ADGRF5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1surfactant homeostasis (GO:0043129)7.80818517
2vascular endothelial growth factor signaling pathway (GO:0038084)6.59794912
3lymph vessel development (GO:0001945)6.44511817
4chemical homeostasis within a tissue (GO:0048875)6.29893593
5retina vasculature morphogenesis in camera-type eye (GO:0061299)5.23102670
6blood vessel maturation (GO:0001955)5.20337790
7cellular response to vascular endothelial growth factor stimulus (GO:0035924)5.11460631
8regulation of endothelial cell differentiation (GO:0045601)5.08488806
9positive regulation of vasculogenesis (GO:2001214)4.91921379
10lymphangiogenesis (GO:0001946)4.91435206
11endothelium development (GO:0003158)4.88591799
12regulation of vasculogenesis (GO:2001212)4.81285719
13endothelial tube morphogenesis (GO:0061154)4.56178297
14morphogenesis of an endothelium (GO:0003159)4.56178297
15renal filtration (GO:0097205)4.02012140
16glomerular filtration (GO:0003094)4.00977334
17cell migration involved in sprouting angiogenesis (GO:0002042)4.00064864
18vascular endothelial growth factor receptor signaling pathway (GO:0048010)3.96232017
19angiogenesis involved in wound healing (GO:0060055)3.95058262
20peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.90818920
21endothelial cell morphogenesis (GO:0001886)3.89862513
22Notch signaling involved in heart development (GO:0061314)3.77580961
23positive regulation of endothelial cell differentiation (GO:0045603)3.74982354
24endothelial cell differentiation (GO:0045446)3.74265013
25patterning of blood vessels (GO:0001569)3.66871090
26venous blood vessel morphogenesis (GO:0048845)3.64852893
27fatty acid transmembrane transport (GO:1902001)3.61896816
28negative regulation of complement activation (GO:0045916)3.56945485
29coronary vasculature morphogenesis (GO:0060977)3.56925363
30blood vessel endothelial cell migration (GO:0043534)3.56535805
31basement membrane organization (GO:0071711)3.52142274
32heart trabecula formation (GO:0060347)3.51891469
33ovulation from ovarian follicle (GO:0001542)3.51179919
34low-density lipoprotein particle clearance (GO:0034383)3.46161584
35transcytosis (GO:0045056)3.45036095
36protein localization to endosome (GO:0036010)3.40154712
37sprouting angiogenesis (GO:0002040)3.36035017
38negative regulation of Rho protein signal transduction (GO:0035024)3.28438641
39endothelial cell chemotaxis (GO:0035767)3.23919638
40regulation of integrin-mediated signaling pathway (GO:2001044)3.21955166
41neuron projection extension involved in neuron projection guidance (GO:1902284)3.19731045
42axon extension involved in axon guidance (GO:0048846)3.19731045
43wound healing, spreading of epidermal cells (GO:0035313)3.19386215
44peptidyl-tyrosine autophosphorylation (GO:0038083)3.19080056
45negative regulation of protein activation cascade (GO:2000258)3.17576581
46dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.16265639
47bundle of His cell to Purkinje myocyte communication (GO:0086069)3.08014609
48vasculogenesis (GO:0001570)3.04958071
49plasma membrane repair (GO:0001778)3.04840052
50negative regulation of blood vessel endothelial cell migration (GO:0043537)3.02684318
51blood vessel remodeling (GO:0001974)2.96548764
52negative regulation of endothelial cell migration (GO:0010596)2.95095525
53regulation of p38MAPK cascade (GO:1900744)2.93974874
54artery development (GO:0060840)2.90913817
55endocrine hormone secretion (GO:0060986)2.88018524
56neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.86260421
57regulation of blood vessel endothelial cell migration (GO:0043535)2.83268346
58carnitine shuttle (GO:0006853)2.82507358
59nephron epithelium development (GO:0072009)2.81947509
60glomerular visceral epithelial cell development (GO:0072015)2.81722064
61negative regulation of vascular permeability (GO:0043116)2.81605055
62substrate-dependent cell migration (GO:0006929)2.80859423
63regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.80145668
64regulation of cell migration involved in sprouting angiogenesis (GO:0090049)2.78112692
65regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030947)2.76535163
66cardiac myofibril assembly (GO:0055003)2.74523372
67negative regulation of endothelial cell proliferation (GO:0001937)2.74394656
68negative regulation of humoral immune response (GO:0002921)2.74260919
69negative regulation of actin filament bundle assembly (GO:0032232)2.74065373
70regulation of sequestering of triglyceride (GO:0010889)2.71958942
71regulation of axon extension involved in axon guidance (GO:0048841)2.71678380
72positive regulation of p38MAPK cascade (GO:1900745)2.71529122
73regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.69431276
