ADGRF1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axonemal dynein complex assembly (GO:0070286)8.01708013
2cilium or flagellum-dependent cell motility (GO:0001539)7.66857349
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.36323606
4L-phenylalanine catabolic process (GO:0006559)7.36323606
5L-phenylalanine metabolic process (GO:0006558)7.02232250
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.02232250
7epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)6.78770796
8aromatic amino acid family catabolic process (GO:0009074)6.68746382
9cilium movement (GO:0003341)6.53027583
10diterpenoid biosynthetic process (GO:0016102)6.47283269
11indole-containing compound catabolic process (GO:0042436)6.28924711
12indolalkylamine catabolic process (GO:0046218)6.28924711
13tryptophan catabolic process (GO:0006569)6.28924711
14epithelial cilium movement (GO:0003351)6.23215961
15kynurenine metabolic process (GO:0070189)6.05974217
16tryptophan metabolic process (GO:0006568)5.95858270
17bile acid biosynthetic process (GO:0006699)5.84905831
18axoneme assembly (GO:0035082)5.83956706
19complement activation, alternative pathway (GO:0006957)5.83549477
20glyoxylate metabolic process (GO:0046487)5.68251483
21urea cycle (GO:0000050)5.63785769
22urea metabolic process (GO:0019627)5.63785769
23regulation of protein activation cascade (GO:2000257)5.60047344
24sulfur amino acid catabolic process (GO:0000098)5.49584733
25motile cilium assembly (GO:0044458)5.44740320
26regulation of complement activation (GO:0030449)5.33728807
27homocysteine metabolic process (GO:0050667)5.28243999
28triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.18863989
29alpha-linolenic acid metabolic process (GO:0036109)5.17111450
30nitrogen cycle metabolic process (GO:0071941)5.15287714
31high-density lipoprotein particle remodeling (GO:0034375)5.14814104
32cysteine metabolic process (GO:0006534)5.09582888
33protein carboxylation (GO:0018214)5.05970357
34peptidyl-glutamic acid carboxylation (GO:0017187)5.05970357
35negative regulation of fibrinolysis (GO:0051918)5.05881135
36terpenoid biosynthetic process (GO:0016114)5.05055949
37regulation of fibrinolysis (GO:0051917)4.97313345
38bile acid metabolic process (GO:0008206)4.87595752
39aromatic amino acid family metabolic process (GO:0009072)4.87301420
40fucose catabolic process (GO:0019317)4.83318372
41L-fucose metabolic process (GO:0042354)4.83318372
42L-fucose catabolic process (GO:0042355)4.83318372
43serine family amino acid catabolic process (GO:0009071)4.79869424
44tyrosine metabolic process (GO:0006570)4.68628547
45fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.67971362
46regulation of triglyceride catabolic process (GO:0010896)4.61840438
47regulation of cilium movement (GO:0003352)4.59516970
48lysine catabolic process (GO:0006554)4.53734612
49lysine metabolic process (GO:0006553)4.53734612
50coenzyme catabolic process (GO:0009109)4.53578905
51alpha-amino acid catabolic process (GO:1901606)4.52001105
52reverse cholesterol transport (GO:0043691)4.47502319
53indolalkylamine metabolic process (GO:0006586)4.42099294
54plasma lipoprotein particle remodeling (GO:0034369)4.41156430
55protein-lipid complex remodeling (GO:0034368)4.41156430
56macromolecular complex remodeling (GO:0034367)4.41156430
57amine catabolic process (GO:0009310)4.29571951
58cellular biogenic amine catabolic process (GO:0042402)4.29571951
59amino-acid betaine metabolic process (GO:0006577)4.28464286
60bile acid and bile salt transport (GO:0015721)4.27872677
61imidazole-containing compound metabolic process (GO:0052803)4.27427469
62cellular modified amino acid catabolic process (GO:0042219)4.24494539
63cellular amino acid catabolic process (GO:0009063)4.21742274
64retinoic acid metabolic process (GO:0042573)4.17468282
65calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)4.14818379
66triglyceride homeostasis (GO:0070328)4.11753784
67acylglycerol homeostasis (GO:0055090)4.11753784
68ethanol oxidation (GO:0006069)4.11615902
69negative regulation of sterol transport (GO:0032372)4.10805257
70negative regulation of cholesterol transport (GO:0032375)4.10805257
71glycine metabolic process (GO:0006544)4.08502740
72regulation of cholesterol esterification (GO:0010872)4.06551047
73benzene-containing compound metabolic process (GO:0042537)4.02953315
74glutamate metabolic process (GO:0006536)4.02426637
75cytolysis (GO:0019835)3.98262022
76cellular glucuronidation (GO:0052695)3.97042887
77cellular ketone body metabolic process (GO:0046950)3.95065767
78cilium organization (GO:0044782)3.90170927
79arginine metabolic process (GO:0006525)3.88456108
80cholesterol efflux (GO:0033344)3.88232514
81serine family amino acid metabolic process (GO:0009069)3.87492798
82one-carbon compound transport (GO:0019755)3.84757266
83fibrinolysis (GO:0042730)3.84324174
84plasma lipoprotein particle clearance (GO:0034381)3.81768943
85aldehyde catabolic process (GO:0046185)3.80186219
86complement activation, classical pathway (GO:0006958)3.79682305
87cofactor catabolic process (GO:0051187)3.78824165
88phospholipid homeostasis (GO:0055091)3.78722769
89complement activation (GO:0006956)3.78569204
90magnesium ion transport (GO:0015693)3.78470332
91cilium assembly (GO:0042384)3.76780609
92acetyl-CoA metabolic process (GO:0006084)3.73235369
93protein activation cascade (GO:0072376)3.72877795
94low-density lipoprotein particle remodeling (GO:0034374)3.71108807
95blood coagulation, intrinsic pathway (GO:0007597)3.70559886
96dicarboxylic acid biosynthetic process (GO:0043650)3.70478495
97phospholipid efflux (GO:0033700)3.70085283
98serine family amino acid biosynthetic process (GO:0009070)3.70046658
99left/right pattern formation (GO:0060972)3.67873688
100negative regulation of T cell differentiation in thymus (GO:0033085)3.66193788
101detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.65726822
102regulation of bile acid biosynthetic process (GO:0070857)3.62296965
103short-chain fatty acid metabolic process (GO:0046459)3.61863809
104organic acid catabolic process (GO:0016054)3.59089534
105carboxylic acid catabolic process (GO:0046395)3.59089534
106valine metabolic process (GO:0006573)3.58539310
107regulation of hippo signaling (GO:0035330)3.52666928
108cholesterol homeostasis (GO:0042632)3.51256487
