ADHFE1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The ADHFE1 gene encodes hydroxyacid-oxoacid transhydrogenase (EC 1.1.99.24), which is responsible for the oxidation of 4-hydroxybutyrate in mammalian tissues (Kardon et al., 2006 [PubMed 16616524]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.55406492
2L-phenylalanine catabolic process (GO:0006559)6.55406492
3L-phenylalanine metabolic process (GO:0006558)6.31136709
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.31136709
5aromatic amino acid family catabolic process (GO:0009074)5.92552255
6lysine metabolic process (GO:0006553)5.79821164
7lysine catabolic process (GO:0006554)5.79821164
8glyoxylate metabolic process (GO:0046487)5.60027527
9actin-myosin filament sliding (GO:0033275)5.54798758
10muscle filament sliding (GO:0030049)5.54798758
11cysteine metabolic process (GO:0006534)5.53531813
12alpha-linolenic acid metabolic process (GO:0036109)5.42422953
13tryptophan catabolic process (GO:0006569)5.39417902
14indole-containing compound catabolic process (GO:0042436)5.39417902
15indolalkylamine catabolic process (GO:0046218)5.39417902
16triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.26931790
17kynurenine metabolic process (GO:0070189)5.19445885
18fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)5.19043527
19sulfur amino acid catabolic process (GO:0000098)5.17405619
20tryptophan metabolic process (GO:0006568)5.07713612
21bile acid biosynthetic process (GO:0006699)4.96351512
22regulation of relaxation of muscle (GO:1901077)4.90931569
23regulation of skeletal muscle contraction (GO:0014819)4.90661913
24homocysteine metabolic process (GO:0050667)4.86097654
25serine family amino acid catabolic process (GO:0009071)4.82104809
26amino-acid betaine metabolic process (GO:0006577)4.78641637
27short-chain fatty acid metabolic process (GO:0046459)4.68521638
28sarcoplasmic reticulum calcium ion transport (GO:0070296)4.66819821
29valine metabolic process (GO:0006573)4.57555036
30cellular ketone body metabolic process (GO:0046950)4.57483573
31fatty acid beta-oxidation (GO:0006635)4.51270586
32alpha-amino acid catabolic process (GO:1901606)4.48335056
33urea metabolic process (GO:0019627)4.45974769
34urea cycle (GO:0000050)4.45974769
35acetyl-CoA metabolic process (GO:0006084)4.44071901
36aspartate family amino acid catabolic process (GO:0009068)4.42013665
37actin-mediated cell contraction (GO:0070252)4.41825207
38regulation of triglyceride catabolic process (GO:0010896)4.40461206
39complement activation, alternative pathway (GO:0006957)4.35092311
40cellular modified amino acid catabolic process (GO:0042219)4.32036762
41fatty acid oxidation (GO:0019395)4.31117721
42cellular amino acid catabolic process (GO:0009063)4.30355335
43aromatic amino acid family metabolic process (GO:0009072)4.29685336
44lipid oxidation (GO:0034440)4.26857257
45regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)4.23734291
46urate metabolic process (GO:0046415)4.20469069
47branched-chain amino acid catabolic process (GO:0009083)4.19744516
48bile acid metabolic process (GO:0008206)4.16547472
49nitrogen cycle metabolic process (GO:0071941)4.16517196
50high-density lipoprotein particle remodeling (GO:0034375)4.16149751
51drug transmembrane transport (GO:0006855)4.14866742
52positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)4.13175869
53fatty acid catabolic process (GO:0009062)4.13045441
54glutamate metabolic process (GO:0006536)4.12097720
55branched-chain amino acid metabolic process (GO:0009081)4.09604793
56tyrosine metabolic process (GO:0006570)4.05885674
57ethanol oxidation (GO:0006069)4.04781286
58epoxygenase P450 pathway (GO:0019373)4.04370024
59protein carboxylation (GO:0018214)4.02836454
60peptidyl-glutamic acid carboxylation (GO:0017187)4.02836454
61monocarboxylic acid catabolic process (GO:0072329)4.02409095
62serine family amino acid metabolic process (GO:0009069)4.01610132
63regulation of protein activation cascade (GO:2000257)3.99994894
64carnitine metabolic process (GO:0009437)3.99600398
65ketone body metabolic process (GO:1902224)3.98526525
66organic acid catabolic process (GO:0016054)3.98109148
67carboxylic acid catabolic process (GO:0046395)3.98109148
68creatine metabolic process (GO:0006600)3.97523733
69* 2-oxoglutarate metabolic process (GO:0006103)3.97361464
70negative regulation of fibrinolysis (GO:0051918)3.97037058
71drug catabolic process (GO:0042737)3.94156644
72coenzyme catabolic process (GO:0009109)3.93587903
73biotin metabolic process (GO:0006768)3.93215545
74acylglycerol homeostasis (GO:0055090)3.90075736
75triglyceride homeostasis (GO:0070328)3.90075736
76reverse cholesterol transport (GO:0043691)3.88632688
77myofibril assembly (GO:0030239)3.88292150
78dicarboxylic acid biosynthetic process (GO:0043650)3.87370223
79positive regulation of fatty acid beta-oxidation (GO:0032000)3.83421197
80plasma lipoprotein particle clearance (GO:0034381)3.81090584
81regulation of fibrinolysis (GO:0051917)3.80165948
82regulation of complement activation (GO:0030449)3.77885430
83serine family amino acid biosynthetic process (GO:0009070)3.77066187
84indolalkylamine metabolic process (GO:0006586)3.76539994
85protein-lipid complex remodeling (GO:0034368)3.76519276
86macromolecular complex remodeling (GO:0034367)3.76519276
87plasma lipoprotein particle remodeling (GO:0034369)3.76519276
88skeletal muscle contraction (GO:0003009)3.75551042
89regulation of cholesterol esterification (GO:0010872)3.71772970
90amine catabolic process (GO:0009310)3.71097294
91cellular biogenic amine catabolic process (GO:0042402)3.71097294
92benzene-containing compound metabolic process (GO:0042537)3.68056263
