AFG3L1P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)8.37664996
2nucleobase catabolic process (GO:0046113)6.65472565
3postsynaptic membrane organization (GO:0001941)5.14204700
4neurotransmitter catabolic process (GO:0042135)4.88239870
5response to dietary excess (GO:0002021)4.88092038
6protein localization to synapse (GO:0035418)4.38730135
7auditory behavior (GO:0031223)4.15946183
8response to misfolded protein (GO:0051788)4.12775033
9forebrain neuron differentiation (GO:0021879)3.99466719
10regulation of short-term neuronal synaptic plasticity (GO:0048172)3.98547936
11synaptic vesicle maturation (GO:0016188)3.91309489
12mechanosensory behavior (GO:0007638)3.89267903
13negative regulation of telomere maintenance (GO:0032205)3.79762847
14synapse assembly (GO:0007416)3.70568018
15ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043163.58045656
16positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc3.57801035
17regulation of hydrogen peroxide metabolic process (GO:0010310)3.57498738
18adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.53190781
19type B pancreatic cell proliferation (GO:0044342)3.46652107
20positive regulation of synapse assembly (GO:0051965)3.45200486
21activated T cell proliferation (GO:0050798)3.41799122
22positive regulation of protein homooligomerization (GO:0032464)3.40045937
23regulation of microtubule-based movement (GO:0060632)3.38539366
24sensory perception of smell (GO:0007608)3.37123521
25synaptic transmission, cholinergic (GO:0007271)3.35916503
26neuron cell-cell adhesion (GO:0007158)3.31283659
27behavioral response to nicotine (GO:0035095)3.27109252
28dopamine receptor signaling pathway (GO:0007212)3.20713716
29G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.17409656
30synapsis (GO:0007129)3.16928757
31neuron recognition (GO:0008038)3.16369993
32regulation of telomere maintenance (GO:0032204)3.15391627
33aspartate family amino acid catabolic process (GO:0009068)3.07984075
34regulation of protein homooligomerization (GO:0032462)3.05926475
35protein localization to vacuole (GO:0072665)3.00411390
36protein localization to lysosome (GO:0061462)3.00411390
37axon regeneration (GO:0031103)2.98696538
38establishment of mitochondrion localization (GO:0051654)2.97570402
39layer formation in cerebral cortex (GO:0021819)2.96614341
40negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.94367134
41positive regulation of cellular response to oxidative stress (GO:1900409)2.91755973
42positive regulation of response to oxidative stress (GO:1902884)2.91755973
43axonal fasciculation (GO:0007413)2.91338374
44spinal cord development (GO:0021510)2.90567159
45meiotic chromosome segregation (GO:0045132)2.87930710
46axon cargo transport (GO:0008088)2.87429577
47cellular ketone body metabolic process (GO:0046950)2.84298698
48presynaptic membrane assembly (GO:0097105)2.82861723
49positive regulation of TOR signaling (GO:0032008)2.82786653
50establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.81055447
51mitochondrion transport along microtubule (GO:0047497)2.81055447
52regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.80940290
53regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.80673890
54anterograde axon cargo transport (GO:0008089)2.78633536
55sequestering of actin monomers (GO:0042989)2.75153375
56embryonic camera-type eye development (GO:0031076)2.73657092
57type B pancreatic cell development (GO:0003323)2.71997221
58piRNA metabolic process (GO:0034587)2.71102987
59positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.70922275
60positive regulation of filopodium assembly (GO:0051491)2.70303565