109uronic acid metabolic process (GO:0006063)3.50735952
110glucuronate metabolic process (GO:0019585)3.50735952
111negative regulation of protein activation cascade (GO:2000258)3.50396790
112drug catabolic process (GO:0042737)3.50173275
113platelet dense granule organization (GO:0060155)3.47861446
114sterol homeostasis (GO:0055092)3.47806672
115drug transmembrane transport (GO:0006855)3.47148048
116retinol metabolic process (GO:0042572)3.46760336
117disruption of cells of other organism (GO:0044364)3.46623252
118killing of cells of other organism (GO:0031640)3.46623252
119plasma lipoprotein particle assembly (GO:0034377)3.46568379
120urate metabolic process (GO:0046415)3.46231418
121photoreceptor cell maintenance (GO:0045494)3.45886051
1222-oxoglutarate metabolic process (GO:0006103)3.44935941
123ketone body metabolic process (GO:1902224)3.44278033
124behavioral response to nicotine (GO:0035095)3.43125185
125positive regulation of lipid catabolic process (GO:0050996)3.40843582
126left/right axis specification (GO:0070986)3.40495344
127regulation of cholesterol homeostasis (GO:2000188)3.39678632
128cornea development in camera-type eye (GO:0061303)3.38829789
129thyroid hormone metabolic process (GO:0042403)3.38207079
130primary alcohol catabolic process (GO:0034310)3.37671751
131positive regulation of lipoprotein lipase activity (GO:0051006)3.36671668
132detection of light stimulus involved in sensory perception (GO:0050962)3.33367687
133detection of light stimulus involved in visual perception (GO:0050908)3.33367687
134exogenous drug catabolic process (GO:0042738)3.30463346
135thyroid hormone generation (GO:0006590)3.29272110
136retinal metabolic process (GO:0042574)3.24654508
137intraciliary transport (GO:0042073)3.24162459
138nephron tubule formation (GO:0072079)3.24044218
139cilium morphogenesis (GO:0060271)3.23681371
140neural tube formation (GO:0001841)3.21201450
141regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033393.16446622
142sphingoid metabolic process (GO:0046519)3.12202079
143iron coordination entity transport (GO:1901678)3.08301663
144response to xenobiotic stimulus (GO:0009410)3.06646010
145positive regulation of vesicle fusion (GO:0031340)3.06049770
146nonmotile primary cilium assembly (GO:0035058)3.04318726
147negative regulation of mesenchymal cell apoptotic process (GO:2001054)3.04140020
148excretion (GO:0007588)3.02216515
149fucosylation (GO:0036065)2.99459043
150microtubule bundle formation (GO:0001578)2.91597195
151cellular component assembly involved in morphogenesis (GO:0010927)2.86284887
152response to pheromone (GO:0019236)2.84706842
153reflex (GO:0060004)2.82853219
154regulation of microtubule-based movement (GO:0060632)2.80373306
155protein K11-linked deubiquitination (GO:0035871)2.79773117
156protein localization to cilium (GO:0061512)2.79321327
157vitamin transmembrane transport (GO:0035461)2.79234047
158preassembly of GPI anchor in ER membrane (GO:0016254)2.74404581
159multicellular organism reproduction (GO:0032504)2.71859163
160rRNA catabolic process (GO:0016075)2.71616255
161O-glycan processing (GO:0016266)2.68922154
162behavioral response to ethanol (GO:0048149)2.65794702
163response to nitrosative stress (GO:0051409)2.65143040
164piRNA metabolic process (GO:0034587)2.64881971
165embryonic epithelial tube formation (GO:0001838)2.64427864
166arginine catabolic process (GO:0006527)2.62773211
167cell projection assembly (GO:0030031)2.61800713
168flavonoid metabolic process (GO:0009812)2.60100597
169lung epithelium development (GO:0060428)2.58416095
170glutathione derivative metabolic process (GO:1901685)2.56564435
171glutathione derivative biosynthetic process (GO:1901687)2.56564435
172endoderm formation (GO:0001706)2.54410550
173pyrimidine-containing compound transmembrane transport (GO:0072531)2.52402016
174regulation of mesenchymal cell apoptotic process (GO:2001053)2.50336834
175parturition (GO:0007567)2.49452630
176intestinal epithelial cell development (GO:0060576)2.49393669
177indole-containing compound metabolic process (GO:0042430)2.48646138
178regulation of gene silencing by miRNA (GO:0060964)2.42102443
179regulation of gene silencing by RNA (GO:0060966)2.42102443
180regulation of posttranscriptional gene silencing (GO:0060147)2.42102443
181transepithelial transport (GO:0070633)2.41900900
182diol metabolic process (GO:0034311)2.40188451
183epithelial tube formation (GO:0072175)2.40076533
184regulation of memory T cell differentiation (GO:0043380)2.37543327
185sperm motility (GO:0030317)2.36126488
186keratinocyte proliferation (GO:0043616)2.35142961
187respiratory chain complex IV assembly (GO:0008535)2.33593463
188anterograde synaptic vesicle transport (GO:0048490)2.32811017
189keratinocyte development (GO:0003334)2.32669568
190sulfation (GO:0051923)2.32277900

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse7.64670837
2EGR1_23403033_ChIP-Seq_LIVER_Mouse6.64076588
3PPARA_22158963_ChIP-Seq_LIVER_Mouse6.63309397
4LXR_22158963_ChIP-Seq_LIVER_Mouse6.11039979
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.79981585
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.45381369
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.28441918
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.93411277
9VDR_22108803_ChIP-Seq_LS180_Human3.65724805
10CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.34131796
11ZNF274_21170338_ChIP-Seq_K562_Hela3.17068351
12GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.50637195
13GBX2_23144817_ChIP-Seq_PC3_Human2.44223777
14ZFP57_27257070_Chip-Seq_ESCs_Mouse2.13158603
15HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.08344262
16STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.02164010
17TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.02092535
18ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.0751465
19ER_23166858_ChIP-Seq_MCF-7_Human1.94499154
20AHR_22903824_ChIP-Seq_MCF-7_Human1.90544030
21FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.88235533
22NR3C1_21868756_ChIP-Seq_MCF10A_Human1.79529201
23ARNT_22903824_ChIP-Seq_MCF-7_Human1.78393174
24CTBP2_25329375_ChIP-Seq_LNCAP_Human1.78083248
25POU3F2_20337985_ChIP-ChIP_501MEL_Human1.76494003
26TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.74476877
27EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.73841763
28AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.72730125
29FOXA2_19822575_ChIP-Seq_HepG2_Human1.71290920
30GATA1_22025678_ChIP-Seq_K562_Human1.67538876
31CTBP1_25329375_ChIP-Seq_LNCAP_Human1.66253441
32CLOCK_20551151_ChIP-Seq_293T_Human1.62932313
33RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.61773259
34SOX2_27498859_Chip-Seq_STOMACH_Mouse1.59185813
35STAT3_23295773_ChIP-Seq_U87_Human1.58793553
36TP53_16413492_ChIP-PET_HCT116_Human1.56080521
37TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.52646922
38P300_19829295_ChIP-Seq_ESCs_Human1.52576976
39STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.51325587
40TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.51060104
41FOXA1_25329375_ChIP-Seq_VCAP_Human1.50738980
42FOXA1_27270436_Chip-Seq_PROSTATE_Human1.50738980
43TCF4_22108803_ChIP-Seq_LS180_Human1.48646712
44HNF4A_19822575_ChIP-Seq_HepG2_Human1.46816168
45FLI1_27457419_Chip-Seq_LIVER_Mouse1.46005230
46HTT_18923047_ChIP-ChIP_STHdh_Human1.45220913
47TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.43433087
48TCF4_23295773_ChIP-Seq_U87_Human1.43061144
49CJUN_26792858_Chip-Seq_BT549_Human1.40723646
50AR_25329375_ChIP-Seq_VCAP_Human1.40709700
51CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.39250123
52PCGF2_27294783_Chip-Seq_ESCs_Mouse1.36615486
53TP63_23658742_ChIP-Seq_EP156T_Human1.36520915
54FOXA1_21572438_ChIP-Seq_LNCaP_Human1.36491919
55HOXB7_26014856_ChIP-Seq_BT474_Human1.34843782
56FUS_26573619_Chip-Seq_HEK293_Human1.32938675
57RARG_19884340_ChIP-ChIP_MEFs_Mouse1.32713616
58SMAD4_21799915_ChIP-Seq_A2780_Human1.32336582
59IRF1_19129219_ChIP-ChIP_H3396_Human1.32182333
60IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.29215611
61CBP_20019798_ChIP-Seq_JUKART_Human1.29215611
62EWS_26573619_Chip-Seq_HEK293_Human1.28799022
63PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.28033674
64EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.27192808
65GATA4_25053715_ChIP-Seq_YYC3_Human1.26888995
66SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.24976502
67ESR1_15608294_ChIP-ChIP_MCF-7_Human1.23360174
68ESR2_21235772_ChIP-Seq_MCF-7_Human1.22572505
69SMAD4_21741376_ChIP-Seq_EPCs_Human1.22314323
70SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.21468298
71PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.20419883
72ESR1_21235772_ChIP-Seq_MCF-7_Human1.20164092
73SOX2_19829295_ChIP-Seq_ESCs_Human1.17546508
74NANOG_19829295_ChIP-Seq_ESCs_Human1.17546508
75ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.17528795
76PRDM14_20953172_ChIP-Seq_ESCs_Human1.16726045
77GATA3_21878914_ChIP-Seq_MCF-7_Human1.15702041
78TOP2B_26459242_ChIP-Seq_MCF-7_Human1.15095612
79JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.14846921
80NCOR_22424771_ChIP-Seq_293T_Human1.13939864
81MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.13345779
82DROSHA_22980978_ChIP-Seq_HELA_Human1.12877660
83BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.12666673
84TP63_17297297_ChIP-ChIP_HaCaT_Human1.12656148
85CDX2_20551321_ChIP-Seq_CACO-2_Human1.12354699
86UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.11884488
87AR_21572438_ChIP-Seq_LNCaP_Human1.11715511
88SALL1_21062744_ChIP-ChIP_HESCs_Human1.11552202
89SMAD3_21741376_ChIP-Seq_EPCs_Human1.10650502
90ZNF263_19887448_ChIP-Seq_K562_Human1.10059961
91SMAD3_21741376_ChIP-Seq_HESCs_Human1.09635208
92AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.09460546
93SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.08737742
94TP53_18474530_ChIP-ChIP_U2OS_Human1.07487744
95RXRA_24833708_ChIP-Seq_LIVER_Mouse1.06158142
96IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.06105975
97SOX2_20726797_ChIP-Seq_SW620_Human1.05569902
98RUNX2_22187159_ChIP-Seq_PCA_Human1.05555333
99KLF5_20875108_ChIP-Seq_MESCs_Mouse1.05256355
100RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.04864905
101PCGF2_27294783_Chip-Seq_NPCs_Mouse1.04709007
102CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.03506044
103STAT1_20625510_ChIP-Seq_HELA_Human1.02161693
104FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.99544609
105Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.97827065
106TP53_22573176_ChIP-Seq_HFKS_Human0.97720717
107GATA3_26560356_Chip-Seq_TH2_Human0.96967888
108ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.96647969
109RXR_22108803_ChIP-Seq_LS180_Human0.96613063
110SALL4_18804426_ChIP-ChIP_XEN_Mouse0.95777370
111ESR1_20079471_ChIP-ChIP_T-47D_Human0.93405801
112FOXA1_25552417_ChIP-Seq_VCAP_Human0.87044236
113BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.86826425
114NRF2_20460467_ChIP-Seq_MEFs_Mouse0.86272991
115NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.86272991
116IRF8_22096565_ChIP-ChIP_GC-B_Human0.85656260
117CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.84532709
118FOXO3_23340844_ChIP-Seq_DLD1_Human0.83731897
119FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.83318517
120GATA6_25053715_ChIP-Seq_YYC3_Human0.80634145
121PPAR_26484153_Chip-Seq_NCI-H1993_Human0.79642223
122THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.78300453
123PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.76789772
124ZNF217_24962896_ChIP-Seq_MCF-7_Human0.75825815
125FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.74593349
126AUTS2_25519132_ChIP-Seq_293T-REX_Human0.73773924
127BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.71119915
128CDX2_19796622_ChIP-Seq_MESCs_Mouse0.70997214
129ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.68102559
130PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.67931837
131ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.66804637
132NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.66218438
133GATA3_24758297_ChIP-Seq_MCF-7_Human0.65546094
134RARA_24833708_ChIP-Seq_LIVER_Mouse0.64938733
135FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.64880784
136AR_20517297_ChIP-Seq_VCAP_Human0.64272487
137CDX2_22108803_ChIP-Seq_LS180_Human0.63600844
138KAP1_22055183_ChIP-Seq_ESCs_Mouse0.63552647
139PIAS1_25552417_ChIP-Seq_VCAP_Human0.63512299
140GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.61837068
141ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.60773554
142FOXM1_26456572_ChIP-Seq_MCF-7_Human0.60330221
143SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.58159898
