ADRB3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the family of beta adrenergic receptors, which mediate catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor is located mainly in the adipose tissue and is involved in the regulation of lipolysis and thermogenesis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of sequestering of triglyceride (GO:0010889)8.46244298
2triglyceride catabolic process (GO:0019433)8.23101006
3white fat cell differentiation (GO:0050872)7.93600117
4biotin metabolic process (GO:0006768)7.92210717
5valine metabolic process (GO:0006573)7.64855776
6neutral lipid catabolic process (GO:0046461)7.34585182
7acylglycerol catabolic process (GO:0046464)7.34585182
8* brown fat cell differentiation (GO:0050873)7.01527862
9fatty acid transmembrane transport (GO:1902001)6.65296451
10tachykinin receptor signaling pathway (GO:0007217)6.51050079
11triglyceride biosynthetic process (GO:0019432)6.17801403
12carnitine shuttle (GO:0006853)6.15188395
13acylglycerol biosynthetic process (GO:0046463)5.89647834
14neutral lipid biosynthetic process (GO:0046460)5.89647834
15regulation of cholesterol storage (GO:0010885)5.82202081
16lipid particle organization (GO:0034389)5.81351363
17positive regulation of fatty acid oxidation (GO:0046321)5.80213609
18positive regulation of fatty acid beta-oxidation (GO:0032000)5.78684287
19negative regulation of macrophage derived foam cell differentiation (GO:0010745)5.61014610
20glycerolipid catabolic process (GO:0046503)5.42567910
21lipid storage (GO:0019915)5.33772811
22fatty acid beta-oxidation (GO:0006635)5.32944915
23branched-chain amino acid metabolic process (GO:0009081)5.15572190
24branched-chain amino acid catabolic process (GO:0009083)5.06089486
25behavioral response to nicotine (GO:0035095)5.05618021
26fatty-acyl-CoA biosynthetic process (GO:0046949)5.03161544
27acyl-CoA biosynthetic process (GO:0071616)4.90092772
28thioester biosynthetic process (GO:0035384)4.90092772
29carnitine transmembrane transport (GO:1902603)4.87305174
30fatty acid homeostasis (GO:0055089)4.84162448
31response to dietary excess (GO:0002021)4.83026111
32fatty-acyl-CoA metabolic process (GO:0035337)4.78987156
33long-chain fatty-acyl-CoA metabolic process (GO:0035336)4.78422432
34coenzyme A biosynthetic process (GO:0015937)4.78073776
35long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)4.76843880
36triglyceride metabolic process (GO:0006641)4.72203008
37fatty acid oxidation (GO:0019395)4.69008137
38acetyl-CoA metabolic process (GO:0006084)4.66109682
39lipid oxidation (GO:0034440)4.62529634
40fatty acid catabolic process (GO:0009062)4.48729025
41amino-acid betaine transport (GO:0015838)4.43910715
42carnitine transport (GO:0015879)4.43910715
43acylglycerol metabolic process (GO:0006639)4.41768554
44plasma lipoprotein particle clearance (GO:0034381)4.41093197
45regulation of fatty acid oxidation (GO:0046320)4.38036927
46neutral lipid metabolic process (GO:0006638)4.35079617
47negative regulation of protein autophosphorylation (GO:0031953)4.32135159
48complement activation, alternative pathway (GO:0006957)4.26575682
49negative regulation of lipid storage (GO:0010888)4.25589872
50positive regulation of lipid catabolic process (GO:0050996)4.23225704
51positive regulation of fatty acid metabolic process (GO:0045923)4.21924465
52regulation of fatty acid beta-oxidation (GO:0031998)4.18212663
53negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)4.17023614
54negative regulation of granulocyte differentiation (GO:0030853)4.15510614
55protein heterotrimerization (GO:0070208)4.14907808
56tryptophan catabolic process (GO:0006569)4.14814859
57indole-containing compound catabolic process (GO:0042436)4.14814859
58indolalkylamine catabolic process (GO:0046218)4.14814859
59alpha-linolenic acid metabolic process (GO:0036109)4.14033818
60positive regulation of digestive system process (GO:0060456)4.11275772
61negative regulation of phagocytosis (GO:0050765)4.05991127
62pentose-phosphate shunt (GO:0006098)4.04746695
63regulation of macrophage derived foam cell differentiation (GO:0010743)4.01057262
64response to pheromone (GO:0019236)3.99890899
65detection of light stimulus involved in sensory perception (GO:0050962)3.99719910
66detection of light stimulus involved in visual perception (GO:0050908)3.99719910
67NADPH regeneration (GO:0006740)3.97079169
68kynurenine metabolic process (GO:0070189)3.94819706
69indolalkylamine metabolic process (GO:0006586)3.93631173
70intracellular lipid transport (GO:0032365)3.90534583
71detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.90386667
72cellular response to lithium ion (GO:0071285)3.90342595
73ovulation from ovarian follicle (GO:0001542)3.89547137
74platelet dense granule organization (GO:0060155)3.87930261
75tricarboxylic acid metabolic process (GO:0072350)3.85158986
76regulation of cAMP-dependent protein kinase activity (GO:2000479)3.84827636
77CDP-diacylglycerol biosynthetic process (GO:0016024)3.83029108
78positive regulation of lipid storage (GO:0010884)3.81090317
79positive regulation of cholesterol efflux (GO:0010875)3.76540259
80negative regulation of DNA biosynthetic process (GO:2000279)3.74704150
81coenzyme A metabolic process (GO:0015936)3.71037428
82negative regulation of macrophage differentiation (GO:0045650)3.68151757
83positive regulation of sterol transport (GO:0032373)3.67848782
84positive regulation of cholesterol transport (GO:0032376)3.67848782
85tryptophan metabolic process (GO:0006568)3.66753111
86regulation of triglyceride catabolic process (GO:0010896)3.66458707
87fucose catabolic process (GO:0019317)3.65879862
88L-fucose metabolic process (GO:0042354)3.65879862
89L-fucose catabolic process (GO:0042355)3.65879862
90oxaloacetate metabolic process (GO:0006107)3.65649686
91positive regulation of glucose import (GO:0046326)3.64375447
92neural tube formation (GO:0001841)3.63686861
93positive regulation of glomerulus development (GO:0090193)3.61317797
94cornea development in camera-type eye (GO:0061303)3.60945360
95DNA deamination (GO:0045006)3.59915151
96glycerol metabolic process (GO:0006071)3.59580555
97regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)3.56829499
98negative regulation of gluconeogenesis (GO:0045721)3.51955127
99sulfur amino acid catabolic process (GO:0000098)3.51489025
100regulation of lipid storage (GO:0010883)3.46992196
101positive regulation of cellular response to insulin stimulus (GO:1900078)3.46897876
102regulation of glycogen (starch) synthase activity (GO:2000465)3.45359959
103growth hormone receptor signaling pathway (GO:0060396)3.42519769
104monocarboxylic acid catabolic process (GO:0072329)3.41971061
105regulation of triglyceride biosynthetic process (GO:0010866)3.39347552
106regulation of triglyceride metabolic process (GO:0090207)3.39150422
107cochlea development (GO:0090102)3.39009785
