AHCY

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: S-adenosylhomocysteine hydrolase belongs to the adenosylhomocysteinase family. It catalyzes the reversible hydrolysis of S-adenosylhomocysteine (AdoHcy) to adenosine (Ado) and L-homocysteine (Hcy). Thus, it regulates the intracellular S-adenosylhomocysteine (SAH) concentration thought to be important for transmethylation reactions. Deficiency in this protein is one of the different causes of hypermethioninemia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.63191085
2L-phenylalanine catabolic process (GO:0006559)7.63191085
3L-phenylalanine metabolic process (GO:0006558)7.41590202
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.41590202
5aromatic amino acid family catabolic process (GO:0009074)6.89278660
6indole-containing compound catabolic process (GO:0042436)6.22178029
7indolalkylamine catabolic process (GO:0046218)6.22178029
8tryptophan catabolic process (GO:0006569)6.22178029
9kynurenine metabolic process (GO:0070189)6.10474203
10triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.01179895
11tryptophan metabolic process (GO:0006568)5.86919903
12glyoxylate metabolic process (GO:0046487)5.86628327
13bile acid biosynthetic process (GO:0006699)5.79494501
14cysteine metabolic process (GO:0006534)5.78381339
15urea metabolic process (GO:0019627)5.75696890
16urea cycle (GO:0000050)5.75696890
17sulfur amino acid catabolic process (GO:0000098)5.47990954
18serine family amino acid catabolic process (GO:0009071)5.41875058
19alpha-linolenic acid metabolic process (GO:0036109)5.33289258
20negative regulation of fibrinolysis (GO:0051918)5.31552014
21high-density lipoprotein particle remodeling (GO:0034375)5.30363658
22nitrogen cycle metabolic process (GO:0071941)5.29903146
23DNA unwinding involved in DNA replication (GO:0006268)5.13666592
24lysine metabolic process (GO:0006553)5.08249218
25lysine catabolic process (GO:0006554)5.08249218
26aromatic amino acid family metabolic process (GO:0009072)5.06968973
27glycine metabolic process (GO:0006544)5.04869378
28regulation of fibrinolysis (GO:0051917)5.04157766
29peptidyl-glutamic acid carboxylation (GO:0017187)5.01431308
30protein carboxylation (GO:0018214)5.01431308
31bile acid metabolic process (GO:0008206)4.93034785
32complement activation, alternative pathway (GO:0006957)4.92321978
33regulation of protein activation cascade (GO:2000257)4.90959241
34tyrosine metabolic process (GO:0006570)4.80089710
35fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.76453761
36amino-acid betaine metabolic process (GO:0006577)4.76301655
37* alpha-amino acid catabolic process (GO:1901606)4.74580210
38serine family amino acid metabolic process (GO:0009069)4.74001872
39serine family amino acid biosynthetic process (GO:0009070)4.73938888
40regulation of triglyceride catabolic process (GO:0010896)4.67649790
41regulation of cholesterol esterification (GO:0010872)4.67208927
42regulation of translational fidelity (GO:0006450)4.62919303
43* homocysteine metabolic process (GO:0050667)4.60942196
44regulation of complement activation (GO:0030449)4.58363495
45plasma lipoprotein particle remodeling (GO:0034369)4.54184045
46protein-lipid complex remodeling (GO:0034368)4.54184045
47macromolecular complex remodeling (GO:0034367)4.54184045
48negative regulation of cholesterol transport (GO:0032375)4.53767307
49negative regulation of sterol transport (GO:0032372)4.53767307
50reverse cholesterol transport (GO:0043691)4.53221517
51formation of translation preinitiation complex (GO:0001731)4.50739477
52DNA strand elongation involved in DNA replication (GO:0006271)4.45075859
53nuclear pore complex assembly (GO:0051292)4.42760214
54mitotic chromosome condensation (GO:0007076)4.42475266
55imidazole-containing compound metabolic process (GO:0052803)4.41275517
56indolalkylamine metabolic process (GO:0006586)4.37821954
57proline biosynthetic process (GO:0006561)4.37766011
58triglyceride homeostasis (GO:0070328)4.36885756
59acylglycerol homeostasis (GO:0055090)4.36885756
60* cellular amino acid catabolic process (GO:0009063)4.36874841
61glutamate metabolic process (GO:0006536)4.31573818
62DNA strand elongation (GO:0022616)4.31054184
63coenzyme catabolic process (GO:0009109)4.28883379
64cellular biogenic amine catabolic process (GO:0042402)4.27385176
65amine catabolic process (GO:0009310)4.27385176
66phospholipid efflux (GO:0033700)4.25861684
67bile acid and bile salt transport (GO:0015721)4.22959404
68cellular ketone body metabolic process (GO:0046950)4.20338738
69benzene-containing compound metabolic process (GO:0042537)4.17118921
70aldehyde catabolic process (GO:0046185)4.10670464
71plasma lipoprotein particle clearance (GO:0034381)4.09466578
72establishment of integrated proviral latency (GO:0075713)4.08628095
73arginine metabolic process (GO:0006525)4.04240439
74cellular glucuronidation (GO:0052695)4.00047145
75ethanol oxidation (GO:0006069)3.99699847
76dicarboxylic acid biosynthetic process (GO:0043650)3.95538544
77nuclear pore organization (GO:0006999)3.94780599
78ribosomal small subunit biogenesis (GO:0042274)3.93778618
79* cellular modified amino acid catabolic process (GO:0042219)3.93079161
80drug catabolic process (GO:0042737)3.91779573
81telomere maintenance via semi-conservative replication (GO:0032201)3.84616380
82plasma lipoprotein particle assembly (GO:0034377)3.84359248
83cholesterol efflux (GO:0033344)3.82778939
84* organic acid catabolic process (GO:0016054)3.78858247
85* carboxylic acid catabolic process (GO:0046395)3.78858247
86aspartate family amino acid catabolic process (GO:0009068)3.77447315
87protein complex localization (GO:0031503)3.76295561
88low-density lipoprotein particle remodeling (GO:0034374)3.76214182
89L-serine metabolic process (GO:0006563)3.75774502
90acetyl-CoA metabolic process (GO:0006084)3.75145976
91mitotic sister chromatid segregation (GO:0000070)3.75051288
92cofactor catabolic process (GO:0051187)3.74263933
93fibrinolysis (GO:0042730)3.73224591
94heterochromatin organization (GO:0070828)3.71060543
95blood coagulation, intrinsic pathway (GO:0007597)3.70985489
962-oxoglutarate metabolic process (GO:0006103)3.69194226
97protein localization to chromosome, centromeric region (GO:0071459)3.67454972
98DNA replication initiation (GO:0006270)3.67189777
