AGL

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the glycogen debrancher enzyme which is involved in glycogen degradation. This enzyme has two independent catalytic activities which occur at different sites on the protein: a 4-alpha-glucotransferase activity and a amylo-1,6-glucosidase activity. Mutations in this gene are associated with glycogen storage disease although a wide range of enzymatic and clinical variability occurs which may be due to tissue-specific alternative splicing. Alternatively spliced transcripts encoding different isoforms have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1muscle filament sliding (GO:0030049)7.57591725
2actin-myosin filament sliding (GO:0033275)7.57591725
3regulation of skeletal muscle contraction (GO:0014819)7.10016612
4sarcoplasmic reticulum calcium ion transport (GO:0070296)6.37517122
5actin-mediated cell contraction (GO:0070252)6.36257132
6carnitine shuttle (GO:0006853)6.29327743
7sarcomere organization (GO:0045214)6.11278635
8fatty acid transmembrane transport (GO:1902001)5.78068095
9positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)5.75009637
10skeletal muscle contraction (GO:0003009)5.61237448
11myofibril assembly (GO:0030239)5.56601021
12regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)5.47476732
13negative regulation of potassium ion transmembrane transporter activity (GO:1901017)5.40058898
14myotube cell development (GO:0014904)5.33133895
15plasma membrane repair (GO:0001778)5.21691789
16cardiac myofibril assembly (GO:0055003)4.97918727
17NADH metabolic process (GO:0006734)4.96345604
18skeletal muscle adaptation (GO:0043501)4.89308035
19striated muscle contraction (GO:0006941)4.82489312
20actin filament-based movement (GO:0030048)4.80874389
21response to stimulus involved in regulation of muscle adaptation (GO:0014874)4.76934406
22negative regulation of potassium ion transmembrane transport (GO:1901380)4.74115369
23carnitine transmembrane transport (GO:1902603)4.69182672
24regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)4.62911707
25muscle fiber development (GO:0048747)4.56939937
26regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)4.55241916
27tricarboxylic acid cycle (GO:0006099)4.52626589
28regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO4.45766836
29cardiac muscle contraction (GO:0060048)4.44919458
30skeletal muscle tissue regeneration (GO:0043403)4.41033909
31regulation of cell communication by electrical coupling (GO:0010649)4.36677343
32carnitine transport (GO:0015879)4.35097987
33amino-acid betaine transport (GO:0015838)4.35097987
34skeletal muscle tissue development (GO:0007519)4.34660428
35regulation of acyl-CoA biosynthetic process (GO:0050812)4.15603406
36actomyosin structure organization (GO:0031032)4.12567379
37regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)4.11416951
38creatine metabolic process (GO:0006600)4.10594800
392-oxoglutarate metabolic process (GO:0006103)4.09887788
40regulation of relaxation of muscle (GO:1901077)4.09791758
41muscle cell fate commitment (GO:0042693)4.08626244
42* glycogen catabolic process (GO:0005980)3.97646681
43lysine catabolic process (GO:0006554)3.97298058
44lysine metabolic process (GO:0006553)3.97298058
45cardiac muscle hypertrophy in response to stress (GO:0014898)3.92514863
46cardiac muscle adaptation (GO:0014887)3.92514863
47regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.88409223
48striated muscle cell development (GO:0055002)3.87996031
49cardiac muscle cell development (GO:0055013)3.83787145
50regulation of actin filament-based movement (GO:1903115)3.82776502
51regulation of sequestering of triglyceride (GO:0010889)3.81175871
52muscle cell cellular homeostasis (GO:0046716)3.80885482
53regulation of coenzyme metabolic process (GO:0051196)3.76257334
54regulation of cofactor metabolic process (GO:0051193)3.76257334
55positive regulation of myotube differentiation (GO:0010831)3.74653334
56gluconeogenesis (GO:0006094)3.71661436
57* glucan catabolic process (GO:0009251)3.71609050
58muscle contraction (GO:0006936)3.68602464
59cardiac muscle hypertrophy (GO:0003300)3.62530470
60fatty acid beta-oxidation (GO:0006635)3.62307884
61striated muscle adaptation (GO:0014888)3.61695884
62regulation of striated muscle contraction (GO:0006942)3.61015241
63regulation of skeletal muscle cell differentiation (GO:2001014)3.60354304
64fructose metabolic process (GO:0006000)3.58901317
65cardiac cell development (GO:0055006)3.58389575
66striated muscle hypertrophy (GO:0014897)3.57330210
67muscle structure development (GO:0061061)3.53487513
68muscle organ development (GO:0007517)3.52465384
69adult heart development (GO:0007512)3.52199364
70striated muscle atrophy (GO:0014891)3.51666491
71regulation of sarcomere organization (GO:0060297)3.50922072
72regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.50732794
73aspartate family amino acid catabolic process (GO:0009068)3.49714542
74IMP metabolic process (GO:0046040)3.49398689
