AGXT2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a class III pyridoxal-phosphate-dependent mitochondrial aminotransferase. It catalyzes the conversion of glyoxylate to glycine using L-alanine as the amino donor. It is an important regulator of methylarginines and is involved in the control of blood pressure in kidney. Polymorphisms in this gene affect methylarginine and beta-aminoisobutyrate metabolism, and are associated with carotid atherosclerosis. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1epoxygenase P450 pathway (GO:0019373)8.76457608
2omega-hydroxylase P450 pathway (GO:0097267)8.27371728
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.67974157
4L-phenylalanine catabolic process (GO:0006559)7.67974157
5L-phenylalanine metabolic process (GO:0006558)7.33432090
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.33432090
7aromatic amino acid family catabolic process (GO:0009074)6.96652454
8drug metabolic process (GO:0017144)6.37385649
9indole-containing compound catabolic process (GO:0042436)6.34395333
10indolalkylamine catabolic process (GO:0046218)6.34395333
11tryptophan catabolic process (GO:0006569)6.34395333
12kynurenine metabolic process (GO:0070189)6.14386545
13triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.11917026
14bile acid biosynthetic process (GO:0006699)5.99988308
15tryptophan metabolic process (GO:0006568)5.96848623
16oxidative demethylation (GO:0070989)5.88068105
17urea metabolic process (GO:0019627)5.63678871
18urea cycle (GO:0000050)5.63678871
19alpha-linolenic acid metabolic process (GO:0036109)5.60592932
20cysteine metabolic process (GO:0006534)5.53881804
21negative regulation of fibrinolysis (GO:0051918)5.45043464
22* glyoxylate metabolic process (GO:0046487)5.41277715
23sulfur amino acid catabolic process (GO:0000098)5.34328473
24high-density lipoprotein particle remodeling (GO:0034375)5.34151126
25phenylpropanoid metabolic process (GO:0009698)5.34029124
26ethanol metabolic process (GO:0006067)5.31287746
27complement activation, alternative pathway (GO:0006957)5.29385502
28regulation of protein activation cascade (GO:2000257)5.28211291
29regulation of fibrinolysis (GO:0051917)5.26593818
30peptidyl-glutamic acid carboxylation (GO:0017187)5.25949696
31protein carboxylation (GO:0018214)5.25949696
32serine family amino acid catabolic process (GO:0009071)5.22080437
33nitrogen cycle metabolic process (GO:0071941)5.19139356
34bile acid metabolic process (GO:0008206)5.09400318
35aromatic amino acid family metabolic process (GO:0009072)5.05952601
36fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)5.05781125
37regulation of plasminogen activation (GO:0010755)5.00863504
38homocysteine metabolic process (GO:0050667)4.94013272
39regulation of complement activation (GO:0030449)4.93486755
40lysine metabolic process (GO:0006553)4.91328104
41lysine catabolic process (GO:0006554)4.91328104
42tyrosine metabolic process (GO:0006570)4.82310999
43regulation of triglyceride catabolic process (GO:0010896)4.71406139
44amino-acid betaine metabolic process (GO:0006577)4.70514385
45negative regulation of blood coagulation (GO:0030195)4.67619803
46negative regulation of hemostasis (GO:1900047)4.67619803
47* alpha-amino acid catabolic process (GO:1901606)4.66954740
48regulation of cholesterol esterification (GO:0010872)4.66506615
49reverse cholesterol transport (GO:0043691)4.65884488
50plasma lipoprotein particle remodeling (GO:0034369)4.59644810
51protein-lipid complex remodeling (GO:0034368)4.59644810
52macromolecular complex remodeling (GO:0034367)4.59644810
53negative regulation of protein activation cascade (GO:2000258)4.57949741
54triglyceride homeostasis (GO:0070328)4.54282171
55acylglycerol homeostasis (GO:0055090)4.54282171
56response to mercury ion (GO:0046689)4.52355957
57flavonoid metabolic process (GO:0009812)4.50937539
58negative regulation of cholesterol transport (GO:0032375)4.50920981
59negative regulation of sterol transport (GO:0032372)4.50920981
60S-adenosylmethionine metabolic process (GO:0046500)4.50841120
61indolalkylamine metabolic process (GO:0006586)4.50034950
62cellular ketone body metabolic process (GO:0046950)4.49139861
63acute-phase response (GO:0006953)4.45441775
64coenzyme catabolic process (GO:0009109)4.42071728
65phospholipid efflux (GO:0033700)4.40656693
66alkaloid metabolic process (GO:0009820)4.40079864
67cellular biogenic amine catabolic process (GO:0042402)4.39098240
68amine catabolic process (GO:0009310)4.39098240
69regulation of humoral immune response (GO:0002920)4.38833755
70bile acid and bile salt transport (GO:0015721)4.37617178
71glutamate metabolic process (GO:0006536)4.33408751
72* cellular amino acid catabolic process (GO:0009063)4.31152862