99short-chain fatty acid metabolic process (GO:0046459)3.66365031
100ketone body metabolic process (GO:1902224)3.64688708
101response to nitrosative stress (GO:0051409)3.63617739
102cholesterol homeostasis (GO:0042632)3.63055463
103urate metabolic process (GO:0046415)3.62932185
104Golgi transport vesicle coating (GO:0048200)3.62365528
105COPI coating of Golgi vesicle (GO:0048205)3.62365528
106regulation of bile acid biosynthetic process (GO:0070857)3.60774113
107NAD biosynthetic process (GO:0009435)3.59043207
108protein localization to kinetochore (GO:0034501)3.58372428
109nicotinamide nucleotide biosynthetic process (GO:0019359)3.58025231
110pyridine nucleotide biosynthetic process (GO:0019363)3.58025231
111sterol homeostasis (GO:0055092)3.57776401
112positive regulation of triglyceride lipase activity (GO:0061365)3.57770678
113positive regulation of lipoprotein lipase activity (GO:0051006)3.57770678
114drug transmembrane transport (GO:0006855)3.57434805
115mitotic metaphase plate congression (GO:0007080)3.55124789
116glucuronate metabolic process (GO:0019585)3.52742977
117uronic acid metabolic process (GO:0006063)3.52742977
118exogenous drug catabolic process (GO:0042738)3.52641975
119negative regulation of lipase activity (GO:0060192)3.51963279
120regulation of cholesterol homeostasis (GO:2000188)3.50942838
121very-low-density lipoprotein particle assembly (GO:0034379)3.50261201
122IMP biosynthetic process (GO:0006188)3.45615533
123folic acid-containing compound biosynthetic process (GO:0009396)3.44507363
124maturation of SSU-rRNA (GO:0030490)3.44050840
125ribosome assembly (GO:0042255)3.43244639
126sister chromatid segregation (GO:0000819)3.42944523
127ribosomal small subunit assembly (GO:0000028)3.36904403
128ribosomal large subunit biogenesis (GO:0042273)3.35964758
129peptidyl-arginine omega-N-methylation (GO:0035247)3.33583278
130proline metabolic process (GO:0006560)3.31073206
131cellular protein complex localization (GO:0034629)3.29764949
132nucleobase-containing small molecule interconversion (GO:0015949)3.28587307
133mitotic nuclear envelope disassembly (GO:0007077)3.25293544
134pore complex assembly (GO:0046931)3.22722841
135ribonucleoprotein complex biogenesis (GO:0022613)3.22544316
136viral transcription (GO:0019083)3.21106665
137telomere maintenance via recombination (GO:0000722)3.12871708
138translational termination (GO:0006415)3.11697843
139regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.11510165
140IMP metabolic process (GO:0046040)3.11145927
141nucleobase biosynthetic process (GO:0046112)3.09278759
142DNA replication checkpoint (GO:0000076)3.06830663
143establishment of viral latency (GO:0019043)3.06319255
144ribosome biogenesis (GO:0042254)3.02191430
145histone arginine methylation (GO:0034969)3.02016642
146purine nucleobase biosynthetic process (GO:0009113)3.01685865
147negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.99767219
148mitotic recombination (GO:0006312)2.99554939
149nuclear envelope disassembly (GO:0051081)2.99096939
150membrane disassembly (GO:0030397)2.99096939
151nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.97653450
152chromosome condensation (GO:0030261)2.93793441
153DNA duplex unwinding (GO:0032508)2.93448035
154translational initiation (GO:0006413)2.93254826
155tRNA aminoacylation for protein translation (GO:0006418)2.90935581
156translational elongation (GO:0006414)2.88868861
157regulation of translational termination (GO:0006449)2.88097226
158protein maturation by protein folding (GO:0022417)2.87304220
159SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.85645175
160NADPH regeneration (GO:0006740)2.85235307
161DNA topological change (GO:0006265)2.82070998
162regulation of mammary gland epithelial cell proliferation (GO:0033599)2.81762661
163tRNA aminoacylation (GO:0043039)2.81073941
164amino acid activation (GO:0043038)2.81073941
165metaphase plate congression (GO:0051310)2.80007317
166DNA geometric change (GO:0032392)2.79606702
167spliceosomal tri-snRNP complex assembly (GO:0000244)2.79142621
168cotranslational protein targeting to membrane (GO:0006613)2.77763320
169tetrahydrofolate metabolic process (GO:0046653)2.77642343
170protein targeting to ER (GO:0045047)2.76407617
171pentose-phosphate shunt (GO:0006098)2.76284893
172regulation of mitochondrial translation (GO:0070129)2.74823396
173peptidyl-arginine N-methylation (GO:0035246)2.73622710
174peptidyl-arginine methylation (GO:0018216)2.73622710
175rRNA transcription (GO:0009303)2.70221610
176positive regulation of chromosome segregation (GO:0051984)2.69611708
177regulation of translational elongation (GO:0006448)2.66389702
178viral mRNA export from host cell nucleus (GO:0046784)2.66181483
179mitotic sister chromatid cohesion (GO:0007064)2.66169251
180establishment of protein localization to endoplasmic reticulum (GO:0072599)2.66080859
181regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.65048674
182DNA conformation change (GO:0071103)2.64738563
183regulation of sister chromatid cohesion (GO:0007063)2.59933750
184double-strand break repair via nonhomologous end joining (GO:0006303)2.59817967
185non-recombinational repair (GO:0000726)2.59817967
186negative regulation of mRNA processing (GO:0050686)2.58603421
187protein localization to endoplasmic reticulum (GO:0070972)2.58306738
188telomere maintenance via telomere lengthening (GO:0010833)2.57136832
189pteridine-containing compound biosynthetic process (GO:0042559)2.56411255
190viral life cycle (GO:0019058)2.56049480
191regulation of mitotic spindle organization (GO:0060236)2.55844115
192folic acid metabolic process (GO:0046655)2.54278923
193negative regulation of mRNA metabolic process (GO:1903312)2.52363640
194regulation of chromosome segregation (GO:0051983)2.51982999
195regulation of spindle organization (GO:0090224)2.51378775
196DNA packaging (GO:0006323)2.49256466
197cellular protein complex disassembly (GO:0043624)2.48839348
198CENP-A containing nucleosome assembly (GO:0034080)2.47660492

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse7.85460622
2PPARA_22158963_ChIP-Seq_LIVER_Mouse6.87167290
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.47624983
4* LXR_22158963_ChIP-Seq_LIVER_Mouse5.89182907
5CEBPA_23403033_ChIP-Seq_LIVER_Mouse5.14823708
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.85043869
7* FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.69215817
8CEBPB_23403033_ChIP-Seq_LIVER_Mouse4.13883109
9FOXM1_23109430_ChIP-Seq_U2OS_Human3.67884091
10NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.46405000
11HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.30605580
12MYC_19079543_ChIP-ChIP_MESCs_Mouse2.91456556
13E2F4_17652178_ChIP-ChIP_JURKAT_Human2.56775089
14MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.35777127
15HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.32676807
16TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.13845623
17TP63_17297297_ChIP-ChIP_HaCaT_Human2.05108865
18* THAP11_20581084_ChIP-Seq_MESCs_Mouse2.04184501
19TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.00512317
20* ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.3378364
21MYCN_18555785_ChIP-Seq_MESCs_Mouse1.90705971
22POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.89878262
23E2F1_21310950_ChIP-Seq_MCF-7_Human1.87550650
24* ETS1_20019798_ChIP-Seq_JURKAT_Human1.85227253
25CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.84073181
26CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.75409392
27DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.74747392
28NANOG_18555785_ChIP-Seq_MESCs_Mouse1.73397788
29TTF2_22483619_ChIP-Seq_HELA_Human1.70733478
30CLOCK_20551151_ChIP-Seq_293T_Human1.62431878
31KLF4_18555785_ChIP-Seq_MESCs_Mouse1.62170970
32* GABP_19822575_ChIP-Seq_HepG2_Human1.61561662
33ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.57894233
34EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.56645509
35MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.52911224
36GATA1_22025678_ChIP-Seq_K562_Human1.52805523
37CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.51440733
38KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.51262881
39ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.49324497
40EST1_17652178_ChIP-ChIP_JURKAT_Human1.49058453
41GABP_17652178_ChIP-ChIP_JURKAT_Human1.46158977
42TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.45314650
43YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.38293632
44PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.33522697
45* HNF4A_19822575_ChIP-Seq_HepG2_Human1.32273566
46STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.31712570
47ESR1_15608294_ChIP-ChIP_MCF-7_Human1.30349280
48* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.29975296
49KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.29356533
50CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.27080172
51YY1_21170310_ChIP-Seq_MESCs_Mouse1.26775421
52* FOXA2_19822575_ChIP-Seq_HepG2_Human1.23852078
53HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.22022176
54FOXP3_21729870_ChIP-Seq_TREG_Human1.20338878
55RXRA_24833708_ChIP-Seq_LIVER_Mouse1.20142808
56NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.20092357
57PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.19787303
58STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.17322076
59* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.17131970
60CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.16746806
61EGR1_19374776_ChIP-ChIP_THP-1_Human1.15834681
62HTT_18923047_ChIP-ChIP_STHdh_Human1.14153784
63* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.13440717
64AR_21909140_ChIP-Seq_LNCAP_Human1.13030516
65TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.12138822
66STAT3_1855785_ChIP-Seq_MESCs_Mouse1.10840677
67ERG_20887958_ChIP-Seq_HPC-7_Mouse1.10011447
68E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.07910851
69E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.06012196
70NANOG_21062744_ChIP-ChIP_HESCs_Human1.05911679
71E2F7_22180533_ChIP-Seq_HELA_Human1.05207100
72KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.05008751
73* CHD1_26751641_Chip-Seq_LNCaP_Human1.04091083
74HOXB4_20404135_ChIP-ChIP_EML_Mouse1.03888143
75DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.03009917
76SOX17_20123909_ChIP-Seq_XEN_Mouse1.01311763
77TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.98762144
78FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.98237497
79SOX2_18555785_ChIP-Seq_MESCs_Mouse0.97522577
80ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.97138684
81SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.96492502
82VDR_21846776_ChIP-Seq_THP-1_Human0.96488863
83NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.96317160
84ZNF263_19887448_ChIP-Seq_K562_Human0.95987436
85IRF8_22096565_ChIP-ChIP_GC-B_Human0.95528648
86POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.94855414
87TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.94307161
88TBX5_21415370_ChIP-Seq_HL-1_Mouse0.94018158
89ELK3_25401928_ChIP-Seq_HUVEC_Human0.93951660
90SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.93865700
91* MYC_18555785_ChIP-Seq_MESCs_Mouse0.92907558
92SOX2_27498859_Chip-Seq_STOMACH_Mouse0.92253256
93NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.91772830
94FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.90808673
95SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.90712227
96THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.88155361
97NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.86966763
98RARA_24833708_ChIP-Seq_LIVER_Mouse0.84703230
99ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.81545846
100* GATA4_25053715_ChIP-Seq_YYC3_Human0.81157432
101ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.80887532
102IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.80489010
103* MYC_18358816_ChIP-ChIP_MESCs_Mouse0.78861017
104RARG_19884340_ChIP-ChIP_MEFs_Mouse0.72790786
105TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.72302123
106RARB_24833708_ChIP-Seq_LIVER_Mouse0.72042339
107ELF1_17652178_ChIP-ChIP_JURKAT_Human0.68902554
108* E2F1_18555785_ChIP-Seq_MESCs_Mouse0.68362684
109CREB1_15753290_ChIP-ChIP_HEK293T_Human0.67984043
110* PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.66754825
111KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.66690137
112AUTS2_25519132_ChIP-Seq_293T-REX_Human0.65650109
113KAP1_22055183_ChIP-Seq_ESCs_Mouse0.65448714
114LXR_22292898_ChIP-Seq_THP-1_Human0.65269931
115* POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.64114116
116CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.62810838
