AFM

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the albumin gene family, which is comprised of four genes that localize to chromosome 4 in a tandem arrangement. These four genes encode structurally-related serum transport proteins that are known to be evolutionarily related. The protein encoded by this gene is regulated developmentally, expressed in the liver and secreted into the bloodstream. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1omega-hydroxylase P450 pathway (GO:0097267)9.40478760
2epoxygenase P450 pathway (GO:0019373)9.36909869
3exogenous drug catabolic process (GO:0042738)9.19992422
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.60140966
5L-phenylalanine catabolic process (GO:0006559)7.60140966
6L-phenylalanine metabolic process (GO:0006558)7.26149283
7erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.26149283
8aromatic amino acid family catabolic process (GO:0009074)6.83963006
9drug metabolic process (GO:0017144)6.39293932
10triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.35595047
11tryptophan catabolic process (GO:0006569)6.18944601
12indole-containing compound catabolic process (GO:0042436)6.18944601
13indolalkylamine catabolic process (GO:0046218)6.18944601
14oxidative demethylation (GO:0070989)6.09692455
15kynurenine metabolic process (GO:0070189)6.07022968
16ethanol metabolic process (GO:0006067)6.05820648
17bile acid biosynthetic process (GO:0006699)5.93063262
18tryptophan metabolic process (GO:0006568)5.82482046
19glyoxylate metabolic process (GO:0046487)5.80615959
20negative regulation of fibrinolysis (GO:0051918)5.67295081
21urea metabolic process (GO:0019627)5.63725773
22urea cycle (GO:0000050)5.63725773
23alpha-linolenic acid metabolic process (GO:0036109)5.60954151
24high-density lipoprotein particle remodeling (GO:0034375)5.60121235
25regulation of fibrinolysis (GO:0051917)5.47409988
26peptidyl-glutamic acid carboxylation (GO:0017187)5.42532890
27protein carboxylation (GO:0018214)5.42532890
28cysteine metabolic process (GO:0006534)5.42123164
29regulation of plasminogen activation (GO:0010755)5.34833398
30regulation of protein activation cascade (GO:2000257)5.34336264
31complement activation, alternative pathway (GO:0006957)5.34297856
32sulfur amino acid catabolic process (GO:0000098)5.33464553
33nitrogen cycle metabolic process (GO:0071941)5.18234641
34serine family amino acid catabolic process (GO:0009071)5.15765442
35bile acid metabolic process (GO:0008206)5.10331594
36phenylpropanoid metabolic process (GO:0009698)5.08344508
37regulation of complement activation (GO:0030449)4.97445057
38aromatic amino acid family metabolic process (GO:0009072)4.96725184
39regulation of humoral immune response (GO:0002920)4.91880366
40regulation of cholesterol esterification (GO:0010872)4.89344136
41reverse cholesterol transport (GO:0043691)4.89239674
42fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.86570582
43negative regulation of blood coagulation (GO:0030195)4.84892284
44negative regulation of hemostasis (GO:1900047)4.84892284
45acute-phase response (GO:0006953)4.81162351
46protein-lipid complex remodeling (GO:0034368)4.79943660
47macromolecular complex remodeling (GO:0034367)4.79943660
48plasma lipoprotein particle remodeling (GO:0034369)4.79943660
49tyrosine metabolic process (GO:0006570)4.78782520
50homocysteine metabolic process (GO:0050667)4.76455448
51regulation of triglyceride catabolic process (GO:0010896)4.76202804
52negative regulation of protein activation cascade (GO:2000258)4.72585241
53alpha-amino acid catabolic process (GO:1901606)4.66107648
54lysine catabolic process (GO:0006554)4.65016811
55lysine metabolic process (GO:0006553)4.65016811
56acylglycerol homeostasis (GO:0055090)4.62365641
57triglyceride homeostasis (GO:0070328)4.62365641
58negative regulation of sterol transport (GO:0032372)4.62311502
59negative regulation of cholesterol transport (GO:0032375)4.62311502
60amino-acid betaine metabolic process (GO:0006577)4.60417529
61phospholipid efflux (GO:0033700)4.59465204
62cellular ketone body metabolic process (GO:0046950)4.52136577
63S-adenosylmethionine metabolic process (GO:0046500)4.48084790
64glycine metabolic process (GO:0006544)4.44136806
65disruption of cells of other organism involved in symbiotic interaction (GO:0051818)4.43762110
66killing of cells in other organism involved in symbiotic interaction (GO:0051883)4.43762110
67bile acid and bile salt transport (GO:0015721)4.42589664
68plasma lipoprotein particle clearance (GO:0034381)4.42548992
69negative regulation of coagulation (GO:0050819)4.41142504
70imidazole-containing compound metabolic process (GO:0052803)4.41016566
