassium ion transmembrane transport (GO:0071805)2.39634856
160cellular potassium ion transport (GO:0071804)2.39634856
161NADH dehydrogenase complex assembly (GO:0010257)2.36373414
162mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.36373414
163mitochondrial respiratory chain complex I assembly (GO:0032981)2.36373414
164glycosphingolipid biosynthetic process (GO:0006688)2.35936687
165platelet dense granule organization (GO:0060155)2.35848438
166regulation of microtubule-based movement (GO:0060632)2.34264416
167cochlea development (GO:0090102)2.33935857
168synaptic transmission, dopaminergic (GO:0001963)2.33743107
169inositol phosphate dephosphorylation (GO:0046855)2.33682810
170phosphorylated carbohydrate dephosphorylation (GO:0046838)2.33682810
171calcium ion import (GO:0070509)2.33292988
172photoreceptor cell maintenance (GO:0045494)2.32869636
173primary amino compound metabolic process (GO:1901160)2.32711169
174mechanosensory behavior (GO:0007638)2.32169776
175sperm motility (GO:0030317)2.31435198

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.63741723
2GBX2_23144817_ChIP-Seq_PC3_Human3.65197895
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.00313524
4JARID2_20064375_ChIP-Seq_MESCs_Mouse2.92557617
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.88906695
6FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.87047819
7* REST_21632747_ChIP-Seq_MESCs_Mouse2.71202756
8SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.52903803
9CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.49979303
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.48616655
11EZH2_27304074_Chip-Seq_ESCs_Mouse2.47530605
12SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.46828644
13EZH2_18974828_ChIP-Seq_MESCs_Mouse2.45706886
14RNF2_18974828_ChIP-Seq_MESCs_Mouse2.45706886
15TAF15_26573619_Chip-Seq_HEK293_Human2.41344065
16SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.39778388
17SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.39071712
18NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.38445326
19MTF2_20144788_ChIP-Seq_MESCs_Mouse2.36669458
20EED_16625203_ChIP-ChIP_MESCs_Mouse2.30578248
21GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.21903914
22DROSHA_22980978_ChIP-Seq_HELA_Human2.17056411
23IKZF1_21737484_ChIP-ChIP_HCT116_Human2.15838352
24CTBP2_25329375_ChIP-Seq_LNCAP_Human2.13627785
25* REST_18959480_ChIP-ChIP_MESCs_Mouse2.12465600
26SUZ12_27294783_Chip-Seq_ESCs_Mouse2.12424503
27EZH2_27294783_Chip-Seq_ESCs_Mouse2.10595806
28* RARB_27405468_Chip-Seq_BRAIN_Mouse2.05492312
29CTBP1_25329375_ChIP-Seq_LNCAP_Human2.01088447
30SALL1_21062744_ChIP-ChIP_HESCs_Human1.99551108
31RNF2_27304074_Chip-Seq_ESCs_Mouse1.98680341
32ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.95121321
33HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.92851334
34EWS_26573619_Chip-Seq_HEK293_Human1.89077644
35FLI1_27457419_Chip-Seq_LIVER_Mouse1.88371026
36AR_21572438_ChIP-Seq_LNCaP_Human1.87149733
37ZNF274_21170338_ChIP-Seq_K562_Hela1.85309988
38* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.82404066
39BMI1_23680149_ChIP-Seq_NPCS_Mouse1.77153873
40* SMAD4_21799915_ChIP-Seq_A2780_Human1.76579789
41IGF1R_20145208_ChIP-Seq_DFB_Human1.72207203
42P300_19829295_ChIP-Seq_ESCs_Human1.62631163
43GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.59978344
44CBX2_27304074_Chip-Seq_ESCs_Mouse1.59922415
45SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.57929647
46MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.57359979
47PCGF2_27294783_Chip-Seq_ESCs_Mouse1.56568625
48PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.53653656
49SUZ12_27294783_Chip-Seq_NPCs_Mouse1.47296882
50TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.46211682
51RNF2_27304074_Chip-Seq_NSC_Mouse1.44876463
52MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.43792308
53SMAD3_21741376_ChIP-Seq_EPCs_Human1.40399185
54TOP2B_26459242_ChIP-Seq_MCF-7_Human1.39801766
55MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.38709815
56EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.38671669
57* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.37589707
58HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.36991155
59PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.36554647
60* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.35189049
61* EZH2_27294783_Chip-Seq_NPCs_Mouse1.35073621
62FUS_26573619_Chip-Seq_HEK293_Human1.34080242
63ERG_21242973_ChIP-ChIP_JURKAT_Human1.33942874
64MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.33478096
65RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.32913679
66NFE2_27457419_Chip-Seq_LIVER_Mouse1.32903840
67AR_25329375_ChIP-Seq_VCAP_Human1.31252100
68P53_22387025_ChIP-Seq_ESCs_Mouse1.30133247
69SOX2_21211035_ChIP-Seq_LN229_Gbm1.29301914
70NR3C1_23031785_ChIP-Seq_PC12_Mouse1.28502307
71PIAS1_25552417_ChIP-Seq_VCAP_Human1.28036874
72* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.27521321
73PCGF2_27294783_Chip-Seq_NPCs_Mouse1.27442127
74OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.26285980
75TCF4_22108803_ChIP-Seq_LS180_Human1.23924314
76E2F1_18555785_Chip-Seq_ESCs_Mouse1.23475664
77EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.22375044
78RING1B_27294783_Chip-Seq_ESCs_Mouse1.22085334
79* STAT3_23295773_ChIP-Seq_U87_Human1.21691696
80KLF5_20875108_ChIP-Seq_MESCs_Mouse1.21627106
81EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.21146826
82CDX2_19796622_ChIP-Seq_MESCs_Mouse1.20895513
83TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.18690087
84SOX2_19829295_ChIP-Seq_ESCs_Human1.18049328
85NANOG_19829295_ChIP-Seq_ESCs_Human1.18049328
86* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.17978417
87VDR_22108803_ChIP-Seq_LS180_Human1.17809865
88* FLI1_21867929_ChIP-Seq_TH2_Mouse1.16886321
89SUZ12_18555785_Chip-Seq_ESCs_Mouse1.16789938
90UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.15742671
91CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15592298
92ER_23166858_ChIP-Seq_MCF-7_Human1.15427341
93TP53_22573176_ChIP-Seq_HFKS_Human1.15404122
94SMAD4_21741376_ChIP-Seq_EPCs_Human1.14711624
95* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.14487638
96CMYC_18555785_Chip-Seq_ESCs_Mouse1.14020691
97TCF4_23295773_ChIP-Seq_U87_Human1.13808493
98STAT3_18555785_Chip-Seq_ESCs_Mouse1.12820604
99* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.12601316
100SMAD_19615063_ChIP-ChIP_OVARY_Human1.11697247
101RUNX2_22187159_ChIP-Seq_PCA_Human1.10963316
102* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.09882336
103RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.09799059
104TBL1_22424771_ChIP-Seq_293T_Human1.09679273
105AR_19668381_ChIP-Seq_PC3_Human1.09131459
106SOX2_18555785_Chip-Seq_ESCs_Mouse1.06870263
107EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.06826554
108EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.06628777
109AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.06016726
110KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.05134350
111P300_18555785_Chip-Seq_ESCs_Mouse1.05020793
112NR3C1_21868756_ChIP-Seq_MCF10A_Human1.02603475
113* TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.02574724
114TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.01525341
115TAL1_26923725_Chip-Seq_HPCs_Mouse1.01222692
116* JUN_21703547_ChIP-Seq_K562_Human1.00524556
117P53_22127205_ChIP-Seq_FIBROBLAST_Human0.99484625
118NANOG_18555785_Chip-Seq_ESCs_Mouse0.97521717
119BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.97302801
120TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96073216
121PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.95440724
122YAP1_20516196_ChIP-Seq_MESCs_Mouse0.95263076
123* ARNT_22903824_ChIP-Seq_MCF-7_Human0.95015346
124SMAD3_21741376_ChIP-Seq_ESCs_Human0.94917316
125RING1B_27294783_Chip-Seq_NPCs_Mouse0.94286271
126TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93334062
127POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.93334062
128* PRDM14_20953172_ChIP-Seq_ESCs_Human0.93194460
129AHR_22903824_ChIP-Seq_MCF-7_Human0.90776166
130CBP_20019798_ChIP-Seq_JUKART_Human0.90251954
131IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.90251954
132* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.89433360
133BCAT_22108803_ChIP-Seq_LS180_Human0.89295887
134TP53_18474530_ChIP-ChIP_U2OS_Human0.88968540
135DNAJC2_21179169_ChIP-ChIP_NT2_Human0.87839809
136ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.87244103
137TP53_16413492_ChIP-PET_HCT116_Human0.85925399
138KDM2B_26808549_Chip-Seq_REH_Human0.84960523
139* CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.84463213

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern5.23813270
2MP0004859_abnormal_synaptic_plasticity5.08040185
3MP0003635_abnormal_synaptic_transmissio3.81689312
4MP0009745_abnormal_behavioral_response3.34857954
5MP0002064_seizures3.13074021
6MP0009046_muscle_twitch3.07623305
7MP0001968_abnormal_touch/_nociception3.05464393
8MP0002063_abnormal_learning/memory/cond3.02564415
9MP0005423_abnormal_somatic_nervous3.01476324
10MP0004270_analgesia2.92981884
11MP0006276_abnormal_autonomic_nervous2.88832445
12MP0003122_maternal_imprinting2.81608968
13* MP0002572_abnormal_emotion/affect_behav2.71836810
14MP0002272_abnormal_nervous_system2.56543597
15MP0001501_abnormal_sleep_pattern2.55776671
16MP0001440_abnormal_grooming_behavior2.45933973
17MP0002734_abnormal_mechanical_nocicepti2.43325574
18MP0003195_calcinosis2.42809912
19MP0001486_abnormal_startle_reflex2.40354315
20MP0002736_abnormal_nociception_after2.35610077
21MP0005645_abnormal_hypothalamus_physiol2.26104215
22MP0001529_abnormal_vocalization2.22907989
23MP0002822_catalepsy2.15503081
24MP0002735_abnormal_chemical_nociception2.12121657
25MP0002733_abnormal_thermal_nociception2.05348351
26MP0002067_abnormal_sensory_capabilities2.04595945
27MP0001970_abnormal_pain_threshold1.93473644
28MP0002184_abnormal_innervation1.88111447
29MP0002557_abnormal_social/conspecific_i1.85609607
30MP0005646_abnormal_pituitary_gland1.85136173
31MP0005386_behavior/neurological_phenoty1.84324962
32MP0004924_abnormal_behavior1.84324962
33MP0000778_abnormal_nervous_system1.82279071
34MP0004142_abnormal_muscle_tone1.81649821
35MP0001905_abnormal_dopamine_level1.80431829
36MP0003787_abnormal_imprinting1.79464517
37MP0005084_abnormal_gallbladder_morpholo1.77786622
38MP0004133_heterotaxia1.75435605
39MP0004147_increased_porphyrin_level1.74870488
40MP0001984_abnormal_olfaction1.74172212
41MP0006292_abnormal_olfactory_placode1.60936813
42MP0001188_hyperpigmentation1.51720491
43MP0003329_amyloid_beta_deposits1.51446442
44MP0002938_white_spotting1.49735206
45MP0002909_abnormal_adrenal_gland1.47575726
46MP0001502_abnormal_circadian_rhythm1.46625057
47MP0004811_abnormal_neuron_physiology1.45288273
48MP0008569_lethality_at_weaning1.44125060
49MP0000955_abnormal_spinal_cord1.41294961
50MP0002066_abnormal_motor_capabilities/c1.38936755
51* MP0002882_abnormal_neuron_morphology1.38470180
52MP0009780_abnormal_chondrocyte_physiolo1.37233891
53MP0002163_abnormal_gland_morphology1.35934333
54MP0003121_genomic_imprinting1.33049078
55MP0002160_abnormal_reproductive_system1.31610762
56MP0004043_abnormal_pH_regulation1.30705854
57MP0002928_abnormal_bile_duct1.29649375
58MP0001485_abnormal_pinna_reflex1.29587162
59MP0004858_abnormal_nervous_system1.26072538
60MP0000751_myopathy1.24017717
61MP0005174_abnormal_tail_pigmentation1.23575308
62MP0001944_abnormal_pancreas_morphology1.22953245
63* MP0005551_abnormal_eye_electrophysiolog1.20092381
64MP0003123_paternal_imprinting1.19629519
65MP0004145_abnormal_muscle_electrophysio1.17063090
66MP0000372_irregular_coat_pigmentation1.15916428
67MP0000427_abnormal_hair_cycle1.14173387
68MP0004885_abnormal_endolymph1.14091432
69MP0004742_abnormal_vestibular_system1.11313880
70MP0010386_abnormal_urinary_bladder1.10991070
71MP0003879_abnormal_hair_cell1.10728544
72MP0003633_abnormal_nervous_system1.09265138
73MP0002152_abnormal_brain_morphology1.08868390
74MP0002638_abnormal_pupillary_reflex1.06802438
75MP0002837_dystrophic_cardiac_calcinosis1.06175722
76MP0002693_abnormal_pancreas_physiology1.02432948
77MP0008872_abnormal_physiological_respon1.02143516
78MP0000631_abnormal_neuroendocrine_gland1.02086356
79* MP0002229_neurodegeneration1.00538898
80MP0000566_synostosis0.99705506
81MP0008995_early_reproductive_senescence0.97412012
82MP0002069_abnormal_eating/drinking_beha0.97079802
83MP0003631_nervous_system_phenotype0.94974208
84MP0002876_abnormal_thyroid_physiology0.94853562
85MP0000013_abnormal_adipose_tissue0.94177734
86MP0005187_abnormal_penis_morphology0.94002713