117GATA6_25053715_ChIP-Seq_YYC3_Human0.61775199
118CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.60776295
119RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.59347237
120PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.58945277
121CEBPB_22108803_ChIP-Seq_LS180_Human0.58450536
122BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.57379279
123* FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.55566416
124SRF_21415370_ChIP-Seq_HL-1_Mouse0.54945292
125* ZFX_18555785_ChIP-Seq_MESCs_Mouse0.54842037
126PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.54504520
127SALL4_18804426_ChIP-ChIP_XEN_Mouse0.54215435
128BRD4_27068464_Chip-Seq_AML-cells_Mouse0.53992205
129NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.52937916
130* MYC_19030024_ChIP-ChIP_MESCs_Mouse0.52669653
131OCT4_18692474_ChIP-Seq_MEFs_Mouse0.52314239
132* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.52238265
133PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.51130225
134JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.50969819
135GATA1_22383799_ChIP-Seq_G1ME_Mouse0.50683268
136AR_20517297_ChIP-Seq_VCAP_Human0.50592103
137SOX2_18692474_ChIP-Seq_MEFs_Mouse0.49394804
138SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.48646576
139BCOR_27268052_Chip-Seq_Bcells_Human0.47808796
140RAD21_21589869_ChIP-Seq_MESCs_Mouse0.47563333
141P53_21459846_ChIP-Seq_SAOS-2_Human0.46750710
142IRF1_19129219_ChIP-ChIP_H3396_Human0.46210463
143TET1_21451524_ChIP-Seq_MESCs_Mouse0.45843701
144AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.45512358
145RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.45112774
146DCP1A_22483619_ChIP-Seq_HELA_Human0.44870458
147GATA2_22383799_ChIP-Seq_G1ME_Mouse0.44841211
148BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.44756632
149FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.44707889
150SRY_22984422_ChIP-ChIP_TESTIS_Rat0.44582017
151ATF3_27146783_Chip-Seq_COLON_Human0.43854756
152RACK7_27058665_Chip-Seq_MCF-7_Human0.43766934
153NELFA_20434984_ChIP-Seq_ESCs_Mouse0.43188865
154GATA1_19941827_ChIP-Seq_MEL_Mouse0.43126621
155MYC_22102868_ChIP-Seq_BL_Human0.43049450
156* KDM5A_27292631_Chip-Seq_BREAST_Human0.42086444
157XRN2_22483619_ChIP-Seq_HELA_Human0.41668350
158BCL6_27268052_Chip-Seq_Bcells_Human0.41578189

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.97813612
2MP0005360_urolithiasis7.59462303
3MP0005085_abnormal_gallbladder_physiolo6.32008747
4MP0005365_abnormal_bile_salt6.13358143
5MP0008875_abnormal_xenobiotic_pharmacok5.05394524
6MP0003806_abnormal_nucleotide_metabolis4.30413270
7MP0003693_abnormal_embryo_hatching3.98795112
8MP0003252_abnormal_bile_duct3.82751042
9MP0004957_abnormal_blastocyst_morpholog3.64051729
10MP0003111_abnormal_nucleus_morphology3.62327261
11MP0010094_abnormal_chromosome_stability3.44614371
12MP0010329_abnormal_lipoprotein_level3.38784138
13MP0009840_abnormal_foam_cell3.20762931
14MP0005083_abnormal_biliary_tract3.05248090
15MP0005332_abnormal_amino_acid2.96002941
16MP0003077_abnormal_cell_cycle2.84937520
17MP0001666_abnormal_nutrient_absorption2.76481812
18MP0003195_calcinosis2.70673509
19MP0008932_abnormal_embryonic_tissue2.70317412
20MP0010234_abnormal_vibrissa_follicle2.67319091
21MP0003941_abnormal_skin_development2.51621515
22MP0000537_abnormal_urethra_morphology2.35928318
23MP0001730_embryonic_growth_arrest2.33209839
24MP0000566_synostosis2.23230180
25MP0004019_abnormal_vitamin_homeostasis2.21493748
26MP0003191_abnormal_cellular_cholesterol2.21301650
27MP0010030_abnormal_orbit_morphology2.18474429
28MP0000609_abnormal_liver_physiology2.14868140
29MP0008058_abnormal_DNA_repair2.07026039
30MP0002138_abnormal_hepatobiliary_system2.01804496
31MP0003868_abnormal_feces_composition1.97218867
32MP0002118_abnormal_lipid_homeostasis1.97187795
33MP0008007_abnormal_cellular_replicative1.94996222
34MP0003123_paternal_imprinting1.93113763
35MP0000350_abnormal_cell_proliferation1.88384739
36MP0003315_abnormal_perineum_morphology1.87833589
37MP0005319_abnormal_enzyme/_coenzyme1.87239840
38MP0004233_abnormal_muscle_weight1.85249482
39MP0001764_abnormal_homeostasis1.80118770
40MP0001672_abnormal_embryogenesis/_devel1.77484176
41MP0005380_embryogenesis_phenotype1.77484176
42MP0002877_abnormal_melanocyte_morpholog1.77114446
43MP0004185_abnormal_adipocyte_glucose1.70111490
44MP0010352_gastrointestinal_tract_polyps1.69251192
45MP0008057_abnormal_DNA_replication1.68316660
46MP0005076_abnormal_cell_differentiation1.63117162
47MP0005451_abnormal_body_composition1.62860196
48MP0001697_abnormal_embryo_size1.62857948
49MP0002080_prenatal_lethality1.61636566
50MP0003984_embryonic_growth_retardation1.61581232
51MP0001849_ear_inflammation1.61133514
52MP0005501_abnormal_skin_physiology1.57012443
53MP0005584_abnormal_enzyme/coenzyme_acti1.55341749
54MP0003186_abnormal_redox_activity1.54082632
55MP0002088_abnormal_embryonic_growth/wei1.54004259
56MP0009697_abnormal_copulation1.53360733
57MP0002085_abnormal_embryonic_tissue1.49613098
58MP0003566_abnormal_cell_adhesion1.45899413
59MP0002697_abnormal_eye_size1.45501057
60MP0009643_abnormal_urine_homeostasis1.43102821
61MP0004272_abnormal_basement_membrane1.38076794
62MP0002084_abnormal_developmental_patter1.36370542
63MP0003656_abnormal_erythrocyte_physiolo1.35632876
64MP0003011_delayed_dark_adaptation1.34253148
65MP0002086_abnormal_extraembryonic_tissu1.33699501
66MP0003705_abnormal_hypodermis_morpholog1.32198890
67MP0000598_abnormal_liver_morphology1.30534043
68MP0000579_abnormal_nail_morphology1.29271801
69MP0000678_abnormal_parathyroid_gland1.26115045
70MP0004197_abnormal_fetal_growth/weight/1.20801159
71MP0001346_abnormal_lacrimal_gland1.19407044
72MP0000762_abnormal_tongue_morphology1.19272539
73MP0000313_abnormal_cell_death1.15268924
74MP0002089_abnormal_postnatal_growth/wei1.13108740
75MP0010307_abnormal_tumor_latency1.13029235
76MP0003937_abnormal_limbs/digits/tail_de1.12266933
77MP0005257_abnormal_intraocular_pressure1.08564015
78MP0005636_abnormal_mineral_homeostasis1.04919011
79MP0004858_abnormal_nervous_system1.03486833
80MP0001293_anophthalmia1.03159010
81MP0002111_abnormal_tail_morphology1.02056208
82MP0002092_abnormal_eye_morphology1.01780730
83MP0006036_abnormal_mitochondrial_physio1.00459966
84MP0009763_increased_sensitivity_to1.00055620
