ADPGK

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: ADPGK (EC 2.7.1.147) catalyzes the ADP-dependent phosphorylation of glucose to glucose-6-phosphate and may play a role in glycolysis, possibly during ischemic conditions (Ronimus and Morgan, 2004 [PubMed 14975750]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1doxorubicin metabolic process (GO:0044598)8.47144858
2daunorubicin metabolic process (GO:0044597)8.47144858
3polyketide metabolic process (GO:0030638)8.47144858
4protein localization to kinetochore (GO:0034501)6.71383029
5maintenance of protein location in nucleus (GO:0051457)6.06026360
6negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)5.56922938
7positive regulation of gamma-delta T cell activation (GO:0046645)5.56139496
8regulation of telomere maintenance via telomerase (GO:0032210)5.37159552
9regulation of nuclear cell cycle DNA replication (GO:0033262)5.36386345
10aminoglycoside antibiotic metabolic process (GO:0030647)5.34955122
11regulation of mammary gland epithelial cell proliferation (GO:0033599)5.32407508
12mitotic sister chromatid segregation (GO:0000070)5.18640580
13negative regulation of cell cycle G2/M phase transition (GO:1902750)5.14307846
14protein localization to chromosome, centromeric region (GO:0071459)5.10919520
15negative regulation of epidermis development (GO:0045683)5.09035343
16somite rostral/caudal axis specification (GO:0032525)5.00324073
17negative regulation of telomerase activity (GO:0051974)4.98685486
18regulation of response to osmotic stress (GO:0047484)4.78404164
19rRNA transcription (GO:0009303)4.74223104
20heterochromatin organization (GO:0070828)4.70159447
21histone H4-K8 acetylation (GO:0043982)4.64555303
22histone H4-K5 acetylation (GO:0043981)4.64555303
23histone H4-K12 acetylation (GO:0043983)4.61611462
24DNA replication checkpoint (GO:0000076)4.60567681
25DNA replication-dependent nucleosome organization (GO:0034723)4.60278882
26DNA replication-dependent nucleosome assembly (GO:0006335)4.60278882
27muscle organ morphogenesis (GO:0048644)4.60218910
28positive regulation of DNA-dependent DNA replication (GO:2000105)4.51320911
29neutrophil activation involved in immune response (GO:0002283)4.48245129
30negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)4.47645113
31sister chromatid segregation (GO:0000819)4.46675197
32negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.44041235
33negative regulation of cell killing (GO:0031342)4.44041235
34nuclear pore complex assembly (GO:0051292)4.40211103
35negative regulation of interleukin-12 production (GO:0032695)4.34668981
36cellular extravasation (GO:0045123)4.34088201
37regulation of translation in response to stress (GO:0043555)4.32413037
38modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.19780438
39positive regulation by organism of defense response of other organism involved in symbiotic interact4.19780438
40modulation by symbiont of host immune response (GO:0052553)4.19780438
41positive regulation by symbiont of host defense response (GO:0052509)4.19780438
42modulation by symbiont of host defense response (GO:0052031)4.19780438
43modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.19780438
44regulation of MHC class I biosynthetic process (GO:0045343)4.18543058
45antigen processing and presentation of endogenous antigen (GO:0019883)4.18288423
46antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.17464289
47chromatin assembly (GO:0031497)4.13319582
48immunoglobulin mediated immune response (GO:0016064)4.11581959
49antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.97767107
50regulation of gamma-delta T cell activation (GO:0046643)3.96869041
51nuclear pore organization (GO:0006999)3.94562257
52negative regulation of epidermal cell differentiation (GO:0045605)3.93548983
53negative regulation of telomere maintenance (GO:0032205)3.91722960
54interferon-gamma production (GO:0032609)3.91402113
55notochord development (GO:0030903)3.87588725
56regulation of B cell receptor signaling pathway (GO:0050855)3.83320516
57rRNA methylation (GO:0031167)3.80991716
58detection of other organism (GO:0098543)3.78610299
59antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.71630006
60response to muramyl dipeptide (GO:0032495)3.69268583
61macrophage activation involved in immune response (GO:0002281)3.67906280
62positive regulation of protein deacetylation (GO:0090312)3.66921439
63maintenance of protein localization in organelle (GO:0072595)3.66677304
64DNA unwinding involved in DNA replication (GO:0006268)3.64095570
65mitotic chromosome condensation (GO:0007076)3.63896153
66rRNA modification (GO:0000154)3.63728298
67detection of bacterium (GO:0016045)3.60449796
68histone H4-K16 acetylation (GO:0043984)3.58765298
69positive regulation of B cell differentiation (GO:0045579)3.57607366
70RNA stabilization (GO:0043489)3.56971269
71mRNA stabilization (GO:0048255)3.56971269
72defense response to protozoan (GO:0042832)3.53401033
73hormone catabolic process (GO:0042447)3.52574818
74primitive streak formation (GO:0090009)3.51346820
75regulation of gamma-delta T cell differentiation (GO:0045586)3.50717394
76cytidine catabolic process (GO:0006216)3.50701244
77cytidine deamination (GO:0009972)3.50701244
78cytidine metabolic process (GO:0046087)3.50701244
79regulation of apoptotic process involved in morphogenesis (GO:1902337)3.49798029
80T cell migration (GO:0072678)3.49778388
81DNA duplex unwinding (GO:0032508)3.46851585
82negative regulation of erythrocyte differentiation (GO:0045647)3.46812519
83pre-miRNA processing (GO:0031054)3.45666066
84positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.42948998
85regulation of mast cell degranulation (GO:0043304)3.42847680
86nucleoside transmembrane transport (GO:1901642)3.42754085
87DNA geometric change (GO:0032392)3.41882649
88positive regulation of histone deacetylation (GO:0031065)3.37432200
89maternal placenta development (GO:0001893)3.33011528
90response to protozoan (GO:0001562)3.32741458
91formation of translation preinitiation complex (GO:0001731)3.32216704
92leukocyte aggregation (GO:0070486)3.31193397
93intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (GO:0042771)3.30912965
94pentose-phosphate shunt (GO:0006098)3.26843178
95B cell receptor signaling pathway (GO:0050853)3.25135630
96pore complex assembly (GO:0046931)3.24294561
97branching involved in mammary gland duct morphogenesis (GO:0060444)3.23078661
98B cell mediated immunity (GO:0019724)3.20629487
99trophectodermal cell differentiation (GO:0001829)3.20083178
