ADRB1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The adrenergic receptors (subtypes alpha 1, alpha 2, beta 1, and beta 2) are a prototypic family of guanine nucleotide binding regulatory protein-coupled receptors that mediate the physiological effects of the hormone epinephrine and the neurotransmitter norepinephrine. Specific polymorphisms in this gene have been shown to affect the resting heart rate and can be involved in heart failure. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1striated muscle hypertrophy (GO:0014897)4.69709023
2regulation of short-term neuronal synaptic plasticity (GO:0048172)4.60562451
3vocalization behavior (GO:0071625)4.51697877
4sulfation (GO:0051923)4.50198891
5otic vesicle formation (GO:0030916)4.43042270
6epithelial cell differentiation involved in kidney development (GO:0035850)4.38511745
7tryptophan metabolic process (GO:0006568)4.37090773
8regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.34342201
9pharyngeal system development (GO:0060037)4.31344664
10serotonin metabolic process (GO:0042428)4.27566526
11positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.23251223
12regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.22015565
13protein localization to synapse (GO:0035418)4.20731530
14muscle hypertrophy (GO:0014896)4.18980035
15regulation of phospholipid biosynthetic process (GO:0071071)4.18207577
16positive regulation of fatty acid oxidation (GO:0046321)4.10296749
17cell proliferation in forebrain (GO:0021846)4.10149797
18glutamate secretion (GO:0014047)4.07890431
19positive regulation of fatty acid beta-oxidation (GO:0032000)4.07721433
20regulation of glutamate receptor signaling pathway (GO:1900449)4.04715459
21synaptic vesicle exocytosis (GO:0016079)4.01861479
22membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.01506867
23cellular potassium ion homeostasis (GO:0030007)3.97656173
24neuron cell-cell adhesion (GO:0007158)3.91979744
25regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.86862655
26ionotropic glutamate receptor signaling pathway (GO:0035235)3.85136027
27regulation of cell proliferation involved in kidney development (GO:1901722)3.82625059
28regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.82076728
29locomotory exploration behavior (GO:0035641)3.81085064
30glutamate receptor signaling pathway (GO:0007215)3.79352575
31synaptic vesicle docking involved in exocytosis (GO:0016081)3.77185530
32regulation of glomerulus development (GO:0090192)3.70449677
33regulation of synaptic vesicle exocytosis (GO:2000300)3.70247400
34cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.68745484
35indolalkylamine metabolic process (GO:0006586)3.66232615
36positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.60867623
37presynaptic membrane assembly (GO:0097105)3.60696204
38positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.59982816
39kynurenine metabolic process (GO:0070189)3.55843792
40cerebellar Purkinje cell differentiation (GO:0021702)3.53776260
41primary amino compound metabolic process (GO:1901160)3.53245946
42neuronal action potential propagation (GO:0019227)3.52346625
43neurotransmitter-gated ion channel clustering (GO:0072578)3.46598867
44gamma-aminobutyric acid signaling pathway (GO:0007214)3.44018236
45synaptic vesicle maturation (GO:0016188)3.43365116
46regulation of synaptic vesicle transport (GO:1902803)3.42486455
47positive regulation of neurotransmitter secretion (GO:0001956)3.40268982
48regulation of long-term neuronal synaptic plasticity (GO:0048169)3.32485543
49striated muscle adaptation (GO:0014888)3.32427086
50cell communication by electrical coupling (GO:0010644)3.32412443
51neuron-neuron synaptic transmission (GO:0007270)3.29596263
52synaptic transmission, glutamatergic (GO:0035249)3.24568075
53negative regulation of synaptic transmission, GABAergic (GO:0032229)3.24321208
54indole-containing compound metabolic process (GO:0042430)3.23841913
55neuron recognition (GO:0008038)3.23216351
56behavioral response to nicotine (GO:0035095)3.23029087
57cochlea development (GO:0090102)3.22264694
58regulation of excitatory postsynaptic membrane potential (GO:0060079)3.21322586
59retinal cone cell development (GO:0046549)3.20880226
60response to histamine (GO:0034776)3.20733754
61G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.20659242
62purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.20626747
633-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.20626747
64regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.19750937
65forebrain neuron development (GO:0021884)3.17258928
66regulation of sequestering of triglyceride (GO:0010889)3.15954840
67regulation of neuronal synaptic plasticity (GO:0048168)3.15823761
68tryptophan catabolic process (GO:0006569)3.15355647
69indole-containing compound catabolic process (GO:0042436)3.15355647
70indolalkylamine catabolic process (GO:0046218)3.15355647
71G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.13692976
72regulation of voltage-gated calcium channel activity (GO:1901385)3.13485054
73regulation of hippo signaling (GO:0035330)3.13428589
74presynaptic membrane organization (GO:0097090)3.13140426
75mitochondrial respiratory chain complex I assembly (GO:0032981)3.12635107
76NADH dehydrogenase complex assembly (GO:0010257)3.12635107
77mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.12635107
78cerebellar granule cell differentiation (GO:0021707)3.12119188
79positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.11402935
80exploration behavior (GO:0035640)3.11186413
81postsynaptic membrane organization (GO:0001941)3.10305262