74establishment of endothelial barrier (GO:0061028)2.69252063
75regulation of vascular permeability (GO:0043114)2.67452711
76cellular response to nitric oxide (GO:0071732)2.66842021
77positive regulation of focal adhesion assembly (GO:0051894)2.66470503
78positive regulation of cell junction assembly (GO:1901890)2.66470503
79cAMP biosynthetic process (GO:0006171)2.64883362
80regulation of glomerular filtration (GO:0003093)2.64050084
81endothelial cell proliferation (GO:0001935)2.63720536
82embryonic heart tube development (GO:0035050)2.63691649
83glomerular basement membrane development (GO:0032836)2.63160417
84glomerular epithelial cell development (GO:0072310)2.62055802
85negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)2.61123112
86cGMP-mediated signaling (GO:0019934)2.61120567
87endothelial cell migration (GO:0043542)2.60104535
88regulation of cholesterol storage (GO:0010885)2.58923688
89ventricular trabecula myocardium morphogenesis (GO:0003222)2.56497867
90negative regulation of endothelial cell apoptotic process (GO:2000352)2.55010057
91negative regulation of platelet activation (GO:0010544)2.54139283
92positive regulation of macrophage cytokine production (GO:0060907)2.53606128
93ganglion development (GO:0061548)2.52909767
94sarcomere organization (GO:0045214)2.51626026
95positive regulation of adherens junction organization (GO:1903393)2.51335209
96positive regulation of receptor recycling (GO:0001921)2.50025890
97hemidesmosome assembly (GO:0031581)2.49950062
98cell volume homeostasis (GO:0006884)2.49547268
99lung vasculature development (GO:0060426)2.48830873
100regulation of tight junction assembly (GO:2000810)2.47787597
101phosphate ion transmembrane transport (GO:0035435)2.47282474
102atrioventricular valve morphogenesis (GO:0003181)2.47253886
103regulation of endothelial cell migration (GO:0010594)2.47081282
104muscle filament sliding (GO:0030049)2.46971526
105actin-myosin filament sliding (GO:0033275)2.46971526
106negative regulation of angiogenesis (GO:0016525)2.46853209
107cell adhesion mediated by integrin (GO:0033627)2.46716252
108metanephric nephron epithelium development (GO:0072243)2.46309348
109positive regulation of glomerulus development (GO:0090193)2.45259427
110negative regulation of adherens junction organization (GO:1903392)2.45154299
111negative regulation of focal adhesion assembly (GO:0051895)2.45154299
112negative regulation of cell junction assembly (GO:1901889)2.45154299
113negative regulation of epithelial cell migration (GO:0010633)2.44373033
114negative regulation of nitric-oxide synthase activity (GO:0051001)2.44200431
115regulation of epithelial cell migration (GO:0010632)2.42072052
116negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.41616509
117positive regulation of endothelial cell proliferation (GO:0001938)2.41543066
118negative regulation of protein localization to cell surface (GO:2000009)2.40102774
119negative regulation of stress fiber assembly (GO:0051497)2.38751591
120apoptotic cell clearance (GO:0043277)2.38386560
121regulation of cardioblast differentiation (GO:0051890)2.37778020
122heart trabecula morphogenesis (GO:0061384)2.36415552
123negative regulation of blood vessel morphogenesis (GO:2000181)2.36327359
124cellular response to epinephrine stimulus (GO:0071872)2.35662719
125negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)2.34736749
126regulation of axon guidance (GO:1902667)2.34723629
127angiogenesis (GO:0001525)2.33599323
128myofibril assembly (GO:0030239)2.32436533
129regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.32434017
130metanephric epithelium development (GO:0072207)2.31943085
131cellular response to reactive nitrogen species (GO:1902170)2.31513177
132neuron remodeling (GO:0016322)2.31346843
133trabecula morphogenesis (GO:0061383)2.31070065
134sodium-independent organic anion transport (GO:0043252)2.30985323
135stress fiber assembly (GO:0043149)2.30794738
136fatty acid beta-oxidation (GO:0006635)2.30554811
137semaphorin-plexin signaling pathway (GO:0071526)2.30168016
138renal absorption (GO:0070293)2.29393173
139cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.28775749
140negative regulation of vasculature development (GO:1901343)2.28439023
141positive regulation of endothelial cell migration (GO:0010595)2.27864510
142regulation of complement activation (GO:0030449)2.27434970
143positive regulation of protein kinase C signaling (GO:0090037)2.27412592

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.79239405
2TRIM28_21343339_ChIP-Seq_HEK293_Human3.46724935
3GATA1_22025678_ChIP-Seq_K562_Human3.02481322
4CLOCK_20551151_ChIP-Seq_293T_Human2.98634992
5GATA2_21666600_ChIP-Seq_HMVEC_Human2.90880003
6ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.67325339
7EP300_21415370_ChIP-Seq_HL-1_Mouse2.50241986
8RARG_19884340_ChIP-ChIP_MEFs_Mouse2.41768213
9BP1_19119308_ChIP-ChIP_Hs578T_Human2.19972789
10LXR_22158963_ChIP-Seq_LIVER_Mouse2.19086500
11ESR2_21235772_ChIP-Seq_MCF-7_Human2.01130844
12RXR_22158963_ChIP-Seq_LIVER_Mouse1.99968329
13ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.98331341
14ESR1_20079471_ChIP-ChIP_T-47D_Human1.97607847
15TBX20_22080862_ChIP-Seq_HEART_Mouse1.97034496
16TBX20_22328084_ChIP-Seq_HEART_Mouse1.97034496
17CDX2_19796622_ChIP-Seq_MESCs_Mouse1.93987178
18TP63_17297297_ChIP-ChIP_HaCaT_Human1.91840083
19NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.89213922
20TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.80503199
21NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.79860717
22ESR1_21235772_ChIP-Seq_MCF-7_Human1.77362486
23PPAR_26484153_Chip-Seq_NCI-H1993_Human1.75864677
24PPARA_22158963_ChIP-Seq_LIVER_Mouse1.74916945
25TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.67275096
26ZNF217_24962896_ChIP-Seq_MCF-7_Human1.62345645
27FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.58402040
28STAT6_21828071_ChIP-Seq_BEAS2B_Human1.57728453
29TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.57498935
30EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.55045626
31THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.53231409
32BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.51526709
33STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.51331048
34CJUN_26792858_Chip-Seq_BT549_Human1.50791467
35FOXO3_23340844_ChIP-Seq_DLD1_Human1.49639996
36SALL4_18804426_ChIP-ChIP_XEN_Mouse1.47766253
37AHR_22903824_ChIP-Seq_MCF-7_Human1.46617238
38SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.44812064
39ZNF263_19887448_ChIP-Seq_K562_Human1.43664865
40SMAD_19615063_ChIP-ChIP_OVARY_Human1.43625725
41STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.43390325
42ELK3_25401928_ChIP-Seq_HUVEC_Human1.42919219
43KDM2B_26808549_Chip-Seq_SUP-B15_Human1.33298578
44GATA1_19941826_ChIP-Seq_K562_Human1.30116505
45HIF1A_21447827_ChIP-Seq_MCF-7_Human1.28270136
46SOX2_20726797_ChIP-Seq_SW620_Human1.25369649
47SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.24663222
48SOX9_24532713_ChIP-Seq_HFSC_Mouse1.24590143
49TCF4_18268006_ChIP-ChIP_LS174T_Human1.22882072
50GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.22100412
51CDX2_20551321_ChIP-Seq_CACO-2_Human1.21088663
52WT1_19549856_ChIP-ChIP_CCG9911_Human1.20734286
53TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.20683312
54FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.19789856
55FOXA2_19822575_ChIP-Seq_HepG2_Human1.19651407
56SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.18212262
57Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.14913206
58CTNNB1_20460455_ChIP-Seq_HCT116_Human1.14644979
59ARNT_22903824_ChIP-Seq_MCF-7_Human1.14201649
60RNF2_18974828_ChIP-Seq_MESCs_Mouse1.13613489
61EZH2_18974828_ChIP-Seq_MESCs_Mouse1.13613489
62FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.13527077
63KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.12464894
64MTF2_20144788_ChIP-Seq_MESCs_Mouse1.10646734
65NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.09084483
66NRF2_20460467_ChIP-Seq_MEFs_Mouse1.09084483
67PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.06237286
68CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.06233414
69PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.06185977
70KDM2B_26808549_Chip-Seq_K562_Human1.05367040
71NR3C1_23031785_ChIP-Seq_PC12_Mouse1.05252893
72WT1_25993318_ChIP-Seq_PODOCYTE_Human1.04825041
73CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.04749750
74EED_16625203_ChIP-ChIP_MESCs_Mouse1.03214644
75FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.02718127
76SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.01675985
77TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.01423080
78PIAS1_25552417_ChIP-Seq_VCAP_Human1.01013254
79SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.00921736
80ISL1_27105846_Chip-Seq_CPCs_Mouse1.00701360
81RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.99015507
82NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.98465657
83BCAT_22108803_ChIP-Seq_LS180_Human0.97156260
84SMAD3_21741376_ChIP-Seq_HESCs_Human0.95860152
85STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.95764476
86SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.94548852
87SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.94381763
88SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.94381763
89JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.93824543
90ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.93820015
91PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.93286717
92FOXM1_26456572_ChIP-Seq_MCF-7_Human0.92768359
93SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.92654025
94SMAD4_21741376_ChIP-Seq_HESCs_Human0.92620835
95AR_21572438_ChIP-Seq_LNCaP_Human0.91881382
96SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91315748
97BRD4_25478319_ChIP-Seq_HGPS_Human0.90460414
98WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.90349920
99JARID2_20075857_ChIP-Seq_MESCs_Mouse0.90140328
100NFIB_24661679_ChIP-Seq_LUNG_Mouse0.89704930
101SOX2_27498859_Chip-Seq_STOMACH_Mouse0.89396764
102RACK7_27058665_Chip-Seq_MCF-7_Human0.89076489
103AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.87873086
104GATA2_19941826_ChIP-Seq_K562_Human0.87459304
105RUNX1_27514584_Chip-Seq_MCF-7_Human0.86378420
106SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.85998109
107DROSHA_22980978_ChIP-Seq_HELA_Human0.85507535
108TP53_18474530_ChIP-ChIP_U2OS_Human0.85366013
109RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.85073856
110JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.84792929
111RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.84689913
112CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.84531843
113SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.84301345
114TP63_23658742_ChIP-Seq_EP156T_Human0.84026390

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010368_abnormal_lymphatic_system6.12290798
2MP0001879_abnormal_lymphatic_vessel4.83244549
3MP0005167_abnormal_blood-brain_barrier4.16648102
4MP0004272_abnormal_basement_membrane4.15662126
5MP0004084_abnormal_cardiac_muscle3.43888377
6MP0003724_increased_susceptibility_to2.91151583
7MP0003828_pulmonary_edema2.72135488
8MP0001958_emphysema2.55744949
9MP0004782_abnormal_surfactant_physiolog2.48442965
10MP0004036_abnormal_muscle_relaxation2.36736931
11MP0006138_congestive_heart_failure2.33967653
12MP0004215_abnormal_myocardial_fiber2.31572328
13MP0004130_abnormal_muscle_cell2.23890022
14MP0002138_abnormal_hepatobiliary_system2.22063771
15MP0002837_dystrophic_cardiac_calcinosis2.14882345
16MP0005670_abnormal_white_adipose1.99295270
17MP0008775_abnormal_heart_ventricle1.98261018
18MP0003705_abnormal_hypodermis_morpholog1.98225170
19MP0000751_myopathy1.92295627
20MP0005385_cardiovascular_system_phenoty1.84912505
21MP0001544_abnormal_cardiovascular_syste1.84912505
22MP0003191_abnormal_cellular_cholesterol1.81159044
23MP0000013_abnormal_adipose_tissue1.79134273
24MP0005330_cardiomyopathy1.77210925
25MP0004484_altered_response_of1.75460720
26MP0003566_abnormal_cell_adhesion1.74043971
27MP0000767_abnormal_smooth_muscle1.72044442
28MP0005165_increased_susceptibility_to1.65635558
29MP0000343_altered_response_to1.64240545
30MP0003279_aneurysm1.63058873
31MP0002295_abnormal_pulmonary_circulatio1.60427760
32MP0002972_abnormal_cardiac_muscle1.60242805
33MP0006054_spinal_hemorrhage1.57023884
34MP0000465_gastrointestinal_hemorrhage1.56058381
35MP0010630_abnormal_cardiac_muscle1.51952063
36MP0003950_abnormal_plasma_membrane1.50313604
37MP0005360_urolithiasis1.44788435
38MP0002332_abnormal_exercise_endurance1.44439983
39MP0005666_abnormal_adipose_tissue1.41195781
40MP0004185_abnormal_adipocyte_glucose1.41105824
41MP0005595_abnormal_vascular_smooth1.40707870
42MP0005620_abnormal_muscle_contractility1.39785504
43MP0000249_abnormal_blood_vessel1.38478610
44MP0005409_darkened_coat_color1.34909779
45MP0004085_abnormal_heartbeat1.34775297
46MP0004147_increased_porphyrin_level1.34326027
47MP0004087_abnormal_muscle_fiber1.34012221
48MP0002128_abnormal_blood_circulation1.30636119
49MP0005623_abnormal_meninges_morphology1.30042408
50MP0003300_gastrointestinal_ulcer1.28000994
51MP0008438_abnormal_cutaneous_collagen1.27674751
52MP0002133_abnormal_respiratory_system1.27561028
53MP0005388_respiratory_system_phenotype1.27561028
54MP0002127_abnormal_cardiovascular_syste1.27334189
55MP0000749_muscle_degeneration1.26291082
56MP0008995_early_reproductive_senescence1.23030046
57MP0002933_joint_inflammation1.18033808
58MP0005375_adipose_tissue_phenotype1.17508646
59MP0002925_abnormal_cardiovascular_devel1.17352577
60MP0008875_abnormal_xenobiotic_pharmacok1.16837713
61MP0010329_abnormal_lipoprotein_level1.16734711
62MP0000750_abnormal_muscle_regeneration1.15707365
63MP0003091_abnormal_cell_migration1.11363086
64MP0002108_abnormal_muscle_morphology1.10995916
65MP0005164_abnormal_response_to1.09536020
66MP0004145_abnormal_muscle_electrophysio1.07990426
67MP0001614_abnormal_blood_vessel1.06946044
68MP0005085_abnormal_gallbladder_physiolo1.06808549
69MP0005023_abnormal_wound_healing1.06797810
70MP0005503_abnormal_tendon_morphology1.06667092