71indolalkylamine metabolic process (GO:0006586)4.38446861
72negative regulation of wound healing (GO:0061045)4.38388306
73coenzyme catabolic process (GO:0009109)4.34877022
74cellular glucuronidation (GO:0052695)4.30537677
75glutamate metabolic process (GO:0006536)4.29563173
76cellular biogenic amine catabolic process (GO:0042402)4.29126716
77amine catabolic process (GO:0009310)4.29126716
78cellular amino acid catabolic process (GO:0009063)4.28972083
79cholesterol efflux (GO:0033344)4.25414742
80serine family amino acid metabolic process (GO:0009069)4.21711158
81alkaloid metabolic process (GO:0009820)4.19030777
82benzene-containing compound metabolic process (GO:0042537)4.13884071
83ethanol oxidation (GO:0006069)4.11974763
84positive regulation of hemostasis (GO:1900048)4.11379801
85positive regulation of blood coagulation (GO:0030194)4.11379801
86low-density lipoprotein particle remodeling (GO:0034374)4.08943294
87cellular modified amino acid catabolic process (GO:0042219)4.08258630
88positive regulation of heterotypic cell-cell adhesion (GO:0034116)4.06463857
89serine family amino acid biosynthetic process (GO:0009070)4.06314845
90dicarboxylic acid biosynthetic process (GO:0043650)4.04493763
91plasma lipoprotein particle assembly (GO:0034377)4.03613325
92fibrinolysis (GO:0042730)4.02773367
93drug catabolic process (GO:0042737)4.00144588
94aldehyde catabolic process (GO:0046185)3.99106055
95arginine metabolic process (GO:0006525)3.99091018
96hormone catabolic process (GO:0042447)3.95793457
97ketone body metabolic process (GO:1902224)3.91436289
98negative regulation of complement activation (GO:0045916)3.89520192
99blood coagulation, intrinsic pathway (GO:0007597)3.88236430
100glucuronate metabolic process (GO:0019585)3.82436768
101uronic acid metabolic process (GO:0006063)3.82436768
102very-low-density lipoprotein particle assembly (GO:0034379)3.78892427
103phospholipid homeostasis (GO:0055091)3.78214491
104positive regulation of coagulation (GO:0050820)3.77575146
105cofactor catabolic process (GO:0051187)3.77152083
106positive regulation of triglyceride lipase activity (GO:0061365)3.76167335
107positive regulation of lipoprotein lipase activity (GO:0051006)3.76167335
108complement activation, classical pathway (GO:0006958)3.75854322
109carboxylic acid catabolic process (GO:0046395)3.74969959
110organic acid catabolic process (GO:0016054)3.74969959
111cholesterol homeostasis (GO:0042632)3.74691450
112flavonoid metabolic process (GO:0009812)3.74176430
113positive regulation of lipid catabolic process (GO:0050996)3.73897284
114complement activation (GO:0006956)3.73181108
115protein activation cascade (GO:0072376)3.73131513
116regulation of bile acid biosynthetic process (GO:0070857)3.72997685
117short-chain fatty acid metabolic process (GO:0046459)3.72630265
118negative regulation of lipase activity (GO:0060192)3.71255988
119sterol homeostasis (GO:0055092)3.68682481
120regulation of cholesterol homeostasis (GO:2000188)3.67224660
121acetyl-CoA metabolic process (GO:0006084)3.66977717
122plasma lipoprotein particle organization (GO:0071827)3.64522526
123acute inflammatory response (GO:0002526)3.63544591
124protein-lipid complex assembly (GO:0065005)3.61751274
125response to mercury ion (GO:0046689)3.59495936
126cytolysis (GO:0019835)3.59474402
127intestinal cholesterol absorption (GO:0030299)3.57224151
128sodium-independent organic anion transport (GO:0043252)3.56404642
129xenobiotic metabolic process (GO:0006805)3.54415011
130opsonization (GO:0008228)3.54372582
131NAD biosynthetic process (GO:0009435)3.52523352
132regulation of acute inflammatory response (GO:0002673)3.48336373
133regulation of apoptotic cell clearance (GO:2000425)3.44778294
134heme transport (GO:0015886)3.39817613

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse8.41817623
2PPARA_22158963_ChIP-Seq_LIVER_Mouse7.21655752
3EGR1_23403033_ChIP-Seq_LIVER_Mouse7.04664661
4* LXR_22158963_ChIP-Seq_LIVER_Mouse6.51291711
5* FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.14266230
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse5.11859927
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.81088196
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse4.04800553
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse4.03556643
10TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.06693094
11ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.9872674
12HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.99735335
13TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.94377093
14FOXA2_19822575_ChIP-Seq_HepG2_Human1.62605979
15HTT_18923047_ChIP-ChIP_STHdh_Human1.57683652
