AGAP10P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1acrosome reaction (GO:0007340)9.30111582
2sperm motility (GO:0030317)9.06328574
3fusion of sperm to egg plasma membrane (GO:0007342)7.44598990
4response to pheromone (GO:0019236)7.32605104
5single strand break repair (GO:0000012)6.99255409
6protein polyglutamylation (GO:0018095)6.79024766
7spermatid development (GO:0007286)6.61254490
8multicellular organism reproduction (GO:0032504)6.16174472
9sperm-egg recognition (GO:0035036)5.91834395
10phosphatidylethanolamine biosynthetic process (GO:0006646)5.81962536
11sperm capacitation (GO:0048240)5.70470887
12plasma membrane fusion (GO:0045026)5.64709046
13protein targeting to Golgi (GO:0000042)5.63483562
14phosphatidylethanolamine metabolic process (GO:0046337)5.57799133
15microtubule depolymerization (GO:0007019)5.52772816
16establishment of protein localization to Golgi (GO:0072600)5.41115511
17calcium ion-dependent exocytosis (GO:0017156)5.33361027
18retrograde transport, vesicle recycling within Golgi (GO:0000301)5.22649461
19reproduction (GO:0000003)5.21146311
20binding of sperm to zona pellucida (GO:0007339)5.17790765
21regulation of cilium movement (GO:0003352)5.17523668
22epithelial cilium movement (GO:0003351)5.13948357
23chromosome condensation (GO:0030261)5.03627478
24cell-cell recognition (GO:0009988)5.01018342
25axonemal dynein complex assembly (GO:0070286)4.88611735
26DNA packaging (GO:0006323)4.87927303
27RNA destabilization (GO:0050779)4.69503726
28microtubule polymerization or depolymerization (GO:0031109)4.64488205
29centriole replication (GO:0007099)4.63559968
30cellular ketone body metabolic process (GO:0046950)4.59431322
31spermatogenesis (GO:0007283)4.57087066
32cilium or flagellum-dependent cell motility (GO:0001539)4.55744438
33male gamete generation (GO:0048232)4.55392283
34regulation of ARF GTPase activity (GO:0032312)4.53890232
35spermatid nucleus differentiation (GO:0007289)4.51073680
36microtubule severing (GO:0051013)4.50251982
37motile cilium assembly (GO:0044458)4.40389738
38rRNA methylation (GO:0031167)4.34546352
39single fertilization (GO:0007338)4.32856799
40protein localization to Golgi apparatus (GO:0034067)4.28623220
41centriole assembly (GO:0098534)4.21399808
42cilium movement (GO:0003341)4.18209823
43gamete generation (GO:0007276)4.17247725
44regulation of Rab GTPase activity (GO:0032313)4.08986507
45positive regulation of Rab GTPase activity (GO:0032851)4.08986507
46ketone body metabolic process (GO:1902224)3.95347040
47behavioral response to nicotine (GO:0035095)3.82511133
48seminiferous tubule development (GO:0072520)3.79946744
49negative regulation of organelle assembly (GO:1902116)3.75119928
50organic cation transport (GO:0015695)3.67679764
51coenzyme catabolic process (GO:0009109)3.67197490
52rRNA modification (GO:0000154)3.63409570
53germ cell development (GO:0007281)3.59519887
54epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.57041613
55regulation of microtubule-based movement (GO:0060632)3.53519578
56regulation of sarcomere organization (GO:0060297)3.47928158
57receptor recycling (GO:0001881)3.43165097
58fertilization (GO:0009566)3.41872577
59chromatin silencing (GO:0006342)3.41033835
60regulation of transcription involved in cell fate commitment (GO:0060850)3.40993521
61sexual reproduction (GO:0019953)3.39828826
62cellular process involved in reproduction in multicellular organism (GO:0022412)3.23276799
63axoneme assembly (GO:0035082)3.22228353
64ether metabolic process (GO:0018904)3.20482814
65multicellular organismal reproductive process (GO:0048609)3.17786603