87MP0001986_abnormal_taste_sensitivity0.93583127
88MP0005389_reproductive_system_phenotype0.91572268
89MP0003698_abnormal_male_reproductive0.91250229
90MP0000639_abnormal_adrenal_gland0.90362229
91MP0005535_abnormal_body_temperature0.89306123
92MP0002234_abnormal_pharynx_morphology0.88065384
93MP0003634_abnormal_glial_cell0.87624002
94MP0005409_darkened_coat_color0.87231076
95* MP0002752_abnormal_somatic_nervous0.86735725
96MP0003011_delayed_dark_adaptation0.85733306
97MP0001963_abnormal_hearing_physiology0.83627571
98MP0002095_abnormal_skin_pigmentation0.83606247
99MP0005499_abnormal_olfactory_system0.82545684
100MP0005394_taste/olfaction_phenotype0.82545684
101MP0002751_abnormal_autonomic_nervous0.82206952
102MP0005410_abnormal_fertilization0.81415957
103MP0003283_abnormal_digestive_organ0.80725356
104* MP0005195_abnormal_posterior_eye0.80484888
105MP0005448_abnormal_energy_balance0.79123094
106MP0003690_abnormal_glial_cell0.78131272
107MP0004085_abnormal_heartbeat0.78122656
108MP0003890_abnormal_embryonic-extraembry0.77247590
109MP0008877_abnormal_DNA_methylation0.74290089
110MP0001177_atelectasis0.73028506
111MP0008961_abnormal_basal_metabolism0.71297453
112MP0008874_decreased_physiological_sensi0.71090593
113MP0002090_abnormal_vision0.69683872
114MP0001664_abnormal_digestion0.69465909
115MP0003632_abnormal_nervous_system0.68840602
116MP0005379_endocrine/exocrine_gland_phen0.68638951
117MP0000920_abnormal_myelination0.67915608
118* MP0006072_abnormal_retinal_apoptosis0.65369769
119MP0001943_abnormal_respiration0.63032558
120MP0003137_abnormal_impulse_conducting0.62446478
121* MP0005253_abnormal_eye_physiology0.60224998
122MP0001299_abnormal_eye_distance/0.60079652
123MP0002102_abnormal_ear_morphology0.59475739
124MP0004215_abnormal_myocardial_fiber0.59276055
125MP0005623_abnormal_meninges_morphology0.58957170
126MP0000026_abnormal_inner_ear0.58190981
127MP0000569_abnormal_digit_pigmentation0.58027217
128MP0003861_abnormal_nervous_system0.55208848
129MP0000604_amyloidosis0.54904484
130MP0000747_muscle_weakness0.54496270

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.05970535
2Focal seizures (HP:0007359)5.37703335
3Myokymia (HP:0002411)5.36733083
4Visual hallucinations (HP:0002367)5.13463236
5Atonic seizures (HP:0010819)4.59697748
6Epileptic encephalopathy (HP:0200134)4.28566649
7Absence seizures (HP:0002121)4.27244775
8Febrile seizures (HP:0002373)4.25029635
9Progressive cerebellar ataxia (HP:0002073)4.02989356
10Dialeptic seizures (HP:0011146)3.91346605
11Generalized tonic-clonic seizures (HP:0002069)3.87072576
12Pancreatic fibrosis (HP:0100732)3.77721430
13Supranuclear gaze palsy (HP:0000605)3.52690294
14Pancreatic cysts (HP:0001737)3.50846262
15Limb dystonia (HP:0002451)3.44295682
16* Molar tooth sign on MRI (HP:0002419)3.42805915
17* Abnormality of midbrain morphology (HP:0002418)3.42805915
18True hermaphroditism (HP:0010459)3.41344744
19* Nephronophthisis (HP:0000090)3.40109252
20Polyphagia (HP:0002591)3.35024327
21Broad-based gait (HP:0002136)3.28618567
22Abnormal eating behavior (HP:0100738)3.21716107
23Progressive inability to walk (HP:0002505)3.16120105
24Abnormality of the renal cortex (HP:0011035)3.06924675
25Anxiety (HP:0000739)2.98282371
26Hyperinsulinemic hypoglycemia (HP:0000825)2.98064319
27* Abnormality of the renal medulla (HP:0100957)2.95763192
28Chronic hepatic failure (HP:0100626)2.95071749
29Mutism (HP:0002300)2.92616517
30Large for gestational age (HP:0001520)2.92565847
31Truncal ataxia (HP:0002078)2.90763798
32Hyperventilation (HP:0002883)2.89899272
33Abnormal ciliary motility (HP:0012262)2.89328346
34Depression (HP:0000716)2.83208254
35Gait imbalance (HP:0002141)2.82914239
36Drooling (HP:0002307)2.81729454
37Excessive salivation (HP:0003781)2.81729454
38Dynein arm defect of respiratory motile cilia (HP:0012255)2.80696428
39Absent/shortened dynein arms (HP:0200106)2.80696428
40Action tremor (HP:0002345)2.80066512
41Ankle clonus (HP:0011448)2.79261083
42Failure to thrive in infancy (HP:0001531)2.75829682
43Neurofibrillary tangles (HP:0002185)2.71142238
44Dysmetria (HP:0001310)2.69656557
45Dysdiadochokinesis (HP:0002075)2.67226731
46Cerebral inclusion bodies (HP:0100314)2.66324393
