AGMAT

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.66798406
2L-phenylalanine catabolic process (GO:0006559)7.66798406
3L-phenylalanine metabolic process (GO:0006558)7.36364059
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.36364059
5aromatic amino acid family catabolic process (GO:0009074)6.87939604
6triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.49691602
7tryptophan catabolic process (GO:0006569)6.19487740
8indole-containing compound catabolic process (GO:0042436)6.19487740
9indolalkylamine catabolic process (GO:0046218)6.19487740
10kynurenine metabolic process (GO:0070189)6.06769501
11exogenous drug catabolic process (GO:0042738)5.96444050
12bile acid biosynthetic process (GO:0006699)5.95695366
13tryptophan metabolic process (GO:0006568)5.82649563
14glyoxylate metabolic process (GO:0046487)5.79960354
15urea cycle (GO:0000050)5.76351377
16urea metabolic process (GO:0019627)5.76351377
17high-density lipoprotein particle remodeling (GO:0034375)5.67950490
18negative regulation of fibrinolysis (GO:0051918)5.62740379
19alpha-linolenic acid metabolic process (GO:0036109)5.58406903
20regulation of fibrinolysis (GO:0051917)5.41669440
21cysteine metabolic process (GO:0006534)5.41605630
22sulfur amino acid catabolic process (GO:0000098)5.39615036
23peptidyl-glutamic acid carboxylation (GO:0017187)5.36814580
24protein carboxylation (GO:0018214)5.36814580
25nitrogen cycle metabolic process (GO:0071941)5.30115199
26serine family amino acid catabolic process (GO:0009071)5.26384829
27regulation of protein activation cascade (GO:2000257)5.25176573
28intestinal cholesterol absorption (GO:0030299)5.24567278
29complement activation, alternative pathway (GO:0006957)5.23235798
30bile acid metabolic process (GO:0008206)5.10955640
31epoxygenase P450 pathway (GO:0019373)5.07023624
32aromatic amino acid family metabolic process (GO:0009072)5.01999744
33regulation of cholesterol esterification (GO:0010872)4.97366925
34reverse cholesterol transport (GO:0043691)4.95343447
35regulation of triglyceride catabolic process (GO:0010896)4.92817374
36regulation of complement activation (GO:0030449)4.89239064
37fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.86059404
38tyrosine metabolic process (GO:0006570)4.85138224
39homocysteine metabolic process (GO:0050667)4.84308960
40plasma lipoprotein particle remodeling (GO:0034369)4.83749037
41protein-lipid complex remodeling (GO:0034368)4.83749037
42macromolecular complex remodeling (GO:0034367)4.83749037
43triglyceride homeostasis (GO:0070328)4.70702900
44acylglycerol homeostasis (GO:0055090)4.70702900
45alpha-amino acid catabolic process (GO:1901606)4.70273263
46negative regulation of sterol transport (GO:0032372)4.67847577
47negative regulation of cholesterol transport (GO:0032375)4.67847577
48phospholipid efflux (GO:0033700)4.67458745
49amino-acid betaine metabolic process (GO:0006577)4.66396141
50lysine catabolic process (GO:0006554)4.59188504
51lysine metabolic process (GO:0006553)4.59188504
52cellular ketone body metabolic process (GO:0046950)4.56926857
53glycine metabolic process (GO:0006544)4.54541724
54plasma lipoprotein particle clearance (GO:0034381)4.41656249
55imidazole-containing compound metabolic process (GO:0052803)4.41487664
56bile acid and bile salt transport (GO:0015721)4.40940294
57coenzyme catabolic process (GO:0009109)4.40601148
58indolalkylamine metabolic process (GO:0006586)4.38617310
59cellular amino acid catabolic process (GO:0009063)4.32597401
60amine catabolic process (GO:0009310)4.29760381
61cellular biogenic amine catabolic process (GO:0042402)4.29760381
62glutamate metabolic process (GO:0006536)4.28742999
63cholesterol efflux (GO:0033344)4.27535285
64omega-hydroxylase P450 pathway (GO:0097267)4.27139256
65serine family amino acid metabolic process (GO:0009069)4.26582888
66cellular glucuronidation (GO:0052695)4.24132066
67benzene-containing compound metabolic process (GO:0042537)4.12270033
68serine family amino acid biosynthetic process (GO:0009070)4.11732232
69ethanol oxidation (GO:0006069)4.08282392
70cellular modified amino acid catabolic process (GO:0042219)4.07508787
71intestinal absorption (GO:0050892)4.06844226
72dicarboxylic acid biosynthetic process (GO:0043650)4.04651353
73plasma lipoprotein particle assembly (GO:0034377)4.04276926
74drug metabolic process (GO:0017144)4.02774511
75aldehyde catabolic process (GO:0046185)4.02665553
76low-density lipoprotein particle remodeling (GO:0034374)4.01466752
77fibrinolysis (GO:0042730)3.99219082
78flavonoid metabolic process (GO:0009812)3.98896099
79ketone body metabolic process (GO:1902224)3.95603126
80oxidative demethylation (GO:0070989)3.92836198
81positive regulation of triglyceride lipase activity (GO:0061365)3.91737127
82positive regulation of lipoprotein lipase activity (GO:0051006)3.91737127
83drug catabolic process (GO:0042737)3.90441649
84blood coagulation, intrinsic pathway (GO:0007597)3.86072490
85cofactor catabolic process (GO:0051187)3.81781479
86regulation of bile acid biosynthetic process (GO:0070857)3.81368461
