AGK

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a mitochondrial membrane protein involved in lipid and glycerolipid metabolism. The encoded protein is a lipid kinase that catalyzes the formation of phosphatidic and lysophosphatidic acids. Defects in this gene have been associated with mitochondrial DNA depletion syndrome 10. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proteasome assembly (GO:0043248)4.36018054
2DNA replication checkpoint (GO:0000076)3.79824500
3neuron cell-cell adhesion (GO:0007158)3.70330049
4cullin deneddylation (GO:0010388)3.58469131
5tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.55021881
6RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.55021881
7protein complex biogenesis (GO:0070271)3.50007155
8mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.48098777
9mitochondrial respiratory chain complex I assembly (GO:0032981)3.48098777
10NADH dehydrogenase complex assembly (GO:0010257)3.48098777
11peptidyl-histidine modification (GO:0018202)3.47602847
12protein deneddylation (GO:0000338)3.44192175
13postreplication repair (GO:0006301)3.40516288
14presynaptic membrane assembly (GO:0097105)3.31075730
15positive regulation of histone H3-K4 methylation (GO:0051571)3.26254409
16mitochondrial respiratory chain complex assembly (GO:0033108)3.24406068
17RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.23325687
18histone H2A acetylation (GO:0043968)3.23189010
19nuclear pore complex assembly (GO:0051292)3.18501173
20postsynaptic membrane organization (GO:0001941)3.18083668
21rRNA catabolic process (GO:0016075)3.17638014
22mitotic nuclear envelope disassembly (GO:0007077)3.13245961
23nucleotide-excision repair, DNA gap filling (GO:0006297)3.13089177
24histone mRNA metabolic process (GO:0008334)3.12185458
25dopamine transport (GO:0015872)3.11663146
267-methylguanosine RNA capping (GO:0009452)3.10074687
27RNA capping (GO:0036260)3.10074687
28double-strand break repair via nonhomologous end joining (GO:0006303)3.09434094
29non-recombinational repair (GO:0000726)3.09434094
30transcription elongation from RNA polymerase III promoter (GO:0006385)3.08459932
31termination of RNA polymerase III transcription (GO:0006386)3.08459932
327-methylguanosine mRNA capping (GO:0006370)3.07534002
33somatic diversification of immune receptors via somatic mutation (GO:0002566)3.06594481
34somatic hypermutation of immunoglobulin genes (GO:0016446)3.06594481
35negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.04633157
36L-methionine salvage (GO:0071267)3.03214090
37L-methionine biosynthetic process (GO:0071265)3.03214090
38amino acid salvage (GO:0043102)3.03214090
39maturation of 5.8S rRNA (GO:0000460)3.02659942
40positive regulation of protein homodimerization activity (GO:0090073)3.01352477
41negative regulation of DNA recombination (GO:0045910)3.01194681
42mitotic recombination (GO:0006312)3.00284501
43positive regulation of immune response to tumor cell (GO:0002839)2.99771110
44regulation of immune response to tumor cell (GO:0002837)2.99771110
45regulation of response to tumor cell (GO:0002834)2.99771110
46positive regulation of response to tumor cell (GO:0002836)2.99771110
47presynaptic membrane organization (GO:0097090)2.99678152
48regulation of mitotic spindle checkpoint (GO:1903504)2.97622606
49regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.97622606
50ribosome assembly (GO:0042255)2.97381561
51somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.96145764
52isotype switching (GO:0045190)2.96145764
53somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.96145764
54deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.95444147
55DNA double-strand break processing (GO:0000729)2.95050525
56protein K6-linked ubiquitination (GO:0085020)2.94628127
57respiratory chain complex IV assembly (GO:0008535)2.93487774
58nuclear pore organization (GO:0006999)2.93207382
59rRNA modification (GO:0000154)2.92429170
60regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.89882901
61IMP biosynthetic process (GO:0006188)2.89650332
62chaperone-mediated protein transport (GO:0072321)2.87975031
63positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.86287735
64establishment of integrated proviral latency (GO:0075713)2.85635266
65regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.85484276
66rRNA methylation (GO:0031167)2.85393018
67cytochrome complex assembly (GO:0017004)2.84587798
68telomere maintenance via telomerase (GO:0007004)2.83713491
69branched-chain amino acid catabolic process (GO:0009083)2.82810740
70hyperosmotic salinity response (GO:0042538)2.82499252
71regulation of mitochondrial translation (GO:0070129)2.81893374
72somatic cell DNA recombination (GO:0016444)2.80720935
73somatic diversification of immune receptors via germline recombination within a single locus (GO:0002.80720935
74pseudouridine synthesis (GO:0001522)2.80657173
75telomere maintenance via semi-conservative replication (GO:0032201)2.80469273
76tRNA aminoacylation (GO:0043039)2.80401332
77amino acid activation (GO:0043038)2.80401332
78nucleobase biosynthetic process (GO:0046112)2.80244509
79DNA catabolic process, exonucleolytic (GO:0000738)2.79632936
80purine nucleobase biosynthetic process (GO:0009113)2.79244553
81membrane disassembly (GO:0030397)2.78423539
82nuclear envelope disassembly (GO:0051081)2.78423539