85MP0003786_premature_aging0.98319956
86MP0005647_abnormal_sex_gland0.97936812
87MP0003453_abnormal_keratinocyte_physiol0.97703184
88MP0003942_abnormal_urinary_system0.96633849
89MP0000467_abnormal_esophagus_morphology0.96553132
90MP0003567_abnormal_fetal_cardiomyocyte0.96433608
91MP0009764_decreased_sensitivity_to0.95741319
92MP0005220_abnormal_exocrine_pancreas0.95512984
93MP0000358_abnormal_cell_content/0.95187791
94MP0002098_abnormal_vibrissa_morphology0.94844024
95MP0000490_abnormal_crypts_of0.92858338
96MP0008469_abnormal_protein_level0.91600069
97MP0002249_abnormal_larynx_morphology0.87941709
98MP0002938_white_spotting0.87114214
99MP0009642_abnormal_blood_homeostasis0.86629596
100MP0008260_abnormal_autophagy0.86056515
101MP0005408_hypopigmentation0.85774684
102MP0009703_decreased_birth_body0.85768630
103MP0005670_abnormal_white_adipose0.85559754
104MP0003115_abnormal_respiratory_system0.84186796
105MP0005084_abnormal_gallbladder_morpholo0.82548168
106MP0001216_abnormal_epidermal_layer0.81755868
107MP0000604_amyloidosis0.81676672
108MP0003385_abnormal_body_wall0.81372187
109MP0001286_abnormal_eye_development0.81087234
110MP0005376_homeostasis/metabolism_phenot0.80526641
111MP0002396_abnormal_hematopoietic_system0.78569774
112MP0009053_abnormal_anal_canal0.78444042
113MP0009765_abnormal_xenobiotic_induced0.77536958
114MP0005384_cellular_phenotype0.77322582
115MP0000627_abnormal_mammary_gland0.76765269
116MP0002233_abnormal_nose_morphology0.75008051
117MP0010630_abnormal_cardiac_muscle0.74364953
118MP0001756_abnormal_urination0.73673561
119MP0005621_abnormal_cell_physiology0.73379169
120MP0000428_abnormal_craniofacial_morphol0.72807968
121MP0003890_abnormal_embryonic-extraembry0.71870415
122MP0000377_abnormal_hair_follicle0.71525814
123MP0005266_abnormal_metabolism0.71322802
124MP0010368_abnormal_lymphatic_system0.69460873
125MP0002078_abnormal_glucose_homeostasis0.69362576
126MP0002254_reproductive_system_inflammat0.68320581
127MP0003119_abnormal_digestive_system0.67646846
128MP0006035_abnormal_mitochondrial_morpho0.67407121
129MP0002971_abnormal_brown_adipose0.61874958
130MP0001661_extended_life_span0.61718257
131MP0005334_abnormal_fat_pad0.60348904
132MP0003718_maternal_effect0.60058465
133MP0002136_abnormal_kidney_physiology0.59667659
134MP0009672_abnormal_birth_weight0.59542176
135MP0005464_abnormal_platelet_physiology0.55631678
136MP0008873_increased_physiological_sensi0.55574518
137MP0002876_abnormal_thyroid_physiology0.55499077
138MP0003638_abnormal_response/metabolism_0.52705087
139MP0005535_abnormal_body_temperature0.49869947
140MP0000639_abnormal_adrenal_gland0.49178146
141MP0005395_other_phenotype0.47158636
142MP0003436_decreased_susceptibility_to0.45541212
143MP0005448_abnormal_energy_balance0.45054048
144MP0004130_abnormal_muscle_cell0.44033410
145MP0005666_abnormal_adipose_tissue0.43334443
146MP0002928_abnormal_bile_duct0.43221889
147MP0008872_abnormal_physiological_respon0.42186450
148MP0001853_heart_inflammation0.42066052
149MP0001845_abnormal_inflammatory_respons0.37056493
150MP0001243_abnormal_dermal_layer0.36128244
151MP0002970_abnormal_white_adipose0.35953746
152MP0003953_abnormal_hormone_level0.33670624
153MP0004264_abnormal_extraembryonic_tissu0.33339490
154MP0003329_amyloid_beta_deposits0.32802269
155MP0009379_abnormal_foot_pigmentation0.32777001
156MP0005058_abnormal_lysosome_morphology0.32050996
157MP0002135_abnormal_kidney_morphology0.31268690
158MP0002796_impaired_skin_barrier0.31005408
159MP0008874_decreased_physiological_sensi0.30922907
160MP0003690_abnormal_glial_cell0.30884100
161MP0009115_abnormal_fat_cell0.30761439
162MP0002132_abnormal_respiratory_system0.30194411
163MP0003724_increased_susceptibility_to0.29945981
164MP0005166_decreased_susceptibility_to0.29177259
165MP0001915_intracranial_hemorrhage0.28393396
166MP0005023_abnormal_wound_healing0.27204689
167MP0000249_abnormal_blood_vessel0.26761870
168MP0004782_abnormal_surfactant_physiolog0.26079680
169MP0000230_abnormal_systemic_arterial0.25894161
170MP0004043_abnormal_pH_regulation0.24949724
171MP0003300_gastrointestinal_ulcer0.24333897
172MP0005248_abnormal_Harderian_gland0.24260667
173MP0001881_abnormal_mammary_gland0.24203223
174MP0004381_abnormal_hair_follicle0.24144744
175MP0003959_abnormal_lean_body0.24129934
176MP0001765_abnormal_ion_homeostasis0.23183247
177MP0002060_abnormal_skin_morphology0.22604598

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)7.47411106
2Intrahepatic cholestasis (HP:0001406)7.01902198
3Abnormality of monocarboxylic acid metabolism (HP:0010996)6.98278344
4Deep venous thrombosis (HP:0002625)6.91429140
5Hypobetalipoproteinemia (HP:0003563)6.39630229
6Xanthomatosis (HP:0000991)6.09649487
7Prolonged partial thromboplastin time (HP:0003645)5.93944990
8Hyperlipoproteinemia (HP:0010980)5.26273017
9Hyperammonemia (HP:0001987)4.83883621
10Complement deficiency (HP:0004431)4.71943587
11Hypolipoproteinemia (HP:0010981)4.64297994
12Abnormality of pyrimidine metabolism (HP:0004353)4.48810723
13Hyperglycinemia (HP:0002154)4.46431293
14Abnormality of glutamine family amino acid metabolism (HP:0010902)4.44539154
15Joint hemorrhage (HP:0005261)4.39772784
16* Abnormality of sulfur amino acid metabolism (HP:0004339)4.35131219
17Epidermoid cyst (HP:0200040)4.33731949
18Ketosis (HP:0001946)4.33169439
19Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.22098523
20Hyperglycinuria (HP:0003108)4.19600883
21* Abnormality of aspartate family amino acid metabolism (HP:0010899)4.18483726
22Abnormality of the common coagulation pathway (HP:0010990)4.14672132
23* Abnormality of methionine metabolism (HP:0010901)4.14289063
24Abnormality of serine family amino acid metabolism (HP:0010894)4.10533285
25Abnormality of glycine metabolism (HP:0010895)4.10533285
26Fat malabsorption (HP:0002630)3.98841059
27Hypoalphalipoproteinemia (HP:0003233)3.91964901
28Hypoglycemic coma (HP:0001325)3.77142866
29Abnormality of the intrinsic pathway (HP:0010989)3.58252179
30Abnormality of fatty-acid metabolism (HP:0004359)3.51805702
31Abnormality of complement system (HP:0005339)3.50945079
32Hyperbilirubinemia (HP:0002904)3.41780887
33Hypercholesterolemia (HP:0003124)3.41299132
34Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.41051283
35Abnormality of nucleobase metabolism (HP:0010932)3.40781008