108diacylglycerol metabolic process (GO:0046339)3.38548602
109negative regulation of metanephros development (GO:0072217)3.37474001
110quaternary ammonium group transport (GO:0015697)3.37142871
111long-chain fatty acid transport (GO:0015909)3.37074024
112regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.35479201
1132-oxoglutarate metabolic process (GO:0006103)3.35176863
114CDP-diacylglycerol metabolic process (GO:0046341)3.35127418
115fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.34533374
116regulation of macrophage chemotaxis (GO:0010758)3.33663449
117triglyceride homeostasis (GO:0070328)3.30505972
118acylglycerol homeostasis (GO:0055090)3.30505972
119protein K11-linked deubiquitination (GO:0035871)3.30177658
120adenosine metabolic process (GO:0046085)3.27948623
121L-serine transport (GO:0015825)3.27741641
122axoneme assembly (GO:0035082)3.25090319
123cellular lipid catabolic process (GO:0044242)3.23533655
124respiratory chain complex IV assembly (GO:0008535)3.21984150
125behavioral response to ethanol (GO:0048149)3.21486924
126retinal cone cell development (GO:0046549)3.19969734
127protein-cofactor linkage (GO:0018065)3.19338263
128positive regulation of oligodendrocyte differentiation (GO:0048714)3.17798436
129amine catabolic process (GO:0009310)3.00647974
130cellular biogenic amine catabolic process (GO:0042402)3.00647974
131piRNA metabolic process (GO:0034587)2.98013097
132auditory receptor cell stereocilium organization (GO:0060088)2.95758212
133indole-containing compound metabolic process (GO:0042430)2.94834002
134DNA double-strand break processing (GO:0000729)2.93402385
135postsynaptic membrane organization (GO:0001941)2.91852436
136cytochrome complex assembly (GO:0017004)2.91330696
137preassembly of GPI anchor in ER membrane (GO:0016254)2.87872782
138replication fork processing (GO:0031297)2.86067027
139multicellular organism reproduction (GO:0032504)2.85513571
140inner ear receptor cell development (GO:0060119)2.84553167
141embryonic epithelial tube formation (GO:0001838)2.84189075
142reflex (GO:0060004)2.80596962
143sulfation (GO:0051923)2.80483641
144protein complex biogenesis (GO:0070271)2.78149296
145mannosylation (GO:0097502)2.77180703
146inner ear receptor stereocilium organization (GO:0060122)2.76362220
147regulation of rhodopsin mediated signaling pathway (GO:0022400)2.73630564
148GPI anchor metabolic process (GO:0006505)2.73495728
149epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.71608108
150cilium morphogenesis (GO:0060271)2.70947966
151L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.70448301
152NAD biosynthetic process (GO:0009435)2.70088630
153amino acid salvage (GO:0043102)2.69698614
154L-methionine salvage (GO:0071267)2.69698614
155L-methionine biosynthetic process (GO:0071265)2.69698614
156limb bud formation (GO:0060174)2.69194325
157sphingoid metabolic process (GO:0046519)2.66519497
158mitochondrial respiratory chain complex I assembly (GO:0032981)2.65630373
159NADH dehydrogenase complex assembly (GO:0010257)2.65630373
160mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.65630373
161water-soluble vitamin biosynthetic process (GO:0042364)2.65234082
162rhodopsin mediated signaling pathway (GO:0016056)2.64968851
163peptidyl-histidine modification (GO:0018202)2.64613274
164photoreceptor cell maintenance (GO:0045494)2.64528392
165gamma-aminobutyric acid transport (GO:0015812)2.64510963
166RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.64231969
167regulation of meiosis I (GO:0060631)2.61423271
168S-adenosylmethionine metabolic process (GO:0046500)2.60529315
169epithelial tube formation (GO:0072175)2.59674524
170organic cation transport (GO:0015695)2.59158547
171G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.58776663
172benzene-containing compound metabolic process (GO:0042537)2.58686341
173photoreceptor cell development (GO:0042461)2.57759622
174protein polyglutamylation (GO:0018095)2.57508031
175glycosphingolipid biosynthetic process (GO:0006688)2.56238029
176regulation of hippo signaling (GO:0035330)2.56005385
177primary amino compound metabolic process (GO:1901160)2.55066010
178C4-dicarboxylate transport (GO:0015740)2.53480650
179righting reflex (GO:0060013)2.53169108
180recombinational repair (GO:0000725)2.52958532
181sympathetic nervous system development (GO:0048485)2.51246020
182double-strand break repair via homologous recombination (GO:0000724)2.51109255
183mitochondrial respiratory chain complex assembly (GO:0033108)2.47982888
184regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033392.47532299
185negative regulation of cell cycle arrest (GO:0071157)2.45527307
186aromatic amino acid family catabolic process (GO:0009074)2.45460673
187detection of chemical stimulus involved in sensory perception of smell (GO:0050911)2.45145417
188detection of mechanical stimulus involved in sensory perception (GO:0050974)2.44637639
189regulation of neurotransmitter uptake (GO:0051580)2.44520693
190negative regulation of mast cell activation (GO:0033004)2.44479770
191negative regulation of cytosolic calcium ion concentration (GO:0051481)2.44464130
192phasic smooth muscle contraction (GO:0014821)2.43922660
193negative regulation of transcription regulatory region DNA binding (GO:2000678)2.43902914
194somite development (GO:0061053)2.42862105
195epithelial cilium movement (GO:0003351)2.41387513
196RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.40111091
197tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.40111091
198visual perception (GO:0007601)2.39804508
199negative regulation of reactive oxygen species metabolic process (GO:2000378)2.39697954
200low-density lipoprotein particle clearance (GO:0034383)10.2075472

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse6.90783424
2CLOCK_20551151_ChIP-Seq_293T_Human4.51182630
3ZNF274_21170338_ChIP-Seq_K562_Hela3.55008137
4ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.45296308
5VDR_22108803_ChIP-Seq_LS180_Human3.39861372
6RXR_22158963_ChIP-Seq_LIVER_Mouse3.29690928
7GBX2_23144817_ChIP-Seq_PC3_Human3.19277016
8EZH2_22144423_ChIP-Seq_EOC_Human3.17863323
9LXR_22158963_ChIP-Seq_LIVER_Mouse2.92681724
10GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.91199868
11STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.82740311
12PPARA_22158963_ChIP-Seq_LIVER_Mouse2.81292290
13ZFP57_27257070_Chip-Seq_ESCs_Mouse2.76853672
14TP63_17297297_ChIP-ChIP_HaCaT_Human2.70066118
15E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.50669292
16FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.49813351
17* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse2.26460063
18GATA1_22025678_ChIP-Seq_K562_Human2.24453811
19CTBP2_25329375_ChIP-Seq_LNCAP_Human2.21973596
20NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.21480881
21POU3F2_20337985_ChIP-ChIP_501MEL_Human2.20115209
22P300_19829295_ChIP-Seq_ESCs_Human2.19828300