144STAT3_1855785_ChIP-Seq_MESCs_Mouse0.57735837
145CEBPB_22108803_ChIP-Seq_LS180_Human0.57458208
146RAD21_21589869_ChIP-Seq_MESCs_Mouse0.56752233
147GATA2_21666600_ChIP-Seq_HMVEC_Human0.55728516
148STAT1_17558387_ChIP-Seq_HELA_Human0.54118343
149NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.53425946
150CBP_21632823_ChIP-Seq_H3396_Human0.53364832
151GATA2_19941826_ChIP-Seq_K562_Human0.53319156
152ERG_20517297_ChIP-Seq_VCAP_Human0.53159853
153P53_21459846_ChIP-Seq_SAOS-2_Human0.52426690
154EGR1_19032775_ChIP-ChIP_M12_Human0.51870934
155RARB_24833708_ChIP-Seq_LIVER_Mouse0.50857589
156CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.49600452
157ESET_19884257_ChIP-Seq_ESCs_Mouse0.49562267
158MYC_19915707_ChIP-ChIP_AK7_Human0.48979137
159ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.48553857
160TAF15_26573619_Chip-Seq_HEK293_Human0.47781687
161BCAT_22108803_ChIP-Seq_LS180_Human0.47323857
162PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.47315529
163TRIM28_21343339_ChIP-Seq_HEK293_Human0.47198061
164SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.47117967
165TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.46400711
166MYC_27129775_Chip-Seq_CORNEA_Mouse0.45399887
167CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.45117119
168PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.43885973

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.77859404
2MP0005360_urolithiasis7.28243593
3MP0005085_abnormal_gallbladder_physiolo6.26726920
4MP0005365_abnormal_bile_salt5.65694504
5MP0008875_abnormal_xenobiotic_pharmacok4.57894083
6MP0003252_abnormal_bile_duct3.81778595
7MP0003806_abnormal_nucleotide_metabolis3.58831763
8MP0010329_abnormal_lipoprotein_level3.21967888
9MP0001501_abnormal_sleep_pattern2.88223413
10MP0005083_abnormal_biliary_tract2.82656463
11MP0005332_abnormal_amino_acid2.80590711
12MP0000383_abnormal_hair_follicle2.77836433
13MP0009840_abnormal_foam_cell2.65819777
14MP0001666_abnormal_nutrient_absorption2.60864973
15MP0003195_calcinosis2.55414406
16MP0003950_abnormal_plasma_membrane2.45511325
17MP0010678_abnormal_skin_adnexa2.43758760
18MP0004019_abnormal_vitamin_homeostasis2.25940761
19MP0005645_abnormal_hypothalamus_physiol2.24102211
20MP0002138_abnormal_hepatobiliary_system2.08524449
21MP0000427_abnormal_hair_cycle2.04196585
22MP0000609_abnormal_liver_physiology2.03429746
23MP0003191_abnormal_cellular_cholesterol1.96881635
24MP0005551_abnormal_eye_electrophysiolog1.92427957
25MP0002909_abnormal_adrenal_gland1.92284400
26MP0002118_abnormal_lipid_homeostasis1.90171916
27MP0000569_abnormal_digit_pigmentation1.84873364
28MP0010386_abnormal_urinary_bladder1.84268356
29MP0003868_abnormal_feces_composition1.83934516
30MP0002160_abnormal_reproductive_system1.82236142
31MP0005319_abnormal_enzyme/_coenzyme1.78195209
32MP0000566_synostosis1.77944259
33MP0003646_muscle_fatigue1.75803704
34MP0008789_abnormal_olfactory_epithelium1.73796455
35MP0003011_delayed_dark_adaptation1.69917266
36MP0004133_heterotaxia1.67290450
37MP0001764_abnormal_homeostasis1.64145759
38MP0002653_abnormal_ependyma_morphology1.62970707
39MP0005646_abnormal_pituitary_gland1.60331061
40MP0005584_abnormal_enzyme/coenzyme_acti1.55364353
41MP0003300_gastrointestinal_ulcer1.55239499
42MP0009643_abnormal_urine_homeostasis1.53112002
43MP0005647_abnormal_sex_gland1.49701966
44MP0005220_abnormal_exocrine_pancreas1.46901483
45MP0000467_abnormal_esophagus_morphology1.44065643
46MP0002234_abnormal_pharynx_morphology1.42109533
47MP0003656_abnormal_erythrocyte_physiolo1.40366382
48MP0002102_abnormal_ear_morphology1.40314872
49MP0006292_abnormal_olfactory_placode1.37818492
50MP0009697_abnormal_copulation1.36550021
51MP0003943_abnormal_hepatobiliary_system1.35451055
52MP0003186_abnormal_redox_activity1.34005091
53MP0001984_abnormal_olfaction1.32825065
54MP0002168_other_aberrant_phenotype1.32596307
55MP0005389_reproductive_system_phenotype1.31969047
56MP0009780_abnormal_chondrocyte_physiolo1.27161093
57MP0001664_abnormal_digestion1.25512089
58MP0005253_abnormal_eye_physiology1.25357076
59MP0002876_abnormal_thyroid_physiology1.23965968
60MP0001485_abnormal_pinna_reflex1.22850558
61MP0005636_abnormal_mineral_homeostasis1.22828793
62MP0001873_stomach_inflammation1.22221895
63MP0010234_abnormal_vibrissa_follicle1.19274639
64MP0005408_hypopigmentation1.18269983
65MP0002254_reproductive_system_inflammat1.17903258
66MP0009764_decreased_sensitivity_to1.17680346
67MP0003045_fibrosis1.15940725
68MP0002277_abnormal_respiratory_mucosa1.14702563
69MP0002163_abnormal_gland_morphology1.13418173
70MP0000598_abnormal_liver_morphology1.10299407
71MP0000681_abnormal_thyroid_gland1.06842716
72MP0003705_abnormal_hypodermis_morpholog1.05428780
73MP0002282_abnormal_trachea_morphology1.03574964
74MP0002098_abnormal_vibrissa_morphology1.03224997
75MP0009046_muscle_twitch1.01905691
76MP0000631_abnormal_neuroendocrine_gland1.01681700
77MP0006072_abnormal_retinal_apoptosis1.01675195
78MP0001968_abnormal_touch/_nociception1.00846580
79MP0001881_abnormal_mammary_gland1.00683614
80MP0000604_amyloidosis0.99370707
81MP0005377_hearing/vestibular/ear_phenot0.99350677
82MP0003878_abnormal_ear_physiology0.99350677
83MP0002733_abnormal_thermal_nociception0.97723793
84MP0002638_abnormal_pupillary_reflex0.95923817
85MP0009763_increased_sensitivity_to0.95256592
86MP0008775_abnormal_heart_ventricle0.93649415
87MP0004084_abnormal_cardiac_muscle0.91968203
88MP0005451_abnormal_body_composition0.91666981
89MP0002132_abnormal_respiratory_system0.91586495
90MP0010368_abnormal_lymphatic_system0.89317253
91MP0008469_abnormal_protein_level0.88242772
92MP0005164_abnormal_response_to0.87667549
93MP0005379_endocrine/exocrine_gland_phen0.87294504
94MP0000013_abnormal_adipose_tissue0.86947664
95MP0000647_abnormal_sebaceous_gland0.86845876
96MP0009379_abnormal_foot_pigmentation0.86832023
97MP0005195_abnormal_posterior_eye0.86634880
98MP0000470_abnormal_stomach_morphology0.86127795
99MP0004215_abnormal_myocardial_fiber0.85484384
100MP0001756_abnormal_urination0.85306734
101MP0001502_abnormal_circadian_rhythm0.84561950
102MP0002736_abnormal_nociception_after0.84459199
103MP0000613_abnormal_salivary_gland0.83940119
104MP0001970_abnormal_pain_threshold0.83157646
105MP0009745_abnormal_behavioral_response0.81623669
106MP0009642_abnormal_blood_homeostasis0.80676938