100respiratory burst (GO:0045730)3.19601917
101ribosome biogenesis (GO:0042254)3.19402004
102negative regulation of phagocytosis (GO:0050765)3.18712621
103myeloid cell activation involved in immune response (GO:0002275)3.18349642
104negative regulation of T cell mediated immunity (GO:0002710)3.17713150
105detection of external biotic stimulus (GO:0098581)3.17168622
106regulation of interferon-beta biosynthetic process (GO:0045357)3.15712688
107apoptotic DNA fragmentation (GO:0006309)3.15134569
108neutrophil activation (GO:0042119)3.13877902
109negative thymic T cell selection (GO:0045060)3.13795204
110regulation of mast cell activation involved in immune response (GO:0033006)3.13436987
111regulation of dendritic cell antigen processing and presentation (GO:0002604)3.13051584
112regulation of myeloid leukocyte mediated immunity (GO:0002886)3.12797712
113regulation of leukocyte degranulation (GO:0043300)3.12277490
114interferon-gamma-mediated signaling pathway (GO:0060333)3.10361986
115positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.10313018
116lipopolysaccharide-mediated signaling pathway (GO:0031663)3.09929884
117neutrophil mediated immunity (GO:0002446)3.09695461
118regulation of B cell differentiation (GO:0045577)3.09411540
119regulation of cilium movement (GO:0003352)3.08257861
120regulation of telomere maintenance (GO:0032204)3.07698969
121granulocyte activation (GO:0036230)3.07615757
122retinoic acid receptor signaling pathway (GO:0048384)3.07449135
123leukocyte migration involved in inflammatory response (GO:0002523)3.06874004
124phenol-containing compound catabolic process (GO:0019336)3.05200305
125positive thymic T cell selection (GO:0045059)3.04769867
126regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.03939082
127germinal center formation (GO:0002467)3.03886213
128DNA replication initiation (GO:0006270)3.03749446
129DNA damage response, detection of DNA damage (GO:0042769)3.03642107
130detection of molecule of bacterial origin (GO:0032490)3.03137010
131positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.02892442
132response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.02651117
133response to host immune response (GO:0052572)3.02651117
134positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.01081108
135regulation of telomerase activity (GO:0051972)3.00910405
136type I interferon signaling pathway (GO:0060337)2.99991464
137cellular response to type I interferon (GO:0071357)2.99991464
138response to type I interferon (GO:0034340)2.99255971
139coenzyme catabolic process (GO:0009109)2.97545623
140cell fate commitment involved in formation of primary germ layer (GO:0060795)2.97179260
141negative T cell selection (GO:0043383)2.95901444
142regulation of posttranscriptional gene silencing (GO:0060147)2.95397422
143regulation of gene silencing by miRNA (GO:0060964)2.95397422
144regulation of gene silencing by RNA (GO:0060966)2.95397422
145positive regulation of antigen processing and presentation (GO:0002579)2.94771236
146regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.93966612
147regulation of antigen processing and presentation (GO:0002577)2.93897560
148NIK/NF-kappaB signaling (GO:0038061)2.93657332
149microglial cell activation (GO:0001774)2.93606213
150positive regulation of mast cell activation (GO:0033005)2.92708499
151regulation of DNA-dependent DNA replication (GO:0090329)2.92622066
152response to peptidoglycan (GO:0032494)2.92551771
153quinone metabolic process (GO:1901661)2.92292766
154negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.92167054
155intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)2.91991606
156spindle assembly (GO:0051225)2.90398356
157negative regulation of lymphocyte mediated immunity (GO:0002707)2.89701940
158cellular modified amino acid catabolic process (GO:0042219)2.88319412
159response to dietary excess (GO:0002021)2.87251033
160positive regulation of granulocyte differentiation (GO:0030854)2.87175927
161regulation of mast cell activation (GO:0033003)2.87174705
162regulation of double-strand break repair (GO:2000779)2.86895552
163intestinal epithelial cell development (GO:0060576)2.83927491
164detection of biotic stimulus (GO:0009595)2.83899472
165response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.83738730
166response to host (GO:0075136)2.83738730
167response to host defenses (GO:0052200)2.83738730
168primary alcohol catabolic process (GO:0034310)2.83728067
169adaptation of signaling pathway (GO:0023058)2.83452299
170positive regulation of interferon-alpha production (GO:0032727)2.83246391
171negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.83165950
172negative regulation of T-helper cell differentiation (GO:0045623)2.83165950
173mitochondrial DNA replication (GO:0006264)2.82743646
174regulation of tolerance induction (GO:0002643)2.82038628
175pseudouridine synthesis (GO:0001522)2.81588625
176regulation of interferon-alpha production (GO:0032647)2.81415534
177NADPH regeneration (GO:0006740)2.81245486
178macrophage activation (GO:0042116)2.80888240
179defense response to fungus (GO:0050832)2.80393918
180regulation of odontogenesis of dentin-containing tooth (GO:0042487)2.80097111
181T cell selection (GO:0045058)2.78966238
182T-helper 1 type immune response (GO:0042088)2.78308932
183negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.78286606
184positive regulation of mast cell degranulation (GO:0043306)2.77444471
185positive regulation of mast cell activation involved in immune response (GO:0033008)2.77444471
186negative regulation of leukocyte mediated immunity (GO:0002704)2.76622891
187regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.76386991
188response to interleukin-15 (GO:0070672)2.76068186
189positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.75706089
190regulation of T cell tolerance induction (GO:0002664)2.74264864
191positive regulation of isotype switching (GO:0045830)2.72806161
192negative regulation of cytokine production involved in immune response (GO:0002719)2.71540485
193regulation of alpha-beta T cell proliferation (GO:0046640)2.70516041
194negative regulation of innate immune response (GO:0045824)2.69250294
195negative regulation of interleukin-6 production (GO:0032715)2.68617427
196antigen processing and presentation via MHC class Ib (GO:0002475)2.67929486
197leukocyte degranulation (GO:0043299)2.66996641
198regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.66102508

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.30675385
