ADGRV1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the G-protein coupled receptor superfamily. The encoded protein contains a 7-transmembrane receptor domain, binds calcium and is expressed in the central nervous system. Mutations in this gene are associated with Usher syndrome 2 and familial febrile seizures. Several alternatively spliced transcripts have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of rhodopsin mediated signaling pathway (GO:0022400)7.66139996
2rhodopsin mediated signaling pathway (GO:0016056)7.48971901
3retinal cone cell development (GO:0046549)7.35145350
4photoreceptor cell maintenance (GO:0045494)6.60167585
5photoreceptor cell development (GO:0042461)5.80948549
6eye photoreceptor cell development (GO:0042462)5.74948924
7detection of light stimulus involved in visual perception (GO:0050908)5.60453672
8detection of light stimulus involved in sensory perception (GO:0050962)5.60453672
9retinal rod cell development (GO:0046548)5.41335640
10regulation of timing of cell differentiation (GO:0048505)4.84360566
11protein-chromophore linkage (GO:0018298)4.78494792
12regulation of development, heterochronic (GO:0040034)4.71861249
13phototransduction, visible light (GO:0007603)4.59658207
14neuron fate determination (GO:0048664)4.51946757
15detection of visible light (GO:0009584)4.51186681
16phototransduction (GO:0007602)4.47706665
17detection of light stimulus (GO:0009583)4.30598462
18nonmotile primary cilium assembly (GO:0035058)4.29188962
19visual perception (GO:0007601)4.27580834
20sensory perception of light stimulus (GO:0050953)4.25592426
21eye photoreceptor cell differentiation (GO:0001754)4.23354755
22photoreceptor cell differentiation (GO:0046530)4.23354755
23retina layer formation (GO:0010842)4.06391644
24cell morphogenesis involved in neuron differentiation (GO:0048667)3.71880237
25limb bud formation (GO:0060174)3.62056800
26negative regulation of astrocyte differentiation (GO:0048712)3.53875573
27retina development in camera-type eye (GO:0060041)3.46763779
28positive regulation of oligodendrocyte differentiation (GO:0048714)3.45047373
29cranial nerve morphogenesis (GO:0021602)3.43637746
30auditory behavior (GO:0031223)3.42776212
31regulation of cell maturation (GO:1903429)3.42349288
32regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.41923563
33response to pheromone (GO:0019236)3.36631042
34regulation of oligodendrocyte differentiation (GO:0048713)3.36101508
35axoneme assembly (GO:0035082)3.32643222
36cellular response to light stimulus (GO:0071482)3.32213657
37detection of abiotic stimulus (GO:0009582)3.27000678
38retinal ganglion cell axon guidance (GO:0031290)3.26562570
39pyrimidine nucleobase catabolic process (GO:0006208)3.25260477
40detection of external stimulus (GO:0009581)3.25218693
41cell proliferation in forebrain (GO:0021846)3.24694610
42presynaptic membrane assembly (GO:0097105)3.24527975
43left/right axis specification (GO:0070986)3.24175324
44righting reflex (GO:0060013)3.20851533
45startle response (GO:0001964)3.18616964
46cerebral cortex radially oriented cell migration (GO:0021799)3.17379567
47neurotransmitter-gated ion channel clustering (GO:0072578)3.12130383
48GMP metabolic process (GO:0046037)3.11167971
49mechanosensory behavior (GO:0007638)3.08933495
50astrocyte differentiation (GO:0048708)3.07163820
51limb development (GO:0060173)3.07128161
52appendage development (GO:0048736)3.07128161
53axon ensheathment in central nervous system (GO:0032291)3.07125163
54central nervous system myelination (GO:0022010)3.07125163
55forebrain neuron differentiation (GO:0021879)3.06656199
56protein heterotetramerization (GO:0051290)3.05895575
57dentate gyrus development (GO:0021542)3.05274044
58C4-dicarboxylate transport (GO:0015740)3.02790463
59response to auditory stimulus (GO:0010996)2.98035073
60lateral sprouting from an epithelium (GO:0060601)2.96078288
61microtubule depolymerization (GO:0007019)2.95442946
62protein localization to microtubule cytoskeleton (GO:0072698)2.92956122
63histone H3-K4 trimethylation (GO:0080182)2.91743204
64negative regulation of cytosolic calcium ion concentration (GO:0051481)2.90612469
65central nervous system neuron axonogenesis (GO:0021955)2.90283545
66negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.88290480
67negative regulation of translation, ncRNA-mediated (GO:0040033)2.88290480
68regulation of translation, ncRNA-mediated (GO:0045974)2.88290480
69cilium organization (GO:0044782)2.88277995
70DNA strand renaturation (GO:0000733)2.87270201
71negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.87122527
72male sex determination (GO:0030238)2.85938833
73cilium assembly (GO:0042384)2.85742541
74negative regulation of glial cell differentiation (GO:0045686)2.83765494
75artery development (GO:0060840)2.83702986
76somite development (GO:0061053)2.83022976
77negative regulation of oligodendrocyte differentiation (GO:0048715)2.81110663
78spinal cord motor neuron differentiation (GO:0021522)2.81031735
79cellular response to cholesterol (GO:0071397)2.80081280
80presynaptic membrane organization (GO:0097090)2.80056238
81pre-miRNA processing (GO:0031054)2.79954295
82establishment of nucleus localization (GO:0040023)2.78888465
83epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.77012271