87negative regulation of lipase activity (GO:0060192)3.78337804
88organic acid catabolic process (GO:0016054)3.78015123
89carboxylic acid catabolic process (GO:0046395)3.78015123
90cholesterol homeostasis (GO:0042632)3.77855739
91protein-lipid complex subunit organization (GO:0071825)3.77763118
92very-low-density lipoprotein particle assembly (GO:0034379)3.76937552
93positive regulation of lipid catabolic process (GO:0050996)3.76101143
94glucuronate metabolic process (GO:0019585)3.75759522
95uronic acid metabolic process (GO:0006063)3.75759522
96complement activation, classical pathway (GO:0006958)3.73371745
97sterol homeostasis (GO:0055092)3.71698889
98phospholipid homeostasis (GO:0055091)3.69723301
99short-chain fatty acid metabolic process (GO:0046459)3.69338461
100complement activation (GO:0006956)3.68523747
101protein activation cascade (GO:0072376)3.68331261
102regulation of cholesterol homeostasis (GO:2000188)3.67190905
103plasma lipoprotein particle organization (GO:0071827)3.66829475
104* arginine metabolic process (GO:0006525)3.66081204
105acetyl-CoA metabolic process (GO:0006084)3.63565649
106NAD biosynthetic process (GO:0009435)3.62826954
107cytolysis (GO:0019835)3.62795846
108S-adenosylmethionine metabolic process (GO:0046500)3.62494489
109protein-lipid complex assembly (GO:0065005)3.61671531
110nicotinamide nucleotide biosynthetic process (GO:0019359)3.58365229
111drug transmembrane transport (GO:0006855)3.56764603
112regulation of plasminogen activation (GO:0010755)3.53921472
113negative regulation of protein activation cascade (GO:2000258)3.53326721
114ethanol metabolic process (GO:0006067)3.31895732
115lipoprotein metabolic process (GO:0042157)3.30263291
116regulation of humoral immune response (GO:0002920)3.16095159
117oxaloacetate metabolic process (GO:0006107)3.12730794
118proline metabolic process (GO:0006560)3.12575023
119acute-phase response (GO:0006953)3.12274718
120positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.11412239
121negative regulation of blood coagulation (GO:0030195)3.02281313
122negative regulation of hemostasis (GO:1900047)3.02281313
123peptidyl-glutamic acid modification (GO:0018200)3.01093450
124L-fucose catabolic process (GO:0042355)3.01077623
125fucose catabolic process (GO:0019317)3.01077623
126L-fucose metabolic process (GO:0042354)3.01077623
127cholesterol transport (GO:0030301)2.99296846
128sterol transport (GO:0015918)2.99296846

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse8.45886446
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse7.27126723
3EGR1_23403033_ChIP-Seq_LIVER_Mouse7.08962010
4LXR_22158963_ChIP-Seq_LIVER_Mouse6.53185698
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.33900322
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse5.20057148
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.90486169
8CEBPB_23403033_ChIP-Seq_LIVER_Mouse4.06679153
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse4.02759970
10ZNF274_21170338_ChIP-Seq_K562_Hela3.10220805
11CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.51277197
12GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.40212196
13VDR_22108803_ChIP-Seq_LS180_Human2.37354199
14FLI1_27457419_Chip-Seq_LIVER_Mouse2.34593103
15FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.13516682
16PCGF2_27294783_Chip-Seq_ESCs_Mouse2.09924658
17* HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.03895846
18* TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.01796071
19ESR1_17901129_ChIP-ChIP_LIVER_Mouse12.0854075
20PCGF2_27294783_Chip-Seq_NPCs_Mouse1.99649205
21TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.98692984
22GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.88666295
23HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.76273741
24FOXA2_19822575_ChIP-Seq_HepG2_Human1.58157074
25HTT_18923047_ChIP-ChIP_STHdh_Human1.56973019
26IGF1R_20145208_ChIP-Seq_DFB_Human1.54996540
27ER_23166858_ChIP-Seq_MCF-7_Human1.49612537
28EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.47876722
29CLOCK_20551151_ChIP-Seq_293T_Human1.47836336
30NOTCH1_21737748_ChIP-Seq_TLL_Human1.46159481
31* HNF4A_19822575_ChIP-Seq_HepG2_Human1.42029036
32GATA1_22025678_ChIP-Seq_K562_Human1.39243012
33FOXA1_27270436_Chip-Seq_PROSTATE_Human1.37236022
34FOXA1_25329375_ChIP-Seq_VCAP_Human1.37236022
35RAC3_21632823_ChIP-Seq_H3396_Human1.35646846
36NFE2_27457419_Chip-Seq_LIVER_Mouse1.34392575
37NANOG_20526341_ChIP-Seq_ESCs_Human1.31970210
38GBX2_23144817_ChIP-Seq_PC3_Human1.31659444
39SUZ12_27294783_Chip-Seq_NPCs_Mouse1.29855715
40OCT4_20526341_ChIP-Seq_ESCs_Human1.28178549
41IRF1_19129219_ChIP-ChIP_H3396_Human1.25514627
42MYC_19829295_ChIP-Seq_ESCs_Human1.25029699
43THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.24439339
44GATA3_21878914_ChIP-Seq_MCF-7_Human1.23311298
45RXRA_24833708_ChIP-Seq_LIVER_Mouse1.23058402
46SOX2_19829295_ChIP-Seq_ESCs_Human1.22725488
47NANOG_19829295_ChIP-Seq_ESCs_Human1.22725488
48STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.21163693