61male meiosis I (GO:0007141)2.69097496
62lysine catabolic process (GO:0006554)2.68870820
63lysine metabolic process (GO:0006553)2.68870820
64regulation of nuclear cell cycle DNA replication (GO:0033262)2.64915500
65reciprocal DNA recombination (GO:0035825)2.64227235
66reciprocal meiotic recombination (GO:0007131)2.64227235
67transmission of nerve impulse (GO:0019226)2.64201671
68growth hormone secretion (GO:0030252)2.61310219
69glycerophospholipid catabolic process (GO:0046475)2.61187568
70cell migration in hindbrain (GO:0021535)2.59596433
71cellular response to electrical stimulus (GO:0071257)2.56888250
72nervous system development (GO:0007399)2.56515435
73regulation of filopodium assembly (GO:0051489)2.56438601
74synapse organization (GO:0050808)2.55661034
75central nervous system projection neuron axonogenesis (GO:0021952)2.53492176
76presynaptic membrane organization (GO:0097090)2.53449439
77response to auditory stimulus (GO:0010996)2.53434690
78adult feeding behavior (GO:0008343)2.49612193
79respiratory system process (GO:0003016)2.48439495
80DNA methylation involved in gamete generation (GO:0043046)2.48233955
81glutamate receptor signaling pathway (GO:0007215)2.48085862
82cardiac right ventricle morphogenesis (GO:0003215)2.46259093
83neurofilament cytoskeleton organization (GO:0060052)2.44183745
84positive regulation of dendritic spine development (GO:0060999)2.42992244
85detection of chemical stimulus involved in sensory perception of smell (GO:0050911)2.42751556
86hippocampus development (GO:0021766)2.41077564
87calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.39641774
88ketone body metabolic process (GO:1902224)2.38132823
89brain morphogenesis (GO:0048854)2.36421591
90urogenital system development (GO:0001655)2.36322244
91macroautophagy (GO:0016236)2.36190791
92histone H3 deacetylation (GO:0070932)2.31657645
93skeletal muscle organ development (GO:0060538)2.31343070
94negative regulation of protein oligomerization (GO:0032460)2.29889976
95amyloid precursor protein metabolic process (GO:0042982)2.29510361
96DNA strand renaturation (GO:0000733)2.28931364
97chromosome organization involved in meiosis (GO:0070192)2.27745037
98sensory perception of chemical stimulus (GO:0007606)2.27581141
99regulation of synapse assembly (GO:0051963)2.27271570
100neurotransmitter-gated ion channel clustering (GO:0072578)2.27070609

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1NR4A2_19515692_ChIP-ChIP_MN9D_Mouse5.66920411
2RBPJ_22232070_ChIP-Seq_NCS_Mouse4.31866292
3CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons3.81944540
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.61090446
5IGF1R_20145208_ChIP-Seq_DFB_Human3.21493060
6ZNF274_21170338_ChIP-Seq_K562_Hela3.10295819
7TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.51462324
8NOTCH1_21737748_ChIP-Seq_TLL_Human2.50721771
9REST_21632747_ChIP-Seq_MESCs_Mouse2.38166508
10REST_18959480_ChIP-ChIP_MESCs_Mouse2.26729945
11ESR1_15608294_ChIP-ChIP_MCF-7_Human2.25170779
12HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.20560987
13ELF1_20517297_ChIP-Seq_JURKAT_Human2.14069243
14SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.13955443
15CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.04205443
16ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.99439185
17EZH2_22144423_ChIP-Seq_EOC_Human1.99355497
18RNF2_27304074_Chip-Seq_NSC_Mouse1.97313145
19JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.90131731
20MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.82509900
21GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.81014201
