AGGF1P2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein neddylation (GO:0045116)8.38263672
2histone H3-K4 trimethylation (GO:0080182)6.44697298
3negative regulation of type 2 immune response (GO:0002829)6.37553841
4negative regulation of multicellular organism growth (GO:0040015)6.13523558
5cytoplasmic mRNA processing body assembly (GO:0033962)5.96617228
6regulation of establishment of cell polarity (GO:2000114)5.91173386
7regulation of memory T cell differentiation (GO:0043380)5.84316776
8phosphatidylglycerol biosynthetic process (GO:0006655)5.67115503
9regulation of MHC class I biosynthetic process (GO:0045343)5.66584545
10RNA phosphodiester bond hydrolysis, endonucleolytic (GO:0090502)4.74328137
11regulation of interleukin-13 production (GO:0032656)4.58660836
12stress granule assembly (GO:0034063)4.50768834
13regulation of establishment or maintenance of cell polarity (GO:0032878)4.38987907
14hypotonic response (GO:0006971)4.36282179
15dosage compensation (GO:0007549)4.32584507
16peptidyl-lysine trimethylation (GO:0018023)4.32496287
17protein prenylation (GO:0018342)4.22335709
18prenylation (GO:0097354)4.22335709
19Arp2/3 complex-mediated actin nucleation (GO:0034314)4.19377215
20response to redox state (GO:0051775)4.17834679
21negative regulation of norepinephrine secretion (GO:0010700)4.05813321
22cellular response to electrical stimulus (GO:0071257)4.04127997
23cardiolipin metabolic process (GO:0032048)4.02787949
24sequestering of actin monomers (GO:0042989)3.90778330
25sex differentiation (GO:0007548)3.89049887
26positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)3.84648665
27intrinsic apoptotic signaling pathway in response to oxidative stress (GO:0008631)3.66551353
28sterol catabolic process (GO:0016127)3.59405030
29cholesterol catabolic process (GO:0006707)3.59405030
30fibroblast migration (GO:0010761)3.57518151
31parturition (GO:0007567)3.57007070
32positive regulation of transcription initiation from RNA polymerase II promoter (GO:0060261)3.43897872
33hypothalamus development (GO:0021854)3.43164248
34positive regulation of vasculogenesis (GO:2001214)3.42229705
35negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)3.41739677
36alternative mRNA splicing, via spliceosome (GO:0000380)3.38711515
37actin nucleation (GO:0045010)3.33968860
38rRNA catabolic process (GO:0016075)3.33871997
39thrombin receptor signaling pathway (GO:0070493)3.31514293
40regulation of B cell receptor signaling pathway (GO:0050855)3.24290777
41regulation of microtubule depolymerization (GO:0031114)3.23301667
42regulation of interleukin-5 production (GO:0032674)3.21511557
43ADP metabolic process (GO:0046031)3.20917415
44negative regulation of microtubule depolymerization (GO:0007026)3.17383867
45regulation of type 2 immune response (GO:0002828)3.17079789
46embryonic hemopoiesis (GO:0035162)3.16743961
47positive regulation of B cell differentiation (GO:0045579)3.08607261
48positive regulation of DNA-templated transcription, initiation (GO:2000144)3.07064988
49positive regulation of mast cell activation (GO:0033005)3.06367481
50centrosome duplication (GO:0051298)3.04109214
51definitive hemopoiesis (GO:0060216)3.03545489
52regulation of triglyceride catabolic process (GO:0010896)3.03241677
53peptidyl-lysine methylation (GO:0018022)3.02115993
54cerebellar Purkinje cell differentiation (GO:0021702)3.01893939
55protein targeting to lysosome (GO:0006622)3.01840983
56establishment of protein localization to vacuole (GO:0072666)3.01840983
57protein targeting to vacuole (GO:0006623)3.01840983
58negative regulation of erythrocyte differentiation (GO:0045647)2.98532382
59regulation of metalloenzyme activity (GO:0048552)2.97565184