23IGF1R_20145208_ChIP-Seq_DFB_Human2.19593390
24PPARG_20887899_ChIP-Seq_3T3-L1_Mouse2.18975850
25CTBP1_25329375_ChIP-Seq_LNCAP_Human2.12784107
26EWS_26573619_Chip-Seq_HEK293_Human2.11594966
27FLI1_27457419_Chip-Seq_LIVER_Mouse2.07962272
28TRIM28_21343339_ChIP-Seq_HEK293_Human2.06375240
29ER_23166858_ChIP-Seq_MCF-7_Human2.03802467
30NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.03278663
31* PPARG_19300518_ChIP-PET_3T3-L1_Mouse15.4121607
32CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.91607465
33CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.90651366
34FUS_26573619_Chip-Seq_HEK293_Human1.89470804
35GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.85159682
36AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.80756892
37IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.79066345
38CBP_20019798_ChIP-Seq_JUKART_Human1.79066345
39RARG_19884340_ChIP-ChIP_MEFs_Mouse1.76662004
40PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.76241084
41PCGF2_27294783_Chip-Seq_ESCs_Mouse1.75833524
42BCAT_22108803_ChIP-Seq_LS180_Human1.73746653
43TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.73620802
44TAF15_26573619_Chip-Seq_HEK293_Human1.70491897
45UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.68708072
46SALL1_21062744_ChIP-ChIP_HESCs_Human1.66893118
47NOTCH1_21737748_ChIP-Seq_TLL_Human1.65973669
48CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.55507907
49SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.55462484
50STAT3_23295773_ChIP-Seq_U87_Human1.54428835
51SMAD4_21799915_ChIP-Seq_A2780_Human1.53418200
52POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.53214335
53SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.50626984
54HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.50100005
55HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.48951003
56STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.48793053
57TCF4_22108803_ChIP-Seq_LS180_Human1.48011056
58* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.47540483
59CBX2_27304074_Chip-Seq_ESCs_Mouse1.47537317
60EZH2_27294783_Chip-Seq_NPCs_Mouse1.47263028
61PIAS1_25552417_ChIP-Seq_VCAP_Human1.46834879
62PPAR_26484153_Chip-Seq_NCI-H1993_Human1.46411952
63TCF4_23295773_ChIP-Seq_U87_Human1.46309340
64IRF8_22096565_ChIP-ChIP_GC-B_Human1.45034801
65SUZ12_27294783_Chip-Seq_NPCs_Mouse1.44778051
66ZNF263_19887448_ChIP-Seq_K562_Human1.44682201
67AR_25329375_ChIP-Seq_VCAP_Human1.44529639
68PCGF2_27294783_Chip-Seq_NPCs_Mouse1.43896648
69SMAD3_21741376_ChIP-Seq_EPCs_Human1.43878784
70STAT3_1855785_ChIP-Seq_MESCs_Mouse1.43441268
71MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.42467144
72MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.40693531
73TP53_22573176_ChIP-Seq_HFKS_Human1.40194154
74SOX2_19829295_ChIP-Seq_ESCs_Human1.40085105
75NANOG_19829295_ChIP-Seq_ESCs_Human1.40085105
76NR3C1_21868756_ChIP-Seq_MCF10A_Human1.39696691
77EGR1_23403033_ChIP-Seq_LIVER_Mouse1.39477902
78CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.39176159
79E2F7_22180533_ChIP-Seq_HELA_Human1.38731812
80TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.38486441
81NFE2_27457419_Chip-Seq_LIVER_Mouse1.38432549
82KLF5_20875108_ChIP-Seq_MESCs_Mouse1.36441536
83GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.34299173
84TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.30762030
85CDX2_22108803_ChIP-Seq_LS180_Human1.30413247
86HIF1A_21447827_ChIP-Seq_MCF-7_Human1.30187894
87RUNX2_22187159_ChIP-Seq_PCA_Human1.29905756
88MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.29635040
89TOP2B_26459242_ChIP-Seq_MCF-7_Human1.27942923
90* EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.27541585
91SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.27381940
92NCOR_22424771_ChIP-Seq_293T_Human1.27356441
93IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.26445928
94TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25424147
95POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.25424147
96ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.25215060
97NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.24701833
98AR_21572438_ChIP-Seq_LNCaP_Human1.24563378
99SMAD4_21741376_ChIP-Seq_EPCs_Human1.24542296
100NANOG_18555785_Chip-Seq_ESCs_Mouse1.23753847
101PRDM14_20953172_ChIP-Seq_ESCs_Human1.23640708
102TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.23536995
103CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.22391214
104Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.21208944
105ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.20514126
106BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.20154236
107OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.19580651
108CRX_20693478_ChIP-Seq_RETINA_Mouse1.18716656
109EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.17450207
110IRF1_19129219_ChIP-ChIP_H3396_Human1.17383827
111GABP_17652178_ChIP-ChIP_JURKAT_Human1.16358551
112FLI1_21867929_ChIP-Seq_TH2_Mouse1.14705871
113BP1_19119308_ChIP-ChIP_Hs578T_Human1.13694855
114RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.13645111
115RNF2_27304074_Chip-Seq_NSC_Mouse1.12981851
116NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.12715932
117P53_22387025_ChIP-Seq_ESCs_Mouse1.12678006
118BMI1_23680149_ChIP-Seq_NPCS_Mouse1.12224539
119FOXA1_27270436_Chip-Seq_PROSTATE_Human1.11768498
120FOXA1_25329375_ChIP-Seq_VCAP_Human1.11768498
121FOXA1_21572438_ChIP-Seq_LNCaP_Human1.11342182
122NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.11176245
123BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.10569473
124PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.10131353
125SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.09112455
126KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.08499476
127KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.08499476
128KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.08499476
129OCT4_21477851_ChIP-Seq_ESCs_Mouse1.08211539
130CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.06878206
131E2F1_18555785_Chip-Seq_ESCs_Mouse1.05586514
132KDM2B_26808549_Chip-Seq_REH_Human1.03119056
133AUTS2_25519132_ChIP-Seq_293T-REX_Human1.02173267
134TBL1_22424771_ChIP-Seq_293T_Human1.01795596
135NFYB_21822215_ChIP-Seq_K562_Human1.00964543
136TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.00742405
137KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.00623866
138TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.00244034
139STAT3_18555785_Chip-Seq_ESCs_Mouse0.99799812
140HOXB7_26014856_ChIP-Seq_BT474_Human0.99299626
141PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.99088735
142ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.99061779
143PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.98336362
144* SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.98187410
145FOXO3_23340844_ChIP-Seq_DLD1_Human0.97698147
