ADH6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes class V alcohol dehydrogenase, which is a member of the alcohol dehydrogenase family. Members of this family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. This gene is expressed in the stomach as well as in the liver, and it contains a glucocorticoid response element upstream of its 5' UTR, which is a steroid hormone receptor binding site. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of fibrinolysis (GO:0051917)8.55031293
2exogenous drug catabolic process (GO:0042738)8.53971840
3negative regulation of fibrinolysis (GO:0051918)8.40605163
4epoxygenase P450 pathway (GO:0019373)8.32436506
5drug catabolic process (GO:0042737)7.96649047
6omega-hydroxylase P450 pathway (GO:0097267)7.76641907
7L-phenylalanine catabolic process (GO:0006559)7.68658872
8erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.68658872
9regulation of protein activation cascade (GO:2000257)7.56424882
10complement activation, alternative pathway (GO:0006957)7.49519949
11regulation of complement activation (GO:0030449)7.23063031
12glyoxylate metabolic process (GO:0046487)7.11205592
13L-phenylalanine metabolic process (GO:0006558)7.07524683
14erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.07524683
15peptidyl-glutamic acid carboxylation (GO:0017187)6.78360235
16protein carboxylation (GO:0018214)6.78360235
17* ethanol oxidation (GO:0006069)6.60418723
18blood coagulation, intrinsic pathway (GO:0007597)6.20481702
19fibrinolysis (GO:0042730)6.19859531
20urea metabolic process (GO:0019627)5.83345985
21drug metabolic process (GO:0017144)5.77184546
22cellular glucuronidation (GO:0052695)5.71661870
23aromatic amino acid family catabolic process (GO:0009074)5.67958843
24negative regulation of sterol transport (GO:0032372)5.61018964
25negative regulation of cholesterol transport (GO:0032375)5.61018964
26uronic acid metabolic process (GO:0006063)5.44605984
27glucuronate metabolic process (GO:0019585)5.44605984
28triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.41272516
29* ethanol metabolic process (GO:0006067)5.37191145
30regulation of plasminogen activation (GO:0010755)5.34058525
31nitrogen cycle metabolic process (GO:0071941)5.30165033
32serine family amino acid catabolic process (GO:0009071)5.26544432
33bile acid biosynthetic process (GO:0006699)5.22284942
34oxidative demethylation (GO:0070989)5.15172625
35imidazole-containing compound metabolic process (GO:0052803)5.07554990
36protein activation cascade (GO:0072376)5.01798962
37bile acid metabolic process (GO:0008206)4.99787676
38urea cycle (GO:0000050)4.97467737
39regulation of triglyceride catabolic process (GO:0010896)4.94109977
40negative regulation of blood coagulation (GO:0030195)4.85965447
41negative regulation of hemostasis (GO:1900047)4.85965447
42protein-lipid complex remodeling (GO:0034368)4.80518706
43macromolecular complex remodeling (GO:0034367)4.80518706
44plasma lipoprotein particle remodeling (GO:0034369)4.80518706
45intestinal cholesterol absorption (GO:0030299)4.78812620
46cholesterol efflux (GO:0033344)4.74664537
47glycine metabolic process (GO:0006544)4.68331931
48phenylpropanoid metabolic process (GO:0009698)4.67076419
49high-density lipoprotein particle remodeling (GO:0034375)4.65119451
50complement activation, classical pathway (GO:0006958)4.64188779
51very-low-density lipoprotein particle assembly (GO:0034379)4.63975766
52bile acid and bile salt transport (GO:0015721)4.61729502
53triglyceride homeostasis (GO:0070328)4.55066595
54acylglycerol homeostasis (GO:0055090)4.55066595
55complement activation (GO:0006956)4.54930798
56regulation of humoral immune response (GO:0002920)4.50973214
