ADORA2A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor (GPCR) superfamily, which is subdivided into classes and subtypes. The receptors are seven-pass transmembrane proteins that respond to extracellular cues and activate intracellular signal transduction pathways. This protein, an adenosine receptor of A2A subtype, uses adenosine as the preferred endogenous agonist and preferentially interacts with the G(s) and G(olf) family of G proteins to increase intracellular cAMP levels. It plays an important role in many biological functions, such as cardiac rhythm and circulation, cerebral and renal blood flow, immune function, pain regulation, and sleep. It has been implicated in pathophysiological conditions such as inflammatory diseases and neurodegenerative disorders. Alternative splicing results in multiple transcript variants. A read-through transcript composed of the upstream SPECC1L (sperm antigen with calponin homology and coiled-coil domains 1-like) and ADORA2A (adenosine A2a receptor) gene sequence has been identified, but it is thought to be non-coding. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of synapse structural plasticity (GO:0051823)6.43210545
2adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)5.55061084
3striatum development (GO:0021756)5.27348318
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.13883397
5positive regulation of synaptic transmission, dopaminergic (GO:0032226)5.07359316
6locomotory exploration behavior (GO:0035641)5.04397352
7negative regulation of interleukin-12 production (GO:0032695)5.01895783
8negative regulation of cytosolic calcium ion concentration (GO:0051481)4.96931041
9regulation of vitamin D biosynthetic process (GO:0060556)4.96483907
10* synaptic transmission, dopaminergic (GO:0001963)4.94156860
11dopamine receptor signaling pathway (GO:0007212)4.92316528
12synaptic vesicle maturation (GO:0016188)4.91774663
13response to peptidoglycan (GO:0032494)4.71479553
14regulation of T-helper 1 cell differentiation (GO:0045625)4.66369909
15auditory behavior (GO:0031223)4.66202094
16regulation of long-term neuronal synaptic plasticity (GO:0048169)4.65744783
17* prepulse inhibition (GO:0060134)4.61974897
18cAMP catabolic process (GO:0006198)4.60020608
19positive regulation of gamma-delta T cell activation (GO:0046645)4.56250595
20membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.51760862
21* response to amphetamine (GO:0001975)4.37860162
22lipopolysaccharide-mediated signaling pathway (GO:0031663)4.36302182
23* adenosine receptor signaling pathway (GO:0001973)4.31676142
24regulation of chronic inflammatory response (GO:0002676)4.29780345
25regulation of short-term neuronal synaptic plasticity (GO:0048172)4.28561631
26G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)4.24136232
27positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.23021168
28substrate-independent telencephalic tangential migration (GO:0021826)4.21472932
29substrate-independent telencephalic tangential interneuron migration (GO:0021843)4.21472932
30regulation of neuronal synaptic plasticity (GO:0048168)4.13469505
31NIK/NF-kappaB signaling (GO:0038061)4.11519735
32regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.10906249
33negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.09489702
34regulation of glutamate receptor signaling pathway (GO:1900449)4.08558548
35response to auditory stimulus (GO:0010996)4.08062662
36macrophage activation involved in immune response (GO:0002281)4.03904646
37regulation of dendritic spine morphogenesis (GO:0061001)4.03454715
38neuromuscular process controlling balance (GO:0050885)4.00548544
39regulation of female receptivity (GO:0045924)4.00288276
40regulation of dopamine uptake involved in synaptic transmission (GO:0051584)3.95163376
41regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)3.95163376
42cyclic nucleotide catabolic process (GO:0009214)3.94033802
43type I interferon signaling pathway (GO:0060337)3.92280234
44cellular response to type I interferon (GO:0071357)3.92280234
45phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.90202432
46neutrophil activation involved in immune response (GO:0002283)3.89649693
47negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.89204985
48regulation of vitamin metabolic process (GO:0030656)3.88036712
49behavioral response to cocaine (GO:0048148)3.87606741
50response to type I interferon (GO:0034340)3.87158891
51neurotransmitter-gated ion channel clustering (GO:0072578)3.87142434
52germinal center formation (GO:0002467)3.85999746
53positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.85300878
54positive regulation of chemokine biosynthetic process (GO:0045080)3.84904373
55vocalization behavior (GO:0071625)3.84293124
56regulation of cytokine secretion involved in immune response (GO:0002739)3.83203289
57immunoglobulin mediated immune response (GO:0016064)3.79227169
58defense response to protozoan (GO:0042832)3.77294881
59T-helper 1 type immune response (GO:0042088)3.75019742
60regulation of podosome assembly (GO:0071801)3.74790224
61positive regulation of heat generation (GO:0031652)3.72640061
62response to protozoan (GO:0001562)3.71478833
63positive regulation by organism of defense response of other organism involved in symbiotic interact3.71386904
64modulation by symbiont of host immune response (GO:0052553)3.71386904
65positive regulation by symbiont of host defense response (GO:0052509)3.71386904
66modulation by symbiont of host defense response (GO:0052031)3.71386904
67modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.71386904
68modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.71386904
69regulation of fever generation (GO:0031620)3.68309244
70myeloid dendritic cell differentiation (GO:0043011)3.65295284
71regulation of Rap GTPase activity (GO:0032317)3.62377570
72positive regulation of Rap GTPase activity (GO:0032854)3.62134939
73regulation of interferon-alpha production (GO:0032647)3.61759456
74negative regulation of cytokine production involved in immune response (GO:0002719)3.60917149
75regulation of chemokine biosynthetic process (GO:0045073)3.59016944
76visual learning (GO:0008542)3.54693224
77regulation of dendritic cell antigen processing and presentation (GO:0002604)3.54358006
78negative regulation of amino acid transport (GO:0051956)3.51494208
79peristalsis (GO:0030432)3.49956842
80T cell migration (GO:0072678)3.49679322
81positive regulation of NF-kappaB import into nucleus (GO:0042346)3.46049125