84intraciliary transport (GO:0042073)2.76911700
85post-embryonic morphogenesis (GO:0009886)2.75812092
86cornea development in camera-type eye (GO:0061303)2.75189517
87positive regulation of guanylate cyclase activity (GO:0031284)2.74135042
88negative regulation of DNA-dependent DNA replication (GO:2000104)2.74092509
89olfactory bulb development (GO:0021772)2.73647044
90pancreas development (GO:0031016)2.73626912
91inner ear receptor stereocilium organization (GO:0060122)2.72703072
92kinetochore assembly (GO:0051382)2.72211164
93vocalization behavior (GO:0071625)2.72072005
94histone-serine phosphorylation (GO:0035404)2.68369762
95axonal fasciculation (GO:0007413)2.67074381
96cell fate commitment involved in formation of primary germ layer (GO:0060795)2.66379743
97neuronal stem cell maintenance (GO:0097150)2.66004791
98DNA integration (GO:0015074)2.65585586
99protein localization to synapse (GO:0035418)2.65005697
100regulation of mesenchymal cell apoptotic process (GO:2001053)2.64301514
101postsynaptic membrane organization (GO:0001941)2.64154653
102female gonad development (GO:0008585)2.63578196
103protein localization to cytoskeleton (GO:0044380)2.63023918
104dorsal/ventral axis specification (GO:0009950)2.62875926
105histone H3-K9 methylation (GO:0051567)2.62850887
106atrial cardiac muscle cell action potential (GO:0086014)2.61467140
107cilium or flagellum-dependent cell motility (GO:0001539)2.59749783
108central nervous system projection neuron axonogenesis (GO:0021952)2.57178174
109otic vesicle formation (GO:0030916)2.55942193
110smoothened signaling pathway (GO:0007224)2.55838795
111nucleobase catabolic process (GO:0046113)2.55208235
112face development (GO:0060324)2.53824329
113neuron development (GO:0048666)2.51700821
114replicative senescence (GO:0090399)2.51688266
115epithelial cell fate commitment (GO:0072148)2.49513785
116kinetochore organization (GO:0051383)2.48838036
117histone H2B ubiquitination (GO:0033523)2.48143108
118positive regulation of neuroblast proliferation (GO:0002052)2.47045956
119cellular response to radiation (GO:0071478)2.46301134
120calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.46209420
121cellular response to sterol (GO:0036315)2.45897748
122negative regulation of dendrite development (GO:2000171)2.45815655
123sensory perception (GO:0007600)2.45782307
124transmission of nerve impulse (GO:0019226)2.45743887
125innervation (GO:0060384)2.45296615
126regulation of glial cell differentiation (GO:0045685)2.45122632
127cell differentiation in spinal cord (GO:0021515)2.44331511
128epithelial cilium movement (GO:0003351)2.43046867
129neuron recognition (GO:0008038)2.42787518
130cilium movement (GO:0003341)2.41931913
131mitotic sister chromatid cohesion (GO:0007064)2.41910487
132positive regulation of synapse assembly (GO:0051965)2.41334988
133hindbrain development (GO:0030902)2.41077625
134cranial nerve development (GO:0021545)2.40647841
135G-protein coupled receptor internalization (GO:0002031)2.40453475
136neuron cell-cell adhesion (GO:0007158)2.39884576
137regulation of DNA endoreduplication (GO:0032875)2.39806213
138positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.39802501
139positive regulation of histone H3-K4 methylation (GO:0051571)2.39171288
140regulation of smoothened signaling pathway (GO:0008589)2.39080818
141cell-cell signaling involved in cell fate commitment (GO:0045168)2.39079107
142negative regulation of homotypic cell-cell adhesion (GO:0034111)2.38455424
143midbrain development (GO:0030901)2.37696485
144regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.37648954
145synaptic transmission, glutamatergic (GO:0035249)2.37430980
146nephron epithelium morphogenesis (GO:0072088)2.37306962
147nephron tubule morphogenesis (GO:0072078)2.37306962
148cell differentiation involved in kidney development (GO:0061005)2.37222103
149regulation of non-canonical Wnt signaling pathway (GO:2000050)2.36688672
150dendrite morphogenesis (GO:0048813)2.35795826
151centrosome localization (GO:0051642)2.35740417
152paraxial mesoderm development (GO:0048339)2.35657360
153ionotropic glutamate receptor signaling pathway (GO:0035235)2.35603849
154membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.35246692
155histone H3-K36 demethylation (GO:0070544)2.34927701
156proline transport (GO:0015824)2.34302546
157mesenchymal cell differentiation involved in kidney development (GO:0072161)2.34203329
158mesenchymal cell differentiation involved in renal system development (GO:2001012)2.34203329
159regulation of germinal center formation (GO:0002634)2.34182148
160regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.33381597
161cochlea development (GO:0090102)2.32036717
162positive regulation of neurological system process (GO:0031646)2.31767449
163regulation of centrosome cycle (GO:0046605)2.28384680
164neuron migration (GO:0001764)2.27629619

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human3.85761484
2EZH2_22144423_ChIP-Seq_EOC_Human2.89564160
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.82213305
4GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.81657879
5ZFP57_27257070_Chip-Seq_ESCs_Mouse2.43553792
6IGF1R_20145208_ChIP-Seq_DFB_Human2.39671402
7CBX2_27304074_Chip-Seq_ESCs_Mouse2.38118701
8BMI1_23680149_ChIP-Seq_NPCS_Mouse2.24835167
