ADRA2C

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. The mouse studies revealed that both the alpha2A and alpha2C subtypes were required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons. The alpha2A subtype inhibited transmitter release at high stimulation frequencies, whereas the alpha2C subtype modulated neurotransmission at lower levels of nerve activity. This gene encodes the alpha2C subtype, which contains no introns in either its coding or untranslated sequences. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1locomotory exploration behavior (GO:0035641)5.90383841
2positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.75755319
3regulation of short-term neuronal synaptic plasticity (GO:0048172)5.72560407
4synaptic vesicle maturation (GO:0016188)5.33899648
5vocalization behavior (GO:0071625)5.31871846
6regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.25979586
7regulation of synapse structural plasticity (GO:0051823)5.00825528
8regulation of long-term neuronal synaptic plasticity (GO:0048169)4.97440361
9positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.96797178
10regulation of glutamate receptor signaling pathway (GO:1900449)4.95817552
11regulation of mammary gland epithelial cell proliferation (GO:0033599)4.85983051
12synaptic transmission, dopaminergic (GO:0001963)4.84000596
13regulation of branching involved in prostate gland morphogenesis (GO:0060687)4.73279953
14regulation of neuronal synaptic plasticity (GO:0048168)4.72585774
15synaptic vesicle exocytosis (GO:0016079)4.70358730
16protein localization to synapse (GO:0035418)4.68943236
17ionotropic glutamate receptor signaling pathway (GO:0035235)4.65038334
18prepulse inhibition (GO:0060134)4.64329649
19exploration behavior (GO:0035640)4.62421030
20proline biosynthetic process (GO:0006561)4.59337387
21regulation of synaptic vesicle exocytosis (GO:2000300)4.41820463
22ribosomal small subunit biogenesis (GO:0042274)4.39681426
23neuron-neuron synaptic transmission (GO:0007270)4.26307958
24dendritic spine morphogenesis (GO:0060997)4.24841203
25neurotransmitter-gated ion channel clustering (GO:0072578)4.24119771
26regulation of dendritic spine morphogenesis (GO:0061001)4.22200240
27behavioral response to cocaine (GO:0048148)4.18393261
28glutamate secretion (GO:0014047)4.17353558
29membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.16675834
30glutamate receptor signaling pathway (GO:0007215)4.15399111
31synaptic transmission, glutamatergic (GO:0035249)4.14027609
32synaptic vesicle docking involved in exocytosis (GO:0016081)4.13040872
33neuronal action potential propagation (GO:0019227)4.12898922
34neurotransmitter secretion (GO:0007269)4.11490798
35regulation of excitatory postsynaptic membrane potential (GO:0060079)4.07990715
36layer formation in cerebral cortex (GO:0021819)4.07833777
37adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)4.06212687
38long-term memory (GO:0007616)4.05575843
39striatum development (GO:0021756)3.98494149
40regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.98331810
41positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.96822795
42peptidyl-arginine omega-N-methylation (GO:0035247)3.96760944
43regulation of synaptic vesicle transport (GO:1902803)3.95974854
44positive regulation of synaptic transmission, GABAergic (GO:0032230)3.92619944
45neuron cell-cell adhesion (GO:0007158)3.89512916
46positive regulation of membrane potential (GO:0045838)3.84787737
47positive regulation of neurotransmitter transport (GO:0051590)3.83218667
48G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.81511430
49response to amphetamine (GO:0001975)3.81109218
50regulation of glutamate secretion (GO:0014048)3.80244842
51neuromuscular process controlling balance (GO:0050885)3.80148722
52proline metabolic process (GO:0006560)3.79496818
53regulation of postsynaptic membrane potential (GO:0060078)3.78436807
54regulation of synaptic plasticity (GO:0048167)3.77790377
55heterochromatin organization (GO:0070828)3.77464654
56auditory behavior (GO:0031223)3.77165749
57regulation of dopamine uptake involved in synaptic transmission (GO:0051584)3.72903742
58regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)3.72903742
59positive regulation of neurotransmitter secretion (GO:0001956)3.72593785
60positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.70096823
61behavioral fear response (GO:0001662)3.67603203
62behavioral defense response (GO:0002209)3.67603203
63dopamine receptor signaling pathway (GO:0007212)3.67483243
64L-serine metabolic process (GO:0006563)3.67190954
65response to histamine (GO:0034776)3.66580318
66regulation of female receptivity (GO:0045924)3.66305264
67activation of protein kinase A activity (GO:0034199)3.65080207
68transmission of nerve impulse (GO:0019226)3.64957705
69gamma-aminobutyric acid transport (GO:0015812)3.63608489
70long-term synaptic potentiation (GO:0060291)3.60508687
71histone arginine methylation (GO:0034969)3.59431534
72regulation of synaptic transmission, glutamatergic (GO:0051966)3.59202435
73positive regulation of synapse maturation (GO:0090129)3.53879649
74response to auditory stimulus (GO:0010996)3.51699783
75planar cell polarity pathway involved in neural tube closure (GO:0090179)3.50606072
76negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.47552682
77regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.47375064
78cellular potassium ion homeostasis (GO:0030007)3.44615861
79embryonic skeletal joint morphogenesis (GO:0060272)3.41654508
80regulation of dendritic spine development (GO:0060998)3.40680199
81regulation of neurotransmitter uptake (GO:0051580)3.40201685
82viral transcription (GO:0019083)3.40063884
83fear response (GO:0042596)3.39884852
84proline transport (GO:0015824)3.38063945
85adenosine receptor signaling pathway (GO:0001973)3.36933159
86learning (GO:0007612)3.32843269
87dendritic spine organization (GO:0097061)3.32508526
88neuronal ion channel clustering (GO:0045161)3.29633420
89apoptotic process involved in morphogenesis (GO:0060561)3.29337969
90neuron recognition (GO:0008038)3.29153210
91female mating behavior (GO:0060180)3.28308633
92neurotransmitter transport (GO:0006836)3.28133678
93positive regulation of dendritic spine development (GO:0060999)3.25651272
94negative regulation of dendrite development (GO:2000171)3.22290550
95peptidyl-arginine methylation (GO:0018216)3.22046373
96peptidyl-arginine N-methylation (GO:0035246)3.22046373
97maternal placenta development (GO:0001893)3.21871101
98positive regulation of dendritic spine morphogenesis (GO:0061003)3.21131593
99membrane depolarization (GO:0051899)3.20026361
100negative regulation of cytosolic calcium ion concentration (GO:0051481)3.19553949
101regulation of vesicle fusion (GO:0031338)3.19327101
102regulation of voltage-gated calcium channel activity (GO:1901385)3.19295966
103translational termination (GO:0006415)3.18115090
104mating behavior (GO:0007617)3.16560511
105regulation of neurotransmitter levels (GO:0001505)3.14669008