22YY1_21170310_ChIP-Seq_MESCs_Mouse1.74672497
23EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.71974743
24VDR_22108803_ChIP-Seq_LS180_Human1.71520302
25IRF1_19129219_ChIP-ChIP_H3396_Human1.67822523
26GABP_19822575_ChIP-Seq_HepG2_Human1.65998067
27RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.61109824
28ETS1_20019798_ChIP-Seq_JURKAT_Human1.60102925
29EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.59001010
30SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.57232111
31KDM5A_27292631_Chip-Seq_BREAST_Human1.53558020
32CIITA_25753668_ChIP-Seq_RAJI_Human1.47763715
33TP53_22573176_ChIP-Seq_HFKS_Human1.46021851
34PHF8_20622854_ChIP-Seq_HELA_Human1.45467039
35HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.43368431
36ERA_21632823_ChIP-Seq_H3396_Human1.42387733
37CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.40096903
38CBX2_27304074_Chip-Seq_ESCs_Mouse1.35739783
39XRN2_22483619_ChIP-Seq_HELA_Human1.33836190
40EZH2_27294783_Chip-Seq_ESCs_Mouse1.32892229
41ETS1_21867929_ChIP-Seq_TH2_Mouse1.31972715
42DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.30942286
43SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.30594496
44TP53_22127205_ChIP-Seq_IMR90_Human1.29682478
45POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.28788484
46TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28788484
47DCP1A_22483619_ChIP-Seq_HELA_Human1.28757621
48EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.28168682
49KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.25417914
50GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.25196028
51EWS_26573619_Chip-Seq_HEK293_Human1.24969166
52ELK4_26923725_Chip-Seq_MESODERM_Mouse1.23490378
53TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.18648824
54GABP_17652178_ChIP-ChIP_JURKAT_Human1.18621744
55EST1_17652178_ChIP-ChIP_JURKAT_Human1.17113588
56MYC_18940864_ChIP-ChIP_HL60_Human1.16587346
57CTCF_27219007_Chip-Seq_Bcells_Human1.14109252
58VDR_23849224_ChIP-Seq_CD4+_Human1.13597649
59E2F1_17053090_ChIP-ChIP_MCF-7_Human1.13544971
60P68_20966046_ChIP-Seq_HELA_Human1.12779746
61FOXP1_21924763_ChIP-Seq_HESCs_Human1.12676677
62RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.10719741
63OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.08160911
64RARB_27405468_Chip-Seq_BRAIN_Mouse1.07339670
65PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.06941287
66EZH2_27304074_Chip-Seq_ESCs_Mouse1.06867007
67NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.06080040
68FOXM1_23109430_ChIP-Seq_U2OS_Human1.04784714
69BMI1_23680149_ChIP-Seq_NPCS_Mouse1.04236597
70SOX3_22085726_ChIP-Seq_NPCs_Mouse1.03173494
71GATA1_26923725_Chip-Seq_HPCs_Mouse1.03099897
72CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02430610
73CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.01299108
74ZFP281_18757296_ChIP-ChIP_E14_Mouse1.01088351
75HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.00524611
76SMC4_20622854_ChIP-Seq_HELA_Human1.00137837
77DNAJC2_21179169_ChIP-ChIP_NT2_Human0.99273629
78MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.98265774
79YY1_22570637_ChIP-Seq_MALME-3M_Human0.98193332
80RUNX1_26923725_Chip-Seq_HPCs_Mouse0.97720937
81OCT4_20526341_ChIP-Seq_ESCs_Human0.97717854
82TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.97498974
83SUZ12_27294783_Chip-Seq_ESCs_Mouse0.97202515
84VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.94962751
85NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.94957776
86GATA3_21878914_ChIP-Seq_MCF-7_Human0.94610391
87RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.94247638
