AGGF1P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902043)8.33306147
2retinal metabolic process (GO:0042574)8.18552799
3lung vasculature development (GO:0060426)7.78934754
4lung morphogenesis (GO:0060425)7.73633591
5platelet dense granule organization (GO:0060155)7.22886161
6activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)7.03572260
7negative regulation of telomere maintenance (GO:0032205)6.78099826
8piRNA metabolic process (GO:0034587)5.96229114
9negative regulation of execution phase of apoptosis (GO:1900118)5.69491302
10histone H3-K36 demethylation (GO:0070544)5.59192221
11heparin biosynthetic process (GO:0030210)5.58299615
12heparin metabolic process (GO:0030202)5.58299615
13regulation of telomere maintenance via telomerase (GO:0032210)5.49168130
14positive regulation of mitochondrial fission (GO:0090141)5.28718050
15retinoic acid metabolic process (GO:0042573)5.02048946
16regulation of histone H3-K27 methylation (GO:0061085)4.96798160
17positive regulation of keratinocyte differentiation (GO:0045618)4.96253378
18ribosomal small subunit assembly (GO:0000028)4.94905637
19endothelial cell morphogenesis (GO:0001886)4.92220921
20mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)4.89748616
21positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021104.89748616
22negative regulation of potassium ion transmembrane transporter activity (GO:1901017)4.69392532
23regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022354.44845229
24negative regulation of keratinocyte proliferation (GO:0010839)4.35877136
25negative regulation of vascular permeability (GO:0043116)4.34899999
26dopamine transport (GO:0015872)4.33385204
27regulation of mitochondrial fission (GO:0090140)4.23693666
28mannosylation (GO:0097502)4.23231900
29regulation of protein polyubiquitination (GO:1902914)4.22370769
30cilium or flagellum-dependent cell motility (GO:0001539)4.20277575
31thyroid hormone generation (GO:0006590)4.12482327
32cellular ketone body metabolic process (GO:0046950)4.11187127
33negative regulation of potassium ion transmembrane transport (GO:1901380)4.05488832
34protein K6-linked ubiquitination (GO:0085020)4.00826350
35L-methionine biosynthetic process from methylthioadenosine (GO:0019509)4.00036711
36lipopolysaccharide biosynthetic process (GO:0009103)3.92647224
37positive regulation of endothelial cell apoptotic process (GO:2000353)3.92382984
38maturation of SSU-rRNA (GO:0030490)3.87077428
39regulation of oxidative stress-induced neuron death (GO:1903203)3.83038338
40DNA methylation involved in gamete generation (GO:0043046)3.83006945
41mitotic cell cycle arrest (GO:0071850)3.80987345
42cellular protein catabolic process (GO:0044257)3.79346998
43phosphorelay signal transduction system (GO:0000160)3.75477168
44regulation of male gonad development (GO:2000018)3.72211729
45ribonucleoprotein complex disassembly (GO:0032988)3.70245084
46opioid receptor signaling pathway (GO:0038003)3.67000377
47regulation of glucokinase activity (GO:0033131)3.63995589
48regulation of hexokinase activity (GO:1903299)3.63995589
49ketone body metabolic process (GO:1902224)3.61024880
50glucocorticoid receptor signaling pathway (GO:0042921)3.55941352
51mitochondrial calcium ion transport (GO:0006851)3.55045285
52negative regulation of histone methylation (GO:0031061)3.51611967
53regulation of telomere maintenance (GO:0032204)3.50015822
54DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.49660200
55regulation of chromatin silencing (GO:0031935)3.45274619
56positive regulation of DNA biosynthetic process (GO:2000573)3.44694787
57negative regulation of systemic arterial blood pressure (GO:0003085)3.40456284
58positive regulation of glomerulus development (GO:0090193)3.40427553