2IRF8_22096565_ChIP-ChIP_GC-B_Human5.48803531
3BP1_19119308_ChIP-ChIP_Hs578T_Human5.06477639
4KLF2_18264089_ChIP-ChIP_MESCs_Mouse4.84612851
5KLF5_18264089_ChIP-ChIP_MESCs_Mouse4.84612851
6KLF4_18264089_ChIP-ChIP_MESCs_Mouse4.84612851
7IRF8_21731497_ChIP-ChIP_J774_Mouse3.70218289
8MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.45160177
9NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.37683054
10STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.27812101
11FOXM1_23109430_ChIP-Seq_U2OS_Human3.20485837
12SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.17208235
13FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.98847993
14IRF8_27001747_Chip-Seq_BMDM_Mouse2.97844375
15E2F4_17652178_ChIP-ChIP_JURKAT_Human2.85832740
16NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.83556229
17* VDR_24763502_ChIP-Seq_THP-1_Human2.75655331
18* SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.67850779
19IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.58929736
20IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.57874068
21POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.44584318
22MYB_26560356_Chip-Seq_TH2_Human2.42894970
23SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.40949026
24STAT4_19710469_ChIP-ChIP_TH1__Mouse2.39786175
25TP63_19390658_ChIP-ChIP_HaCaT_Human2.37637402
26NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.32864018
27STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.29403418
28FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.28237422
29RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.25308560
30* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.19472986
31RUNX_20019798_ChIP-Seq_JUKART_Human2.18170069
32MYC_22102868_ChIP-Seq_BL_Human2.12150619
33SPI1_23127762_ChIP-Seq_K562_Human2.10655094
34* MYC_18555785_ChIP-Seq_MESCs_Mouse2.07858892
35TCF3_18692474_ChIP-Seq_MEFs_Mouse1.98641257
36* SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.97538280
37RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.97216129
38FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.96847816
39VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.92447926
40NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.90583594
41Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.90254836
42CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.88353632
43EGR1_19374776_ChIP-ChIP_THP-1_Human1.87540557
44* TCF3_18692474_ChIP-Seq_MESCs_Mouse1.82860748
45STAT3_1855785_ChIP-Seq_MESCs_Mouse1.81917469
46MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.79920218
47ELF1_17652178_ChIP-ChIP_JURKAT_Human1.73596703
48* MYC_19079543_ChIP-ChIP_MESCs_Mouse1.72669406
49MAF_26560356_Chip-Seq_TH2_Human1.70019280
50SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.69977289
51NANOG_18555785_ChIP-Seq_MESCs_Mouse1.65427822
52* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.65368219
53KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.64043282
54* VDR_24787735_ChIP-Seq_THP-1_Human1.63909869
55FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.61128668
56KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.53689690
57HIF1A_21447827_ChIP-Seq_MCF-7_Human1.51256762
58* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.51034001
59GATA3_27048872_Chip-Seq_THYMUS_Human1.50405825
60ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.48724608
61* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.48262677
62MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.48157022
63NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.47208088
64KDM2B_26808549_Chip-Seq_DND41_Human1.46072152
65GATA1_22025678_ChIP-Seq_K562_Human1.45842204
66NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.45282928
67* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.44598878
68GATA2_22383799_ChIP-Seq_G1ME_Mouse1.43478853
69ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.42621466
70CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.42233520
71* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.41997121
72PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.37846605
73LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.37275888
74POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.36946348
75MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.36336725
76PU_27001747_Chip-Seq_BMDM_Mouse1.35041382
77SCL_19346495_ChIP-Seq_HPC-7_Human1.34447426
78GATA1_19941827_ChIP-Seq_MEL_Mouse1.33452407
79TCF7_22412390_ChIP-Seq_EML_Mouse1.33416607
80GATA1_22383799_ChIP-Seq_G1ME_Mouse1.32711314
81VDR_21846776_ChIP-Seq_THP-1_Human1.32408313
82CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.32361992
83* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.32199836
84CREB1_15753290_ChIP-ChIP_HEK293T_Human1.31473765
85TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.30530355
86PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.29581666
87CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.24977974
88POU5F1_16518401_ChIP-PET_MESCs_Mouse1.23792419
89* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.23507350
90LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.22970343
91NOTCH1_21737748_ChIP-Seq_TLL_Human1.21260390
92GATA3_26560356_Chip-Seq_TH2_Human1.20554910
93YY1_21170310_ChIP-Seq_MESCs_Mouse1.18482896
94RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.17159811
95OCT4_18692474_ChIP-Seq_MEFs_Mouse1.15643377
96MYB_21317192_ChIP-Seq_ERMYB_Mouse1.15386360
97LXR_22292898_ChIP-Seq_THP-1_Human1.14900547
98PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.14808264
99AR_21909140_ChIP-Seq_LNCAP_Human1.14764980
100KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.13879270
101NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.13790249
102NCOR1_26117541_ChIP-Seq_K562_Human1.13610103
103ELK3_25401928_ChIP-Seq_HUVEC_Human1.13378134
104PU.1_20513432_ChIP-Seq_Bcells_Mouse1.12971737
105POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.12635629
106* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.12603408
107SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.12232228
108* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.12159105
109STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.11699852
110CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.11487130
111SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.10824245
112ESR1_15608294_ChIP-ChIP_MCF-7_Human1.10704419
113CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.09750144
114IRF1_19129219_ChIP-ChIP_H3396_Human1.09237231
