ADORA2B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an adenosine receptor that is a member of the G protein-coupled receptor superfamily. This integral membrane protein stimulates adenylate cyclase activity in the presence of adenosine. This protein also interacts with netrin-1, which is involved in axon elongation. The gene is located near the Smith-Magenis syndrome region on chromosome 17. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1modulation by organism of immune response of other organism involved in symbiotic interaction (GO:006.15549297
2modulation by organism of defense response of other organism involved in symbiotic interaction (GO:06.15549297
3positive regulation by organism of defense response of other organism involved in symbiotic interact6.15549297
4modulation by symbiont of host immune response (GO:0052553)6.15549297
5positive regulation by symbiont of host defense response (GO:0052509)6.15549297
6modulation by symbiont of host defense response (GO:0052031)6.15549297
7positive regulation of cellular amide metabolic process (GO:0034250)5.33692929
8response to peptidoglycan (GO:0032494)5.12508556
9protein maturation by protein folding (GO:0022417)5.09396550
10hemidesmosome assembly (GO:0031581)4.71689102
11neutrophil activation involved in immune response (GO:0002283)4.66322832
12positive regulation of chemokine biosynthetic process (GO:0045080)4.55806136
13positive regulation of membrane protein ectodomain proteolysis (GO:0051044)4.46944320
14macrophage activation involved in immune response (GO:0002281)4.25697413
15positive regulation of heat generation (GO:0031652)4.21347819
16Golgi transport vesicle coating (GO:0048200)4.13726695
17COPI coating of Golgi vesicle (GO:0048205)4.13726695
18eosinophil chemotaxis (GO:0048245)4.11135713
19lipopolysaccharide-mediated signaling pathway (GO:0031663)3.98417684
20eosinophil migration (GO:0072677)3.94009596
21establishment of integrated proviral latency (GO:0075713)3.90790013
22nucleobase-containing small molecule interconversion (GO:0015949)3.87449081
23hydrogen peroxide biosynthetic process (GO:0050665)3.86373774
24respiratory burst (GO:0045730)3.85114062
25leukocyte aggregation (GO:0070486)3.84646355
26response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.84306422
27response to host immune response (GO:0052572)3.84306422
28ribosome assembly (GO:0042255)3.82623011
29skin morphogenesis (GO:0043589)3.81320161
30positive regulation of toll-like receptor signaling pathway (GO:0034123)3.80148480
31proteasome assembly (GO:0043248)3.78250807
32antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.76133782
33nuclear envelope reassembly (GO:0031468)3.75045480
34mitotic nuclear envelope reassembly (GO:0007084)3.75045480
35immunoglobulin mediated immune response (GO:0016064)3.69582058
36regulation of dendritic cell antigen processing and presentation (GO:0002604)3.69113920
37regulation of membrane protein ectodomain proteolysis (GO:0051043)3.68239179
38microglial cell activation (GO:0001774)3.67341067
39regulation of fever generation (GO:0031620)3.58793963
40positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.58518767
41protein localization to endosome (GO:0036010)3.56061093
42positive regulation of interferon-alpha production (GO:0032727)3.55320148
43positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.53820765
44mesodermal cell differentiation (GO:0048333)3.53008737
45granulocyte activation (GO:0036230)3.52714434
46regulation of interferon-beta biosynthetic process (GO:0045357)3.52221517
47* positive regulation of mast cell activation involved in immune response (GO:0033008)3.51909609
48* positive regulation of mast cell degranulation (GO:0043306)3.51909609
49neutrophil activation (GO:0042119)3.46941215
50establishment of viral latency (GO:0019043)3.46333565
51regulation of heat generation (GO:0031650)3.46280047
52regulation of mononuclear cell migration (GO:0071675)3.45816593
53cellular extravasation (GO:0045123)3.45427728
54response to muramyl dipeptide (GO:0032495)3.44108032
55positive regulation of mitochondrial calcium ion concentration (GO:0051561)3.42800842
56regulation of interferon-alpha production (GO:0032647)3.42542252
57response to host (GO:0075136)3.37855000
58response to host defenses (GO:0052200)3.37855000
59response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.37855000
60regulation of chemokine biosynthetic process (GO:0045073)3.32588724
61production of molecular mediator involved in inflammatory response (GO:0002532)3.31794435
62reactive oxygen species biosynthetic process (GO:1903409)3.31584809
63deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.30516067
64cytokine secretion (GO:0050663)3.30371328
65regulation of podosome assembly (GO:0071801)3.26736425
66positive regulation of actin filament depolymerization (GO:0030836)3.25284523
67negative regulation of release of cytochrome c from mitochondria (GO:0090201)3.25073873
68macrophage activation (GO:0042116)3.23748192
69membrane raft organization (GO:0031579)3.23273128
70positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.23105222
71negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.22965553
72interferon-gamma-mediated signaling pathway (GO:0060333)3.22532866
73negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)3.22224436
74hypotonic response (GO:0006971)3.21545996
75positive regulation of NF-kappaB import into nucleus (GO:0042346)3.21533788
76* positive regulation of mast cell activation (GO:0033005)3.19715078
77positive regulation of interferon-beta production (GO:0032728)3.16534824
78positive regulation of monocyte chemotaxis (GO:0090026)3.14583069
79regulation of metalloenzyme activity (GO:0048552)3.14290252
80detection of molecule of bacterial origin (GO:0032490)3.10542603
81positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.08127592
82negative regulation of interleukin-12 production (GO:0032695)3.07745527
83deoxyribonucleotide biosynthetic process (GO:0009263)3.04271547
84desmosome organization (GO:0002934)3.03903701
85myeloid cell activation involved in immune response (GO:0002275)3.03095981
86nucleoside salvage (GO:0043174)3.02327790
87apoptotic cell clearance (GO:0043277)3.01398787
88maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.98412094
89positive regulation of antigen processing and presentation (GO:0002579)2.96897330
90mitotic metaphase plate congression (GO:0007080)2.95362291
91superoxide anion generation (GO:0042554)2.94679534
92positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.94427558
93cellular copper ion homeostasis (GO:0006878)2.93787285