59thyroid hormone metabolic process (GO:0042403)3.39900353
60anterograde synaptic vesicle transport (GO:0048490)3.39082197
61negative regulation of translation, ncRNA-mediated (GO:0040033)3.34312371
62regulation of translation, ncRNA-mediated (GO:0045974)3.34312371
63negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.34312371
64regulation of apoptotic process involved in morphogenesis (GO:1902337)3.30581625
65epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.29760071
66organic cation transport (GO:0015695)3.29390432
67positive regulation of mitochondrial membrane permeability (GO:0035794)3.28626324
68auditory receptor cell differentiation (GO:0042491)3.26374395
69DNA damage response, signal transduction resulting in transcription (GO:0042772)3.24914997
70lipopolysaccharide metabolic process (GO:0008653)3.23477931
71negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)3.21806851
72positive regulation by symbiont of host defense response (GO:0052509)3.19386020
73modulation by symbiont of host defense response (GO:0052031)3.19386020
74modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.19386020
75modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.19386020
76positive regulation by organism of defense response of other organism involved in symbiotic interact3.19386020
77modulation by symbiont of host immune response (GO:0052553)3.19386020
78detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.19291180
79negative regulation of heart growth (GO:0061117)3.19102870
80negative regulation of cardiac muscle tissue growth (GO:0055022)3.19102870
81phagocytosis, recognition (GO:0006910)3.18960160
82negative regulation by host of viral transcription (GO:0043922)3.18238763
83secretory granule organization (GO:0033363)3.11463823
84amino acid salvage (GO:0043102)3.11352445
85L-methionine salvage (GO:0071267)3.11352445
86L-methionine biosynthetic process (GO:0071265)3.11352445
87regulation of type B pancreatic cell apoptotic process (GO:2000674)3.08183859
88ribosomal small subunit biogenesis (GO:0042274)3.04577077
89negative regulation of cytosolic calcium ion concentration (GO:0051481)3.02982994
90positive regulation of epidermal cell differentiation (GO:0045606)3.01414138
91negative regulation of DNA binding (GO:0043392)3.00907618
92lateral sprouting from an epithelium (GO:0060601)2.95926538
93protein localization to cell surface (GO:0034394)2.95433948
94endoderm formation (GO:0001706)2.90845080
95viral transcription (GO:0019083)2.90217209
96regulation of endothelial cell apoptotic process (GO:2000351)2.89685417
97cellular response to interferon-beta (GO:0035458)2.88835887
98megakaryocyte development (GO:0035855)2.87498959
99negative regulation of sodium ion transport (GO:0010766)2.87136652
100drug catabolic process (GO:0042737)2.81753481

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RBPJ_22232070_ChIP-Seq_NCS_Mouse5.13190015
2HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.08347637
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.93937620
4DMRT1_21621532_ChIP-ChIP_FETAL_Ovary3.60860207
5EZH2_22144423_ChIP-Seq_EOC_Human3.57740771
6GATA1_22025678_ChIP-Seq_K562_Human2.87699689
7CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.87009642
8NOTCH1_21737748_ChIP-Seq_TLL_Human2.53066399
9FUS_26573619_Chip-Seq_HEK293_Human2.40568477
10IRF1_19129219_ChIP-ChIP_H3396_Human2.36086733
11CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.33000355
12FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.18795262
13VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.18337825
14GLI1_17442700_ChIP-ChIP_MESCs_Mouse12.9775072
15VDR_22108803_ChIP-Seq_LS180_Human1.98317652