75* cellular polysaccharide catabolic process (GO:0044247)3.49358500
76regulation of calcium ion transmembrane transporter activity (GO:1901019)3.48585076
77regulation of calcium ion transmembrane transport (GO:1903169)3.48585076
78regulation of fatty acid oxidation (GO:0046320)3.47371412
79muscle organ morphogenesis (GO:0048644)3.45980596
80ventricular cardiac muscle cell action potential (GO:0086005)3.44425212
81response to muscle activity (GO:0014850)3.43793758
82pyrimidine ribonucleoside catabolic process (GO:0046133)3.41669247
83muscle system process (GO:0003012)3.40988612
84regulation of membrane repolarization (GO:0060306)3.40549599
85regulation of the force of heart contraction (GO:0002026)3.38731853
86positive regulation of fatty acid beta-oxidation (GO:0032000)3.38633607
87relaxation of muscle (GO:0090075)3.35725773
88intracellular lipid transport (GO:0032365)3.33647659
89hexose biosynthetic process (GO:0019319)3.33444571
90response to inactivity (GO:0014854)3.33351946
91positive regulation of fatty acid oxidation (GO:0046321)3.31315407
92negative regulation of calcium ion transmembrane transport (GO:1903170)3.29809546
93negative regulation of calcium ion transmembrane transporter activity (GO:1901020)3.29809546
94muscle cell development (GO:0055001)3.28325175
95response to activity (GO:0014823)3.27514857
96* glycogen biosynthetic process (GO:0005978)3.26986018
97* glucan biosynthetic process (GO:0009250)3.26986018
98cardiac muscle tissue morphogenesis (GO:0055008)3.26594374
99oxaloacetate metabolic process (GO:0006107)3.24365926
100* polysaccharide catabolic process (GO:0000272)3.24302094
101quaternary ammonium group transport (GO:0015697)3.23386524
102myotube differentiation (GO:0014902)3.22869011
103muscle hypertrophy (GO:0014896)3.20771650
104short-chain fatty acid metabolic process (GO:0046459)3.20535638
105regulation of myoblast differentiation (GO:0045661)3.19149054
106branched-chain amino acid catabolic process (GO:0009083)3.19142220
107fatty acid oxidation (GO:0019395)3.18095251
108valine metabolic process (GO:0006573)3.17995477
109heart process (GO:0003015)3.17051806
110heart contraction (GO:0060047)3.17051806
111regulation of sulfur metabolic process (GO:0042762)3.17017884
112acetyl-CoA metabolic process (GO:0006084)3.16759850
113fatty acid catabolic process (GO:0009062)3.15512054
114lipid oxidation (GO:0034440)3.15009794
115cellular ketone body metabolic process (GO:0046950)3.14539963
116myoblast fusion (GO:0007520)3.14009924
117* glycogen metabolic process (GO:0005977)3.13369094
118striated muscle tissue development (GO:0014706)3.10611991
119fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.10025534
120cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.09332314
121muscle tissue morphogenesis (GO:0060415)3.08947600
122succinate metabolic process (GO:0006105)3.08298531
123* cellular glucan metabolic process (GO:0006073)3.07326831
124* glucan metabolic process (GO:0044042)3.07326831
125muscle atrophy (GO:0014889)3.06428679
126positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.02066095
127biotin metabolic process (GO:0006768)3.00855117
128muscle adaptation (GO:0043500)2.99935194
129carnitine metabolic process (GO:0009437)2.99627057
130branched-chain amino acid metabolic process (GO:0009081)2.98232532
131skeletal muscle fiber development (GO:0048741)2.96859140
132bundle of His cell to Purkinje myocyte communication (GO:0086069)2.95780396
133muscle hypertrophy in response to stress (GO:0003299)2.93860965

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.52704438
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.24587560
3RXR_22158963_ChIP-Seq_LIVER_Mouse3.89880767
4PPARA_22158963_ChIP-Seq_LIVER_Mouse3.44381788
5LXR_22158963_ChIP-Seq_LIVER_Mouse3.41634314
6BP1_19119308_ChIP-ChIP_Hs578T_Human3.13255693
7NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.05494073
8TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.01995923
9ESR1_20079471_ChIP-ChIP_T-47D_Human2.76344282
10FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.72314615
11EP300_21415370_ChIP-Seq_HL-1_Mouse2.57161546
12RBPJ_22232070_ChIP-Seq_NCS_Mouse2.40438770
13CDX2_19796622_ChIP-Seq_MESCs_Mouse2.38715323
14* ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.38348135
15TBX20_22328084_ChIP-Seq_HEART_Mouse2.32461073
16TBX20_22080862_ChIP-Seq_HEART_Mouse2.32461073
17EGR1_23403033_ChIP-Seq_LIVER_Mouse2.32026441
18E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.99141969
19PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.90085939
20BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.83296949
21WT1_19549856_ChIP-ChIP_CCG9911_Human1.78468275
22RARG_19884340_ChIP-ChIP_MEFs_Mouse1.71916509
23BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.69898705
24FLI1_27457419_Chip-Seq_LIVER_Mouse1.60056271
25IGF1R_20145208_ChIP-Seq_DFB_Human1.60021037
26HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.59053042
27MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.57184044
28SALL1_21062744_ChIP-ChIP_HESCs_Human1.56440704
29* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.55469438
30EZH2_27294783_Chip-Seq_NPCs_Mouse1.55217491
31SALL4_18804426_ChIP-ChIP_XEN_Mouse1.54346138
32CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.53630143
33PCGF2_27294783_Chip-Seq_ESCs_Mouse1.47649026
34THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.45055950
35ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.42626037
36ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.42314977
37RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.41356332
38CRX_20693478_ChIP-Seq_RETINA_Mouse1.40954755
39FOXA2_19822575_ChIP-Seq_HepG2_Human1.39402419
40CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.36986679
41CLOCK_20551151_ChIP-Seq_293T_Human1.28250624
42OCT4_21477851_ChIP-Seq_ESCs_Mouse1.26153452
43EOMES_21245162_ChIP-Seq_HESCs_Human1.25584140
44ESR2_21235772_ChIP-Seq_MCF-7_Human1.24632114
45* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.20764372
46* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.20764372
47DROSHA_22980978_ChIP-Seq_HELA_Human1.20623902
48TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.20080386
49FOXM1_26456572_ChIP-Seq_MCF-7_Human1.18792228
50FUS_26573619_Chip-Seq_HEK293_Human1.18781908
51TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.18110066
52EZH2_22144423_ChIP-Seq_EOC_Human1.17466501
53AR_21572438_ChIP-Seq_LNCaP_Human1.16730069
54RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.16597823
55KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.14742068
56GATA4_21415370_ChIP-Seq_HL-1_Mouse1.14688451
57TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.13446085
58PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.11135140
59NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.10490131
60CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.10176858
61ZNF263_19887448_ChIP-Seq_K562_Human1.09730100
62ESR1_21235772_ChIP-Seq_MCF-7_Human1.07901572
63NFIB_24661679_ChIP-Seq_LUNG_Mouse1.07788866
64KLF5_20875108_ChIP-Seq_MESCs_Mouse1.06743440
65BCAT_22108803_ChIP-Seq_LS180_Human1.06669704
66NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.06198926
67PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.04396523
68TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.00945400
69TCF4_18268006_ChIP-ChIP_LS174T_Human1.00693677
70SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.00557301
71PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.00160868
72GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99775729
73PIAS1_25552417_ChIP-Seq_VCAP_Human0.99354972
74* SOX2_21211035_ChIP-Seq_LN229_Gbm0.99074793
75HTT_18923047_ChIP-ChIP_STHdh_Human0.98895737
76* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.98777776
77CJUN_26792858_Chip-Seq_BT549_Human0.96530906
78PPAR_26484153_Chip-Seq_NCI-H1993_Human0.96476069
79AUTS2_25519132_ChIP-Seq_293T-REX_Human0.96395917
80GBX2_23144817_ChIP-Seq_PC3_Human0.96354185
81STAT3_1855785_ChIP-Seq_MESCs_Mouse0.95870835
82SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.95006351
83AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.94824738
84TOP2B_26459242_ChIP-Seq_MCF-7_Human0.94511604
85SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.94464931
86MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.94248348
87FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.93744516
88* SMAD3_21741376_ChIP-Seq_EPCs_Human0.93195956
89NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.92545757
90* GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.91899822
91* PHF8_20622853_ChIP-Seq_HELA_Human0.91466776
92* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.91276195
93* CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.91200800
94MTF2_20144788_ChIP-Seq_MESCs_Mouse0.90463535
95ZFP57_27257070_Chip-Seq_ESCs_Mouse0.90391293
96TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.88999728
97PCGF2_27294783_Chip-Seq_NPCs_Mouse0.88937669
98RNF2_18974828_ChIP-Seq_MESCs_Mouse0.86936023
99EZH2_18974828_ChIP-Seq_MESCs_Mouse0.86936023
100PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.86720539
101E2F1_18555785_Chip-Seq_ESCs_Mouse0.86424580
102* SMAD4_21741376_ChIP-Seq_HESCs_Human0.86373284
103ER_23166858_ChIP-Seq_MCF-7_Human0.86284431
104P53_22127205_ChIP-Seq_FIBROBLAST_Human0.86257379
105GATA1_22025678_ChIP-Seq_K562_Human0.85989013
106NFE2_27457419_Chip-Seq_LIVER_Mouse0.85529779
107NR3C1_23031785_ChIP-Seq_PC12_Mouse0.85254117
108ZNF274_21170338_ChIP-Seq_K562_Hela0.85061362
109EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.84607880
110NR3C1_21868756_ChIP-Seq_MCF10A_Human0.84072153
111NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.83964608
112EZH2_27294783_Chip-Seq_ESCs_Mouse0.83653324
113CBP_21632823_ChIP-Seq_H3396_Human0.82077274
114ZNF217_24962896_ChIP-Seq_MCF-7_Human0.81320304
115SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.80731565
116SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.80585745
117CTCF_27219007_Chip-Seq_Bcells_Human0.80040256
118EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.79538667
119SMAD4_21799915_ChIP-Seq_A2780_Human0.79090809
120HNF4A_19822575_ChIP-Seq_HepG2_Human0.78684781
121ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.78178625
122ISL1_27105846_Chip-Seq_CPCs_Mouse0.77179213
123TP53_16413492_ChIP-PET_HCT116_Human0.76611308
124SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.76258248
125CTNNB1_20460455_ChIP-Seq_HCT116_Human0.75791344
126CBP_20019798_ChIP-Seq_JUKART_Human0.75587608
127IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.75587608
128TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.75445897
129PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.74622609
130SMAD3_21741376_ChIP-Seq_HESCs_Human0.74572953
131SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.73731887
132* CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.73706684
133AR_19668381_ChIP-Seq_PC3_Human0.73640199
134TRIM28_21343339_ChIP-Seq_HEK293_Human0.71276037
135OCT4_20526341_ChIP-Seq_ESCs_Human0.70988485
136PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.69021386
137AHR_22903824_ChIP-Seq_MCF-7_Human0.68323132
138UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.68311453
139* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.68306929
140AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.68105042
141* SOX9_24532713_ChIP-Seq_HFSC_Mouse0.67664990
142SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.67050772
143SUZ12_27294783_Chip-Seq_NPCs_Mouse0.66441184
144CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.66416076
145MYC_27129775_Chip-Seq_CORNEA_Mouse0.66090088
146SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.66034866

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003646_muscle_fatigue5.43529933
2MP0002837_dystrophic_cardiac_calcinosis5.17534671
3MP0000751_myopathy4.86966691
4MP0004145_abnormal_muscle_electrophysio4.71093152
5MP0000749_muscle_degeneration4.69044217
6MP0004036_abnormal_muscle_relaxation3.97824419
7MP0004084_abnormal_cardiac_muscle3.61438509
8MP0004130_abnormal_muscle_cell3.30286084
9MP0004215_abnormal_myocardial_fiber3.13455394
10MP0002106_abnormal_muscle_physiology3.06587686
11MP0004087_abnormal_muscle_fiber3.05424557
12MP0000747_muscle_weakness2.91140435
13MP0005330_cardiomyopathy2.89924830
14MP0005620_abnormal_muscle_contractility2.84828501
15MP0002269_muscular_atrophy2.81912212
16MP0000750_abnormal_muscle_regeneration2.69096475
17MP0000759_abnormal_skeletal_muscle2.59923023
18MP0002139_abnormal_hepatobiliary_system2.55627025
19MP0005369_muscle_phenotype2.55360793
20MP0005085_abnormal_gallbladder_physiolo2.25509489
21MP0002972_abnormal_cardiac_muscle2.25412282
22MP0005360_urolithiasis2.05473189
23MP0004233_abnormal_muscle_weight1.98578457
24MP0003137_abnormal_impulse_conducting1.94155254
25MP0010630_abnormal_cardiac_muscle1.85858513
26MP0008775_abnormal_heart_ventricle1.84881614
27MP0006036_abnormal_mitochondrial_physio1.83986436
28MP0005365_abnormal_bile_salt1.82709496
29MP0002332_abnormal_exercise_endurance1.80376699
30MP0003806_abnormal_nucleotide_metabolis1.73178777
31MP0001544_abnormal_cardiovascular_syste1.70447600
32MP0005385_cardiovascular_system_phenoty1.70447600
33MP0005670_abnormal_white_adipose1.69650054
34MP0004484_altered_response_of1.67531152
35MP0005666_abnormal_adipose_tissue1.62080839
36MP0002108_abnormal_muscle_morphology1.45506881
37MP0003252_abnormal_bile_duct1.44875888
38MP0003195_calcinosis1.44792681
39MP0006138_congestive_heart_failure1.36105633
40MP0002971_abnormal_brown_adipose1.32137793
41MP0010329_abnormal_lipoprotein_level1.31616490
42MP0003950_abnormal_plasma_membrane1.29313209
43MP0004085_abnormal_heartbeat1.25867747
44MP0003221_abnormal_cardiomyocyte_apopto1.25466434
45MP0000733_abnormal_muscle_development1.24553473
46MP0004185_abnormal_adipocyte_glucose1.21950579
47MP0005083_abnormal_biliary_tract1.19458190
48MP0008875_abnormal_xenobiotic_pharmacok1.18694163
49MP0003890_abnormal_embryonic-extraembry1.15003904
50MP0002127_abnormal_cardiovascular_syste1.13812290
51MP0005332_abnormal_amino_acid1.11729633
52MP0009840_abnormal_foam_cell1.10647672
53MP0006035_abnormal_mitochondrial_morpho1.06845554
54MP0002118_abnormal_lipid_homeostasis1.04821861
55MP0005375_adipose_tissue_phenotype1.01383286
56MP0003828_pulmonary_edema0.97578571
57MP0005266_abnormal_metabolism0.96347487
58MP0005319_abnormal_enzyme/_coenzyme0.96166417
59MP0002078_abnormal_glucose_homeostasis0.93612533
60MP0003705_abnormal_hypodermis_morpholog0.93055582
61MP0004510_myositis0.92432675
62MP0004043_abnormal_pH_regulation0.87449954
63MP0003941_abnormal_skin_development0.86417087
64MP0005334_abnormal_fat_pad0.83977087
65MP0005584_abnormal_enzyme/coenzyme_acti0.80527800
66MP0000266_abnormal_heart_morphology0.77286115
67MP0010030_abnormal_orbit_morphology0.75864154
68MP0002822_catalepsy0.75567637
69MP0000343_altered_response_to0.74217629