9EED_16625203_ChIP-ChIP_MESCs_Mouse2.23160905
10PCGF2_27294783_Chip-Seq_ESCs_Mouse2.17949430
11ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.15144982
12POU3F2_20337985_ChIP-ChIP_501MEL_Human2.14449087
13EZH2_27304074_Chip-Seq_ESCs_Mouse2.12807960
14TP63_19390658_ChIP-ChIP_HaCaT_Human2.11525298
15FLI1_27457419_Chip-Seq_LIVER_Mouse2.08508239
16SUZ12_27294783_Chip-Seq_NPCs_Mouse2.06160980
17BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.05498807
18RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.04686317
19SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.04022505
20SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.97651024
21HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.97620181
22VDR_22108803_ChIP-Seq_LS180_Human1.96054799
23JARID2_20064375_ChIP-Seq_MESCs_Mouse1.93676825
24NFE2_27457419_Chip-Seq_LIVER_Mouse1.93083903
25PCGF2_27294783_Chip-Seq_NPCs_Mouse1.91616457
26ZNF274_21170338_ChIP-Seq_K562_Hela1.90361447
27E2F7_22180533_ChIP-Seq_HELA_Human1.89934909
28TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.89256004
29P300_19829295_ChIP-Seq_ESCs_Human1.84843696
30PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.83096412
31MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.82479828
32RBPJ_22232070_ChIP-Seq_NCS_Mouse1.81713286
33SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.80077324
34CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.79857054
35CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.78546498
36RNF2_27304074_Chip-Seq_NSC_Mouse1.78176585
37NANOG_18555785_Chip-Seq_ESCs_Mouse1.77931226
38EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.77052330
39AR_21572438_ChIP-Seq_LNCaP_Human1.74889900
40FUS_26573619_Chip-Seq_HEK293_Human1.72042883
41NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.71383289
42POU5F1_16153702_ChIP-ChIP_HESCs_Human1.70126923
43CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.67915596
44PIAS1_25552417_ChIP-Seq_VCAP_Human1.67391087
45CTBP2_25329375_ChIP-Seq_LNCAP_Human1.66743074
46EZH2_27294783_Chip-Seq_NPCs_Mouse1.65410671
47E2F1_18555785_Chip-Seq_ESCs_Mouse1.65065400
48SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.64347201
49SMAD4_21799915_ChIP-Seq_A2780_Human1.60646460
50SUZ12_18555785_Chip-Seq_ESCs_Mouse1.58981684
51P53_22387025_ChIP-Seq_ESCs_Mouse1.58681269
52EZH2_27294783_Chip-Seq_ESCs_Mouse1.57171341
53SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.56481409
54JARID2_20075857_ChIP-Seq_MESCs_Mouse1.56376732
55EZH2_18974828_ChIP-Seq_MESCs_Mouse1.56220453
56RNF2_18974828_ChIP-Seq_MESCs_Mouse1.56220453
57RNF2_27304074_Chip-Seq_ESCs_Mouse1.55485622
58CTBP1_25329375_ChIP-Seq_LNCAP_Human1.54767857
59MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.54192502
60CMYC_18555785_Chip-Seq_ESCs_Mouse1.52245117
61EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.52214912
62PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.51657318
63SALL1_21062744_ChIP-ChIP_HESCs_Human1.50721179
64SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.50391197
65AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.49613455
66STAT3_18555785_Chip-Seq_ESCs_Mouse1.48077040
67SMAD3_21741376_ChIP-Seq_EPCs_Human1.47491345
68CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.45726716
69P300_18555785_Chip-Seq_ESCs_Mouse1.45510983
70TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.42681077
71POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.42681077
72TAF15_26573619_Chip-Seq_HEK293_Human1.41209204
73STAT3_23295773_ChIP-Seq_U87_Human1.39909502
74DROSHA_22980978_ChIP-Seq_HELA_Human1.39828313
75NMYC_18555785_Chip-Seq_ESCs_Mouse1.39407090
76OCT4_18555785_Chip-Seq_ESCs_Mouse1.36296454
77TOP2B_26459242_ChIP-Seq_MCF-7_Human1.35942058
78SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.35015671
79RUNX1_27457419_Chip-Seq_LIVER_Mouse1.34891041
80SUZ12_27294783_Chip-Seq_ESCs_Mouse1.34059710
81SOX2_18555785_Chip-Seq_ESCs_Mouse1.33259867
82ER_23166858_ChIP-Seq_MCF-7_Human1.32529710
83CBP_20019798_ChIP-Seq_JUKART_Human1.31967296
84IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.31967296
85ZFX_18555785_Chip-Seq_ESCs_Mouse1.30397076
86TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.30134979
87EWS_26573619_Chip-Seq_HEK293_Human1.28358035
88ESRRB_18555785_Chip-Seq_ESCs_Mouse1.27342434
89FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.26783060
90SOX9_26525672_Chip-Seq_HEART_Mouse1.26389952
91KLF4_18555785_Chip-Seq_ESCs_Mouse1.25763402
92E2F4_17652178_ChIP-ChIP_JURKAT_Human1.24889105
93TAL1_26923725_Chip-Seq_HPCs_Mouse1.24188333
94CTCF_18555785_Chip-Seq_ESCs_Mouse1.22730956
95BCAT_22108803_ChIP-Seq_LS180_Human1.22639072
96CDX2_19796622_ChIP-Seq_MESCs_Mouse1.22045103
97SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.21559547
98REST_21632747_ChIP-Seq_MESCs_Mouse1.21491457
99TCF4_23295773_ChIP-Seq_U87_Human1.21362494
100PU1_27457419_Chip-Seq_LIVER_Mouse1.21302713
101CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.20715369
102MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.20473652
103TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.20451679
104SOX2_16153702_ChIP-ChIP_HESCs_Human1.19560376
105MTF2_20144788_ChIP-Seq_MESCs_Mouse1.19549289
106UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.19415162
107AR_25329375_ChIP-Seq_VCAP_Human1.18781196
108TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17666391
109OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.16461158
110JUN_21703547_ChIP-Seq_K562_Human1.15726953
111P53_22127205_ChIP-Seq_FIBROBLAST_Human1.15614721
112OCT4_21477851_ChIP-Seq_ESCs_Mouse1.14579783
113RUNX2_22187159_ChIP-Seq_PCA_Human1.14313245
114SOX2_21211035_ChIP-Seq_LN229_Gbm1.14043659
115STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.13847019
116NR3C1_21868756_ChIP-Seq_MCF10A_Human1.13071864
117KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.12972800
118CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.12122465
119SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.12094679
120ARNT_22903824_ChIP-Seq_MCF-7_Human1.11861673
121LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11655800
122TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.11463730
123SMAD1_18555785_Chip-Seq_ESCs_Mouse1.10655181
124KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.08384319
125TCF4_22108803_ChIP-Seq_LS180_Human1.07843791
126FOXM1_23109430_ChIP-Seq_U2OS_Human1.07255473
127PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.06723366
128YAP1_20516196_ChIP-Seq_MESCs_Mouse1.06206797
129KLF5_20875108_ChIP-Seq_MESCs_Mouse1.01051711
130HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.00819687
131TP53_16413492_ChIP-PET_HCT116_Human0.99741906

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003011_delayed_dark_adaptation5.02568669
2MP0005551_abnormal_eye_electrophysiolog4.99789528
3MP0006292_abnormal_olfactory_placode4.00577650
4MP0005253_abnormal_eye_physiology3.97560212
5MP0006072_abnormal_retinal_apoptosis3.97330432
6MP0000566_synostosis3.65668617
7MP0002102_abnormal_ear_morphology2.93050582
8MP0001188_hyperpigmentation2.82771943
9MP0003136_yellow_coat_color2.35764351
10MP0005391_vision/eye_phenotype2.27988015
11MP0005195_abnormal_posterior_eye2.25541614
12MP0002638_abnormal_pupillary_reflex2.14941701
13MP0000569_abnormal_digit_pigmentation2.06611514
14MP0008789_abnormal_olfactory_epithelium2.04602929
15MP0004270_analgesia1.93713468
16MP0005423_abnormal_somatic_nervous1.93072310
17MP0001324_abnormal_eye_pigmentation1.90517551
18MP0002234_abnormal_pharynx_morphology1.86799002
19MP0004859_abnormal_synaptic_plasticity1.86650029
20MP0003787_abnormal_imprinting1.86270367
21MP0002822_catalepsy1.83768447
22MP0005394_taste/olfaction_phenotype1.80143907
23MP0005499_abnormal_olfactory_system1.80143907
24MP0003890_abnormal_embryonic-extraembry1.79932483
25MP0000778_abnormal_nervous_system1.75611309
26MP0000631_abnormal_neuroendocrine_gland1.75518711
27MP0000537_abnormal_urethra_morphology1.75376074
28MP0001486_abnormal_startle_reflex1.74926826
29MP0001984_abnormal_olfaction1.73545659
30MP0003950_abnormal_plasma_membrane1.70173497
31MP0002249_abnormal_larynx_morphology1.69926527
32MP0003283_abnormal_digestive_organ1.69386138
33MP0000049_abnormal_middle_ear1.62880217
34MP0002752_abnormal_somatic_nervous1.59039756
35MP0000026_abnormal_inner_ear1.56677163
36MP0005248_abnormal_Harderian_gland1.56088900
37MP0008058_abnormal_DNA_repair1.52978543
38MP0010030_abnormal_orbit_morphology1.52825973
39MP0003635_abnormal_synaptic_transmissio1.52165973
40MP0000955_abnormal_spinal_cord1.48575466
41MP0005646_abnormal_pituitary_gland1.44404927
42MP0005171_absent_coat_pigmentation1.41571052
43MP0003119_abnormal_digestive_system1.40311170
44MP0002653_abnormal_ependyma_morphology1.38944556
45MP0002063_abnormal_learning/memory/cond1.38923321
46MP0009780_abnormal_chondrocyte_physiolo1.38517425
47MP0003938_abnormal_ear_development1.37799273
48MP0002277_abnormal_respiratory_mucosa1.37142822
49MP0001986_abnormal_taste_sensitivity1.36580763
50MP0004742_abnormal_vestibular_system1.36012017
51MP0001502_abnormal_circadian_rhythm1.34729010
52MP0002734_abnormal_mechanical_nocicepti1.33960264
53MP0005409_darkened_coat_color1.33459248
54MP0001485_abnormal_pinna_reflex1.33242244
55MP0005187_abnormal_penis_morphology1.32313172
56MP0005645_abnormal_hypothalamus_physiol1.30497483
57MP0001286_abnormal_eye_development1.29128212
58MP0004133_heterotaxia1.25509792
59MP0000428_abnormal_craniofacial_morphol1.23228367
60MP0002938_white_spotting1.21822176
61MP0000383_abnormal_hair_follicle1.21240929
62MP0002090_abnormal_vision1.19698878
63MP0002064_seizures1.19165491
64MP0003941_abnormal_skin_development1.17685315
65MP0003121_genomic_imprinting1.16133165
66MP0003693_abnormal_embryo_hatching1.14944841
67MP0002882_abnormal_neuron_morphology1.13057087
68MP0002272_abnormal_nervous_system1.12851150
69MP0002233_abnormal_nose_morphology1.12461995
70MP0003937_abnormal_limbs/digits/tail_de1.11138838
71MP0002697_abnormal_eye_size1.11099111
72MP0001963_abnormal_hearing_physiology1.10784857
73MP0001346_abnormal_lacrimal_gland1.10419729
74MP0002229_neurodegeneration1.10125226
75MP0002282_abnormal_trachea_morphology1.07983715
76MP0005386_behavior/neurological_phenoty1.07171312
77MP0004924_abnormal_behavior1.07171312
78MP0001293_anophthalmia1.06058202
79MP0010678_abnormal_skin_adnexa1.05596686
80MP0009053_abnormal_anal_canal1.03109052
81MP0003878_abnormal_ear_physiology1.01990595
82MP0005377_hearing/vestibular/ear_phenot1.01990595
83MP0005379_endocrine/exocrine_gland_phen1.01301217
84MP0002751_abnormal_autonomic_nervous0.98763786
85MP0004381_abnormal_hair_follicle0.96598568