73cellular glucuronidation (GO:0052695)4.30783653
74imidazole-containing compound metabolic process (GO:0052803)4.30351238
75negative regulation of coagulation (GO:0050819)4.25958287
76negative regulation of wound healing (GO:0061045)4.23765591
77opsonization (GO:0008228)4.23602034
78plasma lipoprotein particle clearance (GO:0034381)4.21931508
79benzene-containing compound metabolic process (GO:0042537)4.21600068
80cellular modified amino acid catabolic process (GO:0042219)4.17316417
81drug catabolic process (GO:0042737)4.16662520
82ethanol oxidation (GO:0006069)4.16405094
83* serine family amino acid metabolic process (GO:0009069)4.12565604
84hormone catabolic process (GO:0042447)4.11267566
85* glycine metabolic process (GO:0006544)4.10660433
86dicarboxylic acid biosynthetic process (GO:0043650)4.10513573
87cholesterol efflux (GO:0033344)4.07535816
88arginine metabolic process (GO:0006525)3.98923640
89positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.94752694
90intestinal cholesterol absorption (GO:0030299)3.92462139
91fibrinolysis (GO:0042730)3.91341244
92ketone body metabolic process (GO:1902224)3.88788915
93low-density lipoprotein particle remodeling (GO:0034374)3.87712518
94positive regulation of blood coagulation (GO:0030194)3.86085080
95positive regulation of hemostasis (GO:1900048)3.86085080
96glucuronate metabolic process (GO:0019585)3.85479734
97uronic acid metabolic process (GO:0006063)3.85479734
98plasma lipoprotein particle assembly (GO:0034377)3.85348254
99acetyl-CoA metabolic process (GO:0006084)3.81904919
100short-chain fatty acid metabolic process (GO:0046459)3.81723976
101* carboxylic acid catabolic process (GO:0046395)3.78106255
102* organic acid catabolic process (GO:0016054)3.78106255
103fat-soluble vitamin biosynthetic process (GO:0042362)3.76670158
104urate metabolic process (GO:0046415)3.75466460
105negative regulation of complement activation (GO:0045916)3.75171156
106cofactor catabolic process (GO:0051187)3.75041873
107disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.74765214
108killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.74765214
109regulation of bile acid biosynthetic process (GO:0070857)3.74045549
110blood coagulation, intrinsic pathway (GO:0007597)3.73142118
111complement activation, classical pathway (GO:0006958)3.72919064
112drug transmembrane transport (GO:0006855)3.71237790
113regulation of cholesterol homeostasis (GO:2000188)3.69600650
114phospholipid homeostasis (GO:0055091)3.69546734
115cytolysis (GO:0019835)3.69312006
116exogenous drug catabolic process (GO:0042738)3.69242967
117complement activation (GO:0006956)3.68193055
118positive regulation of triglyceride lipase activity (GO:0061365)3.67968268
119positive regulation of lipoprotein lipase activity (GO:0051006)3.67968268
120very-low-density lipoprotein particle assembly (GO:0034379)3.67303249
121cholesterol homeostasis (GO:0042632)3.67019431
122positive regulation of lipid catabolic process (GO:0050996)3.65236786
123heme transport (GO:0015886)3.65155863
124sodium-independent organic anion transport (GO:0043252)3.64967246
125protein activation cascade (GO:0072376)3.64764657
126aspartate family amino acid catabolic process (GO:0009068)3.62322618
127sterol homeostasis (GO:0055092)3.61947239
128* serine family amino acid biosynthetic process (GO:0009070)3.61809461
129xenobiotic metabolic process (GO:0006805)3.61339778
130negative regulation of lipase activity (GO:0060192)3.59885048
131positive regulation of coagulation (GO:0050820)3.56003839
132NAD biosynthetic process (GO:0009435)3.55694303
133aminoglycoside antibiotic metabolic process (GO:0030647)3.48779769
134proline metabolic process (GO:0006560)3.48615497
135acute inflammatory response (GO:0002526)3.47570116

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse8.37598304
2PPARA_22158963_ChIP-Seq_LIVER_Mouse7.19964824
3EGR1_23403033_ChIP-Seq_LIVER_Mouse7.00395705
4LXR_22158963_ChIP-Seq_LIVER_Mouse6.49978900
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.24736524
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse5.03125781
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.78728844
8* NR1I2_20693526_ChIP-Seq_LIVER_Mouse4.02069268
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.99632903
10TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.09860997
11TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.01785589
12ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.9394879
13* HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.96879048
14FOXA2_19822575_ChIP-Seq_HepG2_Human1.61811728
15CLOCK_20551151_ChIP-Seq_293T_Human1.56315498
16HTT_18923047_ChIP-ChIP_STHdh_Human1.52278704