16CLOCK_20551151_ChIP-Seq_293T_Human1.53373671
17HNF4A_19822575_ChIP-Seq_HepG2_Human1.41839813
18GATA1_22025678_ChIP-Seq_K562_Human1.38086597
19TRIM28_21343339_ChIP-Seq_HEK293_Human1.26185054
20THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.25675682
21RXRA_24833708_ChIP-Seq_LIVER_Mouse1.20000708
22STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.19216883
23STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.16293458
24ESR1_15608294_ChIP-ChIP_MCF-7_Human1.08584611
25IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.04621814
26ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.01239086
27MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.00382372
28PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.97967123
29CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.96910469
30SOX2_27498859_Chip-Seq_STOMACH_Mouse0.92714594
31TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.92450511
32HNFA_21074721_ChIP-Seq_CACO-2_Human0.91542093
33IRF1_19129219_ChIP-ChIP_H3396_Human0.90752704
34PHF8_20622853_ChIP-Seq_HELA_Human0.87978026
35IRF8_22096565_ChIP-ChIP_GC-B_Human0.86921159
36PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.86649046
37NFE2_27457419_Chip-Seq_LIVER_Mouse0.85790251
38RARG_19884340_ChIP-ChIP_MEFs_Mouse0.83596561
39AUTS2_25519132_ChIP-Seq_293T-REX_Human0.83547599
40TP53_18474530_ChIP-ChIP_U2OS_Human0.83398566
41ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.82966603
42GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.82669925
43GATA4_25053715_ChIP-Seq_YYC3_Human0.82247693
44ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.79142352
45NFYA_21822215_ChIP-Seq_K562_Human0.78512802
46KAP1_22055183_ChIP-Seq_ESCs_Mouse0.78087601
47BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.77242626
48GATA6_21074721_ChIP-Seq_CACO-2_Human0.76855918
49PIAS1_25552417_ChIP-Seq_VCAP_Human0.76332016
50SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.76278890
51SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.73991551
52RARA_24833708_ChIP-Seq_LIVER_Mouse0.73491382
53Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.72650894
54ZNF263_19887448_ChIP-Seq_K562_Human0.72231677
55EZH2_27294783_Chip-Seq_NPCs_Mouse0.71045161
56CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.70756153
57SOX2_21211035_ChIP-Seq_LN229_Human0.69181963
58SALL4_18804426_ChIP-ChIP_XEN_Mouse0.68348635
59AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.68139790
60FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.67869823
61ESR2_21235772_ChIP-Seq_MCF-7_Human0.66925269
62CBX2_22325352_ChIP-Seq_293T-Rex_Human0.66438406
63NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.64985905
64NRF2_20460467_ChIP-Seq_MEFs_Mouse0.64952349
65NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.64952349
66ETV2_25802403_ChIP-Seq_MESCs_Mouse0.64739728
67RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.63281525
68RARB_24833708_ChIP-Seq_LIVER_Mouse0.63184736
69SUZ12_27294783_Chip-Seq_NPCs_Mouse0.62089266
70ETV1_20927104_ChIP-Seq_GIST48_Human0.61900316
71BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.61102883
72NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.60950133
73RAD21_21589869_ChIP-Seq_MESCs_Mouse0.60942732
74NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.60033582
75RAC3_21632823_ChIP-Seq_H3396_Human0.59458795
76CRX_20693478_ChIP-Seq_RETINA_Mouse0.58788187
77TCF4_18268006_ChIP-ChIP_LS174T_Human0.57703583
78CEBPB_22108803_ChIP-Seq_LS180_Human0.57438086
79ER_23166858_ChIP-Seq_MCF-7_Human0.55044175
80PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.54704930
81GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.54582851
82OCT4_18555785_Chip-Seq_ESCs_Mouse0.54219230
83NFYB_21822215_ChIP-Seq_K562_Human0.54197835
84EGR1_19032775_ChIP-ChIP_M12_Human0.53874653
85* POU3F2_20337985_ChIP-ChIP_501MEL_Human0.53869808
86FOXA1_25552417_ChIP-Seq_VCAP_Human0.53411021
87LXR_22292898_ChIP-Seq_THP-1_Human0.53186366
88ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.52929768
89OCT4_21477851_ChIP-Seq_ESCs_Mouse0.52676036
90FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.52235723
91PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.52039562
92EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.51837089
93AR_20517297_ChIP-Seq_VCAP_Human0.51588037
94ESRRB_18555785_Chip-Seq_ESCs_Mouse0.51440963
95E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.50991961
96STAT3_1855785_ChIP-Seq_MESCs_Mouse0.50841038
97SOX2_20726797_ChIP-Seq_SW620_Human0.50703457
98DNAJC2_21179169_ChIP-ChIP_NT2_Human0.50626263
99FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.50552144
100ESET_19884257_ChIP-Seq_ESCs_Mouse0.50285490