106regulation of neurotransmitter secretion (GO:0046928)3.14161037
107regulation of neurotransmitter transport (GO:0051588)3.13559238
108maturation of SSU-rRNA (GO:0030490)3.11773744
109gamma-aminobutyric acid signaling pathway (GO:0007214)3.11475395
110synaptic vesicle endocytosis (GO:0048488)3.11029029
111visual learning (GO:0008542)3.11014110
112outflow tract septum morphogenesis (GO:0003148)3.10697664
113positive regulation of synaptic transmission (GO:0050806)3.10265274
114membrane hyperpolarization (GO:0060081)3.09366100
115protein complex localization (GO:0031503)3.09265191
116vesicle transport along microtubule (GO:0047496)3.08094864
117sodium ion export (GO:0071436)3.07776613
118regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.07746713
119glycine transport (GO:0015816)3.06098168
120regulation of translational fidelity (GO:0006450)3.04731855
121convergent extension (GO:0060026)3.03946859
122negative regulation of amino acid transport (GO:0051956)3.03700280
123regulation of synaptic transmission, GABAergic (GO:0032228)3.01786448
124translational elongation (GO:0006414)2.87591085
125adherens junction assembly (GO:0034333)2.87009420
126nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.84271089
127rRNA transcription (GO:0009303)2.83912010
128ribosomal small subunit assembly (GO:0000028)2.80977297
129mitotic chromosome condensation (GO:0007076)2.79638202
130protein retention in ER lumen (GO:0006621)2.79600319
131RNA localization (GO:0006403)2.78664548
132cochlea morphogenesis (GO:0090103)2.75954381
133cell-cell junction maintenance (GO:0045217)2.75460453
134mitotic G1 DNA damage checkpoint (GO:0031571)2.71422991
135regulation of mitochondrial translation (GO:0070129)2.71088615
136gap junction assembly (GO:0016264)2.69925683
137cellular protein complex localization (GO:0034629)2.69056970
138serine family amino acid biosynthetic process (GO:0009070)2.68526585
139DNA unwinding involved in DNA replication (GO:0006268)2.67669051
140negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.66845977
141protein maturation by protein folding (GO:0022417)2.61488092
142muscle cell fate commitment (GO:0042693)2.61134265
143SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.60472634
144cell-substrate adherens junction assembly (GO:0007045)2.60449338
145focal adhesion assembly (GO:0048041)2.60449338
146spliceosomal tri-snRNP complex assembly (GO:0000244)2.56969056
147maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.53578600
148viral mRNA export from host cell nucleus (GO:0046784)2.53294611
149cotranslational protein targeting to membrane (GO:0006613)2.52844605
150protein targeting to ER (GO:0045047)2.52467748
151viral life cycle (GO:0019058)2.52458620
152lung epithelium development (GO:0060428)2.51462232
153negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.51411836
154establishment of apical/basal cell polarity (GO:0035089)2.50345489
155ribonucleoprotein complex biogenesis (GO:0022613)2.49071710
156GDP-mannose metabolic process (GO:0019673)2.48433455
157formation of translation preinitiation complex (GO:0001731)2.46238941
158negative regulation of cell fate specification (GO:0009996)2.45526992
159paraxial mesoderm development (GO:0048339)2.45371553
160embryonic eye morphogenesis (GO:0048048)2.45363965
161mammary gland epithelial cell differentiation (GO:0060644)2.44734348
162tooth mineralization (GO:0034505)2.44655184
163regulation of cardioblast differentiation (GO:0051890)2.44460544
164erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.43869826
165L-phenylalanine metabolic process (GO:0006558)2.43869826
166DNA replication checkpoint (GO:0000076)2.43736848
167G1 DNA damage checkpoint (GO:0044783)2.42155198
168cellular protein complex disassembly (GO:0043624)2.41210508
169regulation of cholesterol biosynthetic process (GO:0045540)2.39255485
170establishment of protein localization to endoplasmic reticulum (GO:0072599)2.38382289
171Golgi transport vesicle coating (GO:0048200)2.38030164
172COPI coating of Golgi vesicle (GO:0048205)2.38030164
173pentose metabolic process (GO:0019321)2.38000969
174outer ear morphogenesis (GO:0042473)2.37952451
175negative regulation of cell size (GO:0045792)2.37946850
176translational initiation (GO:0006413)2.37940595
177regulation of hair follicle development (GO:0051797)2.37855372
178regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901212.37377292
179protein complex disassembly (GO:0043241)2.37341031
1804-hydroxyproline metabolic process (GO:0019471)2.36917980
181apoptotic process involved in development (GO:1902742)2.36333177
182cell migration in hindbrain (GO:0021535)2.35593952
183negative regulation of striated muscle cell apoptotic process (GO:0010664)2.35588290
184chromatin assembly (GO:0031497)2.35310901
185protein-DNA complex disassembly (GO:0032986)2.34942605
186nucleosome disassembly (GO:0006337)2.34942605
187vagina development (GO:0060068)2.34242666
188protein localization to endoplasmic reticulum (GO:0070972)2.34088869
189basement membrane organization (GO:0071711)2.33732435
190epithelial cell-cell adhesion (GO:0090136)2.33523138
191protein carboxylation (GO:0018214)2.33423330
192peptidyl-glutamic acid carboxylation (GO:0017187)2.33423330
193Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.32846843
194body morphogenesis (GO:0010171)2.32686683
195dorsal/ventral neural tube patterning (GO:0021904)2.32325969
196branching involved in mammary gland duct morphogenesis (GO:0060444)2.27098466
197positive regulation of hormone metabolic process (GO:0032352)2.26949173
198regulation of stem cell maintenance (GO:2000036)2.26293963
199regulation of fatty acid beta-oxidation (GO:0031998)2.25410875
200mitotic G1/S transition checkpoint (GO:0044819)2.25328050

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.39702047
2RARB_27405468_Chip-Seq_BRAIN_Mouse3.38702499
3* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.30916765
4* JARID2_20064375_ChIP-Seq_MESCs_Mouse3.30212736
5* SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.28645417
6GBX2_23144817_ChIP-Seq_PC3_Human3.23139587
7TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.22741141
8MYC_18555785_ChIP-Seq_MESCs_Mouse3.00597043
9E2F7_22180533_ChIP-Seq_HELA_Human2.94501984
10HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.91866852
11* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.90164363
12* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.90164363
13* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.87121418
14* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.80103986
15* REST_21632747_ChIP-Seq_MESCs_Mouse2.78441069
16* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.71037755
17* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.66889161
18EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.66401095
19* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.65422626
20ZNF263_19887448_ChIP-Seq_K562_Human2.64948422
21SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.59246424