82granulocyte activation (GO:0036230)3.46031352
83activation of protein kinase A activity (GO:0034199)3.45749861
84regulation of neurotransmitter uptake (GO:0051580)3.45383280
85positive regulation of type 2 immune response (GO:0002830)3.45338791
86interferon-gamma-mediated signaling pathway (GO:0060333)3.45172967
87positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.43510284
88long-term memory (GO:0007616)3.42518644
89regulation of interferon-beta biosynthetic process (GO:0045357)3.40373545
90ionotropic glutamate receptor signaling pathway (GO:0035235)3.40103821
91positive regulation of membrane potential (GO:0045838)3.38826271
92female mating behavior (GO:0060180)3.36421281
93leukocyte aggregation (GO:0070486)3.34943473
94regulation of interleukin-12 production (GO:0032655)3.34305584
95positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.34203887
96neuronal ion channel clustering (GO:0045161)3.33692153
97synaptic vesicle docking involved in exocytosis (GO:0016081)3.33305924
98* positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.33139650
99regulation of T cell tolerance induction (GO:0002664)3.33036557
100regulation of voltage-gated calcium channel activity (GO:1901385)3.32342130
101dendritic spine morphogenesis (GO:0060997)3.31695687
102synaptic vesicle exocytosis (GO:0016079)3.29395326
103mechanosensory behavior (GO:0007638)3.28550293
104* cAMP metabolic process (GO:0046058)3.26862153
105positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)3.26549803
106negative regulation of dendrite development (GO:2000171)3.26442729
107neurotransmitter secretion (GO:0007269)3.26416770
108visual behavior (GO:0007632)3.25638190
109response to muramyl dipeptide (GO:0032495)3.24554687
110regulation of synaptic vesicle exocytosis (GO:2000300)3.24507569
111myeloid dendritic cell activation (GO:0001773)3.23396694
112regulation of gamma-delta T cell activation (GO:0046643)3.23342796
113exploration behavior (GO:0035640)3.21698696
114positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.21325673
115regulation of mononuclear cell migration (GO:0071675)3.20866116
116antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.16505383
117antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.16160128
118positive regulation of interferon-alpha production (GO:0032727)3.15887587
119regulation of T-helper 2 cell differentiation (GO:0045628)3.14242205
120negative thymic T cell selection (GO:0045060)3.12145853
121response to histamine (GO:0034776)3.10814029
122positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.09709704
123regulation of immunoglobulin secretion (GO:0051023)3.07906953
124regulation of protein kinase A signaling (GO:0010738)3.07591183
125regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)3.07528136
126neutrophil activation (GO:0042119)3.07452585
127glycine transport (GO:0015816)3.07384265
128detection of other organism (GO:0098543)3.07355611
129transmission of nerve impulse (GO:0019226)3.07265923
130regulation of interleukin-2 biosynthetic process (GO:0045076)3.07190208
131regulation of antigen processing and presentation (GO:0002577)3.07145362
132regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.06736259
133behavioral fear response (GO:0001662)3.06031377
134behavioral defense response (GO:0002209)3.06031377
135regulation of T-helper cell differentiation (GO:0045622)3.05300891
136positive regulation of T-helper cell differentiation (GO:0045624)3.04896683
137regulation of synaptic transmission, dopaminergic (GO:0032225)3.04155919
138* regulation of excitatory postsynaptic membrane potential (GO:0060079)3.03845204
139drinking behavior (GO:0042756)3.03545717
140neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)3.02321019
141* regulation of synaptic plasticity (GO:0048167)3.00984898
142layer formation in cerebral cortex (GO:0021819)3.00865151
143monocyte chemotaxis (GO:0002548)2.99575452
144cellular response to lipopolysaccharide (GO:0071222)2.99086909
145* regulation of synaptic transmission, glutamatergic (GO:0051966)2.98938913
146regulation of dendritic spine development (GO:0060998)2.97980308
147gamma-aminobutyric acid transport (GO:0015812)2.97852411
148regulation of ARF protein signal transduction (GO:0032012)2.97402739
149cGMP metabolic process (GO:0046068)2.96180632
150antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.95147586
151negative T cell selection (GO:0043383)2.94954851
152protein localization to synapse (GO:0035418)2.94948071
153regulation of tolerance induction (GO:0002643)2.94716683
154positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.94709069
155cellular response to molecule of bacterial origin (GO:0071219)2.93254573
156detection of bacterium (GO:0016045)2.93240165
157antigen processing and presentation of endogenous antigen (GO:0019883)2.92747950
158myeloid cell activation involved in immune response (GO:0002275)2.92388926
159positive regulation of interleukin-12 production (GO:0032735)2.92364606
160regulation of synaptic vesicle transport (GO:1902803)2.91868343
161B cell mediated immunity (GO:0019724)2.91845046
162regulation of type 2 immune response (GO:0002828)2.91366664
163dendritic cell differentiation (GO:0097028)2.90406654
164* neuron-neuron synaptic transmission (GO:0007270)2.89204908
165negative regulation of production of molecular mediator of immune response (GO:0002701)2.88545975
166negative regulation of amine transport (GO:0051953)2.88486343
167regulation of interleukin-8 biosynthetic process (GO:0045414)2.88436697
168regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.88015333
169positive regulation of antigen processing and presentation (GO:0002579)2.87737226
170negative regulation of myeloid cell apoptotic process (GO:0033033)2.86514339
171neuronal action potential propagation (GO:0019227)2.86449446
172* response to amine (GO:0014075)2.86239799
173negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.85904191
174positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.85865285
175positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.83888050
176positive regulation of interleukin-10 production (GO:0032733)2.83635861
177regulation of NF-kappaB import into nucleus (GO:0042345)2.83462510
178cellular response to interferon-gamma (GO:0071346)2.82250754
179negative regulation of T cell mediated immunity (GO:0002710)2.81972731
180long-term synaptic potentiation (GO:0060291)2.81172762