82* regulation of postsynaptic membrane potential (GO:0060078)3.07888271
83long-term synaptic potentiation (GO:0060291)3.06018389
84detection of calcium ion (GO:0005513)3.05464147
85negative regulation of gene silencing (GO:0060969)3.04387654
86positive regulation of neurotransmitter transport (GO:0051590)3.03408294
87regulation of DNA endoreduplication (GO:0032875)3.00183643
88long-term memory (GO:0007616)2.99450489
89behavioral response to cocaine (GO:0048148)2.97250846
90neurotransmitter secretion (GO:0007269)2.96580389
91activation of protein kinase A activity (GO:0034199)2.96095070
92adult heart development (GO:0007512)2.95502305
93regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.94485259
94epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.91841220
95regulation of dendritic spine morphogenesis (GO:0061001)2.90380109
96regulation of synapse structural plasticity (GO:0051823)2.89705769
97neuromuscular process controlling posture (GO:0050884)2.89374598
98regulation of synaptic plasticity (GO:0048167)2.89068756
99norepinephrine metabolic process (GO:0042415)2.89034926
100negative regulation of platelet activation (GO:0010544)2.87995013
101water-soluble vitamin biosynthetic process (GO:0042364)2.87798254
102sodium ion export (GO:0071436)2.86872761
103* regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.86798074
104cellular response to ATP (GO:0071318)2.85881552
105axonal fasciculation (GO:0007413)2.84138886
106regulation of dendritic spine development (GO:0060998)2.84079209
107behavioral defense response (GO:0002209)2.82546100
108behavioral fear response (GO:0001662)2.82546100
109regulation of synaptic transmission, glutamatergic (GO:0051966)2.82543923
110relaxation of cardiac muscle (GO:0055119)2.82508305
111cytidine metabolic process (GO:0046087)2.81575377
112cytidine catabolic process (GO:0006216)2.81575377
113cytidine deamination (GO:0009972)2.81575377
114layer formation in cerebral cortex (GO:0021819)2.81252542
115cell communication involved in cardiac conduction (GO:0086065)2.79355526
116gamma-aminobutyric acid transport (GO:0015812)2.79316719
117protein complex biogenesis (GO:0070271)2.79133940
118potassium ion import (GO:0010107)2.77849776
119regulation of vesicle fusion (GO:0031338)2.76801876
120lymphangiogenesis (GO:0001946)2.75421674
121negative regulation of peptidyl-lysine acetylation (GO:2000757)2.75288346
122regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.72299853
123artery development (GO:0060840)2.71274138
124dorsal/ventral axis specification (GO:0009950)2.70865608
125flavonoid metabolic process (GO:0009812)2.70689632
126thyroid hormone metabolic process (GO:0042403)2.70600460
127innervation (GO:0060384)2.69844448
128dendritic spine morphogenesis (GO:0060997)2.67565207
129regulation of action potential (GO:0098900)2.66304597
130regulation of fatty acid oxidation (GO:0046320)2.65783141
131positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.65260606
132positive regulation of synapse maturation (GO:0090129)2.64668011
133positive regulation of membrane potential (GO:0045838)2.64372636
134membrane depolarization (GO:0051899)2.64250499
135* fear response (GO:0042596)2.64035273
136regulation of oxidative phosphorylation (GO:0002082)2.63999295
137positive regulation of metanephros development (GO:0072216)2.63389272
138regulation of membrane repolarization (GO:0060306)2.63106421
139membrane depolarization during action potential (GO:0086010)2.62158468
140* adrenergic receptor signaling pathway (GO:0071875)2.62080727
141regulation of cell communication by electrical coupling (GO:0010649)2.61639532
142neuronal action potential (GO:0019228)2.60027390
143regulation of neurotransmitter secretion (GO:0046928)2.59506396
144neurotransmitter transport (GO:0006836)2.59430817
145regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.57367885
146positive regulation of triglyceride biosynthetic process (GO:0010867)2.56557011
147positive regulation of potassium ion transmembrane transport (GO:1901381)2.55507764
148synaptic vesicle endocytosis (GO:0048488)2.55024996
149cardiac muscle hypertrophy (GO:0003300)2.54966501
150regulation of calcium ion transmembrane transporter activity (GO:1901019)2.54935583
151regulation of calcium ion transmembrane transport (GO:1903169)2.54935583
152long term synaptic depression (GO:0060292)2.54846253
153muscle adaptation (GO:0043500)2.54535929
154heparin metabolic process (GO:0030202)2.53457603
155heparin biosynthetic process (GO:0030210)2.53457603
156regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.51818572
157cardiac muscle hypertrophy in response to stress (GO:0014898)2.51717474
158muscle hypertrophy in response to stress (GO:0003299)2.51717474
159cardiac muscle adaptation (GO:0014887)2.51717474
160cardiac myofibril assembly (GO:0055003)2.51593990
161negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.51047722
162startle response (GO:0001964)2.48980712
163mitochondrial respiratory chain complex assembly (GO:0033108)2.48501753
164positive regulation of synapse assembly (GO:0051965)2.47334218
165multicellular organismal movement (GO:0050879)2.46849044
166musculoskeletal movement (GO:0050881)2.46849044
167DNA replication-dependent nucleosome organization (GO:0034723)2.43969597
168DNA replication-dependent nucleosome assembly (GO:0006335)2.43969597
169cardiac conduction (GO:0061337)2.43643611
170phenol-containing compound catabolic process (GO:0019336)2.41192762
171hair cycle (GO:0042633)2.40829548
172molting cycle (GO:0042303)2.40829548
173negative regulation of cardiac muscle tissue development (GO:0055026)2.40640124
174cell differentiation in hindbrain (GO:0021533)2.40441864
