AGRN

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes one of several proteins that are critical in the development of the neuromuscular junction (NMJ), as identified in mouse knock-out studies. The encoded protein contains several laminin G, Kazal type serine protease inhibitor, and epidermal growth factor domains. Additional post-translational modifications occur to add glycosaminoglycans and disulfide bonds. In one family with congenital myasthenic syndrome affecting limb-girdle muscles, a mutation in this gene was found. Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1desmosome organization (GO:0002934)6.14318344
2activation of Rac GTPase activity (GO:0032863)4.56040070
3branching involved in salivary gland morphogenesis (GO:0060445)4.42690836
4layer formation in cerebral cortex (GO:0021819)4.42448927
5atrioventricular valve morphogenesis (GO:0003181)4.22750909
6COPI coating of Golgi vesicle (GO:0048205)4.10618745
7Golgi transport vesicle coating (GO:0048200)4.10618745
8dichotomous subdivision of an epithelial terminal unit (GO:0060600)4.07232168
9cytoskeletal anchoring at plasma membrane (GO:0007016)3.92192656
10protein retention in ER lumen (GO:0006621)3.84727140
11semaphorin-plexin signaling pathway (GO:0071526)3.84271073
12maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.83466031
13hemidesmosome assembly (GO:0031581)3.79303148
14polarized epithelial cell differentiation (GO:0030859)3.75283236
15cell migration in hindbrain (GO:0021535)3.75037778
16apoptotic process involved in morphogenesis (GO:0060561)3.74696329
17glial cell proliferation (GO:0014009)3.74376170
18regulation of hippo signaling (GO:0035330)3.74074354
19adherens junction assembly (GO:0034333)3.73647363
20establishment of nucleus localization (GO:0040023)3.61580310
21regulation of cholesterol biosynthetic process (GO:0045540)3.57660703
22branching involved in mammary gland duct morphogenesis (GO:0060444)3.56796306
23hippo signaling (GO:0035329)3.56367195
24plasma membrane repair (GO:0001778)3.52046361
25basement membrane organization (GO:0071711)3.48904997
26regulation of glucose import in response to insulin stimulus (GO:2001273)3.47386613
27convergent extension (GO:0060026)3.40639513
28collecting duct development (GO:0072044)3.37835826
29planar cell polarity pathway involved in neural tube closure (GO:0090179)3.34806486
30cell-substrate adherens junction assembly (GO:0007045)3.33055782
31focal adhesion assembly (GO:0048041)3.33055782
32regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.29403773
33negative regulation of catenin import into nucleus (GO:0035414)3.25252032
34cell-substrate junction assembly (GO:0007044)3.24981807
35protein localization to endosome (GO:0036010)3.23782365
36endothelial cell morphogenesis (GO:0001886)3.21717434
37negative regulation of cell size (GO:0045792)3.18253135
38positive regulation of osteoblast proliferation (GO:0033690)3.14360873
39adherens junction organization (GO:0034332)3.12551997
40regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.12442343
41endothelial cell chemotaxis (GO:0035767)3.10445865
42dendritic spine morphogenesis (GO:0060997)3.09984422
43cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.08532029
44regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.04703265
45paraxial mesoderm development (GO:0048339)3.04282742
46mesodermal cell differentiation (GO:0048333)3.03365539
47retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.01769297
48positive regulation of histone deacetylation (GO:0031065)2.96935471
49establishment of apical/basal cell polarity (GO:0035089)2.96802363
50axonal fasciculation (GO:0007413)2.95457478
51regulation of early endosome to late endosome transport (GO:2000641)2.95199066
52skin morphogenesis (GO:0043589)2.95092414
53endodermal cell differentiation (GO:0035987)2.90407626
54lung epithelium development (GO:0060428)2.87723230
55regulation of axon extension involved in axon guidance (GO:0048841)2.86926150
56apical protein localization (GO:0045176)2.85263832
57cell migration involved in sprouting angiogenesis (GO:0002042)2.84246241
58axon extension involved in axon guidance (GO:0048846)2.82697369
59neuron projection extension involved in neuron projection guidance (GO:1902284)2.82697369
60establishment or maintenance of monopolar cell polarity (GO:0061339)2.80188183
61establishment of monopolar cell polarity (GO:0061162)2.80188183
62locomotory exploration behavior (GO:0035641)2.80177807
63embryonic foregut morphogenesis (GO:0048617)2.78957179
64lateral sprouting from an epithelium (GO:0060601)2.78097257
65negative regulation of chondrocyte differentiation (GO:0032331)2.78023929
66regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.78014216
67establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.76709380
68mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.76444484
69bone remodeling (GO:0046849)2.76363852
70regulation of apoptotic process involved in morphogenesis (GO:1902337)2.75694606
71neural tube development (GO:0021915)2.75149911
72regulation of endothelial cell chemotaxis (GO:2001026)2.75016102
73vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.74895186
74neuron recognition (GO:0008038)2.74600464
75negative regulation of fatty acid transport (GO:2000192)2.74440085
76ephrin receptor signaling pathway (GO:0048013)2.74203467
77establishment of planar polarity (GO:0001736)2.73705749
78establishment of tissue polarity (GO:0007164)2.73705749
79endothelial cell differentiation (GO:0045446)2.73601972
80insulin-like growth factor receptor signaling pathway (GO:0048009)2.71773454