115KLF4_18555785_ChIP-Seq_MESCs_Mouse1.08965222
116SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.07998765
117SPI1_23547873_ChIP-Seq_NB4_Human1.07847173
118* NANOG_18692474_ChIP-Seq_MEFs_Mouse1.07610713
119NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.06583225
120GATA1_19941826_ChIP-Seq_K562_Human1.06465087
121ZFP281_18757296_ChIP-ChIP_E14_Mouse1.05220481
122SOX2_18555785_ChIP-Seq_MESCs_Mouse1.05114820
123KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.04909022
124* NANOG_18692474_ChIP-Seq_MESCs_Mouse1.04412034
125E2F1_18555785_ChIP-Seq_MESCs_Mouse1.03184688
126EST1_17652178_ChIP-ChIP_JURKAT_Human1.03106298
127FOXP3_21729870_ChIP-Seq_TREG_Human1.02711362
128* TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.01555114
129XRN2_22483619_ChIP-Seq_HELA_Human1.01247807
130SMAD_19615063_ChIP-ChIP_OVARY_Human1.00987569
131SOX2_18692474_ChIP-Seq_MESCs_Mouse1.00454309
132* KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.99982479
133* BCL6_27268052_Chip-Seq_Bcells_Human0.99157152
134KDM2B_26808549_Chip-Seq_SUP-B15_Human0.99053821
135* NELFA_20434984_ChIP-Seq_ESCs_Mouse0.98194582
136SOX2_18692474_ChIP-Seq_MEFs_Mouse0.97518470
137* BRD4_27068464_Chip-Seq_AML-cells_Mouse0.97327527
138NANOG_21062744_ChIP-ChIP_HESCs_Human0.97028154
139ELF1_20517297_ChIP-Seq_JURKAT_Human0.97014780
140* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.96932690
141TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.96547304
142ZFP281_27345836_Chip-Seq_ESCs_Mouse0.96193399
143STAT6_21828071_ChIP-Seq_BEAS2B_Human0.95630237
144ERG_20887958_ChIP-Seq_HPC-7_Mouse0.94893376
145RUNX1_22412390_ChIP-Seq_EML_Mouse0.94742489
146PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.93887694
147STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.92720997
148MYCN_18555785_ChIP-Seq_MESCs_Mouse0.91669111
149* BCOR_27268052_Chip-Seq_Bcells_Human0.91400228
150RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91393064
151E2F1_21310950_ChIP-Seq_MCF-7_Human0.91134808
152KDM2B_26808549_Chip-Seq_JURKAT_Human0.90672596
153GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90237192
154E2F1_17053090_ChIP-ChIP_MCF-7_Human0.89862617
155CIITA_25753668_ChIP-Seq_RAJI_Human0.88952916
156E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.87773188
157* TP53_22127205_ChIP-Seq_IMR90_Human0.87768600
158* KDM5A_27292631_Chip-Seq_BREAST_Human0.86927199
159TFEB_21752829_ChIP-Seq_HELA_Human0.86819554
160NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.86785432
161ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.86585604
162NANOG_16518401_ChIP-PET_MESCs_Mouse0.85312963
163MYB_26560356_Chip-Seq_TH1_Human0.84960620
164* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.84431541
165CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.84321001
166CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.84033496
167GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83439821
168TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.83270098
169MAF_26560356_Chip-Seq_TH1_Human0.83062275
170PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.82928196
171CTCF_27219007_Chip-Seq_ERYTHROID_Human0.82757489
172GABP_19822575_ChIP-Seq_HepG2_Human0.82729152
173GATA2_21666600_ChIP-Seq_HMVEC_Human0.82487198
174* UTX_26944678_Chip-Seq_JUKART_Human0.82222810

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.93548978
2MP0004264_abnormal_extraembryonic_tissu3.89438470
3MP0003011_delayed_dark_adaptation3.58691344
4MP0002254_reproductive_system_inflammat3.56340984
5MP0008057_abnormal_DNA_replication3.28728980
6MP0004957_abnormal_blastocyst_morpholog3.17939424
7MP0003724_increased_susceptibility_to3.10959515
8MP0002419_abnormal_innate_immunity2.92374429
9MP0005671_abnormal_response_to2.91450385
10MP0006292_abnormal_olfactory_placode2.90676101
11MP0005000_abnormal_immune_tolerance2.80978395
12MP0003890_abnormal_embryonic-extraembry2.80235037
13MP0000685_abnormal_immune_system2.79014187
14MP0005075_abnormal_melanosome_morpholog2.78545725
15MP0005387_immune_system_phenotype2.75453769
16MP0001790_abnormal_immune_system2.75453769
17MP0005025_abnormal_response_to2.71543825
18MP0010352_gastrointestinal_tract_polyps2.70516411
19MP0003705_abnormal_hypodermis_morpholog2.67790143
20MP0002148_abnormal_hypersensitivity_rea2.56063949
21MP0002452_abnormal_antigen_presenting2.53732765
22MP0005058_abnormal_lysosome_morphology2.52724926
23MP0002723_abnormal_immune_serum2.48549019
24MP0003183_abnormal_peptide_metabolism2.45800761
25MP0002420_abnormal_adaptive_immunity2.40176761
26MP0003172_abnormal_lysosome_physiology2.39919002
27MP0001819_abnormal_immune_cell2.38943039
28MP0003300_gastrointestinal_ulcer2.31176675
29MP0003763_abnormal_thymus_physiology2.28198662
30MP0005394_taste/olfaction_phenotype2.22043053
31MP0005499_abnormal_olfactory_system2.22043053
32MP0004858_abnormal_nervous_system2.20508721
33MP0003191_abnormal_cellular_cholesterol2.12883442
34MP0002396_abnormal_hematopoietic_system2.11472678
35MP0003077_abnormal_cell_cycle2.03862387
36MP0003121_genomic_imprinting2.03562669
37MP0002332_abnormal_exercise_endurance2.01071971
38MP0003123_paternal_imprinting1.99605586
39MP0005464_abnormal_platelet_physiology1.97826869
40MP0003111_abnormal_nucleus_morphology1.95912194
41MP0003122_maternal_imprinting1.89886052
42MP0009840_abnormal_foam_cell1.88767085
43MP0004947_skin_inflammation1.88011228
44MP0005380_embryogenesis_phenotype1.86678010
45MP0001672_abnormal_embryogenesis/_devel1.86678010
46MP0010155_abnormal_intestine_physiology1.82831273
47MP0002653_abnormal_ependyma_morphology1.82744109
48MP0001533_abnormal_skeleton_physiology1.82282766
49MP0003693_abnormal_embryo_hatching1.79643563
50MP0006035_abnormal_mitochondrial_morpho1.79150732
51MP0005451_abnormal_body_composition1.78750252
52MP0000350_abnormal_cell_proliferation1.78402845
53MP0002088_abnormal_embryonic_growth/wei1.75319785
54MP0003984_embryonic_growth_retardation1.75236915
55MP0010094_abnormal_chromosome_stability1.75025433
56MP0009333_abnormal_splenocyte_physiolog1.74059932
57MP0003436_decreased_susceptibility_to1.73613078
58MP0001845_abnormal_inflammatory_respons1.72340961
59MP0005257_abnormal_intraocular_pressure1.63486186
60MP0000465_gastrointestinal_hemorrhage1.56322977
61MP0001873_stomach_inflammation1.54752277
62MP0002277_abnormal_respiratory_mucosa1.54254895
63MP0009764_decreased_sensitivity_to1.50794715
64MP0005310_abnormal_salivary_gland1.49990554
65MP0000490_abnormal_crypts_of1.49972768
66MP0008469_abnormal_protein_level1.49033051
67MP0008961_abnormal_basal_metabolism1.48684564