57negative regulation of protein activation cascade (GO:2000258)4.48363321
58negative regulation of coagulation (GO:0050819)4.43094331
59acute-phase response (GO:0006953)4.42751360
60glutamate metabolic process (GO:0006536)4.34123942
61negative regulation of wound healing (GO:0061045)4.31611234
62tyrosine metabolic process (GO:0006570)4.29866531
63regulation of cholesterol esterification (GO:0010872)4.29814083
64phospholipid efflux (GO:0033700)4.26738406
65positive regulation of blood coagulation (GO:0030194)4.26087259
66positive regulation of hemostasis (GO:1900048)4.26087259
67reverse cholesterol transport (GO:0043691)4.22545663
68positive regulation of lipoprotein lipase activity (GO:0051006)4.18898770
69positive regulation of triglyceride lipase activity (GO:0061365)4.18898770
70amino-acid betaine metabolic process (GO:0006577)4.07841034
71S-adenosylmethionine metabolic process (GO:0046500)4.07677743
72opsonization (GO:0008228)4.03320597
73cytolysis (GO:0019835)4.02235740
74plasma lipoprotein particle assembly (GO:0034377)3.98637073
75killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.95418047
76disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.95418047
77negative regulation of lipase activity (GO:0060192)3.95255542
78fat-soluble vitamin biosynthetic process (GO:0042362)3.91234682
79positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.91037351
80regulation of apoptotic cell clearance (GO:2000425)3.89871171
81positive regulation of coagulation (GO:0050820)3.89832140
82indolalkylamine catabolic process (GO:0046218)3.89558818
83tryptophan catabolic process (GO:0006569)3.89558818
84indole-containing compound catabolic process (GO:0042436)3.89558818
85flavonoid metabolic process (GO:0009812)3.86479267
86alpha-amino acid catabolic process (GO:1901606)3.85958692
87plasma lipoprotein particle organization (GO:0071827)3.83538053
88serine family amino acid metabolic process (GO:0009069)3.79093038
89alkaloid metabolic process (GO:0009820)3.75103308
90plasma lipoprotein particle clearance (GO:0034381)3.73550505
91arginine metabolic process (GO:0006525)3.73401320
92low-density lipoprotein particle remodeling (GO:0034374)3.71374992
93aromatic amino acid family metabolic process (GO:0009072)3.69609204
94negative regulation of complement activation (GO:0045916)3.68677044
95protein-lipid complex subunit organization (GO:0071825)3.58981847
96protein-lipid complex assembly (GO:0065005)3.51939693
97response to mercury ion (GO:0046689)3.50435673
98hormone catabolic process (GO:0042447)3.48124061
99fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.47124013
100regulation of bile acid biosynthetic process (GO:0070857)3.44611846

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse6.78408713
2EGR1_23403033_ChIP-Seq_LIVER_Mouse6.39580783
3PPARA_22158963_ChIP-Seq_LIVER_Mouse5.68939595
4LXR_22158963_ChIP-Seq_LIVER_Mouse5.66452567
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.76443433
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.49584674
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.00527425
8CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.83657054
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.78876122
10FOXA2_19822575_ChIP-Seq_HepG2_Human2.87064531
11* HNF4A_19822575_ChIP-Seq_HepG2_Human2.57525418
12* HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.47299289
13TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.02172282
14ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.1523317
15E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.66912500
16CDX2_20551321_ChIP-Seq_CACO-2_Human1.52504898
17ESR1_15608294_ChIP-ChIP_MCF-7_Human1.52287539
18TRIM28_21343339_ChIP-Seq_HEK293_Human1.47878635