107MP0004264_abnormal_extraembryonic_tissu0.79251044
108MP0002166_altered_tumor_susceptibility0.79098327
109MP0005499_abnormal_olfactory_system0.77385996
110MP0005394_taste/olfaction_phenotype0.77385996
111MP0002693_abnormal_pancreas_physiology0.75840225
112MP0005167_abnormal_blood-brain_barrier0.72530786
113MP0000462_abnormal_digestive_system0.72448717
114MP0009765_abnormal_xenobiotic_induced0.72185689
115MP0002136_abnormal_kidney_physiology0.71134225
116MP0000371_diluted_coat_color0.70482689
117MP0003936_abnormal_reproductive_system0.70288228
118MP0005166_decreased_susceptibility_to0.69363666
119MP0005376_homeostasis/metabolism_phenot0.68720638
120MP0001324_abnormal_eye_pigmentation0.68702810
121MP0000372_irregular_coat_pigmentation0.68583030
122MP0009384_cardiac_valve_regurgitation0.67383580
123MP0004885_abnormal_endolymph0.66984347
124MP0003953_abnormal_hormone_level0.64176511
125MP0005334_abnormal_fat_pad0.64129693
126MP0004130_abnormal_muscle_cell0.64127664
127MP0001765_abnormal_ion_homeostasis0.64060777
128MP0002078_abnormal_glucose_homeostasis0.63765834
129MP0008872_abnormal_physiological_respon0.63730302
130MP0005084_abnormal_gallbladder_morpholo0.63094524
131MP0003698_abnormal_male_reproductive0.63036500
132MP0003866_abnormal_defecation0.62833571
133MP0001986_abnormal_taste_sensitivity0.62781811
134MP0000627_abnormal_mammary_gland0.62669170
135MP0002796_impaired_skin_barrier0.61538907
136MP0006036_abnormal_mitochondrial_physio0.60096397
137MP0000538_abnormal_urinary_bladder0.60085096
138MP0004381_abnormal_hair_follicle0.60013818
139MP0004043_abnormal_pH_regulation0.57916348
140MP0002971_abnormal_brown_adipose0.57745927
141MP0003690_abnormal_glial_cell0.57739426
142MP0002060_abnormal_skin_morphology0.55902751
143MP0000579_abnormal_nail_morphology0.53503241
144MP0005535_abnormal_body_temperature0.52937321
145MP0003329_amyloid_beta_deposits0.51253739
146MP0003724_increased_susceptibility_to0.50003234
147MP0005464_abnormal_platelet_physiology0.48868868
148MP0003436_decreased_susceptibility_to0.47796884
149MP0009053_abnormal_anal_canal0.46461371
150MP0005395_other_phenotype0.46071446
151MP0004782_abnormal_surfactant_physiolog0.45528056
152MP0004947_skin_inflammation0.44890770
153MP0001845_abnormal_inflammatory_respons0.44443469
154MP0001663_abnormal_digestive_system0.43810434
155MP0003075_altered_response_to0.43163541
156MP0000639_abnormal_adrenal_gland0.42742187
157MP0003638_abnormal_response/metabolism_0.41079602
158MP0003453_abnormal_keratinocyte_physiol0.41011254
159MP0005670_abnormal_white_adipose0.40308376
160MP0003718_maternal_effect0.39601041
161MP0000230_abnormal_systemic_arterial0.38150756
162MP0005448_abnormal_energy_balance0.38049593
163MP0002928_abnormal_bile_duct0.37982650
164MP0001661_extended_life_span0.37837483
165MP0005381_digestive/alimentary_phenotyp0.37566799
166MP0010155_abnormal_intestine_physiology0.35972364
167MP0000249_abnormal_blood_vessel0.34983671
168MP0002135_abnormal_kidney_morphology0.34903061

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)7.56967586
2Deep venous thrombosis (HP:0002625)6.87537248
3Abnormality of aromatic amino acid family metabolism (HP:0004338)6.68761652
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.31501199
5Absent/shortened dynein arms (HP:0200106)6.27443700
6Dynein arm defect of respiratory motile cilia (HP:0012255)6.27443700
7Prolonged partial thromboplastin time (HP:0003645)6.21347090
8Respiratory insufficiency due to defective ciliary clearance (HP:0200073)6.13039696
9Complement deficiency (HP:0004431)5.96087749
10Abnormal respiratory epithelium morphology (HP:0012253)5.94853430
11Abnormal respiratory motile cilium morphology (HP:0005938)5.94853430
12Abnormal respiratory motile cilium physiology (HP:0012261)5.59043865
13Xanthomatosis (HP:0000991)5.58783500
14Abnormal ciliary motility (HP:0012262)5.54452980
15Hypobetalipoproteinemia (HP:0003563)5.31117178
16Rhinitis (HP:0012384)4.98465467
17Chronic bronchitis (HP:0004469)4.69248044
18Joint hemorrhage (HP:0005261)4.50284512
19Abnormality of the common coagulation pathway (HP:0010990)4.46675727
20Pancreatic cysts (HP:0001737)4.46327778
21Hyperlipoproteinemia (HP:0010980)4.44972215
22Hyperammonemia (HP:0001987)4.39856103
23Abnormality of complement system (HP:0005339)4.39175081
24Abnormality of glutamine family amino acid metabolism (HP:0010902)4.37833944
25Hyperglycinemia (HP:0002154)4.21969858
26Molar tooth sign on MRI (HP:0002419)4.20525651
27Abnormality of midbrain morphology (HP:0002418)4.20525651
28Fat malabsorption (HP:0002630)4.17783912
29Epidermoid cyst (HP:0200040)4.16148221
30Conjugated hyperbilirubinemia (HP:0002908)4.15705233
31Pancreatic fibrosis (HP:0100732)4.10524297
32Abnormality of sulfur amino acid metabolism (HP:0004339)4.07616170
33True hermaphroditism (HP:0010459)4.04373164
34Hypolipoproteinemia (HP:0010981)4.00998817
35Ketosis (HP:0001946)3.97662674
36Bronchiectasis (HP:0002110)3.94612635
37Hyperglycinuria (HP:0003108)3.85904284
38Polydipsia (HP:0001959)3.83075393
39Abnormal drinking behavior (HP:0030082)3.83075393
40Abnormality of the intrinsic pathway (HP:0010989)3.82283251
41Abnormality of methionine metabolism (HP:0010901)3.77630864
42Abnormality of aspartate family amino acid metabolism (HP:0010899)3.77288785
43Abnormality of serine family amino acid metabolism (HP:0010894)3.70089475
44Abnormality of glycine metabolism (HP:0010895)3.70089475
45Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.65109443
46Abnormality of the renal medulla (HP:0100957)3.59815099
47Nephronophthisis (HP:0000090)3.55315684
48Hypoalphalipoproteinemia (HP:0003233)3.53647423
49Hypomagnesemia (HP:0002917)3.49430819
50Cystic liver disease (HP:0006706)3.47441226
51Hyperactive renin-angiotensin system (HP:0000841)3.46322581
52Tubulointerstitial nephritis (HP:0001970)3.41599915
53Tubular atrophy (HP:0000092)3.39495005
54Abnormality of pyrimidine metabolism (HP:0004353)3.32992481
55Hypoglycemic coma (HP:0001325)3.29627300
56Hypercholesterolemia (HP:0003124)3.25293166
57Hyperbilirubinemia (HP:0002904)3.20966653
58Congenital stationary night blindness (HP:0007642)3.19982981
59Hepatocellular carcinoma (HP:0001402)3.19489845
60Abnormality of the renal cortex (HP:0011035)3.18280982
61Tetany (HP:0001281)3.15829190
62Abnormality of cochlea (HP:0000375)3.10016747