175multicellular organismal signaling (GO:0035637)2.39554844
176estrogen metabolic process (GO:0008210)2.37188100
177regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)2.36719175
178negative regulation of transcription regulatory region DNA binding (GO:2000678)2.36660484
179negative regulation of appetite (GO:0032099)2.36545059
180negative regulation of response to food (GO:0032096)2.36545059
181protein polyglutamylation (GO:0018095)2.36071528
182cardiac muscle cell action potential involved in contraction (GO:0086002)2.34622467

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse9.17085110
2EZH2_22144423_ChIP-Seq_EOC_Human5.05045212
3BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse4.00630688
4GBX2_23144817_ChIP-Seq_PC3_Human3.65251259
5STAT6_21828071_ChIP-Seq_BEAS2B_Human3.19155595
6* SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.04346675
7* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.00305904
8HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.81219357
9* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.80697361
10* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.59629551
11* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.57531527
12* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.57531527
13* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.53313306
14* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.48670949
15* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.39517223
16* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.39352291
17* EED_16625203_ChIP-ChIP_MESCs_Mouse2.39179530
18* EZH2_27304074_Chip-Seq_ESCs_Mouse2.32831445
19* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.27045329
20DROSHA_22980978_ChIP-Seq_HELA_Human2.14198302
21* RNF2_27304074_Chip-Seq_ESCs_Mouse2.02527739
22RARB_27405468_Chip-Seq_BRAIN_Mouse2.01706083
23* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.00558990
24REST_21632747_ChIP-Seq_MESCs_Mouse1.99116938
25TAF15_26573619_Chip-Seq_HEK293_Human1.98474252
26EZH2_27294783_Chip-Seq_ESCs_Mouse1.98002254
27VDR_22108803_ChIP-Seq_LS180_Human1.94309181
28CTBP1_25329375_ChIP-Seq_LNCAP_Human1.78975881
29AR_21572438_ChIP-Seq_LNCaP_Human1.72712184
30CTBP2_25329375_ChIP-Seq_LNCAP_Human1.72259492
31PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.71095736
32IKZF1_21737484_ChIP-ChIP_HCT116_Human1.68447103
33SMAD4_21799915_ChIP-Seq_A2780_Human1.62167951
34CDX2_19796622_ChIP-Seq_MESCs_Mouse1.61223571
35REST_18959480_ChIP-ChIP_MESCs_Mouse1.58960997
36GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.54955750
37SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.52948796
38ZFP57_27257070_Chip-Seq_ESCs_Mouse1.51082473
39SMAD_19615063_ChIP-ChIP_OVARY_Human1.49583534
40P300_19829295_ChIP-Seq_ESCs_Human1.44511067
41ER_23166858_ChIP-Seq_MCF-7_Human1.43485740
42EP300_21415370_ChIP-Seq_HL-1_Mouse1.43309609
43ZNF274_21170338_ChIP-Seq_K562_Hela1.42948739
44PIAS1_25552417_ChIP-Seq_VCAP_Human1.42133583
45NR3C1_23031785_ChIP-Seq_PC12_Mouse1.42028298
46* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.40372803
47* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.39850875
48SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.36469956
49GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.36440706
50* TP53_16413492_ChIP-PET_HCT116_Human1.36375408
51SMAD3_21741376_ChIP-Seq_EPCs_Human1.36113876
52ARNT_22903824_ChIP-Seq_MCF-7_Human1.35731821
53AHR_22903824_ChIP-Seq_MCF-7_Human1.35234818
54EWS_26573619_Chip-Seq_HEK293_Human1.32101727
55POU5F1_16153702_ChIP-ChIP_HESCs_Human1.31788104
56EGR1_23403033_ChIP-Seq_LIVER_Mouse1.31350172
57* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.31018014
58ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.30740745
59BCAT_22108803_ChIP-Seq_LS180_Human1.28815389
60TOP2B_26459242_ChIP-Seq_MCF-7_Human1.27730896
61POU3F2_20337985_ChIP-ChIP_501MEL_Human1.26990089
62SOX2_21211035_ChIP-Seq_LN229_Gbm1.24457095
63ERG_21242973_ChIP-ChIP_JURKAT_Human1.22986654
64RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.22983831
65AR_25329375_ChIP-Seq_VCAP_Human1.22949458
66* RING1B_27294783_Chip-Seq_ESCs_Mouse1.21972744
67* CBX2_27304074_Chip-Seq_ESCs_Mouse1.21791602
68SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.20732449
69* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.20415709
70RNF2_27304074_Chip-Seq_NSC_Mouse1.19635939
71TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.17945359
72TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.17103168
73OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.16144977
74SMAD3_21741376_ChIP-Seq_HESCs_Human1.15888079
75EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.15546647
76* AR_19668381_ChIP-Seq_PC3_Human1.14937850
77FUS_26573619_Chip-Seq_HEK293_Human1.14737480
78STAT3_23295773_ChIP-Seq_U87_Human1.14158009
79* TP53_18474530_ChIP-ChIP_U2OS_Human1.13818897
80BMI1_23680149_ChIP-Seq_NPCS_Mouse1.13686002
81MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.13267133
82ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.12245073
83ESR1_21235772_ChIP-Seq_MCF-7_Human1.12069208
84CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.11808369
85CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.10308201
86MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.09648832
87ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.09454449
88WT1_25993318_ChIP-Seq_PODOCYTE_Human1.09074114
89* PRDM14_20953172_ChIP-Seq_ESCs_Human1.07993805
90NR3C1_21868756_ChIP-Seq_MCF10A_Human1.07480774
91AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.06487710
92NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.04772758