19HTT_18923047_ChIP-ChIP_STHdh_Human1.43225633
20GATA4_25053715_ChIP-Seq_YYC3_Human1.37881919
21THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.31328398
22* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.24401165
23AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.23927813
24CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.22558474
25ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.22403565
26FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.14736233
27ESR1_20079471_ChIP-ChIP_T-47D_Human1.12701379
28TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.12225108
29FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.06730040
30IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.06570187
31GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.02793703
32SOX2_27498859_Chip-Seq_STOMACH_Mouse1.02320995
33MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.02126723
34KAP1_22055183_ChIP-Seq_ESCs_Mouse0.98785583
35FOXA1_25552417_ChIP-Seq_VCAP_Human0.96949070
36TCF4_18268006_ChIP-ChIP_LS174T_Human0.96758598
37RXRA_24833708_ChIP-Seq_LIVER_Mouse0.96384079
38NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.95061235
39STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.94431126
40PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.93531101
41GATA6_25053715_ChIP-Seq_YYC3_Human0.89445603
42FOXO3_23340844_ChIP-Seq_DLD1_Human0.88929928
43BCAT_22108803_ChIP-Seq_LS180_Human0.88838686
44SALL4_18804426_ChIP-ChIP_XEN_Mouse0.86640029
45CEBPB_22108803_ChIP-Seq_LS180_Human0.85361379
46PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.82435532
47TP53_18474530_ChIP-ChIP_U2OS_Human0.81664225
48SOX2_21211035_ChIP-Seq_LN229_Human0.79528783
49SOX2_20726797_ChIP-Seq_SW620_Human0.77849808
50NFE2_27457419_Chip-Seq_LIVER_Mouse0.77508870
51PIAS1_25552417_ChIP-Seq_VCAP_Human0.76510178
52* AR_20517297_ChIP-Seq_VCAP_Human0.76235353
53STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.75833911
54HNFA_21074721_ChIP-Seq_CACO-2_Human0.71935812
55CLOCK_20551151_ChIP-Seq_293T_Human0.71164154
56CDX2_22108803_ChIP-Seq_LS180_Human0.71079084
57ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.70750434
58CDX2_19796622_ChIP-Seq_MESCs_Mouse0.70716979
59TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.69706320
60CBP_21632823_ChIP-Seq_H3396_Human0.69419126
61PCGF2_27294783_Chip-Seq_NPCs_Mouse0.68779613
62IRF1_19129219_ChIP-ChIP_H3396_Human0.68771084
63RAD21_21589869_ChIP-Seq_MESCs_Mouse0.68753927
64CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.68371537
65RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.67715347
66RAC3_21632823_ChIP-Seq_H3396_Human0.67403778
67CBX2_22325352_ChIP-Seq_293T-Rex_Human0.65666333
68MYC_19829295_ChIP-Seq_ESCs_Human0.65186269
69EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.63255986
70SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.63142351
71ETV1_20927104_ChIP-Seq_GIST48_Human0.62085265
72CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.61838789
73ESR2_21235772_ChIP-Seq_MCF-7_Human0.61493874
74PHF8_20622853_ChIP-Seq_HELA_Human0.61221832
75EZH2_27294783_Chip-Seq_NPCs_Mouse0.60997323
76ESRRB_18555785_Chip-Seq_ESCs_Mouse0.60661104
77SMAD1_18555785_Chip-Seq_ESCs_Mouse0.59602463
78OCT4_18555785_Chip-Seq_ESCs_Mouse0.59178826
79ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.59127075
80PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.59090088
81SUZ12_27294783_Chip-Seq_NPCs_Mouse0.58256406
82STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.56544865
83ETV2_25802403_ChIP-Seq_MESCs_Mouse0.55972864
84SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.55173095
85RUNX1_27457419_Chip-Seq_LIVER_Mouse0.55140427