16ESR1_15608294_ChIP-ChIP_MCF-7_Human1.92273741
17IRF8_22096565_ChIP-ChIP_GC-B_Human1.91902025
18EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.90525840
19CDX2_20551321_ChIP-Seq_CACO-2_Human1.85236365
20STAT6_21828071_ChIP-Seq_BEAS2B_Human1.68026004
21HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.55494715
22ER_23166858_ChIP-Seq_MCF-7_Human1.53850870
23AR_20517297_ChIP-Seq_VCAP_Human1.50956278
24SALL1_21062744_ChIP-ChIP_HESCs_Human1.50356339
25SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human1.46967192
26PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.46926144
27TCF4_18268006_ChIP-ChIP_LS174T_Human1.43048950
28ERG_20517297_ChIP-Seq_VCAP_Human1.35022325
29IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.32963916
30TP63_19390658_ChIP-ChIP_HaCaT_Human1.32477569
31NANOG_19829295_ChIP-Seq_ESCs_Human1.30904478
32SOX2_19829295_ChIP-Seq_ESCs_Human1.30904478
33P53_22127205_ChIP-Seq_FIBROBLAST_Human1.30413110
34ELF1_20517297_ChIP-Seq_JURKAT_Human1.30302332
35ZNF274_21170338_ChIP-Seq_K562_Hela1.30278540
36TDRD3_21172665_ChIP-Seq_MCF-7_Human1.23539666
37FOXP3_21729870_ChIP-Seq_TREG_Human1.17948470
38GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.16455815
39ELF5_23300383_ChIP-Seq_T47D_Human1.13100818
40PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.12347461
41PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.10901399
42P300_19829295_ChIP-Seq_ESCs_Human1.10692998
43ESR1_20079471_ChIP-ChIP_T-47D_Human1.08150695
44GABP_17652178_ChIP-ChIP_JURKAT_Human1.07900018
45GATA3_26560356_Chip-Seq_TH2_Human1.07564344
46YY1_22570637_ChIP-Seq_MALME-3M_Human1.07158687
47TP53_22573176_ChIP-Seq_HFKS_Human1.05979736
48EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.05652268
49CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.05075336
50CTBP1_25329375_ChIP-Seq_LNCAP_Human1.05056125
51POU3F2_20337985_ChIP-ChIP_501MEL_Human1.04071311
52MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.00153156
53GATA3_21878914_ChIP-Seq_MCF-7_Human0.99665048
54NANOG_16153702_ChIP-ChIP_HESCs_Human0.94999060
55SOX2_16153702_ChIP-ChIP_HESCs_Human0.94076592
56AR_21572438_ChIP-Seq_LNCaP_Human0.94018581
57FOXA1_27270436_Chip-Seq_PROSTATE_Human0.93785622
58FOXA1_25329375_ChIP-Seq_VCAP_Human0.93785622
59SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.91476618
60P300_27268052_Chip-Seq_Bcells_Human0.90858441
61VDR_23849224_ChIP-Seq_CD4+_Human0.88431156
62FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.87977902
63HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.87617568
64MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.87310584
65VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.86243712
66NANOG_18555785_ChIP-Seq_MESCs_Mouse0.82675200
67NR3C1_21868756_ChIP-Seq_MCF10A_Human0.82440104
68EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.80758539
69CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.80046843
70P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.78553493
71AR_25329375_ChIP-Seq_VCAP_Human0.78128601
72ERA_21632823_ChIP-Seq_H3396_Human0.78021642
73PIAS1_25552417_ChIP-Seq_VCAP_Human0.76830445
74CTCF_21964334_ChIP-Seq_BJAB-B_Human0.76741428
75TP53_22127205_ChIP-Seq_IMR90_Human0.76422927
76FOXA1_21572438_ChIP-Seq_LNCaP_Human0.75604040
77EWS_26573619_Chip-Seq_HEK293_Human0.75361926
78E2F1_20622854_ChIP-Seq_HELA_Human0.74041262
79P53_21459846_ChIP-Seq_SAOS-2_Human0.73860858
80TAF15_26573619_Chip-Seq_HEK293_Human0.73628669
81GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.73310138
82ZFP57_27257070_Chip-Seq_ESCs_Mouse0.73286459
83DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.71183375
84LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.71167378