17* HNF4A_19822575_ChIP-Seq_HepG2_Human1.42464136
18GATA1_22025678_ChIP-Seq_K562_Human1.40878213
19MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.26573861
20THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.20941667
21STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.20092387
22TRIM28_21343339_ChIP-Seq_HEK293_Human1.18590654
23* RXRA_24833708_ChIP-Seq_LIVER_Mouse1.15980373
24STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.12169453
25ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.03545597
26CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.03512543
27IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.02810222
28HNFA_21074721_ChIP-Seq_CACO-2_Human1.01591779
29PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.99414360
30PHF8_20622853_ChIP-Seq_HELA_Human0.98668970
31ESR1_15608294_ChIP-ChIP_MCF-7_Human0.98581404
32SOX2_27498859_Chip-Seq_STOMACH_Mouse0.95503206
33TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.94807086
34NFE2_27457419_Chip-Seq_LIVER_Mouse0.88490155
35GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.88348786
36NFYA_21822215_ChIP-Seq_K562_Human0.88086633
37* BCAT_22108803_ChIP-Seq_LS180_Human0.87670098
38RARG_19884340_ChIP-ChIP_MEFs_Mouse0.87126542
39GATA6_21074721_ChIP-Seq_CACO-2_Human0.84598164
40ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.84242161
41PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.83651404
42GATA4_25053715_ChIP-Seq_YYC3_Human0.83384890
43AUTS2_25519132_ChIP-Seq_293T-REX_Human0.82961641
44FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.82801129
45IRF8_22096565_ChIP-ChIP_GC-B_Human0.82259773
46PIAS1_25552417_ChIP-Seq_VCAP_Human0.82222240
47ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.79747090
48KAP1_22055183_ChIP-Seq_ESCs_Mouse0.77509985
49TP53_18474530_ChIP-ChIP_U2OS_Human0.77415594
50BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.77112145
51SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.76335284
52SOX2_21211035_ChIP-Seq_LN229_Human0.74156397
53SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.73496495
54Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.73283364
55EZH2_27294783_Chip-Seq_NPCs_Mouse0.72246579
56ESR2_21235772_ChIP-Seq_MCF-7_Human0.71943340
57RARA_24833708_ChIP-Seq_LIVER_Mouse0.71903046
58CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.71398383
59ETV2_25802403_ChIP-Seq_MESCs_Mouse0.71221889
60ER_23166858_ChIP-Seq_MCF-7_Human0.70974165
61ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.70429103
62AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.70424896
63CBX2_22325352_ChIP-Seq_293T-Rex_Human0.68950509
64SALL4_18804426_ChIP-ChIP_XEN_Mouse0.68637266
65ETV1_20927104_ChIP-Seq_GIST48_Human0.68246985
66PCGF2_27294783_Chip-Seq_NPCs_Mouse0.67808578
67NRF2_20460467_ChIP-Seq_MEFs_Mouse0.67248574
68NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.67248574
69SUZ12_27294783_Chip-Seq_NPCs_Mouse0.67200190
70SOX2_20726797_ChIP-Seq_SW620_Human0.66824824
71ZNF263_19887448_ChIP-Seq_K562_Human0.65719297
72RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.65154924
73TCF4_18268006_ChIP-ChIP_LS174T_Human0.64166272
74EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.63672737
75NFYB_21822215_ChIP-Seq_K562_Human0.63443033
76RARB_24833708_ChIP-Seq_LIVER_Mouse0.61956203
77NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.61931207
78RAD21_21589869_ChIP-Seq_MESCs_Mouse0.61640774
79CRX_20693478_ChIP-Seq_RETINA_Mouse0.61324692
80BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.60407908
81NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.60089715
82RAC3_21632823_ChIP-Seq_H3396_Human0.59454206
83PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.59392256
84CEBPB_22108803_ChIP-Seq_LS180_Human0.58086651
85* POU3F2_20337985_ChIP-ChIP_501MEL_Human0.57507162
86MYC_19829295_ChIP-Seq_ESCs_Human0.57254006
87GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.56666194
88ESR1_21235772_ChIP-Seq_MCF-7_Human0.56564177
89E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.56097346
90IGF1R_20145208_ChIP-Seq_DFB_Human0.56016100
91KLF5_20875108_ChIP-Seq_MESCs_Mouse0.55136503
92SRY_22984422_ChIP-ChIP_TESTIS_Rat0.54743018
93CDX2_19796622_ChIP-Seq_MESCs_Mouse0.54508090
94ERG_20517297_ChIP-Seq_VCAP_Human0.53955563
95OCT4_21477851_ChIP-Seq_ESCs_Mouse0.53934216
96RBPJ_21746931_ChIP-Seq_IB4_Human0.53601910
97STAT3_1855785_ChIP-Seq_MESCs_Mouse0.53515532
98FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.53496734
99FOXA1_25552417_ChIP-Seq_VCAP_Human0.53454143
100LXR_22292898_ChIP-Seq_THP-1_Human0.53429376
101AR_20517297_ChIP-Seq_VCAP_Human0.53407972
102MYC_19915707_ChIP-ChIP_AK7_Human0.52674894
103CTCF_27219007_Chip-Seq_Bcells_Human0.52195233