60termination of RNA polymerase III transcription (GO:0006386)2.96762637
61transcription elongation from RNA polymerase III promoter (GO:0006385)2.96762637
62axoneme assembly (GO:0035082)2.96700751
63mitochondrion distribution (GO:0048311)2.96146486
64regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.96081435
65positive regulation of gamma-delta T cell activation (GO:0046645)2.92837857
66regulation of histone H3-K9 methylation (GO:0051570)2.91991139
67regulation of superoxide metabolic process (GO:0090322)2.91229147
68thalamus development (GO:0021794)2.91065372
69forebrain morphogenesis (GO:0048853)2.90670297
70RNA phosphodiester bond hydrolysis (GO:0090501)2.90347421
71phospholipid translocation (GO:0045332)2.87150083
72lipid translocation (GO:0034204)2.87150083
73establishment of nucleus localization (GO:0040023)2.87116254
74adrenergic receptor signaling pathway (GO:0071875)2.86476737
75positive regulation of mast cell degranulation (GO:0043306)2.86024970
76positive regulation of mast cell activation involved in immune response (GO:0033008)2.86024970
77short-chain fatty acid metabolic process (GO:0046459)2.83850648
78cellular response to exogenous dsRNA (GO:0071360)2.82990326
79purine deoxyribonucleotide catabolic process (GO:0009155)2.80631126
80regulation of mast cell activation (GO:0033003)2.80479641
81regulation of histone H3-K4 methylation (GO:0051569)2.77061966
82positive regulation of epidermal growth factor receptor signaling pathway (GO:0045742)2.74508354
83G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.74189486
84negative regulation of catecholamine secretion (GO:0033604)2.74157702
85phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.72139073
86regulation of mast cell activation involved in immune response (GO:0033006)2.71786018
87regulation of RIG-I signaling pathway (GO:0039535)2.71233455
88hepatocyte apoptotic process (GO:0097284)2.70883024
89negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.70693266
90regulation of translational fidelity (GO:0006450)2.68406058
91kynurenine metabolic process (GO:0070189)2.66914829
92response to methylmercury (GO:0051597)2.66556879
93L-serine metabolic process (GO:0006563)2.65779414
94regulation of mast cell degranulation (GO:0043304)2.65511566
95regulation of hypersensitivity (GO:0002883)2.64323562
96phosphatidylglycerol metabolic process (GO:0046471)2.63073246
97positive regulation of granulocyte differentiation (GO:0030854)2.62835277
98response to interferon-beta (GO:0035456)2.62764003
99purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)2.62045437
100negative regulation of T cell mediated immunity (GO:0002710)2.61640171

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse8.84108272
2SCL_19346495_ChIP-Seq_HPC-7_Human5.63795382
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.37914591
4IRF8_22096565_ChIP-ChIP_GC-B_Human4.37130648
5ZNF652_21678463_ChIP-ChIP_ZR75-1_Human4.08506411
6ZNF263_19887448_ChIP-Seq_K562_Human3.25264592
7IRF8_21731497_ChIP-ChIP_J774_Mouse3.22154868
8EZH2_22144423_ChIP-Seq_EOC_Human2.84644819
9CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.76462007
10MEIS1_20887958_ChIP-Seq_HPC-7_Mouse2.41051817
11MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.40201786
12IRF1_19129219_ChIP-ChIP_H3396_Human2.22409273
13VDR_21846776_ChIP-Seq_THP-1_Human2.21544122
14ELF1_17652178_ChIP-ChIP_JURKAT_Human2.12829048
15RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.97570474
16CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.93756663
17VDR_24763502_ChIP-Seq_THP-1_Human1.90120483
18SPI1_23127762_ChIP-Seq_K562_Human1.84756060
19MYB_26560356_Chip-Seq_TH2_Human1.80576503
20SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.76490271
21LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.70986599
22MYC_22102868_ChIP-Seq_BL_Human1.70459506
23IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.70394586
24SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.67415129
25E2F7_22180533_ChIP-Seq_HELA_Human1.66495061
26SPI1_23547873_ChIP-Seq_NB4_Human1.60374185
27TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.51953531
28STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.51235158
29CIITA_25753668_ChIP-Seq_RAJI_Human1.48644262
30GATA1_19941827_ChIP-Seq_MEL_Mouse1.45503192
31GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.44726221
32MYB_26560356_Chip-Seq_TH1_Human1.33770818
33RUNX1_22412390_ChIP-Seq_EML_Mouse1.31876495
34LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.30440949
35GATA3_27048872_Chip-Seq_THYMUS_Human1.28927278
36CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.28767443
37RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.28653714
38SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.28611290
39GATA1_19941826_ChIP-Seq_K562_Human1.26722622
40E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.25691562
41GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.20882373
42ERG_20887958_ChIP-Seq_HPC-7_Mouse1.19330722
43MAF_26560356_Chip-Seq_TH1_Human1.17476362
44NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.16684247
45TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.15377697
46IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.14923406
47ELF1_20517297_ChIP-Seq_JURKAT_Human1.12165741
48MAF_26560356_Chip-Seq_TH2_Human1.11574137
49ER_23166858_ChIP-Seq_MCF-7_Human1.11112717
50SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.10286013
51FLI1_27457419_Chip-Seq_LIVER_Mouse1.09857711
52VDR_22108803_ChIP-Seq_LS180_Human1.08867054
53RXRA_24833708_ChIP-Seq_LIVER_Mouse1.08766067
54SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.08007793
55ETS1_22383799_ChIP-Seq_G1ME_Mouse1.06741518
56FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02318980
57FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.02211951
58BRD4_27068464_Chip-Seq_AML-cells_Mouse1.01910998
59GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.99754929
60EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.99425432
61P300_27268052_Chip-Seq_Bcells_Human0.98415549
62VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.95031507
63VDR_24787735_ChIP-Seq_THP-1_Human0.92838779
64IRF8_27001747_Chip-Seq_BMDM_Mouse0.92377449
65PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.91893603
66TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.91303348
67GATA1_22383799_ChIP-Seq_G1ME_Mouse0.91108483
68NCOR1_26117541_ChIP-Seq_K562_Human0.91004568
69TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.90330599
70ELK1_19687146_ChIP-ChIP_HELA_Human0.89776231
71E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.89352046
72FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.89226048
73GATA2_21666600_ChIP-Seq_HMVEC_Human0.89147263
74GATA3_26560356_Chip-Seq_TH2_Human0.87802484
75STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.86241216
76ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.85639767
77JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.83648550
78RUNX_20019798_ChIP-Seq_JUKART_Human0.82616235
79GATA2_19941826_ChIP-Seq_K562_Human0.81980383
80VDR_23849224_ChIP-Seq_CD4+_Human0.81569640
81HTT_18923047_ChIP-ChIP_STHdh_Human0.81313136
82TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.81129686
83PCGF2_27294783_Chip-Seq_ESCs_Mouse0.80931413
84SALL4_22934838_ChIP-ChIP_CD34+_Human0.79269385
85RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.78940358
86TP53_22573176_ChIP-Seq_HFKS_Human0.78613236
87CTCF_21964334_ChIP-Seq_BJAB-B_Human0.77444158
88GATA3_21878914_ChIP-Seq_MCF-7_Human0.76705107
89KLF4_18555785_ChIP-Seq_MESCs_Mouse0.76662596
90FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.75817011
91GATA2_22383799_ChIP-Seq_G1ME_Mouse0.74581389
92GATA4_21415370_ChIP-Seq_HL-1_Mouse0.72511034
93FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.72067488
94MYC_18358816_ChIP-ChIP_MESCs_Mouse0.71529514
95TFEB_21752829_ChIP-Seq_HELA_Human0.71220517
96SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.70935099
97OCT4_21477851_ChIP-Seq_ESCs_Mouse0.69641269
98STAT4_19710469_ChIP-ChIP_TH1__Mouse0.69499830
99NMYC_18555785_Chip-Seq_ESCs_Mouse0.67956605
100BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.67757273

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002396_abnormal_hematopoietic_system4.44690165
2MP0002009_preneoplasia3.64210284
3MP0001835_abnormal_antigen_presentation3.60100477
4MP0003252_abnormal_bile_duct3.35220105
5MP0004147_increased_porphyrin_level3.21508882
6MP0003172_abnormal_lysosome_physiology2.85797498
7MP0005647_abnormal_sex_gland2.77511370
8MP0000569_abnormal_digit_pigmentation2.64951941
9MP0005464_abnormal_platelet_physiology2.64683497
10MP0003011_delayed_dark_adaptation2.60770925
11MP0002877_abnormal_melanocyte_morpholog2.17735603
12MP0005646_abnormal_pituitary_gland2.13729617
13MP0003186_abnormal_redox_activity2.11407322
14MP0002166_altered_tumor_susceptibility1.99720245
15MP0003806_abnormal_nucleotide_metabolis1.98964690
16MP0003656_abnormal_erythrocyte_physiolo1.84616292
17MP0001545_abnormal_hematopoietic_system1.83774993
18MP0005397_hematopoietic_system_phenotyp1.83774993
19MP0009697_abnormal_copulation1.76978338
20MP0004130_abnormal_muscle_cell1.76305548
21MP0001986_abnormal_taste_sensitivity1.75592672
22MP0002006_tumorigenesis1.68219240
23MP0002822_catalepsy1.66492743
24MP0003638_abnormal_response/metabolism_1.62454536
25MP0001800_abnormal_humoral_immune1.62012773
26MP0000681_abnormal_thyroid_gland1.61709708
27MP0001188_hyperpigmentation1.51850926
28MP0008007_abnormal_cellular_replicative1.46984944
29MP0000427_abnormal_hair_cycle1.42711080
30MP0005671_abnormal_response_to1.41959478
31MP0002723_abnormal_immune_serum1.40955660
32MP0000689_abnormal_spleen_morphology1.38883587
33MP0002095_abnormal_skin_pigmentation1.37537119
34MP0002398_abnormal_bone_marrow1.35393429
35MP0005551_abnormal_eye_electrophysiolog1.34796486
36MP0005000_abnormal_immune_tolerance1.34734845
37MP0002089_abnormal_postnatal_growth/wei1.33662209
38MP0005174_abnormal_tail_pigmentation1.33639414
39MP0005334_abnormal_fat_pad1.33600681
40MP0000465_gastrointestinal_hemorrhage1.32849312
41MP0002452_abnormal_antigen_presenting1.31982578
42MP0001819_abnormal_immune_cell1.28282265
43MP0002722_abnormal_immune_system1.27881466
44MP0002420_abnormal_adaptive_immunity1.27246641
45MP0000371_diluted_coat_color1.26010266
46MP0005025_abnormal_response_to1.20216064
47MP0003763_abnormal_thymus_physiology1.19092551
48MP0000015_abnormal_ear_pigmentation1.18705939
49MP0004808_abnormal_hematopoietic_stem1.17936750
50MP0001919_abnormal_reproductive_system1.17621951
51MP0000358_abnormal_cell_content/1.17246948
52MP0005084_abnormal_gallbladder_morpholo1.15829706
53MP0005220_abnormal_exocrine_pancreas1.15630880
54MP0006035_abnormal_mitochondrial_morpho1.14365953
55MP0002419_abnormal_innate_immunity1.14166128
56MP0005584_abnormal_enzyme/coenzyme_acti1.11754732
57MP0000609_abnormal_liver_physiology1.10048042
58MP0001324_abnormal_eye_pigmentation1.09947745
59MP0004947_skin_inflammation1.08625596
60MP0000716_abnormal_immune_system1.08434177