71MP0000003_abnormal_adipose_tissue1.05765868
72MP0000230_abnormal_systemic_arterial1.04049286
73MP0009780_abnormal_chondrocyte_physiolo1.02361799
74MP0005275_abnormal_skin_tensile1.00720893
75MP0004883_abnormal_blood_vessel1.00048888
76MP0002877_abnormal_melanocyte_morpholog0.99470256
77MP0000747_muscle_weakness0.97495518
78MP0009278_abnormal_bone_marrow0.97084928
79MP0002139_abnormal_hepatobiliary_system0.96198345
80MP0004510_myositis0.95423199
81MP0003045_fibrosis0.95116935
82MP0000266_abnormal_heart_morphology0.93722261
83MP0008004_abnormal_stomach_pH0.93386002
84MP0005365_abnormal_bile_salt0.92687074
85MP0009840_abnormal_foam_cell0.91401968
86MP0003252_abnormal_bile_duct0.90469940
87MP0003690_abnormal_glial_cell0.90015776
88MP0003303_peritoneal_inflammation0.88384786
89MP0001756_abnormal_urination0.87398127
90MP0003646_muscle_fatigue0.86628509
91MP0010352_gastrointestinal_tract_polyps0.85995002
92MP0000733_abnormal_muscle_development0.84982757
93MP0002269_muscular_atrophy0.83593504
94MP0002106_abnormal_muscle_physiology0.82088681
95MP0002118_abnormal_lipid_homeostasis0.81195681
96MP0005083_abnormal_biliary_tract0.81110466
97MP0009643_abnormal_urine_homeostasis0.80477848
98MP0005187_abnormal_penis_morphology0.79195365
99MP0010234_abnormal_vibrissa_follicle0.78997844
100MP0001542_abnormal_bone_strength0.77415630
101MP0008961_abnormal_basal_metabolism0.76861548
102MP0002971_abnormal_brown_adipose0.73671198
103MP0002998_abnormal_bone_remodeling0.71938865
104MP0001915_intracranial_hemorrhage0.71729940
105MP0002896_abnormal_bone_mineralization0.71653667
106MP0001661_extended_life_span0.70915021
107MP0001784_abnormal_fluid_regulation0.68575486
108MP0001851_eye_inflammation0.67645715
109MP0005369_muscle_phenotype0.66566123
110MP0005166_decreased_susceptibility_to0.66040677
111MP0009115_abnormal_fat_cell0.65971674
112MP0000759_abnormal_skeletal_muscle0.63734487
113MP0003137_abnormal_impulse_conducting0.62611246
114MP0001177_atelectasis0.62428374
115MP0003948_abnormal_gas_homeostasis0.61864776
116MP0005084_abnormal_gallbladder_morpholo0.61520550
117MP0003567_abnormal_fetal_cardiomyocyte0.61042479
118MP0000537_abnormal_urethra_morphology0.60948317
119MP0002168_other_aberrant_phenotype0.60707706
120MP0009764_decreased_sensitivity_to0.60447489
121MP0001175_abnormal_lung_morphology0.60367779
122MP0000534_abnormal_ureter_morphology0.59465229
123MP0005319_abnormal_enzyme/_coenzyme0.59386023
124MP0003075_altered_response_to0.58135624

Predicted human phenotypes

RankGene SetZ-score
1Polycythemia (HP:0001901)6.44792304
2Hematochezia (HP:0002573)5.05994854
3Spontaneous hematomas (HP:0007420)4.52790615
4Esophageal varix (HP:0002040)4.49515710
5Muscle fiber splitting (HP:0003555)4.16900787
6Sudden death (HP:0001699)3.99690975
7Interstitial pulmonary disease (HP:0006530)3.81194105
8Hyporeflexia of lower limbs (HP:0002600)3.80053719
9Ventricular tachycardia (HP:0004756)3.76162815
10Increased connective tissue (HP:0009025)3.73812149
11Right ventricular cardiomyopathy (HP:0011663)3.71759895
12Broad metatarsal (HP:0001783)3.63785189
13Arterial tortuosity (HP:0005116)3.58133748
14Cerebral hemorrhage (HP:0001342)3.55627478
15Cerebral aneurysm (HP:0004944)3.53903282
16Deep venous thrombosis (HP:0002625)3.53341152
17Visceral angiomatosis (HP:0100761)3.52563221
18Vascular tortuosity (HP:0004948)3.52522135
19Difficulty running (HP:0009046)3.40989440
20Hemangiomatosis (HP:0007461)3.32546360
21Lymphangioma (HP:0100764)3.28360748
22Hyperactive renin-angiotensin system (HP:0000841)3.24533303
23Abnormality of the nasal mucosa (HP:0000433)3.23452167
24Atrial fibrillation (HP:0005110)3.16193965
25Distal lower limb muscle weakness (HP:0009053)3.07595668
26Type 1 muscle fiber predominance (HP:0003803)2.99154484
27Supraventricular arrhythmia (HP:0005115)2.95704416
28Muscle fiber inclusion bodies (HP:0100299)2.91589203
29Protrusio acetabuli (HP:0003179)2.90816959
30Primary atrial arrhythmia (HP:0001692)2.90177585
31Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.85055237
32Hypoglycemic coma (HP:0001325)2.84207798
33Conjunctival telangiectasia (HP:0000524)2.80930993
34Nemaline bodies (HP:0003798)2.79045124
35Lipoatrophy (HP:0100578)2.76534204
36Hemorrhage of the eye (HP:0011885)2.73680769
37Exercise-induced muscle cramps (HP:0003710)2.73458694
38Abnormality of complement system (HP:0005339)2.72948825
39Supraventricular tachycardia (HP:0004755)2.71579783
40Cavernous hemangioma (HP:0001048)2.66819479
41Hyperkalemia (HP:0002153)2.62969830
42Increased variability in muscle fiber diameter (HP:0003557)2.62423754
43Centrally nucleated skeletal muscle fibers (HP:0003687)2.61731359
44Aneurysm (HP:0002617)2.58849748
45Aortic dissection (HP:0002647)2.57997690