63Chronic hepatic failure (HP:0100626)3.09352714
64Steatorrhea (HP:0002570)3.06401561
65Abnormality of serum amino acid levels (HP:0003112)3.03981752
66Abnormality of nucleobase metabolism (HP:0010932)3.00838430
67Systemic lupus erythematosus (HP:0002725)2.99288199
68Polyuria (HP:0000103)2.97416806
69Spontaneous abortion (HP:0005268)2.93954371
70Ileus (HP:0002595)2.93382691
71Abnormality of fatty-acid metabolism (HP:0004359)2.88194692
72Abnormality of purine metabolism (HP:0004352)2.84761404
73Vascular calcification (HP:0004934)2.82002490
74Ketoacidosis (HP:0001993)2.81150936
75Nasal polyposis (HP:0100582)2.79276608
76Decreased circulating renin level (HP:0003351)2.79027762
77Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.76028122
78Acanthocytosis (HP:0001927)2.75559578
79Myocardial infarction (HP:0001658)2.73281228
80Abnormality of magnesium homeostasis (HP:0004921)2.70516126
81Hypochromic microcytic anemia (HP:0004840)2.68618769
82Thyroid-stimulating hormone excess (HP:0002925)2.67207366
83Medial flaring of the eyebrow (HP:0010747)2.65581534
84Recurrent gram-negative bacterial infections (HP:0005420)2.65251330
85Skin nodule (HP:0200036)2.61997578
86Gout (HP:0001997)2.61364819
87Furrowed tongue (HP:0000221)2.60383140
88Metabolic acidosis (HP:0001942)2.58654226
89Aplasia/Hypoplasia of the tongue (HP:0010295)2.58082773
90Abnormality of renal excretion (HP:0011036)2.56331582
91Congenital, generalized hypertrichosis (HP:0004540)2.56295041
92Delayed CNS myelination (HP:0002188)2.54843699
93Lethargy (HP:0001254)2.53019448
94Cardiovascular calcification (HP:0011915)2.51311587
95Esophageal varix (HP:0002040)2.50181314
96Glomerulonephritis (HP:0000099)2.47869856
97Hyperkalemia (HP:0002153)2.47794731
98Abnormality of renin-angiotensin system (HP:0000847)2.47083119
99Congenital hepatic fibrosis (HP:0002612)2.46890274
100Hyperaldosteronism (HP:0000859)2.45870327
101Renal salt wasting (HP:0000127)2.45551627
102Cerebral edema (HP:0002181)2.43665840
103Spastic diplegia (HP:0001264)2.42985455
104Sclerocornea (HP:0000647)2.39454380
105Clumsiness (HP:0002312)2.39108615
106Stomach cancer (HP:0012126)2.38479865
107Postaxial foot polydactyly (HP:0001830)2.36919220
108Abnormal urine output (HP:0012590)2.36596998
109Bronchitis (HP:0012387)2.33557767
110Fair hair (HP:0002286)2.32062770
111Chronic sinusitis (HP:0011109)2.30196834
112Hemorrhage of the eye (HP:0011885)2.29491461
113Abnormality of dicarboxylic acid metabolism (HP:0010995)2.28850998
114Dicarboxylic aciduria (HP:0003215)2.28850998
115Abnormality of chloride homeostasis (HP:0011422)2.27975937
116Type II lissencephaly (HP:0007260)2.27804144
117Alkalosis (HP:0001948)2.27766311
118Neonatal onset (HP:0003623)2.25349940
119Hyperventilation (HP:0002883)2.24946556
120Amyloidosis (HP:0011034)2.23853910
121Pendular nystagmus (HP:0012043)2.23817491
122Menorrhagia (HP:0000132)2.23368541
123Abnormal gallbladder morphology (HP:0012437)2.22915986
124Gingival bleeding (HP:0000225)2.22822212
125Occipital encephalocele (HP:0002085)2.18588661
126Widely spaced teeth (HP:0000687)2.18406056
127Mitral stenosis (HP:0001718)2.17377539
128Tubulointerstitial abnormality (HP:0001969)2.17300666
129Pancreatitis (HP:0001733)2.16613216
130Cholelithiasis (HP:0001081)2.15297800
131Abnormality of proline metabolism (HP:0010907)2.12425698
132Hydroxyprolinuria (HP:0003080)2.12425698
133Abnormality of transition element cation homeostasis (HP:0011030)2.11592077
134Irritability (HP:0000737)2.11171011
135Genetic anticipation (HP:0003743)2.10189745
136Hypothermia (HP:0002045)2.08879924
137Nephritis (HP:0000123)2.07072998
138Absent speech (HP:0001344)2.06292791
139Gaze-evoked nystagmus (HP:0000640)2.06097790
140Morphological abnormality of the inner ear (HP:0011390)2.05638757
141Decreased central vision (HP:0007663)2.05269963
142Male pseudohermaphroditism (HP:0000037)2.05040328
143Hypokalemic alkalosis (HP:0001949)2.04466447
144Abnormal enzyme/coenzyme activity (HP:0012379)2.04293470
145Attenuation of retinal blood vessels (HP:0007843)2.03845738
146Anencephaly (HP:0002323)2.01771435
147Hypoglycemic seizures (HP:0002173)2.01605384
148Poikilocytosis (HP:0004447)2.01150972
149Large for gestational age (HP:0001520)2.00435992
150Sensorimotor neuropathy (HP:0007141)2.00173130
151Spinal muscular atrophy (HP:0007269)1.99811813
152Fibular aplasia (HP:0002990)1.99363671
153Generalized hypopigmentation of hair (HP:0011358)1.99350804
154Malnutrition (HP:0004395)1.98034565
155Aplasia/hypoplasia of the uterus (HP:0008684)1.97387659
156Vomiting (HP:0002013)1.97123503
157Stage 5 chronic kidney disease (HP:0003774)1.95569036
158Abnormality of the gallbladder (HP:0005264)1.95343046
159Abnormality of the nasal mucosa (HP:0000433)1.94900842
160Thrombophlebitis (HP:0004418)1.93929230
161Abolished electroretinogram (ERG) (HP:0000550)1.93614332
162Congenital primary aphakia (HP:0007707)1.93064587
163Chorioretinal atrophy (HP:0000533)1.91108674
164Protuberant abdomen (HP:0001538)1.91018717
165Gait imbalance (HP:0002141)1.90622859
166Amelogenesis imperfecta (HP:0000705)1.90417396
167Generalized aminoaciduria (HP:0002909)1.89959404
168Rickets (HP:0002748)1.89150964
169Infertility (HP:0000789)1.86169602
170Abnormality of iron homeostasis (HP:0011031)1.85151971
171Elevated alkaline phosphatase (HP:0003155)1.84952575
172Abnormal cartilage morphology (HP:0002763)1.84463694
173Enlarged kidneys (HP:0000105)1.83366868
174Nephrogenic diabetes insipidus (HP:0009806)1.81825406
175Abnormality of alkaline phosphatase activity (HP:0004379)1.81437266
176Mucopolysacchariduria (HP:0008155)1.80796050
177Urinary glycosaminoglycan excretion (HP:0003541)1.80796050
178Elevated hepatic transaminases (HP:0002910)1.79472577
179Disproportionate short-trunk short stature (HP:0003521)1.76538874
180Tubulointerstitial fibrosis (HP:0005576)1.76365662
181Abnormality of macular pigmentation (HP:0008002)1.76055014
182Abnormal gallbladder physiology (HP:0012438)1.75822827
183Cholecystitis (HP:0001082)1.75822827
184Oculomotor apraxia (HP:0000657)1.75001867
185Chronic otitis media (HP:0000389)1.74402313
186Broad-based gait (HP:0002136)1.72716837
187Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.72063114
188Abnormality of alanine metabolism (HP:0010916)1.72063114
189Hyperalaninemia (HP:0003348)1.72063114