36Abnormality of glycolysis (HP:0004366)3.35987470
37Conjugated hyperbilirubinemia (HP:0002908)3.35627780
38Abnormality of serum amino acid levels (HP:0003112)3.33831883
39Chromosomal breakage induced by crosslinking agents (HP:0003221)3.33636984
40Reticulocytopenia (HP:0001896)3.26412174
41Delayed CNS myelination (HP:0002188)3.19344335
42Hepatocellular carcinoma (HP:0001402)3.11336756
43Multiple enchondromatosis (HP:0005701)3.07180664
44Steatorrhea (HP:0002570)3.05404819
45Chromsome breakage (HP:0040012)3.05195862
46Ketoacidosis (HP:0001993)3.03362079
47Metabolic acidosis (HP:0001942)2.88727964
48Gout (HP:0001997)2.87414366
49Abnormality of purine metabolism (HP:0004352)2.86766151
50Increased serum pyruvate (HP:0003542)2.85780062
51Spastic diplegia (HP:0001264)2.83997608
52Microvesicular hepatic steatosis (HP:0001414)2.81272454
53Lethargy (HP:0001254)2.81077965
54Abnormality of dicarboxylic acid metabolism (HP:0010995)2.77719700
55Dicarboxylic aciduria (HP:0003215)2.77719700
56Trismus (HP:0000211)2.76422201
57Myocardial infarction (HP:0001658)2.69647297
58Hypochromic microcytic anemia (HP:0004840)2.68085752
59Increased nuchal translucency (HP:0010880)2.67885321
60Progressive muscle weakness (HP:0003323)2.64284797
61Selective tooth agenesis (HP:0001592)2.63424741
62Spontaneous abortion (HP:0005268)2.62532867
63Hyperacusis (HP:0010780)2.61803102
64Cerebral edema (HP:0002181)2.61777625
65Skin nodule (HP:0200036)2.60336352
66Acanthocytosis (HP:0001927)2.57745797
67Vascular calcification (HP:0004934)2.47959651
68Neonatal onset (HP:0003623)2.45660827
69Irritability (HP:0000737)2.40164953
70Aplasia/Hypoplasia of the sacrum (HP:0008517)2.40116718
71Cholecystitis (HP:0001082)2.38568641
72Abnormal gallbladder physiology (HP:0012438)2.38568641
73Systemic lupus erythematosus (HP:0002725)2.37720544
74Abnormal gallbladder morphology (HP:0012437)2.36674547
75Late onset (HP:0003584)2.36547084
76Cholelithiasis (HP:0001081)2.33391114
77Malnutrition (HP:0004395)2.32436638
78Pterygium (HP:0001059)2.31299667
79Asymmetry of the thorax (HP:0001555)2.31033585
80Deviation of the thumb (HP:0009603)2.27385222
81Generalized aminoaciduria (HP:0002909)2.25030295
82Birth length less than 3rd percentile (HP:0003561)2.23930979
83Progressive external ophthalmoplegia (HP:0000590)2.20312293
84Hypoglycemic seizures (HP:0002173)2.19571568
85Proximal placement of thumb (HP:0009623)2.19143953
86Pancreatitis (HP:0001733)2.18661243
87Vomiting (HP:0002013)2.17961557
88Cardiovascular calcification (HP:0011915)2.17315288
89Mitral stenosis (HP:0001718)2.16733279
90Brushfield spots (HP:0001088)2.16392995
91Esophageal varix (HP:0002040)2.15056996
92Opisthotonus (HP:0002179)2.14550178
93Abnormal cartilage morphology (HP:0002763)2.13245959
94Alkalosis (HP:0001948)2.11711016
95Septate vagina (HP:0001153)2.11678259
96Insomnia (HP:0100785)2.11053341
97Nephroblastoma (Wilms tumor) (HP:0002667)2.10098124
98Poikilocytosis (HP:0004447)2.09227825
99Macrocytic anemia (HP:0001972)2.09000817
100Abnormality of cells of the erythroid lineage (HP:0012130)2.06957410
101Glomerulonephritis (HP:0000099)2.05742545
102Thrombophlebitis (HP:0004418)2.05690508
103Menorrhagia (HP:0000132)2.05651176
104Gingival bleeding (HP:0000225)2.05562004
105Abnormality of iron homeostasis (HP:0011031)2.05449315
106Enlarged kidneys (HP:0000105)2.05209514
107Hypoplasia of the capital femoral epiphysis (HP:0003090)2.04429600
108Proximal tubulopathy (HP:0000114)2.02436882
109Hyperuricemia (HP:0002149)2.01134984
110Increased purine levels (HP:0004368)2.01134984
111Facial cleft (HP:0002006)2.00886919
112Abnormality of reticulocytes (HP:0004312)2.00690044
113Abnormality of transition element cation homeostasis (HP:0011030)2.00493461
114Abnormality of the umbilical cord (HP:0010881)1.98546396
115Recurrent gram-negative bacterial infections (HP:0005420)1.95700326
116Abnormality of the gallbladder (HP:0005264)1.94398999
117Abnormality of the preputium (HP:0100587)1.93260837
118Rickets (HP:0002748)1.92035308
119Flat acetabular roof (HP:0003180)1.91202154
120Amyloidosis (HP:0011034)1.91180717
121Sensorimotor neuropathy (HP:0007141)1.90829161
122Breast hypoplasia (HP:0003187)1.90373285
123Nausea (HP:0002018)1.90183371
124Duplication of thumb phalanx (HP:0009942)1.89948377
125Renal duplication (HP:0000075)1.89653568
126Microglossia (HP:0000171)1.88572593
127Ragged-red muscle fibers (HP:0003200)1.88438996
128Embryonal renal neoplasm (HP:0011794)1.88384033
129Abnormal enzyme/coenzyme activity (HP:0012379)1.88103928
130Abnormal tarsal ossification (HP:0008369)1.87497020
131Elevated hepatic transaminases (HP:0002910)1.86678537
132Pili torti (HP:0003777)1.86421304
133Overlapping toe (HP:0001845)1.86394805
134Hydroxyprolinuria (HP:0003080)1.84633837
135Abnormality of proline metabolism (HP:0010907)1.84633837
136Overriding aorta (HP:0002623)1.84483361
137Abnormality of the Achilles tendon (HP:0005109)1.83242683
138Meckel diverticulum (HP:0002245)1.82382056
139Glycosuria (HP:0003076)1.82248203
140Abnormality of urine glucose concentration (HP:0011016)1.82248203
141Achilles tendon contracture (HP:0001771)1.81738112
142Renal cortical cysts (HP:0000803)1.79378181
143Abnormality of carpal bone ossification (HP:0006257)1.79157241
144Abnormal lung lobation (HP:0002101)1.77810210
145Ankyloglossia (HP:0010296)1.77688920
146Abnormality of vitamin metabolism (HP:0100508)1.77170148
147High anterior hairline (HP:0009890)1.77039247
148Absent epiphyses (HP:0010577)1.76630508
149Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.76630508
150Abnormalities of placenta or umbilical cord (HP:0001194)1.76544916
151Ulnar bowing (HP:0003031)1.76427988
152Atresia of the external auditory canal (HP:0000413)1.76120862
153Squamous cell carcinoma (HP:0002860)1.74272484
154Rough bone trabeculation (HP:0100670)1.72139819
155Advanced eruption of teeth (HP:0006288)1.72137578
156Missing ribs (HP:0000921)1.71568723
157Long palpebral fissure (HP:0000637)1.71330695
158Cortical dysplasia (HP:0002539)1.69507231
15911 pairs of ribs (HP:0000878)1.68668660
160Abnormal number of erythroid precursors (HP:0012131)1.67743513
161Horseshoe kidney (HP:0000085)1.67417815
162Abnormality of the ileum (HP:0001549)1.66930636
163Abnormality of cochlea (HP:0000375)1.66838231
164Absent radius (HP:0003974)1.66537874