88CTBP1_25329375_ChIP-Seq_LNCAP_Human0.94217123
89E2F1_20622854_ChIP-Seq_HELA_Human0.93758877
90GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91579403
91SALL1_21062744_ChIP-ChIP_HESCs_Human0.90964365
92ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.90801906
93JARID2_20075857_ChIP-Seq_MESCs_Mouse0.90509345
94CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.89750968
95FOXP3_21729870_ChIP-Seq_TREG_Human0.89544396
96BCL6_27268052_Chip-Seq_Bcells_Human0.89396292
97CTCF_20526341_ChIP-Seq_ESCs_Human0.87572372
98CTCF_18555785_ChIP-Seq_MESCs_Mouse0.87501803
99THAP11_20581084_ChIP-Seq_MESCs_Mouse0.86782235
100RNF2_27304074_Chip-Seq_ESCs_Mouse0.86502581

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003122_maternal_imprinting5.53663024
2MP0006276_abnormal_autonomic_nervous3.96870129
3MP0003121_genomic_imprinting3.21725215
4MP0005645_abnormal_hypothalamus_physiol3.02165416
5MP0001502_abnormal_circadian_rhythm2.93529960
6MP0001529_abnormal_vocalization2.85976380
7MP0000778_abnormal_nervous_system2.57525611
8MP0005423_abnormal_somatic_nervous2.47971960
9MP0004859_abnormal_synaptic_plasticity2.39714945
10MP0003787_abnormal_imprinting2.07135279
11MP0003329_amyloid_beta_deposits1.95245110
12MP0003635_abnormal_synaptic_transmissio1.89447633
13MP0002653_abnormal_ependyma_morphology1.88305202
14MP0001984_abnormal_olfaction1.88150422
15MP0004885_abnormal_endolymph1.85119515
16MP0004924_abnormal_behavior1.82096393
17MP0005386_behavior/neurological_phenoty1.82096393
18MP0000566_synostosis1.81027808
19MP0003880_abnormal_central_pattern1.79469088
20MP0008877_abnormal_DNA_methylation1.76195907
21MP0002557_abnormal_social/conspecific_i1.74788610
22MP0002063_abnormal_learning/memory/cond1.72062062
23MP0002822_catalepsy1.71805446
24MP0004142_abnormal_muscle_tone1.70208467
25MP0002064_seizures1.67063526
26MP0002102_abnormal_ear_morphology1.66714220
27MP0002876_abnormal_thyroid_physiology1.62962944
28MP0008995_early_reproductive_senescence1.62702098
29MP0009745_abnormal_behavioral_response1.59460000
30MP0009046_muscle_twitch1.55912732
31MP0003011_delayed_dark_adaptation1.54403801
32MP0002733_abnormal_thermal_nociception1.51711131
33MP0008872_abnormal_physiological_respon1.51229386
34MP0004811_abnormal_neuron_physiology1.48643698
35MP0002735_abnormal_chemical_nociception1.48617789
36MP0000569_abnormal_digit_pigmentation1.47847512
37MP0002572_abnormal_emotion/affect_behav1.47674581
38MP0003136_yellow_coat_color1.46774160
39MP0000631_abnormal_neuroendocrine_gland1.43413068
40MP0006292_abnormal_olfactory_placode1.34661759
41MP0001968_abnormal_touch/_nociception1.33520490
42MP0010094_abnormal_chromosome_stability1.30042756
43MP0002067_abnormal_sensory_capabilities1.29123504
44MP0008770_decreased_survivor_rate1.27007174
45MP0003123_paternal_imprinting1.26794337
46MP0008058_abnormal_DNA_repair1.25953618
47MP0001905_abnormal_dopamine_level1.25241096
48MP0002882_abnormal_neuron_morphology1.23992820
49MP0001970_abnormal_pain_threshold1.23252594
50MP0001486_abnormal_startle_reflex1.18097639
51MP0002152_abnormal_brain_morphology1.17999844
52MP0000955_abnormal_spinal_cord1.15423322
53MP0002210_abnormal_sex_determination1.15065473
54MP0004742_abnormal_vestibular_system1.14328205
55MP0001440_abnormal_grooming_behavior1.13917598
56MP0009840_abnormal_foam_cell1.11895062
57MP0000015_abnormal_ear_pigmentation1.10345713
58MP0003693_abnormal_embryo_hatching1.07957090
59MP0005174_abnormal_tail_pigmentation1.06109432
60MP0002736_abnormal_nociception_after1.03421989
61MP0002184_abnormal_innervation1.03256103