66pyrimidine nucleobase catabolic process (GO:0006208)3.12918175
67regulation of action potential (GO:0098900)3.07340283
68regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.04060943
69male meiosis (GO:0007140)3.04036690
70piRNA metabolic process (GO:0034587)2.99798568
71polyamine biosynthetic process (GO:0006596)2.97605152
72DNA methylation involved in gamete generation (GO:0043046)2.95218230
73cell recognition (GO:0008037)2.94500260
74regulation of centriole replication (GO:0046599)2.93670860
75negative regulation of Rho protein signal transduction (GO:0035024)2.92313477
76detection of chemical stimulus involved in sensory perception of smell (GO:0050911)2.87746820
77response to acidic pH (GO:0010447)2.87175908
78regulation of phosphoprotein phosphatase activity (GO:0043666)2.86058321
79cellular response to pH (GO:0071467)2.85204526
80cell wall macromolecule metabolic process (GO:0044036)2.84704570
81cell wall macromolecule catabolic process (GO:0016998)2.83391466
82spinal cord motor neuron differentiation (GO:0021522)2.78697940
83positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.77343896
84microtubule nucleation (GO:0007020)2.72030508
85locomotory exploration behavior (GO:0035641)2.69530282
86nonmotile primary cilium assembly (GO:0035058)2.68810573
87cerebral cortex radially oriented cell migration (GO:0021799)2.67127671
88negative regulation of gene expression, epigenetic (GO:0045814)2.66625848
89neuronal ion channel clustering (GO:0045161)2.65744929
90negative regulation of inclusion body assembly (GO:0090084)2.64851795
91microtubule bundle formation (GO:0001578)2.62355888
92cilium organization (GO:0044782)2.62144563
93cilium assembly (GO:0042384)2.61694683
94nucleosome disassembly (GO:0006337)2.59963198
95protein-DNA complex disassembly (GO:0032986)2.59963198
96parturition (GO:0007567)2.53081637
97nucleobase catabolic process (GO:0046113)2.51966837
98phenylpropanoid metabolic process (GO:0009698)2.49625933
99DNA double-strand break processing (GO:0000729)2.45150153
100regulation of cilium assembly (GO:1902017)2.44614111

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.79969756
2ZNF274_21170338_ChIP-Seq_K562_Hela3.34679407
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.81105313
4VDR_22108803_ChIP-Seq_LS180_Human2.63764741
5CTBP2_25329375_ChIP-Seq_LNCAP_Human2.57448490
6FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.37702779
7POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.35309484
8TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.35309484
9CTBP1_25329375_ChIP-Seq_LNCAP_Human2.29693471
10IGF1R_20145208_ChIP-Seq_DFB_Human2.21914105
11ER_23166858_ChIP-Seq_MCF-7_Human2.20785882
12MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.18460484
13FUS_26573619_Chip-Seq_HEK293_Human2.05681692
14CBP_20019798_ChIP-Seq_JUKART_Human2.05274647
15IRF4_20064451_ChIP-Seq_CD4+T_Mouse2.05274647
16EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.86213026
17WDR5_24793694_ChIP-Seq_LNCAP_Human1.84038353
18SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.82957774
19GBX2_23144817_ChIP-Seq_PC3_Human1.79748407
20UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.77305428
21NANOG_20526341_ChIP-Seq_ESCs_Human1.75337029
22RAC3_21632823_ChIP-Seq_H3396_Human1.69594388
23NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.63771561
24ERA_21632823_ChIP-Seq_H3396_Human1.62771346
25DROSHA_22980978_ChIP-Seq_HELA_Human1.62008583
26GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.61371241
27TAF15_26573619_Chip-Seq_HEK293_Human1.60181046
28RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.59039563
29EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.59033061
30P300_19829295_ChIP-Seq_ESCs_Human1.57457833
31EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.56681427
32KLF5_20875108_ChIP-Seq_MESCs_Mouse1.56305547
33IRF1_19129219_ChIP-ChIP_H3396_Human1.52880972
34AR_25329375_ChIP-Seq_VCAP_Human1.52664122
35MYC_19829295_ChIP-Seq_ESCs_Human1.51866489
36VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.51385560
37OCT4_20526341_ChIP-Seq_ESCs_Human1.48465573
38TAF2_19829295_ChIP-Seq_ESCs_Human1.47672141
39BCL6_27268052_Chip-Seq_Bcells_Human1.46205263
40GATA3_21878914_ChIP-Seq_MCF-7_Human1.44456400
41CBX2_27304074_Chip-Seq_ESCs_Mouse1.43626038
42SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.43071671
43PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.40902923
44ELF1_20517297_ChIP-Seq_JURKAT_Human1.40555082
45ETV2_25802403_ChIP-Seq_MESCs_Mouse1.39389222
46REST_21632747_ChIP-Seq_MESCs_Mouse1.39171279
47SUZ12_27294783_Chip-Seq_ESCs_Mouse1.37580719
48CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.36349721
49MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.35926272
50BP1_19119308_ChIP-ChIP_Hs578T_Human1.32138446
51PHF8_20622854_ChIP-Seq_HELA_Human1.32054467
52YY1_22570637_ChIP-Seq_MALME-3M_Human1.30810634
53TOP2B_26459242_ChIP-Seq_MCF-7_Human1.30693483
54CTCF_27219007_Chip-Seq_Bcells_Human1.29053382
55TBL1_22424771_ChIP-Seq_293T_Human1.26937336
56EZH2_27294783_Chip-Seq_ESCs_Mouse1.26247224
57E2F1_20622854_ChIP-Seq_HELA_Human1.26181404
58SMAD4_21741376_ChIP-Seq_EPCs_Human1.26075599
59NCOR_22424771_ChIP-Seq_293T_Human1.26032182
60SMAD4_21799915_ChIP-Seq_A2780_Human1.23306524
61NFYB_21822215_ChIP-Seq_K562_Human1.22933778
62TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.22198379
63RUNX2_22187159_ChIP-Seq_PCA_Human1.21711585
64AUTS2_25519132_ChIP-Seq_293T-REX_Human1.21515515
65HNFA_21074721_ChIP-Seq_CACO-2_Human1.20232867
66TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.19811956
67REST_18959480_ChIP-ChIP_MESCs_Mouse1.19226874
68ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.17257989
69GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.16537879
70CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.16510213
71CTCF_20526341_ChIP-Seq_ESCs_Human1.16403075
72TDRD3_21172665_ChIP-Seq_MCF-7_Human1.15733743
73CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.15559984
74P300_27268052_Chip-Seq_Bcells_Human1.14931707
75P53_22127205_ChIP-Seq_FIBROBLAST_Human1.14869445
76ERG_20517297_ChIP-Seq_VCAP_Human1.14669966
77ETV1_20927104_ChIP-Seq_GIST48_Human1.13525683
78EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.13067697
79HOXB7_26014856_ChIP-Seq_BT474_Human1.12071565
80SMAD3_21741376_ChIP-Seq_ESCs_Human1.11647900
81RBPJ_21746931_ChIP-Seq_IB4_Human1.11351391
82ARNT_22903824_ChIP-Seq_MCF-7_Human1.11335285
83GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.10406738
84STAT3_23295773_ChIP-Seq_U87_Human1.10279799
85CBX2_22325352_ChIP-Seq_293T-Rex_Human1.09131854
86SOX2_19829295_ChIP-Seq_ESCs_Human1.08637746
87NANOG_19829295_ChIP-Seq_ESCs_Human1.08637746
88P53_21459846_ChIP-Seq_SAOS-2_Human1.07563167
89AR_21572438_ChIP-Seq_LNCaP_Human1.07380668
90HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.07356122
91SMAD3_21741376_ChIP-Seq_EPCs_Human1.06878847
92PRDM14_20953172_ChIP-Seq_ESCs_Human1.06578442
93PHF8_20622853_ChIP-Seq_HELA_Human1.05996571
94NFYA_21822215_ChIP-Seq_K562_Human1.05295709
95CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.05178469
96SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.03553166
97FOXH1_21741376_ChIP-Seq_ESCs_Human1.02850870
98BMI1_23680149_ChIP-Seq_NPCS_Mouse1.01272636
99SMC4_20622854_ChIP-Seq_HELA_Human1.00254372
100GATA6_21074721_ChIP-Seq_CACO-2_Human0.99874311

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization7.11974809
2MP0006292_abnormal_olfactory_placode3.59919920
3MP0008789_abnormal_olfactory_epithelium3.22670779
4MP0005377_hearing/vestibular/ear_phenot2.95660009
5MP0003878_abnormal_ear_physiology2.95660009
6MP0003698_abnormal_male_reproductive2.94291399
7MP0005499_abnormal_olfactory_system2.85514308
8MP0005394_taste/olfaction_phenotype2.85514308
9MP0001929_abnormal_gametogenesis2.57654353
10MP0005670_abnormal_white_adipose2.37936345
11MP0002102_abnormal_ear_morphology2.34355438
12MP0001485_abnormal_pinna_reflex2.28602850
13MP0001529_abnormal_vocalization2.13594246
14MP0003011_delayed_dark_adaptation1.99475253
15MP0004859_abnormal_synaptic_plasticity1.91768167
16MP0003880_abnormal_central_pattern1.90781487
17MP0001984_abnormal_olfaction1.86810477
18MP0001348_abnormal_lacrimal_gland1.81678074
19MP0001486_abnormal_startle_reflex1.80217175
20MP0004742_abnormal_vestibular_system1.79715228
21MP0005551_abnormal_eye_electrophysiolog1.76707224
22MP0000049_abnormal_middle_ear1.68057616
23MP0005379_endocrine/exocrine_gland_phen1.67437539
24MP0008877_abnormal_DNA_methylation1.66018043
25MP0005423_abnormal_somatic_nervous1.64845362
26MP0001968_abnormal_touch/_nociception1.62705990
27MP0003718_maternal_effect1.61800060
28MP0003950_abnormal_plasma_membrane1.58161992
29MP0002822_catalepsy1.56813048
30MP0002161_abnormal_fertility/fecundity1.55717862
31MP0008995_early_reproductive_senescence1.54121616
32MP0006276_abnormal_autonomic_nervous1.47998977
33MP0002653_abnormal_ependyma_morphology1.46665064
34MP0003646_muscle_fatigue1.44717261
35MP0002210_abnormal_sex_determination1.44375137
36MP0000678_abnormal_parathyroid_gland1.43232241
37MP0003787_abnormal_imprinting1.38441425
38MP0000955_abnormal_spinal_cord1.37016635
39MP0002272_abnormal_nervous_system1.31447051
40MP0002557_abnormal_social/conspecific_i1.31353531
41MP0002733_abnormal_thermal_nociception1.27233259
42MP0005253_abnormal_eye_physiology1.25318837
43MP0000026_abnormal_inner_ear1.24854755
44MP0000749_muscle_degeneration1.16770487
45MP0002234_abnormal_pharynx_morphology1.16096021
46MP0001145_abnormal_male_reproductive1.15805860
47MP0001270_distended_abdomen1.12174804
48MP0002067_abnormal_sensory_capabilities1.12095136
49MP0001963_abnormal_hearing_physiology1.12053679
50MP0002127_abnormal_cardiovascular_syste1.11351175
51MP0002735_abnormal_chemical_nociception1.09571648
52MP0002132_abnormal_respiratory_system1.08599346
53MP0003938_abnormal_ear_development1.08363198
54MP0008775_abnormal_heart_ventricle1.08099313
55MP0002229_neurodegeneration1.07658408
56MP0000653_abnormal_sex_gland1.07285887
57MP0002184_abnormal_innervation1.05097308
58MP0004142_abnormal_muscle_tone1.03816616
59MP0002572_abnormal_emotion/affect_behav1.02271214
60MP0001970_abnormal_pain_threshold0.99773834
61MP0002160_abnormal_reproductive_system0.99544649
62MP0008004_abnormal_stomach_pH0.98739901
63MP0005645_abnormal_hypothalamus_physiol0.96700793
64MP0002736_abnormal_nociception_after0.96198612
65MP0009046_muscle_twitch0.95300291
66MP0006072_abnormal_retinal_apoptosis0.95163463
67MP0002282_abnormal_trachea_morphology0.93624515
68MP0002752_abnormal_somatic_nervous0.92548784
69MP0003635_abnormal_synaptic_transmissio0.92487050
70MP0001905_abnormal_dopamine_level0.92435384
71MP0002837_dystrophic_cardiac_calcinosis0.91832064