93RING1B_27294783_Chip-Seq_NPCs_Mouse1.04423765
94P53_22127205_ChIP-Seq_FIBROBLAST_Human1.04398324
95TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.01585725
96TCF4_23295773_ChIP-Seq_U87_Human0.99511539
97* RUNX2_22187159_ChIP-Seq_PCA_Human0.99202181
98EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.98809895
99IGF1R_20145208_ChIP-Seq_DFB_Human0.98333354
100TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.98291720
101TDRD3_21172665_ChIP-Seq_MCF-7_Human0.97803913
102RXR_22108803_ChIP-Seq_LS180_Human0.96495811
103SMAD4_21741376_ChIP-Seq_HESCs_Human0.95580857
104FLI1_21867929_ChIP-Seq_TH2_Mouse0.93847910
105PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.92148287
106DNAJC2_21179169_ChIP-ChIP_NT2_Human0.91826490
107BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.91467102
108* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.90647292
109WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.90593461
110LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.90494563
111POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.89025839
112TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89025839
113TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88750919
114* KDM2B_26808549_Chip-Seq_REH_Human0.87777325
115* AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.87420935
116SMAD4_21741376_ChIP-Seq_EPCs_Human0.86490256
117CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.86322230
118TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.86204157
119* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.86130912
120FOXM1_26456572_ChIP-Seq_MCF-7_Human0.85763357
121CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85142877
122ESR1_20079471_ChIP-ChIP_T-47D_Human0.85105105
123IRF1_19129219_ChIP-ChIP_H3396_Human0.84996592
124TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.84532934
125RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.84342789
126NANOG_16153702_ChIP-ChIP_HESCs_Human0.84131020
127SOX2_16153702_ChIP-ChIP_HESCs_Human0.82328701
128FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.81648677
129MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.80216772

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.00015462
2MP0003880_abnormal_central_pattern4.88035377
3MP0003635_abnormal_synaptic_transmissio3.49178166
4MP0002837_dystrophic_cardiac_calcinosis3.21556585
5MP0005171_absent_coat_pigmentation3.20057843
6MP0009745_abnormal_behavioral_response3.03419200
7MP0004270_analgesia3.02200638
8MP0002063_abnormal_learning/memory/cond2.75543691
9MP0002064_seizures2.72625424
10MP0001968_abnormal_touch/_nociception2.59399938
11MP0005670_abnormal_white_adipose2.48486575
12MP0004215_abnormal_myocardial_fiber2.41782825
13MP0002572_abnormal_emotion/affect_behav2.37436222
14MP0009046_muscle_twitch2.36816312
15MP0001485_abnormal_pinna_reflex2.33938525
16MP0005083_abnormal_biliary_tract2.30147366
17MP0001501_abnormal_sleep_pattern2.26937936
18MP0002138_abnormal_hepatobiliary_system2.25576814
19MP0001486_abnormal_startle_reflex2.21171730
20MP0005551_abnormal_eye_electrophysiolog2.18666198
21MP0002272_abnormal_nervous_system2.14600463
22MP0000751_myopathy2.14509704
23MP0002736_abnormal_nociception_after2.14234940
24MP0006292_abnormal_olfactory_placode2.13140435
25MP0002163_abnormal_gland_morphology2.09898053
26MP0004134_abnormal_chest_morphology2.07746094
27MP0005503_abnormal_tendon_morphology2.04055617
28MP0005423_abnormal_somatic_nervous1.96216805
29MP0001440_abnormal_grooming_behavior1.92569843
30MP0009780_abnormal_chondrocyte_physiolo1.83753268
31MP0004484_altered_response_of1.82262103
32MP0000631_abnormal_neuroendocrine_gland1.81276998
33MP0003329_amyloid_beta_deposits1.79796807
34MP0002067_abnormal_sensory_capabilities1.73647237
35MP0002295_abnormal_pulmonary_circulatio1.73607725
36MP0002734_abnormal_mechanical_nocicepti1.73314123
37MP0004084_abnormal_cardiac_muscle1.72230629
38* MP0004085_abnormal_heartbeat1.72008738
39MP0002160_abnormal_reproductive_system1.71045313
40MP0009697_abnormal_copulation1.71030374
41MP0002822_catalepsy1.68912878
42MP0000049_abnormal_middle_ear1.67645182
43MP0004036_abnormal_muscle_relaxation1.65018650
44MP0003646_muscle_fatigue1.64691089
45MP0005379_endocrine/exocrine_gland_phen1.64653698
46MP0004145_abnormal_muscle_electrophysio1.63373883
47MP0005330_cardiomyopathy1.62055332
48MP0004510_myositis1.58432995
49MP0002735_abnormal_chemical_nociception1.58185434
50MP0008569_lethality_at_weaning1.56565059
51MP0006138_congestive_heart_failure1.55736634
52MP0002090_abnormal_vision1.54271277
53MP0004133_heterotaxia1.52925806
54MP0005167_abnormal_blood-brain_barrier1.52681198
55MP0004858_abnormal_nervous_system1.44903058
56MP0002876_abnormal_thyroid_physiology1.44125381
57* MP0002972_abnormal_cardiac_muscle1.42307690
58MP0002557_abnormal_social/conspecific_i1.39135325
59MP0003137_abnormal_impulse_conducting1.38741379
60MP0000372_irregular_coat_pigmentation1.38539006
61MP0002139_abnormal_hepatobiliary_system1.38026487
62MP0005386_behavior/neurological_phenoty1.37613734
63MP0004924_abnormal_behavior1.37613734
64MP0003633_abnormal_nervous_system1.35969098
65MP0004233_abnormal_muscle_weight1.35118792
66MP0001970_abnormal_pain_threshold1.34052165
67* MP0005620_abnormal_muscle_contractility1.34001164
68MP0006072_abnormal_retinal_apoptosis1.33544863
69MP0000778_abnormal_nervous_system1.31284890
70MP0000613_abnormal_salivary_gland1.29314536
71MP0002638_abnormal_pupillary_reflex1.28073992
72MP0002733_abnormal_thermal_nociception1.25855938
73MP0001984_abnormal_olfaction1.23377162
74MP0002909_abnormal_adrenal_gland1.21753105