86MP0003880_abnormal_central_pattern0.95010387
87MP0003755_abnormal_palate_morphology0.94469635
88MP0002557_abnormal_social/conspecific_i0.93193423
89MP0002116_abnormal_craniofacial_bone0.92998375
90MP0002067_abnormal_sensory_capabilities0.92809912
91MP0008877_abnormal_DNA_methylation0.90388105
92MP0002735_abnormal_chemical_nociception0.90246796
93MP0005257_abnormal_intraocular_pressure0.88718477
94MP0000534_abnormal_ureter_morphology0.88186021
95MP0002111_abnormal_tail_morphology0.87692249
96MP0000015_abnormal_ear_pigmentation0.86255314
97MP0000647_abnormal_sebaceous_gland0.86186280
98MP0001970_abnormal_pain_threshold0.85149149
99MP0000678_abnormal_parathyroid_gland0.84361568
100MP0001968_abnormal_touch/_nociception0.82594965
101MP0000579_abnormal_nail_morphology0.82365055
102MP0003861_abnormal_nervous_system0.81381244
103MP0002184_abnormal_innervation0.80922036
104MP0002177_abnormal_outer_ear0.80420204
105MP0003122_maternal_imprinting0.79654162
106MP0009697_abnormal_copulation0.76333147
107MP0001299_abnormal_eye_distance/0.75807956
108MP0008057_abnormal_DNA_replication0.74294194
109MP0002572_abnormal_emotion/affect_behav0.73762994
110MP0000462_abnormal_digestive_system0.73420217
111MP0000613_abnormal_salivary_gland0.73114779
112MP0002736_abnormal_nociception_after0.72733562
113MP0008995_early_reproductive_senescence0.71679812
114MP0001529_abnormal_vocalization0.71264575
115MP0004142_abnormal_muscle_tone0.69753380
116MP0010094_abnormal_chromosome_stability0.69552498
117MP0003698_abnormal_male_reproductive0.69428965
118MP0002152_abnormal_brain_morphology0.68783672
119MP0003935_abnormal_craniofacial_develop0.68383705
120MP0006276_abnormal_autonomic_nervous0.67563305
121MP0009250_abnormal_appendicular_skeleto0.65992981
122MP0000432_abnormal_head_morphology0.64651045
123MP0009046_muscle_twitch0.64162149
124MP0005197_abnormal_uvea_morphology0.64028485
125MP0009745_abnormal_behavioral_response0.62898951
126MP0004885_abnormal_endolymph0.62528905
127MP0003942_abnormal_urinary_system0.62471464

Predicted human phenotypes

RankGene SetZ-score
1Congenital stationary night blindness (HP:0007642)8.85571276
2Bony spicule pigmentary retinopathy (HP:0007737)6.18851254
3Dyschromatopsia (HP:0007641)5.06410202
4Absent rod-and cone-mediated responses on ERG (HP:0007688)4.95613207
5Abnormal rod and cone electroretinograms (HP:0008323)4.79324387
6Abnormality of macular pigmentation (HP:0008002)4.58274209
7Pendular nystagmus (HP:0012043)4.49549677
8Attenuation of retinal blood vessels (HP:0007843)4.43596434
9Central scotoma (HP:0000603)4.37001791
10Decreased central vision (HP:0007663)4.36715436
11Chromosomal breakage induced by crosslinking agents (HP:0003221)4.33824166
12Chorioretinal atrophy (HP:0000533)4.24212677
13Scotoma (HP:0000575)3.80120706
14Volvulus (HP:0002580)3.66704487
15Septo-optic dysplasia (HP:0100842)3.63105214
16Chromsome breakage (HP:0040012)3.62748326
17Pigmentary retinal degeneration (HP:0001146)3.55145914
18Severe visual impairment (HP:0001141)3.40076977
19Increased corneal curvature (HP:0100692)3.37656481
20Keratoconus (HP:0000563)3.37656481
21Abolished electroretinogram (ERG) (HP:0000550)3.31163171
22Photophobia (HP:0000613)3.11585867
23Vitreoretinal degeneration (HP:0000655)2.95587104
24True hermaphroditism (HP:0010459)2.93320440
25Type II diabetes mellitus (HP:0005978)2.86928363
26Cone-rod dystrophy (HP:0000548)2.86870698
27Hyperventilation (HP:0002883)2.73498022
28Febrile seizures (HP:0002373)2.72893759
29Hepatoblastoma (HP:0002884)2.68544409
30Abnormality of the labia minora (HP:0012880)2.65043551
31Colon cancer (HP:0003003)2.60048471
32Retinitis pigmentosa (HP:0000510)2.59976640
33Cutaneous finger syndactyly (HP:0010554)2.59347081
34Congenital sensorineural hearing impairment (HP:0008527)2.57331563
35Chronic hepatic failure (HP:0100626)2.56056995
36Medial flaring of the eyebrow (HP:0010747)2.55021371
37Tubulointerstitial nephritis (HP:0001970)2.50856935
38Nephronophthisis (HP:0000090)2.50170221
39Pancreatic fibrosis (HP:0100732)2.46375124
40Esophageal atresia (HP:0002032)2.45901600
41Congenital primary aphakia (HP:0007707)2.44971281
42Medulloblastoma (HP:0002885)2.44413412
43Focal motor seizures (HP:0011153)2.44181445
44Split foot (HP:0001839)2.41921218
45Gait imbalance (HP:0002141)2.40201251
46Gastrointestinal atresia (HP:0002589)2.38650098
47Abnormality of the parathyroid morphology (HP:0011766)2.37372498
48Aplasia/Hypoplasia of the uvula (HP:0010293)2.37249955
49Abnormality of the renal medulla (HP:0100957)2.36616808
50Aplasia/Hypoplasia of the sternum (HP:0006714)2.35193686
51Optic nerve hypoplasia (HP:0000609)2.33087544
52Hemiparesis (HP:0001269)2.30506362
53Papillary thyroid carcinoma (HP:0002895)2.28669876
54Dynein arm defect of respiratory motile cilia (HP:0012255)2.27971047
55Absent/shortened dynein arms (HP:0200106)2.27971047
56Nephrogenic diabetes insipidus (HP:0009806)2.27154639
57Anophthalmia (HP:0000528)2.24913965
58Oligodactyly (hands) (HP:0001180)2.22881638
59Pancreatic cysts (HP:0001737)2.21463052
60Abnormal ciliary motility (HP:0012262)2.20516020
61Hypoplasia of the fovea (HP:0007750)2.19181145
62Aplasia/Hypoplasia of the fovea (HP:0008060)2.19181145
63Constricted visual fields (HP:0001133)2.17969224
64Intestinal atresia (HP:0011100)2.17929811