49EZH2_27294783_Chip-Seq_NPCs_Mouse1.16876221
50ETV2_25802403_ChIP-Seq_MESCs_Mouse1.16869303
51AR_21572438_ChIP-Seq_LNCaP_Human1.16847805
52HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.14620988
53* ERA_21632823_ChIP-Seq_H3396_Human1.13324055
54HOXB7_26014856_ChIP-Seq_BT474_Human1.13106661
55EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.11735577
56STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.11563838
57TP53_22573176_ChIP-Seq_HFKS_Human1.10404416
58POU3F2_20337985_ChIP-ChIP_501MEL_Human1.09535472
59* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.07047852
60GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.06783124
61ESR1_15608294_ChIP-ChIP_MCF-7_Human1.06411320
62ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.04092720
63EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.03836225
64CRX_20693478_ChIP-Seq_RETINA_Mouse1.03369398
65CDX2_22108803_ChIP-Seq_LS180_Human1.02859047
66IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.99370920
67SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.98813758
68CTBP1_25329375_ChIP-Seq_LNCAP_Human0.97653402
69FOXH1_21741376_ChIP-Seq_ESCs_Human0.97587045
70SRF_21415370_ChIP-Seq_HL-1_Mouse0.97380222
71TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.96625460
72TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.96028611
73E2F1_20622854_ChIP-Seq_HELA_Human0.95975792
74SOX2_27498859_Chip-Seq_STOMACH_Mouse0.94950641
75PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.94038424
76TCF4_22108803_ChIP-Seq_LS180_Human0.93576810
77FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.92436935
78LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.90143856
79UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.90092214
80FOXA1_21572438_ChIP-Seq_LNCaP_Human0.89082925
81GATA3_26560356_Chip-Seq_TH2_Human0.88632612
82ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.85897774
83STAT3_18555785_Chip-Seq_ESCs_Mouse0.85860217
84STAT3_23295773_ChIP-Seq_U87_Human0.85821074
85AUTS2_25519132_ChIP-Seq_293T-REX_Human0.85566224
86ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.84847744
87KAP1_22055183_ChIP-Seq_ESCs_Mouse0.84327798
88IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.84257122
89CBP_20019798_ChIP-Seq_JUKART_Human0.84257122
90GATA4_25053715_ChIP-Seq_YYC3_Human0.83946219
91EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.82974422
92SMAD4_21741376_ChIP-Seq_EPCs_Human0.82818220
93OCT4_18555785_Chip-Seq_ESCs_Mouse0.82733497
94PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.82342195
95ZFP57_27257070_Chip-Seq_ESCs_Mouse0.82104175
96TDRD3_21172665_ChIP-Seq_MCF-7_Human0.81109060
97SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.80664976
98RARG_19884340_ChIP-ChIP_MEFs_Mouse0.80213407
99IRF8_22096565_ChIP-ChIP_GC-B_Human0.79112651
100SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.78560063
101RARA_24833708_ChIP-Seq_LIVER_Mouse0.76071048
102ZNF263_19887448_ChIP-Seq_K562_Human0.73898137
103E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.70749152
104BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.69262572
105CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.68243146
106NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.66400815
107BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.64991897
108SALL4_18804426_ChIP-ChIP_XEN_Mouse0.64888639
109Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.64868253
110AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.64395944
111* RARB_24833708_ChIP-Seq_LIVER_Mouse0.64003079
112RAD21_21589869_ChIP-Seq_MESCs_Mouse0.63305778
113ESR2_21235772_ChIP-Seq_MCF-7_Human0.62244850
114RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.60765884
115NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.60638034
116NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.60160616
117CEBPB_22108803_ChIP-Seq_LS180_Human0.58739408
118STAT3_1855785_ChIP-Seq_MESCs_Mouse0.58067382
119NRF2_20460467_ChIP-Seq_MEFs_Mouse0.57840010
120NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.57840010
121AR_20517297_ChIP-Seq_VCAP_Human0.52990020
122FOXA1_25552417_ChIP-Seq_VCAP_Human0.52165883
123LXR_22292898_ChIP-Seq_THP-1_Human0.52079915
124MYC_19915707_ChIP-ChIP_AK7_Human0.52038455
125EGR1_19032775_ChIP-ChIP_M12_Human0.50632047
126FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.50582912
127* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.50133160
128FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.49864001
129ESET_19884257_ChIP-Seq_ESCs_Mouse0.49597332
130STAT1_17558387_ChIP-Seq_HELA_Human0.48798638
131P53_21459846_ChIP-Seq_SAOS-2_Human0.48486092
132CBP_21632823_ChIP-Seq_H3396_Human0.47827456
133CDX2_20551321_ChIP-Seq_CACO-2_Human0.46923234
134PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.46374748
135PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.44454562
136* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.44448198
137TAF2_19829295_ChIP-Seq_ESCs_Human0.44301253
138SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.42487337