61MP0004885_abnormal_endolymph1.06023082
62MP0005310_abnormal_salivary_gland1.05838424
63MP0002928_abnormal_bile_duct1.05570547
64MP0000013_abnormal_adipose_tissue1.05019400
65MP0003436_decreased_susceptibility_to1.04685285
66MP0002249_abnormal_larynx_morphology1.02430904
67MP0001661_extended_life_span1.02261943
68MP0000003_abnormal_adipose_tissue1.00449264
69MP0002429_abnormal_blood_cell0.99259358
70MP0008569_lethality_at_weaning0.97421388
71MP0002876_abnormal_thyroid_physiology0.97053640
72MP0000377_abnormal_hair_follicle0.95584480
73MP0002148_abnormal_hypersensitivity_rea0.93763117
74MP0001765_abnormal_ion_homeostasis0.93040796
75MP0000703_abnormal_thymus_morphology0.92354688
76MP0002229_neurodegeneration0.90798811
77MP0004142_abnormal_muscle_tone0.89349684
78MP0005409_darkened_coat_color0.87711946
79MP0004264_abnormal_extraembryonic_tissu0.83397824
80MP0005075_abnormal_melanosome_morpholog0.83364891
81MP0000685_abnormal_immune_system0.82522861
82MP0005636_abnormal_mineral_homeostasis0.82197033
83MP0000367_abnormal_coat/_hair0.81647723
84MP0003866_abnormal_defecation0.80205314
85MP0005410_abnormal_fertilization0.79053392
86MP0002736_abnormal_nociception_after0.78622133
87MP0005365_abnormal_bile_salt0.77666514
88MP0009278_abnormal_bone_marrow0.77341521
89MP0010155_abnormal_intestine_physiology0.76739282
90MP0004043_abnormal_pH_regulation0.76687927
91MP0002177_abnormal_outer_ear0.76383449
92MP0003786_premature_aging0.76287713
93MP0000598_abnormal_liver_morphology0.76110413
94MP0009765_abnormal_xenobiotic_induced0.75955699
95MP0002118_abnormal_lipid_homeostasis0.75536064
96MP0001440_abnormal_grooming_behavior0.74374528
97MP0003329_amyloid_beta_deposits0.73563822
98MP0002405_respiratory_system_inflammati0.73459144
99MP0004185_abnormal_adipocyte_glucose0.72727884
100MP0002019_abnormal_tumor_incidence0.70715465

Predicted human phenotypes

RankGene SetZ-score
1Deep palmar crease (HP:0006191)6.91093887
2Genetic anticipation (HP:0003743)6.77382936
3Acute lymphatic leukemia (HP:0006721)5.63856791
4Dysmetric saccades (HP:0000641)5.34266814
5Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)4.58995280
6Action tremor (HP:0002345)4.29196086
7Progressive cerebellar ataxia (HP:0002073)4.16063402
8Cerebral inclusion bodies (HP:0100314)4.08892879
9Abnormality of the prostate (HP:0008775)4.04736373
10Relative macrocephaly (HP:0004482)3.95628511
11Prostate neoplasm (HP:0100787)3.89182779
12Slow saccadic eye movements (HP:0000514)3.81050161
13Tinnitus (HP:0000360)3.73116825
14Facial cleft (HP:0002006)3.60807459
15Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.57052258
16Constricted visual fields (HP:0001133)3.40068845
17Pheochromocytoma (HP:0002666)3.34462567
18Abnormality of male internal genitalia (HP:0000022)3.31950452
19Capillary hemangiomas (HP:0005306)3.18784647
20Impaired smooth pursuit (HP:0007772)3.18691412
21Abnormality of the hepatic vasculature (HP:0006707)3.17788379
22Prolonged bleeding time (HP:0003010)3.14019988
23Decreased electroretinogram (ERG) amplitude (HP:0000654)3.12958881
24Gingival bleeding (HP:0000225)3.04511118
25Attenuation of retinal blood vessels (HP:0007843)3.00136531
26Fatigue (HP:0012378)2.99974364
27Gaze-evoked nystagmus (HP:0000640)2.96272812
28Central scotoma (HP:0000603)2.95139783
29Limb hypertonia (HP:0002509)2.91276266
30Impaired vibratory sensation (HP:0002495)2.83510572
31Progressive visual loss (HP:0000529)2.82858333
32Neuroendocrine neoplasm (HP:0100634)2.82064136
33Epistaxis (HP:0000421)2.79702659
34Renal cortical cysts (HP:0000803)2.72131864
35Dysdiadochokinesis (HP:0002075)2.70029415
36Hypertensive crisis (HP:0100735)2.61784973