101* MYC_19915707_ChIP-ChIP_AK7_Human0.49735869
102EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.49716716
103RBPJ_21746931_ChIP-Seq_IB4_Human0.49639190
104RUNX1_27457419_Chip-Seq_LIVER_Mouse0.49602154
105SMAD1_18555785_Chip-Seq_ESCs_Mouse0.49561999
106SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.49484049
107P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.48851730
108STAT1_17558387_ChIP-Seq_HELA_Human0.48844990
109* SPI1_20517297_ChIP-Seq_HL60_Human0.48759224
110SRY_22984422_ChIP-ChIP_TESTIS_Rat0.48749655
111CBP_21632823_ChIP-Seq_H3396_Human0.48326284
112TAF15_26573619_Chip-Seq_HEK293_Human0.47726130
113ESR1_21235772_ChIP-Seq_MCF-7_Human0.46617935
114P53_21459846_ChIP-Seq_SAOS-2_Human0.46133217
115CDX2_20551321_ChIP-Seq_CACO-2_Human0.46120084
116PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.45256500
117FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.44984151
118PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.44156499
119GATA1_19941826_ChIP-Seq_K562_Human0.43287215
120FOXO3_23340844_ChIP-Seq_DLD1_Human0.42553106
121PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.42440597
122ESR1_20079471_ChIP-ChIP_T-47D_Human0.41969068
123GATA1_19941827_ChIP-Seq_MEL_Mouse0.41942256
124TAF2_19829295_ChIP-Seq_ESCs_Human0.41792480
125FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.41262515
126CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.40922444
127BCAT_22108803_ChIP-Seq_LS180_Human0.40804784
128ERG_21242973_ChIP-ChIP_JURKAT_Human0.40744194
129PPAR_26484153_Chip-Seq_NCI-H1993_Human0.40299822
130SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.40140482
131GATA2_19941826_ChIP-Seq_K562_Human0.39930051
132GATA6_25053715_ChIP-Seq_YYC3_Human0.39875114
133STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.37995297
134GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.37407596
135MYC_27129775_Chip-Seq_CORNEA_Mouse0.36782639
136LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.36098454
137SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.35943341
138CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.33917675
139SPI1_26923725_Chip-Seq_HPCs_Mouse0.33836288
140CDX2_22108803_ChIP-Seq_LS180_Human0.33800300
141NCOR_22424771_ChIP-Seq_293T_Human0.33667815
142SOX3_22085726_ChIP-Seq_MUSCLE_Mouse0.32027456

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.32979813
2MP0005360_urolithiasis7.62927654
3MP0005085_abnormal_gallbladder_physiolo6.42013549
4MP0005365_abnormal_bile_salt6.15294518
5MP0008875_abnormal_xenobiotic_pharmacok5.09533646
6MP0003806_abnormal_nucleotide_metabolis4.31614475
7MP0003252_abnormal_bile_duct3.89127520
8MP0010329_abnormal_lipoprotein_level3.59851827
9MP0009840_abnormal_foam_cell3.26833521
10MP0005083_abnormal_biliary_tract3.15771401
11MP0003195_calcinosis2.89166025
12MP0005332_abnormal_amino_acid2.78661962
13MP0001666_abnormal_nutrient_absorption2.60564954
14MP0003191_abnormal_cellular_cholesterol2.29289053
15MP0004019_abnormal_vitamin_homeostasis2.16747335
16MP0000609_abnormal_liver_physiology2.15665387
17MP0002118_abnormal_lipid_homeostasis2.09644464
18MP0002138_abnormal_hepatobiliary_system1.96469746
19MP0003868_abnormal_feces_composition1.88632333
20MP0005319_abnormal_enzyme/_coenzyme1.82438447
21MP0001764_abnormal_homeostasis1.65610184
22MP0009697_abnormal_copulation1.62457196
23MP0005584_abnormal_enzyme/coenzyme_acti1.57719338
24MP0005451_abnormal_body_composition1.42212807
25MP0003011_delayed_dark_adaptation1.35317928
26MP0003186_abnormal_redox_activity1.26337597
27MP0009643_abnormal_urine_homeostasis1.26227121
28MP0003656_abnormal_erythrocyte_physiolo1.22620837
29MP0000598_abnormal_liver_morphology1.17197161
30MP0003705_abnormal_hypodermis_morpholog1.14537639
31MP0005647_abnormal_sex_gland1.14254363
32MP0000604_amyloidosis1.09924298
33MP0009764_decreased_sensitivity_to1.04904389
34MP0002254_reproductive_system_inflammat1.03436361
35MP0009763_increased_sensitivity_to1.01852943
36MP0010368_abnormal_lymphatic_system0.99431255
37MP0005636_abnormal_mineral_homeostasis0.95190473
38MP0008469_abnormal_protein_level0.88750183
39MP0009642_abnormal_blood_homeostasis0.87215204
40MP0005408_hypopigmentation0.86226118
41MP0006036_abnormal_mitochondrial_physio0.82124950
42MP0002282_abnormal_trachea_morphology0.82091855
43MP0001915_intracranial_hemorrhage0.81818484
44MP0005084_abnormal_gallbladder_morpholo0.81209111
45MP0005376_homeostasis/metabolism_phenot0.78886543
46MP0009765_abnormal_xenobiotic_induced0.78097116
47MP0002078_abnormal_glucose_homeostasis0.77725203
48MP0002876_abnormal_thyroid_physiology0.77684182
49MP0005220_abnormal_exocrine_pancreas0.75397348