46Exercise-induced myalgia (HP:0003738)2.55078390
47Myoglobinuria (HP:0002913)2.54037332
48Growth hormone excess (HP:0000845)2.52576683
49Wrist flexion contracture (HP:0001239)2.51173601
50Syncope (HP:0001279)2.49797298
51Neck muscle weakness (HP:0000467)2.48259577
52Adactyly (HP:0009776)2.47913961
53Portal hypertension (HP:0001409)2.47750155
54Osteolytic defects of the hand bones (HP:0009699)2.46987818
55Osteolytic defects of the phalanges of the hand (HP:0009771)2.46987818
56Acanthosis nigricans (HP:0000956)2.45123751
57Calf muscle hypertrophy (HP:0008981)2.43960618
58Tetraparesis (HP:0002273)2.43583487
59Pulmonary artery stenosis (HP:0004415)2.43450126
60Striae distensae (HP:0001065)2.42766841
61Abnormality of the vasculature of the conjunctiva (HP:0008054)2.40115841
62Abnormality of skeletal muscle fiber size (HP:0012084)2.37776178
63Nonimmune hydrops fetalis (HP:0001790)2.26806031
64Aortic aneurysm (HP:0004942)2.26128479
65EMG: myopathic abnormalities (HP:0003458)2.25963435
66Prolonged QT interval (HP:0001657)2.25840174
67Mesangial abnormality (HP:0001966)2.24788267
68Tachypnea (HP:0002789)2.23393725
69Decreased circulating renin level (HP:0003351)2.22450997
70Distal lower limb amyotrophy (HP:0008944)2.21392044
71Systemic lupus erythematosus (HP:0002725)2.20661126
72Dilated cardiomyopathy (HP:0001644)2.19130703
73Muscle hypertrophy of the lower extremities (HP:0008968)2.18684988
74Atrioventricular block (HP:0001678)2.18572977
75Abnormality of the hepatic vasculature (HP:0006707)2.17217663
76Difficulty climbing stairs (HP:0003551)2.14287317
77Long toe (HP:0010511)2.12114110
78Glomerulonephritis (HP:0000099)2.12009346
79Facial shape deformation (HP:0011334)2.10753565
80Potter facies (HP:0002009)2.10753565
81Complement deficiency (HP:0004431)2.10612970
82Ketoacidosis (HP:0001993)2.10549798
83Pulmonary hypertension (HP:0002092)2.10036603
84Absent hand (HP:0004050)2.09746124
85Gout (HP:0001997)2.09400306
86Mucosal telangiectasiae (HP:0100579)2.09233760
87Rectal prolapse (HP:0002035)2.08396714
88Stroke (HP:0001297)2.07263121
89Neonatal death (HP:0003811)2.07025667
90Frequent falls (HP:0002359)2.05012328
91Skull defect (HP:0001362)2.04308681
92Hypoalphalipoproteinemia (HP:0003233)2.03999127
93Myocardial infarction (HP:0001658)2.03455491
94Premature rupture of membranes (HP:0001788)2.03273387
95Palpitations (HP:0001962)2.03236732
96Myotonia (HP:0002486)2.02922354
97Pigmentary retinal degeneration (HP:0001146)2.02834110
98Renal salt wasting (HP:0000127)2.02054957
99Porencephaly (HP:0002132)2.00566020
100Bundle branch block (HP:0011710)2.00253295
101Abnormality of the left ventricular outflow tract (HP:0011103)1.99339446
102Subaortic stenosis (HP:0001682)1.99339446
103Skin nodule (HP:0200036)1.99263014
104Hypokalemic alkalosis (HP:0001949)1.98983397
105Abnormality of the calf musculature (HP:0001430)1.98458346
106Mildly elevated creatine phosphokinase (HP:0008180)1.98299636
107Overgrowth (HP:0001548)1.97773672
108Respiratory distress (HP:0002098)1.96809226
109Heart block (HP:0012722)1.95123977
110Spinal rigidity (HP:0003306)1.94126008
111Asymmetric septal hypertrophy (HP:0001670)1.93330713
112Tubulointerstitial fibrosis (HP:0005576)1.93050280
113Venous abnormality (HP:0002624)1.91011407
114Axonal loss (HP:0003447)1.90774398
115Facial diplegia (HP:0001349)1.89841327
116Hypoplasia of the iris (HP:0007676)1.88487642
117Abnormal atrioventricular conduction (HP:0005150)1.86811925
118Reduced subcutaneous adipose tissue (HP:0003758)1.86181749
119Muscle stiffness (HP:0003552)1.84166101
120Nephritis (HP:0000123)1.83764695
121Venous insufficiency (HP:0005293)1.82820728
122Bone cyst (HP:0012062)1.82724995
123Joint hemorrhage (HP:0005261)1.82432190
124Shallow orbits (HP:0000586)1.81745914
125Abnormality of the fingertips (HP:0001211)1.81454006
126Distal arthrogryposis (HP:0005684)1.81383225
127Ventricular arrhythmia (HP:0004308)1.81284541
128Chondrocalcinosis (HP:0000934)1.78398130
129Rhabdomyolysis (HP:0003201)1.77432775
130Rapidly progressive (HP:0003678)1.77002420
131Abnormality of chloride homeostasis (HP:0011422)1.76748890
132Abnormality of fatty-acid metabolism (HP:0004359)1.76460817
133Short hallux (HP:0010109)1.74840369
134Hemiplegia (HP:0002301)1.74552267
135Hyperaldosteronism (HP:0000859)1.73255135

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE19.28792069
2KDR5.50924343
3TGFBR23.69480945
4RIPK12.78558779
5TTN2.14253026
6TRIB32.09440994
7EPHB21.98891239
8TGFBR11.92924347
9MYLK1.85735386
10PTK2B1.66561662
11FER1.62217023
12DMPK1.57060895
13FGFR21.55943109
14LATS21.49840424
15PDGFRA1.47237808
16EPHB11.45571363
17ERN11.45046851
18PDK21.44642130
19INSRR1.41601751
20LMTK21.40481918
21FGFR41.36436814
22FES1.30785152
23PTK61.30444654
24PKN21.27972603
