ADGRF4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Sequence analysis of this gene suggests that it is encodes a member of the superfamily of G protein-couple receptors. G protein-coupled receptors typically contain seven hydrophobic transmembrane domains, interact with guanine nucleotide binding regulatory proteins, and detect molecules outside the cell and act to transduce these signals into intracellular responses. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1keratinization (GO:0031424)9.53351844
2hemidesmosome assembly (GO:0031581)9.18894228
3molting cycle (GO:0042303)7.71933324
4hair cycle (GO:0042633)7.71933324
5multicellular organismal water homeostasis (GO:0050891)7.39886180
6keratinocyte differentiation (GO:0030216)7.14929884
7sphingoid metabolic process (GO:0046519)7.12082712
8keratinocyte proliferation (GO:0043616)6.66217510
9tooth mineralization (GO:0034505)6.54120535
10bundle of His cell to Purkinje myocyte communication (GO:0086069)6.47084072
11water homeostasis (GO:0030104)6.28373724
12sphingosine metabolic process (GO:0006670)5.82370911
13epidermal cell differentiation (GO:0009913)5.77986858
14intermediate filament organization (GO:0045109)5.75671329
15peptide cross-linking (GO:0018149)5.74379612
16long-chain fatty acid biosynthetic process (GO:0042759)5.73474958
17epidermis development (GO:0008544)5.57665554
18odontogenesis of dentin-containing tooth (GO:0042475)5.50940975
19diol metabolic process (GO:0034311)5.49728600
20surfactant homeostasis (GO:0043129)5.33090001
21gap junction assembly (GO:0016264)5.30773938
22regulation of ruffle assembly (GO:1900027)5.17627030
23regulation of keratinocyte proliferation (GO:0010837)5.15240971
24detection of bacterium (GO:0016045)4.97300937
25fatty acid elongation (GO:0030497)4.93985228
26positive regulation of epidermal cell differentiation (GO:0045606)4.68518467
27regulation of transforming growth factor beta2 production (GO:0032909)4.65482843
28skin morphogenesis (GO:0043589)4.54651939
29polarized epithelial cell differentiation (GO:0030859)4.53003545
30cell adhesion mediated by integrin (GO:0033627)4.51978506
31odontogenesis (GO:0042476)4.50995175
32dichotomous subdivision of an epithelial terminal unit (GO:0060600)4.50287756
33positive regulation of odontogenesis (GO:0042482)4.37215488
34regulation of cell proliferation involved in kidney development (GO:1901722)4.28322684
35glucosamine-containing compound catabolic process (GO:1901072)4.25577635
36regulation of phospholipase A2 activity (GO:0032429)4.23750241
37detection of other organism (GO:0098543)4.22890711
38negative regulation of cell fate specification (GO:0009996)4.16400088
39regulation of transforming growth factor beta1 production (GO:0032908)4.15277203
40positive regulation of keratinocyte differentiation (GO:0045618)4.09366351
41intestinal epithelial cell development (GO:0060576)4.04986696
42epithelial cell differentiation involved in prostate gland development (GO:0060742)3.92269021
43regulation of keratinocyte differentiation (GO:0045616)3.83152087
44keratinocyte development (GO:0003334)3.80667991
45regulation of epidermis development (GO:0045682)3.74599045
46hypotonic response (GO:0006971)3.69317060
47linoleic acid metabolic process (GO:0043651)3.68429812
48ectoderm development (GO:0007398)3.67989714
49interferon-gamma secretion (GO:0072643)3.63844360
50protein localization to endosome (GO:0036010)3.62410186
51positive regulation of interleukin-8 secretion (GO:2000484)3.62044448
52regulation of odontogenesis (GO:0042481)3.60206467
53regulation of hair cycle (GO:0042634)3.59887232
54negative regulation of stress fiber assembly (GO:0051497)3.59550514
55mesodermal cell differentiation (GO:0048333)3.51196585
56phospholipid scrambling (GO:0017121)3.45584572
57phosphatidylinositol acyl-chain remodeling (GO:0036149)3.44953766
58biomineral tissue development (GO:0031214)3.44815340
59epithelial cell-cell adhesion (GO:0090136)3.42538507
60intermediate filament cytoskeleton organization (GO:0045104)3.40632579
61endodermal cell differentiation (GO:0035987)3.35759186
62gland morphogenesis (GO:0022612)3.32239432
63skin development (GO:0043588)3.32079112
64intermediate filament-based process (GO:0045103)3.29464963
65cell junction assembly (GO:0034329)3.29362775
66negative regulation of kidney development (GO:0090185)3.28726487
67positive regulation of hair cycle (GO:0042635)3.28289467
68positive regulation of hair follicle development (GO:0051798)3.28289467
69regulation of odontogenesis of dentin-containing tooth (GO:0042487)3.27685867
70negative regulation of chondrocyte differentiation (GO:0032331)3.25596521
71long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.22167650
72cell junction organization (GO:0034330)3.21371806
73positive regulation of collagen biosynthetic process (GO:0032967)3.18435539
74regulation of chemokine secretion (GO:0090196)3.17950750
75cyclooxygenase pathway (GO:0019371)3.17147235
76chemical homeostasis within a tissue (GO:0048875)3.09965237
77negative regulation of cell fate commitment (GO:0010454)3.09586353
78plasma membrane repair (GO:0001778)3.09213915
79regulation of epidermal cell differentiation (GO:0045604)3.09187986