62MP0003698_abnormal_male_reproductive1.02626658
63MP0003879_abnormal_hair_cell0.97749583
64MP0002752_abnormal_somatic_nervous0.96480319
65MP0003861_abnormal_nervous_system0.94547610
66MP0005253_abnormal_eye_physiology0.93141505
67MP0001986_abnormal_taste_sensitivity0.92273925
68MP0001929_abnormal_gametogenesis0.92224245
69MP0008961_abnormal_basal_metabolism0.89778799
70MP0002272_abnormal_nervous_system0.89723264
71MP0001501_abnormal_sleep_pattern0.89261684
72MP0002066_abnormal_motor_capabilities/c0.88717499
73MP0005551_abnormal_eye_electrophysiolog0.86967542
74MP0004133_heterotaxia0.86829178
75MP0000747_muscle_weakness0.84731325
76MP0001348_abnormal_lacrimal_gland0.83651899
77MP0002069_abnormal_eating/drinking_beha0.83486331
78MP0002909_abnormal_adrenal_gland0.83029601
79MP0005195_abnormal_posterior_eye0.82765633
80MP0005266_abnormal_metabolism0.81993548
81MP0003646_muscle_fatigue0.80653183
82MP0003786_premature_aging0.80235420
83MP0000427_abnormal_hair_cycle0.79301036
84MP0003111_abnormal_nucleus_morphology0.79239438
85MP0000647_abnormal_sebaceous_gland0.77771991
86MP0002082_postnatal_lethality0.76947552
87MP0010770_preweaning_lethality0.76947552
88MP0001145_abnormal_male_reproductive0.75772033
89MP0002229_neurodegeneration0.75552121
90MP0000604_amyloidosis0.75532534
91MP0010768_mortality/aging0.74518667
92MP0010769_abnormal_survival0.74279456
93MP0004270_analgesia0.73753993
94MP0004858_abnormal_nervous_system0.72172067
95MP0003172_abnormal_lysosome_physiology0.70928991
96MP0002970_abnormal_white_adipose0.68598280
97MP0002095_abnormal_skin_pigmentation0.67627703
98MP0000026_abnormal_inner_ear0.67479682
99MP0005452_abnormal_adipose_tissue0.67466501
100MP0000653_abnormal_sex_gland0.66480686

Predicted human phenotypes

RankGene SetZ-score
1Type II lissencephaly (HP:0007260)5.48781818
2Cerebellar dysplasia (HP:0007033)5.09295086
3Hypoplasia of the pons (HP:0012110)4.89849871
4Abnormality of the pons (HP:0007361)4.58088885
5Lissencephaly (HP:0001339)3.90007296
6Aplasia/Hypoplasia of the brainstem (HP:0007362)3.67736683
7Hypoplasia of the brainstem (HP:0002365)3.67736683
8Polyphagia (HP:0002591)3.57685491
9Calf muscle hypertrophy (HP:0008981)3.50484888
10Severe muscular hypotonia (HP:0006829)3.17696832
11Pancreatic cysts (HP:0001737)3.07390337
12Muscle hypertrophy of the lower extremities (HP:0008968)2.95571914
13Pachygyria (HP:0001302)2.94714133
14Hypoventilation (HP:0002791)2.87366909
15Patellar aplasia (HP:0006443)2.79070911
16Large eyes (HP:0001090)2.76335125
17Abnormality of the labia minora (HP:0012880)2.75722103
18Shoulder girdle muscle weakness (HP:0003547)2.67925549
19Elfin facies (HP:0004428)2.55202918
20Oligodactyly (hands) (HP:0001180)2.53994414
21Abnormality of midbrain morphology (HP:0002418)2.52451634
22Molar tooth sign on MRI (HP:0002419)2.52451634
23Aplasia/Hypoplasia of the patella (HP:0006498)2.50083765
24Myokymia (HP:0002411)2.49423213
25Abnormality of DNA repair (HP:0003254)2.45420495
26Hyperthyroidism (HP:0000836)2.44631329
27Pelvic girdle muscle weakness (HP:0003749)2.43819243
28Pancreatic fibrosis (HP:0100732)2.41824604
29Hyperacusis (HP:0010780)2.40010590
30Retinal dysplasia (HP:0007973)2.37296660
31Frequent falls (HP:0002359)2.36168007
32Abnormality of the hip-girdle musculature (HP:0001445)2.31706887
33Abnormality of the musculature of the pelvis (HP:0001469)2.31706887
34Abnormal hair whorl (HP:0010721)2.28879281
35True hermaphroditism (HP:0010459)2.27588105
36Overriding aorta (HP:0002623)2.26793153
37Nephronophthisis (HP:0000090)2.24246059
38Hyperventilation (HP:0002883)2.15429671
39Broad-based gait (HP:0002136)2.08562927