22DROSHA_22980978_ChIP-Seq_HELA_Human2.54352617
23* EZH2_27304074_Chip-Seq_ESCs_Mouse2.53838291
24IKZF1_21737484_ChIP-ChIP_HCT116_Human2.46998101
25MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.44237363
26SUZ12_27294783_Chip-Seq_ESCs_Mouse2.40507473
27EZH2_27294783_Chip-Seq_ESCs_Mouse2.38246325
28ESR1_15608294_ChIP-ChIP_MCF-7_Human2.33185969
29* REST_18959480_ChIP-ChIP_MESCs_Mouse2.30938169
30RNF2_27304074_Chip-Seq_ESCs_Mouse2.30038975
31FOXM1_23109430_ChIP-Seq_U2OS_Human2.29799354
32EED_16625203_ChIP-ChIP_MESCs_Mouse2.28681257
33TP63_17297297_ChIP-ChIP_HaCaT_Human2.22524863
34MYC_19079543_ChIP-ChIP_MESCs_Mouse2.18862337
35MYC_18358816_ChIP-ChIP_MESCs_Mouse2.15970587
36EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.12564660
37RACK7_27058665_Chip-Seq_MCF-7_Human2.12186594
38XRN2_22483619_ChIP-Seq_HELA_Human2.12183757
39ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.04604308
40MYC_19030024_ChIP-ChIP_MESCs_Mouse1.95844606
41LXR_22292898_ChIP-Seq_THP-1_Human1.95211017
42AR_21572438_ChIP-Seq_LNCaP_Human1.93795259
43MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.91893016
44ERG_21242973_ChIP-ChIP_JURKAT_Human1.87707186
45TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.86696594
46DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.85503348
47FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.84924941
48PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.84269377
49ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.83956820
50CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.80023317
51ESR2_21235772_ChIP-Seq_MCF-7_Human1.77862594
52NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.77350887
53ZFX_18555785_ChIP-Seq_MESCs_Mouse1.76359914
54CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.74806777
55THAP11_20581084_ChIP-Seq_MESCs_Mouse1.73098689
56THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.68448521
57ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.66758635
58MYC_22102868_ChIP-Seq_BL_Human1.65679524
59TET1_21451524_ChIP-Seq_MESCs_Mouse1.64479117
60RARG_19884340_ChIP-ChIP_MEFs_Mouse1.64262041
61CTBP2_25329375_ChIP-Seq_LNCAP_Human1.62303223
62POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.61863069
63JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.60965400
64ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.59431516
65KLF4_18555785_ChIP-Seq_MESCs_Mouse1.58055422
66NELFA_20434984_ChIP-Seq_ESCs_Mouse1.54506759
67TAF15_26573619_Chip-Seq_HEK293_Human1.53297748
68SMAD4_21799915_ChIP-Seq_A2780_Human1.52378578
69SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.51697580
70CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.51679320
71CTBP1_25329375_ChIP-Seq_LNCAP_Human1.49322456
72KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.47706225
73POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.47335788
74SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.47198160
75ELK3_25401928_ChIP-Seq_HUVEC_Human1.45052153
76DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.42637443
77KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.41324018
78KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.39733550
79ESR1_21235772_ChIP-Seq_MCF-7_Human1.39450699
80* RING1B_27294783_Chip-Seq_ESCs_Mouse1.37626654
81PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.37092064
82VDR_21846776_ChIP-Seq_THP-1_Human1.36776448
83DNAJC2_21179169_ChIP-ChIP_NT2_Human1.35236163
84P68_20966046_ChIP-Seq_HELA_Human1.34386200
85* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.34239386
86NR3C1_23031785_ChIP-Seq_PC12_Mouse1.33942094
87E2F1_18555785_ChIP-Seq_MESCs_Mouse1.33181418
88GABP_19822575_ChIP-Seq_HepG2_Human1.33156716
89NANOG_18555785_ChIP-Seq_MESCs_Mouse1.32795842
90GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.32399548
91* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.32359375
92AR_21909140_ChIP-Seq_LNCAP_Human1.30701162
93DCP1A_22483619_ChIP-Seq_HELA_Human1.30365611
94GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.29261182
95TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.28940003
96WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.28664503
97SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.28123672
98HIF1A_21447827_ChIP-Seq_MCF-7_Human1.27487799
99* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.26962616
100ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.26540631
101* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.25497103
102KDM2B_26808549_Chip-Seq_K562_Human1.25146752
103CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.25061142
104MYCN_18555785_ChIP-Seq_MESCs_Mouse1.24746464
105ZNF274_21170338_ChIP-Seq_K562_Hela1.24739155
106TTF2_22483619_ChIP-Seq_HELA_Human1.24338359
107SOX2_21211035_ChIP-Seq_LN229_Gbm1.23902342
108* SMAD3_21741376_ChIP-Seq_EPCs_Human1.22939272
109STAT3_1855785_ChIP-Seq_MESCs_Mouse1.22340509
110STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.21025518
111RING1B_27294783_Chip-Seq_NPCs_Mouse1.20966895
112E2F1_21310950_ChIP-Seq_MCF-7_Human1.20210966
113TP53_20018659_ChIP-ChIP_R1E_Mouse1.19742437
114* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.19028347
115* P300_19829295_ChIP-Seq_ESCs_Human1.18896909
116RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.18807031
117NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.18674228
118CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.18484744
119SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.18375818
120ZFP281_18757296_ChIP-ChIP_E14_Mouse1.17880559
121* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.16713814
122* AR_19668381_ChIP-Seq_PC3_Human1.16652712
123CREB1_26743006_Chip-Seq_LNCaP_Human1.16197772
124SRY_22984422_ChIP-ChIP_TESTIS_Rat1.15972798
125KDM5A_27292631_Chip-Seq_BREAST_Human1.15779593
126ETS1_20019798_ChIP-Seq_JURKAT_Human1.15338311
127KDM2B_26808549_Chip-Seq_SUP-B15_Human1.14903021
128FOXP1_21924763_ChIP-Seq_HESCs_Human1.14862783
129SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.14176212
130UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.14051194
131AR_25329375_ChIP-Seq_VCAP_Human1.13845245
132P53_22127205_ChIP-Seq_FIBROBLAST_Human1.13038550
133TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.12866885
134* RUNX1_27514584_Chip-Seq_MCF-7_Human1.12543231
135ZFP57_27257070_Chip-Seq_ESCs_Mouse1.12050298
136ATF3_27146783_Chip-Seq_COLON_Human1.11820931
137CTCF_18555785_ChIP-Seq_MESCs_Mouse1.11571051
138SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.11519964
139NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.11227319
140TOP2B_26459242_ChIP-Seq_MCF-7_Human1.11187877
141STAT3_23295773_ChIP-Seq_U87_Human1.10877926
142GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.10367136
143TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.08151355
144SA1_27219007_Chip-Seq_ERYTHROID_Human1.06707490
145KDM2B_26808549_Chip-Seq_DND41_Human1.04396829
146PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.04292932
147SMC4_20622854_ChIP-Seq_HELA_Human1.04253745
148* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.03823024
149TCF7_22412390_ChIP-Seq_EML_Mouse1.03766779
150CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.03307207
151OCT4_18692474_ChIP-Seq_MEFs_Mouse1.03277357
152BMI1_23680149_ChIP-Seq_NPCS_Mouse1.03013298
153CBX2_27304074_Chip-Seq_ESCs_Mouse1.01494790
154* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.01434947
155KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.01193696
156KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.01166499
157KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.01166499
158KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.01166499
159MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.01041811
160OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.00977609
161YY1_21170310_ChIP-Seq_MESCs_Mouse1.00268140
162MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.00060519
163CDX2_19796622_ChIP-Seq_MESCs_Mouse0.99801126
164SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.99005582
165CREB1_15753290_ChIP-ChIP_HEK293T_Human0.97536781
166* CTCF_27219007_Chip-Seq_Bcells_Human0.96838903
167TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.96752017
168TCF4_23295773_ChIP-Seq_U87_Human0.96653854
169PRDM14_20953172_ChIP-Seq_ESCs_Human0.96548538
170YAP1_20516196_ChIP-Seq_MESCs_Mouse0.96196860
171* SMAD3_21741376_ChIP-Seq_HESCs_Human0.95970960
172AHR_22903824_ChIP-Seq_MCF-7_Human0.94404049
173TP53_16413492_ChIP-PET_HCT116_Human0.94320329
174RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.94155589
175* TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.93635201
176VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.92498808
177PIAS1_25552417_ChIP-Seq_VCAP_Human0.92179477
178CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.92006377
179* SMAD3_21741376_ChIP-Seq_ESCs_Human0.91024790
180* SMAD4_21741376_ChIP-Seq_HESCs_Human0.90751002
181UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.90007322
182SMAD_19615063_ChIP-ChIP_OVARY_Human0.89807767
183ARNT_22903824_ChIP-Seq_MCF-7_Human0.89752451
184* RUNX2_22187159_ChIP-Seq_PCA_Human0.88033232
185ZFP281_27345836_Chip-Seq_ESCs_Mouse0.86958556
186BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.86410643
187RXR_22108803_ChIP-Seq_LS180_Human0.86004038
188NR3C1_21868756_ChIP-Seq_MCF10A_Human0.85746917
189AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.84415349
190RNF2_27304074_Chip-Seq_NSC_Mouse0.84269981
191TET1_21490601_ChIP-Seq_MESCs_Mouse0.83985855
192JUN_21703547_ChIP-Seq_K562_Human0.81805304

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.82933067
2MP0002822_catalepsy5.82779995
3MP0003880_abnormal_central_pattern4.84269996
4MP0003635_abnormal_synaptic_transmissio4.30715423
5MP0009745_abnormal_behavioral_response3.76620024
6MP0004270_analgesia3.71899110
7* MP0002063_abnormal_learning/memory/cond3.58239280
8MP0010030_abnormal_orbit_morphology3.14181824
9MP0002064_seizures3.09600433
10MP0003705_abnormal_hypodermis_morpholog3.09011704
11MP0003123_paternal_imprinting3.03357641
12MP0002249_abnormal_larynx_morphology3.01221703
13MP0001968_abnormal_touch/_nociception2.91089089
14* MP0002572_abnormal_emotion/affect_behav2.86288750
15MP0009046_muscle_twitch2.76243689
16MP0000566_synostosis2.66840110
17MP0002272_abnormal_nervous_system2.60693915
18* MP0001486_abnormal_startle_reflex2.51492386
19MP0002734_abnormal_mechanical_nocicepti2.41314084
20MP0002736_abnormal_nociception_after2.32456892
21MP0005076_abnormal_cell_differentiation2.29560337
22MP0005423_abnormal_somatic_nervous2.29327782
23MP0003693_abnormal_embryo_hatching2.26767196
24MP0001501_abnormal_sleep_pattern2.26365983
25MP0001529_abnormal_vocalization2.17693992
26MP0002735_abnormal_chemical_nociception2.13497146
27MP0003942_abnormal_urinary_system2.13086214
28MP0002909_abnormal_adrenal_gland2.10063708
29MP0001440_abnormal_grooming_behavior2.09709374
30MP0001346_abnormal_lacrimal_gland2.09165992
31MP0004185_abnormal_adipocyte_glucose2.06744843
32MP0000678_abnormal_parathyroid_gland1.98892447
33MP0002733_abnormal_thermal_nociception1.97312911
34MP0001970_abnormal_pain_threshold1.97163396
35MP0003111_abnormal_nucleus_morphology1.94075455
36MP0002089_abnormal_postnatal_growth/wei1.92634921
37MP0004957_abnormal_blastocyst_morpholog1.91098058
38MP0005386_behavior/neurological_phenoty1.81916536
39MP0004924_abnormal_behavior1.81916536
40MP0002697_abnormal_eye_size1.78869549
41MP0008569_lethality_at_weaning1.78294492
42MP0004811_abnormal_neuron_physiology1.75659169
43MP0002067_abnormal_sensory_capabilities1.75042212
44MP0003329_amyloid_beta_deposits1.74802088
45MP0004264_abnormal_extraembryonic_tissu1.73644295
46MP0002796_impaired_skin_barrier1.69813037
47MP0002557_abnormal_social/conspecific_i1.69743120
48MP0009672_abnormal_birth_weight1.68843557
49MP0008932_abnormal_embryonic_tissue1.68312609
50MP0002184_abnormal_innervation1.67465970
51MP0009780_abnormal_chondrocyte_physiolo1.67082704
52MP0001984_abnormal_olfaction1.66954886
53MP0004858_abnormal_nervous_system1.66553043
54MP0000537_abnormal_urethra_morphology1.65971648
55MP0005646_abnormal_pituitary_gland1.63152744
56MP0000049_abnormal_middle_ear1.59658973
57MP0003879_abnormal_hair_cell1.52708754
58MP0003077_abnormal_cell_cycle1.51301395
59MP0000778_abnormal_nervous_system1.50301532
60MP0005501_abnormal_skin_physiology1.49478350
61MP0001730_embryonic_growth_arrest1.48922797
62MP0006276_abnormal_autonomic_nervous1.47636838
63MP0000534_abnormal_ureter_morphology1.47294752
64MP0002234_abnormal_pharynx_morphology1.46179885
65MP0005409_darkened_coat_color1.45552481
66MP0003937_abnormal_limbs/digits/tail_de1.45451059
67MP0000955_abnormal_spinal_cord1.44975868
68MP0003315_abnormal_perineum_morphology1.44309061
69MP0004885_abnormal_endolymph1.44288752
70MP0002098_abnormal_vibrissa_morphology1.42268836
71MP0001905_abnormal_dopamine_level1.39547294
72MP0001188_hyperpigmentation1.38313036
73MP0002160_abnormal_reproductive_system1.38103712
74MP0002066_abnormal_motor_capabilities/c1.37818438
75MP0003941_abnormal_skin_development1.37248109
76MP0005257_abnormal_intraocular_pressure1.36534589
77MP0009379_abnormal_foot_pigmentation1.36394792
78MP0003633_abnormal_nervous_system1.34724534
79MP0009384_cardiac_valve_regurgitation1.32392668
80MP0005670_abnormal_white_adipose1.31155186
81MP0002085_abnormal_embryonic_tissue1.30095924
82MP0002882_abnormal_neuron_morphology1.30084261
83MP0002092_abnormal_eye_morphology1.29713414
84MP0001293_anophthalmia1.28480926
85MP0005380_embryogenesis_phenotype1.27384852
86MP0001672_abnormal_embryogenesis/_devel1.27384852
87MP0002111_abnormal_tail_morphology1.20482910
88MP0000462_abnormal_digestive_system1.19405792
89MP0008872_abnormal_physiological_respon1.19158644
90MP0000003_abnormal_adipose_tissue1.18773165
91MP0001697_abnormal_embryo_size1.18605850
92MP0003075_altered_response_to1.18492254
93MP0002932_abnormal_joint_morphology1.18345252
94MP0005666_abnormal_adipose_tissue1.17722443
95MP0009053_abnormal_anal_canal1.16528712