139GATA6_25053715_ChIP-Seq_YYC3_Human0.41876264
140FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.41395396
141CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.39509913
142ERG_21242973_ChIP-ChIP_JURKAT_Human0.39193023
143ESR1_21235772_ChIP-Seq_MCF-7_Human0.39141486
144STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.39032303
145GATA1_19941826_ChIP-Seq_K562_Human0.38663158
146FOXO3_23340844_ChIP-Seq_DLD1_Human0.38233061
147* GATA1_19941827_ChIP-Seq_MEL_Mouse0.38058943
148PPAR_26484153_Chip-Seq_NCI-H1993_Human0.37025323
149GATA2_19941826_ChIP-Seq_K562_Human0.36791370
150LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.36512719
151CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.36427143
152SPI1_26923725_Chip-Seq_HPCs_Mouse0.36193369
153SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.35855403
154NCOR_22424771_ChIP-Seq_293T_Human0.35388709
155* MYC_27129775_Chip-Seq_CORNEA_Mouse0.35269732
156BCAT_22108803_ChIP-Seq_LS180_Human0.35183306
157SOX3_22085726_ChIP-Seq_MUSCLE_Mouse0.34818595
158FOXH1_21741376_ChIP-Seq_EPCs_Human0.34545572
159TAF15_26573619_Chip-Seq_HEK293_Human0.34473346
160SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.33121601
161ERG_20517297_ChIP-Seq_VCAP_Human0.32960586
162BCOR_27268052_Chip-Seq_Bcells_Human0.32741598

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.36392612
2MP0005360_urolithiasis7.59055845
3MP0005085_abnormal_gallbladder_physiolo6.46493804
4MP0005365_abnormal_bile_salt6.18997334
5MP0008875_abnormal_xenobiotic_pharmacok5.11929143
6MP0003806_abnormal_nucleotide_metabolis4.32549765
7MP0003252_abnormal_bile_duct3.90811463
8MP0010329_abnormal_lipoprotein_level3.60761500
9MP0009840_abnormal_foam_cell3.38990515
10MP0005083_abnormal_biliary_tract3.03727109
11MP0003195_calcinosis2.84974500
12MP0005332_abnormal_amino_acid2.79672485
13MP0003646_muscle_fatigue2.69934928
14MP0001666_abnormal_nutrient_absorption2.62168411
15MP0003191_abnormal_cellular_cholesterol2.32838145
16MP0004019_abnormal_vitamin_homeostasis2.15946716
17MP0000609_abnormal_liver_physiology2.15901197
18MP0002118_abnormal_lipid_homeostasis2.09702699
19MP0002138_abnormal_hepatobiliary_system1.96756835
20MP0004145_abnormal_muscle_electrophysio1.91727416
21MP0003868_abnormal_feces_composition1.90938302
22MP0004043_abnormal_pH_regulation1.87052817
23MP0005319_abnormal_enzyme/_coenzyme1.83154290
24MP0001764_abnormal_homeostasis1.71428551
25MP0009697_abnormal_copulation1.65307274
26MP0005584_abnormal_enzyme/coenzyme_acti1.56999081
27MP0005451_abnormal_body_composition1.56828011
28MP0003011_delayed_dark_adaptation1.39569843
29MP0003122_maternal_imprinting1.38308564
30MP0003186_abnormal_redox_activity1.28855775
31MP0003656_abnormal_erythrocyte_physiolo1.28264195
32MP0009643_abnormal_urine_homeostasis1.23571988
33MP0004147_increased_porphyrin_level1.20605030
34MP0000598_abnormal_liver_morphology1.16816960
35MP0005551_abnormal_eye_electrophysiolog1.15641057
36MP0005647_abnormal_sex_gland1.13911894
37MP0003705_abnormal_hypodermis_morpholog1.12560881
38MP0001873_stomach_inflammation1.09061450
39MP0000604_amyloidosis1.07418545
40MP0003183_abnormal_peptide_metabolism1.07148255
41MP0009764_decreased_sensitivity_to1.03292217
42MP0009763_increased_sensitivity_to1.00414126
43MP0005167_abnormal_blood-brain_barrier0.99532799
44MP0002254_reproductive_system_inflammat0.99267428
45MP0005636_abnormal_mineral_homeostasis0.92416356
46MP0010368_abnormal_lymphatic_system0.90474990
47MP0009780_abnormal_chondrocyte_physiolo0.90063489
48MP0002638_abnormal_pupillary_reflex0.89022689
49MP0001986_abnormal_taste_sensitivity0.88356114
50MP0001765_abnormal_ion_homeostasis0.88006477
51MP0008469_abnormal_protein_level0.87428539
52MP0009642_abnormal_blood_homeostasis0.86967025
53MP0006036_abnormal_mitochondrial_physio0.86810608
54MP0005408_hypopigmentation0.85799818
55MP0004142_abnormal_muscle_tone0.81603716
56MP0005376_homeostasis/metabolism_phenot0.80370795
57MP0009333_abnormal_splenocyte_physiolog0.79482872
58MP0002876_abnormal_thyroid_physiology0.78636405
59MP0003879_abnormal_hair_cell0.77630901
60MP0005645_abnormal_hypothalamus_physiol0.77541346
61MP0002078_abnormal_glucose_homeostasis0.76732461
62MP0009765_abnormal_xenobiotic_induced0.76412875
63MP0005084_abnormal_gallbladder_morpholo0.75815709
64MP0002938_white_spotting0.72746115
65MP0003567_abnormal_fetal_cardiomyocyte0.72111870
66MP0005670_abnormal_white_adipose0.71878423
67MP0005410_abnormal_fertilization0.70191933
68MP0005220_abnormal_exocrine_pancreas0.70000754
69MP0002971_abnormal_brown_adipose0.69924173
70MP0005334_abnormal_fat_pad0.67490828
71MP0002089_abnormal_postnatal_growth/wei0.66349394
72MP0001661_extended_life_span0.66180929
73MP0009053_abnormal_anal_canal0.65833126
74MP0005266_abnormal_metabolism0.65616306
75MP0005535_abnormal_body_temperature0.65573937
76MP0002106_abnormal_muscle_physiology0.65411672
77MP0004130_abnormal_muscle_cell0.64697859
78MP0002102_abnormal_ear_morphology0.63820913
79MP0002693_abnormal_pancreas_physiology0.63581451