47Amblyopia (HP:0000646)2.65157187
48Gaze-evoked nystagmus (HP:0000640)2.63035686
49Agitation (HP:0000713)2.62565567
50Impaired vibration sensation in the lower limbs (HP:0002166)2.61548858
51Abnormal respiratory motile cilium physiology (HP:0012261)2.61431084
52Polyuria (HP:0000103)2.58329826
53Hemiparesis (HP:0001269)2.57546256
54Congenital stationary night blindness (HP:0007642)2.56345158
55Abnormal drinking behavior (HP:0030082)2.55498251
56Polydipsia (HP:0001959)2.55498251
57Pheochromocytoma (HP:0002666)2.52639295
58Postural instability (HP:0002172)2.51740110
59Abnormal respiratory epithelium morphology (HP:0012253)2.51434818
60Abnormal respiratory motile cilium morphology (HP:0005938)2.51434818
61Urinary bladder sphincter dysfunction (HP:0002839)2.50143990
62Acute necrotizing encephalopathy (HP:0006965)2.48378594
63Poor eye contact (HP:0000817)2.48349178
64Abnormal hair whorl (HP:0010721)2.45093850
65Congenital primary aphakia (HP:0007707)2.43618084
66Progressive macrocephaly (HP:0004481)2.41910330
67Papilledema (HP:0001085)2.41488233
68Tubular atrophy (HP:0000092)2.39120333
69Medial flaring of the eyebrow (HP:0010747)2.39075347
70Hypoventilation (HP:0002791)2.38177930
71Volvulus (HP:0002580)2.38070279
72Abnormality of the corticospinal tract (HP:0002492)2.36303776
73Abnormal rod and cone electroretinograms (HP:0008323)2.35309274
74Cystic liver disease (HP:0006706)2.32457366
75Psychosis (HP:0000709)2.31816303
76Spastic gait (HP:0002064)2.31289216
77Intestinal atresia (HP:0011100)2.30722766
78Abnormal social behavior (HP:0012433)2.28175388
79Impaired social interactions (HP:0000735)2.28175388
80Ketoacidosis (HP:0001993)2.27448068
81Diplopia (HP:0000651)2.26519727
82Abnormality of binocular vision (HP:0011514)2.26519727
83Specific learning disability (HP:0001328)2.25338496
84Epileptiform EEG discharges (HP:0011182)2.24262076
85Neuroendocrine neoplasm (HP:0100634)2.23331322
86Renal cortical cysts (HP:0000803)2.22910624
87Bradykinesia (HP:0002067)2.21956562
88Abnormality of the labia minora (HP:0012880)2.20088447
89Nephrogenic diabetes insipidus (HP:0009806)2.19400383
90Absent speech (HP:0001344)2.19383929
91Genetic anticipation (HP:0003743)2.16670049
92EEG with generalized epileptiform discharges (HP:0011198)2.16524143
93Urinary urgency (HP:0000012)2.15209016
94Type II lissencephaly (HP:0007260)2.14226756
95Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.12864617
96Scanning speech (HP:0002168)2.12758914
97Esotropia (HP:0000565)2.12378175
98Inability to walk (HP:0002540)2.11963838
99Mitochondrial inheritance (HP:0001427)2.11781779
100Genital tract atresia (HP:0001827)2.11212330
101Retinal dysplasia (HP:0007973)2.10050021
102Abnormal urine output (HP:0012590)2.09217649
103Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.08316113
104Furrowed tongue (HP:0000221)2.08230692
105Vaginal atresia (HP:0000148)2.08015637
106Impaired smooth pursuit (HP:0007772)2.07209617
107Acute encephalopathy (HP:0006846)2.06839206
108Blue irides (HP:0000635)2.06436266
109Poor coordination (HP:0002370)2.05596760
110Hypoglycemic coma (HP:0001325)2.05125730
111Abnormal mitochondria in muscle tissue (HP:0008316)2.03259494
112Generalized myoclonic seizures (HP:0002123)2.02645107
113Termporal pattern (HP:0011008)2.02156158
114Insidious onset (HP:0003587)2.02156158
115Fetal akinesia sequence (HP:0001989)2.02077832
116Aplasia/Hypoplasia of the tongue (HP:0010295)2.01926347
117Amyotrophic lateral sclerosis (HP:0007354)2.01651300
118Abnormality of the lower motor neuron (HP:0002366)2.01537016
119Hypsarrhythmia (HP:0002521)2.00225320
120Protruding tongue (HP:0010808)2.00045740
121Poor suck (HP:0002033)1.99504389
122Lower limb muscle weakness (HP:0007340)1.99286151
123Hypothermia (HP:0002045)1.98506590
124Narrow nasal bridge (HP:0000446)1.97924408
125Postaxial hand polydactyly (HP:0001162)1.96871633
126Status epilepticus (HP:0002133)1.95757751
127Attenuation of retinal blood vessels (HP:0007843)1.95500183
128Torticollis (HP:0000473)1.95421860
129Rhinitis (HP:0012384)1.95006866
130Tubulointerstitial nephritis (HP:0001970)1.94891525
131Abnormality of renal excretion (HP:0011036)1.93272136
132Abnormality of ocular smooth pursuit (HP:0000617)1.90889834