85TOP2B_26459242_ChIP-Seq_MCF-7_Human0.70852132
86HTT_18923047_ChIP-ChIP_STHdh_Human0.70806319
87ETS1_20019798_ChIP-Seq_JURKAT_Human0.69674097
88STAT3_23295773_ChIP-Seq_U87_Human0.69610220
89MYC_18940864_ChIP-ChIP_HL60_Human0.69489439
90BCOR_27268052_Chip-Seq_Bcells_Human0.69019435
91AHR_22903824_ChIP-Seq_MCF-7_Human0.68846945
92PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.67534230
93ETV2_25802403_ChIP-Seq_MESCs_Mouse0.66326212
94SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.65336559
95ESR1_21235772_ChIP-Seq_MCF-7_Human0.64960619
96AUTS2_25519132_ChIP-Seq_293T-REX_Human0.64939962
97RXR_22108803_ChIP-Seq_LS180_Human0.64359884
98FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.63628335
99FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.62606026
100MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.61871429

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation4.65288926
2MP0001986_abnormal_taste_sensitivity4.30944687
3MP0009379_abnormal_foot_pigmentation4.11962924
4MP0003136_yellow_coat_color3.61680332
5MP0002277_abnormal_respiratory_mucosa3.35007289
6MP0000015_abnormal_ear_pigmentation3.24531379
7MP0001764_abnormal_homeostasis3.14253478
8MP0002653_abnormal_ependyma_morphology3.07784354
9MP0001968_abnormal_touch/_nociception2.97090418
10MP0002132_abnormal_respiratory_system2.88296208
11MP0005645_abnormal_hypothalamus_physiol2.82515269
12MP0002928_abnormal_bile_duct2.79618508
13MP0005646_abnormal_pituitary_gland2.72253435
14MP0005174_abnormal_tail_pigmentation2.58425114
15MP0002736_abnormal_nociception_after2.48873082
16MP0002876_abnormal_thyroid_physiology2.19947569
17MP0000537_abnormal_urethra_morphology2.11794087
18MP0000566_synostosis2.11629979
19MP0003942_abnormal_urinary_system2.04300610
20MP0002095_abnormal_skin_pigmentation2.02790583
21MP0005167_abnormal_blood-brain_barrier2.02436835
22MP0001486_abnormal_startle_reflex1.91423387
23MP0009053_abnormal_anal_canal1.83738869
24MP0003646_muscle_fatigue1.79384931
25MP0000678_abnormal_parathyroid_gland1.77662651
26MP0003828_pulmonary_edema1.73844986
27MP0009278_abnormal_bone_marrow1.70804295
28MP0002160_abnormal_reproductive_system1.70179517
29MP0005389_reproductive_system_phenotype1.69987134
30MP0006292_abnormal_olfactory_placode1.61407710
31MP0008872_abnormal_physiological_respon1.60753509
32MP0003938_abnormal_ear_development1.52902987
33MP0008875_abnormal_xenobiotic_pharmacok1.48628011
34MP0002282_abnormal_trachea_morphology1.40599336
35MP0000467_abnormal_esophagus_morphology1.39414770
36MP0001485_abnormal_pinna_reflex1.39303788
37MP0003279_aneurysm1.32687152
38MP0003943_abnormal_hepatobiliary_system1.30349814
39MP0001293_anophthalmia1.29810704
40MP0001853_heart_inflammation1.26694272
41MP0000569_abnormal_digit_pigmentation1.25194602
42MP0003880_abnormal_central_pattern1.20512519
43MP0004130_abnormal_muscle_cell1.16243169
44MP0002272_abnormal_nervous_system1.09906569
45MP0001919_abnormal_reproductive_system1.09842764
46MP0004185_abnormal_adipocyte_glucose1.04901146
47MP0005647_abnormal_sex_gland1.04676711
48MP0003806_abnormal_nucleotide_metabolis1.04543245
49MP0000383_abnormal_hair_follicle1.03960352
50MP0001324_abnormal_eye_pigmentation1.01276670
51MP0001765_abnormal_ion_homeostasis0.98345722
52MP0004145_abnormal_muscle_electrophysio0.97249705
53MP0003567_abnormal_fetal_cardiomyocyte0.95078176
54MP0009745_abnormal_behavioral_response0.94852118
55MP0002098_abnormal_vibrissa_morphology0.94604880
56MP0002733_abnormal_thermal_nociception0.91570400
57MP0002735_abnormal_chemical_nociception0.87676293
58MP0004808_abnormal_hematopoietic_stem0.87364326
59MP0001502_abnormal_circadian_rhythm0.87176287
60MP0001145_abnormal_male_reproductive0.86943511
61MP0003300_gastrointestinal_ulcer0.85148943