70MP0005187_abnormal_penis_morphology0.73254729
71MP0000372_irregular_coat_pigmentation0.72538866
72MP0005451_abnormal_body_composition0.72515749
73MP0000609_abnormal_liver_physiology0.71465638
74MP0005535_abnormal_body_temperature0.70768073
75MP0008438_abnormal_cutaneous_collagen0.68264074
76MP0000230_abnormal_systemic_arterial0.67822563
77MP0010368_abnormal_lymphatic_system0.66697671
78MP0002234_abnormal_pharynx_morphology0.62409542
79MP0003567_abnormal_fetal_cardiomyocyte0.61200509
80MP0000013_abnormal_adipose_tissue0.61099487
81MP0003279_aneurysm0.60713729
82MP0000762_abnormal_tongue_morphology0.59865278
83MP0005275_abnormal_skin_tensile0.59425836
84MP0005165_increased_susceptibility_to0.59038369
85MP0009780_abnormal_chondrocyte_physiolo0.54886665
86MP0002128_abnormal_blood_circulation0.54240384
87MP0009115_abnormal_fat_cell0.54113654
88MP0009384_cardiac_valve_regurgitation0.53877854
89MP0003656_abnormal_erythrocyte_physiolo0.53749297
90MP0009697_abnormal_copulation0.53333239
91MP0001666_abnormal_nutrient_absorption0.51550642
92MP0003045_fibrosis0.48909658
93MP0004134_abnormal_chest_morphology0.48893903
94MP0003191_abnormal_cellular_cholesterol0.47923769
95MP0000003_abnormal_adipose_tissue0.46891219
96MP0004147_increased_porphyrin_level0.41977708
97MP0003385_abnormal_body_wall0.41593276
98MP0002114_abnormal_axial_skeleton0.41385871
99MP0008961_abnormal_basal_metabolism0.40847135
100MP0001984_abnormal_olfaction0.40610779
101MP0005376_homeostasis/metabolism_phenot0.39905020
102MP0003690_abnormal_glial_cell0.39761225
103MP0009250_abnormal_appendicular_skeleto0.39463172
104MP0001299_abnormal_eye_distance/0.37775144
105MP0003984_embryonic_growth_retardation0.36975139
106MP0009643_abnormal_urine_homeostasis0.36682331
107MP0003868_abnormal_feces_composition0.36648257
108MP0002088_abnormal_embryonic_growth/wei0.36530813
109MP0005452_abnormal_adipose_tissue0.35803082
110MP0001346_abnormal_lacrimal_gland0.35792904
111MP0000579_abnormal_nail_morphology0.35494782
112MP0009703_decreased_birth_body0.34454240
113MP0004197_abnormal_fetal_growth/weight/0.33374204
114MP0001661_extended_life_span0.33185738
115MP0004270_analgesia0.32620246
116MP0002009_preneoplasia0.32150601
117MP0005448_abnormal_energy_balance0.31703202
118MP0001730_embryonic_growth_arrest0.30973431
119MP0009672_abnormal_birth_weight0.30690984
120MP0004272_abnormal_basement_membrane0.30542270
121MP0001672_abnormal_embryogenesis/_devel0.28008537
122MP0005380_embryogenesis_phenotype0.28008537
123MP0002638_abnormal_pupillary_reflex0.25232168
124MP0002896_abnormal_bone_mineralization0.24948820
125MP0003948_abnormal_gas_homeostasis0.24107425
126MP0008057_abnormal_DNA_replication0.23334632
127MP0002925_abnormal_cardiovascular_devel0.22682457
128MP0008004_abnormal_stomach_pH0.21057818
129MP0001943_abnormal_respiration0.19726941

Predicted human phenotypes

RankGene SetZ-score
1Exercise-induced myalgia (HP:0003738)7.61042235
2Exercise-induced muscle cramps (HP:0003710)7.06746407
3Muscle fiber inclusion bodies (HP:0100299)6.47240271
4Muscle hypertrophy of the lower extremities (HP:0008968)6.31452472
5Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)6.27190100
6Calf muscle hypertrophy (HP:0008981)6.14013099
7Myoglobinuria (HP:0002913)5.66134336
8Nemaline bodies (HP:0003798)5.61371104
9Type 1 muscle fiber predominance (HP:0003803)5.32651763
10Sudden death (HP:0001699)5.25810005
11Muscle fiber splitting (HP:0003555)5.11982102
12Hyporeflexia of lower limbs (HP:0002600)4.82691987
13Distal arthrogryposis (HP:0005684)4.71547239
14Abnormality of the calf musculature (HP:0001430)4.63995780
15Difficulty running (HP:0009046)4.48418066
16Subaortic stenosis (HP:0001682)4.42426583
17Abnormality of the left ventricular outflow tract (HP:0011103)4.42426583
18Centrally nucleated skeletal muscle fibers (HP:0003687)4.41676323
19Rhabdomyolysis (HP:0003201)4.38626461
20EMG: myopathic abnormalities (HP:0003458)4.31506275
21Muscle stiffness (HP:0003552)3.96602947
22Increased connective tissue (HP:0009025)3.94095495
23Ventricular tachycardia (HP:0004756)3.88591750
24Round ear (HP:0100830)3.84697979
25Myopathic facies (HP:0002058)3.83506537
26Asymmetric septal hypertrophy (HP:0001670)3.78033952
27Myotonia (HP:0002486)3.59944233
28Ulnar deviation of the wrist (HP:0003049)3.46458257
29Lipoatrophy (HP:0100578)3.20398826
30Atrial fibrillation (HP:0005110)3.13986394
31Absent phalangeal crease (HP:0006109)3.01169234
32Hypoglycemic coma (HP:0001325)2.98388360
33Dilated cardiomyopathy (HP:0001644)2.91377767
34Abnormality of skeletal muscle fiber size (HP:0012084)2.90255400
35Right ventricular cardiomyopathy (HP:0011663)2.88258193
36Primary atrial arrhythmia (HP:0001692)2.87097308
37Ketoacidosis (HP:0001993)2.84980212
38Hypoalphalipoproteinemia (HP:0003233)2.84067903
39Increased variability in muscle fiber diameter (HP:0003557)2.83130957
40Difficulty climbing stairs (HP:0003551)2.80004231
41Neck muscle weakness (HP:0000467)2.75601561