94* regulation of mast cell degranulation (GO:0043304)2.93446401
95positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.91581574
96monocyte chemotaxis (GO:0002548)2.89716816
97protein hydroxylation (GO:0018126)2.89232487
98regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.88821464
99lipopolysaccharide biosynthetic process (GO:0009103)2.88440193
100barbed-end actin filament capping (GO:0051016)2.86680641
101protein retention in ER lumen (GO:0006621)2.86306034
102pentose-phosphate shunt (GO:0006098)2.86151091
103cellular response to type I interferon (GO:0071357)2.83517926
104type I interferon signaling pathway (GO:0060337)2.83517926
105negative regulation of myeloid cell apoptotic process (GO:0033033)2.83418885
106regulation of vitamin D biosynthetic process (GO:0060556)2.82798769
107* positive regulation of leukocyte degranulation (GO:0043302)2.82776363
108antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.82629947
109antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.82629947
110negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.80880395
111AMP metabolic process (GO:0046033)2.80775455
112response to type I interferon (GO:0034340)2.80735373
113regulation of monocyte chemotaxis (GO:0090025)2.78648575
114* positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.77983342
115negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.77648539
116negative regulation of ligase activity (GO:0051352)2.77648539
117T-helper 1 type immune response (GO:0042088)2.76499377
118mitotic chromosome condensation (GO:0007076)2.75924269
119anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.74917413
120regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.74480830
121regulation of antigen processing and presentation (GO:0002577)2.74244327
122I-kappaB phosphorylation (GO:0007252)2.74038375
123* regulation of mast cell activation involved in immune response (GO:0033006)2.72719836
124* positive regulation of chemokine production (GO:0032722)2.72674218
125* positive regulation of interleukin-6 production (GO:0032755)2.71184031
126natural killer cell mediated immunity (GO:0002228)2.70551569
127natural killer cell mediated cytotoxicity (GO:0042267)2.70551569
128metaphase plate congression (GO:0051310)2.70355119
129glucose catabolic process (GO:0006007)2.70162489
130regulation of heterotypic cell-cell adhesion (GO:0034114)2.70111582
131regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.70102924
132* regulation of leukocyte degranulation (GO:0043300)2.67938859
133regulation of mitotic spindle organization (GO:0060236)2.67630528
134granulocyte chemotaxis (GO:0071621)2.67397505
135wound healing, spreading of epidermal cells (GO:0035313)2.67282032
136peptidyl-proline hydroxylation (GO:0019511)2.67252050
137leukocyte mediated cytotoxicity (GO:0001909)2.66448983
138NADPH regeneration (GO:0006740)2.66209945
139cell adhesion mediated by integrin (GO:0033627)2.65734630
140* regulation of myeloid leukocyte mediated immunity (GO:0002886)2.65209828
141regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.65179366
142leukocyte cell-cell adhesion (GO:0007159)2.65151182
143positive regulation of p38MAPK cascade (GO:1900745)2.64354940
144neutrophil chemotaxis (GO:0030593)2.63801154
145substrate-dependent cell migration (GO:0006929)2.63534819
146mitotic sister chromatid segregation (GO:0000070)2.63401281
147ribosomal large subunit biogenesis (GO:0042273)2.63330603
148positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.63058702
149regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.62576061
150muscle cell migration (GO:0014812)2.61789440
151positive regulation of macrophage cytokine production (GO:0060907)2.60817024
152B cell mediated immunity (GO:0019724)2.60759679
153de novo protein folding (GO:0006458)2.60337034
154cell-substrate junction assembly (GO:0007044)2.59276612
155regulation of superoxide anion generation (GO:0032928)2.57931593
156regulation of spindle organization (GO:0090224)2.57472890
157protein heterotetramerization (GO:0051290)2.55019034
158negative regulation of mitochondrion organization (GO:0010823)2.54981140
159DNA unwinding involved in DNA replication (GO:0006268)2.54974027
160regulation of epidermal growth factor-activated receptor activity (GO:0007176)2.53612799
161extracellular fibril organization (GO:0043206)2.53003503
162dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.52137802
163regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.51901172
164negative regulation of homotypic cell-cell adhesion (GO:0034111)2.51459572
165regulation of transforming growth factor beta2 production (GO:0032909)2.51150132
166pyrimidine nucleoside salvage (GO:0043097)2.50457906
167pyrimidine-containing compound salvage (GO:0008655)2.50457906
168deoxyribose phosphate biosynthetic process (GO:0046385)2.49545531
1692-deoxyribonucleotide biosynthetic process (GO:0009265)2.49545531
170regulation of exit from mitosis (GO:0007096)2.49506916
171pinocytosis (GO:0006907)2.48860259
172protein localization to chromosome, centromeric region (GO:0071459)2.48706934
173cellular response to arsenic-containing substance (GO:0071243)2.48290460
174regulation of translational termination (GO:0006449)2.47030703
175proline biosynthetic process (GO:0006561)2.46510375
176negative regulation of anoikis (GO:2000811)2.45247723
177establishment of chromosome localization (GO:0051303)2.43905349
178regulation of cellular amino acid metabolic process (GO:0006521)2.42632705
179nucleotide-sugar biosynthetic process (GO:0009226)2.41727162
180de novo posttranslational protein folding (GO:0051084)2.41657917
181ventricular cardiac muscle cell development (GO:0055015)2.40119479
182telomere maintenance via semi-conservative replication (GO:0032201)2.39369436
183type B pancreatic cell proliferation (GO:0044342)2.36386915
184regulation of integrin-mediated signaling pathway (GO:2001044)2.36360961
185negative regulation of hydrogen peroxide-induced cell death (GO:1903206)2.34929428
186hepatocyte differentiation (GO:0070365)2.34648493
187negative regulation of chondrocyte differentiation (GO:0032331)2.33619710
188cellular protein complex localization (GO:0034629)2.32171721
189positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.29623801
190cyclooxygenase pathway (GO:0019371)2.27691179
191UDP-N-acetylglucosamine metabolic process (GO:0006047)2.26247870
192folic acid-containing compound biosynthetic process (GO:0009396)2.24794443
193lipopolysaccharide metabolic process (GO:0008653)2.24101233
194guanosine-containing compound biosynthetic process (GO:1901070)2.23578333