62MP0005636_abnormal_mineral_homeostasis0.84846178
63MP0000653_abnormal_sex_gland0.83731407
64MP0008058_abnormal_DNA_repair0.83037718
65MP0001905_abnormal_dopamine_level0.81995185
66MP0002210_abnormal_sex_determination0.81884073
67MP0009333_abnormal_splenocyte_physiolog0.81258257
68MP0003195_calcinosis0.79366969
69MP0003252_abnormal_bile_duct0.79354685
70MP0000631_abnormal_neuroendocrine_gland0.78925509
71MP0001175_abnormal_lung_morphology0.78863829
72MP0004133_heterotaxia0.78256811
73MP0001849_ear_inflammation0.72690091
74MP0004264_abnormal_extraembryonic_tissu0.72401523
75MP0001545_abnormal_hematopoietic_system0.71098914
76MP0005397_hematopoietic_system_phenotyp0.71098914
77MP0010329_abnormal_lipoprotein_level0.67078699
78MP0000049_abnormal_middle_ear0.67027594
79MP0000428_abnormal_craniofacial_morphol0.67027459
80MP0005551_abnormal_eye_electrophysiolog0.66695779
81MP0002127_abnormal_cardiovascular_syste0.65197207
82MP0003632_abnormal_nervous_system0.65085442
83MP0003698_abnormal_male_reproductive0.64820208
84MP0003638_abnormal_response/metabolism_0.64442383
85MP0003122_maternal_imprinting0.63856057
86MP0008775_abnormal_heart_ventricle0.63161815
87MP0010368_abnormal_lymphatic_system0.62616571
88MP0002249_abnormal_larynx_morphology0.62045536
89MP0005195_abnormal_posterior_eye0.61934346
90MP0004215_abnormal_myocardial_fiber0.60563480
91MP0000534_abnormal_ureter_morphology0.57631861
92MP0005464_abnormal_platelet_physiology0.57371385
93MP0000026_abnormal_inner_ear0.56899113
94MP0003186_abnormal_redox_activity0.56869157
95MP0002693_abnormal_pancreas_physiology0.56859261
96MP0003183_abnormal_peptide_metabolism0.55936549
97MP0001756_abnormal_urination0.54964590
98MP0004142_abnormal_muscle_tone0.53168935
99MP0000013_abnormal_adipose_tissue0.52985826
100MP0002572_abnormal_emotion/affect_behav0.50921051

Predicted human phenotypes

RankGene SetZ-score
1Type II lissencephaly (HP:0007260)5.00320011
2Abnormality of cells of the erythroid lineage (HP:0012130)4.58482608
3Supernumerary spleens (HP:0009799)4.33019158
4Abnormal biliary tract physiology (HP:0012439)3.94785706
5Bile duct proliferation (HP:0001408)3.94785706
6Abnormality of the costochondral junction (HP:0000919)3.87186165
7Cerebral hypomyelination (HP:0006808)3.81040213
8Pancreatic cysts (HP:0001737)3.67504406
9Tubulointerstitial nephritis (HP:0001970)3.64995937
10Asplenia (HP:0001746)3.64962941
11Synostosis involving the elbow (HP:0003938)3.63544353
12Humeroradial synostosis (HP:0003041)3.63544353
13Aplasia/Hypoplasia of the spleen (HP:0010451)3.58330766
14Abnormal number of erythroid precursors (HP:0012131)3.53499049
15Tubular atrophy (HP:0000092)3.32463823
16Abnormality of the diencephalon (HP:0010662)3.31496728
17Atonic seizures (HP:0010819)3.11402897
18Pancreatic fibrosis (HP:0100732)3.09368246
19Optic nerve hypoplasia (HP:0000609)3.01978347
20Renal cortical cysts (HP:0000803)2.99593178
21Delayed CNS myelination (HP:0002188)2.95789303
22Flat cornea (HP:0007720)2.89601862
23Aplasia/hypoplasia of the humerus (HP:0006507)2.85511004
24Febrile seizures (HP:0002373)2.83156332
25Retinal dysplasia (HP:0007973)2.81235214
26Enlarged kidneys (HP:0000105)2.79872928
27Cerebellar dysplasia (HP:0007033)2.78607605
28Aplasia/Hypoplasia of the sacrum (HP:0008517)2.77741849
29Abnormality of the proximal phalanges of the hand (HP:0009834)2.75615281
30Fused cervical vertebrae (HP:0002949)2.74899504
31Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.71079271
32Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.69783251
33Elfin facies (HP:0004428)2.69710291
34Absent thumb (HP:0009777)2.62799091
35Abnormality of fatty-acid metabolism (HP:0004359)2.61608348