83somatic diversification of immune receptors (GO:0002200)2.78344381
84anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.77998210
85microtubule depolymerization (GO:0007019)2.76440253
86nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.76209121
87DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.75374956
88polyketide metabolic process (GO:0030638)2.75209028
89doxorubicin metabolic process (GO:0044598)2.75209028
90daunorubicin metabolic process (GO:0044597)2.75209028
91DNA deamination (GO:0045006)2.75075343
92DNA ligation (GO:0006266)2.74945832
93exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.74556830
94CENP-A containing nucleosome assembly (GO:0034080)2.73510216
95somatic recombination of immunoglobulin gene segments (GO:0016447)2.73474962
96positive regulation of ligase activity (GO:0051351)2.73363053
97intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.73342510
98signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.73342510
99signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.73179833
100signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.73179833
101signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.73179833
102ubiquinone biosynthetic process (GO:0006744)2.73122762
103negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.73091622
104negative regulation of ligase activity (GO:0051352)2.73091622
105mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.72755826
106lactate metabolic process (GO:0006089)2.72479076
107regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.71798336
108somatic diversification of immunoglobulins (GO:0016445)2.71020422
109DNA strand elongation (GO:0022616)2.70565543
110vocalization behavior (GO:0071625)2.70101472
111DNA replication initiation (GO:0006270)2.68977087
112protein localization to synapse (GO:0035418)2.67401696
113protein neddylation (GO:0045116)2.65036655
114telomere maintenance via recombination (GO:0000722)2.63889815
115single strand break repair (GO:0000012)2.63149159
116kinetochore assembly (GO:0051382)2.63073025
117opioid receptor signaling pathway (GO:0038003)2.62091911
118ribosomal small subunit assembly (GO:0000028)2.61885912
119regulation of cellular amino acid metabolic process (GO:0006521)2.59785521
120DNA strand elongation involved in DNA replication (GO:0006271)2.59548280
121positive regulation of mitochondrial fission (GO:0090141)2.59535393
122tRNA processing (GO:0008033)2.59147388
123signal transduction involved in DNA integrity checkpoint (GO:0072401)2.58904227
124signal transduction involved in DNA damage checkpoint (GO:0072422)2.58904227
125transcription-coupled nucleotide-excision repair (GO:0006283)2.58295028
126signal transduction involved in cell cycle checkpoint (GO:0072395)2.58223623
127deoxyribose phosphate biosynthetic process (GO:0046385)2.57634390
1282-deoxyribonucleotide biosynthetic process (GO:0009265)2.57634390
129chromatin remodeling at centromere (GO:0031055)2.56193488
130ribosome biogenesis (GO:0042254)2.55171339
131regulation of synapse maturation (GO:0090128)2.53557194
132replication fork processing (GO:0031297)2.53520848
133regulation of helicase activity (GO:0051095)2.53056724
134maturation of SSU-rRNA (GO:0030490)2.52564263
135viral mRNA export from host cell nucleus (GO:0046784)2.51534472
136maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.49142951
137lymphoid progenitor cell differentiation (GO:0002320)2.48415720
138transcription elongation from RNA polymerase I promoter (GO:0006362)2.46011442
139iron-sulfur cluster assembly (GO:0016226)2.45986518
140metallo-sulfur cluster assembly (GO:0031163)2.45986518
141pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.45693424
142synaptic vesicle exocytosis (GO:0016079)2.45176577
143telomere maintenance via telomere lengthening (GO:0010833)2.44692515
144L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.43988774
145kinetochore organization (GO:0051383)2.43416917
146neurotransmitter-gated ion channel clustering (GO:0072578)2.43348139
147positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.42825704
148regulation of nuclear cell cycle DNA replication (GO:0033262)2.42326381
149deoxyribonucleotide biosynthetic process (GO:0009263)2.41639248

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.09391090
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.59208436
3NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.56883104
4GBX2_23144817_ChIP-Seq_PC3_Human3.13682033
5SALL1_21062744_ChIP-ChIP_HESCs_Human3.05229404
6HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.04018162
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.00742642
8MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.89637717
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.89239216
10GABP_17652178_ChIP-ChIP_JURKAT_Human2.80893150
11HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.64619907
12TAF15_26573619_Chip-Seq_HEK293_Human2.49406042
13* MYC_18555785_ChIP-Seq_MESCs_Mouse2.42071244
14RBPJ_22232070_ChIP-Seq_NCS_Mouse2.27118988
15EZH2_22144423_ChIP-Seq_EOC_Human2.24122571
16E2F4_17652178_ChIP-ChIP_JURKAT_Human2.22197182
17THAP11_20581084_ChIP-Seq_MESCs_Mouse2.21542203
18CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.15962252
19ETS1_20019798_ChIP-Seq_JURKAT_Human2.13087794
20ELF1_17652178_ChIP-ChIP_JURKAT_Human2.12473286