40Poor head control (HP:0002421)2.07219014
41Protruding tongue (HP:0010808)2.05767606
42Birth length less than 3rd percentile (HP:0003561)2.05361189
43Rib fusion (HP:0000902)2.04940173
44Cerebellar hypoplasia (HP:0001321)2.04477463
45Abnormal number of erythroid precursors (HP:0012131)2.04426944
46Renovascular hypertension (HP:0100817)2.01645900
47Attenuation of retinal blood vessels (HP:0007843)2.00797698
48Limb-girdle muscle atrophy (HP:0003797)2.00768099
49Abnormality of the carotid arteries (HP:0005344)1.98775587
50Insomnia (HP:0100785)1.98120884
51Pendular nystagmus (HP:0012043)1.96957302
52Chromosomal breakage induced by crosslinking agents (HP:0003221)1.96142098
53Limb dystonia (HP:0002451)1.95113271
54Abnormality of the renal medulla (HP:0100957)1.94352983
55Gait imbalance (HP:0002141)1.94178522
56Hypoplastic iliac wings (HP:0002866)1.93894566
57Abnormal biliary tract physiology (HP:0012439)1.91841854
58Bile duct proliferation (HP:0001408)1.91841854
59Intellectual disability, profound (HP:0002187)1.91514515
60Flat cornea (HP:0007720)1.90224834
61Failure to thrive in infancy (HP:0001531)1.89988333
62Abnormality of the ileum (HP:0001549)1.89984308
63Hypsarrhythmia (HP:0002521)1.88625603
64Hip dysplasia (HP:0001385)1.88340218
65Dandy-Walker malformation (HP:0001305)1.88063144
66Hemiplegia (HP:0002301)1.87599032
67Death in childhood (HP:0003819)1.85961580
68Abnormal eating behavior (HP:0100738)1.85753290
69Holoprosencephaly (HP:0001360)1.84895644
70Meckel diverticulum (HP:0002245)1.84686823
71Epileptic encephalopathy (HP:0200134)1.83062992
72Agitation (HP:0000713)1.78949185
73EEG with generalized epileptiform discharges (HP:0011198)1.78310833
74Aplasia/Hypoplasia of the uvula (HP:0010293)1.78004968
75Achilles tendon contracture (HP:0001771)1.76768743
76Abnormality of the vitreous humor (HP:0004327)1.76731092
77Difficulty climbing stairs (HP:0003551)1.75369153
78Esotropia (HP:0000565)1.74886927
79Anencephaly (HP:0002323)1.74849898
80Abnormality of the diencephalon (HP:0010662)1.73236230
81Progressive microcephaly (HP:0000253)1.73131055
82Morphological abnormality of the pyramidal tract (HP:0002062)1.71526214
83Drooling (HP:0002307)1.71419003
8411 pairs of ribs (HP:0000878)1.71027568
85Congenital stationary night blindness (HP:0007642)1.70525059
86Epileptiform EEG discharges (HP:0011182)1.69667529
87Generalized myoclonic seizures (HP:0002123)1.69565355
88Spastic tetraparesis (HP:0001285)1.69407141
89Non-midline cleft lip (HP:0100335)1.69206434
90Preaxial hand polydactyly (HP:0001177)1.68275730
91Cystic liver disease (HP:0006706)1.67859466
92Sclerocornea (HP:0000647)1.66950212
93Absent speech (HP:0001344)1.64054642
94Status epilepticus (HP:0002133)1.63862162
95Chromsome breakage (HP:0040012)1.63596907
96Optic nerve coloboma (HP:0000588)1.62536541
97Duplicated collecting system (HP:0000081)1.62082939
98Oligodactyly (HP:0012165)1.58981504
99Severe visual impairment (HP:0001141)1.58970479
100Hypoplasia of the corpus callosum (HP:0002079)1.58732621

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK14.17575172
2CASK3.51859291
3TYRO33.01316935
4DYRK22.92482814
5BMPR1B2.82868114
6EPHA32.79766065
7MAP4K22.78464152
8WNK42.44442897
9FRK2.42826948
10NTRK22.26381713
11ZAK2.20718116
12MAP3K42.11804870
13SIK22.04748057
14PHKG21.92528838
15PHKG11.92528838
16TLK11.75579620
17MAP2K71.72400525
18PINK11.61875607
19MAPK131.50579211
20CSNK1G21.50326653
21UHMK11.42946566
22ADRBK21.35012374
23PRKD31.34630358
24CSNK1G31.34055888
25CHEK21.27510588
26FES1.24782596
27CSNK1A1L1.20586121
28DYRK1A1.14220057
29MAP2K61.12554226
30LATS21.10860578