42Fetal akinesia sequence (HP:0001989)2.75151251
43Abnormality of the calcaneus (HP:0008364)2.74208865
44Palpitations (HP:0001962)2.72289812
45Supraventricular tachycardia (HP:0004755)2.70907451
46Bundle branch block (HP:0011710)2.70455622
47Calcaneovalgus deformity (HP:0001848)2.67678585
48Syncope (HP:0001279)2.67326186
49Rimmed vacuoles (HP:0003805)2.66811868
50Supraventricular arrhythmia (HP:0005115)2.64443692
51Ketosis (HP:0001946)2.63696194
52Ventricular arrhythmia (HP:0004308)2.62357819
53Areflexia of lower limbs (HP:0002522)2.56627798
54Prolonged QT interval (HP:0001657)2.56563176
55Heart block (HP:0012722)2.52103282
56Frequent falls (HP:0002359)2.46598565
57Abnormal finger flexion creases (HP:0006143)2.46277425
58Hypoplastic ischia (HP:0003175)2.42891666
59Distal lower limb muscle weakness (HP:0009053)2.41587001
60Hyperkalemia (HP:0002153)2.40533572
61Hip contracture (HP:0003273)2.39458471
62Atrioventricular block (HP:0001678)2.37408814
63Deformed tarsal bones (HP:0008119)2.36603344
64Abnormal atrioventricular conduction (HP:0005150)2.35747462
65EMG: neuropathic changes (HP:0003445)2.35306190
66Abnormality of fatty-acid metabolism (HP:0004359)2.32468186
67Bulbar palsy (HP:0001283)2.30661663
68Malignant hyperthermia (HP:0002047)2.29299020
69Progressive muscle weakness (HP:0003323)2.28586978
70Hyperammonemia (HP:0001987)2.26687167
71Weak cry (HP:0001612)2.24054920
72Abnormality of the ischium (HP:0003174)2.23430265
73Hyperinsulinemic hypoglycemia (HP:0000825)2.21193303
74Slender build (HP:0001533)2.19684297
75Generalized muscle weakness (HP:0003324)2.16272339
76Hyperglycinuria (HP:0003108)2.15561251
77Hyperglycemia (HP:0003074)2.14664139
78Hypolipoproteinemia (HP:0010981)2.14012613
79Abnormality of the neuromuscular junction (HP:0003398)2.12547696
80Popliteal pterygium (HP:0009756)2.12299566
81Mildly elevated creatine phosphokinase (HP:0008180)2.11972070
82Dicarboxylic aciduria (HP:0003215)2.09719166
83Abnormality of dicarboxylic acid metabolism (HP:0010995)2.09719166
84Metatarsus adductus (HP:0001840)2.08204600
85Muscular dystrophy (HP:0003560)2.06078283
86Cholelithiasis (HP:0001081)2.03943949
87Spinal rigidity (HP:0003306)2.02816504
88Long clavicles (HP:0000890)2.00049525
89Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.99040965
90Facial diplegia (HP:0001349)1.94245350
91Abnormality of glycine metabolism (HP:0010895)1.93006319
92Abnormality of serine family amino acid metabolism (HP:0010894)1.93006319
93Deep venous thrombosis (HP:0002625)1.92209135
94Gowers sign (HP:0003391)1.91257982
95Xanthomatosis (HP:0000991)1.90553620
96Ulnar deviation of finger (HP:0009465)1.89021982
97Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.88942385
98Scapular winging (HP:0003691)1.88824374
99Abnormal gallbladder morphology (HP:0012437)1.88352243
100Left ventricular hypertrophy (HP:0001712)1.87905482
101Abnormality of the shoulder girdle musculature (HP:0001435)1.87875219
102Insulin-resistant diabetes mellitus (HP:0000831)1.84995194
103Limb-girdle muscle atrophy (HP:0003797)1.83495038
104Intrahepatic cholestasis (HP:0001406)1.82647795
105Cerebral edema (HP:0002181)1.82433256
106Ventricular fibrillation (HP:0001663)1.82271068
107Distal lower limb amyotrophy (HP:0008944)1.80873871
108Abnormality of the foot musculature (HP:0001436)1.80607117
109Proximal amyotrophy (HP:0007126)1.80497918
110Abnormal EKG (HP:0003115)1.80307520
111Waddling gait (HP:0002515)1.78998263
112Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.78758622
113Metabolic acidosis (HP:0001942)1.78587087
114Toxemia of pregnancy (HP:0100603)1.77241493
115Abnormality of the hip-girdle musculature (HP:0001445)1.76749274
116Abnormality of the musculature of the pelvis (HP:0001469)1.76749274
117Increased purine levels (HP:0004368)1.75671832
118Hyperuricemia (HP:0002149)1.75671832
119Shoulder girdle muscle weakness (HP:0003547)1.75266838
120Fatigable weakness (HP:0003473)1.74825241
121Limited hip movement (HP:0008800)1.74078623
122Respiratory insufficiency due to muscle weakness (HP:0002747)1.71881340
123Pelvic girdle muscle weakness (HP:0003749)1.68893052
124Limb-girdle muscle weakness (HP:0003325)1.67456532
125Foot dorsiflexor weakness (HP:0009027)1.61721190
126Ragged-red muscle fibers (HP:0003200)1.60263675
127Lower limb amyotrophy (HP:0007210)1.59572891
128Ulnar deviation of the hand or of fingers of the hand (HP:0001193)1.59112097
129Paralysis (HP:0003470)1.58891445
130Exercise intolerance (HP:0003546)1.57865391
131Breech presentation (HP:0001623)1.52847193
132Amniotic constriction ring (HP:0009775)1.50104342
133Abnormality of placental membranes (HP:0011409)1.50104342
134Type 2 muscle fiber atrophy (HP:0003554)1.42555365
135Nonprogressive disorder (HP:0003680)1.32114082
136Increased serum pyruvate (HP:0003542)1.31470750
137Oligomenorrhea (HP:0000876)1.28254078

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OBSCN6.44220040
2TTN5.34821716
3PHKG14.91233822
4PHKG24.91233822
5BCKDK2.65648217