146IRF8_21731497_ChIP-ChIP_J774_Mouse0.96026154
147KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.93186344
148* TCF3_18692474_ChIP-Seq_MEFs_Mouse0.92423043
149TBX20_22080862_ChIP-Seq_HEART_Mouse0.92373827
150TBX20_22328084_ChIP-Seq_HEART_Mouse0.92373827
151VDR_24787735_ChIP-Seq_THP-1_Human0.91125602
152GATA2_21666600_ChIP-Seq_HMVEC_Human0.91087914
153CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.89395052
154ELK4_26923725_Chip-Seq_MESODERM_Mouse0.87552684
155* SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.87230264
156CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.87086812
157* TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.85242355
158CJUN_26792858_Chip-Seq_BT549_Human0.84118104
159RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.82986774
160PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.81283021
161SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.80274458
162NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.78232580
163NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.77783591
164ESR2_21235772_ChIP-Seq_MCF-7_Human0.76100866
165P63_26484246_Chip-Seq_KERATINOCYTES_Human0.75817541
166ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.75743047
167SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.73837047
168SOX9_24532713_ChIP-Seq_HFSC_Mouse0.72373456
169MYB_21317192_ChIP-Seq_ERMYB_Mouse0.71124450
170* SALL4_18804426_ChIP-ChIP_XEN_Mouse0.70267589
171ESR1_21235772_ChIP-Seq_MCF-7_Human0.69306726
172SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.67908359
173GATA3_24758297_ChIP-Seq_MCF-7_Human0.67579315
174GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.66684810
175P300_27058665_Chip-Seq_ZR-75-30cells_Human0.66341791
176NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.63873998
177CDX2_20551321_ChIP-Seq_CACO-2_Human0.62841407
178CTNNB1_20460455_ChIP-Seq_HCT116_Human0.62430962
179* TCF3_18692474_ChIP-Seq_MESCs_Mouse0.60381090
180HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.60045577
181NANOG_18555785_ChIP-Seq_MESCs_Mouse0.59973770
182PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.59427472
183PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.58081797
184CSB_26484114_Chip-Seq_FIBROBLAST_Human0.56277116
185FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.54643329
186RXR_22108803_ChIP-Seq_LS180_Human0.54571401
187FOXA2_19822575_ChIP-Seq_HepG2_Human0.54532000
188ELK3_25401928_ChIP-Seq_HUVEC_Human0.53947005
189RACK7_27058665_Chip-Seq_MCF-7_Human0.53900432
190KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.53230628
191SOX2_27498859_Chip-Seq_STOMACH_Mouse0.53212204
192* NANOG_18692474_ChIP-Seq_MEFs_Mouse0.52621790
193* SOX2_18692474_ChIP-Seq_MEFs_Mouse0.52585157
194CEBPB_22108803_ChIP-Seq_LS180_Human0.52449556
195SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.52368449
196* P300_27268052_Chip-Seq_Bcells_Human0.52025522
197* HNF4A_19822575_ChIP-Seq_HepG2_Human0.51876366

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005670_abnormal_white_adipose8.88557071
2MP0005666_abnormal_adipose_tissue5.66652499
3MP0004185_abnormal_adipocyte_glucose4.77427914
4MP0004130_abnormal_muscle_cell4.76439604
5MP0005375_adipose_tissue_phenotype3.96599730
6MP0008438_abnormal_cutaneous_collagen3.87397448
7MP0002971_abnormal_brown_adipose3.32477343
8MP0003195_calcinosis3.25298233
9MP0002876_abnormal_thyroid_physiology3.19516191
10MP0009115_abnormal_fat_cell3.00615001
11MP0002837_dystrophic_cardiac_calcinosis2.95501551
12MP0002102_abnormal_ear_morphology2.93923094
13MP0010329_abnormal_lipoprotein_level2.93563694
14MP0001968_abnormal_touch/_nociception2.82676900
15MP0005551_abnormal_eye_electrophysiolog2.77958118
16MP0002736_abnormal_nociception_after2.77853910
17MP0000013_abnormal_adipose_tissue2.72166045
18MP0000372_irregular_coat_pigmentation2.62706725
19MP0003191_abnormal_cellular_cholesterol2.61871618
20MP0005275_abnormal_skin_tensile2.56528783
21MP0005646_abnormal_pituitary_gland2.47078418
22* MP0005334_abnormal_fat_pad2.43583114
23MP0000003_abnormal_adipose_tissue2.41898123
24MP0008877_abnormal_DNA_methylation2.38171811
25MP0002970_abnormal_white_adipose2.37598937
26MP0003136_yellow_coat_color2.29933250
27MP0002118_abnormal_lipid_homeostasis2.10459301
28MP0001661_extended_life_span2.08503634
29MP0004885_abnormal_endolymph2.06039257
30MP0003186_abnormal_redox_activity1.99686227
31MP0005253_abnormal_eye_physiology1.97264421
32MP0005535_abnormal_body_temperature1.95422666
33MP0004043_abnormal_pH_regulation1.94384913
34MP0003705_abnormal_hypodermis_morpholog1.89698194
35MP0003880_abnormal_central_pattern1.87802202
36MP0001485_abnormal_pinna_reflex1.84043629
37MP0006072_abnormal_retinal_apoptosis1.82709967
38* MP0008872_abnormal_physiological_respon1.78512815
39MP0003959_abnormal_lean_body1.75822866
40MP0005377_hearing/vestibular/ear_phenot1.73419866
41MP0003878_abnormal_ear_physiology1.73419866
42MP0001486_abnormal_startle_reflex1.73335632
43MP0005365_abnormal_bile_salt1.71752275
44MP0009745_abnormal_behavioral_response1.71337685
45MP0003724_increased_susceptibility_to1.70417259
46MP0009697_abnormal_copulation1.63762849
47MP0004272_abnormal_basement_membrane1.63327092
48MP0004142_abnormal_muscle_tone1.62153927
49MP0000569_abnormal_digit_pigmentation1.61437770
50MP0003806_abnormal_nucleotide_metabolis1.60369377
51MP0005448_abnormal_energy_balance1.58334555
52MP0000427_abnormal_hair_cycle1.56287336
53MP0008875_abnormal_xenobiotic_pharmacok1.51852737
54MP0002938_white_spotting1.50859550
55MP0002234_abnormal_pharynx_morphology1.49542814
56MP0002751_abnormal_autonomic_nervous1.48486865
57MP0003690_abnormal_glial_cell1.48307278
58MP0000609_abnormal_liver_physiology1.47631832
59MP0002735_abnormal_chemical_nociception1.46239530
60MP0001986_abnormal_taste_sensitivity1.45686574
61MP0004742_abnormal_vestibular_system1.43508746
62MP0003828_pulmonary_edema1.39545353
63MP0001529_abnormal_vocalization1.37098140
64MP0010386_abnormal_urinary_bladder1.35556120
65* MP0005452_abnormal_adipose_tissue1.33967096
66MP0002254_reproductive_system_inflammat1.33656871
67MP0000631_abnormal_neuroendocrine_gland1.31886801
68MP0001881_abnormal_mammary_gland1.31793274
69MP0005075_abnormal_melanosome_morpholog1.31526138
70MP0002138_abnormal_hepatobiliary_system1.29999397
71MP0006276_abnormal_autonomic_nervous1.28147995
72MP0006138_congestive_heart_failure1.26691286
73MP0002078_abnormal_glucose_homeostasis1.24882029
74MP0001984_abnormal_olfaction1.23808578
75MP0000343_altered_response_to1.23694356
76MP0002272_abnormal_nervous_system1.21225747
77MP0005174_abnormal_tail_pigmentation1.20830351
78MP0002095_abnormal_skin_pigmentation1.15968536
79MP0003787_abnormal_imprinting1.14702857
80MP0003566_abnormal_cell_adhesion1.14076384
81MP0005084_abnormal_gallbladder_morpholo1.12539298
82MP0002139_abnormal_hepatobiliary_system1.10620482
83MP0000026_abnormal_inner_ear1.08040411