50MP0005670_abnormal_white_adipose0.72211255
51MP0002971_abnormal_brown_adipose0.71198442
52MP0001661_extended_life_span0.71158869
53MP0005187_abnormal_penis_morphology0.71112325
54MP0005334_abnormal_fat_pad0.68901899
55MP0003879_abnormal_hair_cell0.67774804
56MP0003690_abnormal_glial_cell0.67645938
57MP0004130_abnormal_muscle_cell0.67197147
58MP0005535_abnormal_body_temperature0.67195766
59MP0009053_abnormal_anal_canal0.66122350
60MP0003329_amyloid_beta_deposits0.63968417
61MP0005266_abnormal_metabolism0.63496280
62MP0001756_abnormal_urination0.61409614
63MP0002249_abnormal_larynx_morphology0.60677978
64MP0000639_abnormal_adrenal_gland0.60522142
65MP0009785_altered_susceptibility_to0.59875067
66MP0006035_abnormal_mitochondrial_morpho0.57174974
67MP0005448_abnormal_energy_balance0.55774738
68MP0005464_abnormal_platelet_physiology0.53563323
69MP0005023_abnormal_wound_healing0.52567806
70MP0005395_other_phenotype0.49133053
71MP0002822_catalepsy0.48745600
72MP0002136_abnormal_kidney_physiology0.47948592
73MP0003638_abnormal_response/metabolism_0.47290639
74MP0002928_abnormal_bile_duct0.47203810
75MP0003718_maternal_effect0.45068810
76MP0008874_decreased_physiological_sensi0.45046649
77MP0000566_synostosis0.43510406
78MP0003724_increased_susceptibility_to0.43414856
79MP0008873_increased_physiological_sensi0.43122164
80MP0004782_abnormal_surfactant_physiolog0.43027161
81MP0003436_decreased_susceptibility_to0.42695649
82MP0003953_abnormal_hormone_level0.41182454
83MP0003075_altered_response_to0.40939053
84MP0002837_dystrophic_cardiac_calcinosis0.40310815
85MP0005248_abnormal_Harderian_gland0.39228532
86MP0005166_decreased_susceptibility_to0.37365145
87MP0009672_abnormal_birth_weight0.37231652
88MP0002332_abnormal_exercise_endurance0.36174965
89MP0008872_abnormal_physiological_respon0.36109131
90MP0005666_abnormal_adipose_tissue0.34763251
91MP0006082_CNS_inflammation0.33972036
92MP0004381_abnormal_hair_follicle0.33529648
93MP0000579_abnormal_nail_morphology0.32985734
94MP0002168_other_aberrant_phenotype0.32256460
95MP0000249_abnormal_blood_vessel0.32249298
96MP0009115_abnormal_fat_cell0.31953832
97MP0002796_impaired_skin_barrier0.31623371
98MP0004883_abnormal_blood_vessel0.31366175
99MP0000467_abnormal_esophagus_morphology0.31235343
100MP0000230_abnormal_systemic_arterial0.30992098
101MP0001243_abnormal_dermal_layer0.30674819
102MP0002970_abnormal_white_adipose0.29689445
103MP0001853_heart_inflammation0.29401711
104MP0009384_cardiac_valve_regurgitation0.28847332
105MP0001845_abnormal_inflammatory_respons0.27901008
106MP0001881_abnormal_mammary_gland0.26810678
107MP0001545_abnormal_hematopoietic_system0.26734100
108MP0005397_hematopoietic_system_phenotyp0.26734100
109MP0002132_abnormal_respiratory_system0.24970041
110MP0005164_abnormal_response_to0.24538930
111MP0005058_abnormal_lysosome_morphology0.23054079
112MP0002135_abnormal_kidney_morphology0.22692661
113MP0003959_abnormal_lean_body0.22592001
114MP0001851_eye_inflammation0.21496536
115MP0001986_abnormal_taste_sensitivity0.21313488
116MP0002128_abnormal_blood_circulation0.19839651
117MP0000920_abnormal_myelination0.18736101
118MP0001944_abnormal_pancreas_morphology0.17770978
119MP0005197_abnormal_uvea_morphology0.16778937

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)7.51360580
2Abnormality of aromatic amino acid family metabolism (HP:0004338)7.38787034
3Intrahepatic cholestasis (HP:0001406)7.31976055
4Prolonged partial thromboplastin time (HP:0003645)6.64844485
5Abnormality of monocarboxylic acid metabolism (HP:0010996)6.60812115
6Hypobetalipoproteinemia (HP:0003563)6.46823541
7Xanthomatosis (HP:0000991)6.24706584
8Hyperlipoproteinemia (HP:0010980)5.53798596
9Complement deficiency (HP:0004431)5.32772588
10Joint hemorrhage (HP:0005261)4.88701024
11Hypolipoproteinemia (HP:0010981)4.81729911
12Hyperammonemia (HP:0001987)4.60339671
13Abnormality of the common coagulation pathway (HP:0010990)4.53207491
14Hyperglycinemia (HP:0002154)4.48697878
15Epidermoid cyst (HP:0200040)4.44629672
16Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.39846603
17Ketosis (HP:0001946)4.27504105
18Abnormality of sulfur amino acid metabolism (HP:0004339)4.22175491
19Abnormality of methionine metabolism (HP:0010901)4.18725661
20Abnormality of glutamine family amino acid metabolism (HP:0010902)4.17406900
21Hypoalphalipoproteinemia (HP:0003233)4.16522119
22Fat malabsorption (HP:0002630)4.15404590
23Abnormality of aspartate family amino acid metabolism (HP:0010899)4.09088250
24Hyperglycinuria (HP:0003108)3.98679780
25Abnormality of glycine metabolism (HP:0010895)3.97904864
26Abnormality of serine family amino acid metabolism (HP:0010894)3.97904864