37Abnormality of the heme biosynthetic pathway (HP:0010472)2.61739918
38Hyperglycinemia (HP:0002154)2.60540918
39Acute myeloid leukemia (HP:0004808)2.57648653
40Cerebral hemorrhage (HP:0001342)2.52575701
41Megalencephaly (HP:0001355)2.50364059
42Dyschromatopsia (HP:0007641)2.50319230
43Arterial thrombosis (HP:0004420)2.49144722
44Impulsivity (HP:0100710)2.48707022
45Broad ribs (HP:0000885)2.48601317
46Curly hair (HP:0002212)2.48214656
47Knee flexion contracture (HP:0006380)2.43862438
48Urinary bladder sphincter dysfunction (HP:0002839)2.42624462
49Chest pain (HP:0100749)2.42493803
50Broad-based gait (HP:0002136)2.39577403
51Abnormality of the aortic arch (HP:0012303)2.37808226
52Severe visual impairment (HP:0001141)2.36577281
53Impaired proprioception (HP:0010831)2.34808891
54Pendular nystagmus (HP:0012043)2.30757596
55Abnormality of ocular smooth pursuit (HP:0000617)2.30555689
56Clumsiness (HP:0002312)2.30295474
57Abnormality of cells of the erythroid lineage (HP:0012130)2.29757464
58Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.25806428
59Postural instability (HP:0002172)2.19984213
60Limb ataxia (HP:0002070)2.19482033
61Hip dysplasia (HP:0001385)2.18402707
62Short chin (HP:0000331)2.17591772
63Thrombocytosis (HP:0001894)2.13480477
64Athetosis (HP:0002305)2.13017259
65Abnormality of saccadic eye movements (HP:0000570)2.06800064
66Hyperglycinuria (HP:0003108)2.03472154
67Amaurosis fugax (HP:0100576)2.02326957
68Partial agenesis of the corpus callosum (HP:0001338)2.00487102
69Abnormal number of erythroid precursors (HP:0012131)1.95696387
70Heterotopia (HP:0002282)1.95343651
71Hyperthyroidism (HP:0000836)1.93288176
72Abnormality of the lower motor neuron (HP:0002366)1.89555856
73Chronic obstructive pulmonary disease (HP:0006510)1.89535979
74Obstructive lung disease (HP:0006536)1.89535979
75Polycythemia (HP:0001901)1.86292667
76Tubulointerstitial nephritis (HP:0001970)1.86137572
77Loss of speech (HP:0002371)1.85512630
78Hypochromic microcytic anemia (HP:0004840)1.83530756
79Recurrent bacterial skin infections (HP:0005406)1.83244495
80Myelodysplasia (HP:0002863)1.82168976
81Ankle contracture (HP:0006466)1.81652494
82Amyotrophic lateral sclerosis (HP:0007354)1.81247542
83Postural tremor (HP:0002174)1.80829285
84Aplasia cutis congenita (HP:0001057)1.79896718
85Decreased central vision (HP:0007663)1.76280101
86Absence seizures (HP:0002121)1.76089122
87Recurrent abscess formation (HP:0002722)1.75366112
88Facial hemangioma (HP:0000329)1.73272918
89Vertigo (HP:0002321)1.71362603
903-Methylglutaconic aciduria (HP:0003535)1.71336564
91Abnormality of the thoracic spine (HP:0100711)1.71111305
92Neurofibrillary tangles (HP:0002185)1.69776922
93Acute hepatic failure (HP:0006554)1.69384294
94Neoplasm of the peripheral nervous system (HP:0100007)1.68910820
95Fibular aplasia (HP:0002990)1.66200023
96Failure to thrive in infancy (HP:0001531)1.65919301
97Enlarged kidneys (HP:0000105)1.65661362
98Increased neuronal autofluorescent lipopigment (HP:0002074)1.64679907
99Postnatal microcephaly (HP:0005484)1.64635491
100Microvesicular hepatic steatosis (HP:0001414)1.63816378

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK196.72696151
2KIT3.15229398
3SCYL22.97801225
4MARK12.82311252
5FLT32.77299055
6PBK2.72189364
7AKT32.54757430
8IRAK32.53192591
9MAP3K142.40798086
10TAOK32.33379164
11MAP4K12.25094765
12CSF1R2.22532347
13OXSR12.03545972
14WNK41.95700297
15TEC1.87237398
16FRK1.77978218
17BTK1.70247290
18NME21.70032120
19TXK1.64686439
20SIK21.64283782
21SYK1.62228511
22MAP2K31.60600204
23RPS6KA41.59274365
24TNK21.55818851
25MAP3K61.53400097
26HIPK21.34913463
27CHEK21.28080559
28WNK11.17285533
29RPS6KB21.08784401
30ZAP701.02803561