21SRF_21415370_ChIP-Seq_HL-1_Mouse2.11069392
22CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.10221125
23FUS_26573619_Chip-Seq_HEK293_Human2.09440360
24VDR_23849224_ChIP-Seq_CD4+_Human2.00130417
25ZFP57_27257070_Chip-Seq_ESCs_Mouse1.99209070
26YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.93499223
27MYC_18358816_ChIP-ChIP_MESCs_Mouse1.83878147
28POU3F2_20337985_ChIP-ChIP_501MEL_Human1.83056403
29* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.77785893
30ZNF274_21170338_ChIP-Seq_K562_Hela1.77521594
31ELK1_19687146_ChIP-ChIP_HELA_Human1.75525900
32FOXP3_21729870_ChIP-Seq_TREG_Human1.75184698
33HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.75067876
34CREB1_15753290_ChIP-ChIP_HEK293T_Human1.74283629
35PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.72697260
36FOXM1_23109430_ChIP-Seq_U2OS_Human1.71885969
37EWS_26573619_Chip-Seq_HEK293_Human1.70213507
38YY1_21170310_ChIP-Seq_MESCs_Mouse1.68367286
39HOXB4_20404135_ChIP-ChIP_EML_Mouse1.67647992
40FLI1_27457419_Chip-Seq_LIVER_Mouse1.65769622
41NOTCH1_21737748_ChIP-Seq_TLL_Human1.65126724
42IGF1R_20145208_ChIP-Seq_DFB_Human1.64893476
43* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.63657283
44TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.60754960
45SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.57206329
46IRF1_19129219_ChIP-ChIP_H3396_Human1.55294087
47PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.52891307
48PCGF2_27294783_Chip-Seq_ESCs_Mouse1.49470297
49E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.48677140
50ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.46964730
51CTBP2_25329375_ChIP-Seq_LNCAP_Human1.43555367
52DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.42758128
53* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.41284404
54EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.39882820
55MYC_19079543_ChIP-ChIP_MESCs_Mouse1.38855289
56DCP1A_22483619_ChIP-Seq_HELA_Human1.37391720
57P300_19829295_ChIP-Seq_ESCs_Human1.36075245
58BMI1_23680149_ChIP-Seq_NPCS_Mouse1.32886446
59E2F1_21310950_ChIP-Seq_MCF-7_Human1.31147801
60MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.29220108
61* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.27717391
62NELFA_20434984_ChIP-Seq_ESCs_Mouse1.27535554
63SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.26913912
64FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.25301067
65MYC_18940864_ChIP-ChIP_HL60_Human1.25012408
66KDM5A_27292631_Chip-Seq_BREAST_Human1.23173335
67* GABP_19822575_ChIP-Seq_HepG2_Human1.22570453
68MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.21777124
69TTF2_22483619_ChIP-Seq_HELA_Human1.21486210
70GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21128390
71RNF2_27304074_Chip-Seq_NSC_Mouse1.19594915
72POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.17377722
73* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.17340307
74IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.14634805
75CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.11763003
76FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.11729637
77NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.11227937
78PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.10376405
79CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.09270903
80GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.09098417
81POU5F1_16153702_ChIP-ChIP_HESCs_Human1.08482274
82SMAD_19615063_ChIP-ChIP_OVARY_Human1.08351949
83FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.08135430
84SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.06028867
85CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.05540033
86* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.03921078
87E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.02929560
88POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.02178163
89JUN_21703547_ChIP-Seq_K562_Human1.00376651
90TP53_22573176_ChIP-Seq_HFKS_Human1.00362868
91CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00356711
92PADI4_21655091_ChIP-ChIP_MCF-7_Human1.00115690
93STAT3_18555785_Chip-Seq_ESCs_Mouse0.99974715
94* SMAD4_21799915_ChIP-Seq_A2780_Human0.99676945
95MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.98427214
96ER_23166858_ChIP-Seq_MCF-7_Human0.98039804
97BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.95611238
98E2F1_18555785_Chip-Seq_ESCs_Mouse0.95417096
99NANOG_18555785_Chip-Seq_ESCs_Mouse0.94755649
100EZH2_27294783_Chip-Seq_NPCs_Mouse0.94703035
101REST_21632747_ChIP-Seq_MESCs_Mouse0.94098936
102NFE2_27457419_Chip-Seq_LIVER_Mouse0.94051695
103MYCN_18555785_ChIP-Seq_MESCs_Mouse0.93661725
104ERG_20887958_ChIP-Seq_HPC-7_Mouse0.93408737
105* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.93167685
106SALL4_22934838_ChIP-ChIP_CD34+_Human0.91798953
107* XRN2_22483619_ChIP-Seq_HELA_Human0.91539177
108SUZ12_27294783_Chip-Seq_NPCs_Mouse0.90719449
109SOX9_26525672_Chip-Seq_HEART_Mouse0.89815376
110P53_22387025_ChIP-Seq_ESCs_Mouse0.89577347
111SUZ12_18555785_Chip-Seq_ESCs_Mouse0.89533863
112TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.89050390
113EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.88103115
114CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.88070761
115CIITA_25753668_ChIP-Seq_RAJI_Human0.87501511
116VDR_22108803_ChIP-Seq_LS180_Human0.87430711