65Preaxial hand polydactyly (HP:0001177)2.17179143
66Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.16193816
67Cutaneous syndactyly (HP:0012725)2.14874985
68Choroideremia (HP:0001139)2.14282773
69Macular degeneration (HP:0000608)2.14141389
70Megalencephaly (HP:0001355)2.12688862
71Abnormality of midbrain morphology (HP:0002418)2.11325325
72Molar tooth sign on MRI (HP:0002419)2.11325325
73Hemivertebrae (HP:0002937)2.09587684
74Midline defect of the nose (HP:0004122)2.09161458
75Morphological abnormality of the inner ear (HP:0011390)2.08472662
76Drooling (HP:0002307)2.08305877
77Nephroblastoma (Wilms tumor) (HP:0002667)2.07353788
78Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.06598320
79Short 4th metacarpal (HP:0010044)2.06598320
80Duplicated collecting system (HP:0000081)2.06204969
81Postaxial foot polydactyly (HP:0001830)2.01971005
82Progressive cerebellar ataxia (HP:0002073)2.01712679
83Preaxial foot polydactyly (HP:0001841)2.01100129
84Bifid tongue (HP:0010297)2.00955210
85Absent septum pellucidum (HP:0001331)2.00589747
86Abnormality of the renal collecting system (HP:0004742)1.99409246
87Congenital hepatic fibrosis (HP:0002612)1.99332914
88Increased nuchal translucency (HP:0010880)1.99161196
89Abnormality of the aortic arch (HP:0012303)1.96205120
90Aplasia/Hypoplasia of the lens (HP:0008063)1.94850370
91Cortical dysplasia (HP:0002539)1.94570282
92Postaxial hand polydactyly (HP:0001162)1.94098331
93Renal hypoplasia (HP:0000089)1.93977995
94Lissencephaly (HP:0001339)1.93006690
95Aplasia cutis congenita (HP:0001057)1.92978919
96Embryonal renal neoplasm (HP:0011794)1.92388967
97Ectopic kidney (HP:0000086)1.92202641
98Long clavicles (HP:0000890)1.91240690
99Abnormality of the ischium (HP:0003174)1.90827874
100Chorioretinal coloboma (HP:0000567)1.90507323
101Upper limb muscle weakness (HP:0003484)1.90420306
102Vaginal atresia (HP:0000148)1.90171126
103Abnormal respiratory motile cilium physiology (HP:0012261)1.89955886
104Abnormality of cochlea (HP:0000375)1.88755706
105Truncal obesity (HP:0001956)1.88739774
106Astigmatism (HP:0000483)1.88340731
107Sclerocornea (HP:0000647)1.87308972
108Posterior subcapsular cataract (HP:0007787)1.87070512
109Abnormality of the nasal septum (HP:0000419)1.86908051
110Birth length less than 3rd percentile (HP:0003561)1.86851756
111Genital tract atresia (HP:0001827)1.86803779
112Anencephaly (HP:0002323)1.84938297
113Abnormal respiratory epithelium morphology (HP:0012253)1.84673786
114Abnormal respiratory motile cilium morphology (HP:0005938)1.84673786
115Morphological abnormality of the middle ear (HP:0008609)1.84673255
116Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.84646552
117Abnormality of the fovea (HP:0000493)1.83655351
118Excessive salivation (HP:0003781)1.81743352
119Aplasia/Hypoplasia of the tongue (HP:0010295)1.81656613
120Protruding tongue (HP:0010808)1.81622259
121Bilateral microphthalmos (HP:0007633)1.81284119
122Rhabdomyosarcoma (HP:0002859)1.81107427
123Aplasia involving bones of the extremities (HP:0009825)1.80687977
124Aplasia involving bones of the upper limbs (HP:0009823)1.80687977
125Aplasia of the phalanges of the hand (HP:0009802)1.80687977
126Male pseudohermaphroditism (HP:0000037)1.80143946
127Abnormality of the septum pellucidum (HP:0007375)1.79902110
128Meckel diverticulum (HP:0002245)1.79868296
129Abnormal lung lobation (HP:0002101)1.79650413
130Cystic liver disease (HP:0006706)1.79385085
131Abnormality of DNA repair (HP:0003254)1.78071142
132Poor coordination (HP:0002370)1.77822272
133Abnormality of the 4th metacarpal (HP:0010012)1.76448877
134Micropenis (HP:0000054)1.76351987
135Abnormality of the carotid arteries (HP:0005344)1.76211336
136Abnormality of the ileum (HP:0001549)1.75448445
137Aplasia/Hypoplasia of the tibia (HP:0005772)1.74669507
138Cerebellar dysplasia (HP:0007033)1.74011080
139Oligodactyly (HP:0012165)1.73782384
140Broad-based gait (HP:0002136)1.73101707
141Bifid scrotum (HP:0000048)1.70985912
142Prostate neoplasm (HP:0100787)1.70884541
143Abnormality of the preputium (HP:0100587)1.70000900
144Lip pit (HP:0100267)1.69996064
145Rhinitis (HP:0012384)1.69638704
146Alacrima (HP:0000522)1.69620072
147Abnormal number of incisors (HP:0011064)1.69585272
148Hypoplastic iliac wings (HP:0002866)1.69115064
149Hyperglycinuria (HP:0003108)1.68594627
150Pachygyria (HP:0001302)1.68304605
151Aplasia involving forearm bones (HP:0009822)1.66931460
152Absent forearm bone (HP:0003953)1.66931460
153Broad foot (HP:0001769)1.66842513
154Abnormality of incisor morphology (HP:0011063)1.66680975
155Anal stenosis (HP:0002025)1.66378539
156Partial agenesis of the corpus callosum (HP:0001338)1.65176032
157Highly arched eyebrow (HP:0002553)1.65065523
158Osteomalacia (HP:0002749)1.64194890
159Growth hormone deficiency (HP:0000824)1.63265563
160Glioma (HP:0009733)1.62830939
161Impulsivity (HP:0100710)1.60501810

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K95.97395005
2GRK14.99084660
3CASK4.17824035
4INSRR3.00099645
5TNIK2.47883627
6EPHB22.35010194
7ZAK2.30994894
8TAF12.21517157
9MKNK22.06501471
10BRD42.06319133
11PBK1.88665653
12PINK11.87162852
13PRPF4B1.86128742
14STK161.84600362
15NTRK31.80531461
16EIF2AK21.77241786
17MAPK131.76529799
18SRPK11.76512451
19NEK61.69518167
20YES11.69158549
21TSSK61.61662247
22CDK31.57936175