181positive regulation of interleukin-2 production (GO:0032743)2.81119604
182positive regulation of tolerance induction (GO:0002645)2.80503675
183regulation of heat generation (GO:0031650)2.80446392
184positive regulation of acute inflammatory response (GO:0002675)2.79806899
185regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.79146196
186regulation of membrane protein ectodomain proteolysis (GO:0051043)2.79084681
187negative regulation of dendrite morphogenesis (GO:0050774)2.76375454
188positive regulation of vesicle fusion (GO:0031340)2.75458009
189G-protein coupled receptor internalization (GO:0002031)2.75093671
190* positive regulation of neurotransmitter transport (GO:0051590)2.74784797
191response to morphine (GO:0043278)2.74598084
192regulation of vesicle fusion (GO:0031338)2.74457466
193learning (GO:0007612)2.72426524
194serotonin metabolic process (GO:0042428)2.70774926
195regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.70698623
196* regulation of postsynaptic membrane potential (GO:0060078)2.69085103
197neuromuscular process (GO:0050905)2.69003348
198associative learning (GO:0008306)2.67587918
199negative regulation of cell killing (GO:0031342)2.64942376

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RARB_27405468_Chip-Seq_BRAIN_Mouse4.21192701
2MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.40954083
3IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.38599008
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.11362110
5* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.04262600
6NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.97777794
7EZH2_22144423_ChIP-Seq_EOC_Human2.75418490
8DROSHA_22980978_ChIP-Seq_HELA_Human2.67151929
9IKZF1_21737484_ChIP-ChIP_HCT116_Human2.63528275
10EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.56456267
11SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.50513476
12RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.36848647
13* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.36300093
14* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.33210601
15VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.25807403
16JARID2_20064375_ChIP-Seq_MESCs_Mouse2.25443684
17Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.22227717
18* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.16980842
19* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.12362956
20JARID2_20075857_ChIP-Seq_MESCs_Mouse2.09595232
21RNF2_18974828_ChIP-Seq_MESCs_Mouse2.07376199
22EZH2_18974828_ChIP-Seq_MESCs_Mouse2.07376199
23SPI1_23547873_ChIP-Seq_NB4_Human2.04446877
24BRD4_27068464_Chip-Seq_AML-cells_Mouse2.04296020
25* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.00940201
26REST_21632747_ChIP-Seq_MESCs_Mouse2.00696988
27* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.00266445
28* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.97552225
29KDM2B_26808549_Chip-Seq_SUP-B15_Human1.93742755
30* MYB_26560356_Chip-Seq_TH2_Human1.87473493
31DNAJC2_21179169_ChIP-ChIP_NT2_Human1.85657106
32BP1_19119308_ChIP-ChIP_Hs578T_Human1.83150126
33GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.80781635
34KDM2B_26808549_Chip-Seq_K562_Human1.80596249
35STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.80114626
36REST_18959480_ChIP-ChIP_MESCs_Mouse1.80044789
37SCL_19346495_ChIP-Seq_HPC-7_Human1.79093604
38* RUNX1_22412390_ChIP-Seq_EML_Mouse1.78289838
39* EZH2_27294783_Chip-Seq_ESCs_Mouse1.77619137
40MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.76519523
41IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.73406844
42RNF2_27304074_Chip-Seq_ESCs_Mouse1.71631891
43IRF8_22096565_ChIP-ChIP_GC-B_Human1.71364320
44STAT6_21828071_ChIP-Seq_BEAS2B_Human1.69495482
45AR_21572438_ChIP-Seq_LNCaP_Human1.68925796
46* UTX_26944678_Chip-Seq_JUKART_Human1.68742078
47IRF8_21731497_ChIP-ChIP_J774_Mouse1.67767605
48* KDM2B_26808549_Chip-Seq_DND41_Human1.67477912
49PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.65739408
50LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.65507282
51ERG_21242973_ChIP-ChIP_JURKAT_Human1.65370186
52THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.61719315
53EZH2_27304074_Chip-Seq_ESCs_Mouse1.61029388
54LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.58063067
55* MYB_26560356_Chip-Seq_TH1_Human1.56544735
56NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.55534824
57CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.55372468
58EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.55366500
59SMAD_19615063_ChIP-ChIP_OVARY_Human1.55282722
60MAF_26560356_Chip-Seq_TH2_Human1.53996692
61SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.51970152
62SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.49156496
63GATA1_22025678_ChIP-Seq_K562_Human1.48608253
64TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.46229433
65TCF7_22412390_ChIP-Seq_EML_Mouse1.44900021
66TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.44064348
67NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.44028103
68RUNX_20019798_ChIP-Seq_JUKART_Human1.43137092
69FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.42518594
70WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.42096200
71SPI1_23127762_ChIP-Seq_K562_Human1.41130649
72KDM2B_26808549_Chip-Seq_JURKAT_Human1.39041448
73GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.37374496
74SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.35695992
75ZFP281_18757296_ChIP-ChIP_E14_Mouse1.34180807
76CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.33990944
77PU_27001747_Chip-Seq_BMDM_Mouse1.33567881
78* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.33362650
79SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.32199015
80PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.31769001
81KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.30784670
82STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.28861570
83ZFP281_27345836_Chip-Seq_ESCs_Mouse1.28653807
84* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.27894503
85FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.27434242
86GATA3_27048872_Chip-Seq_THYMUS_Human1.26540365
87GBX2_23144817_ChIP-Seq_PC3_Human1.25758308
88LXR_22292898_ChIP-Seq_THP-1_Human1.25593242
89* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.24650505
90CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.23810833
91CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.21228679