81cell communication by electrical coupling (GO:0010644)2.69583698
82dendrite morphogenesis (GO:0048813)2.69367208
83regulation of cholesterol homeostasis (GO:2000188)2.67620902
84positive regulation of Cdc42 GTPase activity (GO:0043089)2.67434744
85lung-associated mesenchyme development (GO:0060484)2.66562946
86gastrulation with mouth forming second (GO:0001702)2.66152065
87positive regulation of receptor recycling (GO:0001921)2.66005511
88regulation of axon guidance (GO:1902667)2.65380975
89glucose catabolic process (GO:0006007)2.64860419
90lymphangiogenesis (GO:0001946)2.64796467
91vocalization behavior (GO:0071625)2.64416112
92apoptotic process involved in development (GO:1902742)2.64023782
93cochlea morphogenesis (GO:0090103)2.63867086
94proline biosynthetic process (GO:0006561)2.63630062
95axon extension (GO:0048675)2.63615231
96vascular endothelial growth factor signaling pathway (GO:0038084)2.60568370
97negative regulation of axon extension involved in axon guidance (GO:0048843)2.59104530
98maternal placenta development (GO:0001893)2.57701444
99renal filtration (GO:0097205)2.57519644
100regulation of water loss via skin (GO:0033561)2.56403488
101regulation of extracellular matrix disassembly (GO:0010715)2.55627222
102cell-cell junction maintenance (GO:0045217)2.55404812
103gap junction assembly (GO:0016264)2.55150750
104regulation of mammary gland epithelial cell proliferation (GO:0033599)2.54932750
105embryonic retina morphogenesis in camera-type eye (GO:0060059)2.54844725
106peptidyl-tyrosine autophosphorylation (GO:0038083)2.54828610
107positive regulation of synapse maturation (GO:0090129)2.54024141
108L-serine transport (GO:0015825)2.53292090
109ear development (GO:0043583)2.52797005
110cell junction assembly (GO:0034329)2.52698338
111embryonic eye morphogenesis (GO:0048048)2.50796098
112cell junction maintenance (GO:0034331)2.50275647
113surfactant homeostasis (GO:0043129)2.50167735
114morphogenesis of embryonic epithelium (GO:0016331)2.49423625
115receptor catabolic process (GO:0032801)2.47080493
116heart valve morphogenesis (GO:0003179)2.45298891
117regulation of establishment of planar polarity (GO:0090175)2.44911955
118synaptic vesicle maturation (GO:0016188)2.44763127
119cell communication involved in cardiac conduction (GO:0086065)2.44366032
120Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.44263931
121positive regulation of establishment of protein localization to plasma membrane (GO:0090004)2.44242806
122eye morphogenesis (GO:0048592)2.43388675
123cell junction organization (GO:0034330)2.42847593
124proximal/distal pattern formation (GO:0009954)2.42786899
125positive regulation of blood vessel endothelial cell migration (GO:0043536)2.42694494
126camera-type eye morphogenesis (GO:0048593)2.42494730
127blood vessel endothelial cell migration (GO:0043534)2.40539019
128sequestering of extracellular ligand from receptor (GO:0035581)2.38309930
129cell adhesion mediated by integrin (GO:0033627)2.37932144
130negative regulation of cell fate specification (GO:0009996)2.37778055
131regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.37599486
132cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.37203790
133dorsal/ventral axis specification (GO:0009950)2.36987091
134non-canonical Wnt signaling pathway (GO:0035567)2.36885043
135synaptic vesicle docking involved in exocytosis (GO:0016081)2.36032928
136central nervous system projection neuron axonogenesis (GO:0021952)2.35308313
137positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.34720922
138negative regulation of vascular permeability (GO:0043116)2.34495270
139epithelial cell-cell adhesion (GO:0090136)2.34024712
140regulation of catenin import into nucleus (GO:0035412)2.32602062
141renal system development (GO:0072001)2.31413108
142negative regulation of axon guidance (GO:1902668)2.30865919
143establishment or maintenance of apical/basal cell polarity (GO:0035088)2.28538566
144establishment or maintenance of bipolar cell polarity (GO:0061245)2.28538566
145retina vasculature morphogenesis in camera-type eye (GO:0061299)2.27535519
146neuron projection extension (GO:1990138)2.27055732
147bundle of His cell to Purkinje myocyte communication (GO:0086069)2.26943760
148heart morphogenesis (GO:0003007)2.26774589
149substrate adhesion-dependent cell spreading (GO:0034446)2.26546538
150cytoplasmic mRNA processing body assembly (GO:0033962)2.26412638
151asymmetric protein localization (GO:0008105)2.26404569
152stress fiber assembly (GO:0043149)2.26134816
153regulation of dendritic spine morphogenesis (GO:0061001)2.26095936
154regulation of short-term neuronal synaptic plasticity (GO:0048172)2.26013114
155lymph vessel development (GO:0001945)2.25273119
156sodium ion export (GO:0071436)2.24970163
157nucleus localization (GO:0051647)2.24605303
158epithelial cell differentiation involved in prostate gland development (GO:0060742)2.24292976
159ectodermal placode formation (GO:0060788)2.23590099
160dendritic spine organization (GO:0097061)2.22543913
161regulation of cardioblast differentiation (GO:0051890)2.22501222

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human3.79790039
2EZH2_22144423_ChIP-Seq_EOC_Human2.55638718
3ZNF263_19887448_ChIP-Seq_K562_Human2.52938945
4THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.47405494
5STAT6_21828071_ChIP-Seq_BEAS2B_Human2.44142097
6EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.43891253
7SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.41797212
8ZFP281_18757296_ChIP-ChIP_E14_Mouse2.34840010
9EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.30323329
10ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.18501407
11WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.18113770
12RNF2_18974828_ChIP-Seq_MESCs_Mouse2.13549889
13EZH2_18974828_ChIP-Seq_MESCs_Mouse2.13549889
14TRIM28_21343339_ChIP-Seq_HEK293_Human2.10706502
15* ZFP281_27345836_Chip-Seq_ESCs_Mouse2.07113226
16* KDM2B_26808549_Chip-Seq_K562_Human1.97982826
17TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.96430474
18TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.91514929
19ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.90054009
20SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.89344108
21ERG_21242973_ChIP-ChIP_JURKAT_Human1.87501870
22JARID2_20064375_ChIP-Seq_MESCs_Mouse1.86939676
23NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.84520768
24DROSHA_22980978_ChIP-Seq_HELA_Human1.83899608
25JARID2_20075857_ChIP-Seq_MESCs_Mouse1.82584535
26EZH2_27304074_Chip-Seq_ESCs_Mouse1.81723360
27* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.81043216
28RNF2_27304074_Chip-Seq_ESCs_Mouse1.79544187
29SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.77309346
30TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.75676874
31SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.74638884
32NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.72067285
33TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.71622332
34EED_16625203_ChIP-ChIP_MESCs_Mouse1.71611410
35* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.70876280
36SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.70843045
37PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.68227916
38TCF7_22412390_ChIP-Seq_EML_Mouse1.65438086
39SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.64604493
40TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.63157883
41DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.60986648
42HIF1A_21447827_ChIP-Seq_MCF-7_Human1.59803406
43MTF2_20144788_ChIP-Seq_MESCs_Mouse1.59633323
44VDR_21846776_ChIP-Seq_THP-1_Human1.58699612
45RING1B_27294783_Chip-Seq_NPCs_Mouse1.58453009
46TP53_22127205_ChIP-Seq_IMR90_Human1.57859853
47ATF3_27146783_Chip-Seq_COLON_Human1.57467079
48MYC_22102868_ChIP-Seq_BL_Human1.57018556
49ESR2_21235772_ChIP-Seq_MCF-7_Human1.56378736
50EZH2_27294783_Chip-Seq_ESCs_Mouse1.56287213
51SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.55410856
52SUZ12_27294783_Chip-Seq_ESCs_Mouse1.55221626
53NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.52392851
54ZNF217_24962896_ChIP-Seq_MCF-7_Human1.51950795
55RING1B_27294783_Chip-Seq_ESCs_Mouse1.50274551
56EP300_21415370_ChIP-Seq_HL-1_Mouse1.49598628
57WT1_25993318_ChIP-Seq_PODOCYTE_Human1.49379690
58ISL1_27105846_Chip-Seq_CPCs_Mouse1.47924898
59SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.45831774
60RARG_19884340_ChIP-ChIP_MEFs_Mouse1.45252441
61SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.43808931
62KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.42440747
63TP53_20018659_ChIP-ChIP_R1E_Mouse1.41488418
64ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.40389523
65ESR1_20079471_ChIP-ChIP_T-47D_Human1.39988398
66NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.38728003
67CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.38211868
68* KDM2B_26808549_Chip-Seq_DND41_Human1.36963861
69ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.36918338
70DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.36895506
71RARB_27405468_Chip-Seq_BRAIN_Mouse1.36094746
72SMC4_20622854_ChIP-Seq_HELA_Human1.34359934
73TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.33993341
74POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.33621219
75TET1_21451524_ChIP-Seq_MESCs_Mouse1.32094290
76UBF1/2_26484160_Chip-Seq_HMECs_Human1.31766709
77P68_20966046_ChIP-Seq_HELA_Human1.31073210
78EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.30999856
79* KDM2B_26808549_Chip-Seq_JURKAT_Human1.30084501
80CLOCK_20551151_ChIP-Seq_293T_Human1.29087958
81TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.28048767
82* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.28029972
83* PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.27211476
84AHR_22903824_ChIP-Seq_MCF-7_Human1.27202644
85SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.26270311
86* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.26257555
87ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.26067938
88* ELK3_25401928_ChIP-Seq_HUVEC_Human1.22719997
89PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.21076429
90GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.21075069
91* SA1_27219007_Chip-Seq_ERYTHROID_Human1.20783614
92SOX2_27498859_Chip-Seq_STOMACH_Mouse1.20237285
93WT1_19549856_ChIP-ChIP_CCG9911_Human1.19869253
94SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.19821963
95SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.19821963
96* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.19576841
97* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.19342675
98SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.17638441
99* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.16879211
100SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.16785515
101ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.16363265
102TET1_21490601_ChIP-Seq_MESCs_Mouse1.14699378
103MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.14649599
104LXR_22292898_ChIP-Seq_THP-1_Human1.13414067
105* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.11563350
106SRY_22984422_ChIP-ChIP_TESTIS_Rat1.11305027
107* RACK7_27058665_Chip-Seq_MCF-7_Human1.11135689
108* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.11102206
109NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.09597044
110NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.09491353
111* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.08628082
112RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.08297773
113* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.08287832
114ARNT_22903824_ChIP-Seq_MCF-7_Human1.07630353
115NFIB_24661679_ChIP-Seq_LUNG_Mouse1.06927297
116DNAJC2_21179169_ChIP-ChIP_NT2_Human1.06311884
117* KLF5_25053715_ChIP-Seq_YYC3_Human1.06217798
118* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.05988983
119KLF4_18555785_ChIP-Seq_MESCs_Mouse1.05696178
120ESR1_21235772_ChIP-Seq_MCF-7_Human1.04912234
121SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.04899220
122KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.04777430
123TCF4_18268006_ChIP-ChIP_LS174T_Human1.04203363
124FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.04045467
125* TP63_22573176_ChIP-Seq_HFKS_Human1.02902257
126* CREB1_26743006_Chip-Seq_LNCaP_Human1.02591758
127HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.02267559
128TCF3_18692474_ChIP-Seq_MEFs_Mouse1.02072943
129* CTCF_27219007_Chip-Seq_Bcells_Human1.01714563
130CDX2_20551321_ChIP-Seq_CACO-2_Human1.01426178
131RUNX1_27514584_Chip-Seq_MCF-7_Human1.01289521
132ESR1_15608294_ChIP-ChIP_MCF-7_Human1.01029422
133* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.00685295
134TP53_23651856_ChIP-Seq_MEFs_Mouse1.00684038
135* NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.00237484
136CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.00002387
137RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.98002134
138TP53_16413492_ChIP-PET_HCT116_Human0.97035640
139AR_19668381_ChIP-Seq_PC3_Human0.95797505
140CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.95619679
141POU5F1_16518401_ChIP-PET_MESCs_Mouse0.94964015
142SMAD3_21741376_ChIP-Seq_HESCs_Human0.94382839
143STAT3_1855785_ChIP-Seq_MESCs_Mouse0.93558711
144* NCOR1_26117541_ChIP-Seq_K562_Human0.93500870
145SALL1_21062744_ChIP-ChIP_HESCs_Human0.93216985
146SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.92156911
147TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.91921163
148CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.91271369
149HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.91240084
150PPARA_22158963_ChIP-Seq_LIVER_Mouse0.91043286
151* SOX2_20726797_ChIP-Seq_SW620_Human0.90392823
152ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.90164165
153* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.89687217
154SMAD_19615063_ChIP-ChIP_OVARY_Human0.87954558

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004272_abnormal_basement_membrane4.91208869
2MP0003705_abnormal_hypodermis_morpholog3.50019145
3MP0000537_abnormal_urethra_morphology3.08546898
4MP0010368_abnormal_lymphatic_system2.96450470
5MP0005623_abnormal_meninges_morphology2.93436134
6MP0000579_abnormal_nail_morphology2.91864632
7MP0010234_abnormal_vibrissa_follicle2.83904212
8MP0004145_abnormal_muscle_electrophysio2.77989568
9MP0005257_abnormal_intraocular_pressure2.60006543
10MP0003941_abnormal_skin_development2.48163055
11MP0004859_abnormal_synaptic_plasticity2.42140305
12MP0003453_abnormal_keratinocyte_physiol2.36276761
13MP0003279_aneurysm2.33803816
14MP0002877_abnormal_melanocyte_morpholog2.17380808
15MP0003122_maternal_imprinting2.17081707
16MP0004858_abnormal_nervous_system2.06241788
17MP0010030_abnormal_orbit_morphology2.01017876
18MP0002060_abnormal_skin_morphology1.95843891
19MP0003942_abnormal_urinary_system1.91317615
20MP0003283_abnormal_digestive_organ1.90227469
21MP0005409_darkened_coat_color1.88689931
22MP0001849_ear_inflammation1.84654914
23MP0005167_abnormal_blood-brain_barrier1.82007877
24MP0003115_abnormal_respiratory_system1.81035804
25MP0000534_abnormal_ureter_morphology1.73153580
26MP0002098_abnormal_vibrissa_morphology1.72689061
27MP0005501_abnormal_skin_physiology1.69724390
28MP0004264_abnormal_extraembryonic_tissu1.69454061
29MP0004133_heterotaxia1.67639225
30MP0003385_abnormal_body_wall1.67290605
31MP0000778_abnormal_nervous_system1.66037970
32MP0001879_abnormal_lymphatic_vessel1.63048639
33MP0009780_abnormal_chondrocyte_physiolo1.61748883
34MP0000678_abnormal_parathyroid_gland1.61622934
35MP0002089_abnormal_postnatal_growth/wei1.60770457
36MP0009053_abnormal_anal_canal1.58211233
37MP0005023_abnormal_wound_healing1.56319209
38MP0001348_abnormal_lacrimal_gland1.54918311
39MP0002653_abnormal_ependyma_morphology1.53313096
40MP0003119_abnormal_digestive_system1.52226295
41MP0000428_abnormal_craniofacial_morphol1.50265406
42MP0005058_abnormal_lysosome_morphology1.44370965
43MP0005451_abnormal_body_composition1.42696294
44MP0005076_abnormal_cell_differentiation1.38049286
45MP0000049_abnormal_middle_ear1.37055518
46MP0001216_abnormal_epidermal_layer1.36139871
47MP0005275_abnormal_skin_tensile1.35301057
48MP0002697_abnormal_eye_size1.34897415
49MP0003123_paternal_imprinting1.33875978
50MP0005187_abnormal_penis_morphology1.32610352
51MP0009384_cardiac_valve_regurgitation1.31454120
52MP0005248_abnormal_Harderian_gland1.31202661
53MP0002932_abnormal_joint_morphology1.30614107
54MP0003935_abnormal_craniofacial_develop1.30594826
55MP0010678_abnormal_skin_adnexa1.30553391
56MP0002282_abnormal_trachea_morphology1.26783930
57MP0004885_abnormal_endolymph1.25700212
58MP0003121_genomic_imprinting1.25500454
59MP0004782_abnormal_surfactant_physiolog1.24021146
60MP0009250_abnormal_appendicular_skeleto1.22863309
61MP0008438_abnormal_cutaneous_collagen1.22596544