190Inability to walk (HP:0002540)1.71666016
191Aplasia/Hypoplasia of the spleen (HP:0010451)1.71172422
192Abnormality of vitamin metabolism (HP:0100508)1.71109948
193Recurrent sinusitis (HP:0011108)1.69166772
194Renal cortical cysts (HP:0000803)1.63126902
195Hyperuricemia (HP:0002149)1.62137914
196Increased purine levels (HP:0004368)1.62137914
197Hypoplasia of the uterus (HP:0000013)1.60975022
198Postaxial hand polydactyly (HP:0001162)1.60255919
199Abnormal rod and cone electroretinograms (HP:0008323)1.59707401
200Decreased electroretinogram (ERG) amplitude (HP:0000654)1.57894845

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LMTK26.25902632
2BCKDK4.88155895
3TAOK34.44829945
4ERN14.02410410
5FRK3.76175454
6SIK13.76118555
7MAPK153.13766023
8NEK13.11698223
9FGFR42.68624933
10MST1R2.64792827
11ADRBK22.64455926
12AKT32.63668244
13BMPR1B2.59082133
14ERBB42.53518525
15INSRR2.48432734
16WNK42.35276010
17ACVR1B1.80686674
18BRSK21.80362643
19TLK11.77940984
20LATS11.73602616
21WNK31.71370495
22PKN21.57316111
23MAPK111.52870261
24PRKG21.50547855
25MAP4K21.50340946
26PTK61.48477793
27PTK2B1.46462244
28ERBB21.43000005
29PRKCI1.31228970
30NUAK11.23552070
31FLT31.20549977
32JAK21.18873771
33CAMKK21.17048772
34MAP2K41.15993980
35PIK3CG1.14236289
36TRIB31.13898626
37EIF2AK31.11175937
38PRKCE1.09506893
39MET1.08925713
40EPHA21.08235735
41ADRBK11.07812870
42STK391.07621272
43MST41.06695371
44DAPK21.06086164
45ZAK1.05952865
46MAP3K71.05205776
47MAP3K141.04731218
48CDK81.04526525
49PRKAA20.99186586
50NME10.95722403
51ERBB30.95230117
52TYK20.93645313
53MKNK20.92118067
54PHKG20.90750116
55PHKG10.90750116
56TRPM70.90473566
57EPHB10.90024389
58NME20.82686286
59MAP3K30.81566234
60TGFBR10.81125457
61IRAK30.80249996
62TBK10.78836948
63PKN10.76878190
64PRKAA10.75467988
65JAK10.74912989
66TRIM280.73480546
67TGFBR20.72172392
68STK30.69920003
69SGK20.69718745
70SGK30.68000451
71CASK0.67841907
72STK380.67410996
73STK38L0.67277162
74NEK90.65033715
75BCR0.64968304
76MYLK0.63677938
77MAPK130.63075926
78MAP2K30.62218654
79MAP3K100.60833718
80MAP3K20.59856460
81PAK30.59689956
82MAP2K60.57662392
83MAPK40.57346829
84PIK3CA0.57146394
85GRK10.57010747
86FGFR20.55443821
87STK100.55026195
88ABL20.54977012
89EEF2K0.54834693
90OXSR10.53903189
91CAMK2G0.53529395
92TXK0.52254545
93MAP2K20.51526217
94PRKCZ0.50995484
95CDK60.50116918
96RIPK10.49603729
97MAPK120.49472654
98EIF2AK20.49216836
99CAMK1D0.48792401
100SGK4940.48602908
101SGK2230.48602908
102MAP3K130.48518773
103GSK3A0.47544058
104PRKCQ0.45226450
105GRK60.44427352
106ZAP700.44151983
107PRKACG0.44103481
108PBK0.43948303
109CSNK1A10.43122860
110NEK20.42661004
111MAP3K120.40831997
112RET0.39920913
113MAPKAPK30.38992782
114FGFR30.37690685
115MAP3K40.37408895
116ABL10.37234007
117PTK20.36919595
118IKBKE0.36675441
119JAK30.35832403
120TNIK0.35023041
121KIT0.34836440
122IRAK10.34751953
123FER0.34693353
124CSF1R0.33337512
125CSK0.32992985
126PDK20.32312061
127PINK10.32154111
128PNCK0.31206962
129MAP2K10.31011792
130PRKCG0.30947927
131CAMK2A0.30919847
132TIE10.30033168
133BMX0.29739048
134VRK10.28581306
135STK40.28572957
136EGFR0.28298945
137ROCK10.26917524
138PDPK10.26086267
139PLK20.25088245
140IGF1R0.24169444
141PRKCD0.23937884
142BRSK10.23862746
143KDR0.23234933
144EPHA40.22321166
145MTOR0.22160969
146RPS6KB10.21713147
147MAP3K110.21306631
148CHUK0.21267638
149MUSK0.21077591
150PRKCA0.21013501
151LRRK20.20481795
152PRKACA0.20181361
153IKBKB0.19269176
154CSNK1D0.19095553
155CSNK1A1L0.13737269
156MAP2K70.13444164

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.73430590
2Nitrogen metabolism_Homo sapiens_hsa009103.86188302
3Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005333.34567448
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.28053960
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.22326959
6Arginine biosynthesis_Homo sapiens_hsa002203.15226737
7Complement and coagulation cascades_Homo sapiens_hsa046102.87038140
8Tryptophan metabolism_Homo sapiens_hsa003802.66706609
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.59230320
10Phototransduction_Homo sapiens_hsa047442.47970219
11Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.44718455
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.39474574
13Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005122.38164599
14Fatty acid degradation_Homo sapiens_hsa000712.37672694
15Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.32509593
16Caffeine metabolism_Homo sapiens_hsa002322.19350033
17Pentose and glucuronate interconversions_Homo sapiens_hsa000402.18651370
18Peroxisome_Homo sapiens_hsa041462.06672244
19Propanoate metabolism_Homo sapiens_hsa006401.98371189
20Histidine metabolism_Homo sapiens_hsa003401.95578081
21Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.94295110
22Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.93434562
23Butanoate metabolism_Homo sapiens_hsa006501.91418611
24Steroid hormone biosynthesis_Homo sapiens_hsa001401.83203258
25Sulfur metabolism_Homo sapiens_hsa009201.78270678
26PPAR signaling pathway_Homo sapiens_hsa033201.78108763
27Chemical carcinogenesis_Homo sapiens_hsa052041.77219630
28Staphylococcus aureus infection_Homo sapiens_hsa051501.76576676
29Salivary secretion_Homo sapiens_hsa049701.75434901
30Selenocompound metabolism_Homo sapiens_hsa004501.74030447
31Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.71388667
32Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.69427785
33Fatty acid metabolism_Homo sapiens_hsa012121.67285452
34Drug metabolism - other enzymes_Homo sapiens_hsa009831.66526860
35Retinol metabolism_Homo sapiens_hsa008301.64232537
36beta-Alanine metabolism_Homo sapiens_hsa004101.58898810
37Bile secretion_Homo sapiens_hsa049761.58501558
38Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.54322218
39Intestinal immune network for IgA production_Homo sapiens_hsa046721.52546356
40Ether lipid metabolism_Homo sapiens_hsa005651.50465947
41Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.48208147
422-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.45370000
43Phenylalanine metabolism_Homo sapiens_hsa003601.45085080
44Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.43595899
45ABC transporters_Homo sapiens_hsa020101.41687177
46Steroid biosynthesis_Homo sapiens_hsa001001.34338987
47Tyrosine metabolism_Homo sapiens_hsa003501.33333062