165Poikiloderma (HP:0001029)1.65301841
166Back pain (HP:0003418)1.64079030
167Vaginal fistula (HP:0004320)1.64057962
168Sparse eyelashes (HP:0000653)1.63783904
169Small epiphyses (HP:0010585)1.63414996
170Right ventricular cardiomyopathy (HP:0011663)1.63410802
171Choanal atresia (HP:0000453)1.63364667
172Abnormality of the salivary glands (HP:0010286)1.62766624
173Breech presentation (HP:0001623)1.62542529
174Abnormal foot bone ossification (HP:0010675)1.61888749
175Broad distal phalanx of finger (HP:0009836)1.60327196
176Choanal stenosis (HP:0000452)1.59762117
177Premature rupture of membranes (HP:0001788)1.59751315
178Abnormality of the calcaneus (HP:0008364)1.58684238
179Secondary amenorrhea (HP:0000869)1.57044425
180Partial duplication of thumb phalanx (HP:0009944)1.56549751
181Abnormal ossification of hand bones (HP:0005921)1.51552170
182Absent forearm bone (HP:0003953)1.51227011
183Aplasia involving forearm bones (HP:0009822)1.51227011
184Abnormal hair laboratory examination (HP:0003328)1.50375319
185Preauricular skin tag (HP:0000384)1.49989060
186Premature skin wrinkling (HP:0100678)1.48816913
187Elfin facies (HP:0004428)1.46728329
188Abnormality of pain sensation (HP:0010832)1.46222976
189Impaired pain sensation (HP:0007328)1.46222976
190Embryonal neoplasm (HP:0002898)1.45804985
191Reduced antithrombin III activity (HP:0001976)1.45015841

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.37323083
2ERN14.05755120
3FGFR43.84959412
4SMG13.62047110
5SIK13.53819844
6PKN23.35778763
7VRK22.55783145
8FLT32.44417521
9ERBB42.40842133
10TAOK32.36008827
11TRIB32.32078677
12TSSK62.24770733
13SRPK12.12718676
14ICK2.10225084
15MAP3K102.00788026
16MAPK111.97633820
17CDK121.80987491
18MST1R1.77886270
19INSRR1.75388123
20PAK41.70155477
21GRK61.64918737
22MAP2K31.60836842
23PTK61.54977845
24TYK21.54206479
25EIF2AK11.54139135
26NEK91.53627535
27MAP2K41.52247230
28LATS21.48780765
29KDR1.45286344
30ABL21.41418294
31CHEK21.40365870
32LATS11.37799542
33TAF11.29610265
34CDK41.29466978
35BRSK11.27582781
36MAP3K111.27184279
37NEK11.25745006
38PIK3CG1.17425710
39CDK61.16333126
40NME21.14314708
41NME11.12653777
42PLK11.12155946
43CDK81.12153343
44JAK21.10737979
45PLK31.10596700
46BRAF1.03393032
47PASK1.02590742
48ATR0.99461867
49TBK10.99245691
50MAP3K30.98805857
51MAP4K10.98127645
52PLK40.97852638
53AURKA0.97027040
54CHEK10.96770461
55PDGFRA0.96706312
56ARAF0.96128330
57MAP3K70.95903755
58PDK20.94656070
59STK38L0.93172981
60MAPK40.90357219
61MAP2K60.89396935
62ERBB20.89332366
63FRK0.87647952
64ZAK0.85394805
65LMTK20.84848878
66ACVR1B0.84190559
67WEE10.82785476
68MKNK10.81344528
69MAP3K80.80336974
70MAP3K90.77455962
71BRSK20.76954474
72ALK0.76444611
73PRKAA20.75987294
74TAOK20.72232750
75EEF2K0.70911457
76MET0.70489761
77CSF1R0.70227393
78NEK20.65891307
79MAP2K20.65749493
80TESK20.65331588
81ILK0.64187557
82VRK10.64082769
83LRRK20.62614874
84DYRK1B0.60467560
85STK160.60438873
86MAP3K140.60060407
87CDK10.58428265
88DAPK20.57892359
89IRAK30.57554973
90PRKCZ0.56942951
91CDC70.56863440
92GSK3A0.56275039
93ZAP700.55971341
94FGFR20.55768866
95EIF2AK20.54734493
96CDK20.54639924
97CDK90.54345633
98TGFBR10.53854504
99PRKD30.53810194
100CAMK1D0.53774017
101MAP3K50.53581989
102RPS6KA40.52714177
103PRKACG0.52533953
104MTOR0.52398388
105TTK0.52287989
106STK100.52216877
107ATM0.51136804
108PRKCI0.50024840
109JAK10.49098576
110KSR20.46670609
111CSK0.46107436
112CLK10.45951853
113DAPK10.45816125
114EIF2AK30.45324725
115MELK0.44025792
116TTN0.43857655
117CDK11A0.43652244
118PINK10.43553585
119BRD40.43296106
120TGFBR20.43286027
121BTK0.42805427
122MAPK120.42386938
123NTRK10.41977167
124TLK10.41395311
125SCYL20.41105624
126TESK10.40906646
127CDK150.40778392
128EPHA20.40414832
129CSNK1G10.39962095
130PIM20.39777414
131CDK180.38773089
132STK30.38687778
133PRKAA10.38549553
134PDK30.38529513
135PDK40.38529513
136PAK20.38461988
137PBK0.37996180
138CSNK1E0.37713762
139PAK10.36222560
140IRAK20.35734537
141PTK20.35336432
142STK40.34440226
143CSNK2A20.34320030
144MST40.33714313
145BUB10.33095804
146PIM10.32825403
147CAMK2G0.32591278
148BMX0.31592870
149CDK70.31468285
150TIE10.31017743
151FGFR10.30688136
152EPHB10.30336032
153CSNK2A10.29681600
154RPS6KB20.28893403
155AURKB0.27950722
156AKT20.27495524
157MAP3K60.27261506

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.30898376
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.51407658
3Nitrogen metabolism_Homo sapiens_hsa009103.45096118
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.34057189
5Arginine biosynthesis_Homo sapiens_hsa002203.08858717
6Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.72986058
7Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.71243535
8Tryptophan metabolism_Homo sapiens_hsa003802.64065782
9Ribosome_Homo sapiens_hsa030102.61093480
10Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.48272249
11Complement and coagulation cascades_Homo sapiens_hsa046102.44559868
12Fatty acid degradation_Homo sapiens_hsa000712.43090338
13Base excision repair_Homo sapiens_hsa034102.37359241
14Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.36776349
15Pentose and glucuronate interconversions_Homo sapiens_hsa000402.26829161
16Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.21790689
17Peroxisome_Homo sapiens_hsa041462.06092341
18Spliceosome_Homo sapiens_hsa030402.05841206
19Butanoate metabolism_Homo sapiens_hsa006502.00520359
20RNA transport_Homo sapiens_hsa030132.00072807
21Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.99255268
22Cell cycle_Homo sapiens_hsa041101.97102202
23Propanoate metabolism_Homo sapiens_hsa006401.92914920
24Drug metabolism - other enzymes_Homo sapiens_hsa009831.89568122
25Selenocompound metabolism_Homo sapiens_hsa004501.88891557
26Nucleotide excision repair_Homo sapiens_hsa034201.88399257
27Chemical carcinogenesis_Homo sapiens_hsa052041.84176147
282-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.81113889
29Non-homologous end-joining_Homo sapiens_hsa034501.81068480
30Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.81062143
31Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.80040272
32Histidine metabolism_Homo sapiens_hsa003401.78745582
33Steroid hormone biosynthesis_Homo sapiens_hsa001401.75246071
34PPAR signaling pathway_Homo sapiens_hsa033201.74923723
35Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.72120346