84MP0001764_abnormal_homeostasis1.05717293
85MP0002796_impaired_skin_barrier1.04880300
86MP0002638_abnormal_pupillary_reflex1.04089548
87MP0008775_abnormal_heart_ventricle1.03783054
88MP0002163_abnormal_gland_morphology1.03300297
89MP0002332_abnormal_exercise_endurance1.02745864
90MP0006036_abnormal_mitochondrial_physio1.02599127
91MP0001963_abnormal_hearing_physiology1.02560915
92MP0003011_delayed_dark_adaptation1.01569757
93MP0004084_abnormal_cardiac_muscle1.00868440
94MP0005319_abnormal_enzyme/_coenzyme1.00826589
95MP0005171_absent_coat_pigmentation1.00637986
96MP0001727_abnormal_embryo_implantation0.98737115
97MP0002653_abnormal_ependyma_morphology0.98727492
98MP0002060_abnormal_skin_morphology0.98050434
99MP0005164_abnormal_response_to0.97155678
100MP0003718_maternal_effect0.96714138
101MP0003252_abnormal_bile_duct0.95142313
102MP0009046_muscle_twitch0.94474807
103MP0005584_abnormal_enzyme/coenzyme_acti0.93938975
104MP0001324_abnormal_eye_pigmentation0.92492593
105MP0004133_heterotaxia0.92350956
106MP0001501_abnormal_sleep_pattern0.91971688
107MP0000230_abnormal_systemic_arterial0.91111059
108MP0003646_muscle_fatigue0.90305722
109MP0002572_abnormal_emotion/affect_behav0.90004357
110MP0003950_abnormal_plasma_membrane0.88795102
111MP0001970_abnormal_pain_threshold0.88204380
112MP0000049_abnormal_middle_ear0.87827038
113MP0002733_abnormal_thermal_nociception0.87484640
114MP0000383_abnormal_hair_follicle0.87068742
115MP0003045_fibrosis0.87030839
116MP0002557_abnormal_social/conspecific_i0.86851767
117MP0002928_abnormal_bile_duct0.86807524
118MP0002166_altered_tumor_susceptibility0.85866441
119MP0003635_abnormal_synaptic_transmissio0.85798409
120MP0004145_abnormal_muscle_electrophysio0.85616816
121MP0000750_abnormal_muscle_regeneration0.85432833
122MP0002752_abnormal_somatic_nervous0.85208317
123MP0005385_cardiovascular_system_phenoty0.84904343
124MP0001544_abnormal_cardiovascular_syste0.84904343
125MP0002277_abnormal_respiratory_mucosa0.84549267
126MP0005195_abnormal_posterior_eye0.83876922
127MP0008995_early_reproductive_senescence0.82404812
128MP0002184_abnormal_innervation0.82171700
129MP0002067_abnormal_sensory_capabilities0.82064446
130MP0005410_abnormal_fertilization0.81369353
131MP0005360_urolithiasis0.81225271
132MP0003786_premature_aging0.80012478
133MP0000647_abnormal_sebaceous_gland0.79546902
134MP0003698_abnormal_male_reproductive0.78819800
135MP0005367_renal/urinary_system_phenotyp0.77887805
136MP0000516_abnormal_urinary_system0.77887805
137MP0003943_abnormal_hepatobiliary_system0.77541364
138MP0008058_abnormal_DNA_repair0.76947134
139MP0004215_abnormal_myocardial_fiber0.76898378
140MP0005332_abnormal_amino_acid0.76529875
141MP0000538_abnormal_urinary_bladder0.76298265
142MP0002006_tumorigenesis0.76167146
143MP0000015_abnormal_ear_pigmentation0.75877969
144MP0004484_altered_response_of0.75874435
145MP0001853_heart_inflammation0.75000860
146MP0001756_abnormal_urination0.74982038
147MP0003953_abnormal_hormone_level0.74598222
148MP0005391_vision/eye_phenotype0.74386036
149MP0003948_abnormal_gas_homeostasis0.72647779
150MP0005620_abnormal_muscle_contractility0.71676193
151MP0003221_abnormal_cardiomyocyte_apopto0.71123788
152MP0009763_increased_sensitivity_to0.70244190
153MP0005647_abnormal_sex_gland0.69264153
154MP0004087_abnormal_muscle_fiber0.67512205
155MP0005645_abnormal_hypothalamus_physiol0.67020468
156MP0004782_abnormal_surfactant_physiolog0.66480292
157MP0005058_abnormal_lysosome_morphology0.65224415
158MP0003448_altered_tumor_morphology0.64349313
159MP0009643_abnormal_urine_homeostasis0.63382078
160MP0002168_other_aberrant_phenotype0.61813145
161MP0000858_altered_metastatic_potential0.61426813
162MP0005379_endocrine/exocrine_gland_phen0.57970366
163MP0009672_abnormal_birth_weight0.56814211
164MP0000759_abnormal_skeletal_muscle0.56542702
165MP0005076_abnormal_cell_differentiation0.55244224
166MP0000598_abnormal_liver_morphology0.55081510
167MP0002295_abnormal_pulmonary_circulatio0.54798654
168MP0004147_increased_porphyrin_level0.54089846
169MP0000249_abnormal_blood_vessel0.52933941
170MP0009780_abnormal_chondrocyte_physiolo0.52792914
171MP0001545_abnormal_hematopoietic_system0.51647008
172MP0005397_hematopoietic_system_phenotyp0.51647008
173MP0002909_abnormal_adrenal_gland0.51463162
174MP0005376_homeostasis/metabolism_phenot0.51167498
175MP0001533_abnormal_skeleton_physiology0.50311509
176MP0005330_cardiomyopathy0.50015605
177MP0001177_atelectasis0.48603529
178MP0005167_abnormal_blood-brain_barrier0.48562750
179MP0005266_abnormal_metabolism0.48500304
180MP0002972_abnormal_cardiac_muscle0.47627154
181MP0008961_abnormal_basal_metabolism0.45455265
182MP0000627_abnormal_mammary_gland0.43421477
183MP0001879_abnormal_lymphatic_vessel0.43049770
184MP0010630_abnormal_cardiac_muscle0.43044350
185MP0000751_myopathy0.42465598

Predicted human phenotypes

RankGene SetZ-score
1Oligomenorrhea (HP:0000876)9.38133711
2Acanthosis nigricans (HP:0000956)7.67949927
3Hyperglycinuria (HP:0003108)7.05826209
4Hypertriglyceridemia (HP:0002155)6.98650603
5Abnormality of serine family amino acid metabolism (HP:0010894)5.52078873
6Abnormality of glycine metabolism (HP:0010895)5.52078873
7Complement deficiency (HP:0004431)5.35956945
8Insulin-resistant diabetes mellitus (HP:0000831)4.93748884
9Long foot (HP:0001833)4.92955105
10Pancreatic cysts (HP:0001737)4.12008211
11Hydroxyprolinuria (HP:0003080)4.08029305
12Abnormality of proline metabolism (HP:0010907)4.08029305
13Myoglobinuria (HP:0002913)3.98116816
14Pigmentary retinal degeneration (HP:0001146)3.95278416
15Abnormality of complement system (HP:0005339)3.95039879
16Pancreatic fibrosis (HP:0100732)3.86548566
17True hermaphroditism (HP:0010459)3.83883475
18Growth hormone excess (HP:0000845)3.83236618
19Multiple enchondromatosis (HP:0005701)3.82496942
20Insulin resistance (HP:0000855)3.81784041
21Abnormality of fatty-acid metabolism (HP:0004359)3.75795012
22Hyperglycinemia (HP:0002154)3.68775495
23Difficulty running (HP:0009046)3.67821577
24Attenuation of retinal blood vessels (HP:0007843)3.67659351
25Hypoglycemic coma (HP:0001325)3.56141776
26Reduced subcutaneous adipose tissue (HP:0003758)3.55992337
27Hemorrhage of the eye (HP:0011885)3.49592694
28Congenital stationary night blindness (HP:0007642)3.49590475
29Hypoalphalipoproteinemia (HP:0003233)3.46433063
30Increased muscle lipid content (HP:0009058)3.42024034
31Bone cyst (HP:0012062)3.41983026
32Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.41239728
33Abnormality of macular pigmentation (HP:0008002)3.40619625
34Thyroid-stimulating hormone excess (HP:0002925)3.38581490
35Rhabdomyolysis (HP:0003201)3.32463983
36Epidermoid cyst (HP:0200040)3.31157102
37Systemic lupus erythematosus (HP:0002725)3.27182025
38Subcapsular cataract (HP:0000523)3.23796513
39Hyperammonemia (HP:0001987)3.22563581
40Molar tooth sign on MRI (HP:0002419)3.19166423