96MP0008874_decreased_physiological_sensi1.16252033
97MP0005451_abnormal_body_composition1.16142135
98MP0001849_ear_inflammation1.15547760
99MP0000350_abnormal_cell_proliferation1.12281023
100MP0010094_abnormal_chromosome_stability1.11805713
101MP0003115_abnormal_respiratory_system1.11455073
102MP0005377_hearing/vestibular/ear_phenot1.10766822
103MP0003878_abnormal_ear_physiology1.10766822
104MP0006292_abnormal_olfactory_placode1.10227458
105MP0003631_nervous_system_phenotype1.10156573
106MP0002080_prenatal_lethality1.09536058
107MP0003984_embryonic_growth_retardation1.09194217
108MP0009250_abnormal_appendicular_skeleto1.07050323
109MP0001348_abnormal_lacrimal_gland1.07005213
110MP0002088_abnormal_embryonic_growth/wei1.06882222
111MP0000762_abnormal_tongue_morphology1.06673043
112MP0005167_abnormal_blood-brain_barrier1.05626594
113MP0002116_abnormal_craniofacial_bone1.05410040
114MP0001502_abnormal_circadian_rhythm1.05351799
115MP0001286_abnormal_eye_development1.04755787
116MP0005375_adipose_tissue_phenotype1.04253882
117MP0002938_white_spotting1.03410708
118MP0005058_abnormal_lysosome_morphology1.02705242
119MP0002163_abnormal_gland_morphology1.01557718
120MP0002152_abnormal_brain_morphology1.00605446
121MP0001177_atelectasis0.99109034
122MP0000013_abnormal_adipose_tissue0.98600949
123MP0002084_abnormal_developmental_patter0.98358341
124MP0004272_abnormal_basement_membrane0.97864975
125MP0000733_abnormal_muscle_development0.97557513
126MP0003385_abnormal_body_wall0.97182638
127MP0002069_abnormal_eating/drinking_beha0.96882466
128MP0005535_abnormal_body_temperature0.96684525
129MP0004085_abnormal_heartbeat0.95147016
130MP0004142_abnormal_muscle_tone0.94540320
131MP0010234_abnormal_vibrissa_follicle0.94405137
132MP0003567_abnormal_fetal_cardiomyocyte0.94217827
133MP0001340_abnormal_eyelid_morphology0.93955849
134MP0010630_abnormal_cardiac_muscle0.93925085
135MP0003935_abnormal_craniofacial_develop0.92578339
136MP0003283_abnormal_digestive_organ0.92549411
137MP0002086_abnormal_extraembryonic_tissu0.91446964
138MP0005645_abnormal_hypothalamus_physiol0.91043213
139MP0000751_myopathy0.90518632
140MP0005408_hypopigmentation0.90116402
141MP0002114_abnormal_axial_skeleton0.89965256
142MP0003787_abnormal_imprinting0.89638292
143MP0000428_abnormal_craniofacial_morphol0.89322244
144MP0008260_abnormal_autophagy0.88988862
145MP0005394_taste/olfaction_phenotype0.88377518
146MP0005499_abnormal_olfactory_system0.88377518
147MP0000579_abnormal_nail_morphology0.87425735
148MP0002229_neurodegeneration0.85889350
149MP0008961_abnormal_basal_metabolism0.85778875
150MP0002233_abnormal_nose_morphology0.82449541
151MP0002877_abnormal_melanocyte_morpholog0.82347885
152MP0010386_abnormal_urinary_bladder0.81115925
153MP0003938_abnormal_ear_development0.81097858
154MP0003755_abnormal_palate_morphology0.80337077
155MP0000604_amyloidosis0.80165395
156MP0000627_abnormal_mammary_gland0.79768464
157MP0003566_abnormal_cell_adhesion0.78408219
158MP0001661_extended_life_span0.77715770
159MP0004197_abnormal_fetal_growth/weight/0.77660931
160MP0003634_abnormal_glial_cell0.77449147
161MP0002090_abnormal_vision0.76385112
162MP0000920_abnormal_myelination0.75536689
163MP0008007_abnormal_cellular_replicative0.74467541
164MP0003690_abnormal_glial_cell0.74215270
165MP0002837_dystrophic_cardiac_calcinosis0.71723767
166MP0005187_abnormal_penis_morphology0.70322126
167MP0005551_abnormal_eye_electrophysiolog0.69403036
168MP0003137_abnormal_impulse_conducting0.68311313
169MP0003632_abnormal_nervous_system0.68264876
170MP0004145_abnormal_muscle_electrophysio0.65713349
171MP0001963_abnormal_hearing_physiology0.63637929
172MP0004742_abnormal_vestibular_system0.63554645
173MP0001664_abnormal_digestion0.62682657
174MP0002752_abnormal_somatic_nervous0.62431425
175MP0000631_abnormal_neuroendocrine_gland0.60587511
176MP0004484_altered_response_of0.59469376
177MP0003122_maternal_imprinting0.58918683
178MP0005623_abnormal_meninges_morphology0.58314723
179MP0001485_abnormal_pinna_reflex0.57506124
180MP0005166_decreased_susceptibility_to0.53743454
181MP0000569_abnormal_digit_pigmentation0.52221398
182MP0004215_abnormal_myocardial_fiber0.50299431
183MP0001943_abnormal_respiration0.48856489
184MP0003956_abnormal_body_size0.47545995
185MP0004510_myositis0.46251463
186MP0004233_abnormal_muscle_weight0.45660554
187MP0002638_abnormal_pupillary_reflex0.45321817
188MP0005620_abnormal_muscle_contractility0.43869692
189MP0010769_abnormal_survival0.43626219
190MP0003861_abnormal_nervous_system0.43136870

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)8.86766713
2Focal motor seizures (HP:0011153)7.82595115
3Focal seizures (HP:0007359)5.69671080
4Visual hallucinations (HP:0002367)5.43463658
5Action tremor (HP:0002345)4.35364660
6Epileptic encephalopathy (HP:0200134)4.17687230
7Febrile seizures (HP:0002373)4.17446054
8Atonic seizures (HP:0010819)4.14042437
9Absence seizures (HP:0002121)3.99150956
10Septate vagina (HP:0001153)3.98380398
11Deep venous thrombosis (HP:0002625)3.97955203
12Generalized tonic-clonic seizures (HP:0002069)3.77723761
13Anxiety (HP:0000739)3.65629210
14Dialeptic seizures (HP:0011146)3.63928567
15Poor eye contact (HP:0000817)3.62811806
16Asymmetry of the thorax (HP:0001555)3.62623987
17Progressive cerebellar ataxia (HP:0002073)3.62220110
18Annular pancreas (HP:0001734)3.58552342
19Impaired vibration sensation in the lower limbs (HP:0002166)3.57833711
20Broad-based gait (HP:0002136)3.57604602
21Aplasia/Hypoplasia of the sacrum (HP:0008517)3.51930206
22Depression (HP:0000716)3.51188460
23Amblyopia (HP:0000646)3.49284204
24Supranuclear gaze palsy (HP:0000605)3.48511269
25Ankle clonus (HP:0011448)3.39650040
26Torticollis (HP:0000473)3.35954510
27Impaired social interactions (HP:0000735)3.30129306
28Abnormal social behavior (HP:0012433)3.30129306
29Abnormal ventriculo-arterial connection (HP:0011563)3.30058102
30Transposition of the great arteries (HP:0001669)3.30058102
31Abnormal connection of the cardiac segments (HP:0011545)3.30058102
32Dysdiadochokinesis (HP:0002075)3.29772894
33Urinary bladder sphincter dysfunction (HP:0002839)3.27443572
34Resting tremor (HP:0002322)3.25724112
35Gaze-evoked nystagmus (HP:0000640)3.22831193
36Dysmetria (HP:0001310)3.12889427
37Hyperventilation (HP:0002883)3.11376355
38Truncal ataxia (HP:0002078)3.04856221
39Focal dystonia (HP:0004373)3.02227441
40Cerebral inclusion bodies (HP:0100314)2.99156825
41Urinary urgency (HP:0000012)2.97792511
42Abnormality of the aortic arch (HP:0012303)2.95145375
43Postural instability (HP:0002172)2.94870097
44Hyperacusis (HP:0010780)2.94668602
45Broad distal phalanx of finger (HP:0009836)2.89182734
46Craniofacial dystonia (HP:0012179)2.83584730
47Ulnar bowing (HP:0003031)2.80000355
48Scanning speech (HP:0002168)2.74235362
49Stereotypic behavior (HP:0000733)2.74183183
50Papilledema (HP:0001085)2.73504725
51Abnormality of the lower motor neuron (HP:0002366)2.71543320
52Impaired smooth pursuit (HP:0007772)2.70028608
53Mutism (HP:0002300)2.65230989