6TRIB32.49814784
7PINK12.49404118
8PDK32.41882991
9PDK42.41882991
10PKN22.35758944
11PIK3CG2.31377097
12INSRR2.18489107
13DMPK2.15741337
14PIK3CA2.07394763
15NEK11.97319732
16LMTK21.96452023
17MAP3K71.78939526
18MAP2K31.70928899
19MUSK1.68572834
20SIK11.65015877
21NME11.64282973
22PDK21.49904515
23STK241.48008431
24MAPK121.41308695
25MAP2K41.38232419
26ZAK1.37986524
27NEK91.35507737
28PRKAA21.33272841
29EEF2K1.29785882
30PBK1.26953505
31MYLK1.24089473
32PRKAA11.12789182
33TIE11.10819206
34LATS10.96501656
35GRK70.92176469
36CCNB10.83117838
37CAMK1G0.81615536
38STK38L0.79743388
39CAMK1D0.79615193
40TRPM70.78340430
41EPHB10.76837994
42FLT30.74071162
43CAMK2D0.72849675
44PRKD10.72762804
45ERBB40.69759476
46ROCK10.67443640
47IRAK30.67248969
48PKN10.66233253
49TNIK0.65148563
50PAK30.64805175
51STK380.63190029
52MAP2K60.62910676
53CDC42BPA0.61604974
54CAMK2G0.60970496
55SGK30.60808773
56RIPK10.60635485
57MOS0.60000104
58PTK60.59850881
59FGFR40.59160761
60MAPK110.57373756
61MAP3K30.56219403
62WNK10.56215337
63LIMK10.55949091
64MARK10.54734077
65ILK0.52993565
66MAP3K50.52742632
67KSR20.50307137
68MAP2K10.50072622
69SGK20.49149397
70RPS6KB20.48497641
71PDGFRA0.48419694
72SCYL20.47661139
73EPHA30.46278568
74MAP3K100.46180773
75STK390.46158189
76RPS6KB10.45963318
77PRKACB0.45919057
78MAPKAPK30.45781614
79TGFBR20.45503495
80CAMK40.45242858
81EIF2AK30.44845226
82AKT20.43335704
83MAPK70.42564789
84PRKACG0.41913714
85PDPK10.41549102
86ACVR1B0.40583045
87NLK0.40162520
88MAP3K130.39764372
89SGK10.39540307
90LATS20.39256887
91DYRK1B0.39138322
92JAK10.38581850
93ICK0.38408036
94PRKACA0.37863127
95CAMK2A0.35594573
96OXSR10.35536310
97TAOK20.35053104
98WNK40.34801727
99FGFR30.33187780
100PRKG10.32971633
101MAP3K40.32084728
102PDK10.30567251
103MAPK100.30413404
104RET0.30253350
105RPS6KA30.29372848
106CAMK2B0.28699508
107PNCK0.27623259
108MTOR0.26595688
109PRKCE0.26569033
110TRIM280.26532562
111CAMK10.25554204
112KSR10.24569048
113PAK60.24319434
114JAK20.23773421
115RAF10.23704173
116PLK40.22098352
117IRAK10.21362395
118IRAK20.21153297
119MST40.20418259
120PRKCH0.20288827
121ERN10.20007691
122MAP3K90.19949919
123STK40.19846066
124FER0.18883199
125SGK4940.18589109
126SGK2230.18589109
127BMPR1B0.18149708
128EIF2AK20.16003779
129STK30.15955456
130FGFR10.15466593
131MAP3K10.15164270
132ERBB30.15149556
133MAPK40.14552847
134PTK2B0.13074969
135MAP3K60.12518004
136RPS6KA10.11822519
137TTK0.09763239
138PRKDC0.09281223
139MAPK130.07996905
140AKT30.06542486
141GSK3B0.05866459
142TSSK60.05431131
143BRAF0.05125354

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.86848302
22-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.35055296
3Propanoate metabolism_Homo sapiens_hsa006403.29456004
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.27289017
5Fatty acid degradation_Homo sapiens_hsa000713.22131524
6Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.86535927
7Fatty acid metabolism_Homo sapiens_hsa012122.60139798
8Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.50607144
9Cardiac muscle contraction_Homo sapiens_hsa042602.37530642
10Dilated cardiomyopathy_Homo sapiens_hsa054142.32138011
11Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.20057884
12Carbon metabolism_Homo sapiens_hsa012002.11832234
13Arginine biosynthesis_Homo sapiens_hsa002202.11473223
14Nitrogen metabolism_Homo sapiens_hsa009102.11021231
15Primary bile acid biosynthesis_Homo sapiens_hsa001202.04406356
16Butanoate metabolism_Homo sapiens_hsa006502.01319889
17Tryptophan metabolism_Homo sapiens_hsa003801.92737558
18Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.91223054
19* Starch and sucrose metabolism_Homo sapiens_hsa005001.82324559
20Pyruvate metabolism_Homo sapiens_hsa006201.81543168
21PPAR signaling pathway_Homo sapiens_hsa033201.81137222
22Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.64203874
23beta-Alanine metabolism_Homo sapiens_hsa004101.53835389
24Peroxisome_Homo sapiens_hsa041461.45919480
25Fatty acid elongation_Homo sapiens_hsa000621.39238664
26Fatty acid biosynthesis_Homo sapiens_hsa000611.37596837
27Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.35429405
28Insulin resistance_Homo sapiens_hsa049311.35426047
29Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.34612353
30Glucagon signaling pathway_Homo sapiens_hsa049221.33123512
31Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.29917909
32Biosynthesis of amino acids_Homo sapiens_hsa012301.28695490
33Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.27976442
34Complement and coagulation cascades_Homo sapiens_hsa046101.24053551
35Adipocytokine signaling pathway_Homo sapiens_hsa049201.16874886
36Parkinsons disease_Homo sapiens_hsa050121.15074015
37Arginine and proline metabolism_Homo sapiens_hsa003301.11773629
38Insulin signaling pathway_Homo sapiens_hsa049101.11770575
39Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.11765573
40Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.11317259
41Lysine degradation_Homo sapiens_hsa003101.08258007
42Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.08105100
43Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.06807922
44Oxidative phosphorylation_Homo sapiens_hsa001901.05173465
45Phenylalanine metabolism_Homo sapiens_hsa003601.04621623
46Pentose and glucuronate interconversions_Homo sapiens_hsa000401.03763761
47Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.99277827
48Bile secretion_Homo sapiens_hsa049760.97853073
49Alzheimers disease_Homo sapiens_hsa050100.94999595
50AMPK signaling pathway_Homo sapiens_hsa041520.90049016
51Galactose metabolism_Homo sapiens_hsa000520.88756717
52ABC transporters_Homo sapiens_hsa020100.88143419
53Tyrosine metabolism_Homo sapiens_hsa003500.86130081
54Circadian rhythm_Homo sapiens_hsa047100.85685691
55Caffeine metabolism_Homo sapiens_hsa002320.82614140
56Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.81001849
57Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.80024563
58Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.79278631
59Sulfur metabolism_Homo sapiens_hsa009200.71666939
60Fructose and mannose metabolism_Homo sapiens_hsa000510.69254347
61Staphylococcus aureus infection_Homo sapiens_hsa051500.66286129
62Viral myocarditis_Homo sapiens_hsa054160.65475006
63Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.65365033
64Calcium signaling pathway_Homo sapiens_hsa040200.64658205
65Long-term potentiation_Homo sapiens_hsa047200.64581932
66Chemical carcinogenesis_Homo sapiens_hsa052040.61573848
67Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.61337000
68cGMP-PKG signaling pathway_Homo sapiens_hsa040220.60112006
69Oxytocin signaling pathway_Homo sapiens_hsa049210.58949339
70Adherens junction_Homo sapiens_hsa045200.57396493
71Histidine metabolism_Homo sapiens_hsa003400.56995178
72Fat digestion and absorption_Homo sapiens_hsa049750.56760283
73Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.56545904
74Retinol metabolism_Homo sapiens_hsa008300.54819902
75Type II diabetes mellitus_Homo sapiens_hsa049300.54422800
76Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.52043522
77Steroid hormone biosynthesis_Homo sapiens_hsa001400.51678728
78Thyroid hormone signaling pathway_Homo sapiens_hsa049190.51410356
79Cysteine and methionine metabolism_Homo sapiens_hsa002700.46855112
80Huntingtons disease_Homo sapiens_hsa050160.46221150
81Glycerolipid metabolism_Homo sapiens_hsa005610.45843134
82GnRH signaling pathway_Homo sapiens_hsa049120.44675518
83Longevity regulating pathway - mammal_Homo sapiens_hsa042110.44628268
84Oocyte meiosis_Homo sapiens_hsa041140.41646860
85Thyroid cancer_Homo sapiens_hsa052160.40482675
86Central carbon metabolism in cancer_Homo sapiens_hsa052300.40295950
87Selenocompound metabolism_Homo sapiens_hsa004500.39829207
88Focal adhesion_Homo sapiens_hsa045100.38419943
89Pentose phosphate pathway_Homo sapiens_hsa000300.38345078
90Insulin secretion_Homo sapiens_hsa049110.36147458
91Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.35407137
92Vascular smooth muscle contraction_Homo sapiens_hsa042700.34623826
93* Metabolic pathways_Homo sapiens_hsa011000.32198874
94Maturity onset diabetes of the young_Homo sapiens_hsa049500.29782736
95Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.26365074
96Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.25657715
97Tight junction_Homo sapiens_hsa045300.24607942
98HIF-1 signaling pathway_Homo sapiens_hsa040660.23915348
99Renin secretion_Homo sapiens_hsa049240.22253352
100Glioma_Homo sapiens_hsa052140.22208203
101Gastric acid secretion_Homo sapiens_hsa049710.20122182
102Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.19967005
103Drug metabolism - other enzymes_Homo sapiens_hsa009830.18901857
104Regulation of actin cytoskeleton_Homo sapiens_hsa048100.18171294
105ECM-receptor interaction_Homo sapiens_hsa045120.17961980
106FoxO signaling pathway_Homo sapiens_hsa040680.17775342
107Melanogenesis_Homo sapiens_hsa049160.17547347
108Ovarian steroidogenesis_Homo sapiens_hsa049130.16858509
109Wnt signaling pathway_Homo sapiens_hsa043100.16346523
110Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.16250812
111Sulfur relay system_Homo sapiens_hsa041220.15495816
112Amoebiasis_Homo sapiens_hsa051460.15492458
113Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.15061754
114Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.14867950
115Proteoglycans in cancer_Homo sapiens_hsa052050.13466105
116cAMP signaling pathway_Homo sapiens_hsa040240.12530496
117TGF-beta signaling pathway_Homo sapiens_hsa043500.12225790
118Glycerophospholipid metabolism_Homo sapiens_hsa005640.11612663
119Purine metabolism_Homo sapiens_hsa002300.10718888
120mTOR signaling pathway_Homo sapiens_hsa041500.09709824
121Aldosterone synthesis and secretion_Homo sapiens_hsa049250.09479711
122Pancreatic secretion_Homo sapiens_hsa049720.09197800
123RNA degradation_Homo sapiens_hsa030180.09076978

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