41Abnormality of midbrain morphology (HP:0002418)3.19166423
42Autoimmune thrombocytopenia (HP:0001973)3.18191095
43Chronic hepatic failure (HP:0100626)3.12000872
44Ketosis (HP:0001946)3.10130296
45Nausea (HP:0002018)3.09389084
46Ketoacidosis (HP:0001993)3.08878140
47Pendular nystagmus (HP:0012043)3.06128918
48Constricted visual fields (HP:0001133)3.03811847
49Large hands (HP:0001176)3.02977192
50Myocardial infarction (HP:0001658)3.01014493
51Decreased electroretinogram (ERG) amplitude (HP:0000654)2.99393386
52Hyperpituitarism (HP:0010514)2.93773612
53Abnormality of dicarboxylic acid metabolism (HP:0010995)2.93658566
54Dicarboxylic aciduria (HP:0003215)2.93658566
55Increased connective tissue (HP:0009025)2.93144554
56Abnormality of the renal cortex (HP:0011035)2.92874897
57Chorioretinal atrophy (HP:0000533)2.91663378
58Inability to walk (HP:0002540)2.89859164
59Decreased central vision (HP:0007663)2.89001215
60Increased corneal curvature (HP:0100692)2.88776099
61Keratoconus (HP:0000563)2.88776099
62Abolished electroretinogram (ERG) (HP:0000550)2.88710219
63Nephronophthisis (HP:0000090)2.86837314
64Progressive inability to walk (HP:0002505)2.85227795
65Hyperthyroidism (HP:0000836)2.83202836
66Congenital sensorineural hearing impairment (HP:0008527)2.83023885
67Abnormal cartilage morphology (HP:0002763)2.81327947
68Type II lissencephaly (HP:0007260)2.81298689
69Gaze-evoked nystagmus (HP:0000640)2.78918195
70Pancreatitis (HP:0001733)2.78235461
71Tetraparesis (HP:0002273)2.75329412
72Aplasia/Hypoplasia of the fovea (HP:0008060)2.74101566
73Hypoplasia of the fovea (HP:0007750)2.74101566
74Prenatal maternal abnormality (HP:0002686)2.68250134
75Facial diplegia (HP:0001349)2.66329380
76Absent speech (HP:0001344)2.64838532
77Abnormality of the renal medulla (HP:0100957)2.63208283
78Hyperventilation (HP:0002883)2.63161182
79Cystic liver disease (HP:0006706)2.60605881
80Limb hypertonia (HP:0002509)2.60394903
81Abnormal rod and cone electroretinograms (HP:0008323)2.58410698
82Abnormal hemoglobin (HP:0011902)2.57026947
83Accelerated skeletal maturation (HP:0005616)2.55500130
84Medial flaring of the eyebrow (HP:0010747)2.46870999
85Hyperlipoproteinemia (HP:0010980)2.45153810
86Skin nodule (HP:0200036)2.44353648
87Xanthomatosis (HP:0000991)2.41174215
88Abnormality of the fovea (HP:0000493)2.40822912
89Anencephaly (HP:0002323)2.40275771
90Chromsome breakage (HP:0040012)2.40232237
91Sclerocornea (HP:0000647)2.39364555
92Hypercholesterolemia (HP:0003124)2.36681446
93Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.36311974
94Prostate neoplasm (HP:0100787)2.35765689
95Lipoatrophy (HP:0100578)2.33258401
96Renal cortical cysts (HP:0000803)2.33045324
97Absent rod-and cone-mediated responses on ERG (HP:0007688)2.32165527
98Aplasia/Hypoplasia of the tongue (HP:0010295)2.31161893
99Neonatal hypoglycemia (HP:0001998)2.30742777
100Testicular atrophy (HP:0000029)2.27508353
101Clitoromegaly (HP:0000057)2.26561378
102Aplasia/Hypoplasia of the uvula (HP:0010293)2.23914958
103Tubular atrophy (HP:0000092)2.22086128
104Cerebral aneurysm (HP:0004944)2.21405542
105Hyperglycemia (HP:0003074)2.18889687
106Hypoproteinemia (HP:0003075)2.18866127
107Progressive cerebellar ataxia (HP:0002073)2.14926919
108Abnormality of glutamine family amino acid metabolism (HP:0010902)2.14889785
109Methylmalonic acidemia (HP:0002912)2.12814717
110Ankle contracture (HP:0006466)2.10986921
111Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.09587678
112Spinal rigidity (HP:0003306)2.08981141
113Bilateral microphthalmos (HP:0007633)2.08842370
114Toxemia of pregnancy (HP:0100603)2.07260313
115Prominent supraorbital ridges (HP:0000336)2.06721551
116Broad metatarsal (HP:0001783)2.06069835
117Aplasia/Hypoplasia of the spleen (HP:0010451)2.05471564
118Occipital encephalocele (HP:0002085)2.04741403
119Abnormality of the labia minora (HP:0012880)2.04628162
120Polygenic inheritance (HP:0010982)2.00208369
121Tubulointerstitial nephritis (HP:0001970)1.99936403
122Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.99855102
123Abnormality of alanine metabolism (HP:0010916)1.99855102
124Hyperalaninemia (HP:0003348)1.99855102
125Postaxial foot polydactyly (HP:0001830)1.99510083
126Abnormality of serum amino acid levels (HP:0003112)1.99454888
127Abnormal drinking behavior (HP:0030082)1.98096978
128Polydipsia (HP:0001959)1.98096978
129Small hand (HP:0200055)1.97804458
130Clumsiness (HP:0002312)1.97476477
131Male pseudohermaphroditism (HP:0000037)1.97438991
132Decreased subcutaneous fat (HP:0001002)1.95499682
133Hypothermia (HP:0002045)1.94947342
134Nephrogenic diabetes insipidus (HP:0009806)1.94116254
135Cerebellar dysplasia (HP:0007033)1.91553761
136Broad-based gait (HP:0002136)1.91251641
137Genital tract atresia (HP:0001827)1.90161250
138Polar cataract (HP:0010696)1.88928971
139Congenital hepatic fibrosis (HP:0002612)1.88519014
140Chromosomal breakage induced by crosslinking agents (HP:0003221)1.87974265
141Asplenia (HP:0001746)1.87843062
142Aplasia/Hypoplasia of the tibia (HP:0005772)1.87709634
143Acute encephalopathy (HP:0006846)1.87152163
144Macular degeneration (HP:0000608)1.86734481
145Oligohydramnios (HP:0001562)1.86701236
146Decreased circulating renin level (HP:0003351)1.86280068
147Optic disc pallor (HP:0000543)1.86180025
148Optic nerve hypoplasia (HP:0000609)1.85542156
149Acute necrotizing encephalopathy (HP:0006965)1.85183132
150Methylmalonic aciduria (HP:0012120)1.84577863
151Generalized aminoaciduria (HP:0002909)1.84400359
152Mitochondrial inheritance (HP:0001427)1.81638794
153Abnormality of subcutaneous fat tissue (HP:0001001)1.81505457
154Lethargy (HP:0001254)1.81334341
155Gait imbalance (HP:0002141)1.81223937
156Right ventricular cardiomyopathy (HP:0011663)1.80946466
157Focal seizures (HP:0007359)1.80115517
158Congenital, generalized hypertrichosis (HP:0004540)1.79660517
159Type I transferrin isoform profile (HP:0003642)1.79284378
160Thyroiditis (HP:0100646)1.79151642
161Lissencephaly (HP:0001339)1.79143357
162Polyuria (HP:0000103)1.78392708
163Vaginal atresia (HP:0000148)1.77789545
164Astigmatism (HP:0000483)1.77373754
165Brushfield spots (HP:0001088)1.77127895
166Turricephaly (HP:0000262)1.77064138
167Increased CSF lactate (HP:0002490)1.76971254
168Abnormal protein glycosylation (HP:0012346)1.76447292
169Abnormal glycosylation (HP:0012345)1.76447292
170Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.76447292
171Abnormal protein N-linked glycosylation (HP:0012347)1.76447292
172Hypolipoproteinemia (HP:0010981)1.76322866
173Congenital primary aphakia (HP:0007707)1.75686536
174Hepatocellular necrosis (HP:0001404)1.75418222
175Dynein arm defect of respiratory motile cilia (HP:0012255)1.75365870
176Absent/shortened dynein arms (HP:0200106)1.75365870
177Abnormality of the ileum (HP:0001549)1.75122729
178Rectal prolapse (HP:0002035)1.75061187
179Muscle fiber splitting (HP:0003555)1.74308108