54Nuclear cataract (HP:0100018)2.65169538
55Abnormal eating behavior (HP:0100738)2.64213528
56Insidious onset (HP:0003587)2.60927291
57Termporal pattern (HP:0011008)2.60927291
58Neurofibrillary tangles (HP:0002185)2.56900845
59Megalencephaly (HP:0001355)2.55718714
60Spastic gait (HP:0002064)2.55541318
61Dysmetric saccades (HP:0000641)2.54889236
62Intention tremor (HP:0002080)2.54640090
63Renal duplication (HP:0000075)2.54481222
64Bradykinesia (HP:0002067)2.54277132
65Abnormality of the umbilical cord (HP:0010881)2.53900006
66Single umbilical artery (HP:0001195)2.52023536
67Abnormality of the fetal cardiovascular system (HP:0010948)2.52023536
68Abnormal umbilical cord blood vessels (HP:0011403)2.52023536
69Ankyloglossia (HP:0010296)2.50224482
70Pointed chin (HP:0000307)2.49688997
71Congenital malformation of the right heart (HP:0011723)2.49323879
72Double outlet right ventricle (HP:0001719)2.49323879
73Vaginal fistula (HP:0004320)2.46515287
74Abnormality of the phalanges of the hallux (HP:0010057)2.45758483
75Progressive inability to walk (HP:0002505)2.45600378
76Ventricular fibrillation (HP:0001663)2.44878340
77Drooling (HP:0002307)2.43253030
78Excessive salivation (HP:0003781)2.43253030
79Impaired vibratory sensation (HP:0002495)2.41605932
80Partial duplication of the phalanx of hand (HP:0009999)2.39480908
81Hemiparesis (HP:0001269)2.37045129
82Lower limb amyotrophy (HP:0007210)2.33883606
83Delusions (HP:0000746)2.32690016
84Abnormality of carpal bone ossification (HP:0006257)2.32453700
85Epileptiform EEG discharges (HP:0011182)2.31564416
86Partial duplication of thumb phalanx (HP:0009944)2.29790885
87Lower limb asymmetry (HP:0100559)2.26000019
88Abnormality of ocular smooth pursuit (HP:0000617)2.23341477
89Abnormality of binocular vision (HP:0011514)2.21671232
90Diplopia (HP:0000651)2.21671232
91Abnormal EKG (HP:0003115)2.20180088
92EEG with generalized epileptiform discharges (HP:0011198)2.17931466
93Incomplete penetrance (HP:0003829)2.17585184
94Lower limb muscle weakness (HP:0007340)2.17532080
95Periauricular skin pits (HP:0100277)2.16846298
96Preauricular pit (HP:0004467)2.16846298
97Prolonged QT interval (HP:0001657)2.16320209
98Progressive muscle weakness (HP:0003323)2.14955319
99Fetal akinesia sequence (HP:0001989)2.11683408
100Genetic anticipation (HP:0003743)2.10244484
101Hemiplegia (HP:0002301)2.09423072
102Atresia of the external auditory canal (HP:0000413)2.07281882
103Status epilepticus (HP:0002133)2.06872661
104Hypsarrhythmia (HP:0002521)2.06702794
105Abnormality of cells of the erythroid lineage (HP:0012130)2.05852051
106Abnormality of the corticospinal tract (HP:0002492)2.05697603
107Abnormal ossification of hand bones (HP:0005921)2.02643408
108Stridor (HP:0010307)2.01698361
109Prolonged partial thromboplastin time (HP:0003645)2.00769617
110Insomnia (HP:0100785)2.00012103
111Rapidly progressive (HP:0003678)1.99860102
112Bicornuate uterus (HP:0000813)1.99401265
113Obstructive sleep apnea (HP:0002870)1.98985546
114Absent speech (HP:0001344)1.98688801
115Abnormality of the distal phalanges of the toes (HP:0010182)1.97450945
116Reticulocytopenia (HP:0001896)1.97022285
117J-shaped sella turcica (HP:0002680)1.96872458
118Small epiphyses (HP:0010585)1.96303736
119Birth length less than 3rd percentile (HP:0003561)1.95950362
120Duplication of thumb phalanx (HP:0009942)1.95610771
121Limb dystonia (HP:0002451)1.95468229
122Microglossia (HP:0000171)1.95090134
123Abnormality of the distal phalanx of the thumb (HP:0009617)1.94857301
124Hypoplastic left heart (HP:0004383)1.94428695
125Zonular cataract (HP:0010920)1.93729986
126Long palpebral fissure (HP:0000637)1.93235473
127Spinal cord compression (HP:0002176)1.93079601
128Selective tooth agenesis (HP:0001592)1.91151942
129Hyperthyroidism (HP:0000836)1.90528421
130Pheochromocytoma (HP:0002666)1.90482832
131Overriding aorta (HP:0002623)1.90426937
132Abnormal tarsal ossification (HP:0008369)1.89669205
133Gait ataxia (HP:0002066)1.89002152
134Bundle branch block (HP:0011710)1.88850182
135Inability to walk (HP:0002540)1.88075070
136Apathy (HP:0000741)1.88037511
137Deep palmar crease (HP:0006191)1.87869980
138Abnormality of the Achilles tendon (HP:0005109)1.87687066
139Generalized myoclonic seizures (HP:0002123)1.87553467
140Flat acetabular roof (HP:0003180)1.86894613
141Increased nuchal translucency (HP:0010880)1.85941513
142Arnold-Chiari malformation (HP:0002308)1.85376290
143Bifid scrotum (HP:0000048)1.84591082
144Breast hypoplasia (HP:0003187)1.84242382
145Premature skin wrinkling (HP:0100678)1.83920282
146Hypercholesterolemia (HP:0003124)1.83846427
147Neoplasm of the peripheral nervous system (HP:0100007)1.83819433
148Clonus (HP:0002169)1.83751807
149Achilles tendon contracture (HP:0001771)1.83350072
150Abnormality of oral frenula (HP:0000190)1.83089828
151Neuronal loss in central nervous system (HP:0002529)1.81968838
152Micronodular cirrhosis (HP:0001413)1.81839205
153Concave nail (HP:0001598)1.81273804
154Hypoparathyroidism (HP:0000829)1.80775292
155Renal dysplasia (HP:0000110)1.80661671
156Psychosis (HP:0000709)1.80659075
157Lymphangioma (HP:0100764)1.80519331
158Tracheal stenosis (HP:0002777)1.80485183
159Rigidity (HP:0002063)1.80005195
160Rectovaginal fistula (HP:0000143)1.79886183
161Rectal fistula (HP:0100590)1.79886183
162Intestinal fistula (HP:0100819)1.79165850
163Abnormality of aromatic amino acid family metabolism (HP:0004338)1.79097209
164Germ cell neoplasia (HP:0100728)1.77683023
165Facial cleft (HP:0002006)1.77553544
166Elfin facies (HP:0004428)1.76956448
167Rectal prolapse (HP:0002035)1.76886655
168Abnormality of the lacrimal duct (HP:0011481)1.76706491
169Hypoplasia of the capital femoral epiphysis (HP:0003090)1.76006198
170Truncus arteriosus (HP:0001660)1.73906524
171Macrocytic anemia (HP:0001972)1.73870285
172Microretrognathia (HP:0000308)1.73138890
173Unilateral renal agenesis (HP:0000122)1.71629877
174Diastasis recti (HP:0001540)1.71354611
175Pterygium (HP:0001059)1.70934108
176Back pain (HP:0003418)1.70536129
177Blue irides (HP:0000635)1.70245940
178Abnormal hand bone ossification (HP:0010660)1.69420534
179Abnormality of saccadic eye movements (HP:0000570)1.69250574
180Embryonal neoplasm (HP:0002898)1.68806017
181Testicular atrophy (HP:0000029)1.68520355
182Biconcave vertebral bodies (HP:0004586)1.68379944
183Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.68194481
184Absent epiphyses (HP:0010577)1.68194481
185Protrusio acetabuli (HP:0003179)1.67715620
186Preauricular skin tag (HP:0000384)1.65709435
187Limited elbow extension (HP:0001377)1.64822387
188Hepatoblastoma (HP:0002884)1.64785539
189Renovascular hypertension (HP:0100817)1.63921777
190Self-mutilation (HP:0000742)1.63580067
191Patellar dislocation (HP:0002999)1.63347193
192Uterine leiomyosarcoma (HP:0002891)1.62454991
193Leiomyosarcoma (HP:0100243)1.62454991
194Abnormal number of erythroid precursors (HP:0012131)1.62238902
195Abnormality of the tricuspid valve (HP:0001702)1.61445751
196Absent radius (HP:0003974)1.61114568