23WEE11.50520792
24IRAK21.46367478
25SIK31.43845491
26NUAK11.42095293
27EPHA41.36884057
28MKNK11.35449894
29TXK1.32262418
30MARK11.32220575
31ERBB31.29278782
32PKN11.29012904
33MAPK71.28169820
34CCNB11.24310204
35CSNK1G11.20959580
36NTRK21.19524874
37IRAK11.18223566
38CSNK1G21.16403409
39BMPR1B1.12863590
40MAP2K71.10036977
41SGK21.09792142
42BCR1.08900783
43TLK11.07850511
44MAPK151.07835558
45TYRO31.06744777
46LATS11.05821884
47EPHA31.02442323
48ERBB21.01540467
49WNK31.00211654
50CAMK1G0.98915745
51CLK10.96827361
52MAP4K20.96803262
53CDK120.95271103
54ADRBK20.94713120
55CSNK1G30.94043560
56CAMK1D0.93623590
57AKT30.93047032
58STK38L0.91144990
59TAOK20.89163905
60SIK20.87921693
61TTK0.83774217
62CHEK20.83626195
63BRSK20.83098684
64ATR0.82886591
65DYRK1A0.82782683
66SGK4940.80304238
67SGK2230.80304238
68CDC70.79103723
69BUB10.75962816
70VRK10.75219530
71PNCK0.74371072
72ACVR1B0.73194718
73CDK90.71601854
74BLK0.71072198
75MAP3K140.70423702
76PASK0.67956390
77IRAK40.67364941
78PRKCG0.65027956
79PLK30.63858750
80SGK10.63593376
81UHMK10.60484440
82PRKCE0.59451025
83DYRK20.59280056
84PLK10.58866852
85ATM0.58818264
86IRAK30.58175463
87HIPK20.57217926
88PLK40.56900112
89CSNK1D0.56724712
90RPS6KA50.56458314
91FGFR10.56370584
92KSR10.55955689
93WNK40.53970714
94ADRBK10.53967812
95DYRK30.53292606
96FRK0.53052506
97RAF10.52257677
98PLK20.50030505
99BMPR20.49822829
100CDK10.49103633
101PRKD20.48737891
102GRK70.47952584
103AKT20.47491449
104MAP2K40.46977974
105MAPK140.46644459
106CDK80.46064961
107CHUK0.45744484
108CDK50.45724938
109PRKDC0.45275518
110FGFR20.45095189
111KSR20.44763669
112BRAF0.44667397
113GSK3B0.44532807
114PRKG10.44289155
115CSNK1A1L0.44074006
116CSNK1E0.43916729
117STK390.42290304
118AURKB0.42204550
119AKT10.42179602
120ICK0.42048728
121NLK0.41894641
122MAP3K40.40032508
123STK30.39815315
124DYRK1B0.39739472
125PIK3CA0.39428419
126PRKCB0.38731173
127AURKA0.36522247
128CHEK10.36356082
129ARAF0.35805284
130TGFBR10.35004134
131MINK10.34187281
132RPS6KA30.34030680
133SGK30.33484022
134CAMK2A0.31880638
135MAPKAPK50.31236816
136NEK90.31000794
137CSNK1A10.30304320
138CDK20.29202657
139RPS6KB10.27588910
140BRSK10.27564923

Predicted pathways (KEGG)

RankGene SetZ-score
1Fanconi anemia pathway_Homo sapiens_hsa034602.65425478
2Nicotine addiction_Homo sapiens_hsa050332.43267505
3Steroid biosynthesis_Homo sapiens_hsa001002.10800662
4Phototransduction_Homo sapiens_hsa0474410.8527442
5Butanoate metabolism_Homo sapiens_hsa006501.92430976
6Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.88188039
7Basal cell carcinoma_Homo sapiens_hsa052171.82351289
8Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.68109217
9Morphine addiction_Homo sapiens_hsa050321.55004099
10Vitamin B6 metabolism_Homo sapiens_hsa007501.54412766
11Propanoate metabolism_Homo sapiens_hsa006401.52318492
12Homologous recombination_Homo sapiens_hsa034401.46157301
13Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.45454213
14Axon guidance_Homo sapiens_hsa043601.42319968
15Serotonergic synapse_Homo sapiens_hsa047261.38802074
16Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.35512760
17Systemic lupus erythematosus_Homo sapiens_hsa053221.34930183
18Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.34796561
19Taste transduction_Homo sapiens_hsa047421.34504007
20GABAergic synapse_Homo sapiens_hsa047271.34071894
21Non-homologous end-joining_Homo sapiens_hsa034501.30548454
22Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.28789763
23Glutamatergic synapse_Homo sapiens_hsa047241.21624540
24Nitrogen metabolism_Homo sapiens_hsa009101.21596592
25Olfactory transduction_Homo sapiens_hsa047401.21377750
26Hedgehog signaling pathway_Homo sapiens_hsa043401.16652714
27Wnt signaling pathway_Homo sapiens_hsa043101.14996282
28Maturity onset diabetes of the young_Homo sapiens_hsa049501.13451082
29Oocyte meiosis_Homo sapiens_hsa041141.13147177
30Alcoholism_Homo sapiens_hsa050341.12727071
31Retinol metabolism_Homo sapiens_hsa008301.11203078
32Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.09330863
33Circadian rhythm_Homo sapiens_hsa047101.09001324
34Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.08708653
35Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.07167730
36Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.99351762
37Circadian entrainment_Homo sapiens_hsa047130.99142047
38ABC transporters_Homo sapiens_hsa020100.95004210
39Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.94900500
40RNA transport_Homo sapiens_hsa030130.93352672
41Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.92695689
42Lysine degradation_Homo sapiens_hsa003100.91755447
43Colorectal cancer_Homo sapiens_hsa052100.91254699
44Basal transcription factors_Homo sapiens_hsa030220.91010953
45Insulin secretion_Homo sapiens_hsa049110.90259226
46Sphingolipid metabolism_Homo sapiens_hsa006000.89785883
47Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.89636388
48Transcriptional misregulation in cancer_Homo sapiens_hsa052020.83264675
49Cholinergic synapse_Homo sapiens_hsa047250.82211955
50Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.80687672
51Cysteine and methionine metabolism_Homo sapiens_hsa002700.80671238
52mRNA surveillance pathway_Homo sapiens_hsa030150.78386056
53Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.78134694