80phosphatidylserine acyl-chain remodeling (GO:0036150)3.05748110
81regulation of transforming growth factor beta production (GO:0071634)3.04680662
82positive regulation of collagen metabolic process (GO:0010714)3.04077516
83negative regulation of interferon-gamma production (GO:0032689)3.03729698
84regulation of cardioblast differentiation (GO:0051890)3.02558519
85virion attachment to host cell (GO:0019062)3.02537805
86adhesion of symbiont to host cell (GO:0044650)3.02537805
87morphogenesis of embryonic epithelium (GO:0016331)3.00949868
88lipoxygenase pathway (GO:0019372)3.00893229
89planar cell polarity pathway involved in neural tube closure (GO:0090179)2.99778971
90regulation of natural killer cell differentiation (GO:0032823)2.98564437
91negative regulation of epidermis development (GO:0045683)2.98484778
92establishment of tissue polarity (GO:0007164)2.95511911
93establishment of planar polarity (GO:0001736)2.95511911
94cell-substrate junction assembly (GO:0007044)2.94238686
95response to phenylpropanoid (GO:0080184)2.93040914
96regulation of glomerular filtration (GO:0003093)2.89860331
97cytoskeletal anchoring at plasma membrane (GO:0007016)2.89435696
98regulation of interleukin-8 secretion (GO:2000482)2.88879721
99regulation of heart rate by cardiac conduction (GO:0086091)2.86445275
100positive regulation of glomerulus development (GO:0090193)2.83845871
101focal adhesion assembly (GO:0048041)2.83736240
102cell-substrate adherens junction assembly (GO:0007045)2.83736240
103regulation of hypersensitivity (GO:0002883)2.82108109
104G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.81560074
105regulation of collagen biosynthetic process (GO:0032965)2.81068013
106regulation of metalloenzyme activity (GO:0048552)2.78004888
107phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.77231873
108epithelium development (GO:0060429)2.76254903
109regulation of hair follicle development (GO:0051797)2.76117159
110regulation of epidermal growth factor-activated receptor activity (GO:0007176)2.75529991
111sphingolipid biosynthetic process (GO:0030148)2.75136863
112positive regulation of Rho protein signal transduction (GO:0035025)2.74751183
113cell-cell junction assembly (GO:0007043)2.73514343
114viral transcription (GO:0019083)2.72903958
115negative regulation of stem cell proliferation (GO:2000647)2.72274682
116phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.71388548
117positive regulation of epidermis development (GO:0045684)2.67917764
118negative regulation of keratinocyte proliferation (GO:0010839)2.67710613
119fatty-acyl-CoA metabolic process (GO:0035337)2.67413388
120cardiac right ventricle morphogenesis (GO:0003215)2.67411749
121chemosensory behavior (GO:0007635)2.67388514
122regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.65511912
123mammary gland epithelial cell proliferation (GO:0033598)2.65375071
124atrioventricular valve morphogenesis (GO:0003181)2.65287015
125hair follicle morphogenesis (GO:0031069)2.64197310
126cell communication involved in cardiac conduction (GO:0086065)2.63593146
127endosome organization (GO:0007032)2.62433383
128L-serine transport (GO:0015825)2.62021479
129positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)2.60483623
130epithelial cell proliferation (GO:0050673)2.60443034
131negative regulation of actin filament bundle assembly (GO:0032232)2.60011570
132membrane raft organization (GO:0031579)2.59467375
133lateral sprouting from an epithelium (GO:0060601)2.57670170
134regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.57541453
135protein localization to microtubule (GO:0035372)2.56891411
136cell differentiation involved in embryonic placenta development (GO:0060706)2.56856491
137wound healing (GO:0042060)2.56232985
138regulation of cell fate specification (GO:0042659)2.55237370
139negative regulation of acute inflammatory response (GO:0002674)2.54937718
140regulation of protein localization to cell surface (GO:2000008)2.54855141
141negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.54716643
142ephrin receptor signaling pathway (GO:0048013)2.54180342
143eyelid development in camera-type eye (GO:0061029)2.53820901
144adherens junction organization (GO:0034332)2.53457180
145cellular component disassembly involved in execution phase of apoptosis (GO:0006921)2.53270922
146ventricular cardiac muscle cell action potential (GO:0086005)2.53135951
147natural killer cell mediated cytotoxicity (GO:0042267)2.52615467
148natural killer cell mediated immunity (GO:0002228)2.52615467
149translational termination (GO:0006415)2.51399564
150regulation of glomerulus development (GO:0090192)2.51179707
151regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.50760948
152COPI coating of Golgi vesicle (GO:0048205)2.49900662
153Golgi transport vesicle coating (GO:0048200)2.49900662
154renal filtration (GO:0097205)2.49144959
155hair cycle process (GO:0022405)2.47821114
156desmosome organization (GO:0002934)15.5162543
157establishment of skin barrier (GO:0061436)11.6803244
158regulation of water loss via skin (GO:0033561)10.8018364

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse6.37244698
2P63_26484246_Chip-Seq_KERATINOCYTES_Human2.66851094
3SOX9_24532713_ChIP-Seq_HFSC_Mouse2.66605687