62MP0002254_reproductive_system_inflammat1.21404702
63* MP0003861_abnormal_nervous_system1.19666128
64MP0003632_abnormal_nervous_system1.18050383
65MP0003755_abnormal_palate_morphology1.16853112
66* MP0003635_abnormal_synaptic_transmissio1.15799619
67MP0001958_emphysema1.14137290
68MP0002108_abnormal_muscle_morphology1.14125650
69MP0010771_integument_phenotype1.14033045
70MP0000003_abnormal_adipose_tissue1.12473435
71MP0002234_abnormal_pharynx_morphology1.12200946
72MP0000516_abnormal_urinary_system1.11253558
73MP0005367_renal/urinary_system_phenotyp1.11253558
74MP0000733_abnormal_muscle_development1.07466067
75MP0000767_abnormal_smooth_muscle1.06827234
76MP0002896_abnormal_bone_mineralization1.06730741
77MP0002925_abnormal_cardiovascular_devel1.06131257
78MP0004185_abnormal_adipocyte_glucose1.05249398
79MP0002116_abnormal_craniofacial_bone1.05048844
80MP0005171_absent_coat_pigmentation1.04015792
81MP0004197_abnormal_fetal_growth/weight/1.03057718
82MP0003566_abnormal_cell_adhesion1.02619502
83MP0009840_abnormal_foam_cell1.02513789
84MP0000377_abnormal_hair_follicle1.01964479
85MP0004233_abnormal_muscle_weight1.01911695
86* MP0002184_abnormal_innervation0.98329746
87MP0002249_abnormal_larynx_morphology0.98039352
88MP0004270_analgesia0.97695571
89MP0002084_abnormal_developmental_patter0.94865870
90MP0000858_altered_metastatic_potential0.94619989
91MP0008260_abnormal_autophagy0.94417763
92MP0004084_abnormal_cardiac_muscle0.94170191
93MP0003937_abnormal_limbs/digits/tail_de0.92175912
94MP0004085_abnormal_heartbeat0.91373958
95MP0000955_abnormal_spinal_cord0.91059877
96MP0002152_abnormal_brain_morphology0.90485915
97MP0000432_abnormal_head_morphology0.89516398
98* MP0002081_perinatal_lethality0.88966316
99MP0001340_abnormal_eyelid_morphology0.88938299
100MP0003787_abnormal_imprinting0.88705615
101MP0006138_congestive_heart_failure0.88278323
102MP0010352_gastrointestinal_tract_polyps0.87675215
103MP0005508_abnormal_skeleton_morphology0.87203092
104MP0002085_abnormal_embryonic_tissue0.86693681
105MP0002063_abnormal_learning/memory/cond0.85400592
106MP0003329_amyloid_beta_deposits0.85370712
107MP0000762_abnormal_tongue_morphology0.85348033
108MP0000467_abnormal_esophagus_morphology0.84875965
109MP0000751_myopathy0.84589976
110MP0002233_abnormal_nose_morphology0.84344652
111MP0005375_adipose_tissue_phenotype0.84097860
112MP0000383_abnormal_hair_follicle0.84083722
113MP0005503_abnormal_tendon_morphology0.83848286
114MP0002938_white_spotting0.83559347
115MP0003091_abnormal_cell_migration0.83460346
116MP0003191_abnormal_cellular_cholesterol0.82569391
117MP0001614_abnormal_blood_vessel0.79560134
118MP0004087_abnormal_muscle_fiber0.79231619
119MP0009931_abnormal_skin_appearance0.79177072
120MP0005666_abnormal_adipose_tissue0.78793003
121MP0002111_abnormal_tail_morphology0.78703327
122MP0002092_abnormal_eye_morphology0.78548300
123MP0004811_abnormal_neuron_physiology0.78061300
124MP0005621_abnormal_cell_physiology0.77777711
125MP0001299_abnormal_eye_distance/0.77278396
126MP0001915_intracranial_hemorrhage0.76984753
127MP0003634_abnormal_glial_cell0.76578542
128MP0000462_abnormal_digestive_system0.76186170
129MP0010630_abnormal_cardiac_muscle0.76135825
130MP0002086_abnormal_extraembryonic_tissu0.75610673
131MP0002796_impaired_skin_barrier0.74878861
132MP0005197_abnormal_uvea_morphology0.74677015
133MP0000566_synostosis0.74084519
134MP0001784_abnormal_fluid_regulation0.73502710
135MP0009278_abnormal_bone_marrow0.72788862
136MP0005670_abnormal_white_adipose0.72293304
137* MP0002882_abnormal_neuron_morphology0.71824601
138MP0000013_abnormal_adipose_tissue0.71426083
139MP0000627_abnormal_mammary_gland0.71399324
140MP0003172_abnormal_lysosome_physiology0.71359000
141MP0001243_abnormal_dermal_layer0.71014805
142MP0002128_abnormal_blood_circulation0.70517432
143MP0009672_abnormal_birth_weight0.69769276
144MP0001730_embryonic_growth_arrest0.69051392

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)5.57361322
2Wrist flexion contracture (HP:0001239)4.62857626
3Overgrowth (HP:0001548)4.32980541
4Premature rupture of membranes (HP:0001788)3.98067867
5Cerebral aneurysm (HP:0004944)3.93276976
6Skull defect (HP:0001362)3.75560679
7Shallow orbits (HP:0000586)3.75463133
8Broad face (HP:0000283)3.74181239
9Fragile skin (HP:0001030)3.41715420
10Distal lower limb amyotrophy (HP:0008944)3.13884832
11Upper limb amyotrophy (HP:0009129)3.09947335
12Distal upper limb amyotrophy (HP:0007149)3.09947335
13Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.97523902
14Short 4th metacarpal (HP:0010044)2.97523902
15Broad metatarsal (HP:0001783)2.96756948
16Hip contracture (HP:0003273)2.93174871
17High pitched voice (HP:0001620)2.84543212
18Neoplasm of the oral cavity (HP:0100649)2.83992096
19Neonatal death (HP:0003811)2.82021796
20Cervical subluxation (HP:0003308)2.78250133
21Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.73656300
22Short 1st metacarpal (HP:0010034)2.73656300
23Vertebral clefting (HP:0008428)2.67596754
24Arterial tortuosity (HP:0005116)2.66915343
25Lymphangioma (HP:0100764)2.65632961
26Mildly elevated creatine phosphokinase (HP:0008180)2.64355885
27Obstructive sleep apnea (HP:0002870)2.62277699
28Abnormal vertebral ossification (HP:0100569)2.61658977
29Advanced eruption of teeth (HP:0006288)2.61530747
30Pterygium (HP:0001059)2.59635139
31Short nail (HP:0001799)2.58504125
32Selective tooth agenesis (HP:0001592)2.51429999
33Aplasia involving bones of the upper limbs (HP:0009823)2.48937794
34Aplasia of the phalanges of the hand (HP:0009802)2.48937794
35Aplasia involving bones of the extremities (HP:0009825)2.48937794