75MP0008877_abnormal_DNA_methylation1.21251194
76MP0003879_abnormal_hair_cell1.20545718
77MP0000749_muscle_degeneration1.17776987
78* MP0008872_abnormal_physiological_respon1.17098708
79MP0005253_abnormal_eye_physiology1.15890393
80MP0001502_abnormal_circadian_rhythm1.15476823
81MP0004130_abnormal_muscle_cell1.14650346
82MP0003828_pulmonary_edema1.13840876
83MP0002882_abnormal_neuron_morphology1.13267320
84MP0002184_abnormal_innervation1.11828277
85MP0002127_abnormal_cardiovascular_syste1.11164094
86MP0002332_abnormal_exercise_endurance1.09163890
87MP0002066_abnormal_motor_capabilities/c1.08559184
88MP0003690_abnormal_glial_cell1.08391259
89MP0005389_reproductive_system_phenotype1.08270014
90MP0001905_abnormal_dopamine_level1.07140697
91MP0003075_altered_response_to1.06723148
92MP0001188_hyperpigmentation1.06651491
93MP0003787_abnormal_imprinting1.05709077
94MP0005645_abnormal_hypothalamus_physiol1.05085182
95MP0009384_cardiac_valve_regurgitation1.03894217
96MP0004885_abnormal_endolymph1.03683760
97MP0002229_neurodegeneration1.02835897
98MP0003631_nervous_system_phenotype1.02083548
99MP0006276_abnormal_autonomic_nervous1.01781313
100MP0000678_abnormal_parathyroid_gland1.01303216
101MP0009250_abnormal_appendicular_skeleto1.00410795
102MP0002108_abnormal_muscle_morphology0.97884305
103MP0005595_abnormal_vascular_smooth0.97433810
104MP0004087_abnormal_muscle_fiber0.95572072
105MP0005646_abnormal_pituitary_gland0.93498107
106MP0004811_abnormal_neuron_physiology0.92631953
107* MP0005385_cardiovascular_system_phenoty0.91368882
108* MP0001544_abnormal_cardiovascular_syste0.91368882
109* MP0005535_abnormal_body_temperature0.91253743
110MP0005084_abnormal_gallbladder_morpholo0.90979216
111MP0005623_abnormal_meninges_morphology0.89764246
112MP0008874_decreased_physiological_sensi0.88021705
113MP0000955_abnormal_spinal_cord0.80484882
114MP0005165_increased_susceptibility_to0.79998271
115MP0010368_abnormal_lymphatic_system0.79492925
116MP0001963_abnormal_hearing_physiology0.78277973
117MP0000013_abnormal_adipose_tissue0.78052703
118MP0004142_abnormal_muscle_tone0.77712293
119MP0000026_abnormal_inner_ear0.77624712
120MP0002106_abnormal_muscle_physiology0.77281992
121MP0003938_abnormal_ear_development0.76977750
122MP0004742_abnormal_vestibular_system0.76570868
123MP0005409_darkened_coat_color0.76278481
124MP0003950_abnormal_plasma_membrane0.75598235
125MP0005195_abnormal_posterior_eye0.75251378
126MP0001944_abnormal_pancreas_morphology0.74632058
127MP0008775_abnormal_heart_ventricle0.73982485
128MP0002152_abnormal_brain_morphology0.73654531
129MP0002653_abnormal_ependyma_morphology0.73126267
130MP0001177_atelectasis0.73023503
131MP0000604_amyloidosis0.72927958
132MP0003937_abnormal_limbs/digits/tail_de0.72888150
133MP0002928_abnormal_bile_duct0.72886281
134MP0005448_abnormal_energy_balance0.70865024
135MP0005310_abnormal_salivary_gland0.70694175
136MP0002752_abnormal_somatic_nervous0.70416662
137MP0000230_abnormal_systemic_arterial0.70152892
138MP0010386_abnormal_urinary_bladder0.69712103
139MP0003195_calcinosis0.69177995

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.85836116
2Epileptic encephalopathy (HP:0200134)5.20318900
3Focal seizures (HP:0007359)4.65903581
4Atonic seizures (HP:0010819)4.61579295
5Hyperventilation (HP:0002883)4.33088356
6Sudden death (HP:0001699)4.19803853
7Absence seizures (HP:0002121)4.09315456
8Pendular nystagmus (HP:0012043)4.08098531
9Syncope (HP:0001279)3.92544735
10Febrile seizures (HP:0002373)3.86604218
11Visual hallucinations (HP:0002367)3.83756889
12Myokymia (HP:0002411)3.80851530
13Anomalous pulmonary venous return (HP:0010772)3.78785378
14Dyschromatopsia (HP:0007641)3.67669098
15Generalized tonic-clonic seizures (HP:0002069)3.62972745
16Dialeptic seizures (HP:0011146)3.60833299
17Abnormality of the pulmonary veins (HP:0011718)3.58591877
18Calf muscle hypertrophy (HP:0008981)3.33616539
19Short phalanx of the thumb (HP:0009660)3.31159657
20Muscle hypertrophy of the lower extremities (HP:0008968)3.27514781
21Neoplasm of the heart (HP:0100544)3.25962283
22Type II lissencephaly (HP:0007260)3.20187410
23Broad-based gait (HP:0002136)3.18177685
24Atrial fibrillation (HP:0005110)3.17937513
25Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.12994446
26Short 4th metacarpal (HP:0010044)3.12994446
27True hermaphroditism (HP:0010459)3.12424796
28Dysdiadochokinesis (HP:0002075)3.09567626
29Primary atrial arrhythmia (HP:0001692)3.07960071
30Abnormality of the calf musculature (HP:0001430)3.02523966
31Progressive cerebellar ataxia (HP:0002073)2.98867037
32Pancreatic fibrosis (HP:0100732)2.95155079
33Poor eye contact (HP:0000817)2.92040352
34Supraventricular tachycardia (HP:0004755)2.91978681
35Methylmalonic acidemia (HP:0002912)2.89915654
36Supraventricular arrhythmia (HP:0005115)2.89124685
373-Methylglutaconic aciduria (HP:0003535)2.82974342
38Hypothermia (HP:0002045)2.81001319
39Amblyopia (HP:0000646)2.79550874
40Cerebral inclusion bodies (HP:0100314)2.79088121
41Abolished electroretinogram (ERG) (HP:0000550)2.71955273
42Prolonged QT interval (HP:0001657)2.66103799
43Congenital stationary night blindness (HP:0007642)2.63796740
44Diplopia (HP:0000651)2.62507855
45Abnormality of binocular vision (HP:0011514)2.62507855
46Excessive salivation (HP:0003781)2.61919007
47Drooling (HP:0002307)2.61919007
48Hemiparesis (HP:0001269)2.61241945
49Congenital sensorineural hearing impairment (HP:0008527)2.60850970
50Absent/shortened dynein arms (HP:0200106)2.60770527
51Dynein arm defect of respiratory motile cilia (HP:0012255)2.60770527
52Pancreatic cysts (HP:0001737)2.60473252
53Exercise-induced myalgia (HP:0003738)2.59703819
54Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)2.58902110
55Impaired social interactions (HP:0000735)2.57120693
56Abnormal social behavior (HP:0012433)2.57120693
57Down-sloping shoulders (HP:0200021)2.56440186
58Abnormality of the parietal bone (HP:0002696)2.55833202
59Hemiplegia (HP:0002301)2.54820624
60Abnormality of the 4th metacarpal (HP:0010012)2.54057511
61Neurofibrillary tangles (HP:0002185)2.51188316
62Central scotoma (HP:0000603)2.50381566
63Vertebral fusion (HP:0002948)2.47092761
64Gaze-evoked nystagmus (HP:0000640)2.46698632
65Nephronophthisis (HP:0000090)2.44146914
66Deformed sella turcica (HP:0002681)2.42588675
67Anxiety (HP:0000739)2.42531187
68Split foot (HP:0001839)2.42199034
69Dysmetria (HP:0001310)2.41169651
70Inability to walk (HP:0002540)2.39785275
71Abnormality of the nasal septum (HP:0000419)2.38960470
72Abnormality of macular pigmentation (HP:0008002)2.38541355
73Abnormality of homocysteine metabolism (HP:0010919)2.38166715
74Homocystinuria (HP:0002156)2.38166715
75Truncal ataxia (HP:0002078)2.34474084
76Abnormality of the renal cortex (HP:0011035)2.34203845
77Thickened helices (HP:0000391)2.33204937
78Increased corneal curvature (HP:0100692)2.33094712
79Keratoconus (HP:0000563)2.33094712
80Supranuclear gaze palsy (HP:0000605)2.32985602
81Abnormality of midbrain morphology (HP:0002418)2.32635295
82Molar tooth sign on MRI (HP:0002419)2.32635295
83Bundle branch block (HP:0011710)2.30083240
84Aplasia involving bones of the upper limbs (HP:0009823)2.28157155
85Aplasia of the phalanges of the hand (HP:0009802)2.28157155
86Aplasia involving bones of the extremities (HP:0009825)2.28157155
87Status epilepticus (HP:0002133)2.27021596
88Epileptiform EEG discharges (HP:0011182)2.25749582
89Abnormal EKG (HP:0003115)2.23454430
90Ventricular fibrillation (HP:0001663)2.22451105
91Oligodactyly (hands) (HP:0001180)2.22007896
92Dysmetric saccades (HP:0000641)2.20737367
93Depression (HP:0000716)2.20560530
94Absent speech (HP:0001344)2.19960245
95Posterior subcapsular cataract (HP:0007787)2.19109306
96Confusion (HP:0001289)2.18963649
97Methylmalonic aciduria (HP:0012120)2.18456311
98Spinal muscular atrophy (HP:0007269)2.17470908
99Cerebellar dysplasia (HP:0007033)2.16148768
100Progressive inability to walk (HP:0002505)2.15578349
101Broad ribs (HP:0000885)2.15124960
102Rapidly progressive (HP:0003678)2.13481456
103Absent rod-and cone-mediated responses on ERG (HP:0007688)2.13106214
104Hydroureter (HP:0000072)2.10993942
105Choroideremia (HP:0001139)2.09579794
106Abnormality of ocular smooth pursuit (HP:0000617)2.09357973
107Ventricular tachycardia (HP:0004756)2.06908154
108Renal cortical cysts (HP:0000803)2.06876196
109Hamartoma of the eye (HP:0010568)2.06864880
110Action tremor (HP:0002345)2.06571062
111Urinary bladder sphincter dysfunction (HP:0002839)2.05169436
112Optic disc pallor (HP:0000543)2.04999172
113Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.03541323
114Stereotypic behavior (HP:0000733)2.03044763
115Congenital, generalized hypertrichosis (HP:0004540)2.02431411
116EEG with generalized epileptiform discharges (HP:0011198)2.02137722
117Arterial tortuosity (HP:0005116)2.00967372
118Porencephaly (HP:0002132)2.00495401
119Abnormal respiratory epithelium morphology (HP:0012253)1.99877238
120Abnormal respiratory motile cilium morphology (HP:0005938)1.99877238
121Genetic anticipation (HP:0003743)1.99761273
122Late onset (HP:0003584)1.99576172
123Ventricular arrhythmia (HP:0004308)1.99528769
124Abnormality of the sella turcica (HP:0002679)1.98424005
125Cerebral hemorrhage (HP:0001342)1.97488146
126Left ventricular hypertrophy (HP:0001712)1.97354990
127Severe muscular hypotonia (HP:0006829)1.96872619
128Postural instability (HP:0002172)1.95642177
129Impaired smooth pursuit (HP:0007772)1.95126382
130Hypoplastic nipples (HP:0002557)1.94965824
131Hepatocellular necrosis (HP:0001404)1.94534456
132Athetosis (HP:0002305)1.92917049
133Impaired vibration sensation in the lower limbs (HP:0002166)1.92095428
134Acute necrotizing encephalopathy (HP:0006965)1.92055072
135Scotoma (HP:0000575)1.91830519
136Mitochondrial inheritance (HP:0001427)1.91056194
137Insidious onset (HP:0003587)1.90145864
138Termporal pattern (HP:0011008)1.90145864
139Goiter (HP:0000853)1.89922122
140Carpal bone hypoplasia (HP:0001498)1.89717317
141Septo-optic dysplasia (HP:0100842)1.88940481
142Neoplasm of the oral cavity (HP:0100649)1.88916548
143Pheochromocytoma (HP:0002666)1.88768247
144Decreased electroretinogram (ERG) amplitude (HP:0000654)1.87911462
145Chorioretinal atrophy (HP:0000533)1.87778013
146Abnormal eating behavior (HP:0100738)1.87221284
147Furrowed tongue (HP:0000221)1.86619928
148Severe visual impairment (HP:0001141)1.86018362
149EMG: myopathic abnormalities (HP:0003458)1.85852841
150Oral leukoplakia (HP:0002745)1.85405664
151Agitation (HP:0000713)1.84660234
152Abnormality of vitamin B metabolism (HP:0004340)1.84343543
153Hypoplasia of the uterus (HP:0000013)1.83931081
154Abnormal ciliary motility (HP:0012262)1.83813683
155Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.83492630
156Short 1st metacarpal (HP:0010034)1.83492630
157Tachypnea (HP:0002789)1.83134238
158Generalized myoclonic seizures (HP:0002123)1.82997907
159Abnormality of the renal medulla (HP:0100957)1.81561326
160Cystic liver disease (HP:0006706)1.81450470
161Retinal atrophy (HP:0001105)1.81149743
162Hypoplasia of the pons (HP:0012110)1.78941693
163Obstructive sleep apnea (HP:0002870)1.78674892
164Humeroradial synostosis (HP:0003041)1.78604545
165Synostosis involving the elbow (HP:0003938)1.78604545
166Retinal dysplasia (HP:0007973)1.78389180