117AR_21909140_ChIP-Seq_LNCAP_Human0.83215505
118TFEB_21752829_ChIP-Seq_HELA_Human0.83053318
119EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.80674278
120ELK1_22589737_ChIP-Seq_MCF10A_Human0.80011896
121RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.79926476
122* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.79664789
123CBP_20019798_ChIP-Seq_JUKART_Human0.78331577
124IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.78331577
125ZFX_18555785_ChIP-Seq_MESCs_Mouse0.78290992
126CRX_20693478_ChIP-Seq_RETINA_Mouse0.78285039

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern3.65527563
2MP0001188_hyperpigmentation3.25739814
3MP0006292_abnormal_olfactory_placode2.74054058
4MP0008058_abnormal_DNA_repair2.59452944
5MP0008877_abnormal_DNA_methylation2.53681017
6MP0010094_abnormal_chromosome_stability2.46518202
7MP0003787_abnormal_imprinting2.41801567
8MP0001968_abnormal_touch/_nociception2.37326802
9MP0001529_abnormal_vocalization2.34255930
10MP0009745_abnormal_behavioral_response2.25493103
11MP0008057_abnormal_DNA_replication2.21187888
12MP0005075_abnormal_melanosome_morpholog2.19744760
13MP0004859_abnormal_synaptic_plasticity2.17824371
14MP0002736_abnormal_nociception_after2.17652232
15MP0009046_muscle_twitch2.16573352
16MP0003635_abnormal_synaptic_transmissio2.11484253
17MP0006072_abnormal_retinal_apoptosis2.09500403
18MP0001905_abnormal_dopamine_level2.04859868
19MP0005171_absent_coat_pigmentation2.04856077
20MP0003950_abnormal_plasma_membrane2.02649311
21MP0000015_abnormal_ear_pigmentation2.02505233
22MP0002822_catalepsy1.98614046
23MP0002735_abnormal_chemical_nociception1.94294401
24MP0002234_abnormal_pharynx_morphology1.90054767
25MP0002572_abnormal_emotion/affect_behav1.88378356
26MP0005646_abnormal_pituitary_gland1.88163384
27MP0009697_abnormal_copulation1.83618364
28MP0002064_seizures1.83089491
29MP0002396_abnormal_hematopoietic_system1.82021470
30MP0004147_increased_porphyrin_level1.79318181
31MP0005410_abnormal_fertilization1.79079153
32MP0002063_abnormal_learning/memory/cond1.76901847
33MP0002272_abnormal_nervous_system1.76602738
34MP0008995_early_reproductive_senescence1.73656668
35MP0008789_abnormal_olfactory_epithelium1.69385810
36MP0000372_irregular_coat_pigmentation1.63520095
37MP0001346_abnormal_lacrimal_gland1.61303078
38MP0001986_abnormal_taste_sensitivity1.60383839
39MP0002734_abnormal_mechanical_nocicepti1.58638606
40MP0003121_genomic_imprinting1.57823072
41MP0002067_abnormal_sensory_capabilities1.54324454
42MP0003123_paternal_imprinting1.53603285
43MP0005174_abnormal_tail_pigmentation1.53273374
44MP0003693_abnormal_embryo_hatching1.50414428
45MP0005253_abnormal_eye_physiology1.49037886
46MP0001486_abnormal_startle_reflex1.45734001
47MP0004270_analgesia1.44617076
48MP0001501_abnormal_sleep_pattern1.44455604
49MP0003111_abnormal_nucleus_morphology1.43107491
50MP0008007_abnormal_cellular_replicative1.42550045
51MP0003077_abnormal_cell_cycle1.42163782
52MP0006276_abnormal_autonomic_nervous1.40488741
53MP0005551_abnormal_eye_electrophysiolog1.36098594
54MP0002095_abnormal_skin_pigmentation1.33048444
55MP0003122_maternal_imprinting1.30414495
56MP0004957_abnormal_blastocyst_morpholog1.28270655
57MP0004142_abnormal_muscle_tone1.27762427
58MP0005395_other_phenotype1.27548421
59MP0005386_behavior/neurological_phenoty1.27264758
60MP0004924_abnormal_behavior1.27264758
61MP0005409_darkened_coat_color1.25532204
62MP0002876_abnormal_thyroid_physiology1.23320148
63MP0005367_renal/urinary_system_phenotyp1.22106126
64MP0000516_abnormal_urinary_system1.22106126
65MP0000653_abnormal_sex_gland1.15418735
66MP0001145_abnormal_male_reproductive1.14640479
67MP0003698_abnormal_male_reproductive1.14340621
68MP0002160_abnormal_reproductive_system1.14246881
69MP0000358_abnormal_cell_content/1.14075934
70MP0002184_abnormal_innervation1.13818410
71MP0001661_extended_life_span1.13607639
72MP0008260_abnormal_autophagy1.12147798
73MP0001984_abnormal_olfaction1.10886267
74MP0002557_abnormal_social/conspecific_i1.10377827
75MP0001970_abnormal_pain_threshold1.07781083
76MP0002638_abnormal_pupillary_reflex1.06581641
77MP0002102_abnormal_ear_morphology1.05144475
78MP0003718_maternal_effect1.04379426
79MP0008932_abnormal_embryonic_tissue1.04103451
80MP0003879_abnormal_hair_cell1.01215718
81MP0004043_abnormal_pH_regulation1.01076937
82MP0003567_abnormal_fetal_cardiomyocyte0.99580115
83MP0002733_abnormal_thermal_nociception0.99366194
84MP0003786_premature_aging0.98772263
85MP0001730_embryonic_growth_arrest0.98068618
86MP0000569_abnormal_digit_pigmentation0.97231941
87MP0000631_abnormal_neuroendocrine_gland0.94745134
88MP0002163_abnormal_gland_morphology0.94161559
89MP0002751_abnormal_autonomic_nervous0.93369567
90MP0005671_abnormal_response_to0.93066800
91MP0002938_white_spotting0.92807444
92MP0005423_abnormal_somatic_nervous0.90224153
93MP0005084_abnormal_gallbladder_morpholo0.89472622
94MP0002210_abnormal_sex_determination0.89186417
95MP0002019_abnormal_tumor_incidence0.87385690
96MP0003656_abnormal_erythrocyte_physiolo0.87160160
97MP0001697_abnormal_embryo_size0.85596130
98MP0006036_abnormal_mitochondrial_physio0.85007527
99MP0003890_abnormal_embryonic-extraembry0.84730421
100MP0005389_reproductive_system_phenotype0.84394947
101MP0002138_abnormal_hepatobiliary_system0.83722268
102MP0010307_abnormal_tumor_latency0.83569094