36Atrophic scars (HP:0001075)2.48248759
37Spinal rigidity (HP:0003306)2.44170031
38Milia (HP:0001056)2.43494029
39Vascular tortuosity (HP:0004948)2.42550997
40Ulnar bowing (HP:0003031)2.40069440
41Abnormality of the 4th metacarpal (HP:0010012)2.38303137
42Abnormality of the 1st metacarpal (HP:0010009)2.38171989
43Hyperacusis (HP:0010780)2.37884403
44Natal tooth (HP:0000695)2.36513921
45Myotonia (HP:0002486)2.36293959
46Renal duplication (HP:0000075)2.34383744
47Short phalanx of the thumb (HP:0009660)2.33243088
48Flat acetabular roof (HP:0003180)2.31452978
49Lower limb amyotrophy (HP:0007210)2.31139539
50Flat cornea (HP:0007720)2.29213269
51Stridor (HP:0010307)2.23220543
52Limited hip movement (HP:0008800)2.23053501
53Hemorrhage of the eye (HP:0011885)2.22368049
54Achilles tendon contracture (HP:0001771)2.17450572
55Difficulty climbing stairs (HP:0003551)2.17307030
56Mitral regurgitation (HP:0001653)2.15539650
57Long palpebral fissure (HP:0000637)2.14777418
58Absent eyelashes (HP:0000561)2.14360860
59Abnormality of the distal phalanges of the toes (HP:0010182)2.13315233
60Radial bowing (HP:0002986)2.13266281
61Elfin facies (HP:0004428)2.11480536
62Pili torti (HP:0003777)2.11101491
63Laryngomalacia (HP:0001601)2.09636232
64Midline defect of the nose (HP:0004122)2.08153850
65Tracheal stenosis (HP:0002777)2.06871783
66Hand muscle atrophy (HP:0009130)2.06308143
67Cutaneous finger syndactyly (HP:0010554)2.05598016
68Long eyelashes (HP:0000527)2.04870230
69Morphological abnormality of the middle ear (HP:0008609)2.04285382
70Neonatal short-limb short stature (HP:0008921)2.03073770
71Trismus (HP:0000211)2.02925483
72Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)2.00952382
73Absent eyebrow (HP:0002223)2.00692842
74Thin bony cortex (HP:0002753)2.00015364
75Ankyloglossia (HP:0010296)1.99794859
76Abnormality of the distal phalanx of the thumb (HP:0009617)1.99517318
77Aneurysm (HP:0002617)1.98880929
78Insomnia (HP:0100785)1.98726765
79Distal lower limb muscle weakness (HP:0009053)1.97795337
80Arnold-Chiari malformation (HP:0002308)1.96011742
81Abnormality of the Achilles tendon (HP:0005109)1.95956818
82Coxa vara (HP:0002812)1.94831492
83J-shaped sella turcica (HP:0002680)1.94361504
84Alopecia of scalp (HP:0002293)1.93919939
85Nail dystrophy (HP:0008404)1.92925451
86Vertebral compression fractures (HP:0002953)1.92916994
87Abnormality of dentin (HP:0010299)1.92463138
88Bronchomalacia (HP:0002780)1.91933269
89Right ventricular cardiomyopathy (HP:0011663)1.91664393
90Blue sclerae (HP:0000592)1.91133236
91Renovascular hypertension (HP:0100817)1.89905661
92Flexion contracture of toe (HP:0005830)1.89793683
93Joint contractures involving the joints of the feet (HP:0100492)1.89793683
94Ectopia lentis (HP:0001083)1.89611377
95Bicornuate uterus (HP:0000813)1.89430373
96Pointed chin (HP:0000307)1.89238362
97Buphthalmos (HP:0000557)1.88540288
98Subacute progressive viral hepatitis (HP:0006572)1.88099618
99Overriding aorta (HP:0002623)1.88048748
100Acanthosis nigricans (HP:0000956)1.86982164
101Aortic dissection (HP:0002647)1.86171828
102Astrocytoma (HP:0009592)1.85689351
103Abnormality of the astrocytes (HP:0100707)1.85689351
104Hepatoblastoma (HP:0002884)1.83430501
105Mask-like facies (HP:0000298)1.83229914
106Mitral valve prolapse (HP:0001634)1.82376550
107Biconcave vertebral bodies (HP:0004586)1.81218144
108Turricephaly (HP:0000262)1.80033144
109Coronal craniosynostosis (HP:0004440)1.77447001
110Progressive sensorineural hearing impairment (HP:0000408)1.76840201
111Abnormality of the lower motor neuron (HP:0002366)1.76341349
112Congenital hip dislocation (HP:0001374)1.75928556
113Hypoplasia of dental enamel (HP:0006297)1.75850899
114Ridged nail (HP:0001807)1.75848247
115Bladder diverticulum (HP:0000015)1.75134185
116Cutaneous syndactyly (HP:0012725)1.75103215
117Deviation of the thumb (HP:0009603)1.75050511
118Patellar dislocation (HP:0002999)1.74462833
119Bowing of the arm (HP:0006488)1.73795005
120Bowed forearm bones (HP:0003956)1.73795005
121Cerebral inclusion bodies (HP:0100314)1.73054125
122Germ cell neoplasia (HP:0100728)1.72695050
123Aortic aneurysm (HP:0004942)1.71689582
124Abnormality of the pubic bones (HP:0003172)1.71176091
125Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.70720595
126Sprengel anomaly (HP:0000912)1.70692803
127Nuclear cataract (HP:0100018)1.70172651
128Abnormal hair laboratory examination (HP:0003328)1.70059515
129Thick nail (HP:0001805)1.69815198
130Urethral obstruction (HP:0000796)1.68695608
131Hypoplasia of the iris (HP:0007676)1.68114134
132Choanal stenosis (HP:0000452)1.67987184
133Macroorchidism (HP:0000053)1.67716493
134Abnormal ossification of hand bones (HP:0005921)1.67655722
135Glomerulosclerosis (HP:0000096)1.67499542
136Asymmetry of the thorax (HP:0001555)1.67051233
137Plantar hyperkeratosis (HP:0007556)1.67023598
138Enlarged penis (HP:0000040)1.65574766
139Bilateral microphthalmos (HP:0007633)1.64747683
140Wormian bones (HP:0002645)1.64618669
141Midface retrusion (HP:0011800)1.64341259
142Difficulty running (HP:0009046)1.63957366
143Congenital glaucoma (HP:0001087)1.63377451
144Abnormality of oral frenula (HP:0000190)1.62701491
145Elbow flexion contracture (HP:0002987)1.62539946
146Joint laxity (HP:0001388)1.62346865
147Ankle contracture (HP:0006466)1.62052596
148Esophageal atresia (HP:0002032)1.61863441
149Neurofibrillary tangles (HP:0002185)1.61739877
150Genu recurvatum (HP:0002816)1.61611522
151Disproportionate tall stature (HP:0001519)1.61587481
152Broad ribs (HP:0000885)1.61414467
153Shawl scrotum (HP:0000049)1.58715546