4TRIM28_21343339_ChIP-Seq_HEK293_Human2.31476377
5ESR1_21235772_ChIP-Seq_MCF-7_Human2.24945674
6TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.21898895
7SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.16772058
8TP63_17297297_ChIP-ChIP_HaCaT_Human14.3133841
9ZNF263_19887448_ChIP-Seq_K562_Human1.87528280
10SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.85783253
11SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.85783253
12CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.83193810
13ESR2_21235772_ChIP-Seq_MCF-7_Human1.78342777
14ZNF217_24962896_ChIP-Seq_MCF-7_Human1.76817096
15CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.71048752
16FOXO3_23340844_ChIP-Seq_DLD1_Human1.64435738
17PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.60347686
18TCF4_18268006_ChIP-ChIP_LS174T_Human1.56682745
19TP63_23658742_ChIP-Seq_EP156T_Human1.47645495
20SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.47032226
21AR_21572438_ChIP-Seq_LNCaP_Human1.46608046
22SOX2_20726797_ChIP-Seq_SW620_Human1.43008852
23CJUN_26792858_Chip-Seq_BT549_Human1.37948576
24CLOCK_20551151_ChIP-Seq_293T_Human1.35762561
25TP53_18474530_ChIP-ChIP_U2OS_Human1.34599540
26TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.33271086
27RXR_22108803_ChIP-Seq_LS180_Human1.28621984
28AR_21909140_ChIP-Seq_LNCAP_Human1.26587197
29EZH2_27304074_Chip-Seq_ESCs_Mouse1.26279510
30AHR_22903824_ChIP-Seq_MCF-7_Human1.24760810
31SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.22225679
32BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.19023551
33KLF5_25053715_ChIP-Seq_YYC3_Human1.17621790
34SUZ12_27294783_Chip-Seq_ESCs_Mouse1.16808874
35P300_27058665_Chip-Seq_ZR-75-30cells_Human1.16625709
36EED_16625203_ChIP-ChIP_MESCs_Mouse1.16098798
37ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.16011282
38TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.15120446
39SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.14723365
40ARNT_22903824_ChIP-Seq_MCF-7_Human1.14605077
41HTT_18923047_ChIP-ChIP_STHdh_Human1.14270281
42RUNX1_27514584_Chip-Seq_MCF-7_Human1.11960404
43TP63_22573176_ChIP-Seq_HFKS_Human1.10478578
44HIF1A_21447827_ChIP-Seq_MCF-7_Human1.09980819
45GATA2_21666600_ChIP-Seq_HMVEC_Human1.09063381
46SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.08777668
47EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.07494742
48TP53_20018659_ChIP-ChIP_R1E_Mouse1.07411276
49JARID2_20075857_ChIP-Seq_MESCs_Mouse1.06952728
50SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.06597683
51ELK3_25401928_ChIP-Seq_HUVEC_Human1.06516048
52STAT6_21828071_ChIP-Seq_BEAS2B_Human1.05135266
53NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.03938641
54KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.03827082
55RNF2_18974828_ChIP-Seq_MESCs_Mouse1.03262228
56EZH2_18974828_ChIP-Seq_MESCs_Mouse1.03262228
57CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.02173817
58RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.01967420
59SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.01686148
60RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.01199392
61JARID2_20064375_ChIP-Seq_MESCs_Mouse1.00980456
62GATA4_25053715_ChIP-Seq_YYC3_Human0.98423983
63EZH2_27294783_Chip-Seq_ESCs_Mouse0.98190577
64RARG_19884340_ChIP-ChIP_MEFs_Mouse0.98121109
65GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.97910000
66GATA3_24758297_ChIP-Seq_MCF-7_Human0.97644199
67KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.97158016
68PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.96230186
69SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.95248404
70ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.94875147
71BCAT_22108803_ChIP-Seq_LS180_Human0.93879114
72HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.93732713
73KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.93603532
74BMI1_23680149_ChIP-Seq_NPCS_Mouse0.93466392
75RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.93037189
76ATF3_27146783_Chip-Seq_COLON_Human0.92258471
77RNF2_27304074_Chip-Seq_ESCs_Mouse0.92162598
78ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.91367815
79SMAD3_21741376_ChIP-Seq_HESCs_Human0.89885773
80TCF4_22108803_ChIP-Seq_LS180_Human0.89469814
81CDX2_20551321_ChIP-Seq_CACO-2_Human0.88148126
82TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.87234892
83RACK7_27058665_Chip-Seq_MCF-7_Human0.86852971
84PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.86448790
85CEBPB_22108803_ChIP-Seq_LS180_Human0.86186245
86ERG_21242973_ChIP-ChIP_JURKAT_Human0.84882035
87FOXM1_26456572_ChIP-Seq_MCF-7_Human0.84878116
88BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.84537097
89GATA6_21074721_ChIP-Seq_CACO-2_Human0.83803301
90TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.83379893
91MTF2_20144788_ChIP-Seq_MESCs_Mouse0.82346651
92FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.82172438
93UBF1/2_26484160_Chip-Seq_HMECs_Human0.80936744
94FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.80878898
95CDX2_19796622_ChIP-Seq_MESCs_Mouse0.80804807
96JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.80261523
97STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.80112634
98NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.79654727
99TBX20_22080862_ChIP-Seq_HEART_Mouse0.79599696
100TBX20_22328084_ChIP-Seq_HEART_Mouse0.79599696
101PPAR_26484153_Chip-Seq_NCI-H1993_Human0.79388462
102VDR_22108803_ChIP-Seq_LS180_Human0.77960345
103PIAS1_25552417_ChIP-Seq_VCAP_Human0.76330386
104ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.75797477
105TP53_16413492_ChIP-PET_HCT116_Human0.75779386
106ESR1_20079471_ChIP-ChIP_T-47D_Human0.74623384
107BRD4_25478319_ChIP-Seq_HGPS_Human0.74138233
108FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.74081717
109DNAJC2_21179169_ChIP-ChIP_NT2_Human0.73742254
110GATA6_25053715_ChIP-Seq_YYC3_Human0.73355145
111UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.73344164
112P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.72704451
113NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.72067097
114NRF2_20460467_ChIP-Seq_MEFs_Mouse0.72067097
115CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.71013076
116FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.69085666
117RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.68859989
118JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.68769490
119CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.68652009
120KLF4_18555785_ChIP-Seq_MESCs_Mouse0.68322144
121CTCF_27219007_Chip-Seq_Bcells_Human0.67398972
122EGR1_19032775_ChIP-ChIP_M12_Human0.67352052
123NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.66944557
124ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.66050684
125FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.65429455
126SOX2_27498859_Chip-Seq_STOMACH_Mouse0.64716415
127WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.64592096
128RBPJ_21746931_ChIP-Seq_IB4_Human0.63899356
129NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.63580290
130SRY_22984422_ChIP-ChIP_TESTIS_Rat0.62208783
131GATA1_22025678_ChIP-Seq_K562_Human0.62096118
132CHD1_26751641_Chip-Seq_LNCaP_Human0.61827559
133PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.61803847
134GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.61517266
135TP53_22127205_ChIP-Seq_IMR90_Human0.61083607
136EP300_21415370_ChIP-Seq_HL-1_Mouse0.59797560
137TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.57529829
138TET1_21490601_ChIP-Seq_MESCs_Mouse0.57400359
139PPARA_22158963_ChIP-Seq_LIVER_Mouse0.56139443
140TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.55327063
141ELF5_23300383_ChIP-Seq_T47D_Human0.54191652

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002796_impaired_skin_barrier7.98632733
2MP0005275_abnormal_skin_tensile5.80436444
3MP0003941_abnormal_skin_development5.40806520
4MP0010234_abnormal_vibrissa_follicle4.94620951
5MP0005501_abnormal_skin_physiology4.85251227
6MP0004381_abnormal_hair_follicle4.00133140
7MP0002060_abnormal_skin_morphology3.78688281
8MP0001216_abnormal_epidermal_layer3.49290897
9MP0010771_integument_phenotype3.28873756
10MP0002098_abnormal_vibrissa_morphology3.26473160
11MP0000579_abnormal_nail_morphology3.22390737
12MP0000383_abnormal_hair_follicle3.13310130
13MP0000647_abnormal_sebaceous_gland3.09709490
14MP0010678_abnormal_skin_adnexa3.07653495
15MP0002254_reproductive_system_inflammat3.02453282
16MP0003453_abnormal_keratinocyte_physiol2.97854038
17MP0005451_abnormal_body_composition2.67667849
18MP0000566_synostosis2.61142251
19MP0002009_preneoplasia2.57771374
20MP0000377_abnormal_hair_follicle2.56598379
21MP0000467_abnormal_esophagus_morphology2.27689737
22MP0004947_skin_inflammation2.19029337
23MP0000427_abnormal_hair_cycle2.02866936
24MP0000762_abnormal_tongue_morphology1.97049356
25MP0009931_abnormal_skin_appearance1.80370922
26MP0003566_abnormal_cell_adhesion1.73993917
27MP0002234_abnormal_pharynx_morphology1.66516771
28MP0003705_abnormal_hypodermis_morpholog1.66132771
29MP0001346_abnormal_lacrimal_gland1.65369171
30MP0004185_abnormal_adipocyte_glucose1.61074953
31MP0001191_abnormal_skin_condition1.58728827
32MP0001243_abnormal_dermal_layer1.41473742
33MP0000367_abnormal_coat/_hair1.41101041
34MP0009379_abnormal_foot_pigmentation1.36467699
35MP0003011_delayed_dark_adaptation1.28841684
36MP0001851_eye_inflammation1.28555287
37MP0008260_abnormal_autophagy1.19125505
38MP0009780_abnormal_chondrocyte_physiolo1.17476526
39MP0003315_abnormal_perineum_morphology1.15955350
40MP0000678_abnormal_parathyroid_gland1.08333290
41MP0001340_abnormal_eyelid_morphology1.06042639
42MP0005257_abnormal_intraocular_pressure0.99950267
43MP0000432_abnormal_head_morphology0.88584175
44MP0004272_abnormal_basement_membrane0.87262286
45MP0000538_abnormal_urinary_bladder0.78234287
46MP0005409_darkened_coat_color0.75393796
47MP0003136_yellow_coat_color0.74821522
48MP0005023_abnormal_wound_healing0.74345290
49MP0000537_abnormal_urethra_morphology0.74326318
50MP0001849_ear_inflammation0.72657779
51MP0004264_abnormal_extraembryonic_tissu0.71889373
52MP0003191_abnormal_cellular_cholesterol0.71528377
53MP0002006_tumorigenesis0.71349861
54MP0002166_altered_tumor_susceptibility0.71241117
55MP0009053_abnormal_anal_canal0.69280649
56MP0003935_abnormal_craniofacial_develop0.66911790
57MP0000858_altered_metastatic_potential0.66847985
58MP0001542_abnormal_bone_strength0.66601221