92GATA2_22383799_ChIP-Seq_G1ME_Mouse1.19920615
93WT1_25993318_ChIP-Seq_PODOCYTE_Human1.19234062
94CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.18952481
95* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.18645478
96P53_22127205_ChIP-Seq_FIBROBLAST_Human1.16149550
97* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.15493572
98CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.11901971
99DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.11460064
100PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.11292560
101MAF_26560356_Chip-Seq_TH1_Human1.10611226
102RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.10284225
103GATA2_21666600_ChIP-Seq_HMVEC_Human1.09736415
104GATA3_26560356_Chip-Seq_TH2_Human1.08306540
105GATA1_22383799_ChIP-Seq_G1ME_Mouse1.06230112
106* MYC_22102868_ChIP-Seq_BL_Human1.05233595
107GATA1_19941826_ChIP-Seq_K562_Human1.03953950
108IRF8_27001747_Chip-Seq_BMDM_Mouse1.03176616
109* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.01421163
110MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.00356927
111BCL6_27268052_Chip-Seq_Bcells_Human1.00001823
112KLF4_19829295_ChIP-Seq_ESCs_Human0.99655697
113EGR1_19374776_ChIP-ChIP_THP-1_Human0.99600406
114CTCF_27219007_Chip-Seq_Bcells_Human0.99396121
115RXR_22108803_ChIP-Seq_LS180_Human0.99053190
116STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.97822370
117RING1B_27294783_Chip-Seq_ESCs_Mouse0.96280789
118SMAD3_21741376_ChIP-Seq_HESCs_Human0.96035491
119BCOR_27268052_Chip-Seq_Bcells_Human0.95756718
120FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.95646178
121GATA1_19941827_ChIP-Seq_MEL_Mouse0.95545696
122SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.95057516
123VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.94409079
124GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93310639
125SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.93157044
126SMC4_20622854_ChIP-Seq_HELA_Human0.91889979
127EED_16625203_ChIP-ChIP_MESCs_Mouse0.90770089
128ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.90316581
129VDR_24787735_ChIP-Seq_THP-1_Human0.90315711
130TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.90092504
131ESR2_21235772_ChIP-Seq_MCF-7_Human0.88667069
132* ELK3_25401928_ChIP-Seq_HUVEC_Human0.87570875
133NCOR1_26117541_ChIP-Seq_K562_Human0.87004125
134RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.86918926
135AR_19668381_ChIP-Seq_PC3_Human0.86801154
136ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.86076047
137VDR_24763502_ChIP-Seq_THP-1_Human0.86011966
138NOTCH1_21737748_ChIP-Seq_TLL_Human0.85921746
139ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.85802391
140NR3C1_23031785_ChIP-Seq_PC12_Mouse0.85785571
141GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85351758
142RING1B_27294783_Chip-Seq_NPCs_Mouse0.83281714
143TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.83135295
144STAT1_20625510_ChIP-Seq_HELA_Human0.82851175
145ELF1_20517297_ChIP-Seq_JURKAT_Human0.82548114
146CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.82208084
147OCT4_19829295_ChIP-Seq_ESCs_Human0.81124018
148TFEB_21752829_ChIP-Seq_HELA_Human0.80681762
149* CREB1_26743006_Chip-Seq_LNCaP_Human0.80354743
150EGR1_19032775_ChIP-ChIP_M12_Human0.80009005
151* DPY_21335234_ChIP-Seq_ESCs_Mouse0.79273527
152SOX2_21211035_ChIP-Seq_LN229_Gbm0.78959901
153CTCF_27219007_Chip-Seq_ERYTHROID_Human0.78387562
154TET1_21490601_ChIP-Seq_MESCs_Mouse0.78153137
155VDR_21846776_ChIP-Seq_THP-1_Human0.77657564
156SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.77634687
157MYB_21317192_ChIP-Seq_ERMYB_Mouse0.77372702
158* STAT4_19710469_ChIP-ChIP_TH1__Mouse0.77034884
159* TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.76724065

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.62256215
2MP0003724_increased_susceptibility_to3.66402450
3MP0003635_abnormal_synaptic_transmissio3.44221849
4* MP0009745_abnormal_behavioral_response3.17255801
5* MP0002063_abnormal_learning/memory/cond2.87912959
6MP0003880_abnormal_central_pattern2.86703225
7MP0001529_abnormal_vocalization2.62561295
8MP0002064_seizures2.45984565
9MP0002909_abnormal_adrenal_gland2.40303186
10MP0009764_decreased_sensitivity_to2.33731700
11MP0005058_abnormal_lysosome_morphology2.33731626
12MP0004270_analgesia2.33720539
13MP0009046_muscle_twitch2.21919182
14MP0004510_myositis2.17132262
15MP0001486_abnormal_startle_reflex2.15695680
16* MP0002572_abnormal_emotion/affect_behav2.14664833
17MP0005423_abnormal_somatic_nervous2.08582821
18MP0001501_abnormal_sleep_pattern2.05773770
19MP0001533_abnormal_skeleton_physiology2.02423706
20MP0002822_catalepsy10.0604412
21MP0002139_abnormal_hepatobiliary_system1.98565128
22MP0003303_peritoneal_inflammation1.97997431
23MP0002272_abnormal_nervous_system1.90248309
24MP0001845_abnormal_inflammatory_respons1.88589758
25MP0009840_abnormal_foam_cell1.87543140
26MP0002405_respiratory_system_inflammati1.86994517
27MP0005167_abnormal_blood-brain_barrier1.85895853
28MP0009278_abnormal_bone_marrow1.76654484
29MP0009333_abnormal_splenocyte_physiolog1.76227147
30MP0001968_abnormal_touch/_nociception1.75728489
31MP0005451_abnormal_body_composition1.75534711
32MP0008004_abnormal_stomach_pH1.74314454
33MP0004924_abnormal_behavior1.72536030
34MP0005386_behavior/neurological_phenoty1.72536030
35MP0000343_altered_response_to1.69824552
36MP0008469_abnormal_protein_level1.64524470
37MP0005646_abnormal_pituitary_gland1.63920202
38MP0001853_heart_inflammation1.60035274
39MP0005671_abnormal_response_to1.56672569
40MP0005409_darkened_coat_color1.53487480
41MP0008569_lethality_at_weaning1.50986846
42MP0008961_abnormal_basal_metabolism1.50469380
43MP0003300_gastrointestinal_ulcer1.49065860
44MP0002138_abnormal_hepatobiliary_system1.49000148
45MP0000685_abnormal_immune_system1.46213021
46MP0002332_abnormal_exercise_endurance1.45146684
47MP0004811_abnormal_neuron_physiology1.42093541
48* MP0003075_altered_response_to1.40549348
49MP0003448_altered_tumor_morphology1.39755401
50MP0008872_abnormal_physiological_respon1.38307275
51MP0001835_abnormal_antigen_presentation1.35281476
52MP0002998_abnormal_bone_remodeling1.34866889
53* MP0008874_decreased_physiological_sensi1.34122606
54MP0001545_abnormal_hematopoietic_system1.33551140
55MP0005397_hematopoietic_system_phenotyp1.33551140
56MP0003453_abnormal_keratinocyte_physiol1.32313516
57MP0000858_altered_metastatic_potential1.31707682
58MP0002429_abnormal_blood_cell1.24118348
59MP0006054_spinal_hemorrhage1.23686423