180Progressive macrocephaly (HP:0004481)1.74129893
181Increased variability in muscle fiber diameter (HP:0003557)1.73393117
182Fair hair (HP:0002286)1.72480867
183IgG deficiency (HP:0004315)1.71441683
184Proximal amyotrophy (HP:0007126)1.71304890
185Cortical dysplasia (HP:0002539)1.68501216
186Fasciculations (HP:0002380)1.68089269
187Polyphagia (HP:0002591)1.65288789
188Hepatic necrosis (HP:0002605)1.65199113
189Type 1 muscle fiber predominance (HP:0003803)1.65179048
190Hepatosplenomegaly (HP:0001433)1.65110940
191Follicular hyperkeratosis (HP:0007502)1.64336284
192Abnormality of purine metabolism (HP:0004352)1.64120497
193Vomiting (HP:0002013)1.63245636
194Fibular hypoplasia (HP:0003038)1.61150523
195Gonadotropin excess (HP:0000837)1.59303385
196Muscle stiffness (HP:0003552)1.58875750

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CAMK1D7.47370809
2CAMK1G5.11939317
3SIK14.47003046
4TRIB34.44944479
5BCKDK4.32706949
6NUAK13.21548754
7PDK33.14358988
8PDK43.14358988
9MAP4K22.89464914
10ADRBK22.62055023
11LMTK22.45589519
12MST1R2.41149237
13PDK22.29409886
14CASK2.24898509
15RIPK12.23289272
16GRK12.22864628
17ACVR1B2.21348776
18BMPR1B2.08595971
19PRKAA22.07695106
20ERN12.06208392
21TRIM281.97733431
22MAPK131.86538178
23OXSR11.85638961
24ZAK1.81720169
25MST41.76766429
26TAOK31.76678706
27WNK31.72506861
28INSRR1.65707907
29STK391.61223121
30FGFR31.58221638
31CDK91.48555315
32VRK21.48436088
33BCR1.48153783
34CDK61.43604714
35IRAK31.39458935
36TLK11.38203989
37MAP3K61.36686997
38WNK41.34462307
39TGFBR21.30042854
40MAP3K41.24908883
41FRK1.24311150
42MET1.20783749
43MARK11.18829076
44DDR21.18282258
45PDGFRA1.14667642
46TAF11.09638921
47VRK11.09433836
48PLK21.09063416
49CSNK1A1L1.07529522
50TIE11.06919128
51ADRBK11.06727287
52EPHB21.06507931
53TXK1.05572083
54EIF2AK31.05392758
55PRKAA11.05207298
56TEC1.05099117
57LATS11.04729851
58FGFR21.03202079
59PLK41.02248695
60CSNK1G20.98044605
61LATS20.97965793
62EIF2AK20.96648959
63PINK10.96026821
64CDK120.94392446
65MKNK20.93861749
66PIK3CA0.93385326
67PAK30.93318137
68JAK10.93300251
69PRKCE0.92746235
70CSNK1G10.91825320
71NEK90.91508109
72MYLK0.90341599
73DYRK20.89799490
74MAP2K70.89187066
75NTRK30.87657677
76CDK40.85771202
77PRKD30.85301161
78MAP2K10.83974861
79MARK30.83505063
80MAPK110.82490092
81TNIK0.82487004
82OBSCN0.81896973
83ERBB30.80238064
84EPHA40.79515179
85NEK60.79128460
86CSNK1G30.78957564
87JAK20.77584827
88MAP3K120.75878693
89IRAK10.71768257
90MTOR0.70228972
91STK38L0.69637853
92PRKACG0.68208049
93JAK30.68162786
94NME10.67145607
95GSK3A0.66758541
96TGFBR10.66089365
97FGFR40.65981456
98WEE10.65570197
99IGF1R0.63597173
100BMX0.62788359
101FLT30.62162786
102MAPKAPK30.61194950
103PHKG20.60346001
104PHKG10.60346001
105PDPK10.59781137
106PRKCG0.58832457
107CSK0.58344922
108PKN10.56957872
109MUSK0.56890369
110KIT0.56702473
111PRKCQ0.55431419
112CSF1R0.54650714
113PLK30.53069418
114SGK20.52455493
115STK160.52111181
116MAPKAPK50.51991611
117ICK0.51915406
118CAMK10.51377693
119CSNK1A10.51213110
120AKT30.50727409
121PRKG20.49847702
122BRSK20.49497153
123PDK10.49221523
124PRKCH0.49040504
125FER0.48828484
126STK30.47307087
127IKBKB0.46285785
128CCNB10.45823271
129INSR0.45630907
130CAMK2A0.45225447
131CAMKK20.44070839
132ABL20.43093217
133PRKCI0.42319532
134PRKD20.41480084
135ITK0.40834120
136ATM0.40173725
137PDGFRB0.39907786
138DYRK30.38585485
139CSNK1D0.36991867
140TYK20.36976231
141MAPK150.36712318
142CDK30.36563267
143RPS6KB10.36023973
144TNK20.36013635
145PTK2B0.35928597
146STK110.35856948
147ILK0.35786522
148FGFR10.34798086
149PAK20.33115723
150AKT10.32627417
151MAPK120.31231647
152GRK50.31217219
153TRPM70.30574236
154PKN20.29023583
155MAP2K30.28986833
156PRKD10.28893891
157ABL10.24817426
158MAPK70.24601346
159SRC0.22726178
160MAPK30.22442126
161TTN0.18746801
162EPHA20.17270953
163AKT20.17121485
164TTK0.17088980
165TYRO30.15957047
166MAP3K140.15167261
167DAPK20.15108762
168ERBB40.14815329
169MAPK10.12063498
170RET0.11704220
171MAP2K40.11692881
172CDK70.11489206
173MAPK40.11200842

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000615.36348461
2Propanoate metabolism_Homo sapiens_hsa006404.74844752
3PPAR signaling pathway_Homo sapiens_hsa033204.45659898
4Valine, leucine and isoleucine degradation_Homo sapiens_hsa002803.78987359
5Fatty acid metabolism_Homo sapiens_hsa012123.71612235
6* Regulation of lipolysis in adipocytes_Homo sapiens_hsa049233.65665776
7Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.55469830
8Glycerolipid metabolism_Homo sapiens_hsa005613.13479197
9Fatty acid degradation_Homo sapiens_hsa000712.99676477
102-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.93380344
11Phototransduction_Homo sapiens_hsa047442.79349424
12Pyruvate metabolism_Homo sapiens_hsa006202.44003078
13Nicotine addiction_Homo sapiens_hsa050332.41865569
14Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.41146116
15beta-Alanine metabolism_Homo sapiens_hsa004102.24021935
16Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.03494273
17* Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.01138437
18Adipocytokine signaling pathway_Homo sapiens_hsa049201.98642750
19Carbon metabolism_Homo sapiens_hsa012001.96959993
20AMPK signaling pathway_Homo sapiens_hsa041521.94784622
21Caffeine metabolism_Homo sapiens_hsa002321.88271281
22Basal transcription factors_Homo sapiens_hsa030221.86057300
23One carbon pool by folate_Homo sapiens_hsa006701.84849522
24Fanconi anemia pathway_Homo sapiens_hsa034601.83201825
25Maturity onset diabetes of the young_Homo sapiens_hsa049501.78229421
26Olfactory transduction_Homo sapiens_hsa047401.77645654
27Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.75641446
28Peroxisome_Homo sapiens_hsa041461.74920590
29Steroid hormone biosynthesis_Homo sapiens_hsa001401.73657105
30Fat digestion and absorption_Homo sapiens_hsa049751.71956715
31Staphylococcus aureus infection_Homo sapiens_hsa051501.67709814
32Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.65781597
33Homologous recombination_Homo sapiens_hsa034401.65289050
34Morphine addiction_Homo sapiens_hsa050321.60531388
35Nitrogen metabolism_Homo sapiens_hsa009101.56845313
36Phenylalanine metabolism_Homo sapiens_hsa003601.49818025
37Protein export_Homo sapiens_hsa030601.48157432
38Selenocompound metabolism_Homo sapiens_hsa004501.47770085
39Ether lipid metabolism_Homo sapiens_hsa005651.44960661
40Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.44392370
41Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.43195143
42Vitamin B6 metabolism_Homo sapiens_hsa007501.41596044
43Tyrosine metabolism_Homo sapiens_hsa003501.32195239
44Primary immunodeficiency_Homo sapiens_hsa053401.29332237
45GABAergic synapse_Homo sapiens_hsa047271.27299844
46Taste transduction_Homo sapiens_hsa047421.24766132
47Fatty acid elongation_Homo sapiens_hsa000621.22729739
48Butanoate metabolism_Homo sapiens_hsa006501.22181167
49RNA degradation_Homo sapiens_hsa030181.21604706