80MP0003690_abnormal_glial_cell0.63479433
81MP0000566_synostosis0.62365828
82MP0003329_amyloid_beta_deposits0.62183338
83MP0005379_endocrine/exocrine_gland_phen0.59875625
84MP0000639_abnormal_adrenal_gland0.59466571
85MP0006035_abnormal_mitochondrial_morpho0.59448732
86MP0001756_abnormal_urination0.59380147
87MP0002160_abnormal_reproductive_system0.57662104
88MP0000013_abnormal_adipose_tissue0.56708765
89MP0000685_abnormal_immune_system0.56105361
90MP0005448_abnormal_energy_balance0.55664661
91MP0005389_reproductive_system_phenotype0.55476076
92MP0003718_maternal_effect0.55016125
93MP0004742_abnormal_vestibular_system0.54753424
94MP0002822_catalepsy0.53213712
95MP0003136_yellow_coat_color0.51581879
96MP0005395_other_phenotype0.51255040
97MP0002163_abnormal_gland_morphology0.50618197
98MP0005646_abnormal_pituitary_gland0.50478433
99MP0005464_abnormal_platelet_physiology0.49942648
100MP0005369_muscle_phenotype0.48689451
101MP0002269_muscular_atrophy0.48456930
102MP0008877_abnormal_DNA_methylation0.47842405
103MP0001324_abnormal_eye_pigmentation0.47686569
104MP0002909_abnormal_adrenal_gland0.47556820
105MP0000371_diluted_coat_color0.47347464
106MP0003950_abnormal_plasma_membrane0.47088460
107MP0000538_abnormal_urinary_bladder0.45490755
108MP0003638_abnormal_response/metabolism_0.45394615
109MP0001485_abnormal_pinna_reflex0.44984402
110MP0008874_decreased_physiological_sensi0.44425889
111MP0002136_abnormal_kidney_physiology0.44376572
112MP0004782_abnormal_surfactant_physiolog0.44202352
113MP0008873_increased_physiological_sensi0.43664570
114MP0008961_abnormal_basal_metabolism0.43643367
115MP0000372_irregular_coat_pigmentation0.42994558
116MP0003943_abnormal_hepatobiliary_system0.42932976
117MP0002928_abnormal_bile_duct0.42643078
118MP0008872_abnormal_physiological_respon0.41576141
119MP0001968_abnormal_touch/_nociception0.41250833
120MP0003953_abnormal_hormone_level0.40879084
121MP0002837_dystrophic_cardiac_calcinosis0.40424842
122MP0005248_abnormal_Harderian_gland0.39405416
123MP0003724_increased_susceptibility_to0.38736586
124MP0003436_decreased_susceptibility_to0.37621199
125MP0009672_abnormal_birth_weight0.37552213
126MP0005166_decreased_susceptibility_to0.37451571
127MP0003075_altered_response_to0.37240092
128MP0005666_abnormal_adipose_tissue0.35964816
129MP0004381_abnormal_hair_follicle0.35367964
130MP0006082_CNS_inflammation0.32630346
131MP0009115_abnormal_fat_cell0.32402582
132MP0002796_impaired_skin_barrier0.32377719
133MP0000579_abnormal_nail_morphology0.32225452
134MP0000249_abnormal_blood_vessel0.31476545
135MP0000230_abnormal_systemic_arterial0.31143162
136MP0001243_abnormal_dermal_layer0.30533228
137MP0004883_abnormal_blood_vessel0.30295160
138MP0002168_other_aberrant_phenotype0.29207535
139MP0002970_abnormal_white_adipose0.28816179
140MP0002132_abnormal_respiratory_system0.28701106
141MP0001853_heart_inflammation0.27401414
142MP0001845_abnormal_inflammatory_respons0.27259777
143MP0001881_abnormal_mammary_gland0.26821739
144MP0009384_cardiac_valve_regurgitation0.24656397
145MP0005164_abnormal_response_to0.22245606
146MP0002060_abnormal_skin_morphology0.22227411
147MP0005058_abnormal_lysosome_morphology0.21663164

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)7.52444524
2Deep venous thrombosis (HP:0002625)7.38343046
3Intrahepatic cholestasis (HP:0001406)7.27281457
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.74071508
5Prolonged partial thromboplastin time (HP:0003645)6.51724646
6Hypobetalipoproteinemia (HP:0003563)6.47755177
7Xanthomatosis (HP:0000991)6.25730230
8Hyperlipoproteinemia (HP:0010980)5.63144179
9Complement deficiency (HP:0004431)5.21037672
10Hypolipoproteinemia (HP:0010981)4.81635605
11Joint hemorrhage (HP:0005261)4.75996063
12Hyperammonemia (HP:0001987)4.68675266
13Hyperglycinemia (HP:0002154)4.57098459
14Epidermoid cyst (HP:0200040)4.41592012
15Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.38959151
16Abnormality of the common coagulation pathway (HP:0010990)4.38096032
17Abnormality of methionine metabolism (HP:0010901)4.33328388
18Abnormality of sulfur amino acid metabolism (HP:0004339)4.28597239
19Ketosis (HP:0001946)4.25466322
20Hypoalphalipoproteinemia (HP:0003233)4.19348618
21Abnormality of aspartate family amino acid metabolism (HP:0010899)4.15807513
22Abnormality of glutamine family amino acid metabolism (HP:0010902)4.14855275
23Fat malabsorption (HP:0002630)4.09753956
24Hyperglycinuria (HP:0003108)4.02183587
25Abnormality of glycine metabolism (HP:0010895)4.00019306
26Abnormality of serine family amino acid metabolism (HP:0010894)4.00019306
27Abnormality of pyrimidine metabolism (HP:0004353)3.91776026
28Hypoglycemic coma (HP:0001325)3.87230681
29Abnormality of complement system (HP:0005339)3.80025280
30Conjugated hyperbilirubinemia (HP:0002908)3.72353619
31Abnormality of the intrinsic pathway (HP:0010989)3.72284229
32Hypercholesterolemia (HP:0003124)3.58334291
33Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.41954674
34Abnormality of fatty-acid metabolism (HP:0004359)3.39909332