104OCT4_18555785_Chip-Seq_ESCs_Mouse0.52131008
105PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.51916700
106SMAD1_18555785_Chip-Seq_ESCs_Mouse0.51331947
107ESRRB_18555785_Chip-Seq_ESCs_Mouse0.51248816
108ESET_19884257_ChIP-Seq_ESCs_Mouse0.50166556
109CDX2_20551321_ChIP-Seq_CACO-2_Human0.50025119
110FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.49987732
111CBP_21632823_ChIP-Seq_H3396_Human0.49922648
112STAT1_17558387_ChIP-Seq_HELA_Human0.48806859
113TAF15_26573619_Chip-Seq_HEK293_Human0.47749630
114NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.46641686
115PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.46452600
116P53_21459846_ChIP-Seq_SAOS-2_Human0.45641483
117FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.45331582
118FOXO3_23340844_ChIP-Seq_DLD1_Human0.45031503
119FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.43305463
120PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.42342394
121TAF2_19829295_ChIP-Seq_ESCs_Human0.42286479
122CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.41782006
123GATA1_19941827_ChIP-Seq_MEL_Mouse0.41445715
124GATA6_25053715_ChIP-Seq_YYC3_Human0.41419613
125PPAR_26484153_Chip-Seq_NCI-H1993_Human0.41289626
126GATA1_19941826_ChIP-Seq_K562_Human0.40999538
127* PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.40372077
128SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.40107966
129GATA2_19941826_ChIP-Seq_K562_Human0.40033930
130ESR1_20079471_ChIP-ChIP_T-47D_Human0.39215090
131ERG_21242973_ChIP-ChIP_JURKAT_Human0.38774102
132GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.38559122
133STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.38474853
134SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.37460133
135MYC_27129775_Chip-Seq_CORNEA_Mouse0.36785168
136LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.35838156
137CDX2_22108803_ChIP-Seq_LS180_Human0.35575370
138NCOR_22424771_ChIP-Seq_293T_Human0.35279500
139* EGR1_19032775_ChIP-ChIP_M12_Human0.34934693
140CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.34435410
141EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.34265195
142IRF1_19129219_ChIP-ChIP_H3396_Human0.33923360
143SPI1_26923725_Chip-Seq_HPCs_Mouse0.33859269

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.31733722
2MP0005360_urolithiasis7.68330979
3MP0005085_abnormal_gallbladder_physiolo6.40933467
4MP0005365_abnormal_bile_salt6.11696847
5MP0008875_abnormal_xenobiotic_pharmacok5.14226264
6MP0003806_abnormal_nucleotide_metabolis4.24534547
7MP0003252_abnormal_bile_duct3.97564403
8MP0010329_abnormal_lipoprotein_level3.49889248
9MP0009840_abnormal_foam_cell3.10943908
10MP0005083_abnormal_biliary_tract2.96342677
11MP0003195_calcinosis2.96009633
12MP0005332_abnormal_amino_acid2.90569237
13MP0001666_abnormal_nutrient_absorption2.58311450
14MP0004019_abnormal_vitamin_homeostasis2.30031318
15MP0003191_abnormal_cellular_cholesterol2.23205409
16MP0000609_abnormal_liver_physiology2.13619063
17MP0002138_abnormal_hepatobiliary_system2.10138192
18MP0002118_abnormal_lipid_homeostasis2.08227035
19MP0003868_abnormal_feces_composition1.87298664
20MP0005319_abnormal_enzyme/_coenzyme1.84471331
21MP0001764_abnormal_homeostasis1.66883058
22MP0005584_abnormal_enzyme/coenzyme_acti1.59356548
23MP0009697_abnormal_copulation1.51599197
24MP0005451_abnormal_body_composition1.44165515
25MP0009643_abnormal_urine_homeostasis1.37862144
26MP0003186_abnormal_redox_activity1.31068534
27MP0003011_delayed_dark_adaptation1.30823504
28MP0003656_abnormal_erythrocyte_physiolo1.20324943
29MP0000598_abnormal_liver_morphology1.16701926
30MP0005647_abnormal_sex_gland1.12620275
31MP0003705_abnormal_hypodermis_morpholog1.10152648
32MP0009764_decreased_sensitivity_to1.06692471
33MP0005636_abnormal_mineral_homeostasis1.04694777
34MP0000604_amyloidosis1.02971279
35MP0002132_abnormal_respiratory_system1.02256397
36MP0009763_increased_sensitivity_to0.98794699
37MP0002254_reproductive_system_inflammat0.96876566
38MP0010368_abnormal_lymphatic_system0.91073903
39MP0008469_abnormal_protein_level0.88521939
40MP0009642_abnormal_blood_homeostasis0.87675511
41MP0006036_abnormal_mitochondrial_physio0.85922927
42MP0005408_hypopigmentation0.85266914
43MP0003879_abnormal_hair_cell0.84843959
44MP0005670_abnormal_white_adipose0.81449269
45MP0002876_abnormal_thyroid_physiology0.81190893
46MP0005084_abnormal_gallbladder_morpholo0.80450149
47MP0005376_homeostasis/metabolism_phenot0.77964847
48MP0002078_abnormal_glucose_homeostasis0.77739916
49MP0009765_abnormal_xenobiotic_induced0.77366923
50MP0005220_abnormal_exocrine_pancreas0.74939813
51MP0005535_abnormal_body_temperature0.71553113
52MP0001756_abnormal_urination0.71347796