25NTRK11.27340679
26CAMK1D1.26864702
27OBSCN1.22038096
28GRK11.21411319
29LRRK21.20900833
30PRKD11.14638913
31MAP2K31.12706439
32CAMK1G1.08604157
33FGFR31.06105677
34PHKG21.03884559
35PHKG11.03884559
36MAP3K61.03040103
37WNK41.03025305
38PAK41.01995309
39PRKG20.99708981
40SIK10.95776342
41PDK40.94987876
42PDK30.94987876
43MAP3K30.89654251
44LATS10.87822374
45BCKDK0.85925683
46PRKCH0.85841134
47EEF2K0.85252086
48PRKAA20.82369839
49PDGFRB0.81310199
50MAPK120.81236746
51ERBB40.81206323
52CSK0.80668744
53PRKD30.78635153
54PDPK10.78371540
55MOS0.76861015
56PTK20.73472434
57NLK0.73381374
58STK100.73298073
59STK380.70883217
60TESK10.70147121
61STK38L0.66515682
62MAP3K70.65546413
63GSK3A0.64767749
64ROCK20.64586571
65STK240.64522397
66MAP3K130.63237534
67FRK0.62438825
68RPS6KA20.62195531
69JAK10.58693687
70MET0.58619557
71RET0.58369141
72MAPK150.58280202
73SGK20.57647818
74ICK0.57578023
75PIK3CA0.54298935
76GRK50.53446449
77MAP3K10.52914791
78ILK0.52116896
79STK390.51304586
80PRPF4B0.51292287
81SGK2230.49208542
82SGK4940.49208542
83ROCK10.48333249
84MAP2K10.47671798
85AKT30.47551653
86DAPK20.46382680
87YES10.46218971
88EPHA30.45838790
89IGF1R0.45606234
90MARK20.43219885
91MAPK40.42705182
92EGFR0.42313186
93PAK30.41442871
94NEK90.41227577
95CAMK40.40985584
96LIMK10.39689568
97PRKAA10.38577558
98JAK20.38002344
99BCR0.37823897
100MAPK70.37714555
101PRKCE0.36919659
102SRC0.36788160
103NTRK30.36517404
104IRAK10.36470486
105WNK10.36440416
106PDK10.36381725
107ZAP700.33797054
108MAPKAPK30.33415171
109DDR20.33167813
110ABL20.32924421
111TEC0.32813716
112PRKD20.32371745
113SGK30.32228470
114PINK10.31804154
115MARK30.31242720
116TRPM70.30844427
117MAP2K20.30427785
118MAP3K20.29849415
119EPHA20.28783287
120PRKG10.28142923
121CDK60.27699036
122PAK20.27406892
123MTOR0.27391811
124MST1R0.26191459
125CAMK10.24003230
126INSR0.23602229
127KIT0.23450475
128CDC42BPA0.23060834
129KSR20.22649694

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid degradation_Homo sapiens_hsa000712.39521787
2ECM-receptor interaction_Homo sapiens_hsa045122.22994307
3Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.22901197
4PPAR signaling pathway_Homo sapiens_hsa033202.15450613
5Propanoate metabolism_Homo sapiens_hsa006402.13617254
6Dilated cardiomyopathy_Homo sapiens_hsa054142.02698048
7Nitrogen metabolism_Homo sapiens_hsa009101.98702712
8Focal adhesion_Homo sapiens_hsa045101.88658259
9Fatty acid metabolism_Homo sapiens_hsa012121.87346518
10Adherens junction_Homo sapiens_hsa045201.86620271
11Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.85455610
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.82436947
13Glycosaminoglycan degradation_Homo sapiens_hsa005311.81532411
14Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.75165635
152-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.75077135
16Caffeine metabolism_Homo sapiens_hsa002321.72715165
17Arginine biosynthesis_Homo sapiens_hsa002201.69722699
18Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.68737655
19Complement and coagulation cascades_Homo sapiens_hsa046101.57817549
20Tryptophan metabolism_Homo sapiens_hsa003801.51231771
21Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.49025035
22Leukocyte transendothelial migration_Homo sapiens_hsa046701.48818390
23Dorso-ventral axis formation_Homo sapiens_hsa043201.46820906
24Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.46556800
25Bile secretion_Homo sapiens_hsa049761.46524949
26Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.45231246
27Histidine metabolism_Homo sapiens_hsa003401.41128735
28Fatty acid biosynthesis_Homo sapiens_hsa000611.37385287
29Adipocytokine signaling pathway_Homo sapiens_hsa049201.28053257
30Pertussis_Homo sapiens_hsa051331.27532842
31AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.26654370
32Insulin resistance_Homo sapiens_hsa049311.25487177
33Circadian rhythm_Homo sapiens_hsa047101.18791807
34Rap1 signaling pathway_Homo sapiens_hsa040151.13542294
35Tight junction_Homo sapiens_hsa045301.12706932
36Renin secretion_Homo sapiens_hsa049241.12209424
37Amoebiasis_Homo sapiens_hsa051461.11482698
38Primary bile acid biosynthesis_Homo sapiens_hsa001201.08003568
39Vascular smooth muscle contraction_Homo sapiens_hsa042701.02995778
40Small cell lung cancer_Homo sapiens_hsa052221.02078717
41Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.00741379
42Platelet activation_Homo sapiens_hsa046110.94980580
43beta-Alanine metabolism_Homo sapiens_hsa004100.89154616
44Proteoglycans in cancer_Homo sapiens_hsa052050.87968351
45GnRH signaling pathway_Homo sapiens_hsa049120.87559787
46cGMP-PKG signaling pathway_Homo sapiens_hsa040220.87229176
47Renal cell carcinoma_Homo sapiens_hsa052110.86508621