103MP0004215_abnormal_myocardial_fiber0.83075578
104MP0003763_abnormal_thymus_physiology0.81281896
105MP0000427_abnormal_hair_cycle0.81278397
106MP0001440_abnormal_grooming_behavior0.81215408
107MP0004811_abnormal_neuron_physiology0.81053157
108MP0001764_abnormal_homeostasis0.80262861
109MP0000313_abnormal_cell_death0.79722522
110MP0001963_abnormal_hearing_physiology0.79349076
111MP0004145_abnormal_muscle_electrophysio0.76353820
112MP0001672_abnormal_embryogenesis/_devel0.76334290
113MP0005380_embryogenesis_phenotype0.76334290
114MP0005645_abnormal_hypothalamus_physiol0.75700871
115MP0001919_abnormal_reproductive_system0.75634786
116MP0002161_abnormal_fertility/fecundity0.75607589
117MP0008569_lethality_at_weaning0.75332337
118MP0000350_abnormal_cell_proliferation0.74608218
119MP0002233_abnormal_nose_morphology0.74574852
120MP0000681_abnormal_thyroid_gland0.74554636
121MP0000778_abnormal_nervous_system0.73997526
122MP0004808_abnormal_hematopoietic_stem0.72862711
123MP0003699_abnormal_female_reproductive0.72780180
124MP0008873_increased_physiological_sensi0.72765055
125MP0000490_abnormal_crypts_of0.72322663
126MP0005379_endocrine/exocrine_gland_phen0.71913761
127MP0003136_yellow_coat_color0.71362478
128MP0003137_abnormal_impulse_conducting0.71142288
129MP0006035_abnormal_mitochondrial_morpho0.70049081
130MP0002066_abnormal_motor_capabilities/c0.69406072
131MP0001502_abnormal_circadian_rhythm0.69207045
132MP0008872_abnormal_physiological_respon0.69095173
133MP0005220_abnormal_exocrine_pancreas0.69046860
134MP0005394_taste/olfaction_phenotype0.68449600
135MP0005499_abnormal_olfactory_system0.68449600
136MP0005408_hypopigmentation0.68054267
137MP0001929_abnormal_gametogenesis0.67969104
138MP0001293_anophthalmia0.66808692
139MP0009379_abnormal_foot_pigmentation0.66065336
140MP0009333_abnormal_splenocyte_physiolog0.65763004
141MP0002398_abnormal_bone_marrow0.65214551
142MP0001119_abnormal_female_reproductive0.64874009
143MP0009703_decreased_birth_body0.64864819
144MP0002075_abnormal_coat/hair_pigmentati0.64585547
145MP0003119_abnormal_digestive_system0.64290572
146MP0005187_abnormal_penis_morphology0.64131859
147MP0003943_abnormal_hepatobiliary_system0.62967873

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)4.11001454
2Febrile seizures (HP:0002373)3.76512708
3Type 2 muscle fiber atrophy (HP:0003554)3.65189714
4Acute necrotizing encephalopathy (HP:0006965)3.61911401
5Atonic seizures (HP:0010819)3.54092016
6Degeneration of anterior horn cells (HP:0002398)3.45804270
7Abnormality of the anterior horn cell (HP:0006802)3.45804270
8Abnormal mitochondria in muscle tissue (HP:0008316)3.43819688
9Hyperventilation (HP:0002883)3.39548913
10Hypothermia (HP:0002045)3.22409124
11Mitochondrial inheritance (HP:0001427)3.20171937
12Abnormal hair whorl (HP:0010721)3.18851361
13Chromosomal breakage induced by crosslinking agents (HP:0003221)3.06281385
14Epileptic encephalopathy (HP:0200134)3.02708311
15Muscle fiber atrophy (HP:0100295)3.01248206
16Increased CSF lactate (HP:0002490)3.00024257
17Type I transferrin isoform profile (HP:0003642)2.99859797
18Chromsome breakage (HP:0040012)2.98233900
19Hepatocellular necrosis (HP:0001404)2.96928588
20Nephrogenic diabetes insipidus (HP:0009806)2.95204475
21Abnormality of the pons (HP:0007361)2.95065401
22Birth length less than 3rd percentile (HP:0003561)2.93754151
23Progressive macrocephaly (HP:0004481)2.92488978
24Medial flaring of the eyebrow (HP:0010747)2.88653504
25Gait imbalance (HP:0002141)2.82126895
26Congenital primary aphakia (HP:0007707)2.74889076
27Duplicated collecting system (HP:0000081)2.72136953
28Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.65587416
29Decreased activity of mitochondrial respiratory chain (HP:0008972)2.65587416
30Acute encephalopathy (HP:0006846)2.61790043
31Abnormality of alanine metabolism (HP:0010916)2.58188378
32Hyperalaninemia (HP:0003348)2.58188378
33Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.58188378
34Volvulus (HP:0002580)2.53528390
35Neoplasm of the adrenal gland (HP:0100631)2.52789007
36Progressive inability to walk (HP:0002505)2.50414774
37Pancreatic fibrosis (HP:0100732)2.49129949
38Protruding tongue (HP:0010808)2.46705559
39Postnatal microcephaly (HP:0005484)2.44072466
40Agnosia (HP:0010524)2.41781712
41Abnormality of glycolysis (HP:0004366)2.40519184
42Increased serum pyruvate (HP:0003542)2.40519184
43Abnormality of the preputium (HP:0100587)2.33241494
44Atrophy/Degeneration involving motor neurons (HP:0007373)2.33131335
45Inability to walk (HP:0002540)2.32572073
46Gaze-evoked nystagmus (HP:0000640)2.31722024
47Large for gestational age (HP:0001520)2.26857830
48Aplastic anemia (HP:0001915)2.25817514
49* Increased serum lactate (HP:0002151)2.25802312
50Poor coordination (HP:0002370)2.24815026
51Pancreatic islet-cell hyperplasia (HP:0004510)2.24581766
52True hermaphroditism (HP:0010459)2.22436884
53Increased hepatocellular lipid droplets (HP:0006565)2.20962289
54Progressive microcephaly (HP:0000253)2.19488092
55Spinal muscular atrophy (HP:0007269)2.19044361
56Hypoglycemic coma (HP:0001325)2.18982446
57Severe combined immunodeficiency (HP:0004430)2.18954396
58Abnormality of B cell number (HP:0010975)2.18133588
59Limb hypertonia (HP:0002509)2.18126431
60Abnormality of the labia minora (HP:0012880)2.18082526
61Broad-based gait (HP:0002136)2.16769426