86NFYA_21822215_ChIP-Seq_K562_Human0.54926552
87KLF5_20875108_ChIP-Seq_MESCs_Mouse0.53703056
88FOXH1_21741376_ChIP-Seq_EPCs_Human0.53576907
89SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.53081430
90P53_21459846_ChIP-Seq_SAOS-2_Human0.52859760
91CRX_20693478_ChIP-Seq_RETINA_Mouse0.52009079
92POU5F1_16518401_ChIP-PET_MESCs_Mouse0.51144939
93PU1_27457419_Chip-Seq_LIVER_Mouse0.50916412
94LXR_22292898_ChIP-Seq_THP-1_Human0.50510952
95BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.49887429
96PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.49676596
97ZFX_18555785_Chip-Seq_ESCs_Mouse0.49595754
98TCF4_22108803_ChIP-Seq_LS180_Human0.49576337
99TAF2_19829295_ChIP-Seq_ESCs_Human0.49487963
100GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.49010848

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system9.54442819
2MP0005360_urolithiasis6.70375619
3MP0005085_abnormal_gallbladder_physiolo6.08414009
4MP0008875_abnormal_xenobiotic_pharmacok5.88823775
5MP0005365_abnormal_bile_salt5.77511273
6MP0003195_calcinosis5.07676746
7MP0003252_abnormal_bile_duct3.89054544
8MP0001666_abnormal_nutrient_absorption3.85195377
9MP0010329_abnormal_lipoprotein_level3.34985836
10MP0002138_abnormal_hepatobiliary_system3.23793218
11MP0003868_abnormal_feces_composition3.01420035
12MP0005332_abnormal_amino_acid2.42495614
13MP0009697_abnormal_copulation2.27532882
14MP0003806_abnormal_nucleotide_metabolis2.03481415
15MP0002876_abnormal_thyroid_physiology1.87683630
16MP0000609_abnormal_liver_physiology1.87075683
17MP0009840_abnormal_foam_cell1.86565583
18MP0010368_abnormal_lymphatic_system1.84997003
19MP0002118_abnormal_lipid_homeostasis1.78707904
20MP0003191_abnormal_cellular_cholesterol1.75116537
21MP0004019_abnormal_vitamin_homeostasis1.64439665
22MP0001764_abnormal_homeostasis1.53855643
23MP0002132_abnormal_respiratory_system1.51873295
24MP0005408_hypopigmentation1.47383083
25MP0005670_abnormal_white_adipose1.22793195
26MP0003656_abnormal_erythrocyte_physiolo1.16353685
27MP0001661_extended_life_span1.14131547
28MP0005319_abnormal_enzyme/_coenzyme1.12584540
29MP0009643_abnormal_urine_homeostasis1.08837248
30MP0000598_abnormal_liver_morphology1.02370442
31MP0005636_abnormal_mineral_homeostasis0.99875592
32MP0009053_abnormal_anal_canal0.96572898
33MP0003879_abnormal_hair_cell0.95856105
34MP0005584_abnormal_enzyme/coenzyme_acti0.94185764
35MP0009642_abnormal_blood_homeostasis0.92343103
36MP0000566_synostosis0.91330285
37MP0003122_maternal_imprinting0.89012021
38MP0005451_abnormal_body_composition0.88334836
39MP0001915_intracranial_hemorrhage0.87994567
40MP0002282_abnormal_trachea_morphology0.87196128
41MP0002971_abnormal_brown_adipose0.80276308
42MP0008872_abnormal_physiological_respon0.79480830
43MP0009763_increased_sensitivity_to0.77911087
44MP0002249_abnormal_larynx_morphology0.75393227
45MP0005376_homeostasis/metabolism_phenot0.74447233
46MP0008469_abnormal_protein_level0.72455022
47MP0000604_amyloidosis0.68478914
48MP0003011_delayed_dark_adaptation0.67856100
49MP0005464_abnormal_platelet_physiology0.67215934
50MP0002078_abnormal_glucose_homeostasis0.64926430
51MP0005395_other_phenotype0.64135446
52MP0002089_abnormal_postnatal_growth/wei0.61798153
53MP0009764_decreased_sensitivity_to0.60605477
54MP0003638_abnormal_response/metabolism_0.59691917
55MP0005377_hearing/vestibular/ear_phenot0.58243726
56MP0003878_abnormal_ear_physiology0.58243726
57MP0003186_abnormal_redox_activity0.55245580
58MP0005535_abnormal_body_temperature0.53612992
59MP0005334_abnormal_fat_pad0.51079004
60MP0005448_abnormal_energy_balance0.50793400
61MP0002168_other_aberrant_phenotype0.49696338
62MP0005084_abnormal_gallbladder_morpholo0.49326222