27Abnormality of complement system (HP:0005339)3.88384606
28Hypoglycemic coma (HP:0001325)3.87581022
29Abnormality of the intrinsic pathway (HP:0010989)3.81241200
30Abnormality of pyrimidine metabolism (HP:0004353)3.78390554
31Conjugated hyperbilirubinemia (HP:0002908)3.78202862
32Hypercholesterolemia (HP:0003124)3.63917153
33Hyperbilirubinemia (HP:0002904)3.35047158
34Abnormality of fatty-acid metabolism (HP:0004359)3.32822771
35Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.30127152
36Delayed CNS myelination (HP:0002188)3.16929014
37Steatorrhea (HP:0002570)3.11239495
38Spontaneous abortion (HP:0005268)3.07988388
39Abnormality of nucleobase metabolism (HP:0010932)3.07379167
40Ketoacidosis (HP:0001993)3.07223035
41Abnormality of serum amino acid levels (HP:0003112)3.07040964
42Hepatocellular carcinoma (HP:0001402)2.98167307
43Myocardial infarction (HP:0001658)2.96142557
44Hypochromic microcytic anemia (HP:0004840)2.95937587
45Fair hair (HP:0002286)2.92256126
46Neonatal hypoglycemia (HP:0001998)2.90133082
47Osteomalacia (HP:0002749)2.78553824
48Metabolic acidosis (HP:0001942)2.76404189
49Skin nodule (HP:0200036)2.74412344
50Abnormality of purine metabolism (HP:0004352)2.71873473
51Systemic lupus erythematosus (HP:0002725)2.70493552
52Vascular calcification (HP:0004934)2.64709323
53Lethargy (HP:0001254)2.60269317
54Acanthocytosis (HP:0001927)2.59806826
55Abnormality of dicarboxylic acid metabolism (HP:0010995)2.58852715
56Dicarboxylic aciduria (HP:0003215)2.58852715
57Glomerulonephritis (HP:0000099)2.53368197
58Gout (HP:0001997)2.51319188
59Hypoglycemic seizures (HP:0002173)2.50360868
60Purpura (HP:0000979)2.48595161
61Abnormal gallbladder morphology (HP:0012437)2.45133338
62Spastic diplegia (HP:0001264)2.44656428
63Mitral stenosis (HP:0001718)2.43590479
64Cerebral edema (HP:0002181)2.40843435
65Cholelithiasis (HP:0001081)2.38433930
66Irritability (HP:0000737)2.34741277
67Pulmonary embolism (HP:0002204)2.34711386
68Cardiovascular calcification (HP:0011915)2.34703273
69Neonatal onset (HP:0003623)2.34018170
70Malnutrition (HP:0004395)2.31115614
71Abnormal gallbladder physiology (HP:0012438)2.30324902
72Cholecystitis (HP:0001082)2.30324902
73Recurrent gram-negative bacterial infections (HP:0005420)2.29033999
74Amyloidosis (HP:0011034)2.28654446
75Gingival bleeding (HP:0000225)2.23534019
76Esophageal varix (HP:0002040)2.22749648
77Menorrhagia (HP:0000132)2.19324698
78Pancreatitis (HP:0001733)2.13977364
79Late onset (HP:0003584)2.13561789
80Sensorimotor neuropathy (HP:0007141)2.12768320
81Hyperphosphaturia (HP:0003109)2.12634188
82Thrombophlebitis (HP:0004418)2.11813465
83Enlarged kidneys (HP:0000105)2.11725116
84Vomiting (HP:0002013)2.08056136
85Brushfield spots (HP:0001088)2.07765741
86Generalized aminoaciduria (HP:0002909)2.07553067
87Reduced antithrombin III activity (HP:0001976)2.05480552
88Generalized hypopigmentation of hair (HP:0011358)2.04611422
89Poikilocytosis (HP:0004447)2.03290438
90Hyperinsulinemic hypoglycemia (HP:0000825)2.02774219
91Opisthotonus (HP:0002179)2.02522397
92Hemorrhage of the eye (HP:0011885)2.02187637
93Elevated alkaline phosphatase (HP:0003155)1.99421491
94Abnormality of the gallbladder (HP:0005264)1.98701828
95Rickets (HP:0002748)1.95828077
96Arthropathy (HP:0003040)1.93339000
97Abnormality of iron homeostasis (HP:0011031)1.89426859
98Increased serum ferritin (HP:0003281)1.89087051
99Alkalosis (HP:0001948)1.88998715
100Hypophosphatemic rickets (HP:0004912)1.88652324
101Abnormality of transition element cation homeostasis (HP:0011030)1.87910443
102Hydroxyprolinuria (HP:0003080)1.87098696
103Abnormality of proline metabolism (HP:0010907)1.87098696
104Abnormal cartilage morphology (HP:0002763)1.85277345
105Joint swelling (HP:0001386)1.84582058
106Abnormality of urine glucose concentration (HP:0011016)1.83776500
107Glycosuria (HP:0003076)1.83776500
108Renal cortical cysts (HP:0000803)1.83667442
109Abnormal enzyme/coenzyme activity (HP:0012379)1.83366745
110Abnormality of alkaline phosphatase activity (HP:0004379)1.81604055
111Blue irides (HP:0000635)1.80400932
112Elevated hepatic transaminases (HP:0002910)1.79434218
113Nephritis (HP:0000123)1.79302047
114Abnormality of the Achilles tendon (HP:0005109)1.77758132
115Status epilepticus (HP:0002133)1.77441029
116Gangrene (HP:0100758)1.77206259
117Epistaxis (HP:0000421)1.75061985
118Abnormality of vitamin metabolism (HP:0100508)1.74387833
119Proximal tubulopathy (HP:0000114)1.72185285
120Increased mean platelet volume (HP:0011877)1.72140406
121Abnormal urine phosphate concentration (HP:0012599)1.69794422
122Bifid scrotum (HP:0000048)1.68399262
123Cerebral palsy (HP:0100021)1.63364294