54beta-Alanine metabolism_Homo sapiens_hsa004100.75883559
55Melanoma_Homo sapiens_hsa052180.75304916
56Hippo signaling pathway_Homo sapiens_hsa043900.74770103
57Selenocompound metabolism_Homo sapiens_hsa004500.74491666
58Long-term depression_Homo sapiens_hsa047300.73637545
59Tight junction_Homo sapiens_hsa045300.72327417
60Gap junction_Homo sapiens_hsa045400.71003933
61Purine metabolism_Homo sapiens_hsa002300.70907753
62Fatty acid biosynthesis_Homo sapiens_hsa000610.70427131
63Protein export_Homo sapiens_hsa030600.70085789
64Vitamin digestion and absorption_Homo sapiens_hsa049770.69661747
65Synaptic vesicle cycle_Homo sapiens_hsa047210.69548972
66Calcium signaling pathway_Homo sapiens_hsa040200.69272557
67Tryptophan metabolism_Homo sapiens_hsa003800.68987244
68Steroid hormone biosynthesis_Homo sapiens_hsa001400.68135229
69Endometrial cancer_Homo sapiens_hsa052130.67640128
70DNA replication_Homo sapiens_hsa030300.67622689
71Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.65982436
72Thyroid hormone synthesis_Homo sapiens_hsa049180.63655506
73Notch signaling pathway_Homo sapiens_hsa043300.62895476
74Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.62449001
75Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.62297173
76cAMP signaling pathway_Homo sapiens_hsa040240.61871443
77Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.61847345
78Huntingtons disease_Homo sapiens_hsa050160.61697087
79Estrogen signaling pathway_Homo sapiens_hsa049150.61353886
80Melanogenesis_Homo sapiens_hsa049160.61263649
81Ether lipid metabolism_Homo sapiens_hsa005650.60972711
82Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.60919935
83Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.59429201
84Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.59357785
85Autoimmune thyroid disease_Homo sapiens_hsa053200.58509244
86Fatty acid metabolism_Homo sapiens_hsa012120.57934724
87Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.56923084
88cGMP-PKG signaling pathway_Homo sapiens_hsa040220.56124328
89Ovarian steroidogenesis_Homo sapiens_hsa049130.54546566
90Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.53937792
91Oxytocin signaling pathway_Homo sapiens_hsa049210.53583788
92Type II diabetes mellitus_Homo sapiens_hsa049300.52516772
93Dopaminergic synapse_Homo sapiens_hsa047280.52010227
94Cocaine addiction_Homo sapiens_hsa050300.51436500
95Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.51075921
96Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.51057610
97Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.50094055
98Primary bile acid biosynthesis_Homo sapiens_hsa001200.49962473
99MicroRNAs in cancer_Homo sapiens_hsa052060.49662153
100Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.49427004
101Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.49379831
102RNA polymerase_Homo sapiens_hsa030200.48714686
103Ras signaling pathway_Homo sapiens_hsa040140.48480966
104Arachidonic acid metabolism_Homo sapiens_hsa005900.48128194
105Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.47845733
106Dorso-ventral axis formation_Homo sapiens_hsa043200.47583240
107Adherens junction_Homo sapiens_hsa045200.47456202
108Cell cycle_Homo sapiens_hsa041100.47323037
109ErbB signaling pathway_Homo sapiens_hsa040120.47037354
110Gastric acid secretion_Homo sapiens_hsa049710.46981522
111NF-kappa B signaling pathway_Homo sapiens_hsa040640.46620632
112Inositol phosphate metabolism_Homo sapiens_hsa005620.46291269
113Phosphatidylinositol signaling system_Homo sapiens_hsa040700.44551384
114Linoleic acid metabolism_Homo sapiens_hsa005910.42484896
115alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.40368428
116One carbon pool by folate_Homo sapiens_hsa006700.40070491
117Pathways in cancer_Homo sapiens_hsa052000.36465439
118Prostate cancer_Homo sapiens_hsa052150.36284700
119Renin secretion_Homo sapiens_hsa049240.34443281
120Spliceosome_Homo sapiens_hsa030400.33920098
121Nucleotide excision repair_Homo sapiens_hsa034200.33711750
122p53 signaling pathway_Homo sapiens_hsa041150.32649199
123Base excision repair_Homo sapiens_hsa034100.32489318
124Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.32254780
125RNA degradation_Homo sapiens_hsa030180.32100015
126Salivary secretion_Homo sapiens_hsa049700.31388815
127Thyroid hormone signaling pathway_Homo sapiens_hsa049190.31378550
128Amphetamine addiction_Homo sapiens_hsa050310.31121005
129Allograft rejection_Homo sapiens_hsa053300.31062477
130Graft-versus-host disease_Homo sapiens_hsa053320.30052146
131HTLV-I infection_Homo sapiens_hsa051660.30025284
132TGF-beta signaling pathway_Homo sapiens_hsa043500.29963346
133Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.29366453
134Asthma_Homo sapiens_hsa053100.27954224
135Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.26983453
136MAPK signaling pathway_Homo sapiens_hsa040100.26126277
137Mismatch repair_Homo sapiens_hsa034300.25622217
138Mineral absorption_Homo sapiens_hsa049780.25240661
139Aldosterone synthesis and secretion_Homo sapiens_hsa049250.24058609
140PI3K-Akt signaling pathway_Homo sapiens_hsa041510.23583403
141Carbohydrate digestion and absorption_Homo sapiens_hsa049730.23187862
142Rheumatoid arthritis_Homo sapiens_hsa053230.23038503

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