133Abnormality of salivation (HP:0100755)1.90289875
134Bony spicule pigmentary retinopathy (HP:0007737)1.89904175
135Congenital hepatic fibrosis (HP:0002612)1.88349578
136Postaxial foot polydactyly (HP:0001830)1.88140940
137Hyperthyroidism (HP:0000836)1.88099429
138Sclerocornea (HP:0000647)1.86837284
139Male pseudohermaphroditism (HP:0000037)1.86799913
140Intention tremor (HP:0002080)1.86794382
141Focal dystonia (HP:0004373)1.86089094
142Hypoglycemic seizures (HP:0002173)1.84790388
143Delusions (HP:0000746)1.84158317
144Increased CSF lactate (HP:0002490)1.83361505
145Hypomagnesemia (HP:0002917)1.83174553
146Hemiplegia (HP:0002301)1.83041276
147Optic nerve hypoplasia (HP:0000609)1.82040138
148Thyroiditis (HP:0100646)1.79658141
149Oligodactyly (hands) (HP:0001180)1.79554345
150Hyperglycemia (HP:0003074)1.78484608
151Hepatic necrosis (HP:0002605)1.77597102
152Aplasia/Hypoplasia of the tibia (HP:0005772)1.77586968
153Abnormal biliary tract physiology (HP:0012439)1.75370564
154Bile duct proliferation (HP:0001408)1.75370564
1553-Methylglutaconic aciduria (HP:0003535)1.74970475
156Occipital encephalocele (HP:0002085)1.74608428
157Abnormality of renal resorption (HP:0011038)1.73581012
158Hypoplasia of the fovea (HP:0007750)1.70828444
159Aplasia/Hypoplasia of the fovea (HP:0008060)1.70828444
160Tubulointerstitial abnormality (HP:0001969)1.67442587
161Hypoplastic ischia (HP:0003175)1.65562481

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK35.08278940
2FRK4.54321373
3MAP3K93.55052072
4MARK13.32308228
5EPHA43.15566047
6MAP3K43.11075740
7MAP3K122.95786353
8PNCK2.72696804
9NTRK22.69769022
10MAP2K72.59196271
11MINK12.54061588
12CASK2.46735257
13MAP4K22.32599360
14TNIK2.27053656
15GRK12.05569689
16MAP2K42.01017720
17BMPR1B1.86574038
18ARAF1.80253757
19PAK61.79203011
20MAPK131.69493187
21NTRK11.65949939
22KSR21.55085994
23INSRR1.51455875
24FGFR21.46900780
25GRK51.45386427
26FES1.44427012
27PLK21.43557644
28CDK51.42789612
29ACVR1B1.38825689
30KSR11.37533748
31SIK21.35487783
32UHMK11.33765204
33STK38L1.30988836
34NUAK11.29847041
35DAPK21.28298702
36ZAK1.27229784
37MAP3K131.26041344
38CAMK2A1.22957760
39PRKCG1.22735965
40TAOK31.21986009
41RIPK41.21136775
42CSNK1G11.12459148
43PHKG21.12253491
44PHKG11.12253491
45TNK21.11836839
46MST41.11203940
47DYRK21.10643217
48MKNK21.09982187
49CDK191.09129429
50PLK41.07816134
51CAMK2B1.05918683
52GRK71.05337975
53BRSK21.04934494
54PAK31.04144550
55PRPF4B1.01925094
56CSNK1G21.00055307
57CAMKK10.99577670
58DAPK10.94517334
59OXSR10.93345549
60STK30.91640008
61STK380.91412146
62PRKD30.90864386
63CSNK1A1L0.89779416
64TYRO30.88870314
65WEE10.86922636
66STK160.86017843
67NME10.85475932
68CDK140.85181817
69SGK2230.84269931
70SGK4940.84269931
71CDK180.84040371
72ERBB30.83738240
73TRIM280.83645964
74LATS20.83302610
75ADRBK20.83082338
76WNK30.82704912
77MAPK150.82100704
78CDK150.81971582
79NLK0.81124411
80CAMK2D0.77135430
81DYRK1A0.76823783
82MAP3K20.75235053
83CAMK1G0.74783048
84CDC70.73164794
85CAMKK20.72172013
86CAMK10.71396210
87MAPKAPK50.71367908
88STK390.71026282
89CDK11A0.71024868
90TLK10.69981533
91FGR0.69310628
92STK110.69216796
93AKT30.68721872
94BCR0.68090891
95FER0.67483296
96PLK30.65712837
97RAF10.64417680
98CAMK2G0.63790951
99PRKCH0.63773128
100MAP2K60.63474289
101SGK10.63259450
102CSNK1G30.62507022
103SGK20.62062233
104PTK2B0.61582906
105MARK20.61159299
106EPHA30.59854534
107PRKCE0.59814537
108BRAF0.58998659
109LMTK20.58687405
110CDK30.56487410
111BMPR20.56365764
112RET0.55603868
113EIF2AK30.53771401
114MKNK10.53493554
115PRKACB0.53484970
116WNK40.51651724
117ADRBK10.51501703
118MAP3K10.51487164
119CCNB10.49594509
120NEK60.48435324
121VRK10.47406091
122RPS6KA30.46783351
123CSNK1A10.46377399
124CDC42BPA0.45937005
125PKN10.45551936
126MUSK0.45458631
127IRAK20.45154427
128CSNK1D0.44819059
129WNK10.44572857
130PRKCZ0.44369668
131MAPK100.44181200
132TAF10.43366430
133PRKAA10.43081869
134FYN0.39932731
135PRKACA0.39656518
136PRKG10.39555823
137PLK10.37923295
138ROCK20.37711490
139CSNK1E0.37235900
140PINK10.37058441
141ATM0.36456582
142PRKCB0.35184104
143PRKCA0.31005804
144PIK3CA0.30718053

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.59986026
2Synaptic vesicle cycle_Homo sapiens_hsa047213.32873622