62Carpal bone hypoplasia (HP:0001498)2.16701198
63Hepatic necrosis (HP:0002605)2.14975626
64Cerebral edema (HP:0002181)2.13808257
65Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.13771924
66Cerebral hypomyelination (HP:0006808)2.13277786
67Meckel diverticulum (HP:0002245)2.13213350
68Focal seizures (HP:0007359)2.12177220
69Aplasia/Hypoplasia of the tibia (HP:0005772)2.10870481
70Reduced antithrombin III activity (HP:0001976)2.10629594
71Abnormality of the ileum (HP:0001549)2.09622030
72Dialeptic seizures (HP:0011146)2.09481516
73Abnormal protein glycosylation (HP:0012346)2.08428403
74Abnormal glycosylation (HP:0012345)2.08428403
75Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.08428403
76Abnormal protein N-linked glycosylation (HP:0012347)2.08428403
77Panhypogammaglobulinemia (HP:0003139)2.07986761
78Renal cortical cysts (HP:0000803)2.07766432
79Neoplasm of the adrenal cortex (HP:0100641)2.07371678
80Molar tooth sign on MRI (HP:0002419)2.05891251
81Abnormality of midbrain morphology (HP:0002418)2.05891251
82Optic disc pallor (HP:0000543)2.04651771
83Short tibia (HP:0005736)2.04404980
84Poor suck (HP:0002033)2.04106298
85* Lactic acidosis (HP:0003128)2.03032065
86* Exercise intolerance (HP:0003546)2.02716998
87Premature graying of hair (HP:0002216)2.02176141
88Abnormality of T cell physiology (HP:0011840)2.00244015
89IgG deficiency (HP:0004315)2.00017662
90Fair hair (HP:0002286)1.99979028
91Myelodysplasia (HP:0002863)1.99800871
92Sloping forehead (HP:0000340)1.99411680
93B lymphocytopenia (HP:0010976)1.97536356
94Nonprogressive disorder (HP:0003680)1.97208710
95Absence seizures (HP:0002121)1.97016949
96* Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.96714718
97Microvesicular hepatic steatosis (HP:0001414)1.95421592
98Pendular nystagmus (HP:0012043)1.94906611
99Abnormality of the renal cortex (HP:0011035)1.94866951
100Abnormal delayed hypersensitivity skin test (HP:0002963)1.94765884
101Combined immunodeficiency (HP:0005387)1.93595752
102Eosinophilia (HP:0001880)1.92987537
103Abnormality of chromosome stability (HP:0003220)1.89902152
104Bone marrow hypocellularity (HP:0005528)1.89268730
105Nephronophthisis (HP:0000090)1.89132695
106Limb dystonia (HP:0002451)1.88839411
107Aplasia/Hypoplasia of the uvula (HP:0010293)1.87897835
108Abnormal biliary tract physiology (HP:0012439)1.86503327
109Bile duct proliferation (HP:0001408)1.86503327
110Thyroiditis (HP:0100646)1.85973662
111Genital tract atresia (HP:0001827)1.84264178
112Pancreatic cysts (HP:0001737)1.84227306
113Astrocytoma (HP:0009592)1.83495601
114Abnormality of the astrocytes (HP:0100707)1.83495601
115Squamous cell carcinoma (HP:0002860)1.81789548
116Ependymoma (HP:0002888)1.81693516
117Abnormality of DNA repair (HP:0003254)1.80755493
118Chronic hepatic failure (HP:0100626)1.79090223
119Neuroendocrine neoplasm (HP:0100634)1.78481835
120Renal Fanconi syndrome (HP:0001994)1.77837711
121Abnormality of endocrine pancreas physiology (HP:0012093)1.77019214
122Abnormality of the pancreatic islet cells (HP:0006476)1.77019214
123* 3-Methylglutaconic aciduria (HP:0003535)1.76069533
124Tongue fasciculations (HP:0001308)1.75984881
125Increased IgM level (HP:0003496)1.75592479
126Leukodystrophy (HP:0002415)1.75561689
127CNS demyelination (HP:0007305)1.74862793
128IgM deficiency (HP:0002850)1.74666393
129Abnormality of eosinophils (HP:0001879)1.73442405
130Vaginal atresia (HP:0000148)1.73287395
131Hypoproteinemia (HP:0003075)1.72369153
132Generalized myoclonic seizures (HP:0002123)1.72157102
133Respiratory failure (HP:0002878)1.72107889
134Premature ovarian failure (HP:0008209)1.71884333
135Lipid accumulation in hepatocytes (HP:0006561)1.70676552
136Autoimmune hemolytic anemia (HP:0001890)1.70087185
137Abnormal lung lobation (HP:0002101)1.69424682
138Hypoplasia of the capital femoral epiphysis (HP:0003090)1.69353710
139Generalized hypopigmentation of hair (HP:0011358)1.69338269
140Nephroblastoma (Wilms tumor) (HP:0002667)1.69288883
141Hypoglycemic seizures (HP:0002173)1.68194689
142Increased intramyocellular lipid droplets (HP:0012240)1.68176322
143Cutaneous melanoma (HP:0012056)1.67888756
144Abnormality of the renal collecting system (HP:0004742)1.66762003
145CNS hypomyelination (HP:0003429)1.65791980
146Poor eye contact (HP:0000817)1.65226904
147Abnormal respiratory epithelium morphology (HP:0012253)1.64663692
148Abnormal respiratory motile cilium morphology (HP:0005938)1.64663692
149Delayed myelination (HP:0012448)1.64635011
150Unsteady gait (HP:0002317)1.64231467
151Embryonal renal neoplasm (HP:0011794)1.64216499
152Ectopic kidney (HP:0000086)1.63917866
153Esotropia (HP:0000565)1.63901640
154Delusions (HP:0000746)1.63440925
155Clubbing of toes (HP:0100760)1.63431641
156Small intestinal stenosis (HP:0012848)1.62528805
157Duodenal stenosis (HP:0100867)1.62528805
158Abnormality of the septum pellucidum (HP:0007375)1.62217329
159Preaxial hand polydactyly (HP:0001177)1.61548690
160Broad foot (HP:0001769)1.61501712

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK5.77802287
2MAP3K123.46144488
3BCR3.09621074
4TRIM283.08256371
5INSRR3.01369767
6MUSK2.90704704
7MAP2K72.88935416
8TSSK62.88485837
9STK162.74534675
10CCNB12.69247217
11AKT32.47101419
12FRK2.46956147
13NUAK12.38265256
14DAPK12.16714810
15SRPK12.05114022
16SIK31.99006059
17MAP4K21.96599360
18VRK21.92729936
19BUB11.88461433