195protein localization to kinetochore (GO:0034501)2.22603936
196protein localization to microtubule (GO:0035372)2.22494546

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human5.53666038
2IRF8_21731497_ChIP-ChIP_J774_Mouse5.13211893
3IRF8_22096565_ChIP-ChIP_GC-B_Human4.65115690
4BP1_19119308_ChIP-ChIP_Hs578T_Human4.35162963
5IRF8_27001747_Chip-Seq_BMDM_Mouse3.72426086
6* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.58032804
7Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.40152174
8EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.36334768
9E2F7_22180533_ChIP-Seq_HELA_Human3.35968399
10TRIM28_21343339_ChIP-Seq_HEK293_Human3.28044690
11RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.27203229
12* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.17415356
13FOXM1_23109430_ChIP-Seq_U2OS_Human3.00079195
14TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.99834702
15IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.90797213
16FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.73971387
17* MYB_21317192_ChIP-Seq_ERMYB_Mouse2.72092311
18MYC_18555785_ChIP-Seq_MESCs_Mouse2.68563323
19AR_21909140_ChIP-Seq_LNCAP_Human2.60786977
20NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.59320233
21MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.54913554
22ZNF263_19887448_ChIP-Seq_K562_Human2.51974361
23STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.50210971
24IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.47490028
25KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.40435564
26EGR1_19374776_ChIP-ChIP_THP-1_Human2.40431642
27MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.29268581
28NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.27064154
29NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.21138862
30DCP1A_22483619_ChIP-Seq_HELA_Human2.20756259
31HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.19735658
32* STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.17345787
33* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.15242793
34DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.14129794
35FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.12817811
36JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.12175002
37NELFA_20434984_ChIP-Seq_ESCs_Mouse2.10387527
38MYC_19030024_ChIP-ChIP_MESCs_Mouse1.98496838
39CREB1_15753290_ChIP-ChIP_HEK293T_Human1.96413573
40TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.92377599
41E2F1_18555785_ChIP-Seq_MESCs_Mouse1.90202595
42HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.86442922
43RARG_19884340_ChIP-ChIP_MEFs_Mouse1.85885274
44VDR_24787735_ChIP-Seq_THP-1_Human1.82359953
45GABP_17652178_ChIP-ChIP_JURKAT_Human1.80710280
46STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.80599803
47STAT4_19710469_ChIP-ChIP_TH1__Mouse1.80458251
48* THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.79502230
49THAP11_20581084_ChIP-Seq_MESCs_Mouse1.76862662
50MYC_19079543_ChIP-ChIP_MESCs_Mouse1.76430305
51SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.75891355
52CDX2_19796622_ChIP-Seq_MESCs_Mouse1.74293658
53ATF3_27146783_Chip-Seq_COLON_Human1.72837607
54KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.67419764
55ZFX_18555785_ChIP-Seq_MESCs_Mouse1.66177569
56RUNX_20019798_ChIP-Seq_JUKART_Human1.64519579
57PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.63961917
58TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.63526052
59* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.62631001
60PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.62126496
61E2F4_17652178_ChIP-ChIP_JURKAT_Human1.60408317
62ETS1_20019798_ChIP-Seq_JURKAT_Human1.59888664
63VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.59168860
64ELK1_19687146_ChIP-ChIP_HELA_Human1.58579844
65KLF4_18555785_ChIP-Seq_MESCs_Mouse1.57317567
66MYCN_18555785_ChIP-Seq_MESCs_Mouse1.55656828
67TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.51989346
68IKZF1_21737484_ChIP-ChIP_HCT116_Human1.51515399
69ESR2_21235772_ChIP-Seq_MCF-7_Human1.50838495
70VDR_24763502_ChIP-Seq_THP-1_Human1.50628931
71ELF1_17652178_ChIP-ChIP_JURKAT_Human1.50172944
72* PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.50008045
73* SMAD_19615063_ChIP-ChIP_OVARY_Human1.49617527
74SPI1_23127762_ChIP-Seq_K562_Human1.49236111
75TFEB_21752829_ChIP-Seq_HELA_Human1.48307706
76* CJUN_26792858_Chip-Seq_BT549_Human1.47085460
77SOX2_20726797_ChIP-Seq_SW620_Human1.45753536
78HIF1A_21447827_ChIP-Seq_MCF-7_Human1.45671040
79ESR1_21235772_ChIP-Seq_MCF-7_Human1.45465683
80CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.44576147
81POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.43771764
82NANOG_18555785_ChIP-Seq_MESCs_Mouse1.42119809
83GABP_19822575_ChIP-Seq_HepG2_Human1.42062335
84* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.40978613
85XRN2_22483619_ChIP-Seq_HELA_Human1.40755731
86GATA1_22025678_ChIP-Seq_K562_Human1.38838889
87* PU_27001747_Chip-Seq_BMDM_Mouse1.37251518
88NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.36606001
89NRF2_20460467_ChIP-Seq_MEFs_Mouse1.36606001
90EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.36488148
91GATA2_21666600_ChIP-Seq_HMVEC_Human1.36169562
92CLOCK_20551151_ChIP-Seq_293T_Human1.34986042
93PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.34944322
94* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.34596885
95SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.32229188
96CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.31005267
97KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.30955744
98* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.30741113
99SPI1_23547873_ChIP-Seq_NB4_Human1.29516624
100* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.28606771
101SRF_21415370_ChIP-Seq_HL-1_Mouse1.27109054
102FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.26734225
103CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.26031037
104STAT3_1855785_ChIP-Seq_MESCs_Mouse1.25336557
105FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.23004587
106CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.22599098
107* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.22319207
108EST1_17652178_ChIP-ChIP_JURKAT_Human1.21579441
109NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.20980849
110ERG_20887958_ChIP-Seq_HPC-7_Mouse1.20593199
111SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.20385709
112SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.20385709
113* TP53_18474530_ChIP-ChIP_U2OS_Human1.20284448
114SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.19575889
115* PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.19219050
116TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.17695451
117ELK1_22589737_ChIP-Seq_MCF10A_Human1.17513466
118CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.16576518
119BRD4_25478319_ChIP-Seq_HGPS_Human1.16561879
120HOXB4_20404135_ChIP-ChIP_EML_Mouse1.16386269
121SCL_19346495_ChIP-Seq_HPC-7_Human1.16288405
122POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.16225913
123MYB_26560356_Chip-Seq_TH2_Human1.15196930
124FOXO3_23340844_ChIP-Seq_DLD1_Human1.13730286
125CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.13324022
126* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.12642037
127* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.11874153
128MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.11777475
129SRY_22984422_ChIP-ChIP_TESTIS_Rat1.11718782
130TTF2_22483619_ChIP-Seq_HELA_Human1.10551989
131TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.10055003
132SOX17_20123909_ChIP-Seq_XEN_Mouse1.09821647
133ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.08299773
134RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.08218979
135RXR_22108803_ChIP-Seq_LS180_Human1.07904241
136TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse1.05083471
137PPAR_26484153_Chip-Seq_NCI-H1993_Human1.04635264
138BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.03865512
139* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.03190617
140DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.02200888
141PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.02012713
142CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.01658070
143E2F1_21310950_ChIP-Seq_MCF-7_Human1.00749957
144SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.00304130
145ELK3_25401928_ChIP-Seq_HUVEC_Human1.00011562
146GATA3_27048872_Chip-Seq_THYMUS_Human0.99097272
147* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.98832764
148* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.98308132
149RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.98095899
150SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.97495210
151MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.97346909
152ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.96015031
153MAF_26560356_Chip-Seq_TH1_Human0.95958240
154* RUNX1_22412390_ChIP-Seq_EML_Mouse0.95717248
155TP63_23658742_ChIP-Seq_EP156T_Human0.94162404
156SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93628974
157ZNF217_24962896_ChIP-Seq_MCF-7_Human0.93004083
158RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.92499445
159KDM2B_26808549_Chip-Seq_SUP-B15_Human0.91635492
160* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.90313159
161ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.87917893
162TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.86674969
163* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.86265137
164FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.86071787
165SOX9_24532713_ChIP-Seq_HFSC_Mouse0.85965041
166KLF5_25053715_ChIP-Seq_YYC3_Human0.84763450
167E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.82371700
168UBF1/2_26484160_Chip-Seq_HMECs_Human0.81859367
169ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.80499820
170GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.80423138
171CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.79341043
172WT1_19549856_ChIP-ChIP_CCG9911_Human0.78355862
173SALL4_18804426_ChIP-ChIP_XEN_Mouse0.77384016

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003436_decreased_susceptibility_to3.96465539
2MP0003303_peritoneal_inflammation3.79192409
3* MP0002148_abnormal_hypersensitivity_rea3.10119830
4MP0009785_altered_susceptibility_to3.09232843
5MP0004272_abnormal_basement_membrane3.05628783
6MP0002419_abnormal_innate_immunity3.04189020
7MP0001835_abnormal_antigen_presentation2.96773007
8MP0005167_abnormal_blood-brain_barrier2.83757331
9MP0005000_abnormal_immune_tolerance2.82839570
10MP0002254_reproductive_system_inflammat2.79559007
11MP0003806_abnormal_nucleotide_metabolis2.74439898
12MP0003724_increased_susceptibility_to2.60306163
13MP0005025_abnormal_response_to2.41581226
14MP0001533_abnormal_skeleton_physiology2.39225436
15MP0005058_abnormal_lysosome_morphology2.29360605
16MP0001790_abnormal_immune_system2.25387885
17MP0005387_immune_system_phenotype2.25387885
18MP0005623_abnormal_meninges_morphology2.23426770
19MP0003075_altered_response_to2.19327851
20MP0009764_decreased_sensitivity_to2.12196594
21MP0003183_abnormal_peptide_metabolism2.09614426
22MP0009840_abnormal_foam_cell2.09324775
23* MP0002452_abnormal_antigen_presenting2.08615457
24MP0004947_skin_inflammation2.03640575
25MP0001853_heart_inflammation2.03369494
26MP0003690_abnormal_glial_cell2.00990146
27MP0008007_abnormal_cellular_replicative1.99236391
28MP0010234_abnormal_vibrissa_follicle1.98639265
29MP0004858_abnormal_nervous_system1.97133785
30* MP0000343_altered_response_to1.96682168
31MP0005464_abnormal_platelet_physiology1.94395865
32MP0004782_abnormal_surfactant_physiolog1.93768132
33MP0005671_abnormal_response_to1.93358518
34MP0003448_altered_tumor_morphology1.92987589
35MP0005451_abnormal_body_composition1.91524447
36* MP0002723_abnormal_immune_serum1.88344829
37MP0006082_CNS_inflammation1.87706792
38MP0005501_abnormal_skin_physiology1.85852076
39MP0008932_abnormal_embryonic_tissue1.83742297
40MP0004957_abnormal_blastocyst_morpholog1.82615201
41MP0002405_respiratory_system_inflammati1.82514042
42MP0006054_spinal_hemorrhage1.81863944
43MP0003111_abnormal_nucleus_morphology1.77696043
44MP0000685_abnormal_immune_system1.77082027
45MP0001800_abnormal_humoral_immune1.72922785
46MP0000604_amyloidosis1.69796958
47MP0000858_altered_metastatic_potential1.68797685
48MP0003077_abnormal_cell_cycle1.68257874
49* MP0001819_abnormal_immune_cell1.67670323
50* MP0002420_abnormal_adaptive_immunity1.67143630
51MP0002998_abnormal_bone_remodeling1.66563539
52MP0009278_abnormal_bone_marrow1.63749628
53* MP0001845_abnormal_inflammatory_respons1.62725888
54MP0003172_abnormal_lysosome_physiology1.59899961
55MP0004510_myositis1.57329719
56MP0003656_abnormal_erythrocyte_physiolo1.55389610
57MP0001958_emphysema1.53755695
58MP0000358_abnormal_cell_content/1.52536753
59MP0000762_abnormal_tongue_morphology1.47150307
60MP0003300_gastrointestinal_ulcer1.46749380
61MP0003693_abnormal_embryo_hatching1.46443538
62MP0003566_abnormal_cell_adhesion1.46270413
63MP0008260_abnormal_autophagy1.43300617
64MP0005390_skeleton_phenotype1.42791674
65MP0010094_abnormal_chromosome_stability1.41989763