36Abnormality of the renal cortex (HP:0011035)2.60551449
37Rib fusion (HP:0000902)2.58610202
38Alveolar cell carcinoma (HP:0006519)2.58085966
39Hypochromic anemia (HP:0001931)2.56985566
40Delayed epiphyseal ossification (HP:0002663)2.56326973
41Septo-optic dysplasia (HP:0100842)2.52952489
42Overriding aorta (HP:0002623)2.52113563
43Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.51975352
44Long nose (HP:0003189)2.51952360
45Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.49011086
46Abnormality of alanine metabolism (HP:0010916)2.49011086
47Hyperalaninemia (HP:0003348)2.49011086
48Generalized aminoaciduria (HP:0002909)2.48354656
49Renovascular hypertension (HP:0100817)2.47837181
50Severe muscular hypotonia (HP:0006829)2.44508841
51Abnormality of the middle phalanges of the toes (HP:0010183)2.43939983
52Chorioretinal atrophy (HP:0000533)2.41691600
53Cystic liver disease (HP:0006706)2.36543206
54Absence seizures (HP:0002121)2.34298957
55Symptomatic seizures (HP:0011145)2.32298768
56Personality changes (HP:0000751)2.30200251
57Hyperacusis (HP:0010780)2.30074275
58Status epilepticus (HP:0002133)2.24137440
59Reticulocytopenia (HP:0001896)2.22755357
60Stenosis of the external auditory canal (HP:0000402)2.22301029
61Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.19617018
62Short 1st metacarpal (HP:0010034)2.19617018
63Hypoglycemic coma (HP:0001325)2.18701309
64Partial agenesis of the corpus callosum (HP:0001338)2.17327216
65Short humerus (HP:0005792)2.17125533
66Constricted visual fields (HP:0001133)2.17041320
67Maternal diabetes (HP:0009800)2.16620457
68Renal duplication (HP:0000075)2.16236944
69Neoplasm of the tracheobronchial system (HP:0100552)2.15592873
70Symphalangism affecting the phalanges of the hand (HP:0009773)2.12090921
71Anterior segment dysgenesis (HP:0007700)2.11278993
72Flat capital femoral epiphysis (HP:0003370)2.10336790
73Adrenal hypoplasia (HP:0000835)2.08702566
74Pendular nystagmus (HP:0012043)2.07748663
75Absent/shortened dynein arms (HP:0200106)2.06485559
76Dynein arm defect of respiratory motile cilia (HP:0012255)2.06485559
77Hip dysplasia (HP:0001385)2.06168558
78True hermaphroditism (HP:0010459)2.05650323
79Fibular aplasia (HP:0002990)2.05615678
80Abnormal drinking behavior (HP:0030082)2.05291193
81Polydipsia (HP:0001959)2.05291193
82Congenital stationary night blindness (HP:0007642)2.04940184
83Progressive microcephaly (HP:0000253)2.03040884
84Natal tooth (HP:0000695)2.02867019
85Carpal bone hypoplasia (HP:0001498)2.01168881
86Coarctation of aorta (HP:0001680)2.00554270
87Epileptic encephalopathy (HP:0200134)2.00519576
88Tubulointerstitial abnormality (HP:0001969)2.00210296
89Congenital sensorineural hearing impairment (HP:0008527)2.00051834
90Sclerocornea (HP:0000647)1.99534067
91Abnormal respiratory epithelium morphology (HP:0012253)1.99016440
92Abnormal respiratory motile cilium morphology (HP:0005938)1.99016440
93Unsteady gait (HP:0002317)1.98254763
94Delusions (HP:0000746)1.96795894
95Lissencephaly (HP:0001339)1.96732861
96Esophageal atresia (HP:0002032)1.95308242
97Postnatal microcephaly (HP:0005484)1.94540518
98Cortical visual impairment (HP:0100704)1.94482734
99Supernumerary bones of the axial skeleton (HP:0009144)1.93420829
100Pseudobulbar signs (HP:0002200)1.92892691

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PINK17.57240138
2BRSK25.84069246
3SRPK14.95703144
4WEE14.35514740
5TAOK33.27525723
6ADRBK23.16185582
7DYRK22.84133602
8TIE12.78792201
9WNK42.45342193
10STK392.17691035
11BRSK12.17118199
12ERN12.07959565
13GRK11.96339871
14HIPK21.77747053
15LRRK21.57873053
16MOS1.44844078
17PAK21.31339394
18FLT31.25922005
19ABL21.18083082
20MAP3K51.13437530
21CCNB11.10487760
22GRK71.09067192
23PLK41.06446663