63MP0009780_abnormal_chondrocyte_physiolo0.49072446
64MP0004043_abnormal_pH_regulation0.48781772
65MP0000639_abnormal_adrenal_gland0.46087665
66MP0005409_darkened_coat_color0.44432782
67MP0004782_abnormal_surfactant_physiolog0.44432593
68MP0001756_abnormal_urination0.43737923
69MP0003953_abnormal_hormone_level0.42744293
70MP0003718_maternal_effect0.42659634
71MP0005266_abnormal_metabolism0.42497565
72MP0004130_abnormal_muscle_cell0.41266761
73MP0005187_abnormal_penis_morphology0.40750061
74MP0002136_abnormal_kidney_physiology0.40337562
75MP0005058_abnormal_lysosome_morphology0.39237871
76MP0005023_abnormal_wound_healing0.39199933
77MP0009765_abnormal_xenobiotic_induced0.38282854
78MP0005220_abnormal_exocrine_pancreas0.37691771
79MP0009115_abnormal_fat_cell0.36590545
80MP0003690_abnormal_glial_cell0.36175991
81MP0003183_abnormal_peptide_metabolism0.34702681
82MP0000249_abnormal_blood_vessel0.33795727
83MP0006292_abnormal_olfactory_placode0.33578988
84MP0004883_abnormal_blood_vessel0.33014610
85MP0005164_abnormal_response_to0.32943095
86MP0000678_abnormal_parathyroid_gland0.32148141
87MP0003123_paternal_imprinting0.28886725
88MP0009785_altered_susceptibility_to0.26517564
89MP0005647_abnormal_sex_gland0.26384287
90MP0005166_decreased_susceptibility_to0.25876691
91MP0005646_abnormal_pituitary_gland0.24858539
92MP0003075_altered_response_to0.24830351
93MP0008874_decreased_physiological_sensi0.24286084
94MP0000467_abnormal_esophagus_morphology0.24043108
95MP0006036_abnormal_mitochondrial_physio0.23360588
96MP0005551_abnormal_eye_electrophysiolog0.22910664
97MP0002135_abnormal_kidney_morphology0.22312865
98MP0002909_abnormal_adrenal_gland0.21846206
99MP0003172_abnormal_lysosome_physiology0.20386659
100MP0004142_abnormal_muscle_tone0.19677885

Predicted human phenotypes

RankGene SetZ-score
1Prolonged partial thromboplastin time (HP:0003645)9.35240946
2Complement deficiency (HP:0004431)9.23130899
3Abnormality of monocarboxylic acid metabolism (HP:0010996)9.11981651
4Hypobetalipoproteinemia (HP:0003563)8.05729418
5Abnormality of aromatic amino acid family metabolism (HP:0004338)8.01405418
6Abnormality of complement system (HP:0005339)7.30398472
7Joint hemorrhage (HP:0005261)6.68502528
8Conjugated hyperbilirubinemia (HP:0002908)6.22405414
9Systemic lupus erythematosus (HP:0002725)6.06296041
10Hyperlipoproteinemia (HP:0010980)5.20898673
11Xanthomatosis (HP:0000991)5.18387701
12Glomerulonephritis (HP:0000099)5.16089499
13Abnormality of the common coagulation pathway (HP:0010990)4.95752792
14Hypolipoproteinemia (HP:0010981)4.79544783
15Intrahepatic cholestasis (HP:0001406)4.67712246
16Spontaneous abortion (HP:0005268)4.37452447
17Recurrent gram-negative bacterial infections (HP:0005420)4.12228459
18Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.09527252
19Abnormality of glutamine family amino acid metabolism (HP:0010902)3.87974454
20Abnormality of the intrinsic pathway (HP:0010989)3.83831254
21Abnormality of pyrimidine metabolism (HP:0004353)3.80443105
22Nephritis (HP:0000123)3.60318971
23Hypercholesterolemia (HP:0003124)3.56010920
24Fat malabsorption (HP:0002630)3.53206965
25Hyperglycinemia (HP:0002154)3.39776834
26Vascular calcification (HP:0004934)3.26052059
27Epidermoid cyst (HP:0200040)3.24934522
28Hypoalphalipoproteinemia (HP:0003233)3.22634377
29Hemorrhage of the eye (HP:0011885)3.14828194
30Abnormality of glycine metabolism (HP:0010895)3.07454774
31Abnormality of serine family amino acid metabolism (HP:0010894)3.07454774
32Abnormality of methionine metabolism (HP:0010901)3.04119743
33Osteomalacia (HP:0002749)3.03871133
34Rickets (HP:0002748)2.96396066
35Gingival bleeding (HP:0000225)2.86042380
36Cardiovascular calcification (HP:0011915)2.85345102