36Caffeine metabolism_Homo sapiens_hsa002321.70016781
37beta-Alanine metabolism_Homo sapiens_hsa004101.68934967
38Fatty acid metabolism_Homo sapiens_hsa012121.67507851
39Retinol metabolism_Homo sapiens_hsa008301.56212078
40Phenylalanine metabolism_Homo sapiens_hsa003601.56141025
41* Cysteine and methionine metabolism_Homo sapiens_hsa002701.53828393
42Biosynthesis of amino acids_Homo sapiens_hsa012301.52047721
43Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.51117044
44Folate biosynthesis_Homo sapiens_hsa007901.47167276
45Staphylococcus aureus infection_Homo sapiens_hsa051501.46826752
46Pyruvate metabolism_Homo sapiens_hsa006201.44135194
47Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.43647092
48Cyanoamino acid metabolism_Homo sapiens_hsa004601.36504848
49Bile secretion_Homo sapiens_hsa049761.36504259
50Homologous recombination_Homo sapiens_hsa034401.35904908
51Tyrosine metabolism_Homo sapiens_hsa003501.34898529
52Carbon metabolism_Homo sapiens_hsa012001.32839723
53RNA polymerase_Homo sapiens_hsa030201.32782432
54One carbon pool by folate_Homo sapiens_hsa006701.32636005
55mRNA surveillance pathway_Homo sapiens_hsa030151.32264513
56Starch and sucrose metabolism_Homo sapiens_hsa005001.26359252
57Sulfur metabolism_Homo sapiens_hsa009201.22869927
58Fat digestion and absorption_Homo sapiens_hsa049751.19686001
59Thyroid cancer_Homo sapiens_hsa052161.17595884
60Fatty acid elongation_Homo sapiens_hsa000621.15740834
61Sulfur relay system_Homo sapiens_hsa041221.14811376
62N-Glycan biosynthesis_Homo sapiens_hsa005101.11505084
63Steroid biosynthesis_Homo sapiens_hsa001001.09571545
64Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.05722151
65Arginine and proline metabolism_Homo sapiens_hsa003301.04561022
66ABC transporters_Homo sapiens_hsa020101.02138449
67Fanconi anemia pathway_Homo sapiens_hsa034600.96178562
68Maturity onset diabetes of the young_Homo sapiens_hsa049500.92907519
69Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.91453809
70Vitamin digestion and absorption_Homo sapiens_hsa049770.90328241
71Lysine degradation_Homo sapiens_hsa003100.88351057
72Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.87786054
73Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.87256680
74Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.86295772
75Glutathione metabolism_Homo sapiens_hsa004800.84990980
76Pentose phosphate pathway_Homo sapiens_hsa000300.84054941
77Vitamin B6 metabolism_Homo sapiens_hsa007500.77826704
78p53 signaling pathway_Homo sapiens_hsa041150.75218930
79Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.71259014
80RNA degradation_Homo sapiens_hsa030180.68382594
81Chronic myeloid leukemia_Homo sapiens_hsa052200.65311215
82Glycerolipid metabolism_Homo sapiens_hsa005610.64293503
83Basal transcription factors_Homo sapiens_hsa030220.63479791
84Adherens junction_Homo sapiens_hsa045200.62115842
85Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.55639069
86Small cell lung cancer_Homo sapiens_hsa052220.54224531
87Hippo signaling pathway_Homo sapiens_hsa043900.52823971
88MicroRNAs in cancer_Homo sapiens_hsa052060.51658425
89* Metabolic pathways_Homo sapiens_hsa011000.51556569
90Basal cell carcinoma_Homo sapiens_hsa052170.48525577
91Other glycan degradation_Homo sapiens_hsa005110.47223932
92Oocyte meiosis_Homo sapiens_hsa041140.44660875
93Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.44317094
94Viral carcinogenesis_Homo sapiens_hsa052030.41825283
95Fructose and mannose metabolism_Homo sapiens_hsa000510.41059780
96Non-small cell lung cancer_Homo sapiens_hsa052230.40059725
97Prostate cancer_Homo sapiens_hsa052150.39056583
98Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.38717998
99Huntingtons disease_Homo sapiens_hsa050160.38080314
100Endometrial cancer_Homo sapiens_hsa052130.37973251
101Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.36239742
102Tight junction_Homo sapiens_hsa045300.35751000
103Fatty acid biosynthesis_Homo sapiens_hsa000610.33627036
104Galactose metabolism_Homo sapiens_hsa000520.33572471
105Pancreatic cancer_Homo sapiens_hsa052120.32832253
106Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.32021366
107Vibrio cholerae infection_Homo sapiens_hsa051100.31359270
108Colorectal cancer_Homo sapiens_hsa052100.29331536
109Wnt signaling pathway_Homo sapiens_hsa043100.27580762
110Proteoglycans in cancer_Homo sapiens_hsa052050.27142427
111Thyroid hormone signaling pathway_Homo sapiens_hsa049190.24293893
112alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.19823506
113Linoleic acid metabolism_Homo sapiens_hsa005910.17668886
114Insulin resistance_Homo sapiens_hsa049310.16550671
115Prion diseases_Homo sapiens_hsa050200.16472961
116Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.15798944
117Adipocytokine signaling pathway_Homo sapiens_hsa049200.14850687
118Pyrimidine metabolism_Homo sapiens_hsa002400.11438725
119Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.06950869
120Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.06486573
121Glycerophospholipid metabolism_Homo sapiens_hsa005640.05377044
122Systemic lupus erythematosus_Homo sapiens_hsa053220.04301612
123Glucagon signaling pathway_Homo sapiens_hsa049220.03594623
124AMPK signaling pathway_Homo sapiens_hsa041520.00781452
125Mismatch repair_Homo sapiens_hsa03430-0.2377631
126Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.2358402
127Legionellosis_Homo sapiens_hsa05134-0.2231969
128Purine metabolism_Homo sapiens_hsa00230-0.2223476
129Protein digestion and absorption_Homo sapiens_hsa04974-0.2119042
130Regulation of autophagy_Homo sapiens_hsa04140-0.1950918
131Bladder cancer_Homo sapiens_hsa05219-0.1894412
132Hepatitis C_Homo sapiens_hsa05160-0.1852147
133Proteasome_Homo sapiens_hsa03050-0.1491413
134Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1458087
135Insulin signaling pathway_Homo sapiens_hsa04910-0.1435203
136Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1315261
137Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1029020
138Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.0900547
139DNA replication_Homo sapiens_hsa03030-0.0776294
140Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0300163
141Renin-angiotensin system_Homo sapiens_hsa04614-0.0176410

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