93cellular glucuronidation (GO:0052695)3.64118506
94fatty acid transmembrane transport (GO:1902001)3.63029073
95negative regulation of cholesterol transport (GO:0032375)3.61086609
96negative regulation of sterol transport (GO:0032372)3.61086609
97glycine metabolic process (GO:0006544)3.60989975
98tricarboxylic acid metabolic process (GO:0072350)3.58158680
99exogenous drug catabolic process (GO:0042738)3.57793097
100positive regulation of lipid catabolic process (GO:0050996)3.57447671
101positive regulation of fatty acid oxidation (GO:0046321)3.51741996
102phospholipid homeostasis (GO:0055091)3.51448337
103regulation of cholesterol homeostasis (GO:2000188)3.49149174
104drug transport (GO:0015893)3.46407240
105omega-hydroxylase P450 pathway (GO:0097267)3.46217047
106regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.44055615
107regulation of sequestering of triglyceride (GO:0010889)3.43645782
108response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.41458802
109phospholipid efflux (GO:0033700)3.41128926
110regulation of actin filament-based movement (GO:1903115)3.38256760
111small molecule catabolic process (GO:0044282)3.35828633
112striated muscle contraction (GO:0006941)3.35705367
113carnitine transport (GO:0015879)3.33581788
114amino-acid betaine transport (GO:0015838)3.33581788
115carnitine transmembrane transport (GO:1902603)3.32867251
116regulation of cholesterol metabolic process (GO:0090181)3.32428247
117carnitine shuttle (GO:0006853)3.31358096
118sarcomere organization (GO:0045214)3.30484749
119regulation of bile acid biosynthetic process (GO:0070857)3.30430962
120uronic acid metabolic process (GO:0006063)3.29922089
121glucuronate metabolic process (GO:0019585)3.29922089
122cardiac myofibril assembly (GO:0055003)3.29811861
123negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.29737671
124ethanol metabolic process (GO:0006067)3.29345744
125oxidative demethylation (GO:0070989)3.27629499
126regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.26011180
127blood coagulation, intrinsic pathway (GO:0007597)3.21104557
128regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.18530517
129regulation of cell communication by electrical coupling (GO:0010649)3.12163266
130actin filament-based movement (GO:0030048)3.10061165
131cardiac muscle contraction (GO:0060048)3.06440397
132S-adenosylmethionine metabolic process (GO:0046500)3.03053062
133response to inactivity (GO:0014854)2.97720193
134oxaloacetate metabolic process (GO:0006107)2.95139909
135quaternary ammonium group transport (GO:0015697)2.94554459
136response to muscle activity (GO:0014850)2.93475256
137regulation of striated muscle contraction (GO:0006942)2.81373633
138glycogen catabolic process (GO:0005980)2.81198876
139negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.80474061
140negative regulation of calcium ion transmembrane transport (GO:1903170)2.80474061
141drug metabolic process (GO:0017144)2.80007371
142cellular polysaccharide catabolic process (GO:0044247)2.78561682
143xenobiotic catabolic process (GO:0042178)2.72207073
144regulation of germinal center formation (GO:0002634)2.70726230
145positive regulation of triglyceride lipase activity (GO:0061365)2.69504506
146positive regulation of lipoprotein lipase activity (GO:0051006)2.69504506
147response to mercury ion (GO:0046689)2.65705522
148NADH metabolic process (GO:0006734)2.64244016
149glucan catabolic process (GO:0009251)2.60567903
150cardiac muscle hypertrophy (GO:0003300)2.60398733
151muscle contraction (GO:0006936)2.57347627
152phenylpropanoid metabolic process (GO:0009698)2.57152807
153quinone biosynthetic process (GO:1901663)2.56774782
154heart contraction (GO:0060047)2.51781748
155heart process (GO:0003015)2.51781748
156striated muscle hypertrophy (GO:0014897)2.50269542
157positive regulation of gamma-delta T cell activation (GO:0046645)2.49697581
158negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.49261934
159negative regulation of T-helper cell differentiation (GO:0045623)2.49261934
160polysaccharide catabolic process (GO:0000272)2.48973535
161regulation of lipoprotein metabolic process (GO:0050746)2.46975265
162ubiquinone biosynthetic process (GO:0006744)2.46146802
163response to vitamin E (GO:0033197)2.44927269

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse7.35784391
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse7.07824373
3* PPARA_22158963_ChIP-Seq_LIVER_Mouse6.28598860
4LXR_22158963_ChIP-Seq_LIVER_Mouse5.82138827
5EGR1_23403033_ChIP-Seq_LIVER_Mouse5.36803346
6BP1_19119308_ChIP-ChIP_Hs578T_Human5.34588838
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.68185224
8CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.78656776
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.68399492
10* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.22462927
11CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.99137455
12CLOCK_20551151_ChIP-Seq_293T_Human2.27969914
13EZH2_22144423_ChIP-Seq_EOC_Human2.13766377
14TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.01973241
15ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.2756511
16RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.95849768
17LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.91975431
18HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.86840032
19FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.78517155
20RUNX_20019798_ChIP-Seq_JUKART_Human1.76508926
21GBX2_23144817_ChIP-Seq_PC3_Human1.69847237
22* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.66437999
23FOXA2_19822575_ChIP-Seq_HepG2_Human1.60017096
24ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.59803630
25IGF1R_20145208_ChIP-Seq_DFB_Human1.59106883
26E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.56896506
27SCL_19346495_ChIP-Seq_HPC-7_Human1.48722052
28RARG_19884340_ChIP-ChIP_MEFs_Mouse1.45548499
29VDR_22108803_ChIP-Seq_LS180_Human1.43797606
30THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.40099397
31GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.38433885
32HNF4A_19822575_ChIP-Seq_HepG2_Human1.33694738
33GATA1_22025678_ChIP-Seq_K562_Human1.33200800
34* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.28429225
35GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.28136031
36PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.26752016
37LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.25380183
38TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.23311369
39SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.17997969
40* EZH2_27294783_Chip-Seq_NPCs_Mouse1.15533083
41POU3F2_20337985_ChIP-ChIP_501MEL_Human1.15064416
42ESR2_21235772_ChIP-Seq_MCF-7_Human1.14879026
43* SUZ12_27294783_Chip-Seq_NPCs_Mouse1.13598004
44ER_23166858_ChIP-Seq_MCF-7_Human1.10288316
45* NFE2_27457419_Chip-Seq_LIVER_Mouse1.08707595
46BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.08429325
47HTT_18923047_ChIP-ChIP_STHdh_Human1.08298457
48ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.07895049
49* CRX_20693478_ChIP-Seq_RETINA_Mouse1.07814982
50ZFP57_27257070_Chip-Seq_ESCs_Mouse1.07668698
51PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.06690592
52PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.06263935
53TAF15_26573619_Chip-Seq_HEK293_Human1.05324629
54GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.04325644
55IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.98896669
56* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.98480134
57* OCT4_21477851_ChIP-Seq_ESCs_Mouse0.95906919
58SOX2_27498859_Chip-Seq_STOMACH_Mouse0.95420016
59* SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.93793422
60STAT1_20625510_ChIP-Seq_HELA_Human0.93279846
61EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.92274476
62RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.92050476
63* FLI1_27457419_Chip-Seq_LIVER_Mouse0.91458628
64ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.91200411
65TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.90826730
66SPI1_20517297_ChIP-Seq_HL60_Human0.90628576
67DROSHA_22980978_ChIP-Seq_HELA_Human0.90533685
68GATA2_21666600_ChIP-Seq_HMVEC_Human0.90361933
69AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.89914646
70RXRA_24833708_ChIP-Seq_LIVER_Mouse0.89332136
71GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.87996359
72AUTS2_25519132_ChIP-Seq_293T-REX_Human0.87330982
73PCGF2_27294783_Chip-Seq_NPCs_Mouse0.87235762
74NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.86839672
75NRF2_20460467_ChIP-Seq_MEFs_Mouse0.86839672
76NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.86801727
77CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.86485791
78NANOG_19829295_ChIP-Seq_ESCs_Human0.86396813
79SOX2_19829295_ChIP-Seq_ESCs_Human0.86396813
80TBX20_22080862_ChIP-Seq_HEART_Mouse0.85352005
81TBX20_22328084_ChIP-Seq_HEART_Mouse0.85352005
82HNFA_21074721_ChIP-Seq_CACO-2_Human0.85005967
83STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.84687344
84FOXA1_21572438_ChIP-Seq_LNCaP_Human0.84501587
85* GATA4_25053715_ChIP-Seq_YYC3_Human0.83608266
86PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.83561883
87IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.83455434
88* P53_22387025_ChIP-Seq_ESCs_Mouse0.83377216
89GATA3_27048872_Chip-Seq_THYMUS_Human0.82832126
90ESR1_20079471_ChIP-ChIP_T-47D_Human0.82709026
91ESR1_21235772_ChIP-Seq_MCF-7_Human0.82380397
92ETV2_25802403_ChIP-Seq_MESCs_Mouse0.82118719
93SMAD4_21799915_ChIP-Seq_A2780_Human0.81952115
94TRIM28_21343339_ChIP-Seq_HEK293_Human0.81921791
95CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.81590341
96CBP_20019798_ChIP-Seq_JUKART_Human0.81336837
97IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.81336837
98GATA6_21074721_ChIP-Seq_CACO-2_Human0.81292222
99GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.80568300
100GATA1_19941827_ChIP-Seq_MEL_Mouse0.80484023
101IKZF1_21737484_ChIP-ChIP_HCT116_Human0.79763370
102ZNF263_19887448_ChIP-Seq_K562_Human0.79426864
103NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.79418006
104MYB_26560356_Chip-Seq_TH2_Human0.79111181
105Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.78584423
106KLF5_20875108_ChIP-Seq_MESCs_Mouse0.78580457
107OCT4_20526341_ChIP-Seq_ESCs_Human0.78387953
108TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.78267764
109ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.78245492
110PPAR_26484153_Chip-Seq_NCI-H1993_Human0.77427506
111GATA3_21878914_ChIP-Seq_MCF-7_Human0.77313165
112IRF8_27001747_Chip-Seq_BMDM_Mouse0.77158336
113* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.77144595
114SALL4_18804426_ChIP-ChIP_XEN_Mouse0.77137437
115* PCGF2_27294783_Chip-Seq_ESCs_Mouse0.76637919
116PHF8_20622853_ChIP-Seq_HELA_Human0.76063345
117FOXO3_23340844_ChIP-Seq_DLD1_Human0.75629889
118SPI1_23127762_ChIP-Seq_K562_Human0.75111134
119FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.75106290
120AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.74268956
121SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.73047294
122BCAT_22108803_ChIP-Seq_LS180_Human0.71245714
123PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.70582888
124RAD21_21589869_ChIP-Seq_MESCs_Mouse0.70325842
125* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.69939136
126PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.69241972
127CDX2_20551321_ChIP-Seq_CACO-2_Human0.65575991
128EGR1_19032775_ChIP-ChIP_M12_Human0.63665975
129PIAS1_25552417_ChIP-Seq_VCAP_Human0.63576075
130LXR_22292898_ChIP-Seq_THP-1_Human0.63456827
131EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.61586786
132CDX2_19796622_ChIP-Seq_MESCs_Mouse0.61522818
133BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.61431142
134CEBPB_22108803_ChIP-Seq_LS180_Human0.61375713
135TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.60386729
136ERG_21242973_ChIP-ChIP_JURKAT_Human0.58522910
137FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.57628818
138CBP_21632823_ChIP-Seq_H3396_Human0.57286513
139PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.56726753
140AR_20517297_ChIP-Seq_VCAP_Human0.56314962
141EP300_21415370_ChIP-Seq_HL-1_Mouse0.56157856
142RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.55983961
143SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.55164342
144GATA2_19941826_ChIP-Seq_K562_Human0.53853177
145FOXA1_25552417_ChIP-Seq_VCAP_Human0.53841652
146ESR1_15608294_ChIP-ChIP_MCF-7_Human0.53640741
147SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.51741459
148CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.51214107
149IRF8_22096565_ChIP-ChIP_GC-B_Human0.51140717
150ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.50969010
151GATA1_19941826_ChIP-Seq_K562_Human0.50561434
152RXR_22108803_ChIP-Seq_LS180_Human0.50322682
153GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.49848452
154* STAT3_1855785_ChIP-Seq_MESCs_Mouse0.49828425
155TAF2_19829295_ChIP-Seq_ESCs_Human0.49439598
156CDX2_22108803_ChIP-Seq_LS180_Human0.48878175
157ESET_19884257_ChIP-Seq_ESCs_Mouse0.48068049
158MYC_19915707_ChIP-ChIP_AK7_Human0.46340882
159* RARA_24833708_ChIP-Seq_LIVER_Mouse0.45996120
160* KAP1_22055183_ChIP-Seq_ESCs_Mouse0.45794453
161SOX2_20726797_ChIP-Seq_SW620_Human0.45423671
162MYC_27129775_Chip-Seq_CORNEA_Mouse0.45367297
163RACK7_27058665_Chip-Seq_MCF-7_Human0.44065204
164SMAD4_21741376_ChIP-Seq_HESCs_Human0.43581844
165P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.43183844
166* PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.43161491
167TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.42937038
168GATA3_24758297_ChIP-Seq_MCF-7_Human0.42192564

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.27089695
2MP0005360_urolithiasis7.20624295
3MP0005365_abnormal_bile_salt5.42865214
4MP0005085_abnormal_gallbladder_physiolo5.28203202
5MP0008875_abnormal_xenobiotic_pharmacok4.40370590
6MP0004145_abnormal_muscle_electrophysio4.00588427
7MP0003806_abnormal_nucleotide_metabolis3.46447018
8MP0005332_abnormal_amino_acid3.40833829
9MP0003252_abnormal_bile_duct3.39456334
10MP0010329_abnormal_lipoprotein_level3.39292702
11MP0000749_muscle_degeneration2.99107466
12MP0003195_calcinosis2.75415411
13MP0004084_abnormal_cardiac_muscle2.74525044
14MP0009840_abnormal_foam_cell2.70454160
15MP0005670_abnormal_white_adipose2.53121531
16MP0004019_abnormal_vitamin_homeostasis2.46900521
17MP0003191_abnormal_cellular_cholesterol2.32051714
18MP0005083_abnormal_biliary_tract2.30753739
19MP0002118_abnormal_lipid_homeostasis2.23835442
20MP0001666_abnormal_nutrient_absorption2.19311574
21MP0000609_abnormal_liver_physiology2.00082544
22MP0004130_abnormal_muscle_cell1.97090242
23MP0004484_altered_response_of1.95434433
24MP0002106_abnormal_muscle_physiology1.89551614
25MP0005319_abnormal_enzyme/_coenzyme1.87302362
26MP0002132_abnormal_respiratory_system1.85595199
27MP0002138_abnormal_hepatobiliary_system1.85029045
28MP0009643_abnormal_urine_homeostasis1.83278351
29MP0005584_abnormal_enzyme/coenzyme_acti1.77247752
30MP0005666_abnormal_adipose_tissue1.72006716
31MP0003186_abnormal_redox_activity1.68410182
32MP0002837_dystrophic_cardiac_calcinosis1.68202134
33MP0002127_abnormal_cardiovascular_syste1.64482615
34MP0005369_muscle_phenotype1.59083705
35MP0001764_abnormal_homeostasis1.57325641
36MP0004043_abnormal_pH_regulation1.53082871
37MP0001835_abnormal_antigen_presentation1.51240294
38MP0000759_abnormal_skeletal_muscle1.47974479
39MP0002971_abnormal_brown_adipose1.42434293
40MP0000013_abnormal_adipose_tissue1.39257569
41MP0006036_abnormal_mitochondrial_physio1.33382481
42MP0003868_abnormal_feces_composition1.31447021
43MP0003705_abnormal_hypodermis_morpholog1.28115494
44MP0003646_muscle_fatigue1.26631731
45MP0003690_abnormal_glial_cell1.23020625
46MP0005464_abnormal_platelet_physiology1.22140384
47MP0005451_abnormal_body_composition1.21555885
48MP0005535_abnormal_body_temperature1.21293514
49MP0005636_abnormal_mineral_homeostasis1.21290731
50MP0005646_abnormal_pituitary_gland1.19633155
51MP0000747_muscle_weakness1.16480117
52MP0003828_pulmonary_edema1.15922913
53MP0001756_abnormal_urination1.14950279
54MP0002254_reproductive_system_inflammat1.14282416
55MP0002876_abnormal_thyroid_physiology1.09947514
56MP0003137_abnormal_impulse_conducting1.09816281
57MP0003011_delayed_dark_adaptation1.09479281
58MP0005647_abnormal_sex_gland1.08358375
59MP0000604_amyloidosis1.03828425
60MP0005334_abnormal_fat_pad1.03020331
61MP0004185_abnormal_adipocyte_glucose1.02717029
62MP0001661_extended_life_span1.01669160
63MP0002078_abnormal_glucose_homeostasis1.00083149
64MP0010630_abnormal_cardiac_muscle0.99068085
65MP0000598_abnormal_liver_morphology0.98311474
66MP0009764_decreased_sensitivity_to0.97931557
67MP0000372_irregular_coat_pigmentation0.97744971
68MP0001986_abnormal_taste_sensitivity0.93854020
69MP0005375_adipose_tissue_phenotype0.93748611
70MP0003879_abnormal_hair_cell0.93657231
71MP0004510_myositis0.92156592