59MP0000627_abnormal_mammary_gland0.66575406
60MP0002177_abnormal_outer_ear0.65094680
61MP0000462_abnormal_digestive_system0.64681100
62MP0002089_abnormal_postnatal_growth/wei0.64203076
63MP0001984_abnormal_olfaction0.64063783
64MP0000613_abnormal_salivary_gland0.62085205
65MP0002249_abnormal_larynx_morphology0.61496174
66MP0002095_abnormal_skin_pigmentation0.61330077
67MP0010386_abnormal_urinary_bladder0.59118072
68MP0004782_abnormal_surfactant_physiolog0.58987882
69MP0003950_abnormal_plasma_membrane0.58710476
70MP0009384_cardiac_valve_regurgitation0.58506701
71MP0010030_abnormal_orbit_morphology0.57977537
72MP0008789_abnormal_olfactory_epithelium0.57635049
73MP0005187_abnormal_penis_morphology0.57360270
74MP0005394_taste/olfaction_phenotype0.57335021
75MP0005499_abnormal_olfactory_system0.57335021
76MP0010352_gastrointestinal_tract_polyps0.57125466
77MP0001784_abnormal_fluid_regulation0.57078036
78MP0008438_abnormal_cutaneous_collagen0.55927327
79MP0004885_abnormal_endolymph0.55237543
80MP0002877_abnormal_melanocyte_morpholog0.54461798
81MP0005508_abnormal_skeleton_morphology0.54145524
82MP0005197_abnormal_uvea_morphology0.53992288
83MP0008004_abnormal_stomach_pH0.53617929
84MP0005367_renal/urinary_system_phenotyp0.53563382
85MP0000516_abnormal_urinary_system0.53563382
86MP0002282_abnormal_trachea_morphology0.52464081
87MP0003091_abnormal_cell_migration0.51654510
88MP0005193_abnormal_anterior_eye0.51253307
89MP0000003_abnormal_adipose_tissue0.50840616
90MP0009250_abnormal_appendicular_skeleto0.49649829
91MP0006138_congestive_heart_failure0.48652598
92MP0000465_gastrointestinal_hemorrhage0.47342087
93MP0003755_abnormal_palate_morphology0.47040503
94MP0005076_abnormal_cell_differentiation0.45561466
95MP0001299_abnormal_eye_distance/0.44255367
96MP0002896_abnormal_bone_mineralization0.40997804
97MP0002697_abnormal_eye_size0.40465506
98MP0000750_abnormal_muscle_regeneration0.40388181
99MP0010368_abnormal_lymphatic_system0.40019959
100MP0004019_abnormal_vitamin_homeostasis0.39483474
101MP0005075_abnormal_melanosome_morpholog0.39318051
102MP0005621_abnormal_cell_physiology0.36557747
103MP0004197_abnormal_fetal_growth/weight/0.36535742
104MP0003329_amyloid_beta_deposits0.35291970
105MP0002086_abnormal_extraembryonic_tissu0.35095743
106MP0005360_urolithiasis0.34753680
107MP0001881_abnormal_mammary_gland0.34616122
108MP0006054_spinal_hemorrhage0.34409389
109MP0002111_abnormal_tail_morphology0.33213926
110MP0001958_emphysema0.33163548
111MP0000470_abnormal_stomach_morphology0.33091064
112MP0005666_abnormal_adipose_tissue0.32783701
113MP0003385_abnormal_body_wall0.32151144
114MP0003045_fibrosis0.32110590
115MP0005164_abnormal_response_to0.31830092
116MP0002233_abnormal_nose_morphology0.31686582
117MP0001765_abnormal_ion_homeostasis0.31602007
118MP0003806_abnormal_nucleotide_metabolis0.30836412
119MP0005083_abnormal_biliary_tract0.29695205
120MP0005375_adipose_tissue_phenotype0.29121738
121MP0003936_abnormal_reproductive_system0.28827881
122MP0001177_atelectasis0.27530987
123MP0002295_abnormal_pulmonary_circulatio0.27177371
124MP0002090_abnormal_vision0.26873176
125MP0003638_abnormal_response/metabolism_0.26432753
126MP0005248_abnormal_Harderian_gland0.24727334
127MP0005390_skeleton_phenotype0.23994537
128MP0002109_abnormal_limb_morphology0.22626158
129MP0003436_decreased_susceptibility_to0.22459332
130MP0003300_gastrointestinal_ulcer0.21752638
131MP0003763_abnormal_thymus_physiology0.21579770
132MP0002277_abnormal_respiratory_mucosa0.21441558

Predicted human phenotypes

RankGene SetZ-score
1Onycholysis (HP:0001806)8.17013795
2Hypotrichosis (HP:0001006)7.71201825
3Parakeratosis (HP:0001036)7.25093170
4Fragile nails (HP:0001808)6.96494996
5Plantar hyperkeratosis (HP:0007556)6.59465571
6Right ventricular cardiomyopathy (HP:0011663)6.50051966
7Congenital nonbullous ichthyosiform erythroderma (HP:0007479)6.47477093
8Congenital ichthyosiform erythroderma (HP:0007431)6.33530046
9Woolly hair (HP:0002224)6.13133691
10Milia (HP:0001056)5.56974034
11Palmoplantar hyperkeratosis (HP:0000972)5.39659994
12Increased IgE level (HP:0003212)5.34640913
13Erythema (HP:0010783)5.07852322
14Palmar hyperkeratosis (HP:0010765)5.05573393
15Abnormality of nail color (HP:0100643)4.99202804
16Lip pit (HP:0100267)4.93284384
17Atrophic scars (HP:0001075)4.70380489
18Erythroderma (HP:0001019)4.52742002
19Nail dystrophy (HP:0008404)4.01961367
20Abnormal blistering of the skin (HP:0008066)3.99763534
21Conjunctival hamartoma (HP:0100780)3.75141807
22Oral leukoplakia (HP:0002745)3.68254001
23Ectropion (HP:0000656)3.61333382
24Selective tooth agenesis (HP:0001592)3.57859792
25Sparse eyelashes (HP:0000653)3.53757587
26Pili torti (HP:0003777)3.52153029
27Natal tooth (HP:0000695)3.46617118
28Corneal erosion (HP:0200020)3.35490972
29Abnormality of secondary sexual hair (HP:0009888)3.33982589
30Abnormality of the axillary hair (HP:0100134)3.33982589
31Hypohidrosis (HP:0000966)3.25841060
32Oligodontia (HP:0000677)3.22511248
33Popliteal pterygium (HP:0009756)3.21904021
34Absent eyelashes (HP:0000561)3.16321151
35Advanced eruption of teeth (HP:0006288)3.14217814
36Hyporeflexia of lower limbs (HP:0002600)3.10589774
37Acanthosis nigricans (HP:0000956)3.06475992