72MP0009745_abnormal_behavioral_response0.90637178
73MP0004084_abnormal_cardiac_muscle0.89508161
74MP0004270_analgesia0.87272322
75MP0005083_abnormal_biliary_tract0.87229624
76MP0002249_abnormal_larynx_morphology0.86788392
77MP0000778_abnormal_nervous_system0.84737069
78MP0005084_abnormal_gallbladder_morpholo0.84413860
79MP0001986_abnormal_taste_sensitivity0.83172908
80MP0003879_abnormal_hair_cell0.83051048
81MP0005248_abnormal_Harderian_gland0.82166720
82MP0002882_abnormal_neuron_morphology0.80907558
83MP0001501_abnormal_sleep_pattern0.79520077
84MP0005646_abnormal_pituitary_gland0.78170354
85MP0005391_vision/eye_phenotype0.72003309
86MP0008872_abnormal_physiological_respon0.71259297
87MP0000230_abnormal_systemic_arterial0.71231052
88MP0003122_maternal_imprinting0.68485773
89MP0002063_abnormal_learning/memory/cond0.68129717
90MP0001188_hyperpigmentation0.65136084
91MP0005389_reproductive_system_phenotype0.64508760
92MP0005332_abnormal_amino_acid0.64070387
93MP0001765_abnormal_ion_homeostasis0.63543180
94MP0001764_abnormal_homeostasis0.63108954
95MP0001293_anophthalmia0.60214701
96MP0009115_abnormal_fat_cell0.59230235
97MP0004085_abnormal_heartbeat0.57759955
98MP0004811_abnormal_neuron_physiology0.57599566
99MP0002734_abnormal_mechanical_nocicepti0.57574475
100MP0002269_muscular_atrophy0.57319504

Predicted human phenotypes

RankGene SetZ-score
1Chronic hepatic failure (HP:0100626)4.77078407
2Severe visual impairment (HP:0001141)4.65246462
3Absent/shortened dynein arms (HP:0200106)4.61143967
4Dynein arm defect of respiratory motile cilia (HP:0012255)4.61143967
5Asymmetric septal hypertrophy (HP:0001670)4.45438840
6Tubulointerstitial nephritis (HP:0001970)4.33802751
7Attenuation of retinal blood vessels (HP:0007843)4.09781839
8Bony spicule pigmentary retinopathy (HP:0007737)4.07171457
9Abnormal rod and cone electroretinograms (HP:0008323)3.87954207
10Hypoplasia of the thymus (HP:0000778)3.84135706
11Abnormal ciliary motility (HP:0012262)3.75758045
12Abnormal respiratory motile cilium physiology (HP:0012261)3.45308603
13Abnormal respiratory motile cilium morphology (HP:0005938)3.39856953
14Abnormal respiratory epithelium morphology (HP:0012253)3.39856953
15Retinal dysplasia (HP:0007973)3.23870708
16Resting tremor (HP:0002322)3.20746371
17Hand muscle atrophy (HP:0009130)3.13759820
18Nephronophthisis (HP:0000090)3.11895123
19Infertility (HP:0000789)2.87271675
20Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.83324954
21Male infertility (HP:0003251)2.82376410
22Calf muscle hypertrophy (HP:0008981)2.81569239
23Impulsivity (HP:0100710)2.71108956
24Progressive cerebellar ataxia (HP:0002073)2.64230045
25Abnormality of macular pigmentation (HP:0008002)2.63687255
26Muscle hypertrophy of the lower extremities (HP:0008968)2.62794307
27Exercise-induced myalgia (HP:0003738)2.59032563
28Abnormality of the renal medulla (HP:0100957)2.58662223
29Medial flaring of the eyebrow (HP:0010747)2.58176912
30Polydipsia (HP:0001959)2.53944668
31Abnormal drinking behavior (HP:0030082)2.53944668
32Molar tooth sign on MRI (HP:0002419)2.52069518
33Abnormality of midbrain morphology (HP:0002418)2.52069518
34Hyperkalemia (HP:0002153)2.51746596
35Failure to thrive in infancy (HP:0001531)2.47107288
36Upper limb muscle weakness (HP:0003484)2.39800351
37Myokymia (HP:0002411)2.36531799
38Type 2 muscle fiber atrophy (HP:0003554)2.35564949
39Poor suck (HP:0002033)2.35016098
40True hermaphroditism (HP:0010459)2.33879628
41Type II lissencephaly (HP:0007260)2.31443080
42Exercise-induced muscle cramps (HP:0003710)2.30828474