53MP0002971_abnormal_brown_adipose0.71275300
54MP0001661_extended_life_span0.69020533
55MP0005334_abnormal_fat_pad0.67540591
56MP0004130_abnormal_muscle_cell0.65861783
57MP0003690_abnormal_glial_cell0.64781534
58MP0001915_intracranial_hemorrhage0.64501002
59MP0005266_abnormal_metabolism0.63767004
60MP0005187_abnormal_penis_morphology0.61055676
61MP0009053_abnormal_anal_canal0.61049502
62MP0003329_amyloid_beta_deposits0.60985894
63MP0006035_abnormal_mitochondrial_morpho0.59765571
64MP0002282_abnormal_trachea_morphology0.59675129
65MP0002136_abnormal_kidney_physiology0.57083202
66MP0000639_abnormal_adrenal_gland0.55081531
67MP0002928_abnormal_bile_duct0.52222886
68MP0005448_abnormal_energy_balance0.51863416
69MP0005377_hearing/vestibular/ear_phenot0.50143540
70MP0003878_abnormal_ear_physiology0.50143540
71MP0005395_other_phenotype0.49839500
72MP0005464_abnormal_platelet_physiology0.48145374
73MP0002249_abnormal_larynx_morphology0.48066075
74MP0003638_abnormal_response/metabolism_0.47466217
75MP0008874_decreased_physiological_sensi0.44824115
76MP0004043_abnormal_pH_regulation0.44292669
77MP0002822_catalepsy0.43909048
78MP0003724_increased_susceptibility_to0.43732485
79MP0003718_maternal_effect0.43298518
80MP0008873_increased_physiological_sensi0.43046203
81MP0005023_abnormal_wound_healing0.42722084
82MP0004782_abnormal_surfactant_physiolog0.42541538
83MP0003953_abnormal_hormone_level0.41653411
84MP0003183_abnormal_peptide_metabolism0.41438797
85MP0002837_dystrophic_cardiac_calcinosis0.41423989
86MP0004381_abnormal_hair_follicle0.39448417
87MP0005666_abnormal_adipose_tissue0.38869875
88MP0003075_altered_response_to0.38609042
89MP0005166_decreased_susceptibility_to0.38482334
90MP0009785_altered_susceptibility_to0.38440423
91MP0003436_decreased_susceptibility_to0.37935515
92MP0008872_abnormal_physiological_respon0.37849001
93MP0003959_abnormal_lean_body0.37846278
94MP0005248_abnormal_Harderian_gland0.37734856
95MP0009672_abnormal_birth_weight0.36472910
96MP0000230_abnormal_systemic_arterial0.36002474
97MP0002168_other_aberrant_phenotype0.35718689
98MP0002796_impaired_skin_barrier0.34948622
99MP0000579_abnormal_nail_morphology0.34277305
100MP0009384_cardiac_valve_regurgitation0.33337682
101MP0001765_abnormal_ion_homeostasis0.31637532
102MP0006082_CNS_inflammation0.31172979
103MP0009115_abnormal_fat_cell0.31024290
104MP0005058_abnormal_lysosome_morphology0.29956079
105MP0002970_abnormal_white_adipose0.29154502
106MP0000249_abnormal_blood_vessel0.28670404
107MP0000467_abnormal_esophagus_morphology0.28430554
108MP0005164_abnormal_response_to0.27829598
109MP0001845_abnormal_inflammatory_respons0.27393670
110MP0001243_abnormal_dermal_layer0.26799594
111MP0010386_abnormal_urinary_bladder0.26655163
112MP0001853_heart_inflammation0.26561509
113MP0001881_abnormal_mammary_gland0.26327195
114MP0002135_abnormal_kidney_morphology0.25771751
115MP0004883_abnormal_blood_vessel0.25102771
116MP0004272_abnormal_basement_membrane0.23296215
117MP0001986_abnormal_taste_sensitivity0.21997333
118MP0002332_abnormal_exercise_endurance0.21595737
119MP0003633_abnormal_nervous_system0.19703280
120MP0002089_abnormal_postnatal_growth/wei0.19109106
121MP0005409_darkened_coat_color0.18758850

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)7.35978567
2Intrahepatic cholestasis (HP:0001406)7.25431978
3Deep venous thrombosis (HP:0002625)7.19526786
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.57958164
5Prolonged partial thromboplastin time (HP:0003645)6.37738839
6Hypobetalipoproteinemia (HP:0003563)6.25452105
7Xanthomatosis (HP:0000991)6.19972607
8Hyperlipoproteinemia (HP:0010980)5.39369999
9Complement deficiency (HP:0004431)5.32110917
10Joint hemorrhage (HP:0005261)4.67336181
11Hypolipoproteinemia (HP:0010981)4.63129844
12Hyperammonemia (HP:0001987)4.62547571
13Hyperglycinemia (HP:0002154)4.53672481
14Epidermoid cyst (HP:0200040)4.45451704
15Ketosis (HP:0001946)4.36964559
16Abnormality of the common coagulation pathway (HP:0010990)4.35857249
17Abnormality of glutamine family amino acid metabolism (HP:0010902)4.33280574
18Abnormality of sulfur amino acid metabolism (HP:0004339)4.26798958
19Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.24103311
20Abnormality of aspartate family amino acid metabolism (HP:0010899)4.20533430
21Abnormality of methionine metabolism (HP:0010901)4.17647377
22Hyperglycinuria (HP:0003108)4.15246854
23Fat malabsorption (HP:0002630)4.11559085
24Abnormality of serine family amino acid metabolism (HP:0010894)4.08789303
25Abnormality of glycine metabolism (HP:0010895)4.08789303
26Hypoalphalipoproteinemia (HP:0003233)4.00448198
27Hypoglycemic coma (HP:0001325)3.87892761
28Abnormality of complement system (HP:0005339)3.86492472