60MP0000689_abnormal_spleen_morphology1.22527480
61MP0003633_abnormal_nervous_system1.22367336
62MP0002734_abnormal_mechanical_nocicepti1.21719444
63MP0006082_CNS_inflammation1.20514245
64* MP0001970_abnormal_pain_threshold1.18875416
65MP0002722_abnormal_immune_system1.18732178
66MP0005000_abnormal_immune_tolerance1.18181684
67MP0000013_abnormal_adipose_tissue1.17792589
68MP0005310_abnormal_salivary_gland1.17449383
69MP0003191_abnormal_cellular_cholesterol1.17321831
70MP0003806_abnormal_nucleotide_metabolis1.16442995
71MP0003656_abnormal_erythrocyte_physiolo1.16369652
72MP0009785_altered_susceptibility_to1.14816455
73MP0005535_abnormal_body_temperature1.12843396
74MP0003195_calcinosis1.09032569
75MP0001790_abnormal_immune_system1.08707140
76MP0005387_immune_system_phenotype1.08707140
77MP0003866_abnormal_defecation1.06533835
78MP0004858_abnormal_nervous_system1.06439870
79MP0003879_abnormal_hair_cell1.06280528
80MP0000569_abnormal_digit_pigmentation1.06224750
81MP0001348_abnormal_lacrimal_gland1.05470911
82MP0010234_abnormal_vibrissa_follicle1.04373324
83* MP0002557_abnormal_social/conspecific_i1.03462834
84MP0003329_amyloid_beta_deposits1.03212227
85MP0009763_increased_sensitivity_to1.02080176
86MP0002736_abnormal_nociception_after1.01387067
87MP0003690_abnormal_glial_cell1.00503982
88MP0001800_abnormal_humoral_immune0.99956864
89MP0001188_hyperpigmentation0.98481267
90MP0001984_abnormal_olfaction0.97679964
91MP0000465_gastrointestinal_hemorrhage0.96347769
92MP0000604_amyloidosis0.94934376
93MP0001663_abnormal_digestive_system0.93840343
94* MP0002723_abnormal_immune_serum0.93805095
95* MP0002733_abnormal_thermal_nociception0.93144575
96MP0009765_abnormal_xenobiotic_induced0.92480147
97MP0009780_abnormal_chondrocyte_physiolo0.91967798
98MP0001440_abnormal_grooming_behavior0.91205475
99* MP0002066_abnormal_motor_capabilities/c0.89811071
100MP0001819_abnormal_immune_cell0.89346610
101MP0003091_abnormal_cell_migration0.88775585
102MP0002420_abnormal_adaptive_immunity0.88390633
103MP0002254_reproductive_system_inflammat0.85932403
104MP0000920_abnormal_myelination0.85662723
105MP0005164_abnormal_response_to0.85639784
106MP0002067_abnormal_sensory_capabilities0.85258530
107MP0003283_abnormal_digestive_organ0.85194936
108MP0002452_abnormal_antigen_presenting0.85171387
109MP0001905_abnormal_dopamine_level0.85082694
110MP0005025_abnormal_response_to0.84186616
111MP0002148_abnormal_hypersensitivity_rea0.84186433
112MP0002933_joint_inflammation0.83217613
113MP0004885_abnormal_endolymph0.82266680
114MP0000703_abnormal_thymus_morphology0.82121815
115MP0005390_skeleton_phenotype0.81231799
116MP0003763_abnormal_thymus_physiology0.80146779
117MP0001873_stomach_inflammation0.79701817
118MP0003631_nervous_system_phenotype0.79683648
119MP0001177_atelectasis0.78816313
120MP0003646_muscle_fatigue0.78050618
121MP0002419_abnormal_innate_immunity0.77761932
122MP0008260_abnormal_autophagy0.77336631
123MP0002006_tumorigenesis0.76279565
124MP0003172_abnormal_lysosome_physiology0.76068022
125MP0003183_abnormal_peptide_metabolism0.75747400
126MP0001502_abnormal_circadian_rhythm0.75021044
127* MP0005464_abnormal_platelet_physiology0.74204040
128MP0003436_decreased_susceptibility_to0.74200206
129MP0004947_skin_inflammation0.73888567
130MP0002277_abnormal_respiratory_mucosa0.73826331
131MP0001851_eye_inflammation0.70311764
132MP0004808_abnormal_hematopoietic_stem0.70205778
133MP0002398_abnormal_bone_marrow0.69955560
134MP0003828_pulmonary_edema0.69019858
135MP0000249_abnormal_blood_vessel0.68714250
136MP0000716_abnormal_immune_system0.68577750
137MP0000955_abnormal_spinal_cord0.68277195
138MP0005165_increased_susceptibility_to0.68013332
139MP0002184_abnormal_innervation0.67565068
140MP0010155_abnormal_intestine_physiology0.66543549
141* MP0005166_decreased_susceptibility_to0.65444416
142* MP0002069_abnormal_eating/drinking_beha0.65287661
143* MP0004085_abnormal_heartbeat0.64866471
144MP0002735_abnormal_chemical_nociception0.64320685
145MP0003045_fibrosis0.61688278
146MP0004130_abnormal_muscle_cell0.61515974
147MP0004883_abnormal_blood_vessel0.61235769
148MP0002166_altered_tumor_susceptibility0.61234487
149MP0005584_abnormal_enzyme/coenzyme_acti0.60976874
150MP0002882_abnormal_neuron_morphology0.60352593
151MP0002693_abnormal_pancreas_physiology0.58954986
152MP0003795_abnormal_bone_structure0.57313961
153MP0000609_abnormal_liver_physiology0.55862986
154MP0002877_abnormal_melanocyte_morpholog0.54668297
155MP0005647_abnormal_sex_gland0.54542949
156MP0005381_digestive/alimentary_phenotyp0.53548898
157MP0000490_abnormal_crypts_of0.52664771
158MP0001542_abnormal_bone_strength0.51054389

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)8.58155266
2Focal motor seizures (HP:0011153)5.79794952
3Abnormality of macrophages (HP:0004311)5.28307732
4Retrobulbar optic neuritis (HP:0100654)5.20898525
5Optic neuritis (HP:0100653)5.20898525
6Abnormality of liposaccharide metabolism (HP:0010968)5.15554833
7Abnormality of glycosphingolipid metabolism (HP:0004343)5.15554833
8Abnormality of glycolipid metabolism (HP:0010969)5.15554833
9Orchitis (HP:0100796)5.11678179
10Annular pancreas (HP:0001734)4.91923924
11Myositis (HP:0100614)4.83028247
12Recurrent bacterial skin infections (HP:0005406)4.74672929
13Resting tremor (HP:0002322)4.68051335
14Recurrent abscess formation (HP:0002722)4.50458723
15Focal seizures (HP:0007359)4.34288776
16Torticollis (HP:0000473)4.29681150
17Polygenic inheritance (HP:0010982)3.79994271
18Ankyloglossia (HP:0010296)3.66802201
19Poor eye contact (HP:0000817)3.65311453
20Keratoconjunctivitis sicca (HP:0001097)3.64924688
21Craniofacial dystonia (HP:0012179)3.58686417
22Focal dystonia (HP:0004373)3.58037094
23Vasculitis (HP:0002633)3.55979564
24Loss of speech (HP:0002371)3.53611563
25Increased cerebral lipofuscin (HP:0011813)3.52894231
26Recurrent gram-negative bacterial infections (HP:0005420)3.51683202
27Vacuolated lymphocytes (HP:0001922)3.50826790
28Autoimmune thrombocytopenia (HP:0001973)3.50353999
29Increased IgM level (HP:0003496)3.48218197
30Anxiety (HP:0000739)3.47527698
31Systemic lupus erythematosus (HP:0002725)3.44408433
32Dysostosis multiplex (HP:0000943)3.42094796
33Ankle clonus (HP:0011448)3.38756256
34Impaired social interactions (HP:0000735)3.35706363
35Abnormal social behavior (HP:0012433)3.35706363
36Atrioventricular block (HP:0001678)3.35153622
37Keratoconjunctivitis (HP:0001096)3.34795257
38Pointed chin (HP:0000307)3.28866157