31DYRK31.08915276
32NTRK31.07283721
33MKNK21.03767865
34TNIK1.02862061
35NEK21.02159484
36ACVR1B1.01875828
37LMTK21.01287522
38ATR0.99784078
39CDC70.99239556
40ALK0.98690693
41WNK30.96675572
42DYRK1B0.95428509
43CSNK1G10.87592286
44MAPK150.86786789
45PAK30.85003795
46OXSR10.83125357
47PKN10.82527501
48PLK20.81797435
49MAPK120.81500492
50MARK20.80411387
51RPS6KA50.79525908
52PRKAA10.77547057
53STK390.75882362
54CDK120.73729789
55HIPK20.70287292
56MAP2K40.69710965
57PRKCQ0.69214301
58DAPK20.69011296
59CSNK1D0.67710671
60BRD40.65901598
61PDK20.65108944
62AURKA0.63119332
63EPHB10.62791223
64JAK30.61994978
65PRKCG0.58827777
66PLK10.58756643
67CDK50.57953378
68PRKCI0.57305546
69ATM0.55534630
70NUAK10.55384609
71BCR0.54757917
72PRKDC0.53008803
73GSK3B0.48111842
74STK110.47617485
75CSNK1A10.45778124
76INSRR0.45659107
77MAP3K70.45179912
78MAPK140.45162822
79FGFR40.45081279
80CDK10.44805201
81CSNK1E0.42467632
82CDK20.42201231
83NLK0.40532409
84NME10.40503123
85MAPK110.40183684
86MAPK80.39241931
87PTK60.39157867
88MARK30.38990922
89PRKCH0.36960895
90PRKCZ0.36752202
91ADRBK10.35068350
92CHEK10.34975094
93MAPK90.34343089
94TNK20.33514468
95NEK60.32797384
96CHUK0.32600973
97PAK60.32458256
98WNK10.30888144
99TGFBR10.30764058
100RPS6KA60.29631597

Predicted pathways (KEGG)

RankGene SetZ-score
1Fanconi anemia pathway_Homo sapiens_hsa034603.17777864
2Homologous recombination_Homo sapiens_hsa034402.93796600
3alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.73055451
4Olfactory transduction_Homo sapiens_hsa047402.61402933
5Selenocompound metabolism_Homo sapiens_hsa004502.46489611
6Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.40074211
7Phototransduction_Homo sapiens_hsa047442.28168272
8RNA polymerase_Homo sapiens_hsa030202.19416308
9Dopaminergic synapse_Homo sapiens_hsa047282.04203077
10Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.03904670
11Linoleic acid metabolism_Homo sapiens_hsa005911.97685192
12Synaptic vesicle cycle_Homo sapiens_hsa047211.93041243
13Notch signaling pathway_Homo sapiens_hsa043301.90259312
14Collecting duct acid secretion_Homo sapiens_hsa049661.88230089
15Nicotine addiction_Homo sapiens_hsa050331.88058525
16Glutamatergic synapse_Homo sapiens_hsa047241.87378863
17Morphine addiction_Homo sapiens_hsa050321.81013118
18Ether lipid metabolism_Homo sapiens_hsa005651.74061627
19p53 signaling pathway_Homo sapiens_hsa041151.73143570
20Butanoate metabolism_Homo sapiens_hsa006501.61524592
21Circadian entrainment_Homo sapiens_hsa047131.61361057
22GABAergic synapse_Homo sapiens_hsa047271.54918695
23Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.51083849
24Basal transcription factors_Homo sapiens_hsa030221.51043232
25Alcoholism_Homo sapiens_hsa050341.50108468
26Nitrogen metabolism_Homo sapiens_hsa009101.45335874
27Cholinergic synapse_Homo sapiens_hsa047251.42478565
28Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.40343813
29ABC transporters_Homo sapiens_hsa020101.38253227
30Axon guidance_Homo sapiens_hsa043601.35721835
31Insulin secretion_Homo sapiens_hsa049111.34705478
32Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.34322670
33Dorso-ventral axis formation_Homo sapiens_hsa043201.29159374
34Lysine degradation_Homo sapiens_hsa003101.22857483
35Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.22606004
36Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.21275168
37mRNA surveillance pathway_Homo sapiens_hsa030151.20692857
38Tryptophan metabolism_Homo sapiens_hsa003801.20628504
39Regulation of autophagy_Homo sapiens_hsa041401.20467418
40Cocaine addiction_Homo sapiens_hsa050301.19792836