29Abnormality of pyrimidine metabolism (HP:0004353)3.77967848
30Conjugated hyperbilirubinemia (HP:0002908)3.71692014
31Nephritis (HP:0000123)3.68202301
32Abnormality of the intrinsic pathway (HP:0010989)3.67560440
33Hypercholesterolemia (HP:0003124)3.50963481
34Abnormality of fatty-acid metabolism (HP:0004359)3.42840217
35Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.33612917
36Hyperbilirubinemia (HP:0002904)3.30443879
37Ketoacidosis (HP:0001993)3.21572504
38Delayed CNS myelination (HP:0002188)3.20755116
39Abnormality of nucleobase metabolism (HP:0010932)3.18961628
40Abnormality of serum amino acid levels (HP:0003112)3.12857726
41Steatorrhea (HP:0002570)3.10611493
42Hepatocellular carcinoma (HP:0001402)2.98621498
43Spontaneous abortion (HP:0005268)2.96738896
44Abnormality of purine metabolism (HP:0004352)2.89458518
45Hypochromic microcytic anemia (HP:0004840)2.88877937
46Myocardial infarction (HP:0001658)2.87717703
47Gout (HP:0001997)2.85627093
48Osteomalacia (HP:0002749)2.85499258
49Metabolic acidosis (HP:0001942)2.82669641
50Skin nodule (HP:0200036)2.74818307
51Hyperphosphaturia (HP:0003109)2.73345758
52Systemic lupus erythematosus (HP:0002725)2.71287933
53Vascular calcification (HP:0004934)2.68314720
54Lethargy (HP:0001254)2.66270599
55Abnormality of dicarboxylic acid metabolism (HP:0010995)2.64525133
56Dicarboxylic aciduria (HP:0003215)2.64525133
57Increased circulating renin level (HP:0000848)2.54856533
58Fair hair (HP:0002286)2.50622841
59Hypoglycemic seizures (HP:0002173)2.50598921
60Spastic diplegia (HP:0001264)2.49936536
61Acanthocytosis (HP:0001927)2.48232039
62Cerebral edema (HP:0002181)2.42832325
63Mitral stenosis (HP:0001718)2.41971983
64Abnormal gallbladder morphology (HP:0012437)2.41066826
65Irritability (HP:0000737)2.40998258
66Neonatal onset (HP:0003623)2.39491842
67Reduced antithrombin III activity (HP:0001976)2.39056362
68Cardiovascular calcification (HP:0011915)2.37738120
69Neonatal hypoglycemia (HP:0001998)2.35647888
70Elevated alkaline phosphatase (HP:0003155)2.35345357
71Malnutrition (HP:0004395)2.35309714
72Cholelithiasis (HP:0001081)2.35120182
73Glomerulonephritis (HP:0000099)2.34697412
74Recurrent gram-negative bacterial infections (HP:0005420)2.31232803
75Abnormal urine phosphate concentration (HP:0012599)2.30730548
76Cholecystitis (HP:0001082)2.30068405
77Abnormal gallbladder physiology (HP:0012438)2.30068405
78Metabolic alkalosis (HP:0200114)2.25930010
79Generalized aminoaciduria (HP:0002909)2.25552375
80Purpura (HP:0000979)2.21827656
81Enlarged kidneys (HP:0000105)2.21748086
82Sensorimotor neuropathy (HP:0007141)2.21662154
83Late onset (HP:0003584)2.18064285
84Amyloidosis (HP:0011034)2.17521674
85Abnormality of alkaline phosphatase activity (HP:0004379)2.16974770
86Pancreatitis (HP:0001733)2.16022356
87Esophageal varix (HP:0002040)2.15701327
88Vomiting (HP:0002013)2.15278628
89Pulmonary embolism (HP:0002204)2.14690996
90Gingival bleeding (HP:0000225)2.11391089
91Alkalosis (HP:0001948)2.09999915
92Abnormality of vitamin metabolism (HP:0100508)2.09997866
93Rickets (HP:0002748)2.08728466
94Brushfield spots (HP:0001088)2.08556929
95Hypokalemic alkalosis (HP:0001949)2.06573609
96Menorrhagia (HP:0000132)2.06126644
97Thrombophlebitis (HP:0004418)2.05346032
98Hyperinsulinemic hypoglycemia (HP:0000825)2.03397712
99Opisthotonus (HP:0002179)2.02840330
100Proximal tubulopathy (HP:0000114)1.99509249
101Abnormality of proline metabolism (HP:0010907)1.98492129
102Hydroxyprolinuria (HP:0003080)1.98492129
103Abnormality of the gallbladder (HP:0005264)1.97458102
104Hyperactive renin-angiotensin system (HP:0000841)1.96716401
105Increased purine levels (HP:0004368)1.94875305
106Hyperuricemia (HP:0002149)1.94875305
107Hemorrhage of the eye (HP:0011885)1.94860155
108Poikilocytosis (HP:0004447)1.93420063
109Potter facies (HP:0002009)1.92881150
110Facial shape deformation (HP:0011334)1.92881150
111Abnormal enzyme/coenzyme activity (HP:0012379)1.92701447
112Hypophosphatemic rickets (HP:0004912)1.92590007
113Hypophosphatemia (HP:0002148)1.89035362
114Abnormal cartilage morphology (HP:0002763)1.88852434
115Renal cortical cysts (HP:0000803)1.86408337
116Impaired platelet aggregation (HP:0003540)1.85535779
117Abnormal platelet function (HP:0011869)1.85535779
118Abnormality of iron homeostasis (HP:0011031)1.85014383
119Abnormality of transition element cation homeostasis (HP:0011030)1.84967440
120Abnormality of urine glucose concentration (HP:0011016)1.83402683
121Glycosuria (HP:0003076)1.83402683
122Cerebral palsy (HP:0100021)1.74174366
123Increased serum ferritin (HP:0003281)1.73670919
124Abnormal urine output (HP:0012590)1.73180530
125Abnormality of the Achilles tendon (HP:0005109)1.70528077