35Hyperbilirubinemia (HP:0002904)3.34638561
36Abnormality of serum amino acid levels (HP:0003112)3.19010431
37Delayed CNS myelination (HP:0002188)3.17152222
38Abnormality of nucleobase metabolism (HP:0010932)3.09002774
39Steatorrhea (HP:0002570)3.08511741
40Spontaneous abortion (HP:0005268)3.01531587
41Hepatocellular carcinoma (HP:0001402)2.99919241
42Ketoacidosis (HP:0001993)2.99155327
43Hypochromic microcytic anemia (HP:0004840)2.96126497
44Myocardial infarction (HP:0001658)2.90770607
45Metabolic acidosis (HP:0001942)2.81159211
46Muscle fiber inclusion bodies (HP:0100299)2.75833784
47Skin nodule (HP:0200036)2.71433005
48Lethargy (HP:0001254)2.69965500
49Abnormality of alanine metabolism (HP:0010916)2.69549736
50Hyperalaninemia (HP:0003348)2.69549736
51Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.69549736
52Bile duct proliferation (HP:0001408)2.69348445
53Abnormal biliary tract physiology (HP:0012439)2.69348445
54Facial shape deformation (HP:0011334)2.68304649
55Potter facies (HP:0002009)2.68304649
56Abnormality of purine metabolism (HP:0004352)2.67616148
57Abnormality of dicarboxylic acid metabolism (HP:0010995)2.66383034
58Dicarboxylic aciduria (HP:0003215)2.66383034
59Nemaline bodies (HP:0003798)2.66335288
60Systemic lupus erythematosus (HP:0002725)2.64371329
61Vascular calcification (HP:0004934)2.59376691
62Fair hair (HP:0002286)2.54747835
63Cerebral edema (HP:0002181)2.50466687
64Acanthocytosis (HP:0001927)2.49655658
65Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.46885730
66Gout (HP:0001997)2.46471074
67Spastic diplegia (HP:0001264)2.45561172
68Hypoglycemic seizures (HP:0002173)2.45195591
69Abnormal gallbladder morphology (HP:0012437)2.44386017
70Arthropathy (HP:0003040)2.42126031
71Glomerulonephritis (HP:0000099)2.39556096
72Cholelithiasis (HP:0001081)2.39385087
73Irritability (HP:0000737)2.38034999
74Mitral stenosis (HP:0001718)2.37931557
75Malnutrition (HP:0004395)2.36558399
76Neonatal onset (HP:0003623)2.34682516
77Pancreatic islet-cell hyperplasia (HP:0004510)2.33851701
78Abnormal urine output (HP:0012590)2.33102565
79Abnormality of the renal cortex (HP:0011035)2.32025120
80Abnormal gallbladder physiology (HP:0012438)2.30867492
81Cholecystitis (HP:0001082)2.30867492
82Pigmentary retinal degeneration (HP:0001146)2.30735471
83Cardiovascular calcification (HP:0011915)2.29443955
84Amyloidosis (HP:0011034)2.26104275
85Recurrent gram-negative bacterial infections (HP:0005420)2.24262590
86Hypothermia (HP:0002045)2.21630128
87Muscle hypertrophy of the lower extremities (HP:0008968)2.21375738
88Gingival bleeding (HP:0000225)2.19396499
89Esophageal varix (HP:0002040)2.16793630
90Brushfield spots (HP:0001088)2.15977020
91Menorrhagia (HP:0000132)2.15219020
92Pancreatitis (HP:0001733)2.14981665
93Sensorimotor neuropathy (HP:0007141)2.13329908
94Late onset (HP:0003584)2.12308998
95Vomiting (HP:0002013)2.11627849
96Enlarged kidneys (HP:0000105)2.07216312
97Generalized aminoaciduria (HP:0002909)2.05749574
98Hypomagnesemia (HP:0002917)2.05658353
99Thrombophlebitis (HP:0004418)2.05432319
100Opisthotonus (HP:0002179)2.05170072
101Calf muscle hypertrophy (HP:0008981)2.02852201
102Poikilocytosis (HP:0004447)2.02686651
103Abnormality of the gallbladder (HP:0005264)1.98953194
104Abnormality of renal excretion (HP:0011036)1.98741786
105Hemorrhage of the eye (HP:0011885)1.98009271
106Metabolic alkalosis (HP:0200114)1.97853951
107Nephritis (HP:0000123)1.97070350
108Hyperinsulinemic hypoglycemia (HP:0000825)1.96450267
109Pancreatic cysts (HP:0001737)1.95837874
110Abnormal drinking behavior (HP:0030082)1.95134961
111Polydipsia (HP:0001959)1.95134961
112Hyperphosphaturia (HP:0003109)1.95124582
113Rickets (HP:0002748)1.93948267
114Abnormality of the nasal septum (HP:0000419)1.90068462
115Abnormality of iron homeostasis (HP:0011031)1.89863986
116Polyuria (HP:0000103)1.88996792
117Exercise-induced muscle cramps (HP:0003710)1.88727862
118Abnormal cartilage morphology (HP:0002763)1.88556971
119Congenital stationary night blindness (HP:0007642)1.88471776
120Abnormality of transition element cation homeostasis (HP:0011030)1.87349799
121Hypophosphatemic rickets (HP:0004912)1.86883126
122Renal cortical cysts (HP:0000803)1.86351396
123Reduced antithrombin III activity (HP:0001976)1.84158585
124Abnormality of proline metabolism (HP:0010907)1.82840754
125Hydroxyprolinuria (HP:0003080)1.82840754
126Tubular atrophy (HP:0000092)1.82671047
127Elevated hepatic transaminases (HP:0002910)1.81965384
128Alkalosis (HP:0001948)1.81643540
129Exercise-induced myalgia (HP:0003738)1.81490187
130Status epilepticus (HP:0002133)1.81403015
131Proximal tubulopathy (HP:0000114)1.80815932
132Rhabdomyolysis (HP:0003201)1.79846613
133Hypokalemia (HP:0002900)1.78759834
134Increased circulating renin level (HP:0000848)1.78351053
135Abnormal enzyme/coenzyme activity (HP:0012379)1.77727132
136Abnormality of vitamin metabolism (HP:0100508)1.76797259
137Type II lissencephaly (HP:0007260)1.76340314
138Abnormality of urine glucose concentration (HP:0011016)1.74050769