38Gangrene (HP:0100758)3.06353728
39Thick nail (HP:0001805)3.02713772
40Ventricular tachycardia (HP:0004756)3.02075911
41Palmoplantar keratoderma (HP:0000982)2.95235859
42Sparse scalp hair (HP:0002209)2.93765995
43Ankyloglossia (HP:0010296)2.89699116
44Abnormality of placental membranes (HP:0011409)2.84628623
45Amniotic constriction ring (HP:0009775)2.84628623
46Pruritus (HP:0000989)2.83515231
47Hypoplasia of dental enamel (HP:0006297)2.81706133
48Hypoplastic labia majora (HP:0000059)2.75461507
49Curly hair (HP:0002212)2.73655312
50Alopecia of scalp (HP:0002293)2.64919712
51Distal lower limb muscle weakness (HP:0009053)2.48583479
52Abnormality of the labia majora (HP:0012881)2.48388760
53Hypodontia (HP:0000668)2.43886555
54Dehydration (HP:0001944)2.39748128
55Brittle hair (HP:0002299)2.39220138
56Ridged nail (HP:0001807)2.36863818
57Abnormality of oral frenula (HP:0000190)2.28433741
58Abnormality of the salivary glands (HP:0010286)2.28256523
59Concave nail (HP:0001598)2.23696964
60Ventricular fibrillation (HP:0001663)2.21947802
61Pterygium (HP:0001059)2.16670313
62Abnormality of dental color (HP:0011073)2.12035149
63Abnormality of the dental root (HP:0006486)2.11266359
64Taurodontia (HP:0000679)2.11266359
65Abnormality of permanent molar morphology (HP:0011071)2.11266359
66Septate vagina (HP:0001153)2.11135125
67Dry skin (HP:0000958)2.08557550
68Abnormal hair laboratory examination (HP:0003328)2.03078151
69Amelogenesis imperfecta (HP:0000705)11.5056283
70Aplasia cutis congenita (HP:0001057)1.99754189
71Hamartoma of the eye (HP:0010568)1.98639364
72Abnormality of the gastric mucosa (HP:0004295)1.98487322
73Abnormality of molar (HP:0011077)1.93641177
74Abnormality of molar morphology (HP:0011070)1.93641177
75Abnormality of the fingernails (HP:0001231)1.92868313
76Xerostomia (HP:0000217)1.92852443
77Lack of skin elasticity (HP:0100679)1.91219891
78Areflexia of lower limbs (HP:0002522)1.90777379
79Cheilitis (HP:0100825)1.90134118
80Fragile skin (HP:0001030)1.86431933
81Abnormality of the dental pulp (HP:0006479)1.84485280
82Nasolacrimal duct obstruction (HP:0000579)1.81319831
83Abnormal hemoglobin (HP:0011902)1.81216477
84Split foot (HP:0001839)1.81206570
85Labial hypoplasia (HP:0000066)1.80807791
86Corneal dystrophy (HP:0001131)1.80597877
87Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.79397016
88Laryngomalacia (HP:0001601)1.77483738
89Short nail (HP:0001799)1.74167763
90Absent eyebrow (HP:0002223)1.71967768
91Dry hair (HP:0011359)1.68676393
92Ulnar claw (HP:0001178)1.68124203
93Multifactorial inheritance (HP:0001426)1.68017025
94Congenital, generalized hypertrichosis (HP:0004540)1.66957202
95Trismus (HP:0000211)1.65387668
96Severe Myopia (HP:0011003)1.65011953
97Ureteral duplication (HP:0000073)1.64862857
98Skin pits (HP:0100276)1.63731093
99Hoarse voice (HP:0001609)1.62510947
100Hypoplastic female external genitalia (HP:0012815)1.61204848
101Breast hypoplasia (HP:0003187)1.61183120
102Hyperhidrosis (HP:0000975)1.59641016
103Hypergammaglobulinemia (HP:0010702)1.57700575
104Skin ulcer (HP:0200042)1.55905641
105Duplicated collecting system (HP:0000081)1.55657764
106Aplasia involving bones of the extremities (HP:0009825)1.55031392
107Aplasia involving bones of the upper limbs (HP:0009823)1.55031392
108Aplasia of the phalanges of the hand (HP:0009802)1.55031392
109Achilles tendon contracture (HP:0001771)1.53609394
110Malnutrition (HP:0004395)1.52775809
111Anonychia (HP:0001798)1.51007635
112Abnormality of the lacrimal duct (HP:0011481)1.50662167
113Anhidrosis (HP:0000970)1.50586523
114Neonatal death (HP:0003811)1.49670450
115Blepharitis (HP:0000498)1.49173592
116Vascular calcification (HP:0004934)1.48422238
117Intention tremor (HP:0002080)1.45287334
118Bifid scrotum (HP:0000048)1.43038536
119Sudden death (HP:0001699)1.41011343
120Abnormality of the Achilles tendon (HP:0005109)1.39103574
121Premature loss of primary teeth (HP:0006323)1.39056344
122Pustule (HP:0200039)1.37902809
123Carious teeth (HP:0000670)1.37058072
124Follicular hyperkeratosis (HP:0007502)1.36750924
125Absent hair (HP:0002298)1.35171836
126Conical tooth (HP:0000698)1.34324774
127Hypoplasia of the uterus (HP:0000013)1.31844086
128Malignant hyperthermia (HP:0002047)1.31034288
129Abnormality of the neuromuscular junction (HP:0003398)1.30210318
130Fatigable weakness (HP:0003473)1.30210318

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPKAPK35.26584629
2MST45.09943159
3FER4.39041277
4MAP3K34.14097504
5MST1R4.06051763
6TRPM73.36032194
7MAP3K22.71487828
8ARAF2.58906099
9EPHB22.42984876
10RPS6KB22.37918663
11BCR2.28007107
12TGFBR12.25169224
13LATS12.14207005
14CASK2.01950083
15PIM21.90364570
16NTRK11.81767211
17MAPKAPK51.79328691
18ERBB31.78885949
19PBK1.67788141
20LRRK21.67409836
21FGFR21.64974222
22CDK191.56229284
23EPHA41.48692200
24PAK41.41823024
25NME21.41222914
26FLT31.33988924
27MET1.31635748
28IRAK31.31399309
29CDK61.27304049
30TRIB31.25689552
31NTRK21.24349561
32GRK11.22193837
33DYRK1B1.21993121
34MAP3K71.18342638
35PIK3CG1.17725139
36EPHA31.13042623
37RIPK11.12539553
38ERN11.09880088
39STK38L1.07380872
40MAP3K91.04921972
41STK101.02190729
42MAP3K11.01452548
43TESK10.98927366
44PTK60.94814065
45EPHA20.94650551