48Pyruvate metabolism_Homo sapiens_hsa006201.31284905
49Asthma_Homo sapiens_hsa053101.30270751
50Starch and sucrose metabolism_Homo sapiens_hsa005001.29779366
51Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.28782129
52Sphingolipid metabolism_Homo sapiens_hsa006001.26049444
53Cysteine and methionine metabolism_Homo sapiens_hsa002701.21046694
54Biosynthesis of amino acids_Homo sapiens_hsa012301.16289158
55Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.13951589
56Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.12979436
57Fatty acid elongation_Homo sapiens_hsa000621.11846391
58Folate biosynthesis_Homo sapiens_hsa007901.10160459
59Carbon metabolism_Homo sapiens_hsa012001.08656585
60Fat digestion and absorption_Homo sapiens_hsa049751.08119448
61Olfactory transduction_Homo sapiens_hsa047401.04478858
62Homologous recombination_Homo sapiens_hsa034401.03661570
63Taste transduction_Homo sapiens_hsa047420.99196425
64RNA polymerase_Homo sapiens_hsa030200.98887776
65Cyanoamino acid metabolism_Homo sapiens_hsa004600.98109500
66Arginine and proline metabolism_Homo sapiens_hsa003300.97545851
67Maturity onset diabetes of the young_Homo sapiens_hsa049500.92661474
68Vitamin digestion and absorption_Homo sapiens_hsa049770.89988448
69Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.89862203
70Nicotine addiction_Homo sapiens_hsa050330.88898499
71Circadian rhythm_Homo sapiens_hsa047100.88895781
72Graft-versus-host disease_Homo sapiens_hsa053320.86849648
73Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.86095482
74Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.84957683
75Basal transcription factors_Homo sapiens_hsa030220.81731000
76Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.81013161
77Lysine degradation_Homo sapiens_hsa003100.80728656
78Autoimmune thyroid disease_Homo sapiens_hsa053200.78111397
79Fatty acid biosynthesis_Homo sapiens_hsa000610.77829836
80Ovarian steroidogenesis_Homo sapiens_hsa049130.77402923
81Regulation of autophagy_Homo sapiens_hsa041400.77344285
82Sulfur relay system_Homo sapiens_hsa041220.76661096
83Huntingtons disease_Homo sapiens_hsa050160.76613822
84Vitamin B6 metabolism_Homo sapiens_hsa007500.76445544
85Proteasome_Homo sapiens_hsa030500.74620642
86Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.72055776
87Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.69106873
88Allograft rejection_Homo sapiens_hsa053300.65633523
89Type I diabetes mellitus_Homo sapiens_hsa049400.65588078
90Pentose phosphate pathway_Homo sapiens_hsa000300.65069797
91Glutathione metabolism_Homo sapiens_hsa004800.64474204
92Glycerolipid metabolism_Homo sapiens_hsa005610.63630916
93Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.62917948
94Tight junction_Homo sapiens_hsa045300.61366666
95Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.59922336
96One carbon pool by folate_Homo sapiens_hsa006700.59358900
97Serotonergic synapse_Homo sapiens_hsa047260.58790432
98Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.54465588
99SNARE interactions in vesicular transport_Homo sapiens_hsa041300.54200973
100Pancreatic secretion_Homo sapiens_hsa049720.51657726
101Galactose metabolism_Homo sapiens_hsa000520.48626979
102Purine metabolism_Homo sapiens_hsa002300.47941020
103Metabolic pathways_Homo sapiens_hsa011000.47357355
104Prion diseases_Homo sapiens_hsa050200.47121008
105Calcium signaling pathway_Homo sapiens_hsa040200.45345456
106Pyrimidine metabolism_Homo sapiens_hsa002400.42899330
107Oxidative phosphorylation_Homo sapiens_hsa001900.42501116
108Dorso-ventral axis formation_Homo sapiens_hsa043200.41367954
109Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.39368540
110Fanconi anemia pathway_Homo sapiens_hsa034600.39297805
111Fructose and mannose metabolism_Homo sapiens_hsa000510.38962805
112Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.38398332
113Insulin secretion_Homo sapiens_hsa049110.35784549
114Protein export_Homo sapiens_hsa030600.34268402
115Morphine addiction_Homo sapiens_hsa050320.33340462
116Insulin resistance_Homo sapiens_hsa049310.27664221
117Antigen processing and presentation_Homo sapiens_hsa046120.24387794
118Non-homologous end-joining_Homo sapiens_hsa034500.24001734
119Hematopoietic cell lineage_Homo sapiens_hsa046400.23811445
120RNA degradation_Homo sapiens_hsa030180.23396449
121alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.22550446
122Circadian entrainment_Homo sapiens_hsa047130.20975674
123Glutamatergic synapse_Homo sapiens_hsa047240.20254804
124Glycosaminoglycan degradation_Homo sapiens_hsa005310.20178298
125Collecting duct acid secretion_Homo sapiens_hsa049660.19688369
126Adipocytokine signaling pathway_Homo sapiens_hsa049200.19303944
127Linoleic acid metabolism_Homo sapiens_hsa005910.16503221
128Other glycan degradation_Homo sapiens_hsa005110.09420892
129Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.09245913
130Glycerophospholipid metabolism_Homo sapiens_hsa005640.07544178
131Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.07521290
132Glucagon signaling pathway_Homo sapiens_hsa049220.06909231
133Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.05504229
134AMPK signaling pathway_Homo sapiens_hsa041520.04973339
135Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.03177868
136Hepatitis C_Homo sapiens_hsa051600.02036357
137Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.01551323
138Lysosome_Homo sapiens_hsa04142-0.1851625
139Protein digestion and absorption_Homo sapiens_hsa04974-0.1786362
140Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.1652411
141Bladder cancer_Homo sapiens_hsa05219-0.1242898
142Pertussis_Homo sapiens_hsa05133-0.1190173
143Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1135464
144Insulin signaling pathway_Homo sapiens_hsa04910-0.1083122
145African trypanosomiasis_Homo sapiens_hsa05143-0.0798648
146Arachidonic acid metabolism_Homo sapiens_hsa00590-0.0675570
147Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603-0.0588986
148Mineral absorption_Homo sapiens_hsa04978-0.0507876
149Amoebiasis_Homo sapiens_hsa05146-0.0241061
150Thyroid hormone synthesis_Homo sapiens_hsa04918-0.0042891
151Renin-angiotensin system_Homo sapiens_hsa04614-0.0008682

Most similar genes based on co-expression Upload to Enrichr

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