68MP0008260_abnormal_autophagy1.48671794
69MP0002086_abnormal_extraembryonic_tissu1.47534384
70MP0005023_abnormal_wound_healing1.46655100
71MP0000678_abnormal_parathyroid_gland1.42596520
72MP0002166_altered_tumor_susceptibility1.41283852
73MP0002998_abnormal_bone_remodeling1.35673282
74MP0001849_ear_inflammation1.33626065
75MP0001293_anophthalmia1.32617126
76MP0002085_abnormal_embryonic_tissue1.29557974
77MP0001730_embryonic_growth_arrest1.29093492
78MP0006082_CNS_inflammation1.28592229
79MP0003656_abnormal_erythrocyte_physiolo1.28208345
80MP0002932_abnormal_joint_morphology1.24159539
81MP0002092_abnormal_eye_morphology1.21652692
82MP0003303_peritoneal_inflammation1.21423877
83MP0003075_altered_response_to1.20071837
84MP0004197_abnormal_fetal_growth/weight/1.19774638
85MP0000858_altered_metastatic_potential1.18983782
86MP0003938_abnormal_ear_development1.17446229
87MP0000313_abnormal_cell_death1.16925480
88MP0000604_amyloidosis1.15600915
89MP0002084_abnormal_developmental_patter1.13684647
90MP0010030_abnormal_orbit_morphology1.13632780
91MP0003866_abnormal_defecation1.11491000
92MP0009278_abnormal_bone_marrow1.10270616
93MP0001697_abnormal_embryo_size1.10052678
94MP0002006_tumorigenesis1.06427450
95MP0002009_preneoplasia1.06397608
96MP0003566_abnormal_cell_adhesion1.06123912
97MP0000343_altered_response_to1.05270561
98MP0002080_prenatal_lethality1.04656332
99MP0002970_abnormal_white_adipose1.04651336
100MP0002405_respiratory_system_inflammati1.04082548
101MP0008932_abnormal_embryonic_tissue1.03575190
102MP0005266_abnormal_metabolism1.03331525
103MP0002127_abnormal_cardiovascular_syste1.02556998
104MP0008004_abnormal_stomach_pH0.99781920
105MP0001851_eye_inflammation0.98936909
106MP0002019_abnormal_tumor_incidence0.98024805
107MP0005164_abnormal_response_to0.95605082
108MP0003448_altered_tumor_morphology0.94900031
109MP0002722_abnormal_immune_system0.94120807
110MP0000689_abnormal_spleen_morphology0.93908446
111MP0004808_abnormal_hematopoietic_stem0.93308388
112MP0004381_abnormal_hair_follicle0.93227383
113MP0002132_abnormal_respiratory_system0.92920492
114MP0009763_increased_sensitivity_to0.90176215
115MP0004883_abnormal_blood_vessel0.90005321
116MP0005166_decreased_susceptibility_to0.89389616
117MP0002925_abnormal_cardiovascular_devel0.89368730
118MP0001545_abnormal_hematopoietic_system0.88102843
119MP0005397_hematopoietic_system_phenotyp0.88102843
120MP0003119_abnormal_digestive_system0.87859695
121MP0008007_abnormal_cellular_replicative0.87455375
122MP0002933_joint_inflammation0.86889682
123MP0000428_abnormal_craniofacial_morphol0.86889410
124MP0008770_decreased_survivor_rate0.86775609
125MP0003806_abnormal_nucleotide_metabolis0.85913541
126MP0001853_heart_inflammation0.85564836
127MP0002398_abnormal_bone_marrow0.84062816
128MP0002138_abnormal_hepatobiliary_system0.83835448
129MP0000358_abnormal_cell_content/0.82467061
130MP0002114_abnormal_axial_skeleton0.80998820
131MP0000762_abnormal_tongue_morphology0.79906463
132MP0002429_abnormal_blood_cell0.79813908
133MP0009785_altered_susceptibility_to0.79631181
134MP0004510_myositis0.79504945
135MP0005390_skeleton_phenotype0.78752802
136MP0000432_abnormal_head_morphology0.78723079
137MP0003091_abnormal_cell_migration0.77653654
138MP0000015_abnormal_ear_pigmentation0.77159128
139MP0005384_cellular_phenotype0.76605796
140MP0009765_abnormal_xenobiotic_induced0.76189099
141MP0003315_abnormal_perineum_morphology0.75021756
142MP0001348_abnormal_lacrimal_gland0.74932397
143MP0002877_abnormal_melanocyte_morpholog0.74635225
144MP0001800_abnormal_humoral_immune0.73309324
145MP0001663_abnormal_digestive_system0.73062888
146MP0008789_abnormal_olfactory_epithelium0.72637837
147MP0000049_abnormal_middle_ear0.72381750
148MP0003795_abnormal_bone_structure0.70942786
149MP0003935_abnormal_craniofacial_develop0.70110706
150MP0005076_abnormal_cell_differentiation0.69581222
151MP0000716_abnormal_immune_system0.69470625
152MP0000703_abnormal_thymus_morphology0.69302961
153MP0003828_pulmonary_edema0.69208077
154MP0009703_decreased_birth_body0.69079104
155MP0003453_abnormal_keratinocyte_physiol0.68021109
156MP0003690_abnormal_glial_cell0.67284496
157MP0004133_heterotaxia0.65584767
158MP0002233_abnormal_nose_morphology0.65201468
159MP0000249_abnormal_blood_vessel0.63595940
160MP0010307_abnormal_tumor_latency0.63125916
161MP0000609_abnormal_liver_physiology0.60737077
162MP0005319_abnormal_enzyme/_coenzyme0.58836053
163MP0003221_abnormal_cardiomyocyte_apopto0.57668236
164MP0006054_spinal_hemorrhage0.57656526
165MP0005621_abnormal_cell_physiology0.51359124
166MP0000371_diluted_coat_color0.50224231
167MP0009115_abnormal_fat_cell0.48536858

Predicted human phenotypes

RankGene SetZ-score
1Bilateral microphthalmos (HP:0007633)6.34881424
2Hypochromic microcytic anemia (HP:0004840)5.62044711
3Recurrent bacterial skin infections (HP:0005406)5.14879646
4Recurrent abscess formation (HP:0002722)5.12505798
5Multiple enchondromatosis (HP:0005701)4.88790284
6Hepatoblastoma (HP:0002884)4.71733989
7Abnormality of macrophages (HP:0004311)4.68701483
8Myositis (HP:0100614)4.52600168
9Rib fusion (HP:0000902)4.36313556
10Abnormality of glycolipid metabolism (HP:0010969)4.30860892
11Abnormality of liposaccharide metabolism (HP:0010968)4.30860892
12Abnormality of glycosphingolipid metabolism (HP:0004343)4.30860892
13Ependymoma (HP:0002888)4.27402420
14Stomatitis (HP:0010280)4.19202807
15Abnormality of the lower motor neuron (HP:0002366)4.17981881
16Orchitis (HP:0100796)4.00913772
17Recurrent fungal infections (HP:0002841)3.98964119
18Mediastinal lymphadenopathy (HP:0100721)3.97667410
19Elevated erythrocyte sedimentation rate (HP:0003565)3.87575996
20Optic neuritis (HP:0100653)3.83727759
21Retrobulbar optic neuritis (HP:0100654)3.83727759
22Chromosomal breakage induced by crosslinking agents (HP:0003221)3.76535000
23Recurrent cutaneous fungal infections (HP:0011370)3.68887173
24Chronic mucocutaneous candidiasis (HP:0002728)3.68887173
25Recurrent gram-negative bacterial infections (HP:0005420)3.62919721
26Recurrent skin infections (HP:0001581)3.62511205
27Recurrent viral infections (HP:0004429)3.59693580
28Neoplasm of striated muscle (HP:0009728)3.54175029
29Chronic obstructive pulmonary disease (HP:0006510)3.53645668
30Obstructive lung disease (HP:0006536)3.53645668
31Rhabdomyosarcoma (HP:0002859)3.52962911
32Meningitis (HP:0001287)3.50070217
33Increased cerebral lipofuscin (HP:0011813)3.43375821
34Nephroblastoma (Wilms tumor) (HP:0002667)3.32754380