48Butanoate metabolism_Homo sapiens_hsa006500.85968100
49Viral myocarditis_Homo sapiens_hsa054160.85760823
50Pyruvate metabolism_Homo sapiens_hsa006200.84518514
51Protein digestion and absorption_Homo sapiens_hsa049740.81653980
52ABC transporters_Homo sapiens_hsa020100.81234413
53Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.80710253
54VEGF signaling pathway_Homo sapiens_hsa043700.80642155
55Ovarian steroidogenesis_Homo sapiens_hsa049130.79999051
56Fat digestion and absorption_Homo sapiens_hsa049750.77246881
57AMPK signaling pathway_Homo sapiens_hsa041520.77200209
58PI3K-Akt signaling pathway_Homo sapiens_hsa041510.76262656
59Axon guidance_Homo sapiens_hsa043600.75370244
60Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.74688569
61Carbon metabolism_Homo sapiens_hsa012000.74389710
62Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.74115850
63Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.71964983
64Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.71940640
65Fatty acid elongation_Homo sapiens_hsa000620.71766571
66Gastric acid secretion_Homo sapiens_hsa049710.71621177
67Peroxisome_Homo sapiens_hsa041460.71269989
68Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.70819401
69Glycerolipid metabolism_Homo sapiens_hsa005610.70740973
70Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.67817149
71Notch signaling pathway_Homo sapiens_hsa043300.67654649
72Regulation of actin cytoskeleton_Homo sapiens_hsa048100.66948143
73HIF-1 signaling pathway_Homo sapiens_hsa040660.66344063
74Tyrosine metabolism_Homo sapiens_hsa003500.66197622
75Staphylococcus aureus infection_Homo sapiens_hsa051500.65784673
76Toxoplasmosis_Homo sapiens_hsa051450.65145250
77Malaria_Homo sapiens_hsa051440.64465996
78Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.64205243
79Cardiac muscle contraction_Homo sapiens_hsa042600.63907965
80Pancreatic cancer_Homo sapiens_hsa052120.63465836
81Lysine degradation_Homo sapiens_hsa003100.63164047
82Aldosterone synthesis and secretion_Homo sapiens_hsa049250.61346470
83Mineral absorption_Homo sapiens_hsa049780.59728451
84Calcium signaling pathway_Homo sapiens_hsa040200.58921103
85Glucagon signaling pathway_Homo sapiens_hsa049220.57453521
86Ras signaling pathway_Homo sapiens_hsa040140.57133187
87cAMP signaling pathway_Homo sapiens_hsa040240.56539127
88Choline metabolism in cancer_Homo sapiens_hsa052310.55245725
89Thyroid hormone synthesis_Homo sapiens_hsa049180.54530237
90MAPK signaling pathway_Homo sapiens_hsa040100.54369752
91Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.54351978
92Insulin signaling pathway_Homo sapiens_hsa049100.54235916
93Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.53985242
94Estrogen signaling pathway_Homo sapiens_hsa049150.53809785
95Starch and sucrose metabolism_Homo sapiens_hsa005000.53770178
96Phagosome_Homo sapiens_hsa041450.53455033
97Lysosome_Homo sapiens_hsa041420.52683734
98Gap junction_Homo sapiens_hsa045400.52682257
99Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.52071324
100Longevity regulating pathway - mammal_Homo sapiens_hsa042110.51146931
101Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.50053827
102Phospholipase D signaling pathway_Homo sapiens_hsa040720.49807130
103Salivary secretion_Homo sapiens_hsa049700.49503788
104Oxytocin signaling pathway_Homo sapiens_hsa049210.49320912
105Pathways in cancer_Homo sapiens_hsa052000.48304057
106Renin-angiotensin system_Homo sapiens_hsa046140.46089550
107African trypanosomiasis_Homo sapiens_hsa051430.45276633
108Phenylalanine metabolism_Homo sapiens_hsa003600.45136363
109Endocytosis_Homo sapiens_hsa041440.43811304
110Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.43772698
111Pancreatic secretion_Homo sapiens_hsa049720.43728367
112Long-term potentiation_Homo sapiens_hsa047200.43064147
113TGF-beta signaling pathway_Homo sapiens_hsa043500.42998401
114Serotonergic synapse_Homo sapiens_hsa047260.42883028
115Thyroid hormone signaling pathway_Homo sapiens_hsa049190.42267162
116FoxO signaling pathway_Homo sapiens_hsa040680.42105618
117Chronic myeloid leukemia_Homo sapiens_hsa052200.41841513
118Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.40421453
119Circadian entrainment_Homo sapiens_hsa047130.40301564
120Glioma_Homo sapiens_hsa052140.36698338
121Glycerophospholipid metabolism_Homo sapiens_hsa005640.36264917
122Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.35552688
123Arginine and proline metabolism_Homo sapiens_hsa003300.34943028
124Hippo signaling pathway_Homo sapiens_hsa043900.34314330
125Prion diseases_Homo sapiens_hsa050200.31803015
126Pentose and glucuronate interconversions_Homo sapiens_hsa000400.29744994

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