66MP0005166_decreased_susceptibility_to1.40153490
67MP0003786_premature_aging1.36408493
68MP0003279_aneurysm1.35914300
69* MP0005164_abnormal_response_to1.35856622
70MP0005076_abnormal_cell_differentiation1.32857824
71MP0001849_ear_inflammation1.31406522
72MP0010155_abnormal_intestine_physiology1.31221786
73MP0002277_abnormal_respiratory_mucosa1.27880470
74MP0005310_abnormal_salivary_gland1.27711873
75MP0002796_impaired_skin_barrier1.27322610
76MP0009053_abnormal_anal_canal1.26773319
77* MP0008469_abnormal_protein_level1.25367083
78MP0008438_abnormal_cutaneous_collagen1.24791262
79MP0005257_abnormal_intraocular_pressure1.24430472
80MP0003941_abnormal_skin_development1.24133371
81MP0000537_abnormal_urethra_morphology1.23608666
82MP0010678_abnormal_skin_adnexa1.22280336
83MP0003646_muscle_fatigue1.21875402
84MP0010368_abnormal_lymphatic_system1.21838967
85MP0003453_abnormal_keratinocyte_physiol1.20822241
86MP0003091_abnormal_cell_migration1.20119366
87MP0010771_integument_phenotype1.19469686
88MP0004233_abnormal_muscle_weight1.19196315
89MP0000579_abnormal_nail_morphology1.16469501
90MP0005621_abnormal_cell_physiology1.15784882
91MP0003191_abnormal_cellular_cholesterol1.15217367
92MP0010030_abnormal_orbit_morphology1.12638238
93MP0003705_abnormal_hypodermis_morpholog1.12381989
94MP0000350_abnormal_cell_proliferation1.11408829
95MP0002234_abnormal_pharynx_morphology1.11230746
96MP0009780_abnormal_chondrocyte_physiolo1.10237468
97MP0003136_yellow_coat_color1.09757408
98MP0003950_abnormal_plasma_membrane1.09429549
99MP0000767_abnormal_smooth_muscle1.08129079
100MP0005023_abnormal_wound_healing1.07759061
101MP0005384_cellular_phenotype1.04654718
102MP0001851_eye_inflammation1.04552664
103MP0002295_abnormal_pulmonary_circulatio1.03600794
104MP0000465_gastrointestinal_hemorrhage1.02988411
105MP0002006_tumorigenesis1.02004974
106MP0003221_abnormal_cardiomyocyte_apopto1.00062015
107MP0000467_abnormal_esophagus_morphology0.99448450
108MP0001730_embryonic_growth_arrest0.99114433
109MP0003828_pulmonary_edema0.98927450
110MP0005083_abnormal_biliary_tract0.98241147
111MP0003718_maternal_effect0.97684903
112MP0000647_abnormal_sebaceous_gland0.96986589
113MP0002933_joint_inflammation0.96402829
114MP0000716_abnormal_immune_system0.95604378
115* MP0000249_abnormal_blood_vessel0.93730873
116MP0003795_abnormal_bone_structure0.93420104
117MP0008058_abnormal_DNA_repair0.92559030
118MP0002080_prenatal_lethality0.92385212
119MP0001243_abnormal_dermal_layer0.92090810
120MP0000490_abnormal_crypts_of0.88112734
121MP0001346_abnormal_lacrimal_gland0.87829067
122MP0001915_intracranial_hemorrhage0.87321788
123MP0001542_abnormal_bone_strength0.86032281
124MP0009333_abnormal_splenocyte_physiolog0.85260140
125MP0000678_abnormal_parathyroid_gland0.84485745
126MP0000749_muscle_degeneration0.84043909
127MP0005397_hematopoietic_system_phenotyp0.83178525
128MP0001545_abnormal_hematopoietic_system0.83178525
129MP0002086_abnormal_extraembryonic_tissu0.83072976
130MP0005193_abnormal_anterior_eye0.82908129
131MP0008004_abnormal_stomach_pH0.82347397
132MP0003186_abnormal_redox_activity0.82304619
133MP0001879_abnormal_lymphatic_vessel0.81671018
134MP0001697_abnormal_embryo_size0.78589215
135MP0000371_diluted_coat_color0.76923491
136MP0004883_abnormal_blood_vessel0.76500570
137MP0001216_abnormal_epidermal_layer0.75092852
138MP0003011_delayed_dark_adaptation0.74771393
139MP0000613_abnormal_salivary_gland0.74445713
140MP0009384_cardiac_valve_regurgitation0.74435709
141MP0000313_abnormal_cell_death0.73402750
142MP0005275_abnormal_skin_tensile0.73057937
143MP0002398_abnormal_bone_marrow0.72717721
144MP0002098_abnormal_vibrissa_morphology0.72670847
145MP0002332_abnormal_exercise_endurance0.72626571
146MP0000750_abnormal_muscle_regeneration0.72120771
147MP0005330_cardiomyopathy0.71934117
148MP0010307_abnormal_tumor_latency0.70990727
149MP0002896_abnormal_bone_mineralization0.70740618
150MP0001191_abnormal_skin_condition0.70594381
151MP0005379_endocrine/exocrine_gland_phen0.70276772
152MP0000627_abnormal_mammary_gland0.70266702
153MP0001672_abnormal_embryogenesis/_devel0.70028695
154MP0005380_embryogenesis_phenotype0.70028695
155MP0004185_abnormal_adipocyte_glucose0.69739311
156MP0010352_gastrointestinal_tract_polyps0.68687835
157MP0003315_abnormal_perineum_morphology0.67726944
158MP0002429_abnormal_blood_cell0.67566377
159MP0003634_abnormal_glial_cell0.66729241
160MP0002877_abnormal_melanocyte_morpholog0.66574213
161MP0005197_abnormal_uvea_morphology0.65892536
162MP0001727_abnormal_embryo_implantation0.65625028
163MP0002060_abnormal_skin_morphology0.65615187
164MP0005165_increased_susceptibility_to0.65481359
165MP0000383_abnormal_hair_follicle0.64842350
166MP0010386_abnormal_urinary_bladder0.64452865

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)5.73436767
2Eczematoid dermatitis (HP:0000976)5.59988237
3Recurrent bacterial skin infections (HP:0005406)4.82659539
4Premature rupture of membranes (HP:0001788)4.68815091
5Abnormality of macrophages (HP:0004311)4.66704875
6Recurrent gram-negative bacterial infections (HP:0005420)4.51579420
7Increased cerebral lipofuscin (HP:0011813)4.39562071
8Mediastinal lymphadenopathy (HP:0100721)4.37535049
9Increased neuronal autofluorescent lipopigment (HP:0002074)4.13901474
10Short nail (HP:0001799)3.99630288
11Stomatitis (HP:0010280)3.93952677
12Orchitis (HP:0100796)3.71809269
13Interstitial pulmonary disease (HP:0006530)3.69527188
14Entropion (HP:0000621)3.63131509
15Tetraparesis (HP:0002273)3.60129221
16Gingivitis (HP:0000230)3.57044593
17Elevated erythrocyte sedimentation rate (HP:0003565)3.54316738
18Reduced subcutaneous adipose tissue (HP:0003758)3.49470370
19Myositis (HP:0100614)3.42833570
20Retrobulbar optic neuritis (HP:0100654)3.41596463
21Optic neuritis (HP:0100653)3.41596463
22Increased mean platelet volume (HP:0011877)3.38311430
23Onycholysis (HP:0001806)3.37796546
24Vacuolated lymphocytes (HP:0001922)3.36617616
25Atrophic scars (HP:0001075)3.36306924
26Autoimmune thrombocytopenia (HP:0001973)3.28201945
27Thick nail (HP:0001805)3.07513765
28Dysostosis multiplex (HP:0000943)3.07358187
29Menorrhagia (HP:0000132)3.06837604
30Upper limb muscle weakness (HP:0003484)3.02672353
31Urticaria (HP:0001025)3.00799610
32Pulmonary infiltrates (HP:0002113)2.95289783
33Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.90071626
34Axonal loss (HP:0003447)2.89364961
35Abnormality of the distal phalanges of the toes (HP:0010182)2.86375302
36Abnormal platelet volume (HP:0011876)2.82788914
37Basal ganglia calcification (HP:0002135)2.73742629
38Abnormality of liposaccharide metabolism (HP:0010968)2.73001921