35Abnormal delayed hypersensitivity skin test (HP:0002963)3.29474382
36Chromsome breakage (HP:0040012)3.28657393
37Gastrointestinal infarctions (HP:0005244)3.28630223
38Dysostosis multiplex (HP:0000943)3.15643387
39T lymphocytopenia (HP:0005403)3.14925222
40Fused cervical vertebrae (HP:0002949)3.12735976
41Vacuolated lymphocytes (HP:0001922)3.11934347
42Vasculitis (HP:0002633)3.09774979
43Embryonal renal neoplasm (HP:0011794)3.07599225
44Hemoptysis (HP:0002105)3.01793022
45Pulmonary infiltrates (HP:0002113)2.98623953
46Increased neuronal autofluorescent lipopigment (HP:0002074)2.97971277
47Testicular atrophy (HP:0000029)2.96120240
48Loss of speech (HP:0002371)2.95551974
49Aplasia/hypoplasia of the humerus (HP:0006507)2.93160247
50Astrocytoma (HP:0009592)2.92482428
51Abnormality of the astrocytes (HP:0100707)2.92482428
52Hypochromic anemia (HP:0001931)2.92413290
53Encephalitis (HP:0002383)2.90887176
54Short humerus (HP:0005792)2.89892134
55Agammaglobulinemia (HP:0004432)2.89650598
56Abnormality of T cell number (HP:0011839)2.89106980
57Cellulitis (HP:0100658)2.87434478
58Pustule (HP:0200039)2.85961505
59Trismus (HP:0000211)2.84966582
60Ragged-red muscle fibers (HP:0003200)2.83891031
61Rectal fistula (HP:0100590)2.81961782
62Rectovaginal fistula (HP:0000143)2.81961782
63Amyotrophic lateral sclerosis (HP:0007354)2.81449227
64Panhypogammaglobulinemia (HP:0003139)2.77209441
65Chest pain (HP:0100749)2.76233080
66Urticaria (HP:0001025)2.73201715
67Colitis (HP:0002583)2.72763731
68Spontaneous hematomas (HP:0007420)2.70791985
69Reduced antithrombin III activity (HP:0001976)2.69951467
70Keratoconjunctivitis sicca (HP:0001097)2.69799299
71Abnormality of the salivary glands (HP:0010286)2.67862659
72Increased IgE level (HP:0003212)2.65007156
73Abnormal lung lobation (HP:0002101)2.63702021
74Abnormal cartilage morphology (HP:0002763)2.63309043
75Thrombocytosis (HP:0001894)2.63211562
76Intestinal fistula (HP:0100819)2.61382938
77Autoimmune thrombocytopenia (HP:0001973)2.60248846
78Granulocytopenia (HP:0001913)2.60235245
79Preauricular skin tag (HP:0000384)2.58662154
80Meckel diverticulum (HP:0002245)2.57957798
81Aplasia/Hypoplasia of the fovea (HP:0008060)2.56835968
82Hypoplasia of the fovea (HP:0007750)2.56835968
83Abnormality of T cells (HP:0002843)2.54769041
84Inflammation of the large intestine (HP:0002037)2.54444694
85Vaginal fistula (HP:0004320)2.53378923
86Leukocytosis (HP:0001974)2.52438684
87Gastrointestinal inflammation (HP:0004386)2.51952282
88Abnormality of polysaccharide metabolism (HP:0011012)2.49262709
89Abnormality of glycosaminoglycan metabolism (HP:0004371)2.49262709
90Abnormality of mucopolysaccharide metabolism (HP:0011020)2.49262709
91Arterial thrombosis (HP:0004420)2.48360488
92Fatigue (HP:0012378)2.47090460
93Osteomyelitis (HP:0002754)2.44964495
94Keratoconjunctivitis (HP:0001096)2.43812511
95Amyloidosis (HP:0011034)2.43698838
96Increased IgM level (HP:0003496)2.43080352
97Partial duplication of thumb phalanx (HP:0009944)2.41506587
98Abnormality of the ileum (HP:0001549)2.41327194
99Aplasia/Hypoplasia of the uvula (HP:0010293)2.40353305
100Hyperinsulinemic hypoglycemia (HP:0000825)2.38052089
101Mucopolysacchariduria (HP:0008155)2.37563791
102Urinary glycosaminoglycan excretion (HP:0003541)2.37563791
103Skin tags (HP:0010609)2.35860833
104Epistaxis (HP:0000421)2.35793564
105Short 5th finger (HP:0009237)2.34718291
106Prolonged bleeding time (HP:0003010)2.32647887
107Glossoptosis (HP:0000162)2.31930943
108Anomalous pulmonary venous return (HP:0010772)2.31724623
109Progressive muscle weakness (HP:0003323)2.31386452
110Impulsivity (HP:0100710)2.30034934
111Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.29500584
112Increased serum ferritin (HP:0003281)2.27771378
113Bifid tongue (HP:0010297)2.27334506
114Cheilitis (HP:0100825)2.26487889
115Abnormality of the prostate (HP:0008775)2.24913443
116Abnormality of chromosome segregation (HP:0002916)2.19122934
117Abnormality of T cell physiology (HP:0011840)2.19032619
118Hand muscle atrophy (HP:0009130)2.18389332
119Horizontal nystagmus (HP:0000666)2.17989749
120Systemic lupus erythematosus (HP:0002725)2.17824063
121Gingival bleeding (HP:0000225)2.17403725
122Hypergammaglobulinemia (HP:0010702)2.16902511
123Large earlobe (HP:0009748)2.16735840
124Partial duplication of the phalanx of hand (HP:0009999)2.16711215
125Myelodysplasia (HP:0002863)2.15277239
126Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.14427142
127Upper motor neuron abnormality (HP:0002127)2.11955895
128Autoimmune hemolytic anemia (HP:0001890)2.11570969
129Amaurosis fugax (HP:0100576)2.11466351
130Peritonitis (HP:0002586)2.11101321
131Hematochezia (HP:0002573)2.10536207
132Viral hepatitis (HP:0006562)2.10482209
133Hepatosplenomegaly (HP:0001433)2.10418710
134Glioma (HP:0009733)2.10173621
135Microretrognathia (HP:0000308)2.09559094
136Aplasia/Hypoplasia of the 5th finger (HP:0006262)2.09515758
137Abnormality of the pleura (HP:0002103)2.08962045
138Aplastic anemia (HP:0001915)2.08805872
139Eosinophilia (HP:0001880)2.07336948
140Gangrene (HP:0100758)2.07079844
141Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.06268441
142Interstitial pulmonary disease (HP:0006530)2.05432392
143Medulloblastoma (HP:0002885)2.04528358
144Shawl scrotum (HP:0000049)2.03845250
145Pulmonary embolism (HP:0002204)2.03693048
146Atrophy/Degeneration involving motor neurons (HP:0007373)2.03556090
147Petechiae (HP:0000967)2.02886675
148Episodic fever (HP:0001954)2.02040883
149Pseudobulbar signs (HP:0002200)2.02030701
150Tongue fasciculations (HP:0001308)2.01899951
151Generalized hypotonia (HP:0001290)2.01703288
152Glomerulopathy (HP:0100820)2.01031418
153Duodenal stenosis (HP:0100867)2.00541581
154Small intestinal stenosis (HP:0012848)2.00541581
155Combined immunodeficiency (HP:0005387)2.00496010
156Abnormality of iron homeostasis (HP:0011031)2.00110496
157Renal duplication (HP:0000075)1.99294073
158Myocardial infarction (HP:0001658)1.98650385
159Increased connective tissue (HP:0009025)1.98635886
160Anorexia (HP:0002039)1.98170860
161Abnormality of the distal phalanx of the thumb (HP:0009617)1.98157358
162Supernumerary spleens (HP:0009799)1.97905017
163Selective tooth agenesis (HP:0001592)1.97566010
164Periauricular skin pits (HP:0100277)1.97145841
165Preauricular pit (HP:0004467)1.97145841
166Restrictive lung disease (HP:0002091)1.96816453
167Lymphopenia (HP:0001888)1.96788954
168Abnormality of the musculature of the hand (HP:0001421)1.96091816
169Spondylolisthesis (HP:0003302)1.95445008
170Ulnar bowing (HP:0003031)1.95273889