72MP0000465_gastrointestinal_hemorrhage0.91925659
73MP0004147_increased_porphyrin_level0.91431053
74MP0003329_amyloid_beta_deposits0.91401237
75MP0003656_abnormal_erythrocyte_physiolo0.90451956
76MP0009697_abnormal_copulation0.90448951
77MP0002136_abnormal_kidney_physiology0.90164346
78MP0009642_abnormal_blood_homeostasis0.85869137
79MP0000750_abnormal_muscle_regeneration0.85298898
80MP0009115_abnormal_fat_cell0.84972901
81MP0004085_abnormal_heartbeat0.83231071
82MP0009763_increased_sensitivity_to0.82376810
83MP0005058_abnormal_lysosome_morphology0.81961267
84MP0001800_abnormal_humoral_immune0.81132596
85MP0005551_abnormal_eye_electrophysiolog0.80945904
86MP0001765_abnormal_ion_homeostasis0.80348400
87MP0005671_abnormal_response_to0.80008545
88MP0002108_abnormal_muscle_morphology0.78943353
89MP0001968_abnormal_touch/_nociception0.78818687
90MP0003045_fibrosis0.78385149
91MP0005000_abnormal_immune_tolerance0.78366266
92MP0003303_peritoneal_inflammation0.77428369
93MP0005376_homeostasis/metabolism_phenot0.76646869
94MP0008469_abnormal_protein_level0.74801756
95MP0009785_altered_susceptibility_to0.74487832
96MP0002148_abnormal_hypersensitivity_rea0.73899508
97MP0008872_abnormal_physiological_respon0.73269609
98MP0005084_abnormal_gallbladder_morpholo0.72165306
99MP0000230_abnormal_systemic_arterial0.71934923
100MP0005330_cardiomyopathy0.71284252
101MP0005266_abnormal_metabolism0.71036782
102MP0002638_abnormal_pupillary_reflex0.69841239
103MP0006035_abnormal_mitochondrial_morpho0.69653962
104MP0005448_abnormal_energy_balance0.68646268
105MP0001984_abnormal_olfaction0.68196236
106MP0000249_abnormal_blood_vessel0.67331676
107MP0005645_abnormal_hypothalamus_physiol0.67019627
108MP0005025_abnormal_response_to0.65933674
109MP0002723_abnormal_immune_serum0.64636806
110MP0002970_abnormal_white_adipose0.61859225
111MP0003075_altered_response_to0.59104412
112MP0009384_cardiac_valve_regurgitation0.57929302
113MP0002168_other_aberrant_phenotype0.57398845
114MP0003953_abnormal_hormone_level0.57041875
115MP0010368_abnormal_lymphatic_system0.56833095
116MP0001853_heart_inflammation0.55226307
117MP0005220_abnormal_exocrine_pancreas0.54493485
118MP0006138_congestive_heart_failure0.54110289
119MP0002269_muscular_atrophy0.52256684
120MP0003959_abnormal_lean_body0.51785268
121MP0002332_abnormal_exercise_endurance0.51593891
122MP0004215_abnormal_myocardial_fiber0.50022964
123MP0003724_increased_susceptibility_to0.49920419
124MP0009765_abnormal_xenobiotic_induced0.49124999
125MP0003638_abnormal_response/metabolism_0.49007397
126MP0004036_abnormal_muscle_relaxation0.48886880
127MP0001544_abnormal_cardiovascular_syste0.46852011
128MP0005385_cardiovascular_system_phenoty0.46852011
129MP0005620_abnormal_muscle_contractility0.46792151
130MP0005408_hypopigmentation0.46555458
131MP0008961_abnormal_basal_metabolism0.46027050
132MP0000751_myopathy0.44884495
133MP0008874_decreased_physiological_sensi0.44204491
134MP0005395_other_phenotype0.44163719
135MP0002972_abnormal_cardiac_muscle0.43418124
136MP0005165_increased_susceptibility_to0.43184214
137MP0004087_abnormal_muscle_fiber0.42091160
138MP0008775_abnormal_heart_ventricle0.41994928
139MP0002928_abnormal_bile_duct0.40812126
140MP0005167_abnormal_blood-brain_barrier0.40688261
141MP0005595_abnormal_vascular_smooth0.40662588
142MP0005452_abnormal_adipose_tissue0.40504154

Predicted human phenotypes

RankGene SetZ-score
1Muscle fiber inclusion bodies (HP:0100299)6.72979339
2Nemaline bodies (HP:0003798)6.61501153
3Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)6.46405697
4Abnormality of aromatic amino acid family metabolism (HP:0004338)5.77949299
5Hyperglycinuria (HP:0003108)5.71816537
6Exercise-induced myalgia (HP:0003738)5.65383247
7Intrahepatic cholestasis (HP:0001406)5.55737615
8Xanthomatosis (HP:0000991)5.42926485
9Deep venous thrombosis (HP:0002625)5.28531016
10Abnormality of glycine metabolism (HP:0010895)5.26145632
11Abnormality of serine family amino acid metabolism (HP:0010894)5.26145632
12Ketosis (HP:0001946)5.01362935
13Hyperammonemia (HP:0001987)4.90626874
14Hyperglycinemia (HP:0002154)4.90349063
15Type 1 muscle fiber predominance (HP:0003803)4.78974998
16Abnormality of monocarboxylic acid metabolism (HP:0010996)4.78938127
17Exercise-induced muscle cramps (HP:0003710)4.78544602
18Hyperlipoproteinemia (HP:0010980)4.69981480
19Muscle hypertrophy of the lower extremities (HP:0008968)4.63929078
20Abnormality of glutamine family amino acid metabolism (HP:0010902)4.56365546
21Ketoacidosis (HP:0001993)4.44368488
22Prolonged partial thromboplastin time (HP:0003645)4.41272458
23Hypoglycemic coma (HP:0001325)4.34886160
24Abnormality of fatty-acid metabolism (HP:0004359)4.31162175
25Complement deficiency (HP:0004431)4.27104376
26Hypobetalipoproteinemia (HP:0003563)4.23068309
27Sudden death (HP:0001699)4.04651384
28Calf muscle hypertrophy (HP:0008981)4.03730674
29Hypoalphalipoproteinemia (HP:0003233)3.96043088
30Abnormality of aspartate family amino acid metabolism (HP:0010899)3.92203681
31EMG: myopathic abnormalities (HP:0003458)3.88091140
32Hypolipoproteinemia (HP:0010981)3.83905370
33Hyporeflexia of lower limbs (HP:0002600)3.81754337
34Gout (HP:0001997)3.80661335
35Abnormality of sulfur amino acid metabolism (HP:0004339)3.78166876
36Epidermoid cyst (HP:0200040)3.77300942
37Muscle fiber splitting (HP:0003555)3.70842717
38Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.58708832
39Dicarboxylic aciduria (HP:0003215)3.54621346
40Abnormality of dicarboxylic acid metabolism (HP:0010995)3.54621346
41Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.53525138
42Asymmetric septal hypertrophy (HP:0001670)3.52385847