126Generalized hypopigmentation of hair (HP:0011358)1.70506197
127Joint swelling (HP:0001386)1.70478405
128Hypomagnesemia (HP:0002917)1.69864978
129Arthropathy (HP:0003040)1.63209961

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.24771597
2FGFR44.59706519
3SIK14.42756393
4ERN14.34140810
5INSRR3.03679022
6TAOK33.00849519
7ERBB42.97188966
8MAP2K42.27523572
9MST1R2.16114136
10PKN22.16006423
11MAPK111.92034143
12PIK3CG1.84334302
13FLT31.83804679
14TRIB31.73309612
15LATS11.69229326
16TYK21.64506244
17PIK3CA1.52612749
18PTK61.48467658
19ABL21.47905740
20DAPK21.45453488
21FRK1.41892658
22NTRK31.40081587
23FGFR21.38839465
24NEK91.38385151
25PDK21.37750673
26ACVR1B1.34790803
27MAP3K71.24805710
28JAK21.22330741
29MAP3K121.21841469
30KDR1.21508443
31PINK11.18077872
32STK391.17899827
33STK38L1.17061109
34PRKAA21.12965842
35NLK1.10685415
36GRK61.06546748
37MAP3K141.01561742
38MAP2K31.01449749
39ERBB21.01416829
40JAK10.99304580
41TBK10.99022026
42FER0.93504586
43MAPK150.93436848
44MAPK40.93413438
45PRKCZ0.93217193
46MAP3K100.92640390
47ADRBK20.90988270
48MAP3K20.88485668
49MAP3K30.87047291
50EPHB10.86807690
51MET0.85192631
52KSR20.83026927
53PRKACA0.79788679
54TIE10.79699444
55MAPK120.76699294
56PRKACG0.75371771
57CDK60.75192916
58DYRK1B0.74275930
59GSK3A0.73145635
60SGK30.72723170
61EPHA30.71200287
62PRKAA10.70566894
63MAP3K110.69886540
64CAMK2G0.69120376
65PRKG10.68840646
66MYLK0.66563185
67CSK0.66180218
68IRAK30.66162927
69CAMK1D0.64100491
70MAP2K60.62318260
71WNK30.60754935
72FGFR30.59513993
73PTK20.59044264
74TGFBR20.58960493
75RIPK10.57841877
76SGK20.57318187
77WNK40.56708608
78MAPK70.54746093
79PRPF4B0.54165787
80PDPK10.53504265
81TNK20.52797353
82STK380.52706140
83SGK2230.52357311
84SGK4940.52357311
85CSF1R0.51622776
86PRKCB0.50422401
87IKBKE0.49358253
88PRKCQ0.49054905
89SGK10.48630569
90CSNK1G10.47038521
91PRKCE0.45566783
92EPHA40.45119033
93TXK0.45113716
94ARAF0.44278014
95IGF1R0.43243002
96PDK30.42846152
97PDK40.42846152
98BMX0.42256175
99PRKG20.41411292
100MAP3K50.41293474
101RPS6KA30.40811089
102PKN10.40283264
103GRK10.39613853
104PRKACB0.39507933
105RET0.39332992
106MUSK0.39001274
107CSNK1A10.38945845
108MAP2K10.38680330
109PRKCG0.38491147
110TAOK20.37783109
111ICK0.37735850
112MAP3K130.36266977
113SRC0.35896741
114OXSR10.34689754
115KIT0.34419352
116CDK40.34394779
117MTOR0.34254873
118ZAP700.34027092
119CAMKK10.33671522
120MAP3K60.33393531
121SCYL20.33209771
122PDK10.33105815
123EGFR0.32229139
124CSNK1D0.32172930
125CAMK40.29026639
126CDK90.28522020
127CAMKK20.27964904
128MAP3K90.27807619
129AKT30.27557931
130PBK0.27442166
131IRAK10.26962375
132IRAK20.26760158
133PRKCA0.26088443
134CSNK1G20.25821529
135CAMK1G0.24276684
136MAP3K10.24051562
137PAK30.23463587
138LATS20.21969957

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.49305702
2Nitrogen metabolism_Homo sapiens_hsa009103.54613982
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.39306576
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.38568885
5Arginine biosynthesis_Homo sapiens_hsa002203.02614024
6Tryptophan metabolism_Homo sapiens_hsa003802.73881439
7Complement and coagulation cascades_Homo sapiens_hsa046102.69219056
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.68678720
9Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.67526300
10Fatty acid degradation_Homo sapiens_hsa000712.51294136
11* Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.44040913
12* Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.35502491
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.30323990
14Butanoate metabolism_Homo sapiens_hsa006502.24289962
15Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.13172906
16Peroxisome_Homo sapiens_hsa041462.13132416
17Propanoate metabolism_Homo sapiens_hsa006402.01156334
18Chemical carcinogenesis_Homo sapiens_hsa052041.92760861
19Steroid hormone biosynthesis_Homo sapiens_hsa001401.91734657
20Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.90543809
21Histidine metabolism_Homo sapiens_hsa003401.89590551
22PPAR signaling pathway_Homo sapiens_hsa033201.85292967
23Fatty acid metabolism_Homo sapiens_hsa012121.81883106
24Drug metabolism - other enzymes_Homo sapiens_hsa009831.75196541
25Caffeine metabolism_Homo sapiens_hsa002321.74093236
26beta-Alanine metabolism_Homo sapiens_hsa004101.73834555
27Retinol metabolism_Homo sapiens_hsa008301.69473827
28Staphylococcus aureus infection_Homo sapiens_hsa051501.68680934
29Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.68427445
30Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.66238909
31Selenocompound metabolism_Homo sapiens_hsa004501.62142946
322-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.57807402
33* Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.57633933