37Hyperammonemia (HP:0001987)2.84520431
38Menorrhagia (HP:0000132)2.82160892
39Generalized aminoaciduria (HP:0002909)2.77605660
40Delayed CNS myelination (HP:0002188)2.77282586
41Mitral stenosis (HP:0001718)2.77189611
42Purpura (HP:0000979)2.74293846
43Hyperglycinuria (HP:0003108)2.73938765
44Abnormality of aspartate family amino acid metabolism (HP:0010899)2.58301980
45Thrombophlebitis (HP:0004418)2.56388160
46Steatorrhea (HP:0002570)2.47500548
47Abnormality of nucleobase metabolism (HP:0010932)2.46366326
48Fair hair (HP:0002286)2.43869952
49Abnormality of serum amino acid levels (HP:0003112)2.35277014
50Acanthocytosis (HP:0001927)2.34649352
51Hepatocellular carcinoma (HP:0001402)2.30226672
52Hypophosphatemic rickets (HP:0004912)2.27810941
53Hyperbilirubinemia (HP:0002904)2.27305457
54Abnormality of sulfur amino acid metabolism (HP:0004339)2.27007760
55Hyperphosphaturia (HP:0003109)2.23809714
56Arthropathy (HP:0003040)2.21961118
57Abnormality of vitamin metabolism (HP:0100508)2.18646715
58Pulmonary embolism (HP:0002204)2.18247639
59Poikilocytosis (HP:0004447)2.16907732
60Glycosuria (HP:0003076)2.13876369
61Abnormality of urine glucose concentration (HP:0011016)2.13876369
62Hydroxyprolinuria (HP:0003080)2.06964218
63Abnormality of proline metabolism (HP:0010907)2.06964218
64Bifid scrotum (HP:0000048)2.02133168
65Metabolic acidosis (HP:0001942)2.00247457
66Deep venous thrombosis (HP:0002625)10.6417272
67Abnormality of the Achilles tendon (HP:0005109)1.94412768
68Neonatal hypoglycemia (HP:0001998)1.94188291
69Enlarged kidneys (HP:0000105)1.91967251
70Ketosis (HP:0001946)1.91677560
71Skin nodule (HP:0200036)1.89902094
72Abnormal urine phosphate concentration (HP:0012599)1.88741707
73Myocardial infarction (HP:0001658)1.87627131
74Abnormality of purine metabolism (HP:0004352)1.84914469
75Gout (HP:0001997)1.80302154
76Reduced antithrombin III activity (HP:0001976)1.79550941
77Facial shape deformation (HP:0011334)1.75608335
78Potter facies (HP:0002009)1.75608335
79Irritability (HP:0000737)1.72587428
80Abnormal tarsal ossification (HP:0008369)1.72523386
81Joint swelling (HP:0001386)1.70983626
82Alkalosis (HP:0001948)1.64769985
83Hypoglycemic coma (HP:0001325)1.64737656
84Elevated alkaline phosphatase (HP:0003155)1.60959188
85Abnormality of iron homeostasis (HP:0011031)1.59190774
86Generalized hypopigmentation of hair (HP:0011358)1.58965382
87Epistaxis (HP:0000421)1.58430324
88Abnormal enzyme/coenzyme activity (HP:0012379)1.57344463
89Gangrene (HP:0100758)1.56337136
90Abnormality of transition element cation homeostasis (HP:0011030)1.55060607
91Increased serum ferritin (HP:0003281)1.54784079
92Increased mean platelet volume (HP:0011877)1.54623521
93Abnormality of alkaline phosphatase activity (HP:0004379)1.53597981
94Proximal tubulopathy (HP:0000114)1.52092984
95Abnormality of carpal bone ossification (HP:0006257)1.48971336
96Blue irides (HP:0000635)1.47452144
97Hypophosphatemia (HP:0002148)1.46500894
98Increased serum pyruvate (HP:0003542)1.45769404
99Pigmentary retinal degeneration (HP:0001146)1.44876606
100Hypochromic anemia (HP:0001931)1.44876069

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FGFR46.36602040
2FGFR34.33401742
3ERN13.58524327
4PIK3CA3.45726243
5RIPK12.81585042
6WNK42.73204675
7ICK2.14649563
8PRKAA21.99954364
9BCKDK1.94914138
10AKT31.93888551
11MAPK111.89038155
12PRKACG1.77630535
13FGFR21.69334526
14TGFBR21.64472145
15ERBB21.60074986
16EPHA41.53309123
17SIK11.52396286
18ACVR1B1.51274059
19TRIB31.51199191
20TYK21.50088437
21LATS11.46802174
22MAP3K21.44726020
23DYRK1B1.42614144
24MST1R1.40272029
25PDPK11.29844570
26EPHA31.29584334
27FGFR11.28649967
28NEK91.28233015
29SGK2231.27706835
30SGK4941.27706835