43Distal arthrogryposis (HP:0005684)3.49509728
44Abnormality of purine metabolism (HP:0004352)3.46357542
45Bundle branch block (HP:0011710)3.43555658
46Abnormality of the calf musculature (HP:0001430)3.41698986
47Joint hemorrhage (HP:0005261)3.40186958
48Neck muscle weakness (HP:0000467)3.33241906
49Abnormality of serum amino acid levels (HP:0003112)3.28562643
50Abnormality of methionine metabolism (HP:0010901)3.27575047
51Abnormality of the left ventricular outflow tract (HP:0011103)3.27147121
52Subaortic stenosis (HP:0001682)3.27147121
53Delayed CNS myelination (HP:0002188)3.25529632
54Generalized aminoaciduria (HP:0002909)3.23762908
55Metabolic acidosis (HP:0001942)3.17038295
56Abnormality of nucleobase metabolism (HP:0010932)3.16321773
57Rimmed vacuoles (HP:0003805)3.14032506
58Proximal tubulopathy (HP:0000114)3.12212380
59Fat malabsorption (HP:0002630)3.07813945
60Abnormality of the common coagulation pathway (HP:0010990)3.05825703
61Lethargy (HP:0001254)3.03656327
62Abnormality of complement system (HP:0005339)2.94709538
63Hyperuricemia (HP:0002149)2.94444556
64Increased purine levels (HP:0004368)2.94444556
65Heart block (HP:0012722)2.93298028
66Hypercholesterolemia (HP:0003124)2.92931336
67Myotonia (HP:0002486)2.92239654
68Ventricular tachycardia (HP:0004756)2.86754878
69Hydroxyprolinuria (HP:0003080)2.85640489
70Abnormality of proline metabolism (HP:0010907)2.85640489
71Myopathic facies (HP:0002058)2.81365955
72Centrally nucleated skeletal muscle fibers (HP:0003687)2.79153871
73Cerebral edema (HP:0002181)2.77299708
74Abnormality of skeletal muscle fiber size (HP:0012084)2.66707320
75Hyperbilirubinemia (HP:0002904)2.64878231
76Vomiting (HP:0002013)2.64542995
77Myoglobinuria (HP:0002913)2.64258848
78Round ear (HP:0100830)2.62492845
79Abnormality of the intrinsic pathway (HP:0010989)2.60935265
80Abnormal atrioventricular conduction (HP:0005150)2.60632808
81Muscle stiffness (HP:0003552)2.59237412
82Myocardial infarction (HP:0001658)2.57573565
83Abnormality of pyrimidine metabolism (HP:0004353)2.56250235
84Vascular calcification (HP:0004934)2.56186670
85Areflexia of lower limbs (HP:0002522)2.55140815
86Atrioventricular block (HP:0001678)2.55055749
87Conjugated hyperbilirubinemia (HP:0002908)2.54463411
88Frequent falls (HP:0002359)2.51570399
89Skin nodule (HP:0200036)2.49874429
90Alkalosis (HP:0001948)2.48952217
91Difficulty running (HP:0009046)2.47734972
92Sensorimotor neuropathy (HP:0007141)2.46157891
93Facial diplegia (HP:0001349)2.43964980
94Hepatocellular carcinoma (HP:0001402)2.42904834
95Ulnar deviation of the wrist (HP:0003049)2.39175770
96Late onset (HP:0003584)2.38336314
97Dilated cardiomyopathy (HP:0001644)2.37004564
98Hypoglycemic seizures (HP:0002173)2.35364132
99Distal lower limb muscle weakness (HP:0009053)2.33864657
100Syncope (HP:0001279)2.32712760
101Enlarged kidneys (HP:0000105)2.32112400
102Steatorrhea (HP:0002570)2.31473241
103Glycosuria (HP:0003076)2.31269940
104Abnormality of urine glucose concentration (HP:0011016)2.31269940
105Pancreatitis (HP:0001733)2.31028744
106Gingival bleeding (HP:0000225)2.29360404
107Cardiovascular calcification (HP:0011915)2.29030469
108Systemic lupus erythematosus (HP:0002725)2.27177472
109Generalized muscle weakness (HP:0003324)2.26544893
110Nausea (HP:0002018)2.26471749
111EMG: neuropathic changes (HP:0003445)2.25776795
112Irritability (HP:0000737)2.24370828
113Ventricular arrhythmia (HP:0004308)2.23633833
114Neonatal onset (HP:0003623)2.22599841
115Atrial fibrillation (HP:0005110)2.20052362
116Lipoatrophy (HP:0100578)2.18896773
117Decreased central vision (HP:0007663)2.17842066
118Increased variability in muscle fiber diameter (HP:0003557)2.16748011
119Spastic diplegia (HP:0001264)2.15818219
120Hypertriglyceridemia (HP:0002155)2.15814257
121Renal cortical cysts (HP:0000803)2.13618790
122Methylmalonic aciduria (HP:0012120)2.11076412
123Hyperinsulinemic hypoglycemia (HP:0000825)2.09374343
124Hypokalemic alkalosis (HP:0001949)2.08712185
125Absent phalangeal crease (HP:0006109)2.08525272
126Malnutrition (HP:0004395)2.08190182
127Primary atrial arrhythmia (HP:0001692)2.06876272
128Gowers sign (HP:0003391)2.05053715
129Increased intramyocellular lipid droplets (HP:0012240)2.04275679
130Cholelithiasis (HP:0001081)2.03864685
131Abnormal gallbladder morphology (HP:0012437)2.03243925
132Rhabdomyolysis (HP:0003201)1.99362119
133Chest pain (HP:0100749)1.95866130
134Increased circulating renin level (HP:0000848)1.92598034
135Hepatic necrosis (HP:0002605)1.91602662
136Supraventricular tachycardia (HP:0004755)1.91278290
137Epistaxis (HP:0000421)1.89277870
138Abnormal cartilage morphology (HP:0002763)1.89018980
139Prolonged bleeding time (HP:0003010)1.88521381
140Ragged-red muscle fibers (HP:0003200)1.88461878
141Brushfield spots (HP:0001088)1.88351083
142Amyloidosis (HP:0011034)1.87400730
143Recurrent gram-negative bacterial infections (HP:0005420)1.87159522
144Esophageal varix (HP:0002040)1.86734324
145Rickets (HP:0002748)1.86488260
146Hemorrhage of the eye (HP:0011885)1.84889352
147Supraventricular arrhythmia (HP:0005115)1.83978732
148Acute encephalopathy (HP:0006846)1.83763756
149Mitral stenosis (HP:0001718)1.83495960
150Increased muscle lipid content (HP:0009058)1.82510846
151Spontaneous abortion (HP:0005268)1.81800418
152Oligomenorrhea (HP:0000876)1.81201842
153Metabolic alkalosis (HP:0200114)1.80988930
154Abnormal urine output (HP:0012590)1.79794494
155Back pain (HP:0003418)1.79690653
156Cerebral palsy (HP:0100021)1.79189434
157Increased connective tissue (HP:0009025)1.76591953
158Abnormal enzyme/coenzyme activity (HP:0012379)1.75892217