154Osteolytic defects of the hand bones (HP:0009699)1.58682088
155Pseudobulbar signs (HP:0002200)1.57507299
156Focal segmental glomerulosclerosis (HP:0000097)1.57039280
157Termporal pattern (HP:0011008)1.56475774
158Insidious onset (HP:0003587)1.56475774
159Fragile nails (HP:0001808)1.54069248
160Increased connective tissue (HP:0009025)1.53922296
161Neoplasm of the heart (HP:0100544)1.53764051
162Dilatation of the ascending aorta (HP:0005111)1.51938248

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SCYL25.09033719
2MST1R4.51068561
3TIE14.16872003
4IRAK33.47577565
5SIK22.99928521
6EPHB22.85095958
7SMG12.41638264
8MARK12.31941654
9RIPK12.24299219
10TRIB32.21302560
11PKN22.04039619
12MAP3K91.97177646
13PDGFRA1.96507625
14LATS11.94950349
15DDR21.90828544
16EPHA21.89284641
17LATS21.88120515
18TYRO31.84911840
19FGFR41.80587808
20PRKD31.71892248
21ERN11.66855157
22PTK61.66836419
23ICK1.65375080
24FER1.64821781
25PAK61.64627516
26TTN1.51047500
27MAP3K101.45846911
28EPHA41.45839890
29PTK21.42451948
30PAK41.36994109
31FGFR21.36582241
32KSR11.36277665
33CDK121.35684562
34KSR21.20738000
35DAPK21.18563683
36BMX1.18157521
37NTRK31.15649104
38NTRK21.14775430
39ERBB21.12152962
40NTRK11.11976303
41TESK11.11920887
42CAMK1G1.09372015
43IRAK21.05836166
44MAP3K41.05593344
45PAK31.04971980
46KDR1.04422055
47ALK1.04313100
48EEF2K0.99170653
49MINK10.98466349
50FGFR10.97189235
51MTOR0.96547756
52LMTK20.95826202
53PRKD20.91347419
54SIK10.91123747
55RET0.90971368
56PAK20.90714361
57DMPK0.90538573
58PRPF4B0.89803611
59CSNK1A1L0.88338944
60PTK2B0.86544129
61ARAF0.84739272
62STK380.82358433
63NEK20.75602814
64PDGFRB0.75449866
65EPHB10.75018802
66MET0.73270294
67NEK10.72317642
68PHKG10.72269134
69PHKG20.72269134
70CAMKK10.71064568
71MAP3K60.70023454
72MAP3K30.67796736
73CAMK1D0.66539402
74PRKG20.66457934
75CDK50.65436829
76CDC42BPA0.64204064
77MAP3K20.63847214
78CSNK1G20.63065720
79ERBB30.62824752
80UHMK10.62550958
81TGFBR10.61387416
82TAOK10.61058077
83MAP3K70.60948840
84NME20.60766573
85CDK80.59469611
86MARK20.57655042
87ROCK10.57594578
88PRKCI0.57592469
89PNCK0.56686995
90BCR0.55680532
91TGFBR20.55215333
92PRKCH0.53849586
93RPS6KB20.53253644
94BRD40.51975850
95CSNK1G30.50602544
96RPS6KC10.49564812
97RPS6KL10.49564812
98SRC0.49314384
99DYRK1B0.48247934
100CDK60.47876419
101CDK140.47830462
102CDK70.47741925
103MAP2K40.47159822
104CDK150.46546389
105LIMK10.46419027
106CHUK0.46196867
107MAPKAPK30.46085111
108PRKD10.45199977
109CSNK1G10.44390559
110CDK180.43855825
111IRAK40.43589681
112RPS6KA20.43561394
113AKT20.42540902
114ERBB40.42400727
115ROCK20.42049244
116STK110.41980857
117MAP2K20.41322496
118HIPK20.40879393
119MAP2K10.40197902
120PDPK10.40062476
121MAPK90.39384748
122FYN0.38601228
123CAMK2G0.38051290
124CAMK2B0.38004458
125CDK11A0.37764618
126MAPK100.37550558
127LRRK20.37511522
128CSNK1D0.37258136
129MAP3K130.36104456
130IRAK10.35757019
131TAOK20.33158792
132PIM20.32660657
133CDK90.32250557
134MAP3K80.31803867
135ILK0.31802223
136RPS6KA60.31688370
137MAP3K10.31502945
138BRAF0.31495351
139WNK40.31382372
140MAPK150.30407995
141MAP3K110.29709558
142RPS6KA10.28115468
143MAPKAPK20.26885357
144FLT30.26716962
145MAPK80.24453894
146TRPM70.24297530
147MAPK110.23168635
148MUSK0.23019747
149CSF1R0.21094420
150RPS6KA40.20237813

Predicted pathways (KEGG)

RankGene SetZ-score
1* ECM-receptor interaction_Homo sapiens_hsa045122.62821361
2Axon guidance_Homo sapiens_hsa043602.21933558
3Basal cell carcinoma_Homo sapiens_hsa052172.12583294
4Hippo signaling pathway_Homo sapiens_hsa043901.98203308
5Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.94082076
6Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.87972534
7Focal adhesion_Homo sapiens_hsa045101.85256845
8Adherens junction_Homo sapiens_hsa045201.82505875
9Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.80119800
10Small cell lung cancer_Homo sapiens_hsa052221.76122030
11Other glycan degradation_Homo sapiens_hsa005111.72560238
12Tight junction_Homo sapiens_hsa045301.71666933
13Hedgehog signaling pathway_Homo sapiens_hsa043401.66638484
14Proteoglycans in cancer_Homo sapiens_hsa052051.60944074
15Amoebiasis_Homo sapiens_hsa051461.58795226
16Cyanoamino acid metabolism_Homo sapiens_hsa004601.54993111
17Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.49851974
18Glycosaminoglycan degradation_Homo sapiens_hsa005311.49217749
19Endometrial cancer_Homo sapiens_hsa052131.48279127
20Dilated cardiomyopathy_Homo sapiens_hsa054141.47569281
21Melanogenesis_Homo sapiens_hsa049161.47526403
22Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.47499644
23Fatty acid biosynthesis_Homo sapiens_hsa000611.46522986
24Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.46129283
25Notch signaling pathway_Homo sapiens_hsa043301.44715074
26Gap junction_Homo sapiens_hsa045401.42471186
27Dorso-ventral axis formation_Homo sapiens_hsa043201.38371490
28Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.35362206
29Glioma_Homo sapiens_hsa052141.34363593
30Galactose metabolism_Homo sapiens_hsa000521.30381468
31Prion diseases_Homo sapiens_hsa050201.29301865
32Wnt signaling pathway_Homo sapiens_hsa043101.28866163
33Circadian entrainment_Homo sapiens_hsa047131.28844978
34Estrogen signaling pathway_Homo sapiens_hsa049151.27376108
35Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.27312786
36Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.24640216
37Bladder cancer_Homo sapiens_hsa052191.23161365
38Pentose phosphate pathway_Homo sapiens_hsa000301.22674749
39Fructose and mannose metabolism_Homo sapiens_hsa000511.22192752
40Rap1 signaling pathway_Homo sapiens_hsa040151.20588189
41Colorectal cancer_Homo sapiens_hsa052101.20074084