39Depression (HP:0000716)3.25813340
40Lower limb amyotrophy (HP:0007210)3.24672446
41Chronic obstructive pulmonary disease (HP:0006510)3.22205272
42Obstructive lung disease (HP:0006536)3.22205272
43Limb hypertonia (HP:0002509)3.21475388
44T lymphocytopenia (HP:0005403)3.21139633
45Impaired vibration sensation in the lower limbs (HP:0002166)3.20389025
46Disinhibition (HP:0000734)3.18403551
47Visual hallucinations (HP:0002367)3.16728435
48Pulmonary infiltrates (HP:0002113)3.16242428
49Action tremor (HP:0002345)3.15324562
50Recurrent fungal infections (HP:0002841)3.14043927
51Gastrointestinal infarctions (HP:0005244)3.12837965
52Stereotypic behavior (HP:0000733)3.12700745
53Meningitis (HP:0001287)3.11866430
54Axonal loss (HP:0003447)3.09858825
55Abnormality of oral frenula (HP:0000190)3.08059384
56Recurrent viral infections (HP:0004429)3.07607931
57Encephalitis (HP:0002383)3.03570293
58Gangrene (HP:0100758)3.02309207
59Increased IgE level (HP:0003212)3.01446360
60Papilledema (HP:0001085)3.00033369
61Prolonged QT interval (HP:0001657)2.99267785
62Abnormality of T cell number (HP:0011839)2.98381156
63Dysmetric saccades (HP:0000641)2.94318744
64Hemiplegia (HP:0002301)2.88921183
65Increased neuronal autofluorescent lipopigment (HP:0002074)2.88732030
66Urinary bladder sphincter dysfunction (HP:0002839)2.87938655
67Increased serum ferritin (HP:0003281)2.87293479
68Distal lower limb amyotrophy (HP:0008944)2.86860593
69Urinary urgency (HP:0000012)2.85332190
70Hemoptysis (HP:0002105)2.84628301
71Purpura (HP:0000979)2.84368089
72Petechiae (HP:0000967)2.84021613
73Autoimmune hemolytic anemia (HP:0001890)2.83023837
74Recurrent skin infections (HP:0001581)2.82704513
75Abnormality of the periventricular white matter (HP:0002518)2.77807102
76Broad-based gait (HP:0002136)2.76119492
77Upper limb amyotrophy (HP:0009129)2.70343260
78Distal upper limb amyotrophy (HP:0007149)2.70343260
79Gastrointestinal stroma tumor (HP:0100723)2.68729491
80Heart block (HP:0012722)2.68167554
81Hematochezia (HP:0002573)2.62255467
82Episodic fever (HP:0001954)2.61092569
83Dysdiadochokinesis (HP:0002075)2.59365850
84Arterial thrombosis (HP:0004420)2.57876397
85Chronic otitis media (HP:0000389)2.52709507
86Abnormality of mucopolysaccharide metabolism (HP:0011020)2.52650473
87Abnormality of polysaccharide metabolism (HP:0011012)2.52650473
88Abnormality of glycosaminoglycan metabolism (HP:0004371)2.52650473
89Nuclear cataract (HP:0100018)2.50785674
90Abnormal EKG (HP:0003115)2.50325467
91Urticaria (HP:0001025)2.49593288
92Spontaneous hematomas (HP:0007420)2.48997839
93Anorexia (HP:0002039)2.48945226
94Hypergammaglobulinemia (HP:0010702)2.48599397
95Truncal ataxia (HP:0002078)2.47923495
96Leukocytosis (HP:0001974)2.44359929
97Abnormal delayed hypersensitivity skin test (HP:0002963)2.44275851
98Spinal canal stenosis (HP:0003416)2.43488617
99Amyloidosis (HP:0011034)2.43294138
100Generalized tonic-clonic seizures (HP:0002069)2.43167536
101Supranuclear gaze palsy (HP:0000605)2.42935190
102Gaze-evoked nystagmus (HP:0000640)2.42890216
103Dysmetria (HP:0001310)2.41587446
104Polyneuropathy (HP:0001271)2.40514091
105Progressive inability to walk (HP:0002505)2.39648062
106Interstitial pulmonary disease (HP:0006530)2.39621289
107Abnormal atrioventricular conduction (HP:0005150)2.39490590
108Joint swelling (HP:0001386)2.36927157
109Pulmonary embolism (HP:0002204)2.35279748
110Abnormality of the pleura (HP:0002103)2.34991425
111Gingivitis (HP:0000230)2.34840340
112Abnormality of iron homeostasis (HP:0011031)2.34042080
113Postural instability (HP:0002172)2.33794542
114Lymphopenia (HP:0001888)2.33040972
115Mucopolysacchariduria (HP:0008155)2.31751434
116Urinary glycosaminoglycan excretion (HP:0003541)2.31751434
117Progressive neurologic deterioration (HP:0002344)2.30591987
118Acute lymphatic leukemia (HP:0006721)2.30572104
119Absence seizures (HP:0002121)2.28892432
120Prolonged bleeding time (HP:0003010)2.28423651
121Spastic gait (HP:0002064)2.24555066
122Scanning speech (HP:0002168)2.24408967
123Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.22598108
124Febrile seizures (HP:0002373)2.20770285
125Abnormality of T cells (HP:0002843)2.20662182
126Epileptic encephalopathy (HP:0200134)2.19524374
127Hepatosplenomegaly (HP:0001433)2.18688253
128Impaired smooth pursuit (HP:0007772)2.18432004
129Glomerulonephritis (HP:0000099)2.18378526
130Colitis (HP:0002583)2.18198990
131Neurofibrillary tangles (HP:0002185)2.16726938
132Epistaxis (HP:0000421)2.16367728
133Abnormal eating behavior (HP:0100738)2.16048089
134Fatigue (HP:0012378)2.15937860
135Abnormality of cells of the lymphoid lineage (HP:0012140)2.15882158
136Clonus (HP:0002169)2.14362223
137Chest pain (HP:0100749)2.14137485
138Abnormality of B cell number (HP:0010975)2.13360184
139IgA deficiency (HP:0002720)2.13272352
140Elevated erythrocyte sedimentation rate (HP:0003565)2.12174240
141Tetraplegia (HP:0002445)2.11369650
142Cellulitis (HP:0100658)2.11019342
143Stomatitis (HP:0010280)2.10244792
144Dialeptic seizures (HP:0011146)2.10132272
145Parakeratosis (HP:0001036)2.09680831
146Arthralgia (HP:0002829)2.09131931
147Chronic mucocutaneous candidiasis (HP:0002728)2.08449568
148Recurrent cutaneous fungal infections (HP:0011370)2.08449568
149Megalencephaly (HP:0001355)2.07721405
150Restrictive lung disease (HP:0002091)2.06188406
151Diminished motivation (HP:0000745)2.05760445
152B lymphocytopenia (HP:0010976)2.05388478
153Bradykinesia (HP:0002067)2.05086357
154Truncus arteriosus (HP:0001660)2.05048347
155Vertigo (HP:0002321)2.04941995
156Intention tremor (HP:0002080)2.04930657
157Nausea (HP:0002018)2.04296231
158Palpebral edema (HP:0100540)2.03709950
159Inflammation of the large intestine (HP:0002037)2.03187924
160Acne (HP:0001061)2.02990371
161Recurrent bronchitis (HP:0002837)2.02217313
162Abnormality of the vasculature of the conjunctiva (HP:0008054)2.02135383
163Limb dystonia (HP:0002451)2.01266987
164Deep palmar crease (HP:0006191)2.01139963
165Mediastinal lymphadenopathy (HP:0100721)1.99511095
166Impaired vibratory sensation (HP:0002495)1.99458706
167Combined immunodeficiency (HP:0005387)1.98713432
168Primary atrial arrhythmia (HP:0001692)1.97503888
169Abnormality of saccadic eye movements (HP:0000570)1.95885557
170Ventricular fibrillation (HP:0001663)1.94371939
171Atrial fibrillation (HP:0005110)1.91691227
172Bundle branch block (HP:0011710)1.89901317
173Mutism (HP:0002300)1.88433853
174Eczematoid dermatitis (HP:0000976)1.87145507