159Abnormal finger flexion creases (HP:0006143)1.75489394
160Elevated hepatic transaminases (HP:0002910)1.75288123
161Nephrolithiasis (HP:0000787)1.74715850
162Elevated erythrocyte sedimentation rate (HP:0003565)1.70809354
163Weak cry (HP:0001612)1.68968368
164Malignant hyperthermia (HP:0002047)1.66581884
165Palpitations (HP:0001962)1.65927231
166Decreased electroretinogram (ERG) amplitude (HP:0000654)1.65679900
167Abnormality of the prostate (HP:0008775)1.64226263

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.91120241
2SIK14.05879983
3TRIB33.52499993
4ERN13.10472628
5FGFR42.83399301
6PDK32.67598595
7PDK42.67598595
8WNK42.58569668
9INSRR2.42114259
10LMTK22.19973276
11WNK32.16337794
12TXK2.11956330
13PKN21.95053238
14MST1R1.89604722
15PINK11.88330204
16FES1.87636193
17CAMK1D1.84601027
18OXSR11.78474534
19MAP4K21.78290594
20KIT1.77540480
21PDK21.75559427
22MAPKAPK31.72170097
23PHKG21.68797492
24PHKG11.68797492
25ITK1.55485514
26ERBB41.52854444
27PRKAA21.52735723
28TEC1.43125364
29MAP2K41.42389093
30STK38L1.37336854
31MAPK111.35315075
32MAP4K11.33145038
33SYK1.26813416
34CAMK1G1.26690864
35TRPM71.26228553
36MUSK1.25110664
37LATS11.24386786
38NEK91.24251246
39IKBKE1.23485082
40MAP3K71.17074356
41TAOK31.15636452
42TNK21.15202196
43SGK31.10938099
44TIE11.09859566
45SGK4941.09721839
46SGK2231.09721839
47BTK1.09376939
48CSF1R1.08384815
49BLK1.05765053
50PRKAA11.03677208
51SGK21.00828632
52NEK11.00615032
53ZAP701.00102845
54MAPK120.99470435
55ADRBK20.99288354
56PTK60.99139087
57FGFR20.98545062
58FRK0.96897893
59FLT30.96826950
60TTN0.96444019
61PIK3CG0.95439019
62ABL20.91661421
63PRKG20.91308339
64IRAK30.91290785
65STK390.87540359
66TYK20.86338246
67RIPK10.85708108
68JAK20.85492511
69RIPK40.83713547
70DYRK1B0.81510183
71EPHB10.80984424
72EPHA40.80913797
73TGFBR20.79564653
74MAP3K140.79523268
75JAK10.78285342
76OBSCN0.77670939
77DAPK20.77199769
78PDPK10.77051017
79ERBB30.76024031
80CAMK10.75977658
81MAPK130.75500209
82PRKACG0.75076390
83GRK10.74683808
84MET0.74647465
85LCK0.74373005
86NTRK30.73380036
87IKBKB0.72734773
88PRKG10.72611578
89LYN0.72195191
90TNIK0.71643049
91MYLK0.69335883
92PIK3CA0.69223885
93GSK3A0.69210750
94NLK0.68312142
95HCK0.68127998
96CAMK2D0.68025329
97FGFR30.63003480
98STK380.60638605
99PRKCZ0.60609115
100IRAK10.60554692
101NUAK10.60481283
102MAP2K30.59621013
103GRK60.59569216
104MAPK150.59076923
105MAPK40.58714224
106PDK10.55969949
107CAMK2A0.54859633
108ROCK10.52964149
109MAP3K130.51164958
110KDR0.50465434
111MAP2K10.50030479
112PAK30.49035202
113TLK10.47940612
114IRAK20.47245633
115MAP2K20.47091806
116CAMK2G0.44143633
117EIF2AK30.43854851
118BMPR1B0.43636696
119IGF1R0.43228867
120MAP3K10.42801509
121GRK70.42657753
122JAK30.42368718
123MAP3K60.42358320
124MAP3K30.41951045
125PRKD10.41371704
126TAOK20.41052392
127PRKD20.41004254
128CDK60.41000151
129TBK10.40502321
130PRKCE0.39843710
131DMPK0.39539265
132ERBB20.38419754
133MAPK70.38267220
134BMX0.37981691
135ADRBK10.36960628
136PRKCQ0.36368241
137PDGFRA0.35789677
138RET0.34697731
139MAP2K60.33428328
140CSK0.31099222
141PRKCH0.30997322
142LRRK20.30251854
143PTK20.29737317
144MAP3K50.29359299
145PRKACA0.27691104
146MTOR0.27505986
147PKN10.26378687
148EPHA30.26117376
149SGK10.25854653
150CAMK40.25732273

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.65280914
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.53200473
3Valine, leucine and isoleucine degradation_Homo sapiens_hsa002803.08120384
4Fatty acid degradation_Homo sapiens_hsa000713.02122004
5Propanoate metabolism_Homo sapiens_hsa006402.97447530
6Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.90760123
7Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.89392265
8Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.88344945
9Arginine biosynthesis_Homo sapiens_hsa002202.63130252
10Butanoate metabolism_Homo sapiens_hsa006502.60198521
11Tryptophan metabolism_Homo sapiens_hsa003802.55840827
12Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.53884203
13Fatty acid metabolism_Homo sapiens_hsa012122.42723220
14Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.32821622
152-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.32202901
16Peroxisome_Homo sapiens_hsa041462.26589895
17PPAR signaling pathway_Homo sapiens_hsa033202.26261579
18Pentose and glucuronate interconversions_Homo sapiens_hsa000402.11067569
19Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.06470735
20Complement and coagulation cascades_Homo sapiens_hsa046101.97090729
21beta-Alanine metabolism_Homo sapiens_hsa004101.89232058
22Pyruvate metabolism_Homo sapiens_hsa006201.86425484
23Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.79328420
24Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.74068962
25Carbon metabolism_Homo sapiens_hsa012001.59738039
26Asthma_Homo sapiens_hsa053101.57885462
27Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.56194900
28Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.54164602
29Allograft rejection_Homo sapiens_hsa053301.51936717
30Chemical carcinogenesis_Homo sapiens_hsa052041.51880774
31Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.50128014
32Graft-versus-host disease_Homo sapiens_hsa053321.50014230
33Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.49134152
34Histidine metabolism_Homo sapiens_hsa003401.48114621
35Autoimmune thyroid disease_Homo sapiens_hsa053201.45254748
36Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.44557503
37Caffeine metabolism_Homo sapiens_hsa002321.43874443
38Dilated cardiomyopathy_Homo sapiens_hsa054141.41680027
39Fatty acid elongation_Homo sapiens_hsa000621.41653950
40Bile secretion_Homo sapiens_hsa049761.41473621