197Nephroblastoma (Wilms tumor) (HP:0002667)1.59389175
198Chromosomal breakage induced by crosslinking agents (HP:0003221)1.58498223

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA46.55564160
2TRIB35.34479645
3SMG14.70301170
4NTRK34.52929869
5MAP3K93.63412307
6NME23.08810010
7VRK23.06582613
8EEF2K2.92883748
9PKN22.85883778
10MINK12.78604471
11RIPK42.71015853
12KSR22.65180947
13ICK2.64278964
14SIK12.58026185
15EPHA22.55169867
16CDK122.51839250
17DAPK22.51028447
18PRKD32.48140037
19FGFR42.37547185
20MAP3K42.35892835
21RPS6KB22.26216147
22MARK12.10431677
23NTRK12.07364129
24CAMKK12.01257741
25ARAF1.99412849
26PAK61.96683857
27TAF11.96613441
28IRAK31.95844508
29NTRK21.81032421
30KSR11.80721166
31MAP2K71.72314585
32DAPK11.62612226
33FES1.60356193
34CDK51.58058507
35MAP3K131.57969471
36GRK51.55312650
37MAP3K101.52997913
38SIK21.49272528
39MAP3K21.48331360
40CDK71.47827632
41MAP2K41.43088877
42MAP3K121.41860214
43PLK21.39990432
44CDC71.39650117
45BUB11.28518022
46TYRO31.28251258
47PAK41.26767711
48PTK2B1.23058793
49TAOK11.22490277
50PRPF4B1.21721787
51STK381.21342200
52CHEK21.18014259
53MAPKAPK31.17952129
54RAF11.17750579
55TTK1.16070731
56CAMKK21.14849117
57PRKCG1.13457132
58MAP2K21.12088323
59MTOR1.10221466
60TNIK1.08716119
61PBK1.07377930
62BMPR21.04358219
63PNCK0.97635702
64AURKA0.96830916
65CAMK2A0.96728393
66ILK0.95292019
67STK160.92151234
68PINK10.92039804
69MAPK130.91604725
70CASK0.91019305
71PDGFRA0.90821787
72PIK3CA0.85036264
73STK110.84879108
74CDK140.84718062
75SGK4940.84691932
76SGK2230.84691932
77CAMK2B0.84439230
78CDK180.83202417
79PRKCH0.82013838
80UHMK10.81895139
81CDK150.81665809
82FGR0.80304800
83RET0.78465883
84PTK60.77645117
85IRAK20.77554039
86CDK80.76862919
87STK40.76499088
88SGK10.75377536
89TAOK20.74584954
90CAMK10.73795063
91CDK190.73684317
92PLK40.73537645
93LATS20.73117250
94SRPK10.71894043
95AKT20.71516759
96FGFR10.71370364
97PDPK10.71334156
98LMTK20.70733647
99CDK11A0.70084812
100PTK20.69148805
101TESK10.67726040
102CSNK1A1L0.66755501
103PDK10.66744660
104TNK20.66482540
105CSNK1G30.66476985
106BRD40.65837755
107PHKG20.65704351
108PHKG10.65704351
109PRKCI0.65436289
110SGK20.64550303
111FGFR20.64229872
112MARK20.64228290
113MAP3K10.63421579
114TTN0.62954355
115MAP2K10.62893041
116SGK30.62166128
117AURKB0.61289565
118TESK20.59758319
119CHEK10.58616348
120CDK90.57619154
121ALK0.57404556
122RIPK10.55796909
123NEK10.54939957
124PLK10.54882216
125KDR0.54826410
126PRKCZ0.54728155
127MAP3K80.53678958
128LRRK20.52379597
129DYRK1A0.51760256
130ATR0.50928995
131MELK0.50875792
132FYN0.50538142
133DDR20.50252592
134RPS6KC10.50036458
135RPS6KL10.50036458
136PAK30.49442243
137CAMK1D0.49155901
138RPS6KA30.48170801
139NEK60.47883271
140CSNK1E0.47796422
141SCYL20.47526332
142CSNK1G10.47205581
143RPS6KA10.47054579
144MAP2K30.45986990
145MAPKAPK50.45984248
146NME10.45628470
147MAPK110.45461378
148CDK40.45284113
149MAPK100.45163004
150BRAF0.44752125
151PRKCE0.44275299
152CAMK2D0.43577233
153CAMK2G0.42408230
154DAPK30.42084698
155EIF2AK10.41493441
156MUSK0.40887655
157CDK20.40308096
158DYRK1B0.39911074
159CDK10.39305782
160PRKD20.38977076
161FER0.38842793
162BRSK10.38703125
163VRK10.38384827
164OXSR10.38339278
165DYRK30.38287974
166RPS6KB10.37905449
167MOS0.37893177
168CSNK1G20.36709598
169WEE10.36534065
170LATS10.36008293
171FGFR30.35984091
172GRK60.35851251
173PLK30.35316647
174WNK10.35071556
175MAP3K70.33644426
176DMPK0.32611555
177PRKCB0.32284940
178PRKACA0.29689622
179RPS6KA20.29410130

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.40572043
2Olfactory transduction_Homo sapiens_hsa047403.25199854
3Ribosome_Homo sapiens_hsa030103.13159784
4Sulfur relay system_Homo sapiens_hsa041223.11133404
5Long-term potentiation_Homo sapiens_hsa047202.84946944
6Synaptic vesicle cycle_Homo sapiens_hsa047212.81711576
7Circadian entrainment_Homo sapiens_hsa047132.74968699
8Morphine addiction_Homo sapiens_hsa050322.67482072
9Amphetamine addiction_Homo sapiens_hsa050312.67368761
10GABAergic synapse_Homo sapiens_hsa047272.64630582
11Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.57585132
12Glutamatergic synapse_Homo sapiens_hsa047242.57428147
13DNA replication_Homo sapiens_hsa030302.54906485
14Vitamin B6 metabolism_Homo sapiens_hsa007502.42881796
15Dopaminergic synapse_Homo sapiens_hsa047282.35962998
16Salivary secretion_Homo sapiens_hsa049702.23215177
17Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.15965751
18Cholinergic synapse_Homo sapiens_hsa047252.08467402
19Cocaine addiction_Homo sapiens_hsa050302.08244659
20Cyanoamino acid metabolism_Homo sapiens_hsa004602.00717566
21Renin secretion_Homo sapiens_hsa049241.97289864
22Gastric acid secretion_Homo sapiens_hsa049711.93291118
23Biosynthesis of amino acids_Homo sapiens_hsa012301.91895826
24Aldosterone synthesis and secretion_Homo sapiens_hsa049251.89733908
25Insulin secretion_Homo sapiens_hsa049111.81709877
262-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.77683013
27Oxytocin signaling pathway_Homo sapiens_hsa049211.76722124
28Base excision repair_Homo sapiens_hsa034101.73372401
29Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.73267938
30Calcium signaling pathway_Homo sapiens_hsa040201.72384280
31Long-term depression_Homo sapiens_hsa047301.68617599
32Spliceosome_Homo sapiens_hsa030401.68130769
33Taste transduction_Homo sapiens_hsa047421.67994504
34Serotonergic synapse_Homo sapiens_hsa047261.63151622
35Basal cell carcinoma_Homo sapiens_hsa052171.59675496
36Gap junction_Homo sapiens_hsa045401.54946465
37Central carbon metabolism in cancer_Homo sapiens_hsa052301.54871552
38Thyroid cancer_Homo sapiens_hsa052161.53619148
39GnRH signaling pathway_Homo sapiens_hsa049121.51278286
40Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.48335768
41Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.46220165
42Bladder cancer_Homo sapiens_hsa052191.45599284
43Mismatch repair_Homo sapiens_hsa034301.43339718
44Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.42967776
45Pentose phosphate pathway_Homo sapiens_hsa000301.42144615
46Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.39760637
47Folate biosynthesis_Homo sapiens_hsa007901.37159300
48Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.34976712
49cAMP signaling pathway_Homo sapiens_hsa040241.34785590
50Notch signaling pathway_Homo sapiens_hsa043301.34430415
51RNA transport_Homo sapiens_hsa030131.33726522
52Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.33673092
53Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.32729965
54Fructose and mannose metabolism_Homo sapiens_hsa000511.32024337
55One carbon pool by folate_Homo sapiens_hsa006701.24349036
56Hippo signaling pathway_Homo sapiens_hsa043901.23394337
57Glioma_Homo sapiens_hsa052141.23052373
58Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.22819639
59Arginine and proline metabolism_Homo sapiens_hsa003301.20276786
60Estrogen signaling pathway_Homo sapiens_hsa049151.18938617
61Collecting duct acid secretion_Homo sapiens_hsa049661.16595103