39Abnormality of glycosphingolipid metabolism (HP:0004343)2.73001921
40Abnormality of glycolipid metabolism (HP:0010969)2.73001921
41Vertebral compression fractures (HP:0002953)2.72983968
42Mucopolysacchariduria (HP:0008155)2.71881257
43Urinary glycosaminoglycan excretion (HP:0003541)2.71881257
44Fragile nails (HP:0001808)2.71530896
45Pustule (HP:0200039)2.71164289
46Trismus (HP:0000211)2.70793860
47Abnormality of binocular vision (HP:0011514)2.66946937
48Diplopia (HP:0000651)2.66946937
49Myocardial infarction (HP:0001658)2.66032042
50Aplasia involving bones of the extremities (HP:0009825)2.65776091
51Aplasia involving bones of the upper limbs (HP:0009823)2.65776091
52Aplasia of the phalanges of the hand (HP:0009802)2.65776091
53Abnormality of glycolysis (HP:0004366)2.65229040
54Obstructive lung disease (HP:0006536)2.63579869
55Chronic obstructive pulmonary disease (HP:0006510)2.63579869
56Recurrent skin infections (HP:0001581)2.61938808
57Poikiloderma (HP:0001029)2.59703731
58Fragile skin (HP:0001030)2.57949838
59Abnormal gallbladder physiology (HP:0012438)2.57517059
60Cholecystitis (HP:0001082)2.57517059
61Chronic otitis media (HP:0000389)2.56442285
62Nail dystrophy (HP:0008404)2.55880637
63Vasculitis (HP:0002633)2.55854378
64Male infertility (HP:0003251)2.55791308
65Periodontitis (HP:0000704)2.54279198
66Milia (HP:0001056)2.53428755
67Increased serum pyruvate (HP:0003542)2.52854991
68Abnormality of polysaccharide metabolism (HP:0011012)2.51655015
69Abnormality of glycosaminoglycan metabolism (HP:0004371)2.51655015
70Abnormality of mucopolysaccharide metabolism (HP:0011020)2.51655015
71Neurofibrillary tangles (HP:0002185)2.48462331
72Hypokinesia (HP:0002375)2.44596115
73Rough bone trabeculation (HP:0100670)2.43554592
74Systemic lupus erythematosus (HP:0002725)2.43054886
75Premature loss of primary teeth (HP:0006323)2.40717029
76Abnormality of the umbilical cord (HP:0010881)2.39808892
77Osteolytic defects of the phalanges of the hand (HP:0009771)2.39154618
78Osteolytic defects of the hand bones (HP:0009699)2.39154618
79Loss of speech (HP:0002371)2.38364643
80Natal tooth (HP:0000695)2.37817540
81Alopecia of scalp (HP:0002293)2.35032837
82Sparse eyelashes (HP:0000653)2.31764789
83Recurrent fungal infections (HP:0002841)2.27691073
84Protrusio acetabuli (HP:0003179)2.23192365
85Abnormalities of placenta or umbilical cord (HP:0001194)2.22244055
86Arterial tortuosity (HP:0005116)2.21712684
87Spinal cord lesions (HP:0100561)2.21707751
88Syringomyelia (HP:0003396)2.21707751
89Mitral stenosis (HP:0001718)2.18683161
90Pathologic fracture (HP:0002756)2.16984270
91Achilles tendon contracture (HP:0001771)2.16497868
92Selective tooth agenesis (HP:0001592)2.15220517
93Prostate neoplasm (HP:0100787)2.12272633
94Aplasia/Hypoplasia of the sacrum (HP:0008517)2.10931508
95Disinhibition (HP:0000734)2.10856001
96Leukocytosis (HP:0001974)2.10819764
97Abnormality of the Achilles tendon (HP:0005109)2.09597722
98Progressive visual loss (HP:0000529)2.09457691
99Abnormal auditory evoked potentials (HP:0006958)2.09032943
100Microglossia (HP:0000171)2.08400695
101Cellulitis (HP:0100658)2.06393712
102Increased IgM level (HP:0003496)2.06246718
103Abnormal umbilical cord blood vessels (HP:0011403)2.05040805
104Single umbilical artery (HP:0001195)2.05040805
105Abnormality of the fetal cardiovascular system (HP:0010948)2.05040805
106Xerostomia (HP:0000217)2.01337147
107Peritonitis (HP:0002586)2.01151928
108Distal lower limb amyotrophy (HP:0008944)1.99234849
109Albinism (HP:0001022)1.97349653
110Arterial thrombosis (HP:0004420)1.96895598
111Spondylolisthesis (HP:0003302)1.96297426
112Abnormality of placental membranes (HP:0011409)1.95418696
113Amniotic constriction ring (HP:0009775)1.95418696
114Multiple lipomas (HP:0001012)1.94829839
115Nuclear cataract (HP:0100018)1.93977739
116Glucose intolerance (HP:0000833)1.92933619
117Bone pain (HP:0002653)1.92745446
118Aortic dissection (HP:0002647)1.92690878
119Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.92378205
120Vertebral hypoplasia (HP:0008417)1.92378205
121Clumsiness (HP:0002312)1.92175396
122Deviation of the thumb (HP:0009603)1.91313151
123Purpura (HP:0000979)1.90937590
124Elbow flexion contracture (HP:0002987)1.90823737
125Cardiovascular calcification (HP:0011915)1.90070031
126Abnormal platelet function (HP:0011869)1.89721725
127Impaired platelet aggregation (HP:0003540)1.89721725
128Cervical subluxation (HP:0003308)1.89022226
129Vascular tortuosity (HP:0004948)1.88712434
130Increased IgE level (HP:0003212)1.88565294
131Squamous cell carcinoma (HP:0002860)1.88237664
132Abnormality of proline metabolism (HP:0010907)1.88134254
133Hydroxyprolinuria (HP:0003080)1.88134254
134Amyloidosis (HP:0011034)1.87911152
135Generalized amyotrophy (HP:0003700)1.87281601
136Abnormality of oral frenula (HP:0000190)1.86297311
137Tongue fasciculations (HP:0001308)1.85519075
138Neoplasm of head and neck (HP:0012288)1.85444089
139Esophageal neoplasm (HP:0100751)1.85444089
140Hypergammaglobulinemia (HP:0010702)1.85197844
141Palmoplantar hyperkeratosis (HP:0000972)1.84985909
142Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.84572635
143Hypoplasia of the capital femoral epiphysis (HP:0003090)1.84338620
144Adactyly (HP:0009776)1.83489062
145Orthostatic hypotension (HP:0001278)1.83351581
146Hepatosplenomegaly (HP:0001433)1.83129290
147Hypoplastic pelvis (HP:0008839)1.82911166
148Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.82172647
149Plantar hyperkeratosis (HP:0007556)1.81898983
150Fasciculations (HP:0002380)1.81787685
151Type I transferrin isoform profile (HP:0003642)1.81678131
152Anhidrosis (HP:0000970)1.80953643
153Abnormal trabecular bone morphology (HP:0100671)1.80292236
154Upper limb amyotrophy (HP:0009129)1.79910395
155Distal upper limb amyotrophy (HP:0007149)1.79910395
156Limb-girdle muscle atrophy (HP:0003797)1.79551686
157Pterygium (HP:0001059)1.77056985
158Petechiae (HP:0000967)1.76994023
159Recurrent corneal erosions (HP:0000495)1.76822238
160Adrenal hypoplasia (HP:0000835)1.76679926
161Absent frontal sinuses (HP:0002688)1.76165589
162Craniofacial hyperostosis (HP:0004493)1.75265368
163Progressive hearing impairment (HP:0001730)1.75183765
164Vascular calcification (HP:0004934)1.75119055
165Abnormality of the frontal sinuses (HP:0002687)1.74493657
166Progressive neurologic deterioration (HP:0002344)1.74456937
167Broad face (HP:0000283)1.74368117
168Osteomyelitis (HP:0002754)1.73821568
169Nasal polyposis (HP:0100582)1.73678281
170Abnormality of the anterior horn cell (HP:0006802)1.72894438
171Degeneration of anterior horn cells (HP:0002398)1.72894438