24ADRBK11.03765366
25WNK10.99727847
26VRK20.98947338
27GRK50.98341824
28DAPK20.93191441
29MATK0.92071730
30MAP3K110.90643981
31ARAF0.88211750
32EIF2AK20.86255293
33MAP3K70.85950599
34SYK0.83090622
35MAP3K90.82975711
36CSF1R0.82413658
37MAP3K130.82036155
38NTRK10.79205577
39TEC0.79089135
40CASK0.77396671
41CSNK1A10.75265562
42ITK0.73349957
43MAPK130.71819847
44TGFBR20.70524567
45CAMK10.64793873
46KIT0.63666570
47IGF1R0.62659099
48MAP2K20.61858755
49PIK3CA0.59065326
50MAP4K20.58993229
51PRKAA20.57280492
52DYRK1B0.56331087
53BMPR1B0.52903541
54BTK0.50528463
55PRKCE0.49809980
56VRK10.49543046
57PRKCQ0.48064481
58BCKDK0.46030694
59CSNK1E0.45344919
60MAP2K40.45339835
61PRKCG0.44279069
62BRAF0.43957539
63WNK30.42184426
64BMX0.40622509
65MAPK150.39161213
66MAP4K10.38652595
67LIMK10.36826400
68EPHA40.33117251
69PDK10.32002468
70RPS6KA10.31024382
71IRAK30.30323445
72LCK0.30211164
73PRKCI0.28927514
74PDK20.28509919
75PIM20.28437782
76EGFR0.28119122
77MAP2K70.26645071
78TGFBR10.26554319
79STK100.25922116
80RPS6KB10.25726444
81MAP3K60.25502580
82NUAK10.25354953
83ERBB20.25271779
84MAP3K40.24472162
85RPS6KA60.24062576
86MELK0.23911295
87MAPKAPK50.23416177
88ATR0.22022475
89FRK0.22015258
90PAK30.21296520
91PRKG10.21271873
92TNK20.21204142
93CSNK2A20.20901660
94AKT10.20769634
95MAPK110.20216769
96NME10.19973932
97ABL10.19384463
98PRKCD0.19262159
99PRKCZ0.18788159
100AURKA0.18549882

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur relay system_Homo sapiens_hsa041223.89169498
2One carbon pool by folate_Homo sapiens_hsa006703.54284500
3Sulfur metabolism_Homo sapiens_hsa009203.39484926
4Ribosome_Homo sapiens_hsa030103.21001344
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.93498135
6Non-homologous end-joining_Homo sapiens_hsa034502.90491726
7Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.59911861
8Cyanoamino acid metabolism_Homo sapiens_hsa004602.54284424
9alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.39162594
10Selenocompound metabolism_Homo sapiens_hsa004502.19897329
11Linoleic acid metabolism_Homo sapiens_hsa005912.13973646
12Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.13356281
13Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007602.00497337
14Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.98639793
15Nitrogen metabolism_Homo sapiens_hsa009101.90263335
16Primary bile acid biosynthesis_Homo sapiens_hsa001201.80945871
17Intestinal immune network for IgA production_Homo sapiens_hsa046721.75733792
18Homologous recombination_Homo sapiens_hsa034401.57154348
19Arachidonic acid metabolism_Homo sapiens_hsa005901.49532189
20Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.48725680
21Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.48506281
22Butanoate metabolism_Homo sapiens_hsa006501.45263093
23Parkinsons disease_Homo sapiens_hsa050121.41241002
24Ether lipid metabolism_Homo sapiens_hsa005651.40557990
25Oxidative phosphorylation_Homo sapiens_hsa001901.38001854
26Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.33544520
27Phototransduction_Homo sapiens_hsa047441.29404643
28Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.26784963
29NOD-like receptor signaling pathway_Homo sapiens_hsa046211.26502520
30Autoimmune thyroid disease_Homo sapiens_hsa053201.20677401
31Thyroid hormone synthesis_Homo sapiens_hsa049181.20637439
32Allograft rejection_Homo sapiens_hsa053301.17329507
33Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.13589183
34Rheumatoid arthritis_Homo sapiens_hsa053231.12421659
35Protein export_Homo sapiens_hsa030601.10073829
36Asthma_Homo sapiens_hsa053101.09182412
37Systemic lupus erythematosus_Homo sapiens_hsa053221.07614881
38beta-Alanine metabolism_Homo sapiens_hsa004101.07438700