62Galactose metabolism_Homo sapiens_hsa000521.16019525
63N-Glycan biosynthesis_Homo sapiens_hsa005101.14989824
64Phosphatidylinositol signaling system_Homo sapiens_hsa040701.14147837
65Pyrimidine metabolism_Homo sapiens_hsa002401.11857462
66Carbon metabolism_Homo sapiens_hsa012001.11428456
67Steroid biosynthesis_Homo sapiens_hsa001001.11336359
68Cell cycle_Homo sapiens_hsa041101.10058368
69mRNA surveillance pathway_Homo sapiens_hsa030151.08803794
70Arginine biosynthesis_Homo sapiens_hsa002201.08645401
71AMPK signaling pathway_Homo sapiens_hsa041521.08098572
72Melanogenesis_Homo sapiens_hsa049161.07724310
73Nucleotide excision repair_Homo sapiens_hsa034201.07450855
74Nitrogen metabolism_Homo sapiens_hsa009101.06614717
75Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.04580722
76RNA polymerase_Homo sapiens_hsa030201.03889985
77* cGMP-PKG signaling pathway_Homo sapiens_hsa040221.03702930
78Phenylalanine metabolism_Homo sapiens_hsa003601.03277329
79Cardiac muscle contraction_Homo sapiens_hsa042601.02329793
80Vascular smooth muscle contraction_Homo sapiens_hsa042701.02138753
81Chronic myeloid leukemia_Homo sapiens_hsa052201.02054144
82Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.01694209
83Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.98498078
84Axon guidance_Homo sapiens_hsa043600.98093028
85* Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.97615139
86Lysine degradation_Homo sapiens_hsa003100.96540835
87Type II diabetes mellitus_Homo sapiens_hsa049300.96411943
88Oocyte meiosis_Homo sapiens_hsa041140.95007887
89Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.94963409
90ErbB signaling pathway_Homo sapiens_hsa040120.93902276
91Phototransduction_Homo sapiens_hsa047440.93638093
92Phospholipase D signaling pathway_Homo sapiens_hsa040720.92628348
93Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.92138848
94Melanoma_Homo sapiens_hsa052180.86509873
95Pancreatic secretion_Homo sapiens_hsa049720.85134979
96Hedgehog signaling pathway_Homo sapiens_hsa043400.84964242
97Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.83382913
98Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.80833668
99Thyroid hormone synthesis_Homo sapiens_hsa049180.80654051
100Vitamin digestion and absorption_Homo sapiens_hsa049770.79417458
101Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.78321881
102Dorso-ventral axis formation_Homo sapiens_hsa043200.77873882
103Cysteine and methionine metabolism_Homo sapiens_hsa002700.76315577
104VEGF signaling pathway_Homo sapiens_hsa043700.75525544
105Pyruvate metabolism_Homo sapiens_hsa006200.72184465
106Choline metabolism in cancer_Homo sapiens_hsa052310.71484160
107Dilated cardiomyopathy_Homo sapiens_hsa054140.70867621
108Alcoholism_Homo sapiens_hsa050340.70316880
109Vibrio cholerae infection_Homo sapiens_hsa051100.69598182
110p53 signaling pathway_Homo sapiens_hsa041150.69348755
111Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.69117700
112Rap1 signaling pathway_Homo sapiens_hsa040150.68872124
113Pentose and glucuronate interconversions_Homo sapiens_hsa000400.67980510
114MicroRNAs in cancer_Homo sapiens_hsa052060.67404758
115Other glycan degradation_Homo sapiens_hsa005110.65996727
116Non-small cell lung cancer_Homo sapiens_hsa052230.65766696
117Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.65212170
118Pancreatic cancer_Homo sapiens_hsa052120.63911877
119Proteoglycans in cancer_Homo sapiens_hsa052050.63872943
120Neurotrophin signaling pathway_Homo sapiens_hsa047220.63617746
121Glucagon signaling pathway_Homo sapiens_hsa049220.62685984
122Fatty acid biosynthesis_Homo sapiens_hsa000610.62601983
123Proteasome_Homo sapiens_hsa030500.62021395
124MAPK signaling pathway_Homo sapiens_hsa040100.61964351
125Homologous recombination_Homo sapiens_hsa034400.61941643
126Small cell lung cancer_Homo sapiens_hsa052220.61745319
127Acute myeloid leukemia_Homo sapiens_hsa052210.61178367
128Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.60654403
129Tight junction_Homo sapiens_hsa045300.59298224
130Tyrosine metabolism_Homo sapiens_hsa003500.58507444
131Prostate cancer_Homo sapiens_hsa052150.58336970
132Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.58003255
133Bile secretion_Homo sapiens_hsa049760.57698125
134Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.56597390
135Ras signaling pathway_Homo sapiens_hsa040140.55069828
136Alzheimers disease_Homo sapiens_hsa050100.54996328
137Sphingolipid signaling pathway_Homo sapiens_hsa040710.54599482
138Thyroid hormone signaling pathway_Homo sapiens_hsa049190.54596687
139Colorectal cancer_Homo sapiens_hsa052100.53892030
140Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.53696322
141Glycosaminoglycan degradation_Homo sapiens_hsa005310.53062392
142Fat digestion and absorption_Homo sapiens_hsa049750.52840562
143Adherens junction_Homo sapiens_hsa045200.52171087
144Carbohydrate digestion and absorption_Homo sapiens_hsa049730.51314314
145Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.49998026
146Prion diseases_Homo sapiens_hsa050200.49264120
147mTOR signaling pathway_Homo sapiens_hsa041500.49181185
148Basal transcription factors_Homo sapiens_hsa030220.47931355
149Glutathione metabolism_Homo sapiens_hsa004800.47195314
150Fatty acid elongation_Homo sapiens_hsa000620.46347476
151Type I diabetes mellitus_Homo sapiens_hsa049400.45987358
152Purine metabolism_Homo sapiens_hsa002300.45376449
153Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.44936511
154African trypanosomiasis_Homo sapiens_hsa051430.44935048
155Endocytosis_Homo sapiens_hsa041440.44735969
156Fanconi anemia pathway_Homo sapiens_hsa034600.44058958
157Endometrial cancer_Homo sapiens_hsa052130.42616925
158Chemokine signaling pathway_Homo sapiens_hsa040620.40991702
159Longevity regulating pathway - mammal_Homo sapiens_hsa042110.40762992
160Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.40343710
161Inositol phosphate metabolism_Homo sapiens_hsa005620.40003945
162Insulin signaling pathway_Homo sapiens_hsa049100.38928501
163Parkinsons disease_Homo sapiens_hsa050120.38461548
164Renal cell carcinoma_Homo sapiens_hsa052110.36848561
165Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.36190965
166Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.35762946
167Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.32962081
168Platelet activation_Homo sapiens_hsa046110.32609047
169Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.31406317
170Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.30047853
171Ovarian steroidogenesis_Homo sapiens_hsa049130.29202087
172Wnt signaling pathway_Homo sapiens_hsa043100.26492944
173Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.26343793
174Circadian rhythm_Homo sapiens_hsa047100.25670747
175Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.25069578
176Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.24724275
177Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.23991137

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