43Flat capital femoral epiphysis (HP:0003370)2.29650991
44Disproportionate short-trunk short stature (HP:0003521)2.25620245
45Pancreatic cysts (HP:0001737)2.25081224
46Postural instability (HP:0002172)2.24933076
47Keratoconus (HP:0000563)2.23387805
48Increased corneal curvature (HP:0100692)2.23387805
49Abnormality of dental color (HP:0011073)2.22894739
50Abnormality of the aortic arch (HP:0012303)2.20020105
51Optic nerve hypoplasia (HP:0000609)2.18288952
52Hypoplastic ischia (HP:0003175)2.17401213
53Tubulointerstitial abnormality (HP:0001969)2.16165953
54Muscle fiber atrophy (HP:0100295)2.15279631
55Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.13712013
56Inability to walk (HP:0002540)2.11330631
57Pendular nystagmus (HP:0012043)2.10897603
58Abnormal urine output (HP:0012590)2.10221510
59Growth hormone deficiency (HP:0000824)2.10184929
60Upper limb amyotrophy (HP:0009129)2.08585077
61Distal upper limb amyotrophy (HP:0007149)2.08585077
62Pancreatic fibrosis (HP:0100732)2.07217157
63Gait imbalance (HP:0002141)2.07052073
64Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.06622212
65Renal dysplasia (HP:0000110)2.05470143
66Polyuria (HP:0000103)2.05455725
67Myotonia (HP:0002486)2.04591455
68Cerebellar dysplasia (HP:0007033)2.02940785
69Osteomalacia (HP:0002749)2.02782650
70Abnormality of the renal cortex (HP:0011035)2.02542114
71Absent rod-and cone-mediated responses on ERG (HP:0007688)2.02354555
72Abolished electroretinogram (ERG) (HP:0000550)2.02345186
73Congenital primary aphakia (HP:0007707)2.01506718
74Cone-rod dystrophy (HP:0000548)2.01218726
75Occipital encephalocele (HP:0002085)1.99167302
76Congenital malformation of the right heart (HP:0011723)1.98175631
77Double outlet right ventricle (HP:0001719)1.98175631
78Flattened epiphyses (HP:0003071)1.97894585
79Polyphagia (HP:0002591)1.96844267
80Enlarged epiphyses (HP:0010580)1.96532367
81Abnormality of the epiphysis of the femoral head (HP:0010574)1.94313063
82Hyperglycinemia (HP:0002154)1.92076100
83Intellectual disability, moderate (HP:0002342)1.91309493
84Hypophosphatemic rickets (HP:0004912)1.89864485
85Abnormality of renal excretion (HP:0011036)1.88550416
86Stage 5 chronic kidney disease (HP:0003774)1.88255039
87Aplasia/Hypoplasia of the earlobes (HP:0009906)1.84466553
88Abnormality of the femoral head (HP:0003368)1.84214290
89Poor coordination (HP:0002370)1.84182362
90Nephrogenic diabetes insipidus (HP:0009806)1.84066805
91Tubular atrophy (HP:0000092)1.83745367
92Facial shape deformation (HP:0011334)1.83163731
93Potter facies (HP:0002009)1.83163731
94Sclerocornea (HP:0000647)1.82807302
95Prolonged QT interval (HP:0001657)1.82482118
96Hypoplasia of the brainstem (HP:0002365)1.82385217
97Aplasia/Hypoplasia of the brainstem (HP:0007362)1.82385217
98Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.81046777
99Abnormality of the vertebral endplates (HP:0005106)1.80654572
100Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.79921492

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PLK45.77195668
2MAP4K24.97947060
3PINK13.18076676
4INSRR2.66805913
5PRKD32.63309276
6PLK22.35224761
7MAPKAPK52.25280759
8MAP2K72.19035898
9TESK12.04111377
10BMPR1B1.99433982
11DDR21.84369347
12PIK3CG1.81716560
13STK381.70413884
14ADRBK21.68428939
15BCKDK1.68230979
16MAPK131.66410425
17PNCK1.64662546
18MAP3K41.58448671
19CASK1.54441068
20STK38L1.53515532
21DYRK21.39247098
22SIK21.38324624
23BRD41.33200637
24WNK41.32449603
25CDK191.30209529
26CAMK1G1.30050966
27FRK1.26731855
28NTRK31.24452341
29STK161.24021703
30MAP3K91.22756603
31EPHA41.22504210