167Male pseudohermaphroditism (HP:0000037)1.78339338
168Progressive macrocephaly (HP:0004481)1.78097564
169Abnormality of salivation (HP:0100755)1.78062306
170Decreased circulating renin level (HP:0003351)1.77830292
171Optic nerve hypoplasia (HP:0000609)1.77587319
172Abnormal mitochondria in muscle tissue (HP:0008316)1.77297594
173Subaortic stenosis (HP:0001682)1.75932019

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.80652892
2FRK3.96309120
3NTRK33.71695613
4ADRBK23.45708494
5CASK3.07248233
6EPHA32.99396316
7RIPK42.89495554
8MAP3K42.59851754
9MAP3K92.38009088
10DAPK22.32552817
11MAP2K72.22174475
12MYLK1.91617947
13GRK71.90382161
14PLK21.89015527
15LMTK21.88262506
16PTK2B1.86621880
17PRKCI1.78344960
18GRK51.78301945
19MAP2K41.76324566
20BMPR1B1.72499885
21VRK11.72199843
22STK41.71548462
23BMPR21.69857819
24PRKD21.69564792
25DMPK1.69421786
26MINK11.63216935
27AKT31.62508847
28PNCK1.60559061
29ZAK1.60453954
30PAK61.58922744
31TLK11.54081768
32MAP3K121.52865797
33SIK21.42463842
34MAP3K131.38787889
35KSR21.36275349
36ACVR1B1.34438628
37CAMK2A1.31722584
38NTRK21.29639693
39FES1.28392749
40MAPK121.28052183
41FGR1.27716852
42DAPK11.26802555
43CDK51.25867669
44STK381.24066951
45PHKG21.16026921
46PHKG11.16026921
47MAP4K21.15530550
48INSRR1.15035554
49TNIK1.13144224
50MARK11.12113186
51PAK31.09090733
52PDK21.08956691
53TAOK31.08275881
54TAF11.07491865
55TGFBR21.07475789
56TIE11.05622554
57PRPF4B1.03401526
58NTRK11.01021912
59MAP2K60.99775605
60CAMK10.99491956
61FGFR20.98377943
62PRKAA10.98133300
63PDK40.96460047
64PDK30.96460047
65PINK10.93043745
66CAMKK10.92254375
67CAMK2B0.91998709
68CAMK2D0.91109368
69CCNB10.90695373
70PRKCE0.90160299
71PKN10.88777470
72NUAK10.87720039
73MST40.87470706
74KSR10.85694366
75MAPK70.85349858
76FER0.84933257
77NME10.84064252
78CAMK1D0.83491263
79WNK30.83329875
80PRKD30.83055557
81CAMK1G0.81914319
82MAPKAPK30.81246522
83PRKCG0.80253380
84GRK10.79451560
85MAP3K20.77580194
86RPS6KA50.76662056
87RAF10.73245501
88SGK10.72614936
89CSNK1G10.72393265
90CDK190.71635217
91AURKA0.70725449
92ARAF0.68445716
93MAP3K10.67499624
94SGK4940.67133050
95SGK2230.67133050
96MAPK130.66288555
97PDK10.66026872
98PDPK10.66008383
99DYRK1A0.65621509
100SGK20.64944594
101MOS0.62623430
102TNK20.62097508
103CDC42BPA0.60535843
104MAP3K70.60425938
105PRKCZ0.58936644
106RET0.58914290
107CDK30.58878594
108MUSK0.56621528
109DAPK30.56218862
110STK110.55170169
111ROCK20.54520575
112CDK180.54327853
113MAPK150.54210376
114CDK150.53553936
115MAP2K10.53434296
116PRKD10.53375490
117CAMK2G0.52567398
118* PRKACA0.51821351
119MAPKAPK50.51300120
120OBSCN0.51197033
121PRKCQ0.51169521
122TEC0.50993728
123CSNK1A1L0.50594493
124BRSK20.50077776
125ADRBK10.50054987
126CSNK1A10.49984363
127PRKCH0.49305933
128MARK20.48255911
129CDK140.48148925
130MAP3K60.47846507
131TTN0.47814454
132RPS6KA60.47663869
133CSNK1G30.47283510
134OXSR10.47110675
135UHMK10.43844675
136CAMK40.43711516
137CSNK1G20.43333513
138STK390.43144583
139PIK3CA0.42707218
140ROCK10.42279558
141RPS6KA30.41835150
142PRKCA0.38761543
143SGK30.36805391

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.19820171
2Phototransduction_Homo sapiens_hsa047442.87077330
3Systemic lupus erythematosus_Homo sapiens_hsa053222.82578085
4Selenocompound metabolism_Homo sapiens_hsa004502.74461608
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.51711408
6Circadian entrainment_Homo sapiens_hsa047132.46601340
7Long-term potentiation_Homo sapiens_hsa047202.45048627
8Alcoholism_Homo sapiens_hsa050342.44189508
9Glutamatergic synapse_Homo sapiens_hsa047242.34660274
10Morphine addiction_Homo sapiens_hsa050322.33794193
11GABAergic synapse_Homo sapiens_hsa047272.29898300
12Synaptic vesicle cycle_Homo sapiens_hsa047212.28658296
13* Salivary secretion_Homo sapiens_hsa049702.24171710
14Olfactory transduction_Homo sapiens_hsa047402.16467002
15Amphetamine addiction_Homo sapiens_hsa050312.11749433
16Maturity onset diabetes of the young_Homo sapiens_hsa049502.06089552
17Tryptophan metabolism_Homo sapiens_hsa003801.99704257
18* Renin secretion_Homo sapiens_hsa049241.98202172
19Gastric acid secretion_Homo sapiens_hsa049711.90833519
20Cardiac muscle contraction_Homo sapiens_hsa042601.90410515
21Oxytocin signaling pathway_Homo sapiens_hsa049211.80486657
22Taste transduction_Homo sapiens_hsa047421.77664792
23Insulin secretion_Homo sapiens_hsa049111.76810612
24Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.74657075
25* Calcium signaling pathway_Homo sapiens_hsa040201.68494283
26Dopaminergic synapse_Homo sapiens_hsa047281.67764060
27* Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.64014043
28Aldosterone synthesis and secretion_Homo sapiens_hsa049251.62396483
29Serotonergic synapse_Homo sapiens_hsa047261.61156999
30* Dilated cardiomyopathy_Homo sapiens_hsa054141.56796216
31Cholinergic synapse_Homo sapiens_hsa047251.55288437
32Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.55223428
33Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.52863290
34Collecting duct acid secretion_Homo sapiens_hsa049661.47862978
35Long-term depression_Homo sapiens_hsa047301.45805180
36Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.35861488
37* cGMP-PKG signaling pathway_Homo sapiens_hsa040221.34382835
38* cAMP signaling pathway_Homo sapiens_hsa040241.33718424
39Oxidative phosphorylation_Homo sapiens_hsa001901.27177562
40GnRH signaling pathway_Homo sapiens_hsa049121.26973054
41Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.22272043
42Linoleic acid metabolism_Homo sapiens_hsa005911.21256409
43Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.20687441
44Alzheimers disease_Homo sapiens_hsa050101.20175557