31MATK1.02211306
32BLK1.00747138
33TBK10.99805904
34RET0.99756780
35LYN0.97177781
36JAK30.97010117
37PIK3CG0.93499813
38BRD40.92555103
39ITK0.91723001
40MAP2K40.88997015
41FES0.79064126
42MAP3K50.79025542
43GRK60.77197965
44SGK30.72940571
45MAP2K70.72728382
46NUAK10.70065097
47DAPK20.68487201
48CDC42BPA0.68011755
49LCK0.67231684
50CDK80.67092326
51STK380.65261946
52MAP2K60.64975569
53BMPR20.64102037
54PDK10.63226265
55FGFR30.62383419
56MAP4K20.61717167
57MAP3K70.61712811
58LIMK10.61621272
59ADRBK20.61052804
60CCNB10.61014574
61PRKCQ0.60284979
62TYK20.59963435
63TRIB30.58345903
64JAK20.53261993
65CDK90.52557428
66BMX0.51930368
67RPS6KA50.51666019
68HCK0.51021087
69MET0.49908349
70MARK20.49861549
71MAPK120.47248239
72IRAK20.47140922
73CDK120.46815753
74MINK10.46364473
75CSNK1D0.45985227
76BMPR1B0.44235346
77PDPK10.44119319
78ATR0.43756341
79EEF2K0.43680992
80RIPK40.43561617
81STK40.43419435
82DAPK10.43168568
83MAP3K130.42833370
84PDGFRA0.42357959
85SGK20.41948886
86CDK40.41078956
87MELK0.41005403
88JAK10.40278551
89TGFBR10.40046135
90MAPK110.39483525
91CDK140.38269201
92MAPKAPK20.37237026
93MARK30.35365366
94CSNK1G10.34223725
95GRK10.33520823
96NEK10.33087804
97ABL20.33046441
98PTK2B0.32658990
99DAPK30.31684079
100BCKDK0.30993754

Predicted pathways (KEGG)

RankGene SetZ-score
1Asthma_Homo sapiens_hsa053103.54798361
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.17555364
3Allograft rejection_Homo sapiens_hsa053302.99153400
4Graft-versus-host disease_Homo sapiens_hsa053322.82495956
5Autoimmune thyroid disease_Homo sapiens_hsa053202.79632285
6Intestinal immune network for IgA production_Homo sapiens_hsa046722.52991583
7Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008602.28041483
8Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.06430247
9Type I diabetes mellitus_Homo sapiens_hsa049402.04441370
10Platelet activation_Homo sapiens_hsa046112.02344364
11Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.83845589
12Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.81624461
13Leishmaniasis_Homo sapiens_hsa051401.70535725
14Non-homologous end-joining_Homo sapiens_hsa034501.65013754
15Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.62936865
16Viral myocarditis_Homo sapiens_hsa054161.56873629
17Herpes simplex infection_Homo sapiens_hsa051681.56106462
18Non-small cell lung cancer_Homo sapiens_hsa052231.53156286
19B cell receptor signaling pathway_Homo sapiens_hsa046621.51886980
20Influenza A_Homo sapiens_hsa051641.50966386
21Other glycan degradation_Homo sapiens_hsa005111.49206812
22Staphylococcus aureus infection_Homo sapiens_hsa051501.47209048
23RNA polymerase_Homo sapiens_hsa030201.46814138
24Acute myeloid leukemia_Homo sapiens_hsa052211.46586502
25Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.43882902
26Glycosaminoglycan degradation_Homo sapiens_hsa005311.42112701
27Olfactory transduction_Homo sapiens_hsa047401.38937734
28Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.35735855
29RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.35518080
30Pancreatic cancer_Homo sapiens_hsa052121.33791281
31Antigen processing and presentation_Homo sapiens_hsa046121.33235826
32Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.30128570
33Toxoplasmosis_Homo sapiens_hsa051451.29521347
34Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.28513612
35Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.25264709
36Hepatitis C_Homo sapiens_hsa051601.17041830
37Basal transcription factors_Homo sapiens_hsa030221.16601043
38Phospholipase D signaling pathway_Homo sapiens_hsa040721.14761699
39mTOR signaling pathway_Homo sapiens_hsa041501.10911812
40Renal cell carcinoma_Homo sapiens_hsa052111.08106719