39Graft-versus-host disease_Homo sapiens_hsa053321.07234005
40Tryptophan metabolism_Homo sapiens_hsa003801.06941288
41Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.03116796
42Rap1 signaling pathway_Homo sapiens_hsa040151.02422256
43Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.01323629
44Spliceosome_Homo sapiens_hsa030400.97124702
45Alzheimers disease_Homo sapiens_hsa050100.93873237
46Type I diabetes mellitus_Homo sapiens_hsa049400.84042642
47Cardiac muscle contraction_Homo sapiens_hsa042600.83794872
48Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.82196428
49Huntingtons disease_Homo sapiens_hsa050160.80954976
50RNA polymerase_Homo sapiens_hsa030200.79459739
51Other glycan degradation_Homo sapiens_hsa005110.76351731
52Drug metabolism - other enzymes_Homo sapiens_hsa009830.75901489
53TGF-beta signaling pathway_Homo sapiens_hsa043500.75469218
54Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.73102538
55Serotonergic synapse_Homo sapiens_hsa047260.71953068
56Pentose and glucuronate interconversions_Homo sapiens_hsa000400.71812128
57Hippo signaling pathway_Homo sapiens_hsa043900.71580731
58Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.71368073
59Fatty acid degradation_Homo sapiens_hsa000710.70718984
60Insulin secretion_Homo sapiens_hsa049110.69699813
61Peroxisome_Homo sapiens_hsa041460.69539515
62Morphine addiction_Homo sapiens_hsa050320.68661458
63RNA transport_Homo sapiens_hsa030130.68327603
64Ras signaling pathway_Homo sapiens_hsa040140.66286662
65Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.65047207
66Notch signaling pathway_Homo sapiens_hsa043300.62884304
67Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.58969653
68Olfactory transduction_Homo sapiens_hsa047400.57734008
69Steroid hormone biosynthesis_Homo sapiens_hsa001400.57475784
70Transcriptional misregulation in cancer_Homo sapiens_hsa052020.56276089
71RNA degradation_Homo sapiens_hsa030180.56141464
72Pyrimidine metabolism_Homo sapiens_hsa002400.55324767
73Arginine and proline metabolism_Homo sapiens_hsa003300.54965937
74Glycerophospholipid metabolism_Homo sapiens_hsa005640.54025025
75Mineral absorption_Homo sapiens_hsa049780.53884594
76Alcoholism_Homo sapiens_hsa050340.52605107
77Melanoma_Homo sapiens_hsa052180.50866900
78N-Glycan biosynthesis_Homo sapiens_hsa005100.50818860
79Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.48260986
80Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.46874928
81RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.46726384
82Vitamin digestion and absorption_Homo sapiens_hsa049770.44373903
83Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.44042625
84Chemical carcinogenesis_Homo sapiens_hsa052040.39591645
85Hematopoietic cell lineage_Homo sapiens_hsa046400.39493064
86Maturity onset diabetes of the young_Homo sapiens_hsa049500.38570433
87Metabolic pathways_Homo sapiens_hsa011000.36434561
88PPAR signaling pathway_Homo sapiens_hsa033200.35644665
89Glutathione metabolism_Homo sapiens_hsa004800.35325217
90Renal cell carcinoma_Homo sapiens_hsa052110.33385702
91Histidine metabolism_Homo sapiens_hsa003400.30631518
92Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.30545538
93Amphetamine addiction_Homo sapiens_hsa050310.30442658
94Aldosterone synthesis and secretion_Homo sapiens_hsa049250.30416815
95Cocaine addiction_Homo sapiens_hsa050300.29866734
96Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.29682684
97Fatty acid elongation_Homo sapiens_hsa000620.29244648
98ABC transporters_Homo sapiens_hsa020100.28153795
99Taste transduction_Homo sapiens_hsa047420.28077799
100ErbB signaling pathway_Homo sapiens_hsa040120.26562078

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