3GABAergic synapse_Homo sapiens_hsa047273.10878238
4Maturity onset diabetes of the young_Homo sapiens_hsa049503.09986812
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.91488713
6Morphine addiction_Homo sapiens_hsa050322.65043505
7Circadian entrainment_Homo sapiens_hsa047132.60865997
8Protein export_Homo sapiens_hsa030602.59662708
9Olfactory transduction_Homo sapiens_hsa047402.57021790
10Glutamatergic synapse_Homo sapiens_hsa047242.51894160
11Amphetamine addiction_Homo sapiens_hsa050312.48864590
12Long-term potentiation_Homo sapiens_hsa047202.45629664
13Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.24110636
14Dopaminergic synapse_Homo sapiens_hsa047282.18889715
15Taste transduction_Homo sapiens_hsa047422.14512416
16Serotonergic synapse_Homo sapiens_hsa047262.09336378
17Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.06490880
18Collecting duct acid secretion_Homo sapiens_hsa049662.05385056
19Salivary secretion_Homo sapiens_hsa049702.00109906
20Cocaine addiction_Homo sapiens_hsa050301.99759680
21Insulin secretion_Homo sapiens_hsa049111.93776392
22Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.84097979
23Renin secretion_Homo sapiens_hsa049241.82762180
24Long-term depression_Homo sapiens_hsa047301.79464460
25Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.78405908
26Cholinergic synapse_Homo sapiens_hsa047251.75450063
27Gastric acid secretion_Homo sapiens_hsa049711.69946308
28Oxidative phosphorylation_Homo sapiens_hsa001901.69402148
29Aldosterone synthesis and secretion_Homo sapiens_hsa049251.58019850
30Calcium signaling pathway_Homo sapiens_hsa040201.57529438
31Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.53842485
32Sulfur metabolism_Homo sapiens_hsa009201.52205024
33Cardiac muscle contraction_Homo sapiens_hsa042601.52136076
34Oxytocin signaling pathway_Homo sapiens_hsa049211.49883522
35Regulation of autophagy_Homo sapiens_hsa041401.48997123
36Linoleic acid metabolism_Homo sapiens_hsa005911.45417544
37Nitrogen metabolism_Homo sapiens_hsa009101.43869992
38Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.43339583
39Vibrio cholerae infection_Homo sapiens_hsa051101.39383411
40Parkinsons disease_Homo sapiens_hsa050121.36079830
41Phototransduction_Homo sapiens_hsa047441.33792026
42Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.33172692
43Alzheimers disease_Homo sapiens_hsa050101.32649282
44GnRH signaling pathway_Homo sapiens_hsa049121.32419237
45Ether lipid metabolism_Homo sapiens_hsa005651.28006556
46Selenocompound metabolism_Homo sapiens_hsa004501.27125982
47Gap junction_Homo sapiens_hsa045401.25601367
48Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.25266690
49Fanconi anemia pathway_Homo sapiens_hsa034601.25245600
50alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.23102139
51Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.20908583
52Basal transcription factors_Homo sapiens_hsa030221.19088731
53Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.18306277
54cAMP signaling pathway_Homo sapiens_hsa040241.14768113
55Propanoate metabolism_Homo sapiens_hsa006401.12085473
56Homologous recombination_Homo sapiens_hsa034401.11466432
57Axon guidance_Homo sapiens_hsa043601.10402672
58Estrogen signaling pathway_Homo sapiens_hsa049151.10313150
59Tryptophan metabolism_Homo sapiens_hsa003801.04245271
60Huntingtons disease_Homo sapiens_hsa050161.01406711
61Melanogenesis_Homo sapiens_hsa049160.97099362
62Type II diabetes mellitus_Homo sapiens_hsa049300.95522207
63RNA polymerase_Homo sapiens_hsa030200.94846092
64Non-homologous end-joining_Homo sapiens_hsa034500.93432880
65ABC transporters_Homo sapiens_hsa020100.93269427
66Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.92399917
67Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.92304427
68Vascular smooth muscle contraction_Homo sapiens_hsa042700.88318282
69Phosphatidylinositol signaling system_Homo sapiens_hsa040700.88070942
70Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.87787761
71Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.86164800
72Dorso-ventral axis formation_Homo sapiens_hsa043200.85684066
73cGMP-PKG signaling pathway_Homo sapiens_hsa040220.82948957
74ErbB signaling pathway_Homo sapiens_hsa040120.81409102