41Toll-like receptor signaling pathway_Homo sapiens_hsa046201.07321666
42Steroid hormone biosynthesis_Homo sapiens_hsa001401.06569554
43Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.04505606
44Phototransduction_Homo sapiens_hsa047441.03302614
45Fatty acid biosynthesis_Homo sapiens_hsa000610.99873479
46Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.99598004
47Hematopoietic cell lineage_Homo sapiens_hsa046400.91157680
48Tuberculosis_Homo sapiens_hsa051520.87449082
49T cell receptor signaling pathway_Homo sapiens_hsa046600.85844077
50Chronic myeloid leukemia_Homo sapiens_hsa052200.85262246
51SNARE interactions in vesicular transport_Homo sapiens_hsa041300.84756687
52Shigellosis_Homo sapiens_hsa051310.82223539
53Carbohydrate digestion and absorption_Homo sapiens_hsa049730.81517621
54Choline metabolism in cancer_Homo sapiens_hsa052310.80522122
55Epstein-Barr virus infection_Homo sapiens_hsa051690.79414945
56Rheumatoid arthritis_Homo sapiens_hsa053230.78982048
57One carbon pool by folate_Homo sapiens_hsa006700.78372724
58Measles_Homo sapiens_hsa051620.77170711
59Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.74117144
60Jak-STAT signaling pathway_Homo sapiens_hsa046300.73702337
61Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.71845663
62Glioma_Homo sapiens_hsa052140.68411707
63Salivary secretion_Homo sapiens_hsa049700.67028622
64Glycerophospholipid metabolism_Homo sapiens_hsa005640.62820530
65Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.62765899
66Ribosome_Homo sapiens_hsa030100.62083506
67Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.59378757
68Phosphatidylinositol signaling system_Homo sapiens_hsa040700.58722567
69Osteoclast differentiation_Homo sapiens_hsa043800.58182881
70RNA transport_Homo sapiens_hsa030130.56219338
71N-Glycan biosynthesis_Homo sapiens_hsa005100.55551435
72Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.54757063
73NOD-like receptor signaling pathway_Homo sapiens_hsa046210.53269864
74ErbB signaling pathway_Homo sapiens_hsa040120.53143706
75Melanoma_Homo sapiens_hsa052180.51478018
76Primary immunodeficiency_Homo sapiens_hsa053400.50834120
77Small cell lung cancer_Homo sapiens_hsa052220.50691235
78Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.48315732
79Bladder cancer_Homo sapiens_hsa052190.48006940
80Neurotrophin signaling pathway_Homo sapiens_hsa047220.47316489
81Ras signaling pathway_Homo sapiens_hsa040140.46724059
82Pentose and glucuronate interconversions_Homo sapiens_hsa000400.45997264
83Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.42858772
84Chemokine signaling pathway_Homo sapiens_hsa040620.42181751
85VEGF signaling pathway_Homo sapiens_hsa043700.42028449
86Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.41183641
87HTLV-I infection_Homo sapiens_hsa051660.39913537
88Sphingolipid signaling pathway_Homo sapiens_hsa040710.37308347
89Rap1 signaling pathway_Homo sapiens_hsa040150.36896464
90Homologous recombination_Homo sapiens_hsa034400.36311599
91Circadian rhythm_Homo sapiens_hsa047100.36133680
92Regulation of actin cytoskeleton_Homo sapiens_hsa048100.35618029
93Transcriptional misregulation in cancer_Homo sapiens_hsa052020.34000303
94Insulin resistance_Homo sapiens_hsa049310.32936237
95Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.28535973
96Hepatitis B_Homo sapiens_hsa051610.27945097
97Cardiac muscle contraction_Homo sapiens_hsa042600.27636643
98Ether lipid metabolism_Homo sapiens_hsa005650.26715713
99Leukocyte transendothelial migration_Homo sapiens_hsa046700.26306274
100Purine metabolism_Homo sapiens_hsa002300.25397528

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