50Oxidative phosphorylation_Homo sapiens_hsa001901.20763389
51Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.19015670
52Insulin resistance_Homo sapiens_hsa049311.17544102
53RNA polymerase_Homo sapiens_hsa030201.16497710
54Non-homologous end-joining_Homo sapiens_hsa034501.15968193
55Insulin signaling pathway_Homo sapiens_hsa049101.15186510
56Collecting duct acid secretion_Homo sapiens_hsa049661.13827808
57Pentose phosphate pathway_Homo sapiens_hsa000301.13333317
58Intestinal immune network for IgA production_Homo sapiens_hsa046721.12627286
59Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.12297516
60Tryptophan metabolism_Homo sapiens_hsa003801.11450966
61Proteasome_Homo sapiens_hsa030501.09905305
62Serotonergic synapse_Homo sapiens_hsa047261.04197231
63Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.96089228
64Mineral absorption_Homo sapiens_hsa049780.93561637
65Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.92780037
66Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.89991690
67Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.89783774
68Glucagon signaling pathway_Homo sapiens_hsa049220.86951164
69Complement and coagulation cascades_Homo sapiens_hsa046100.85827800
70Circadian entrainment_Homo sapiens_hsa047130.85825467
71Longevity regulating pathway - mammal_Homo sapiens_hsa042110.83670182
72Glycerophospholipid metabolism_Homo sapiens_hsa005640.82853705
73Glutamatergic synapse_Homo sapiens_hsa047240.82415793
74Cyanoamino acid metabolism_Homo sapiens_hsa004600.80632371
75Primary bile acid biosynthesis_Homo sapiens_hsa001200.80550512
76Biosynthesis of amino acids_Homo sapiens_hsa012300.78585930
77Arginine biosynthesis_Homo sapiens_hsa002200.76772342
78Regulation of autophagy_Homo sapiens_hsa041400.73882971
79Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.72777505
80Parkinsons disease_Homo sapiens_hsa050120.70663626
81Sphingolipid metabolism_Homo sapiens_hsa006000.70558181
82Fructose and mannose metabolism_Homo sapiens_hsa000510.70319443
83Autoimmune thyroid disease_Homo sapiens_hsa053200.70018971
84Insulin secretion_Homo sapiens_hsa049110.69265524
85alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.68341626
86Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.67979756
87Ovarian steroidogenesis_Homo sapiens_hsa049130.67517224
88Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.67201177
89* Salivary secretion_Homo sapiens_hsa049700.66696379
90Nucleotide excision repair_Homo sapiens_hsa034200.66419598
91* Calcium signaling pathway_Homo sapiens_hsa040200.66188431
92Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.65845948
93Purine metabolism_Homo sapiens_hsa002300.64014207
94Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.63594129
95ABC transporters_Homo sapiens_hsa020100.63230238
96Pentose and glucuronate interconversions_Homo sapiens_hsa000400.61329545
97Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.60330018
98Starch and sucrose metabolism_Homo sapiens_hsa005000.60041852
99Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.59658333
100Circadian rhythm_Homo sapiens_hsa047100.59277315
101Arachidonic acid metabolism_Homo sapiens_hsa005900.58106264
102Lysine degradation_Homo sapiens_hsa003100.56684958
103Asthma_Homo sapiens_hsa053100.55865284
104Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.54728342
105Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.53313402
106Central carbon metabolism in cancer_Homo sapiens_hsa052300.53195777
107Dopaminergic synapse_Homo sapiens_hsa047280.52846631
108Dorso-ventral axis formation_Homo sapiens_hsa043200.52215861
109Vascular smooth muscle contraction_Homo sapiens_hsa042700.51926596
110ECM-receptor interaction_Homo sapiens_hsa045120.46713591
111Cocaine addiction_Homo sapiens_hsa050300.45681972
112Type II diabetes mellitus_Homo sapiens_hsa049300.45434965
113Linoleic acid metabolism_Homo sapiens_hsa005910.45085026
114Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.44470496
115Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.44380114
116Rheumatoid arthritis_Homo sapiens_hsa053230.41567522
117Histidine metabolism_Homo sapiens_hsa003400.39266920
118SNARE interactions in vesicular transport_Homo sapiens_hsa041300.38810168
119Amphetamine addiction_Homo sapiens_hsa050310.38765232
120Chemical carcinogenesis_Homo sapiens_hsa052040.38147168
121Pyrimidine metabolism_Homo sapiens_hsa002400.35831305
122Protein digestion and absorption_Homo sapiens_hsa049740.35707865
123HIF-1 signaling pathway_Homo sapiens_hsa040660.34723584
124Huntingtons disease_Homo sapiens_hsa050160.33342806
125Hedgehog signaling pathway_Homo sapiens_hsa043400.33331340
126mTOR signaling pathway_Homo sapiens_hsa041500.32218868
127Acute myeloid leukemia_Homo sapiens_hsa052210.30541098
128Glutathione metabolism_Homo sapiens_hsa004800.30174263
129Metabolic pathways_Homo sapiens_hsa011000.27904078
130Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.26768393
131Drug metabolism - other enzymes_Homo sapiens_hsa009830.25183330
132Focal adhesion_Homo sapiens_hsa045100.20963113
133Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.20572556
134Galactose metabolism_Homo sapiens_hsa000520.19322524
135Thyroid cancer_Homo sapiens_hsa052160.18006497
136Retinol metabolism_Homo sapiens_hsa008300.16329151
137Prion diseases_Homo sapiens_hsa050200.15188591
138Lysosome_Homo sapiens_hsa041420.15172255
139Legionellosis_Homo sapiens_hsa051340.13928736
140Glycosaminoglycan degradation_Homo sapiens_hsa005310.13752100
141Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.13667208
142Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.12984885
143Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.11952541
144Adherens junction_Homo sapiens_hsa045200.09283061
145Small cell lung cancer_Homo sapiens_hsa052220.09106018
146PI3K-Akt signaling pathway_Homo sapiens_hsa041510.08474364
147Amoebiasis_Homo sapiens_hsa051460.07997455
148Jak-STAT signaling pathway_Homo sapiens_hsa046300.07988861
149Proteoglycans in cancer_Homo sapiens_hsa052050.06595378
150TGF-beta signaling pathway_Homo sapiens_hsa043500.05018900
151Renin-angiotensin system_Homo sapiens_hsa046140.04774091
152Cysteine and methionine metabolism_Homo sapiens_hsa002700.04769065
153Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.04432927
154Malaria_Homo sapiens_hsa051440.04410620
155Pertussis_Homo sapiens_hsa051330.04205339
156Sulfur relay system_Homo sapiens_hsa041220.02960659
157Viral myocarditis_Homo sapiens_hsa054160.02894051
158AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.02799832
159cAMP signaling pathway_Homo sapiens_hsa040240.02041274
160Toxoplasmosis_Homo sapiens_hsa051450.01844162
161Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.01029532
162Melanoma_Homo sapiens_hsa05218-0.0043753
163Sulfur metabolism_Homo sapiens_hsa00920-0.0040531

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