172Shoulder girdle muscle weakness (HP:0003547)1.72754768
173Sepsis (HP:0100806)1.71790128
174Hematochezia (HP:0002573)1.71607138
175Palmar hyperkeratosis (HP:0010765)1.71522277
176Episodic fever (HP:0001954)1.71132316
177Ankyloglossia (HP:0010296)1.70805534
178Reduced antithrombin III activity (HP:0001976)1.70689426
179Prolonged neonatal jaundice (HP:0006579)1.69987461
180Breast hypoplasia (HP:0003187)1.69617448
181Distal lower limb muscle weakness (HP:0009053)1.69387124
182Abnormal autonomic nervous system physiology (HP:0012332)1.69160181

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K144.76084672
2EPHA24.73924467
3RIPK44.35280027
4BUB13.27755590
5TBK13.22626635
6IRAK33.20530437
7TYK22.55627572
8PIM22.52523934
9BLK2.51119660
10EIF2AK12.41991037
11ERN12.36550567
12PBK2.30488229
13TAOK22.19783003
14IKBKE2.08379339
15PAK42.05152472
16TRIB32.01870606
17TESK21.98176731
18IKBKB1.97468452
19MAP3K131.92027600
20LIMK11.90750195
21IRAK41.86203743
22NEK11.85390502
23EIF2AK31.83643327
24CSK1.82273078
25NME21.82121025
26JAK31.76869914
27FGR1.71532768
28VRK21.68683520
29STK101.62003613
30MST1R1.57702632
31MST41.56619374
32EPHB11.55178302
33CHUK1.54550838
34CDK81.52932647
35BMX1.48907436
36LRRK21.46040948
37STK241.39883827
38ARAF1.39301307
39KIT1.34592259
40MAP4K11.30339583
41TXK1.30249318
42EPHB21.29535351
43MAP3K31.29198489
44MAP3K121.20877600
45SRPK11.17918363
46MATK1.17159259
47TTK1.17096536
48JAK11.16897520
49SCYL21.16845555
50ZAP701.13301879
51MOS1.12509916
52PTK61.09464590
53TSSK61.06093738
54EPHA31.03806657
55MYLK1.03105665
56TRPM71.00614517
57LYN1.00494060
58LATS21.00147455
59ILK0.99324418
60MARK30.97315624
61MAP3K50.95978638
62HCK0.95628654
63MAP3K10.93885277
64TRIM280.93206381
65PIM10.88204062
66BRSK10.88144526
67ABL20.85271936
68WEE10.84495098
69TGFBR20.83852960
70STK30.82573942
71RPS6KA40.82382248
72TAOK10.82333116
73BRAF0.80941478
74JAK20.80117043
75SIK10.79943240
76FLT30.79293751
77ERBB30.78891258
78ICK0.77199515
79FGFR30.75604965
80LCK0.74607043
81TAOK30.73710547
82FES0.73243190
83RIPK10.73109658
84ABL10.72073505
85ERBB40.71143205
86PAK10.70791385
87CLK10.70418001
88AURKA0.70001436
89PTK2B0.69663107
90MET0.69480012
91PLK10.69246872
92YES10.68291638
93ADRBK10.67073443
94PDGFRA0.66952956
95DAPK10.66601586
96SIK30.66402034
97PRKCQ0.66310799
98SYK0.65495249
99BMPR20.65207864
100NEK20.64512045
101PAK20.64487860
102PLK30.63416073
103PRKG20.63192747
104BTK0.63014104
105CCNB10.62919524
106DDR20.61453637
107STK160.60901698
108EGFR0.59868960
109RAF10.59746263
110STK40.59095755
111LMTK20.58176576
112KSR20.57613239
113BRSK20.57406472
114LATS10.57177661
115PRKCD0.56714173
116MUSK0.56190138
117PIK3CG0.55491408
118SMG10.55009471
119AURKB0.54282299
120MAP4K20.53390340
121MAP3K110.52859519
122MAP2K30.52401807
123PDGFRB0.51419779
124NTRK10.50900765
125ADRBK20.50610903
126CHEK20.49979577
127PRKCI0.48217413
128EIF2AK20.47543602
129NME10.47245505
130ROCK20.47171007
131CAMK2G0.47021853
132TTN0.46974005
133CDK70.46498566
134MAP3K20.46239201
135MAPKAPK20.46177882
136MAP3K80.43436900
137HIPK20.41509077
138MELK0.40892001
139FYN0.39844141
140TESK10.39346980
141IGF1R0.38484715
142PTK20.37433475
143NEK90.37338756
144GRK70.37311501
145FGFR10.36822337
146MAP3K90.36549517
147TEC0.35922814
148MAPK40.35350566
149DAPK30.34776091
150PRKCE0.34287192
151INSR0.33599488
152SRC0.33215155
153CDK90.31887707
154PAK60.31850055
155CDK140.30350099
156PLK20.30168481
157KSR10.29396628
158CAMK2D0.28167662
159MAP3K60.26280520
160IRAK20.26235350
161VRK10.25304313
162CSNK1A1L0.23020343
163STK380.22969121

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030503.47451264
2Leishmaniasis_Homo sapiens_hsa051403.09906248
3Legionellosis_Homo sapiens_hsa051342.93816668
4Malaria_Homo sapiens_hsa051442.87773905
5Toll-like receptor signaling pathway_Homo sapiens_hsa046202.78350929
6Graft-versus-host disease_Homo sapiens_hsa053322.61959837
7DNA replication_Homo sapiens_hsa030302.44356363
8Staphylococcus aureus infection_Homo sapiens_hsa051502.44163094
9Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005202.28513147
10Nucleotide excision repair_Homo sapiens_hsa034202.26113964
11Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.23894662
12Osteoclast differentiation_Homo sapiens_hsa043802.21948312
13Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.21790330
14Mismatch repair_Homo sapiens_hsa034302.21530640
15NF-kappa B signaling pathway_Homo sapiens_hsa040642.18956520
16Pyrimidine metabolism_Homo sapiens_hsa002402.17408531
17NOD-like receptor signaling pathway_Homo sapiens_hsa046212.11157766
18Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.10611993
19Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.07420805
20Asthma_Homo sapiens_hsa053102.06396471
21TNF signaling pathway_Homo sapiens_hsa046682.00157825
22Pentose phosphate pathway_Homo sapiens_hsa000302.00068468
23Lysosome_Homo sapiens_hsa041421.97558055
24Tuberculosis_Homo sapiens_hsa051521.94181687
25Pertussis_Homo sapiens_hsa051331.91536770
26Salmonella infection_Homo sapiens_hsa051321.90675495
27Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.85952624
28Galactose metabolism_Homo sapiens_hsa000521.85353800
29Rheumatoid arthritis_Homo sapiens_hsa053231.83167966
30Base excision repair_Homo sapiens_hsa034101.78425233
31Fatty acid elongation_Homo sapiens_hsa000621.74224815
32Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.71255319
33Type I diabetes mellitus_Homo sapiens_hsa049401.69619575
34Glutathione metabolism_Homo sapiens_hsa004801.68563003
35African trypanosomiasis_Homo sapiens_hsa051431.67110223
36Glycosaminoglycan degradation_Homo sapiens_hsa005311.67020234
37Allograft rejection_Homo sapiens_hsa053301.65417360
38Phagosome_Homo sapiens_hsa041451.64728296
39Folate biosynthesis_Homo sapiens_hsa007901.64112621
40Biosynthesis of amino acids_Homo sapiens_hsa012301.62667483
41Measles_Homo sapiens_hsa051621.55398468
42Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.51830930
43Toxoplasmosis_Homo sapiens_hsa051451.50887973
44Shigellosis_Homo sapiens_hsa051311.50095949
45Sulfur metabolism_Homo sapiens_hsa009201.48899461
46Cell cycle_Homo sapiens_hsa041101.48817647
47Sulfur relay system_Homo sapiens_hsa041221.47729823
48Mineral absorption_Homo sapiens_hsa049781.46857663
49Fructose and mannose metabolism_Homo sapiens_hsa000511.46659244
50Influenza A_Homo sapiens_hsa051641.45010198
51Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.42324949
52Carbon metabolism_Homo sapiens_hsa012001.42246819
53p53 signaling pathway_Homo sapiens_hsa041151.40843748
54N-Glycan biosynthesis_Homo sapiens_hsa005101.36403554
55RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.32191302
56Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.31972166
57Hematopoietic cell lineage_Homo sapiens_hsa046401.30892317
58Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.30831486
59Fatty acid biosynthesis_Homo sapiens_hsa000611.24851340
60B cell receptor signaling pathway_Homo sapiens_hsa046621.23594691
61Vibrio cholerae infection_Homo sapiens_hsa051101.22376576
62Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.22186254
63Apoptosis_Homo sapiens_hsa042101.21396692
64Other glycan degradation_Homo sapiens_hsa005111.20348929
65RNA polymerase_Homo sapiens_hsa030201.19741485
66Amoebiasis_Homo sapiens_hsa051461.18960470
67Homologous recombination_Homo sapiens_hsa034401.17492536
68AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.16521535
69Sphingolipid metabolism_Homo sapiens_hsa006001.15124888
70Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.13843428
71Chemokine signaling pathway_Homo sapiens_hsa040621.13373749
72Jak-STAT signaling pathway_Homo sapiens_hsa046301.12840607
73Leukocyte transendothelial migration_Homo sapiens_hsa046701.12680957
74RNA transport_Homo sapiens_hsa030131.11440875
752-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.09676547
76Viral myocarditis_Homo sapiens_hsa054161.06327781
77Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.04822644
78Hepatitis C_Homo sapiens_hsa051601.02024514
79Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.99833900
80Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.97925349
81Non-homologous end-joining_Homo sapiens_hsa034500.97258921
82Adipocytokine signaling pathway_Homo sapiens_hsa049200.96836444
83Pyruvate metabolism_Homo sapiens_hsa006200.96520699
84Herpes simplex infection_Homo sapiens_hsa051680.96469775
85Cysteine and methionine metabolism_Homo sapiens_hsa002700.94072204
86One carbon pool by folate_Homo sapiens_hsa006700.92903305
87Central carbon metabolism in cancer_Homo sapiens_hsa052300.91331208
88Purine metabolism_Homo sapiens_hsa002300.87426180
89Hepatitis B_Homo sapiens_hsa051610.87390993
90Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.86846254
91Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.81563985
92Spliceosome_Homo sapiens_hsa030400.80671013
93Proteoglycans in cancer_Homo sapiens_hsa052050.80297917
94Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.78989517
95Sphingolipid signaling pathway_Homo sapiens_hsa040710.78272232
96Antigen processing and presentation_Homo sapiens_hsa046120.78236330
97Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.78141343
98Ribosome_Homo sapiens_hsa030100.76682188
99Intestinal immune network for IgA production_Homo sapiens_hsa046720.74888861
100Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.74333381
101Huntingtons disease_Homo sapiens_hsa050160.74160799
102Steroid biosynthesis_Homo sapiens_hsa001000.73603123
103Vitamin B6 metabolism_Homo sapiens_hsa007500.73508696
104Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.70551380
105Autoimmune thyroid disease_Homo sapiens_hsa053200.69624509
106Chronic myeloid leukemia_Homo sapiens_hsa052200.69470994
107Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.68008279
108Thyroid cancer_Homo sapiens_hsa052160.67166198
109Neurotrophin signaling pathway_Homo sapiens_hsa047220.66258835
110Renin-angiotensin system_Homo sapiens_hsa046140.66227908
111Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.66226246
112Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.66067280
113Caffeine metabolism_Homo sapiens_hsa002320.64606799
114Prion diseases_Homo sapiens_hsa050200.64094171
115Hippo signaling pathway_Homo sapiens_hsa043900.63426108
116Basal transcription factors_Homo sapiens_hsa030220.62689100
117Fanconi anemia pathway_Homo sapiens_hsa034600.62560135
118MicroRNAs in cancer_Homo sapiens_hsa052060.62490660
119SNARE interactions in vesicular transport_Homo sapiens_hsa041300.60476976
120Acute myeloid leukemia_Homo sapiens_hsa052210.59841294
121Pancreatic cancer_Homo sapiens_hsa052120.59679454
122Carbohydrate digestion and absorption_Homo sapiens_hsa049730.57624865
123Platelet activation_Homo sapiens_hsa046110.55967887
124Small cell lung cancer_Homo sapiens_hsa052220.54748038
125Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.54494410
126Viral carcinogenesis_Homo sapiens_hsa052030.54305974
127T cell receptor signaling pathway_Homo sapiens_hsa046600.53790151
128Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.53606128
129ECM-receptor interaction_Homo sapiens_hsa045120.51014695
130Protein export_Homo sapiens_hsa030600.50531880
131Dorso-ventral axis formation_Homo sapiens_hsa043200.50526698
132Regulation of actin cytoskeleton_Homo sapiens_hsa048100.49423814
133Prolactin signaling pathway_Homo sapiens_hsa049170.48755299
134Drug metabolism - other enzymes_Homo sapiens_hsa009830.47198347
135Metabolic pathways_Homo sapiens_hsa011000.45295902
136Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.44179531
137Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.44156328
138Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.43461238
139Adherens junction_Homo sapiens_hsa045200.43403701
140TGF-beta signaling pathway_Homo sapiens_hsa043500.43265034
141Type II diabetes mellitus_Homo sapiens_hsa049300.41160352
142Epstein-Barr virus infection_Homo sapiens_hsa051690.39809685
143Focal adhesion_Homo sapiens_hsa045100.38562981
144Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.38499240
145Oxidative phosphorylation_Homo sapiens_hsa001900.36121154
146Phospholipase D signaling pathway_Homo sapiens_hsa040720.35803532
147VEGF signaling pathway_Homo sapiens_hsa043700.35170647
148Notch signaling pathway_Homo sapiens_hsa043300.35161545
149Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.34884381
150HIF-1 signaling pathway_Homo sapiens_hsa040660.34780823
151Alzheimers disease_Homo sapiens_hsa050100.33017294
152Complement and coagulation cascades_Homo sapiens_hsa046100.32052757
153Prostate cancer_Homo sapiens_hsa052150.31991790
154Parkinsons disease_Homo sapiens_hsa050120.31888566
155Renal cell carcinoma_Homo sapiens_hsa052110.31322180
156Endocytosis_Homo sapiens_hsa041440.31051248
157Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.31037744
158Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.28619163
159Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.27841301
160Bladder cancer_Homo sapiens_hsa052190.27791467
161Insulin resistance_Homo sapiens_hsa049310.26754838
162Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.25560882

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