34Phenylalanine metabolism_Homo sapiens_hsa003601.56754040
35Bile secretion_Homo sapiens_hsa049761.51649447
36Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.44472455
37Tyrosine metabolism_Homo sapiens_hsa003501.43015914
38Pyruvate metabolism_Homo sapiens_hsa006201.41918708
39Sulfur metabolism_Homo sapiens_hsa009201.37144102
40Fatty acid elongation_Homo sapiens_hsa000621.31622044
41Starch and sucrose metabolism_Homo sapiens_hsa005001.29817502
42Folate biosynthesis_Homo sapiens_hsa007901.20646476
43Biosynthesis of amino acids_Homo sapiens_hsa012301.20305696
44ABC transporters_Homo sapiens_hsa020101.19100218
45* Cysteine and methionine metabolism_Homo sapiens_hsa002701.17846512
46Steroid biosynthesis_Homo sapiens_hsa001001.16673335
47Carbon metabolism_Homo sapiens_hsa012001.15965976
48Fat digestion and absorption_Homo sapiens_hsa049751.11353464
49Cyanoamino acid metabolism_Homo sapiens_hsa004601.09260173
50Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.08275166
51Maturity onset diabetes of the young_Homo sapiens_hsa049501.03536120
52Arginine and proline metabolism_Homo sapiens_hsa003300.98909978
53Vitamin B6 metabolism_Homo sapiens_hsa007500.95525138
54Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.94929034
55Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.94580113
56Sulfur relay system_Homo sapiens_hsa041220.91148735
57Vitamin digestion and absorption_Homo sapiens_hsa049770.90478119
58Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.86098437
59Lysine degradation_Homo sapiens_hsa003100.84930738
60One carbon pool by folate_Homo sapiens_hsa006700.74448440
61Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.72609336
62Glutathione metabolism_Homo sapiens_hsa004800.70261634
63Glycerolipid metabolism_Homo sapiens_hsa005610.68734544
64Pentose phosphate pathway_Homo sapiens_hsa000300.56962491
65Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.56283504
66Fatty acid biosynthesis_Homo sapiens_hsa000610.49882183
67* Metabolic pathways_Homo sapiens_hsa011000.46405656
68Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.40312534
69Prion diseases_Homo sapiens_hsa050200.36126430
70Fructose and mannose metabolism_Homo sapiens_hsa000510.25881479
71alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.25666625
72Galactose metabolism_Homo sapiens_hsa000520.25284942
73Insulin resistance_Homo sapiens_hsa049310.22751840
74Adipocytokine signaling pathway_Homo sapiens_hsa049200.21705211
75Pertussis_Homo sapiens_hsa051330.20955947
76Linoleic acid metabolism_Homo sapiens_hsa005910.20435598
77Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.19370343
78Glycerophospholipid metabolism_Homo sapiens_hsa005640.14652619
79Mineral absorption_Homo sapiens_hsa049780.10118533
80Glucagon signaling pathway_Homo sapiens_hsa049220.09721011
81Serotonergic synapse_Homo sapiens_hsa047260.02197545
82AMPK signaling pathway_Homo sapiens_hsa041520.01711207
83Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.2419360
84Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.2397994
85Amoebiasis_Homo sapiens_hsa05146-0.2386243
86Bladder cancer_Homo sapiens_hsa05219-0.2382850
87Type II diabetes mellitus_Homo sapiens_hsa04930-0.2331824
88Vascular smooth muscle contraction_Homo sapiens_hsa04270-0.2174069
89Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.1957083
90Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1923990
91Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.1893425
92Ether lipid metabolism_Homo sapiens_hsa00565-0.1808642
93Protein digestion and absorption_Homo sapiens_hsa04974-0.1800418
94African trypanosomiasis_Homo sapiens_hsa05143-0.1737699
95Hepatitis C_Homo sapiens_hsa05160-0.1728668
96Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1674923
97Renin-angiotensin system_Homo sapiens_hsa04614-0.1632276
98Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1617617
99Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1573981
100Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1471931
101Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1319365
102Regulation of autophagy_Homo sapiens_hsa04140-0.1292307
103Insulin signaling pathway_Homo sapiens_hsa04910-0.1084241
104Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.1003054
105Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0827846
106Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0745768
107Sphingolipid metabolism_Homo sapiens_hsa00600-0.0687413
108Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0420935
109Other glycan degradation_Homo sapiens_hsa00511-0.0268136

Most similar genes based on co-expression Upload to Enrichr

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