20MAP3K41.87378673
21CDK191.84256843
22VRK11.82047412
23NTRK31.70121835
24PLK21.69071446
25TNIK1.68701796
26TTK1.64223681
27NEK11.63115211
28TXK1.59173270
29BMPR21.56477866
30MAPK131.53930494
31WEE11.52567982
32ADRBK21.46754975
33MST41.40043713
34ZAK1.39547315
35CDK81.39541785
36MKNK11.39423226
37PLK41.37594882
38EIF2AK11.36900076
39ACVR1B1.35952708
40CAMKK21.34177408
41WNK31.33169669
42MYLK1.31479160
43YES11.28720077
44CDC71.22825508
45PLK31.21473379
46CSNK1G11.18776707
47BRAF1.18591789
48MKNK21.18526038
49PRKD31.15779143
50EIF2AK31.13943026
51PNCK1.10040987
52PINK11.07498151
53PAK31.05177622
54KIT0.96769228
55EPHA40.96590540
56RIPK40.94882553
57CSNK1A1L0.93977480
58EIF2AK20.93273071
59NEK60.92899355
60TAOK30.92814096
61GRK50.88932114
62SGK20.88542461
63BCKDK0.85511703
64BMPR1B0.84654040
65ATM0.83430240
66KSR10.79959124
67MINK10.77692834
68MAPKAPK50.72386616
69ERBB30.71576295
70PLK10.71555986
71MARK30.70137172
72ATR0.69405520
73PIK3CA0.68631195
74MAP3K60.68367960
75NME10.67643845
76BRD40.67087647
77GRK70.66199992
78TNK20.66139870
79MARK10.66110456
80CHEK10.66030893
81BRSK20.64857898
82PRPF4B0.62108951
83DAPK20.61494146
84MAP2K40.59567055
85TAF10.59297778
86ALK0.59207201
87PRKCG0.59097140
88EPHA30.58856155
89NEK20.58306312
90FER0.54883923
91PRKCQ0.54612984
92CAMK2A0.53792530
93TEC0.52810670
94EPHB10.52775420
95SYK0.52742698
96IRAK40.52417626
97CDK30.52154273
98BRSK10.51975344
99ARAF0.51579609
100OXSR10.51283253
101FGFR20.50352878
102TIE10.50175697
103TLK10.49532012
104CHEK20.49393290
105DYRK20.49388413
106MATK0.49199423
107CSNK1G30.48571725
108CSNK2A10.47733087
109SGK4940.47662412
110SGK2230.47662412
111FES0.46788503
112CLK10.45618192
113CDK70.45299356
114PIM20.44372435
115CAMK2B0.43895259
116AURKA0.43406709
117PRKDC0.42514190
118NTRK20.41659864
119CAMK10.38989007
120LYN0.38439954
121CSNK2A20.38171303
122RPS6KB10.37922087
123SIK20.37541891
124CSNK1D0.37527997
125CDK10.36943297
126STK240.36615618
127PRKCE0.35752878
128DYRK1A0.35712734
129MAPK110.35049221
130RAF10.34982821
131NLK0.33781400
132CDK20.33661393
133GRK10.32556671
134CSNK1A10.32482593
135PDK30.32460628
136PDK40.32460628
137ADRBK10.32081584
138CSNK1E0.29904385
139PBK0.27609857
140AURKB0.27273035
141CSNK1G20.27248304
142CDK50.27106783
143CDK180.26271605
144GRK60.25533887
145CSF1R0.25510178
146PDK20.24227936

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030503.34006628
2DNA replication_Homo sapiens_hsa030303.03427171
3Mismatch repair_Homo sapiens_hsa034303.03127080
4RNA polymerase_Homo sapiens_hsa030202.97457568
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.58044766
6Oxidative phosphorylation_Homo sapiens_hsa001902.56960426
7Nicotine addiction_Homo sapiens_hsa050332.53897705
8Homologous recombination_Homo sapiens_hsa034402.39927199
9Parkinsons disease_Homo sapiens_hsa050122.20983706
10Fatty acid elongation_Homo sapiens_hsa000622.18714554
11Non-homologous end-joining_Homo sapiens_hsa034502.16171664
12Nucleotide excision repair_Homo sapiens_hsa034202.16032227
13Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.11946056
14Propanoate metabolism_Homo sapiens_hsa006402.10669108
15Base excision repair_Homo sapiens_hsa034102.08091100
16Collecting duct acid secretion_Homo sapiens_hsa049662.05582102
17RNA degradation_Homo sapiens_hsa030181.98838366
18Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.94829206
19Synaptic vesicle cycle_Homo sapiens_hsa047211.92376734
20Pyrimidine metabolism_Homo sapiens_hsa002401.92125605
21Fanconi anemia pathway_Homo sapiens_hsa034601.91584070
222-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.90008712
23Ribosome_Homo sapiens_hsa030101.89917610
24Spliceosome_Homo sapiens_hsa030401.87526760
25Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.79056213
26Basal transcription factors_Homo sapiens_hsa030221.76631766
27Cysteine and methionine metabolism_Homo sapiens_hsa002701.71826794
28Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.70030061
29Huntingtons disease_Homo sapiens_hsa050161.68870629
30Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.61967056
31Alzheimers disease_Homo sapiens_hsa050101.53712933
32RNA transport_Homo sapiens_hsa030131.51046708
33Purine metabolism_Homo sapiens_hsa002301.48829213
34Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.46498612
35Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.43028066
36Cell cycle_Homo sapiens_hsa041101.39982775
37Pyruvate metabolism_Homo sapiens_hsa006201.38234294
38Steroid biosynthesis_Homo sapiens_hsa001001.34418658
39Olfactory transduction_Homo sapiens_hsa047401.31386327
40Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.31139475
41Protein export_Homo sapiens_hsa030601.28803660
42Morphine addiction_Homo sapiens_hsa050321.24600487
43SNARE interactions in vesicular transport_Homo sapiens_hsa041301.22826580
44Butanoate metabolism_Homo sapiens_hsa006501.20863295
45Serotonergic synapse_Homo sapiens_hsa047261.18045380
46Taste transduction_Homo sapiens_hsa047421.16569907
47Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.13400485
48Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.11947305
49Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.09605936
50Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.08462618
51Fatty acid metabolism_Homo sapiens_hsa012121.07870802
52Vibrio cholerae infection_Homo sapiens_hsa051101.06075851