46TAOK10.92208391
47SMG10.92139725
48FGFR10.90257120
49SCYL20.90083107
50STK240.89575923
51TNK20.87776084
52FGFR40.87520963
53RIPK40.86173609
54STK30.84429485
55KSR20.81617466
56PKN20.80530505
57FGFR30.80119750
58CDK120.73875018
59PRKD10.73730738
60PRKCE0.72790396
61MAP3K110.72415268
62MAP3K140.72211757
63CDK30.72095267
64SIK30.71840482
65PAK30.71429574
66BLK0.70684321
67LATS20.70334061
68OXSR10.69239253
69MAP2K60.68094233
70MOS0.68024529
71STK380.67698269
72ILK0.67366322
73MAPKAPK20.67323461
74NEK60.66788840
75RPS6KA20.65358440
76PDGFRB0.63548861
77PTK20.59006518
78BMX0.55960346
79KSR10.55277407
80PRKCI0.53981198
81BRAF0.53891877
82DYRK1A0.53429058
83MAP2K40.53100118
84MTOR0.52644813
85TGFBR20.52263338
86PKN10.51768070
87ERBB40.51085016
88TTN0.50060239
89TYRO30.49867433
90ITK0.49223939
91LIMK10.47625825
92EIF2AK30.47612709
93EEF2K0.46405838
94RAF10.45962824
95ABL20.45668123
96MAP3K130.44079050
97ADRBK10.43212000
98EPHB10.42635442
99STK110.41749178
100CSNK1D0.40468026
101YES10.39806156
102HIPK20.39712583
103MAPK120.39579124
104GSK3A0.39312699
105TYK20.39209017
106PDGFRA0.38920564
107MAP3K120.38650640
108PDK20.37928013
109RET0.37851837
110ROCK10.37551703
111MYLK0.37514626
112MAP2K10.35595048
113CSNK1A10.35593972
114CDK50.34952262
115IKBKB0.34730761
116PRPF4B0.34561724
117MAPK40.34468602
118MAP3K80.34399890
119MAPK70.34362410
120CAMK40.33749146
121BMPR20.33731019
122CAMK2G0.32914431
123PIK3CA0.32487618
124RPS6KB10.32134262
125SGK30.31105654
126CAMK10.30888631
127MARK20.29992336
128LMTK20.29775879
129EIF2AK20.29413354
130EIF2AK10.28968169
131ERBB20.28962705
132SRC0.28773403
133OBSCN0.28691011
134RPS6KA40.27393703
135MAP3K50.27107711
136PRKD20.26095252
137ABL10.25135241
138PRKCA0.24431039
139CAMK2A0.24243305
140WNK10.23889350
141SIK10.23740749
142NME10.23161972
143MAP3K60.22959729
144CSF1R0.22693648
145ROCK20.22625540
146RPS6KA10.21443905
147IGF1R0.21060701
148CHUK0.16841045
149MAP2K20.16664046
150RPS6KC10.16145878

Predicted pathways (KEGG)

RankGene SetZ-score
1Sphingolipid metabolism_Homo sapiens_hsa006003.52983598
2Cyanoamino acid metabolism_Homo sapiens_hsa004603.40303945
3Linoleic acid metabolism_Homo sapiens_hsa005912.94907951
4alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.86984714
5Arachidonic acid metabolism_Homo sapiens_hsa005902.45772504
6Fatty acid elongation_Homo sapiens_hsa000622.39835419
7Bacterial invasion of epithelial cells_Homo sapiens_hsa051002.38363635
8Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.31311583
9ECM-receptor interaction_Homo sapiens_hsa045122.16848765
10Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.04511296
11Ether lipid metabolism_Homo sapiens_hsa005651.86379459
12Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.80186018
13Phenylalanine metabolism_Homo sapiens_hsa003601.75527209
14Collecting duct acid secretion_Homo sapiens_hsa049661.73270686
15Ribosome_Homo sapiens_hsa030101.71020775
16Steroid biosynthesis_Homo sapiens_hsa001001.70641838
17Histidine metabolism_Homo sapiens_hsa003401.67047448
18Basal cell carcinoma_Homo sapiens_hsa052171.58329880
19Central carbon metabolism in cancer_Homo sapiens_hsa052301.54613915
20Tight junction_Homo sapiens_hsa045301.51414017
21Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.51131513
22Axon guidance_Homo sapiens_hsa043601.48584850
23Adherens junction_Homo sapiens_hsa045201.47703241
24Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.42879316
25Regulation of actin cytoskeleton_Homo sapiens_hsa048101.34831755
26Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.33382131
27Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.31961613
28GnRH signaling pathway_Homo sapiens_hsa049121.31316066
29Renal cell carcinoma_Homo sapiens_hsa052111.28086222
30Renin secretion_Homo sapiens_hsa049241.27386460
31Galactose metabolism_Homo sapiens_hsa000521.23830249
32Melanogenesis_Homo sapiens_hsa049161.21164169
33Amoebiasis_Homo sapiens_hsa051461.21145234
34VEGF signaling pathway_Homo sapiens_hsa043701.21131089
35Pancreatic cancer_Homo sapiens_hsa052121.19293216
36Retinol metabolism_Homo sapiens_hsa008301.18763151
37Pancreatic secretion_Homo sapiens_hsa049721.17460754
38Sphingolipid signaling pathway_Homo sapiens_hsa040711.17370909
39Hippo signaling pathway_Homo sapiens_hsa043901.14159172
40Proteoglycans in cancer_Homo sapiens_hsa052051.11826746
41Shigellosis_Homo sapiens_hsa051311.10945117
42Serotonergic synapse_Homo sapiens_hsa047261.09959277
43Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.09276387
44Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.09174421
45Chronic myeloid leukemia_Homo sapiens_hsa052201.08806226
46Vibrio cholerae infection_Homo sapiens_hsa051101.06555739
47Phototransduction_Homo sapiens_hsa047441.05942822
48Bladder cancer_Homo sapiens_hsa052191.05251393
49Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.03902130
50Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.03374470
51Gastric acid secretion_Homo sapiens_hsa049711.00733035
52Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.99590341
53Inositol phosphate metabolism_Homo sapiens_hsa005620.98771924
54Mineral absorption_Homo sapiens_hsa049780.98555069
55Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.97444102
56Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.95919628
57AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.95494699
58Long-term depression_Homo sapiens_hsa047300.94234647
59Long-term potentiation_Homo sapiens_hsa047200.94098995
60Notch signaling pathway_Homo sapiens_hsa043300.92840326
61Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.91510146
62Hedgehog signaling pathway_Homo sapiens_hsa043400.89966211
63Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.89320462
64Wnt signaling pathway_Homo sapiens_hsa043100.88490647
65Ras signaling pathway_Homo sapiens_hsa040140.88381067
66Dilated cardiomyopathy_Homo sapiens_hsa054140.88090399
67PI3K-Akt signaling pathway_Homo sapiens_hsa041510.87509731
68Salmonella infection_Homo sapiens_hsa051320.87501533
69Thyroid hormone signaling pathway_Homo sapiens_hsa049190.86835421
70Salivary secretion_Homo sapiens_hsa049700.86533209
71Leukocyte transendothelial migration_Homo sapiens_hsa046700.86399861
72Acute myeloid leukemia_Homo sapiens_hsa052210.85313854
73Toxoplasmosis_Homo sapiens_hsa051450.84572757
74Insulin signaling pathway_Homo sapiens_hsa049100.82399602
75Vascular smooth muscle contraction_Homo sapiens_hsa042700.81015376
76Sulfur metabolism_Homo sapiens_hsa009200.80902888
77Circadian rhythm_Homo sapiens_hsa047100.80555047
78Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.80338004
79Fructose and mannose metabolism_Homo sapiens_hsa000510.79172204
80Fat digestion and absorption_Homo sapiens_hsa049750.77660974
81Chemical carcinogenesis_Homo sapiens_hsa052040.76844338
82p53 signaling pathway_Homo sapiens_hsa041150.76820125
83TGF-beta signaling pathway_Homo sapiens_hsa043500.76735511
84MicroRNAs in cancer_Homo sapiens_hsa052060.76067915
85Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.75050098
86Small cell lung cancer_Homo sapiens_hsa052220.74850177
87ErbB signaling pathway_Homo sapiens_hsa040120.72838428
88Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.72658094
89Tyrosine metabolism_Homo sapiens_hsa003500.72528829
90Choline metabolism in cancer_Homo sapiens_hsa052310.69437523
91Fatty acid biosynthesis_Homo sapiens_hsa000610.68913292
92Synaptic vesicle cycle_Homo sapiens_hsa047210.68603651
93Phosphatidylinositol signaling system_Homo sapiens_hsa040700.68389858
94Non-small cell lung cancer_Homo sapiens_hsa052230.67240327
95Rap1 signaling pathway_Homo sapiens_hsa040150.67239590
96Hepatitis C_Homo sapiens_hsa051600.66510604
97Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.66310739
98Calcium signaling pathway_Homo sapiens_hsa040200.66189842
99Oxytocin signaling pathway_Homo sapiens_hsa049210.65681821
100Staphylococcus aureus infection_Homo sapiens_hsa051500.64780052
101Glioma_Homo sapiens_hsa052140.62497797
102Olfactory transduction_Homo sapiens_hsa047400.60600288
103Focal adhesion_Homo sapiens_hsa045100.59743859
104N-Glycan biosynthesis_Homo sapiens_hsa005100.59694984
105Thyroid cancer_Homo sapiens_hsa052160.58929706
106ABC transporters_Homo sapiens_hsa020100.58486859
107Estrogen signaling pathway_Homo sapiens_hsa049150.58411198
108Glutamatergic synapse_Homo sapiens_hsa047240.57148458
109Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.55629214
110Amphetamine addiction_Homo sapiens_hsa050310.55019036
111Dorso-ventral axis formation_Homo sapiens_hsa043200.55016848
112Melanoma_Homo sapiens_hsa052180.54791961
113Platelet activation_Homo sapiens_hsa046110.52826688
114Apoptosis_Homo sapiens_hsa042100.52714468
115Steroid hormone biosynthesis_Homo sapiens_hsa001400.52613568
116Glycerophospholipid metabolism_Homo sapiens_hsa005640.52213126
117Aldosterone synthesis and secretion_Homo sapiens_hsa049250.51275584
118Prion diseases_Homo sapiens_hsa050200.50955776
119Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.50898354
120Circadian entrainment_Homo sapiens_hsa047130.50187712
121Rheumatoid arthritis_Homo sapiens_hsa053230.49457441
122Ovarian steroidogenesis_Homo sapiens_hsa049130.48298525
123Pertussis_Homo sapiens_hsa051330.47565266
124Pentose phosphate pathway_Homo sapiens_hsa000300.46682370
125Phagosome_Homo sapiens_hsa041450.46424729
126Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.45365565
127Endometrial cancer_Homo sapiens_hsa052130.44927929
128Protein digestion and absorption_Homo sapiens_hsa049740.44349909
129Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.44127763
130Dopaminergic synapse_Homo sapiens_hsa047280.43272852
131Pathways in cancer_Homo sapiens_hsa052000.43195177
132Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.42284449
133Endocytosis_Homo sapiens_hsa041440.42129774
134Lysosome_Homo sapiens_hsa041420.41511296
135Gap junction_Homo sapiens_hsa045400.41339023
136Caffeine metabolism_Homo sapiens_hsa002320.41037400
137Neurotrophin signaling pathway_Homo sapiens_hsa047220.40904284
138Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.40775899
139Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.40278640
140cAMP signaling pathway_Homo sapiens_hsa040240.38328666
141Prostate cancer_Homo sapiens_hsa052150.37893018
142Starch and sucrose metabolism_Homo sapiens_hsa005000.35589983
143HIF-1 signaling pathway_Homo sapiens_hsa040660.34217210

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