42Synaptic vesicle cycle_Homo sapiens_hsa047211.19006623
43AMPK signaling pathway_Homo sapiens_hsa041521.18634201
44Renal cell carcinoma_Homo sapiens_hsa052111.18081813
45Gastric acid secretion_Homo sapiens_hsa049711.18056364
46Long-term potentiation_Homo sapiens_hsa047201.15550384
47Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.15547444
48MicroRNAs in cancer_Homo sapiens_hsa052061.15119476
49Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.14432337
50Glutamatergic synapse_Homo sapiens_hsa047241.13618731
51GABAergic synapse_Homo sapiens_hsa047271.13422626
52Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.11034134
53Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.10761181
54Thyroid hormone signaling pathway_Homo sapiens_hsa049191.09711285
55ErbB signaling pathway_Homo sapiens_hsa040121.09372102
56GnRH signaling pathway_Homo sapiens_hsa049121.08149006
57Dopaminergic synapse_Homo sapiens_hsa047281.08106759
58Nitrogen metabolism_Homo sapiens_hsa009101.06832746
59Protein digestion and absorption_Homo sapiens_hsa049741.05562514
60Oxytocin signaling pathway_Homo sapiens_hsa049211.04996551
61Chronic myeloid leukemia_Homo sapiens_hsa052201.04949213
62N-Glycan biosynthesis_Homo sapiens_hsa005101.03036307
63Cocaine addiction_Homo sapiens_hsa050301.02971057
64Pathways in cancer_Homo sapiens_hsa052001.02205123
65Cholinergic synapse_Homo sapiens_hsa047251.01836706
66VEGF signaling pathway_Homo sapiens_hsa043701.00960657
67Salivary secretion_Homo sapiens_hsa049701.00914457
68Aldosterone synthesis and secretion_Homo sapiens_hsa049251.00842235
69Nicotine addiction_Homo sapiens_hsa050331.00133636
70Biosynthesis of amino acids_Homo sapiens_hsa012300.98294021
71Renin secretion_Homo sapiens_hsa049240.97748692
72Acute myeloid leukemia_Homo sapiens_hsa052210.97580145
73mTOR signaling pathway_Homo sapiens_hsa041500.97249365
74AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.95734767
75Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.94305683
76Regulation of actin cytoskeleton_Homo sapiens_hsa048100.94257010
77Amphetamine addiction_Homo sapiens_hsa050310.91722662
78Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.90706605
79Viral myocarditis_Homo sapiens_hsa054160.90253508
80Neurotrophin signaling pathway_Homo sapiens_hsa047220.87734582
81Long-term depression_Homo sapiens_hsa047300.86753637
82Morphine addiction_Homo sapiens_hsa050320.86710972
83Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.86012517
84Insulin secretion_Homo sapiens_hsa049110.85081633
85Central carbon metabolism in cancer_Homo sapiens_hsa052300.84024784
86Vibrio cholerae infection_Homo sapiens_hsa051100.83723968
87Leukocyte transendothelial migration_Homo sapiens_hsa046700.83279897
88Olfactory transduction_Homo sapiens_hsa047400.82863020
89TGF-beta signaling pathway_Homo sapiens_hsa043500.82683141
90Phospholipase D signaling pathway_Homo sapiens_hsa040720.81469145
91PI3K-Akt signaling pathway_Homo sapiens_hsa041510.81373227
92Non-small cell lung cancer_Homo sapiens_hsa052230.80928709
93Type II diabetes mellitus_Homo sapiens_hsa049300.80280806
94Lysine degradation_Homo sapiens_hsa003100.79726938
95cAMP signaling pathway_Homo sapiens_hsa040240.78797273
96cGMP-PKG signaling pathway_Homo sapiens_hsa040220.77952381
97Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.76888932
98Toxoplasmosis_Homo sapiens_hsa051450.74168135
99Bile secretion_Homo sapiens_hsa049760.72626694
100Thyroid cancer_Homo sapiens_hsa052160.72540593
101Hepatitis C_Homo sapiens_hsa051600.71545904
102Melanoma_Homo sapiens_hsa052180.69636720
103Vitamin B6 metabolism_Homo sapiens_hsa007500.69144033
104Pancreatic cancer_Homo sapiens_hsa052120.68242847
105Ras signaling pathway_Homo sapiens_hsa040140.68221934
106MAPK signaling pathway_Homo sapiens_hsa040100.67266897
107Inositol phosphate metabolism_Homo sapiens_hsa005620.66706796
108Choline metabolism in cancer_Homo sapiens_hsa052310.66136263
109Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.65928678
110Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.65554811
111Phosphatidylinositol signaling system_Homo sapiens_hsa040700.65454079
112Oocyte meiosis_Homo sapiens_hsa041140.65316752
113Endocytosis_Homo sapiens_hsa041440.63105683
114Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.62554464
115Longevity regulating pathway - mammal_Homo sapiens_hsa042110.61225748
116Thyroid hormone synthesis_Homo sapiens_hsa049180.61144759
117Salmonella infection_Homo sapiens_hsa051320.60622470
118Insulin signaling pathway_Homo sapiens_hsa049100.60598468
119Prostate cancer_Homo sapiens_hsa052150.59087229
120Glucagon signaling pathway_Homo sapiens_hsa049220.58375339
121Prolactin signaling pathway_Homo sapiens_hsa049170.57527157
122Vascular smooth muscle contraction_Homo sapiens_hsa042700.56810451
123Insulin resistance_Homo sapiens_hsa049310.56633236
124Sulfur relay system_Homo sapiens_hsa041220.56058414
125Sphingolipid metabolism_Homo sapiens_hsa006000.54540057
126Apoptosis_Homo sapiens_hsa042100.53370890
1272-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.52647695
128Lysosome_Homo sapiens_hsa041420.51565195
129Steroid biosynthesis_Homo sapiens_hsa001000.51186233
130TNF signaling pathway_Homo sapiens_hsa046680.50353357
131Adipocytokine signaling pathway_Homo sapiens_hsa049200.50267683
132Shigellosis_Homo sapiens_hsa051310.49501929
133Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.45294755
134Sphingolipid signaling pathway_Homo sapiens_hsa040710.42784438
135Arginine biosynthesis_Homo sapiens_hsa002200.42291748

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