32CDK81.20714806
33MUSK1.20338024
34DYRK1B1.17174989
35CSNK1G31.14797656
36CSNK1A1L1.14747700
37MAPK151.11587332
38WNK31.07804745
39RPS6KA21.04371422
40DYRK31.03516284
41CSNK1G21.00276504
42PDK10.91574269
43DAPK20.90351770
44PRKCG0.90167191
45ZAK0.88476993
46MARK30.86007087
47MARK10.83601870
48PTK2B0.80071374
49CCNB10.79825123
50NEK60.78394279
51NUAK10.78261057
52CSNK1G10.77556048
53NTRK20.73454037
54GRK10.72249609
55MET0.71951505
56WNK10.71924663
57PDPK10.70478021
58MAP3K70.66403972
59MAP2K20.64450125
60MST1R0.64438086
61PRKAA20.64280749
62PHKG10.61689581
63PHKG20.61689581
64PKN10.61023356
65CDK70.59397418
66PAK30.57814999
67CDK30.56890954
68PRKG10.56692353
69PRKAA10.56619523
70TXK0.54575187
71EEF2K0.54172634
72NEK20.53063818
73RPS6KA10.51996420
74OBSCN0.51916126
75PRKCZ0.51871905
76PRKACB0.48991176
77SGK4940.47300673
78SGK2230.47300673
79CAMK10.47093006
80PRKCQ0.46530163
81MAPKAPK30.45692668
82TYRO30.45510503
83TESK20.45381927
84TNIK0.43198424
85CSNK1D0.42511355
86TIE10.41798654
87PRKG20.40168578
88CSNK1A10.38200303
89RPS6KA50.37525040
90PRKACA0.36547550
91STK390.35450917
92IKBKB0.35248560
93OXSR10.34868118
94TLK10.34271053
95TRIM280.33617523
96PRKCE0.32619872
97EPHB20.31797454
98VRK10.31276856
99MARK20.31234639
100RPS6KA60.30090260

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000726.57479161
2Olfactory transduction_Homo sapiens_hsa047403.48378179
3Butanoate metabolism_Homo sapiens_hsa006503.20721171
4Phototransduction_Homo sapiens_hsa047442.26713967
5Regulation of autophagy_Homo sapiens_hsa041402.06250608
6Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.02925920
7Glycerophospholipid metabolism_Homo sapiens_hsa005641.93916689
8Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.93733036
9Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.92211849
10Fatty acid biosynthesis_Homo sapiens_hsa000611.86086891
11Propanoate metabolism_Homo sapiens_hsa006401.78468192
12Selenocompound metabolism_Homo sapiens_hsa004501.73242744
13Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.72978894
14Nicotine addiction_Homo sapiens_hsa050331.69714938
15Taste transduction_Homo sapiens_hsa047421.63711353
16Fatty acid degradation_Homo sapiens_hsa000711.59738551
17Linoleic acid metabolism_Homo sapiens_hsa005911.57958184
18alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.56665333
19Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.49074779
20Glycerolipid metabolism_Homo sapiens_hsa005611.36212408
21Cardiac muscle contraction_Homo sapiens_hsa042601.35214888
22Basal transcription factors_Homo sapiens_hsa030221.34738311
23Fatty acid metabolism_Homo sapiens_hsa012121.33608594
24Peroxisome_Homo sapiens_hsa041461.33294895
25Ether lipid metabolism_Homo sapiens_hsa005651.33266242
26Maturity onset diabetes of the young_Homo sapiens_hsa049501.32547911
27Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.23377164
28Dorso-ventral axis formation_Homo sapiens_hsa043201.21912144
29beta-Alanine metabolism_Homo sapiens_hsa004101.18994893
30Tryptophan metabolism_Homo sapiens_hsa003801.17903583
31Fanconi anemia pathway_Homo sapiens_hsa034601.17814681
32Sulfur relay system_Homo sapiens_hsa041221.13865807
33Morphine addiction_Homo sapiens_hsa050321.12404546
34Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.09520517
35Circadian entrainment_Homo sapiens_hsa047131.09291298
36Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.09124762
37Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.06463282
38Arginine and proline metabolism_Homo sapiens_hsa003301.04759016
39GABAergic synapse_Homo sapiens_hsa047271.03890374