31NTRK31.27517447
32MAPK151.25906700
33MAP2K41.24747924
34IGF1R1.21828971
35CDK121.17848756
36PRKCG1.14782890
37RET1.12396477
38PINK11.12111757
39NLK1.10754414
40PIK3CG1.07571053
41MAPKAPK31.06740962
42EPHA21.04099221
43STK391.02422372
44STK161.02094560
45PKN20.99667174
46SGK20.97846085
47PDK10.96988456
48PRKCZ0.96155025
49SGK10.94477765
50GRK10.93672586
51WNK30.92377576
52PRKAA10.87671115
53SGK30.86126162
54PRKACA0.84959118
55PRKG10.84562864
56BRSK20.81841900
57EIF2AK10.80052753
58CSNK1E0.74344305
59CSF1R0.72963142
60MAP3K30.70857740
61MAP4K20.70683158
62WNK10.69009414
63RPS6KB10.68428970
64TYRO30.66635006
65FER0.62446467
66ABL20.61056124
67DDR20.60033428
68SRC0.58240603
69FRK0.57902814
70INSRR0.57749442
71PTK60.56957107
72PDGFRA0.56477016
73RPS6KA30.54733446
74CSNK1D0.54713489
75TAOK30.51878754
76CAMKK20.51312727
77PRKCA0.51292676
78MATK0.49744101
79PRKCB0.49143779
80BCR0.48383871
81CSNK2A10.47612071
82MAP3K10.47483199
83CDK90.46035403
84SIK20.44840037
85CDC42BPA0.44327070
86TIE10.43880305
87CDK60.41934150
88MAP2K60.40596338
89JAK20.39970968
90CSNK2A20.37876544
91CSNK1A10.37110215
92PRKG20.36621436
93MET0.35283293
94MAP3K110.34309746
95CDK70.33854913
96MAP3K120.33693562
97MAP3K50.33540574
98GRK60.33031976
99JAK10.31610255
100PRKACB0.30961939

Predicted pathways (KEGG)

RankGene SetZ-score
1Caffeine metabolism_Homo sapiens_hsa002324.41604988
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004004.05713588
3Complement and coagulation cascades_Homo sapiens_hsa046104.01285101
4Primary bile acid biosynthesis_Homo sapiens_hsa001203.58516364
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.49557432
6* Drug metabolism - cytochrome P450_Homo sapiens_hsa009823.31773430
7* Retinol metabolism_Homo sapiens_hsa008303.22567864
8* Chemical carcinogenesis_Homo sapiens_hsa052042.87150452
9* Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.82207350
10Pentose and glucuronate interconversions_Homo sapiens_hsa000402.70779293
11Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.58750865
12Phenylalanine metabolism_Homo sapiens_hsa003602.52067006
13Steroid hormone biosynthesis_Homo sapiens_hsa001402.51722417
14* Fatty acid degradation_Homo sapiens_hsa000712.51609730
15Arginine biosynthesis_Homo sapiens_hsa002202.51540944
16Drug metabolism - other enzymes_Homo sapiens_hsa009832.45960182
17Histidine metabolism_Homo sapiens_hsa003402.35449102
18* Tyrosine metabolism_Homo sapiens_hsa003502.17805473
19Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.98417806
20Butanoate metabolism_Homo sapiens_hsa006501.95224861
21Tryptophan metabolism_Homo sapiens_hsa003801.81723475
22Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.74632791
23Bile secretion_Homo sapiens_hsa049761.74239044
24Starch and sucrose metabolism_Homo sapiens_hsa005001.71168705
25Linoleic acid metabolism_Homo sapiens_hsa005911.68541188
26Cyanoamino acid metabolism_Homo sapiens_hsa004601.64175023
27PPAR signaling pathway_Homo sapiens_hsa033201.53274213
28Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.44245808
29Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.40694410
30Fat digestion and absorption_Homo sapiens_hsa049751.36202793
31Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.32951766
32Staphylococcus aureus infection_Homo sapiens_hsa051501.32214081
33Peroxisome_Homo sapiens_hsa041461.29942053
34beta-Alanine metabolism_Homo sapiens_hsa004101.24280637
35Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.17973672
36Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.15256198
37Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.12993827
38Vitamin B6 metabolism_Homo sapiens_hsa007501.10804114
39Arginine and proline metabolism_Homo sapiens_hsa003301.07357956