41Steroid hormone biosynthesis_Homo sapiens_hsa001401.40649500
42Phenylalanine metabolism_Homo sapiens_hsa003601.38897952
43Sulfur metabolism_Homo sapiens_hsa009201.38091249
44Starch and sucrose metabolism_Homo sapiens_hsa005001.29417980
45Biosynthesis of amino acids_Homo sapiens_hsa012301.28034872
46Retinol metabolism_Homo sapiens_hsa008301.26504161
47Fatty acid biosynthesis_Homo sapiens_hsa000611.25747399
48Intestinal immune network for IgA production_Homo sapiens_hsa046721.24205459
49Selenocompound metabolism_Homo sapiens_hsa004501.23422164
50Drug metabolism - other enzymes_Homo sapiens_hsa009831.22898712
51Staphylococcus aureus infection_Homo sapiens_hsa051501.21877950
52Tyrosine metabolism_Homo sapiens_hsa003501.21615332
53Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.12799224
54Type I diabetes mellitus_Homo sapiens_hsa049401.12646386
55Cysteine and methionine metabolism_Homo sapiens_hsa002701.11153688
56Cyanoamino acid metabolism_Homo sapiens_hsa004601.09026577
57Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.08697554
58Glycerolipid metabolism_Homo sapiens_hsa005611.04569618
59Arginine and proline metabolism_Homo sapiens_hsa003301.00831251
60Fat digestion and absorption_Homo sapiens_hsa049751.00354602
61ABC transporters_Homo sapiens_hsa020100.93338711
62Lysine degradation_Homo sapiens_hsa003100.92267761
63Folate biosynthesis_Homo sapiens_hsa007900.90835030
64Vitamin digestion and absorption_Homo sapiens_hsa049770.90577995
65Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.90565414
66Steroid biosynthesis_Homo sapiens_hsa001000.83570377
67Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.83534315
68Viral myocarditis_Homo sapiens_hsa054160.81799198
69Vitamin B6 metabolism_Homo sapiens_hsa007500.79037128
70Sulfur relay system_Homo sapiens_hsa041220.78676518
71Renin secretion_Homo sapiens_hsa049240.77117792
72Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.76743561
73Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.74830008
74Glutathione metabolism_Homo sapiens_hsa004800.72965192
75Phototransduction_Homo sapiens_hsa047440.69529175
76Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.67304400
77Platelet activation_Homo sapiens_hsa046110.64643960
78Pentose phosphate pathway_Homo sapiens_hsa000300.64212002
79Vascular smooth muscle contraction_Homo sapiens_hsa042700.64127975
80Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.62598449
81Oxytocin signaling pathway_Homo sapiens_hsa049210.60796759
82Leishmaniasis_Homo sapiens_hsa051400.59621292
83Primary immunodeficiency_Homo sapiens_hsa053400.54634901
84Maturity onset diabetes of the young_Homo sapiens_hsa049500.54472340
85Adipocytokine signaling pathway_Homo sapiens_hsa049200.53779968
86Salivary secretion_Homo sapiens_hsa049700.52645546
87Metabolic pathways_Homo sapiens_hsa011000.49784141
88Calcium signaling pathway_Homo sapiens_hsa040200.49711102
89Fructose and mannose metabolism_Homo sapiens_hsa000510.48155177
90Circadian entrainment_Homo sapiens_hsa047130.44002850
91Insulin resistance_Homo sapiens_hsa049310.41651677
92cGMP-PKG signaling pathway_Homo sapiens_hsa040220.41204875
93Rheumatoid arthritis_Homo sapiens_hsa053230.40600219
94Pertussis_Homo sapiens_hsa051330.39249807
95Gastric acid secretion_Homo sapiens_hsa049710.38265292
96Antigen processing and presentation_Homo sapiens_hsa046120.34580151
97Pancreatic secretion_Homo sapiens_hsa049720.34402473
98Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.34092463
99Regulation of autophagy_Homo sapiens_hsa041400.29587941
100Glucagon signaling pathway_Homo sapiens_hsa049220.28599183
101Olfactory transduction_Homo sapiens_hsa047400.28476010
102Hematopoietic cell lineage_Homo sapiens_hsa046400.28245015
103Serotonergic synapse_Homo sapiens_hsa047260.27899014
104Galactose metabolism_Homo sapiens_hsa000520.27620291
105Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.27526671
106AMPK signaling pathway_Homo sapiens_hsa041520.27388424
107alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.26556881
108One carbon pool by folate_Homo sapiens_hsa006700.26339004
109Glycerophospholipid metabolism_Homo sapiens_hsa005640.22047481
110Prion diseases_Homo sapiens_hsa050200.13684538
111Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.10808747
112Insulin signaling pathway_Homo sapiens_hsa049100.08841654
113Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.08425766
114Linoleic acid metabolism_Homo sapiens_hsa005910.08289223
115Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.08260836
116Oxidative phosphorylation_Homo sapiens_hsa001900.05519072
117Protein digestion and absorption_Homo sapiens_hsa049740.01392307
118Glycosaminoglycan degradation_Homo sapiens_hsa005310.01096670
119Other glycan degradation_Homo sapiens_hsa00511-0.1249275
120Cardiac muscle contraction_Homo sapiens_hsa04260-0.1226100
121Circadian rhythm_Homo sapiens_hsa04710-0.1102120
122Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960-0.0988066
123Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0967919
124Lysosome_Homo sapiens_hsa04142-0.0951230
125Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.0862175
126Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.0843846
127Renin-angiotensin system_Homo sapiens_hsa04614-0.0823427
128Thyroid hormone synthesis_Homo sapiens_hsa04918-0.0802960
129Alzheimers disease_Homo sapiens_hsa05010-0.0742186
130Arachidonic acid metabolism_Homo sapiens_hsa00590-0.0732252
131Mineral absorption_Homo sapiens_hsa04978-0.0661551
132Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.0459545
133Parkinsons disease_Homo sapiens_hsa05012-0.0225457

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