175Abnormality of the nasal mucosa (HP:0000433)1.86361838
176Supraventricular tachycardia (HP:0004755)1.85569963
177Neuronal loss in central nervous system (HP:0002529)1.85316279
178Obsessive-compulsive behavior (HP:0000722)1.82748627
179Nasal polyposis (HP:0100582)1.82746650
180Striae distensae (HP:0001065)1.82220052
181Lower limb muscle weakness (HP:0007340)1.81850627
182Onion bulb formation (HP:0003383)1.81326023
183Atonic seizures (HP:0010819)1.80712419
184Lower limb asymmetry (HP:0100559)1.80640080
185Polycythemia (HP:0001901)1.80258940
186Supraventricular arrhythmia (HP:0005115)1.79340808
187Ocular albinism (HP:0001107)1.77368840
188Hemiparesis (HP:0001269)1.77284063
189Abnormality of ocular smooth pursuit (HP:0000617)1.77094999
190Obstructive sleep apnea (HP:0002870)1.73335177
191Apathy (HP:0000741)1.73232923
192Porencephaly (HP:0002132)1.72971140
193Dysphonia (HP:0001618)1.71527937

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA47.70140752
2IRAK34.95129384
3RIPK43.24406713
4MAP3K133.14488096
5MAP3K93.09955819
6KSR23.00250715
7NTRK32.93808986
8IRAK42.82642950
9MATK2.67885920
10TAOK22.61600436
11NME22.59846294
12FES2.55621185
13GRK72.47277993
14DAPK22.47069030
15BLK2.34824243
16PRKD32.24346301
17CSK2.24316219
18CAMKK12.19642198
19MAP3K112.17520563
20TAOK12.17511760
21DDR22.10107541
22FGR1.99041324
23TRIB31.94499423
24ERN11.88282773
25MAP2K31.84435220
26ARAF1.82913932
27MAP3K31.75667597
28SIK21.72211240
29NTRK11.48329420
30RAF11.43685689
31MAP3K21.42929930
32TYRO31.42543486
33NTRK21.40638337
34PRKCH1.38589684
35KSR11.38122805
36CDK51.37477815
37IKBKE1.36908337
38MINK11.34706314
39MAP4K11.33763696
40CHUK1.31369216
41IRAK11.29526100
42CDC42BPA1.27928488
43SIK31.25554134
44LYN1.24981031
45DAPK11.24730301
46CAMKK21.24710502
47JAK11.23303806
48BTK1.22798968
49RIPK11.22214573
50PIM21.21466037
51IRAK21.21210561
52BMPR21.19976894
53MAP3K141.18983715
54PAK61.16720463
55MAP3K11.11533248
56SGK31.06384314
57RET1.05348104
58ALK1.04696431
59JAK31.02919208
60HCK1.02383621
61ADRBK21.00542024
62LCK0.98810825
63TBK10.98079458
64TAOK30.96324857
65MARK20.95439069
66CSF1R0.95297277
67TNIK0.93643128
68TXK0.92700467
69SGK20.90518501
70TGFBR20.88848690
71TESK20.88791428
72PDK10.87719411
73PRKD20.86265297
74SGK2230.83267755
75SGK4940.83267755
76SGK10.82896498
77PDPK10.82341597
78MAP3K50.81042560
79MAP3K40.80231869
80STK110.78354343
81STK100.77444277
82IKBKB0.75478109
83EPHA30.74020349
84TYK20.72816986
85DMPK0.71393228
86PRPF4B0.69699701
87TNK20.68959602
88PIM10.68635278
89SYK0.68357123
90ACVR1B0.66208138
91PTK2B0.64180370
92PINK10.62776367
93JAK20.62062155
94FYN0.57846061
95SIK10.57425254
96EPHB10.55017006
97KIT0.54900190
98PRKCQ0.54680162
99MAP3K70.53438900
100CAMK10.52635417
101MARK30.51781737
102FGFR30.51341946
103STK380.50868032
104BMX0.50588086
105MARK10.50052922
106ABL20.49355002
107CAMK40.48750633
108DAPK30.48174938
109TEC0.47143617
110MOS0.46879773
111MAP2K60.46685590
112CLK10.46334930
113MAP2K10.45173635
114CDK150.44239976
115ZAP700.44207498
116RPS6KA30.43739917
117SCYL20.42936152
118CDK180.42502273
119UHMK10.41211627
120PRKCZ0.40529584
121PKN20.40415127
122CDK140.40396212
123MAP2K70.39508028
124MAPK40.39377018
125CDK11A0.37491431
126LRRK20.37204395
127MAP2K40.35665410
128MAPK70.35409155
129MAPK100.34335507
130DYRK30.33890842
131LMTK20.33686960
132CDK40.32718842
133FGFR40.32282209
134PKN10.31724956
135GRK60.30990386
136ITK0.30377450
137CAMK2A0.30356290
138RPS6KC10.30057247
139RPS6KL10.30057247
140HIPK20.29535944
141PRKACG0.29507000
142KDR0.29355420
143NEK10.29069327
144SMG10.28428373
145PDGFRA0.28057526
146PRKCG0.28033931
147PRKCB0.27426995
148INSR0.27416377
149PDGFRB0.26088342
150NLK0.25930467
151MAPK120.25252459
152ABL10.25187728
153CDK60.22590492
154RPS6KA60.22363235
155DYRK1B0.21477890
156MAPKAPK20.20029001

Predicted pathways (KEGG)

RankGene SetZ-score
1Olfactory transduction_Homo sapiens_hsa047403.44170444
2Cocaine addiction_Homo sapiens_hsa050302.59772233
3Morphine addiction_Homo sapiens_hsa050322.58160783
4Rheumatoid arthritis_Homo sapiens_hsa053232.43479312
5Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.36865505
6Malaria_Homo sapiens_hsa051442.35438336
7Staphylococcus aureus infection_Homo sapiens_hsa051502.35124999
8Asthma_Homo sapiens_hsa053102.28573264
9Circadian entrainment_Homo sapiens_hsa047132.21867718
10Amphetamine addiction_Homo sapiens_hsa050312.20019425
11Intestinal immune network for IgA production_Homo sapiens_hsa046722.19783735
12GABAergic synapse_Homo sapiens_hsa047272.15345674
13Legionellosis_Homo sapiens_hsa051342.12761903
14Long-term potentiation_Homo sapiens_hsa047202.05873136
15Cholinergic synapse_Homo sapiens_hsa047252.03490266
16Dopaminergic synapse_Homo sapiens_hsa047281.98016854
17Type I diabetes mellitus_Homo sapiens_hsa049401.93588581
18Glutamatergic synapse_Homo sapiens_hsa047241.93228980
19Other glycan degradation_Homo sapiens_hsa005111.92934245
20Pertussis_Homo sapiens_hsa051331.88357160
21Renin secretion_Homo sapiens_hsa049241.82026047
22Synaptic vesicle cycle_Homo sapiens_hsa047211.80478659
23Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.79347608
24Influenza A_Homo sapiens_hsa051641.75943753
25Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.69175156
26Nicotine addiction_Homo sapiens_hsa050331.68805230
27Hematopoietic cell lineage_Homo sapiens_hsa046401.67123358
28Aldosterone synthesis and secretion_Homo sapiens_hsa049251.60256057
29Salivary secretion_Homo sapiens_hsa049701.57287683
30Oxytocin signaling pathway_Homo sapiens_hsa049211.55864098
31Lysosome_Homo sapiens_hsa041421.51869365
32Antigen processing and presentation_Homo sapiens_hsa046121.51474039
33Herpes simplex infection_Homo sapiens_hsa051681.48874285
34Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.48493934
35Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.48299600
36Gastric acid secretion_Homo sapiens_hsa049711.42570678
37Nitrogen metabolism_Homo sapiens_hsa009101.42164189
38Graft-versus-host disease_Homo sapiens_hsa053321.40291161
39Allograft rejection_Homo sapiens_hsa053301.39090551
40Viral myocarditis_Homo sapiens_hsa054161.37392388
41Chemokine signaling pathway_Homo sapiens_hsa040621.34924495
42Jak-STAT signaling pathway_Homo sapiens_hsa046301.32813020
43Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.30270521
44Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.28164809
45Gap junction_Homo sapiens_hsa045401.27735255
46GnRH signaling pathway_Homo sapiens_hsa049121.25152958
47Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.21019207
48* Calcium signaling pathway_Homo sapiens_hsa040201.20505847
49Hepatitis C_Homo sapiens_hsa051601.19146088
50Insulin secretion_Homo sapiens_hsa049111.18866707
51Hepatitis B_Homo sapiens_hsa051611.14653249
52Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.14590144
53Shigellosis_Homo sapiens_hsa051311.14566245
54* cAMP signaling pathway_Homo sapiens_hsa040241.13522985
55Non-small cell lung cancer_Homo sapiens_hsa052231.13017733
56Type II diabetes mellitus_Homo sapiens_hsa049301.12528324
57Serotonergic synapse_Homo sapiens_hsa047261.09443342
58Glioma_Homo sapiens_hsa052141.08251269
59T cell receptor signaling pathway_Homo sapiens_hsa046601.07707415
60Neurotrophin signaling pathway_Homo sapiens_hsa047221.07215219
61B cell receptor signaling pathway_Homo sapiens_hsa046621.06491954
62Osteoclast differentiation_Homo sapiens_hsa043801.05820924
63Long-term depression_Homo sapiens_hsa047301.04446835
64Glycosaminoglycan degradation_Homo sapiens_hsa005311.02345291
65Phagosome_Homo sapiens_hsa041451.01888576
66Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.01131564
67Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.00546246
68Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.99644100
69Phospholipase D signaling pathway_Homo sapiens_hsa040720.99532402
70Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.98327162
71Apoptosis_Homo sapiens_hsa042100.98270773
72Phosphatidylinositol signaling system_Homo sapiens_hsa040700.97020828
73VEGF signaling pathway_Homo sapiens_hsa043700.96129135
74Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.94343430
75Leishmaniasis_Homo sapiens_hsa051400.92041203
76Estrogen signaling pathway_Homo sapiens_hsa049150.88946290
77cGMP-PKG signaling pathway_Homo sapiens_hsa040220.88759059
78Dorso-ventral axis formation_Homo sapiens_hsa043200.88471553
79African trypanosomiasis_Homo sapiens_hsa051430.88185975
80Epstein-Barr virus infection_Homo sapiens_hsa051690.88128331
81Platelet activation_Homo sapiens_hsa046110.87541184
82Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.85231159
83Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.82898264
84MAPK signaling pathway_Homo sapiens_hsa040100.82817769
85Bladder cancer_Homo sapiens_hsa052190.82540273
86TNF signaling pathway_Homo sapiens_hsa046680.79964190
87Dilated cardiomyopathy_Homo sapiens_hsa054140.79886388
88ErbB signaling pathway_Homo sapiens_hsa040120.78864809
89Taste transduction_Homo sapiens_hsa047420.78010485
90Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.76618302
91Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.75457250
92Amoebiasis_Homo sapiens_hsa051460.75386058
93Toll-like receptor signaling pathway_Homo sapiens_hsa046200.75250339
94Chronic myeloid leukemia_Homo sapiens_hsa052200.74719145
95Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.72474284
96Prolactin signaling pathway_Homo sapiens_hsa049170.71180720
97Thyroid hormone signaling pathway_Homo sapiens_hsa049190.69934129
98* Rap1 signaling pathway_Homo sapiens_hsa040150.69724812
99Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.69563255
100mTOR signaling pathway_Homo sapiens_hsa041500.69086964
101Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.68136026
102Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.67161656
103Sphingolipid signaling pathway_Homo sapiens_hsa040710.66367579
104Adipocytokine signaling pathway_Homo sapiens_hsa049200.64878914
105Autoimmune thyroid disease_Homo sapiens_hsa053200.64110135
106* Vascular smooth muscle contraction_Homo sapiens_hsa042700.63824954
107Endocytosis_Homo sapiens_hsa041440.60711661
108Tuberculosis_Homo sapiens_hsa051520.60194000
109Choline metabolism in cancer_Homo sapiens_hsa052310.59788937
110* Alcoholism_Homo sapiens_hsa050340.58779542
111AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.58111520
112Melanogenesis_Homo sapiens_hsa049160.57825357
113Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.57362862
114HTLV-I infection_Homo sapiens_hsa051660.54441630
115NOD-like receptor signaling pathway_Homo sapiens_hsa046210.54163809
116Carbohydrate digestion and absorption_Homo sapiens_hsa049730.53585031
117NF-kappa B signaling pathway_Homo sapiens_hsa040640.52605226
118Acute myeloid leukemia_Homo sapiens_hsa052210.52525224
119Longevity regulating pathway - mammal_Homo sapiens_hsa042110.52453799
120RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.51890991
121Endometrial cancer_Homo sapiens_hsa052130.51324203
122Salmonella infection_Homo sapiens_hsa051320.51252345
123Toxoplasmosis_Homo sapiens_hsa051450.50545853
124Complement and coagulation cascades_Homo sapiens_hsa046100.50269960
125Pancreatic cancer_Homo sapiens_hsa052120.50024629
126Renal cell carcinoma_Homo sapiens_hsa052110.49612837
127SNARE interactions in vesicular transport_Homo sapiens_hsa041300.48973946
128Leukocyte transendothelial migration_Homo sapiens_hsa046700.48670288
129Measles_Homo sapiens_hsa051620.48607618
130Prion diseases_Homo sapiens_hsa050200.48511807
131Primary immunodeficiency_Homo sapiens_hsa053400.48454808
132Viral carcinogenesis_Homo sapiens_hsa052030.48452170
133Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.48073000
134Thyroid cancer_Homo sapiens_hsa052160.48033281
135Pancreatic secretion_Homo sapiens_hsa049720.47956132
136Ras signaling pathway_Homo sapiens_hsa040140.47893132
137Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.47865973
138Collecting duct acid secretion_Homo sapiens_hsa049660.47838877
139Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.47491881
140Notch signaling pathway_Homo sapiens_hsa043300.47005898
141Transcriptional misregulation in cancer_Homo sapiens_hsa052020.44164218
142Sphingolipid metabolism_Homo sapiens_hsa006000.40128754
143Systemic lupus erythematosus_Homo sapiens_hsa053220.37504355
144HIF-1 signaling pathway_Homo sapiens_hsa040660.35377994
145Insulin resistance_Homo sapiens_hsa049310.29678655
146FoxO signaling pathway_Homo sapiens_hsa040680.29249838
147Small cell lung cancer_Homo sapiens_hsa052220.13974489
148Vibrio cholerae infection_Homo sapiens_hsa051100.13514693
149Sulfur metabolism_Homo sapiens_hsa009200.13275714
150Prostate cancer_Homo sapiens_hsa052150.12209013
151Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.11257266
152Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.10449333
153Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.08642036

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