171Chronic diarrhea (HP:0002028)1.94948464
172Skin ulcer (HP:0200042)1.94365108
173Polyneuropathy (HP:0001271)1.93680069
174Sepsis (HP:0100806)1.93555042
175Vertebral fusion (HP:0002948)1.93325686
176Gastrointestinal stroma tumor (HP:0100723)1.93156035
177Abnormality of the fovea (HP:0000493)1.92496431
178Abnormality of the pulmonary veins (HP:0011718)1.92440536
179Missing ribs (HP:0000921)1.91902165
180Hypopigmentation of the fundus (HP:0007894)1.91891889
181Villous atrophy (HP:0011473)1.91555235
182Abnormality of small intestinal villus morphology (HP:0011472)1.91555235
183Gingivitis (HP:0000230)1.90729275
184Nasal polyposis (HP:0100582)1.88759843
185Pendular nystagmus (HP:0012043)1.84930676
186Premature ovarian failure (HP:0008209)1.84780453
187Abnormality of the phalanges of the hallux (HP:0010057)1.84517652
188Aplasia/Hypoplasia of the sternum (HP:0006714)1.83811254
189Resting tremor (HP:0002322)1.83320323
190Eczematoid dermatitis (HP:0000976)1.83211459
191Aplasia/Hypoplasia of the macula (HP:0008059)1.83140574
192Malignant neoplasm of the central nervous system (HP:0100836)1.82639011
193Muscle fibrillation (HP:0010546)1.82591626
194Angiofibromas (HP:0010615)1.81708301
195Adenoma sebaceum (HP:0009720)1.81708301
196Atresia of the external auditory canal (HP:0000413)1.80374099
197Absent frontal sinuses (HP:0002688)1.78046216

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK127.87315152
2ERN15.08867113
3GRK64.34570037
4GRK53.95731788
5RIPK43.57946027
6MAP3K142.93638747
7CSF1R2.93398230
8STK102.92765419
9TYK22.91794640
10MAP3K132.72636200
11PRPF4B2.70996434
12TTK2.54245322
13TGFBR22.46730041
14GRK12.42652513
15MATK2.17024882
16ADRBK22.13299011
17FES2.06133077
18JAK32.05085854
19TYRO32.01565216
20TBK11.97688072
21TAOK31.95167154
22IRAK31.92060051
23MOS1.90729346
24IKBKE1.77420146
25TXK1.76061369
26CDK71.74815539
27MAPK71.74203922
28PAK41.74041661
29SYK1.66013762
30PRKG21.59895028
31GRK71.59121582
32CSK1.40468988
33JAK11.39721284
34TNK21.39021910
35MAP3K101.38867618
36NEK21.34355769
37NME21.33025725
38CDC71.32913735
39LYN1.30575249
40BMPR21.30455268
41WNK11.30145299
42CHEK21.25509824
43TESK21.23505408
44TEC1.20188082
45PLK11.19336938
46WEE11.16856787
47LCK1.15417295
48EPHA21.13573000
49SMG11.09720265
50CAMK41.08036297
51JAK21.06115403
52ALK1.05750399
53MAP3K10.99345345
54CDC42BPA0.99229819
55FGFR30.99208638
56MARK30.97461694
57HIPK20.95319444
58BUB10.94890202
59SIK30.94013852
60IRAK10.93966253
61MARK20.90857621
62MAP2K60.88920945
63KSR20.88233917
64NTRK10.87693305
65CDK60.84477790
66MAP2K30.80151723
67CHEK10.79631300
68BLK0.76664907
69ADRBK10.74669759
70PDK10.74292270
71TRIB30.73813685
72IRAK40.73082517
73PIK3CG0.72593085
74RPS6KB20.70808489
75CDK40.69162163
76PRKD20.66383292
77CHUK0.65941570
78IRAK20.64932364
79PTK20.64239940
80MAP3K80.63637894
81PDPK10.62762171
82ITK0.62046399
83MAP2K40.61900473
84MAP3K90.61626669
85BRD40.61157085
86MAP4K10.59802175
87MTOR0.59660249
88NEK10.59174493
89AKT20.58842753
90NEK90.58100806
91MAPK110.55926485
92YES10.53795969
93FGFR40.52518949
94AURKA0.51708675
95AURKB0.51511181
96MAPKAPK30.51477664
97TTN0.51191204
98LRRK20.50954093
99HCK0.49783997
100ICK0.49082899
101CDK20.48915221
102PAK10.46333572
103TAOK10.46048880
104TAOK20.45351267
105RPS6KC10.45041735
106RPS6KL10.45041735
107DYRK30.44984752
108MAPK120.44519168
109MAP3K70.44234077
110MAP2K20.43888122
111EPHB10.43657865
112PIM10.43542343
113SIK10.42749714
114MAP3K50.42540006
115STK40.42318158
116LATS20.42078320
117RAF10.42048177
118EIF2AK20.41155817
119MELK0.41097296
120CAMKK20.40072009
121MAPK40.39618434
122BTK0.38712542
123ACVR1B0.38070531
124ZAP700.37745837
125FLT30.37330875
126BMX0.36800128
127MAP3K60.36391803
128PKN20.36389191
129PIM20.36256837
130MAP3K30.35603019
131CAMK1D0.35516829
132FYN0.35289831
133AKT30.35216375
134DYRK1B0.35126014
135PRKCD0.34834921
136PRKCQ0.34458084
137PRKCI0.34199231
138ATM0.33896045
139RPS6KA60.33820766
140CDK90.33300836
141ATR0.32198014
142RIPK10.32190667
143IGF1R0.31831885
144IKBKB0.29677069
145CLK10.28144436
146SCYL20.27470505
147EEF2K0.26772671
148BRSK20.25542434
149MAPKAPK20.25230879
150KDR0.24768460
151FGR0.24498928
152MAP3K110.23721142
153MAPK10.21758465
154KIT0.20888695
155PDGFRA0.19371453
156CDK10.19194719
157TRPM70.18844097

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007504.42099341
2Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006034.09279092
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.74171074
4Fructose and mannose metabolism_Homo sapiens_hsa000513.02317991
5Allograft rejection_Homo sapiens_hsa053302.90409845
6DNA replication_Homo sapiens_hsa030302.78904752
7Asthma_Homo sapiens_hsa053102.63670804
8Autoimmune thyroid disease_Homo sapiens_hsa053202.57601033
9Osteoclast differentiation_Homo sapiens_hsa043802.56589815
10Graft-versus-host disease_Homo sapiens_hsa053322.51204089
11Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.35219492
12Galactose metabolism_Homo sapiens_hsa000522.18975617
13Mismatch repair_Homo sapiens_hsa034302.08873218
14RNA transport_Homo sapiens_hsa030132.06553477
15Toll-like receptor signaling pathway_Homo sapiens_hsa046202.04613807
16Antigen processing and presentation_Homo sapiens_hsa046122.01543744
17Cell cycle_Homo sapiens_hsa041101.95067041
18One carbon pool by folate_Homo sapiens_hsa006701.90461876
19Arachidonic acid metabolism_Homo sapiens_hsa005901.85111789
20NOD-like receptor signaling pathway_Homo sapiens_hsa046211.84209833
21Type I diabetes mellitus_Homo sapiens_hsa049401.83532032
22Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.65493431
23Fanconi anemia pathway_Homo sapiens_hsa034601.64597292
24Measles_Homo sapiens_hsa051621.63973156
25Lysosome_Homo sapiens_hsa041421.63646013
26Rheumatoid arthritis_Homo sapiens_hsa053231.56538726
27Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.56019677
28Base excision repair_Homo sapiens_hsa034101.54023740
29Malaria_Homo sapiens_hsa051441.52907431
30mTOR signaling pathway_Homo sapiens_hsa041501.52600310
31Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.50497473
32Pentose phosphate pathway_Homo sapiens_hsa000301.48447082
33TNF signaling pathway_Homo sapiens_hsa046681.48134380
34Viral myocarditis_Homo sapiens_hsa054161.48004517
35Homologous recombination_Homo sapiens_hsa034401.47853496
36Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.45117732
37Pentose and glucuronate interconversions_Homo sapiens_hsa000401.44186636
38Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.42132134
39Thyroid cancer_Homo sapiens_hsa052161.41639368