139Glycosuria (HP:0003076)1.74050769
140Azoospermia (HP:0000027)1.73052589

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.52765678
2WNK44.86189224
3FGFR44.67527200
4SIK14.51373523
5ERN14.39056888
6OBSCN4.22587053
7TAOK33.10894156
8TLK12.92450746
9INSRR2.82737838
10ZAK2.82315779
11ERBB42.81710688
12STK392.75683335
13ADRBK22.75396061
14OXSR12.58535603
15PIK3CA2.54856524
16PHKG12.48045610
17PHKG22.48045610
18WNK32.42496610
19ACVR1B2.37687548
20BMPR1B2.36789023
21MAP2K42.33678706
22PKN22.29146407
23MST1R2.24851109
24TXK1.96534095
25MAPKAPK31.93354478
26FLT31.92058430
27MAPK111.88453335
28PIK3CG1.87336157
29TRIB31.79213623
30TYK21.65906135
31LATS11.62322079
32DAPK21.54318775
33ABL21.52019154
34PTK61.46388880
35NEK91.43274865
36FRK1.35684941
37KDR1.28112353
38FGFR21.26876583
39NUAK11.24365581
40NLK1.22351272
41JAK21.19767835
42PINK11.16524704
43STK38L1.16003787
44MAP4K21.14823809
45VRK11.13426999
46PRKAA21.12052857
47MAP3K71.10571062
48GRK61.08758082
49MAP2K31.06856101
50ERBB21.03583880
51TBK11.02450109
52ITK1.02241841
53TYRO30.98825317
54MAPK40.98689525
55MAP3K100.97653004
56MAP3K110.96809743
57PRKCZ0.94320647
58JAK10.93898539
59SIK20.93522254
60IRAK30.88571607
61MAP3K30.88528093
62MAP2K60.86410581
63CDK60.85962502
64MAPK150.85765574
65MAP3K140.85576868
66WNK10.85504627
67MET0.85434151
68NME10.85152065
69MUSK0.82078723
70MAP4K10.81419260
71CAMKK20.78955436
72MAP3K40.78540159
73TIE10.77498764
74NEK10.77084867
75MAPK120.76202642
76PRKACG0.75912543
77CAMK2G0.72454042
78EPHB10.70263804
79PRKAA10.66514071
80GSK3A0.66450731
81EEF2K0.66388939
82CSK0.66204138
83DYRK1B0.65151713
84EPHA30.63568781
85MAPK130.62864237
86PBK0.62343455
87IKBKB0.62125117
88RPS6KB10.58185884
89SGK30.57481770
90STK160.54450745
91RIPK10.54148357
92TRPM70.54053669
93PTK20.54022029
94MAPK70.53759891
95CSNK1G10.52719443
96CAMK1D0.52226955
97PDPK10.51725412
98FGFR10.51302445
99PRKACA0.50884113
100IKBKE0.50102139
101PRKCQ0.49949169
102TGFBR20.49614853
103GRK10.49507346
104CDK80.49377619
105SGK10.49360804
106CDK40.49121880
107CSF1R0.48714500
108TSSK60.47970241
109TAOK20.47586722
110EPHA40.47036127
111FGFR30.44900661
112ADRBK10.44846252
113MAP3K50.44086836
114CSNK1A10.41794491
115PRKCG0.41669404
116EIF2AK30.41049176
117NTRK30.41047265
118CHUK0.40858297
119BRSK20.40757243
120MAP2K10.40394418
121PRKCE0.40393897
122PRKG10.40381744
123SGK20.40158253
124IGF1R0.39612890
125VRK20.39535638
126PRKCI0.39112245
127RPS6KB20.38450372
128MAPKAPK50.38047299
129TEC0.37908799
130SYK0.37331517
131CSNK1D0.36196841
132RPS6KA50.36121151
133ICK0.34357070
134MAP3K130.33556695
135RET0.33517693
136MTOR0.33271597
137LCK0.32504864
138CSNK1E0.31773983
139CAMK40.30939991
140LATS20.30661935
141MAP2K20.30212704
142PDK10.29998895
143MAP3K60.29904876
144CSNK1G20.29519429
145PKN10.29313454
146CSNK1G30.29106557
147EGFR0.28187522
148PDK40.27883538
149PDK30.27883538
150SGK4940.27829894
151SGK2230.27829894
152CASK0.26864936
153PRKCA0.26443705
154IRAK20.25795186
155MAP3K10.23752923
156AKT30.23306594
157IRAK10.22046492
158CSNK1A1L0.19067245
159ABL10.17347817

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.50270298
2Nitrogen metabolism_Homo sapiens_hsa009103.56302743
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.37993882
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.37552810
5Arginine biosynthesis_Homo sapiens_hsa002203.09723003
6Complement and coagulation cascades_Homo sapiens_hsa046102.71225542
7Tryptophan metabolism_Homo sapiens_hsa003802.68699836
8Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.68685697
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.67503685
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.58564403
11Fatty acid degradation_Homo sapiens_hsa000712.49946872
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.40565998
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.27373719
14Butanoate metabolism_Homo sapiens_hsa006502.16815290
15Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.12590023
16Peroxisome_Homo sapiens_hsa041462.07209294
17Chemical carcinogenesis_Homo sapiens_hsa052041.94104521
18Propanoate metabolism_Homo sapiens_hsa006401.92795721
19Histidine metabolism_Homo sapiens_hsa003401.92764385
20Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.92414928
21Steroid hormone biosynthesis_Homo sapiens_hsa001401.91861765
22PPAR signaling pathway_Homo sapiens_hsa033201.84901377
23Drug metabolism - other enzymes_Homo sapiens_hsa009831.80017634
24Fatty acid metabolism_Homo sapiens_hsa012121.79773806
25Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.75615987
26beta-Alanine metabolism_Homo sapiens_hsa004101.72808078
27Staphylococcus aureus infection_Homo sapiens_hsa051501.71221595
28Retinol metabolism_Homo sapiens_hsa008301.71057291
29Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.68028187
30Caffeine metabolism_Homo sapiens_hsa002321.66778098
31Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.63973161
32Selenocompound metabolism_Homo sapiens_hsa004501.59105187
33Phenylalanine metabolism_Homo sapiens_hsa003601.55698761
34Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.53928505
352-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.52400589
36Bile secretion_Homo sapiens_hsa049761.48193004
37Tyrosine metabolism_Homo sapiens_hsa003501.44427425
38Pyruvate metabolism_Homo sapiens_hsa006201.37253152
39Cysteine and methionine metabolism_Homo sapiens_hsa002701.35908812
40Sulfur metabolism_Homo sapiens_hsa009201.35479138
41Fatty acid elongation_Homo sapiens_hsa000621.33684914
42Folate biosynthesis_Homo sapiens_hsa007901.27013775
43Starch and sucrose metabolism_Homo sapiens_hsa005001.25399296
44Biosynthesis of amino acids_Homo sapiens_hsa012301.22441205
45Fat digestion and absorption_Homo sapiens_hsa049751.18777238
46ABC transporters_Homo sapiens_hsa020101.17052354
47Steroid biosynthesis_Homo sapiens_hsa001001.16504733
48Carbon metabolism_Homo sapiens_hsa012001.14198905
49Cyanoamino acid metabolism_Homo sapiens_hsa004601.05300366
50Vitamin B6 metabolism_Homo sapiens_hsa007501.03927731
51Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.03018661
52Maturity onset diabetes of the young_Homo sapiens_hsa049501.01668834
53Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.00109649
54Sulfur relay system_Homo sapiens_hsa041220.97441567
55Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.89223797
56* Arginine and proline metabolism_Homo sapiens_hsa003300.86502130
57Vitamin digestion and absorption_Homo sapiens_hsa049770.86175504
58Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.83728322
59Lysine degradation_Homo sapiens_hsa003100.81173989
60One carbon pool by folate_Homo sapiens_hsa006700.80011201
61Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.69851095
62Glycerolipid metabolism_Homo sapiens_hsa005610.67844746
63Glutathione metabolism_Homo sapiens_hsa004800.66106146
64Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.66068921
65Pentose phosphate pathway_Homo sapiens_hsa000300.60324441
66Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.55606130
67Fatty acid biosynthesis_Homo sapiens_hsa000610.49266455
68Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.47853936
69* Metabolic pathways_Homo sapiens_hsa011000.47416764
70Mineral absorption_Homo sapiens_hsa049780.44886173
71Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.40113520
72Intestinal immune network for IgA production_Homo sapiens_hsa046720.35701022
73Phototransduction_Homo sapiens_hsa047440.35467964
74Prion diseases_Homo sapiens_hsa050200.32918003
75Primary immunodeficiency_Homo sapiens_hsa053400.29175598
76alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.26589503
77Galactose metabolism_Homo sapiens_hsa000520.26179751
78Fructose and mannose metabolism_Homo sapiens_hsa000510.26146147
79Linoleic acid metabolism_Homo sapiens_hsa005910.23790171
80Circadian rhythm_Homo sapiens_hsa047100.22884607
81Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.20649345
82Insulin resistance_Homo sapiens_hsa049310.20621980
83Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.20320743
84Adipocytokine signaling pathway_Homo sapiens_hsa049200.18675064
85Oxidative phosphorylation_Homo sapiens_hsa001900.18551850
86Glycerophospholipid metabolism_Homo sapiens_hsa005640.17127470
87Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.14448382
88Glucagon signaling pathway_Homo sapiens_hsa049220.07237840
89Autoimmune thyroid disease_Homo sapiens_hsa053200.07069554
90RNA polymerase_Homo sapiens_hsa030200.05261148
91Graft-versus-host disease_Homo sapiens_hsa053320.03718519
92Allograft rejection_Homo sapiens_hsa053300.03170553
93Asthma_Homo sapiens_hsa053100.02972371
94AMPK signaling pathway_Homo sapiens_hsa041520.00811018
95Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.00693003
96Bladder cancer_Homo sapiens_hsa05219-0.2535453
97Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.2496190
98Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.2465776
99Ether lipid metabolism_Homo sapiens_hsa00565-0.2396848
100Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.2194560
101Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.2108676
102Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.2102081
103Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1981347
104Renin-angiotensin system_Homo sapiens_hsa04614-0.1893148
105Hepatitis C_Homo sapiens_hsa05160-0.1809576
106Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1783667
107Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1688378
108African trypanosomiasis_Homo sapiens_hsa05143-0.1526466
109Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1519164
110Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1424675
111Insulin signaling pathway_Homo sapiens_hsa04910-0.1203043
112Regulation of autophagy_Homo sapiens_hsa04140-0.1155548
113Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.1134047
114Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0870408
115Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0465584

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