124Abnormal platelet volume (HP:0011876)1.55529506
125Atrioventricular block (HP:0001678)1.53971206
126Reticulocytosis (HP:0001923)1.50744689
127Abnormal biliary tract physiology (HP:0012439)1.49540979
128Bile duct proliferation (HP:0001408)1.49540979

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.18522793
2FGFR44.68973599
3SIK14.68175283
4ERN14.28864755
5TAOK33.15708995
6INSRR3.01564102
7ERBB42.80153732
8PKN22.32074742
9MAP2K42.29038503
10MST1R2.14530274
11PRPF4B2.06217415
12PIK3CG1.97021097
13FLT31.93723614
14MAPK111.84525834
15TRIB31.78787569
16TYK21.73906974
17NTRK31.72287065
18LATS11.64615581
19DAPK21.62382069
20PTK61.50604786
21ABL21.45460423
22FGFR21.39799312
23FRK1.38289260
24WNK31.37985392
25NEK91.37642052
26KDR1.34089225
27JAK21.22786483
28NLK1.22101617
29MAP3K71.20962018
30TNK21.18546051
31FER1.12460267
32PINK11.11606706
33PRKAA21.11591960
34CAMKK21.07048221
35GRK61.04749463
36MAP2K31.03801781
37TBK11.03058719
38JAK11.02469148
39BLK1.01459001
40ERBB21.00232462
41MAP3K100.98642830
42MAP3K140.97253242
43MAPK40.95785318
44MYLK0.94153899
45PRKG10.93412521
46PRKCZ0.91946650
47STK38L0.90532855
48PRKACA0.87393441
49MET0.85818764
50EPHB10.85764622
51MAPK150.84659517
52MAP3K20.82568529
53MAP3K30.82503208
54CDK60.80601710
55TIE10.79348438
56MAPK120.78449654
57PRKACG0.75949545
58EPHA30.75885557
59MAP3K110.74784393
60CAMK1D0.73845962
61DYRK1B0.71933872
62MUSK0.71682491
63CSK0.70964573
64ZAP700.69399402
65GSK3A0.68340812
66PDK20.67818803
67CAMK2G0.66468903
68CSNK1D0.66360626
69PRKAA10.66335131
70SGK30.64155606
71MAP2K60.64061332
72CAMKK10.63694266
73AKT30.62735534
74TGFBR20.62102389
75RIPK10.61893292
76SCYL20.60896323
77KIT0.60657687
78FGFR30.58913398
79IRAK30.57235265
80PTK20.56579293
81RPS6KA30.56465242
82PRKCB0.55821858
83MAPK70.55549215
84CSF1R0.55044444
85IKBKE0.52882692
86PRKACB0.52548310
87SRC0.51694304
88EPHA40.51568448
89PRKCQ0.50603632
90PDPK10.50074922
91SGK10.49224191
92CSNK1G10.48868113
93SGK20.48766495
94GRK10.45607532
95CSNK1E0.45176838
96IGF1R0.44105262
97TAOK20.43298132
98RET0.42726634
99BRSK20.41472295
100MAP3K130.41409563
101MAP3K50.40498533
102CDK40.40116961
103PRKCG0.39734986
104PDGFRA0.39553592
105MAP2K10.39342740
106CSNK2A10.38461710
107ARAF0.38306684
108SGK2230.37618150
109SGK4940.37618150
110ICK0.36802231
111MTOR0.35571104
112PKN10.34684825
113CSNK2A20.34614605
114PBK0.32866219
115MAP3K60.32611068
116CAMK40.32289709
117EGFR0.32269883
118PDK10.31683593
119MAPK30.31078624
120STK160.30128457
121CAMK1G0.27511933
122CSNK1G20.26971725
123MAP3K10.26274447
124PRKCA0.25845489
125IRAK10.24428255
126IRAK20.24007414
127CSNK1G30.23512799
128PDK30.23424339
129PDK40.23424339
130LATS20.22866835
131PIK3CA0.22062380
132PAK30.21545501
133ABL10.20477519

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.46538164
2Nitrogen metabolism_Homo sapiens_hsa009103.63092931
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.40665061
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.33410947
5Arginine biosynthesis_Homo sapiens_hsa002203.04118924
6Complement and coagulation cascades_Homo sapiens_hsa046102.78249409
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.70970183
8Tryptophan metabolism_Homo sapiens_hsa003802.68919422
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.65761410
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.53413912
11Fatty acid degradation_Homo sapiens_hsa000712.48333992
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.40170683
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.28311065
14Butanoate metabolism_Homo sapiens_hsa006502.18522269
15Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.14874886
16Peroxisome_Homo sapiens_hsa041462.06494439
17Chemical carcinogenesis_Homo sapiens_hsa052041.96083354
18Propanoate metabolism_Homo sapiens_hsa006401.95557805
19Steroid hormone biosynthesis_Homo sapiens_hsa001401.93841013
20Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.93371573
21Histidine metabolism_Homo sapiens_hsa003401.91944193
22PPAR signaling pathway_Homo sapiens_hsa033201.84066633
23Fatty acid metabolism_Homo sapiens_hsa012121.81085226
24Staphylococcus aureus infection_Homo sapiens_hsa051501.78824087
25Drug metabolism - other enzymes_Homo sapiens_hsa009831.78536417
26Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.73106007
27beta-Alanine metabolism_Homo sapiens_hsa004101.71794445
28Retinol metabolism_Homo sapiens_hsa008301.71248629
29Caffeine metabolism_Homo sapiens_hsa002321.68549542
30Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.65749373
31Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.65194871
32Selenocompound metabolism_Homo sapiens_hsa004501.58949626