75RNA degradation_Homo sapiens_hsa030180.81040444
76Oocyte meiosis_Homo sapiens_hsa041140.80581007
77Folate biosynthesis_Homo sapiens_hsa007900.79696312
78Peroxisome_Homo sapiens_hsa041460.77519073
79Thyroid hormone synthesis_Homo sapiens_hsa049180.74693840
80Mineral absorption_Homo sapiens_hsa049780.74639400
81Pancreatic secretion_Homo sapiens_hsa049720.74174804
82Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.73571623
83Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.72949166
84Type I diabetes mellitus_Homo sapiens_hsa049400.70409541
85Glioma_Homo sapiens_hsa052140.69844643
86Dilated cardiomyopathy_Homo sapiens_hsa054140.68193279
87Alcoholism_Homo sapiens_hsa050340.65701939
88MAPK signaling pathway_Homo sapiens_hsa040100.63989979
89Phospholipase D signaling pathway_Homo sapiens_hsa040720.63769525
90Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.62103314
91Vitamin B6 metabolism_Homo sapiens_hsa007500.61573019
92Purine metabolism_Homo sapiens_hsa002300.61370857
93Prion diseases_Homo sapiens_hsa050200.59923970
94Primary bile acid biosynthesis_Homo sapiens_hsa001200.59433449
95Steroid hormone biosynthesis_Homo sapiens_hsa001400.56655819
96Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.55330130
97beta-Alanine metabolism_Homo sapiens_hsa004100.54783003
98Choline metabolism in cancer_Homo sapiens_hsa052310.53959539
99Glucagon signaling pathway_Homo sapiens_hsa049220.53957175
100Chemical carcinogenesis_Homo sapiens_hsa052040.53701144
101Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.52725458
102Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.48979219
103Ras signaling pathway_Homo sapiens_hsa040140.46987454
104Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.46733477
105Retinol metabolism_Homo sapiens_hsa008300.46283050
106Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.45562124
107Arachidonic acid metabolism_Homo sapiens_hsa005900.44921135
108Ovarian steroidogenesis_Homo sapiens_hsa049130.44796546
109Metabolic pathways_Homo sapiens_hsa011000.44474790
110Rheumatoid arthritis_Homo sapiens_hsa053230.44173107
111Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.43553132
112Fatty acid elongation_Homo sapiens_hsa000620.43040534
113Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.41662658
114Caffeine metabolism_Homo sapiens_hsa002320.40949645
115Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.40221756
116Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.39596083
117Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.38974688
118SNARE interactions in vesicular transport_Homo sapiens_hsa041300.37786985
119Wnt signaling pathway_Homo sapiens_hsa043100.37552626
120Inositol phosphate metabolism_Homo sapiens_hsa005620.36734070
121Glycerolipid metabolism_Homo sapiens_hsa005610.35455895
122Neurotrophin signaling pathway_Homo sapiens_hsa047220.34972182
123Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.34958158
124Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.34826708
125Bile secretion_Homo sapiens_hsa049760.33080585
126Renal cell carcinoma_Homo sapiens_hsa052110.32777752
127Carbohydrate digestion and absorption_Homo sapiens_hsa049730.32332848
128Glycerophospholipid metabolism_Homo sapiens_hsa005640.31676174
129Circadian rhythm_Homo sapiens_hsa047100.31238490
130Sphingolipid signaling pathway_Homo sapiens_hsa040710.30873588
131Fat digestion and absorption_Homo sapiens_hsa049750.30694653
132Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.29831864
133Insulin signaling pathway_Homo sapiens_hsa049100.28074437
134Hedgehog signaling pathway_Homo sapiens_hsa043400.27293675
135Rap1 signaling pathway_Homo sapiens_hsa040150.27272223
136African trypanosomiasis_Homo sapiens_hsa051430.26971795
137Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.26797906
138VEGF signaling pathway_Homo sapiens_hsa043700.23932983
139Phagosome_Homo sapiens_hsa041450.23361699
140Thyroid hormone signaling pathway_Homo sapiens_hsa049190.23124886
141Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.22673942
142Butanoate metabolism_Homo sapiens_hsa006500.21860552
143Endocytosis_Homo sapiens_hsa041440.19990094

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