53Amphetamine addiction_Homo sapiens_hsa050311.05925007
54Circadian entrainment_Homo sapiens_hsa047131.04329101
55Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.02935490
56Selenocompound metabolism_Homo sapiens_hsa004501.01484790
57Biosynthesis of amino acids_Homo sapiens_hsa012301.00460380
58Regulation of autophagy_Homo sapiens_hsa041400.97800337
59GABAergic synapse_Homo sapiens_hsa047270.97463530
60Carbon metabolism_Homo sapiens_hsa012000.95812426
61Oocyte meiosis_Homo sapiens_hsa041140.93408617
62Phototransduction_Homo sapiens_hsa047440.93339252
63Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.91077915
64Long-term potentiation_Homo sapiens_hsa047200.90980442
65Rheumatoid arthritis_Homo sapiens_hsa053230.90187864
66Glutamatergic synapse_Homo sapiens_hsa047240.90187533
67Vitamin B6 metabolism_Homo sapiens_hsa007500.89944912
68Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.89934509
69Primary immunodeficiency_Homo sapiens_hsa053400.86191643
70Type I diabetes mellitus_Homo sapiens_hsa049400.86015581
71Dopaminergic synapse_Homo sapiens_hsa047280.83047593
72Calcium signaling pathway_Homo sapiens_hsa040200.81882599
73mRNA surveillance pathway_Homo sapiens_hsa030150.76072543
74Long-term depression_Homo sapiens_hsa047300.74316252
75Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.72897763
76Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.72381616
77Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.70660863
78Epstein-Barr virus infection_Homo sapiens_hsa051690.69832865
79Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.68934029
80Cardiac muscle contraction_Homo sapiens_hsa042600.68711539
81Autoimmune thyroid disease_Homo sapiens_hsa053200.66561556
82Allograft rejection_Homo sapiens_hsa053300.65527214
83Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.64697842
84Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.62815131
85Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.60019864
86Arginine and proline metabolism_Homo sapiens_hsa003300.58800293
87One carbon pool by folate_Homo sapiens_hsa006700.58401061
88Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.54169399
89Intestinal immune network for IgA production_Homo sapiens_hsa046720.54052766
90Phagosome_Homo sapiens_hsa041450.53874365
91Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.52681969
92Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.52594363
93Alcoholism_Homo sapiens_hsa050340.51617129
94p53 signaling pathway_Homo sapiens_hsa041150.50981743
95Peroxisome_Homo sapiens_hsa041460.49955816
96Sulfur metabolism_Homo sapiens_hsa009200.49896341
97Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.49814791
98Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.48677346
99Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.43293712
100Salivary secretion_Homo sapiens_hsa049700.42677062
101Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.41292477
102Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.41126900
103RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.39421472
104Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.39180681
105Cholinergic synapse_Homo sapiens_hsa047250.38663270
106Antigen processing and presentation_Homo sapiens_hsa046120.37445852
107N-Glycan biosynthesis_Homo sapiens_hsa005100.36121393
108Herpes simplex infection_Homo sapiens_hsa051680.36016999
109Lysine degradation_Homo sapiens_hsa003100.35777602
110Hematopoietic cell lineage_Homo sapiens_hsa046400.34356010
111Oxytocin signaling pathway_Homo sapiens_hsa049210.32707071
112Fructose and mannose metabolism_Homo sapiens_hsa000510.32448195
113Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.31259096
114Asthma_Homo sapiens_hsa053100.30568928
115beta-Alanine metabolism_Homo sapiens_hsa004100.30279823
116Measles_Homo sapiens_hsa051620.29699888
117Renin secretion_Homo sapiens_hsa049240.29583268
118Circadian rhythm_Homo sapiens_hsa047100.27560223
119Fatty acid degradation_Homo sapiens_hsa000710.27394692
120Tryptophan metabolism_Homo sapiens_hsa003800.27382993
121* Metabolic pathways_Homo sapiens_hsa011000.26706938
122Nitrogen metabolism_Homo sapiens_hsa009100.25453804
123Graft-versus-host disease_Homo sapiens_hsa053320.24507656
124Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.24282326
125Cocaine addiction_Homo sapiens_hsa050300.23528873
126Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.23206435
127Colorectal cancer_Homo sapiens_hsa052100.21973353
128Ether lipid metabolism_Homo sapiens_hsa005650.20307606
129Drug metabolism - other enzymes_Homo sapiens_hsa009830.20264513
130Fatty acid biosynthesis_Homo sapiens_hsa000610.19819861
131Folate biosynthesis_Homo sapiens_hsa007900.19624923
132Insulin secretion_Homo sapiens_hsa049110.18387171
133Gap junction_Homo sapiens_hsa045400.18193504
134Melanoma_Homo sapiens_hsa052180.18143757
135Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.17986960
136Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.17557567
137Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.16791476
138Transcriptional misregulation in cancer_Homo sapiens_hsa052020.16527024
139Cyanoamino acid metabolism_Homo sapiens_hsa004600.10026674
140mTOR signaling pathway_Homo sapiens_hsa041500.09611485
141Glutathione metabolism_Homo sapiens_hsa004800.06030115

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