33Phenylalanine metabolism_Homo sapiens_hsa003601.54611746
342-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.51506735
35Bile secretion_Homo sapiens_hsa049761.50818314
36Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.47718754
37Tyrosine metabolism_Homo sapiens_hsa003501.43101879
38Pyruvate metabolism_Homo sapiens_hsa006201.36859068
39Sulfur metabolism_Homo sapiens_hsa009201.36062410
40Fatty acid elongation_Homo sapiens_hsa000621.32128695
41Cysteine and methionine metabolism_Homo sapiens_hsa002701.28694793
42Starch and sucrose metabolism_Homo sapiens_hsa005001.28558482
43Steroid biosynthesis_Homo sapiens_hsa001001.20898927
44ABC transporters_Homo sapiens_hsa020101.20800086
45Folate biosynthesis_Homo sapiens_hsa007901.19986977
46Biosynthesis of amino acids_Homo sapiens_hsa012301.18945058
47Fat digestion and absorption_Homo sapiens_hsa049751.17335170
48Carbon metabolism_Homo sapiens_hsa012001.12841787
49Cyanoamino acid metabolism_Homo sapiens_hsa004601.04603462
50Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.02221080
51Maturity onset diabetes of the young_Homo sapiens_hsa049501.01562679
52Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.97992894
53Arginine and proline metabolism_Homo sapiens_hsa003300.96554599
54Vitamin B6 metabolism_Homo sapiens_hsa007500.93669890
55Sulfur relay system_Homo sapiens_hsa041220.92514341
56Vitamin digestion and absorption_Homo sapiens_hsa049770.88022864
57Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.86916659
58Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.85027607
59Lysine degradation_Homo sapiens_hsa003100.82420467
60One carbon pool by folate_Homo sapiens_hsa006700.77526504
61Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.69863717
62Glycerolipid metabolism_Homo sapiens_hsa005610.68169202
63Glutathione metabolism_Homo sapiens_hsa004800.64835695
64Pentose phosphate pathway_Homo sapiens_hsa000300.56396799
65Fatty acid biosynthesis_Homo sapiens_hsa000610.53389540
66Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.48202548
67Metabolic pathways_Homo sapiens_hsa011000.45615863
68Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.39310416
69Pertussis_Homo sapiens_hsa051330.37298005
70Prion diseases_Homo sapiens_hsa050200.33520624
71alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.25340738
72Galactose metabolism_Homo sapiens_hsa000520.25096903
73Insulin resistance_Homo sapiens_hsa049310.22834122
74Fructose and mannose metabolism_Homo sapiens_hsa000510.22606989
75Linoleic acid metabolism_Homo sapiens_hsa005910.21194304
76Adipocytokine signaling pathway_Homo sapiens_hsa049200.21156892
77Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.20152354
78Glycerophospholipid metabolism_Homo sapiens_hsa005640.14204653
79Glucagon signaling pathway_Homo sapiens_hsa049220.08942626
80AMPK signaling pathway_Homo sapiens_hsa041520.01181456
81Protein digestion and absorption_Homo sapiens_hsa04974-0.2951416
82Amoebiasis_Homo sapiens_hsa05146-0.2455787
83Bladder cancer_Homo sapiens_hsa05219-0.2450131
84Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.2414920
85Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.2334235
86Sphingolipid metabolism_Homo sapiens_hsa00600-0.2299859
87Vascular smooth muscle contraction_Homo sapiens_hsa04270-0.2183250
88Type II diabetes mellitus_Homo sapiens_hsa04930-0.2160578
89Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.2156819
90Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1953959
91Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.1944355
92Circadian rhythm_Homo sapiens_hsa04710-0.1936462
93Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1877054
94Hepatitis C_Homo sapiens_hsa05160-0.1774952
95Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1699844
96Renin-angiotensin system_Homo sapiens_hsa04614-0.1697585
97Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1588942
98Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1548518
99Regulation of autophagy_Homo sapiens_hsa04140-0.1502895
100Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1468479
101African trypanosomiasis_Homo sapiens_hsa05143-0.1463723
102Insulin signaling pathway_Homo sapiens_hsa04910-0.1053335
103Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0876104
104Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.0847612
105Other glycan degradation_Homo sapiens_hsa00511-0.0744423
106Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0680530
107Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0435568
108Mineral absorption_Homo sapiens_hsa04978-0.0272726
109Serotonergic synapse_Homo sapiens_hsa04726-0.0139362

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