41Lysosome_Homo sapiens_hsa041421.19031549
42Parkinsons disease_Homo sapiens_hsa050121.14096294
43Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.12897719
44Oxidative phosphorylation_Homo sapiens_hsa001901.12690124
45Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.11572810
46Glycerophospholipid metabolism_Homo sapiens_hsa005641.08510430
47Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.06842432
48Sulfur relay system_Homo sapiens_hsa041220.99938887
49Oocyte meiosis_Homo sapiens_hsa041140.91386857
50Huntingtons disease_Homo sapiens_hsa050160.86668587
51Cardiac muscle contraction_Homo sapiens_hsa042600.85232402
52Circadian rhythm_Homo sapiens_hsa047100.83728105
53Hippo signaling pathway_Homo sapiens_hsa043900.83093624
54Serotonergic synapse_Homo sapiens_hsa047260.82890582
55Oxytocin signaling pathway_Homo sapiens_hsa049210.82463599
56Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.81654054
57Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.78779834
58Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.75764424
59Cell cycle_Homo sapiens_hsa041100.74882045
60Carbohydrate digestion and absorption_Homo sapiens_hsa049730.73352338
61RNA degradation_Homo sapiens_hsa030180.73268783
62Steroid biosynthesis_Homo sapiens_hsa001000.73133967
63Amphetamine addiction_Homo sapiens_hsa050310.69221268
64Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.67500360
65Base excision repair_Homo sapiens_hsa034100.66893522
66Alzheimers disease_Homo sapiens_hsa050100.66517518
67Spliceosome_Homo sapiens_hsa030400.66089028
68RNA transport_Homo sapiens_hsa030130.65029506
69Maturity onset diabetes of the young_Homo sapiens_hsa049500.63905109
70Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.61311846
71Cyanoamino acid metabolism_Homo sapiens_hsa004600.59580885
72Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.56935410
73Hedgehog signaling pathway_Homo sapiens_hsa043400.54504480
74Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.54042679
75T cell receptor signaling pathway_Homo sapiens_hsa046600.53860331
76Long-term depression_Homo sapiens_hsa047300.53154199
77Sphingolipid metabolism_Homo sapiens_hsa006000.52588003
78Taste transduction_Homo sapiens_hsa047420.51566896
79Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.50343706
80AMPK signaling pathway_Homo sapiens_hsa041520.48734288
81FoxO signaling pathway_Homo sapiens_hsa040680.47088058
82Gastric acid secretion_Homo sapiens_hsa049710.47059274
83Sphingolipid signaling pathway_Homo sapiens_hsa040710.46691991
84MAPK signaling pathway_Homo sapiens_hsa040100.45631905
85Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.45475981
86Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.44014628
87Vibrio cholerae infection_Homo sapiens_hsa051100.43003116
88Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.41805719
89Apoptosis_Homo sapiens_hsa042100.40809940
90Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.39774504
91VEGF signaling pathway_Homo sapiens_hsa043700.39377122
92Glucagon signaling pathway_Homo sapiens_hsa049220.33643904
93Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.32385279
94Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.31944565
95Systemic lupus erythematosus_Homo sapiens_hsa053220.31672927
96Nucleotide excision repair_Homo sapiens_hsa034200.31471812
97cAMP signaling pathway_Homo sapiens_hsa040240.30829457
98Ovarian steroidogenesis_Homo sapiens_hsa049130.30206990
99Ras signaling pathway_Homo sapiens_hsa040140.29589282
100Non-homologous end-joining_Homo sapiens_hsa034500.27513039

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