40mRNA surveillance pathway_Homo sapiens_hsa030151.40416638
41p53 signaling pathway_Homo sapiens_hsa041151.36091169
42Spliceosome_Homo sapiens_hsa030401.33911089
43Leukocyte transendothelial migration_Homo sapiens_hsa046701.32606962
44Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.31342792
45Pertussis_Homo sapiens_hsa051331.29728494
46Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.29039422
47Leishmaniasis_Homo sapiens_hsa051401.27106016
48Transcriptional misregulation in cancer_Homo sapiens_hsa052021.26796154
49Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.23921086
50Phagosome_Homo sapiens_hsa041451.23443827
51Other glycan degradation_Homo sapiens_hsa005111.21708700
52Chemokine signaling pathway_Homo sapiens_hsa040621.21005958
53Ribosome_Homo sapiens_hsa030101.19917491
54Acute myeloid leukemia_Homo sapiens_hsa052211.14444632
55RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.12587112
56Glycosaminoglycan degradation_Homo sapiens_hsa005311.12111576
57Bladder cancer_Homo sapiens_hsa052191.08506315
58Linoleic acid metabolism_Homo sapiens_hsa005911.07365224
59alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.04847247
60African trypanosomiasis_Homo sapiens_hsa051431.04463304
61Hepatitis C_Homo sapiens_hsa051601.04400206
62MicroRNAs in cancer_Homo sapiens_hsa052061.03368146
63RNA degradation_Homo sapiens_hsa030181.02621920
64Herpes simplex infection_Homo sapiens_hsa051680.95597794
65Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.93235225
66Central carbon metabolism in cancer_Homo sapiens_hsa052300.92999494
67Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.92950171
68Regulation of actin cytoskeleton_Homo sapiens_hsa048100.87123871
69Epstein-Barr virus infection_Homo sapiens_hsa051690.86764858
70Non-small cell lung cancer_Homo sapiens_hsa052230.86176358
71Platelet activation_Homo sapiens_hsa046110.85610757
72Salmonella infection_Homo sapiens_hsa051320.85172756
73Sulfur relay system_Homo sapiens_hsa041220.84686293
74Folate biosynthesis_Homo sapiens_hsa007900.81195475
75Apoptosis_Homo sapiens_hsa042100.77525037
76Pathways in cancer_Homo sapiens_hsa052000.77333831
77Nucleotide excision repair_Homo sapiens_hsa034200.76237672
78Pancreatic cancer_Homo sapiens_hsa052120.75201622
79Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.73378243
80B cell receptor signaling pathway_Homo sapiens_hsa046620.72993294
81AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.71711391
82Viral carcinogenesis_Homo sapiens_hsa052030.70405528
83VEGF signaling pathway_Homo sapiens_hsa043700.70266933
84Inositol phosphate metabolism_Homo sapiens_hsa005620.69836339
85Prolactin signaling pathway_Homo sapiens_hsa049170.66822767
86NF-kappa B signaling pathway_Homo sapiens_hsa040640.66648023
87Biosynthesis of amino acids_Homo sapiens_hsa012300.65571908
88Phospholipase D signaling pathway_Homo sapiens_hsa040720.64882067
89Proteoglycans in cancer_Homo sapiens_hsa052050.63876371
90HTLV-I infection_Homo sapiens_hsa051660.60563572
91Amoebiasis_Homo sapiens_hsa051460.59828883
92Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.59800509
93Small cell lung cancer_Homo sapiens_hsa052220.59469560
94Sphingolipid signaling pathway_Homo sapiens_hsa040710.58961846
95Rap1 signaling pathway_Homo sapiens_hsa040150.58716334
96Pyrimidine metabolism_Homo sapiens_hsa002400.58404963
97Non-homologous end-joining_Homo sapiens_hsa034500.58154298
98Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.55251594
99SNARE interactions in vesicular transport_Homo sapiens_hsa041300.54674612
100Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.54247110
101Adipocytokine signaling pathway_Homo sapiens_hsa049200.53872090
102Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.53628502
103Notch signaling pathway_Homo sapiens_hsa043300.52589170
104Neurotrophin signaling pathway_Homo sapiens_hsa047220.52328282
105Legionellosis_Homo sapiens_hsa051340.52200613
106Hematopoietic cell lineage_Homo sapiens_hsa046400.52126242
107Primary immunodeficiency_Homo sapiens_hsa053400.51513129
108Renal cell carcinoma_Homo sapiens_hsa052110.51175694
109RNA polymerase_Homo sapiens_hsa030200.51169332
110Colorectal cancer_Homo sapiens_hsa052100.50634476
111Shigellosis_Homo sapiens_hsa051310.50346060
112Chemical carcinogenesis_Homo sapiens_hsa052040.47683023
113Selenocompound metabolism_Homo sapiens_hsa004500.47076503
114Thyroid hormone signaling pathway_Homo sapiens_hsa049190.46032180
115Adherens junction_Homo sapiens_hsa045200.45994960
116Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.45761903
117Systemic lupus erythematosus_Homo sapiens_hsa053220.44724247
118HIF-1 signaling pathway_Homo sapiens_hsa040660.44404111
119Basal transcription factors_Homo sapiens_hsa030220.43456589
120Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.42709424
121Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.42138531
122Cyanoamino acid metabolism_Homo sapiens_hsa004600.42094227
123Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.41897566
124Ovarian steroidogenesis_Homo sapiens_hsa049130.41259764
125Prostate cancer_Homo sapiens_hsa052150.40389003
126FoxO signaling pathway_Homo sapiens_hsa040680.39343788
127Endocytosis_Homo sapiens_hsa041440.38144477
128AMPK signaling pathway_Homo sapiens_hsa041520.38028529
129Phosphatidylinositol signaling system_Homo sapiens_hsa040700.37314355
130Chronic myeloid leukemia_Homo sapiens_hsa052200.36998821
131Choline metabolism in cancer_Homo sapiens_hsa052310.36284402
132Dorso-ventral axis formation_Homo sapiens_hsa043200.36175782
133Basal cell carcinoma_Homo sapiens_hsa052170.35860446
134Jak-STAT signaling pathway_Homo sapiens_hsa046300.35338402
135T cell receptor signaling pathway_Homo sapiens_hsa046600.34919113
136Staphylococcus aureus infection_Homo sapiens_hsa051500.34362322
137Influenza A_Homo sapiens_hsa051640.33669061
138Hepatitis B_Homo sapiens_hsa051610.33379166
139Insulin resistance_Homo sapiens_hsa049310.32445933
140Toxoplasmosis_Homo sapiens_hsa051450.32157825
141Tuberculosis_Homo sapiens_hsa051520.31588627
142Endometrial cancer_Homo sapiens_hsa052130.31581846
143Hippo signaling pathway_Homo sapiens_hsa043900.31397803
144Intestinal immune network for IgA production_Homo sapiens_hsa046720.30633764
145Glycerophospholipid metabolism_Homo sapiens_hsa005640.30084168
146Renin-angiotensin system_Homo sapiens_hsa046140.26753147
147Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.24475806
148Sphingolipid metabolism_Homo sapiens_hsa006000.24330722

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