40Cysteine and methionine metabolism_Homo sapiens_hsa002701.06871174
41Arachidonic acid metabolism_Homo sapiens_hsa005901.01070337
42Prion diseases_Homo sapiens_hsa050200.98994837
43Pyruvate metabolism_Homo sapiens_hsa006200.98462471
44Biosynthesis of amino acids_Homo sapiens_hsa012300.97590240
45Maturity onset diabetes of the young_Homo sapiens_hsa049500.95540136
46Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.93425468
47Propanoate metabolism_Homo sapiens_hsa006400.93410179
48Fatty acid metabolism_Homo sapiens_hsa012120.91117741
49ABC transporters_Homo sapiens_hsa020100.89887856
502-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.89357008
51* Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.79003622
52Carbon metabolism_Homo sapiens_hsa012000.73528809
53Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.72076470
54One carbon pool by folate_Homo sapiens_hsa006700.72020232
55Vitamin digestion and absorption_Homo sapiens_hsa049770.63604444
56Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.59330469
57Sulfur metabolism_Homo sapiens_hsa009200.51243305
58Glycerolipid metabolism_Homo sapiens_hsa005610.48959595
59Lysine degradation_Homo sapiens_hsa003100.47630943
60* Metabolic pathways_Homo sapiens_hsa011000.44188640
61Steroid biosynthesis_Homo sapiens_hsa001000.43662601
62Sulfur relay system_Homo sapiens_hsa041220.37252255
63Renin-angiotensin system_Homo sapiens_hsa046140.32830032
64Fructose and mannose metabolism_Homo sapiens_hsa000510.31609007
65Fatty acid biosynthesis_Homo sapiens_hsa000610.30937866
66Pertussis_Homo sapiens_hsa051330.28140251
67Insulin resistance_Homo sapiens_hsa049310.26767517
68alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.26050274
69Mineral absorption_Homo sapiens_hsa049780.22228886
70Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.21156054
71Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.20194899
72Glutathione metabolism_Homo sapiens_hsa004800.18885697
73Glucagon signaling pathway_Homo sapiens_hsa049220.18527809
74Fatty acid elongation_Homo sapiens_hsa000620.18223256
75Galactose metabolism_Homo sapiens_hsa000520.13944188
76Glycosaminoglycan degradation_Homo sapiens_hsa005310.12258616
77Adipocytokine signaling pathway_Homo sapiens_hsa049200.10282594
78Systemic lupus erythematosus_Homo sapiens_hsa053220.08958310
79Pentose phosphate pathway_Homo sapiens_hsa000300.08506272
80Carbohydrate digestion and absorption_Homo sapiens_hsa049730.06471805
81Selenocompound metabolism_Homo sapiens_hsa004500.06432871
82Nitrogen metabolism_Homo sapiens_hsa009100.06200420
83Other glycan degradation_Homo sapiens_hsa005110.03871527
84AMPK signaling pathway_Homo sapiens_hsa041520.01165984
85Type II diabetes mellitus_Homo sapiens_hsa04930-0.2423094
86Ovarian steroidogenesis_Homo sapiens_hsa04913-0.1946257
87Circadian rhythm_Homo sapiens_hsa04710-0.1942084
88Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563-0.1866202
89Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.1785326
90Ether lipid metabolism_Homo sapiens_hsa00565-0.1686105
91Insulin signaling pathway_Homo sapiens_hsa04910-0.1668788
92Protein digestion and absorption_Homo sapiens_hsa04974-0.1157111
93Amoebiasis_Homo sapiens_hsa05146-0.1084962
94N-Glycan biosynthesis_Homo sapiens_hsa00510-0.0992092
95Sphingolipid metabolism_Homo sapiens_hsa00600-0.0983608
96African trypanosomiasis_Homo sapiens_hsa05143-0.0982486
97Serotonergic synapse_Homo sapiens_hsa04726-0.0790155
98Thyroid hormone synthesis_Homo sapiens_hsa04918-0.0717893
99Folate biosynthesis_Homo sapiens_hsa00790-0.0133400
100Glycerophospholipid metabolism_Homo sapiens_hsa00564-0.0115775

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