45Cocaine addiction_Homo sapiens_hsa050301.18192016
46Vascular smooth muscle contraction_Homo sapiens_hsa042701.17182011
47Basal cell carcinoma_Homo sapiens_hsa052171.15350154
48* Gap junction_Homo sapiens_hsa045401.12416418
49Sulfur metabolism_Homo sapiens_hsa009201.10172004
50Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.10045591
51Hedgehog signaling pathway_Homo sapiens_hsa043401.09190456
52Histidine metabolism_Homo sapiens_hsa003401.08628373
53alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.07407371
54Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.06564326
55Estrogen signaling pathway_Homo sapiens_hsa049151.01435232
56Pancreatic secretion_Homo sapiens_hsa049721.00143606
57Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.98968042
58Melanogenesis_Homo sapiens_hsa049160.97083648
59Melanoma_Homo sapiens_hsa052180.95060758
60Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.93983690
61* Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.92298326
62Chemical carcinogenesis_Homo sapiens_hsa052040.91517811
63Phosphatidylinositol signaling system_Homo sapiens_hsa040700.90337466
64Axon guidance_Homo sapiens_hsa043600.89945155
65Vibrio cholerae infection_Homo sapiens_hsa051100.88354766
66beta-Alanine metabolism_Homo sapiens_hsa004100.88023170
67Vitamin digestion and absorption_Homo sapiens_hsa049770.87604700
68Parkinsons disease_Homo sapiens_hsa050120.86380646
69Homologous recombination_Homo sapiens_hsa034400.84923509
70Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.82847497
71Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.82676779
72Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.82181802
73Glioma_Homo sapiens_hsa052140.78749179
74Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.78727358
75Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.78613188
76Fatty acid biosynthesis_Homo sapiens_hsa000610.78465846
77Type II diabetes mellitus_Homo sapiens_hsa049300.77692748
78Dorso-ventral axis formation_Homo sapiens_hsa043200.76186806
79Glycerolipid metabolism_Homo sapiens_hsa005610.76160124
80Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.75430313
81Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.74036702
82Butanoate metabolism_Homo sapiens_hsa006500.73618517
83* Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.73597142
84Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.72797983
85Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.69633660
86MAPK signaling pathway_Homo sapiens_hsa040100.69508328
87ErbB signaling pathway_Homo sapiens_hsa040120.68523718
88PPAR signaling pathway_Homo sapiens_hsa033200.68021559
89Glucagon signaling pathway_Homo sapiens_hsa049220.66651669
90African trypanosomiasis_Homo sapiens_hsa051430.64445079
91Folate biosynthesis_Homo sapiens_hsa007900.62969864
92VEGF signaling pathway_Homo sapiens_hsa043700.62171693
93Thyroid hormone synthesis_Homo sapiens_hsa049180.60407485
94Rap1 signaling pathway_Homo sapiens_hsa040150.59874470
95Phospholipase D signaling pathway_Homo sapiens_hsa040720.59565508
96Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.59365936
97Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.58043671
98Bile secretion_Homo sapiens_hsa049760.57762809
99Huntingtons disease_Homo sapiens_hsa050160.57719465
100Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.57560195
101Ether lipid metabolism_Homo sapiens_hsa005650.57469943
102Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.57274062
103Choline metabolism in cancer_Homo sapiens_hsa052310.55277849
104Steroid hormone biosynthesis_Homo sapiens_hsa001400.55015316
105Ras signaling pathway_Homo sapiens_hsa040140.54726907
106Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.52616016
107Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.52553926
108Fatty acid degradation_Homo sapiens_hsa000710.51396153
109Regulation of autophagy_Homo sapiens_hsa041400.51104839
110ABC transporters_Homo sapiens_hsa020100.50979221
111Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.50860216
112Prion diseases_Homo sapiens_hsa050200.48855785
113Renal cell carcinoma_Homo sapiens_hsa052110.47537504
114Circadian rhythm_Homo sapiens_hsa047100.46682255
115Hippo signaling pathway_Homo sapiens_hsa043900.46328989
116Nitrogen metabolism_Homo sapiens_hsa009100.45594802
117Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.44155641
118Renin-angiotensin system_Homo sapiens_hsa046140.43033415
119Inositol phosphate metabolism_Homo sapiens_hsa005620.41268732
120Thyroid hormone signaling pathway_Homo sapiens_hsa049190.41238472
1212-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.40077266
122Rheumatoid arthritis_Homo sapiens_hsa053230.38026459
123Wnt signaling pathway_Homo sapiens_hsa043100.35483711
124Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.34066759
125Platelet activation_Homo sapiens_hsa046110.33873841
126Carbohydrate digestion and absorption_Homo sapiens_hsa049730.33778073
127Regulation of actin cytoskeleton_Homo sapiens_hsa048100.32652856
128Sphingolipid signaling pathway_Homo sapiens_hsa040710.32576219
129Propanoate metabolism_Homo sapiens_hsa006400.29473783
130Mineral absorption_Homo sapiens_hsa049780.28886052
131AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.28030691
132Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.27277157
133Fatty acid metabolism_Homo sapiens_hsa012120.26930766
134Ovarian steroidogenesis_Homo sapiens_hsa049130.26191710
135Focal adhesion_Homo sapiens_hsa045100.25310552
136Chemokine signaling pathway_Homo sapiens_hsa040620.25271970
137Insulin signaling pathway_Homo sapiens_hsa049100.24513137

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