40Glycosaminoglycan degradation_Homo sapiens_hsa005311.02604190
41Fat digestion and absorption_Homo sapiens_hsa049751.02049311
42Synaptic vesicle cycle_Homo sapiens_hsa047211.01128952
43Collecting duct acid secretion_Homo sapiens_hsa049660.96664296
44Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.95052985
45Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.94273187
46Nitrogen metabolism_Homo sapiens_hsa009100.94207596
47Insulin secretion_Homo sapiens_hsa049110.94095044
48Hedgehog signaling pathway_Homo sapiens_hsa043400.91404391
49Retinol metabolism_Homo sapiens_hsa008300.90496637
50Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.89226082
51Oxidative phosphorylation_Homo sapiens_hsa001900.88931852
52Oocyte meiosis_Homo sapiens_hsa041140.88537593
53Parkinsons disease_Homo sapiens_hsa050120.88007835
54ABC transporters_Homo sapiens_hsa020100.87880341
55Type II diabetes mellitus_Homo sapiens_hsa049300.86731984
56Huntingtons disease_Homo sapiens_hsa050160.84693353
57Phenylalanine metabolism_Homo sapiens_hsa003600.82845772
58Salivary secretion_Homo sapiens_hsa049700.81041862
59Base excision repair_Homo sapiens_hsa034100.77942312
60cAMP signaling pathway_Homo sapiens_hsa040240.77340027
61RNA transport_Homo sapiens_hsa030130.77078335
62Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.76832734
63Glutamatergic synapse_Homo sapiens_hsa047240.75476972
64Dopaminergic synapse_Homo sapiens_hsa047280.74492816
65Type I diabetes mellitus_Homo sapiens_hsa049400.72557808
66Lysine degradation_Homo sapiens_hsa003100.70785113
67Purine metabolism_Homo sapiens_hsa002300.69820225
68Cholinergic synapse_Homo sapiens_hsa047250.63799792
69Chemical carcinogenesis_Homo sapiens_hsa052040.63572033
70Renin secretion_Homo sapiens_hsa049240.63301291
71Calcium signaling pathway_Homo sapiens_hsa040200.62660012
72Serotonergic synapse_Homo sapiens_hsa047260.61317040
73Sphingolipid metabolism_Homo sapiens_hsa006000.59848072
74Metabolic pathways_Homo sapiens_hsa011000.59220641
75Steroid hormone biosynthesis_Homo sapiens_hsa001400.57868332
76Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.57468038
77Carbohydrate digestion and absorption_Homo sapiens_hsa049730.55140623
78Pyruvate metabolism_Homo sapiens_hsa006200.53744798
79RNA degradation_Homo sapiens_hsa030180.53079863
80Endocytosis_Homo sapiens_hsa041440.52728439
81Amphetamine addiction_Homo sapiens_hsa050310.51493182
82Long-term depression_Homo sapiens_hsa047300.50050737
83Oxytocin signaling pathway_Homo sapiens_hsa049210.48839949
84Gastric acid secretion_Homo sapiens_hsa049710.48067521
85Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.45911044
86Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.43581869
87Vascular smooth muscle contraction_Homo sapiens_hsa042700.42908819
88Phagosome_Homo sapiens_hsa041450.41364895
89Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.39127688
90Aldosterone synthesis and secretion_Homo sapiens_hsa049250.38887543
91Arachidonic acid metabolism_Homo sapiens_hsa005900.36018335
92Pancreatic secretion_Homo sapiens_hsa049720.35961954
93Cocaine addiction_Homo sapiens_hsa050300.34812596
94Axon guidance_Homo sapiens_hsa043600.33073138
95Arginine biosynthesis_Homo sapiens_hsa002200.32961110
96Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.30882156
97Gap junction_Homo sapiens_hsa045400.30781661
98Viral myocarditis_Homo sapiens_hsa054160.30736854
99Steroid biosynthesis_Homo sapiens_hsa001000.30420050
100Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.29501906

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