ADGRE3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the class B seven-span transmembrane (TM7) receptor family expressed predominantly by cells of the immune system. Family members are characterized by an extended extracellular region with a variable number of N-terminal epidermal growth factor (EGF)-like domains coupled to a TM7 domain via a mucin-like spacer domain. This gene is closely linked to the gene encoding egf-like molecule containing mucin-like hormone receptor 2 on chromosome 19. This protein may play a role in myeloid-myeloid interactions during immune and inflammatory responses. Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1modulation by organism of immune response of other organism involved in symbiotic interaction (GO:006.53560528
2modulation by organism of defense response of other organism involved in symbiotic interaction (GO:06.53560528
3positive regulation by organism of defense response of other organism involved in symbiotic interact6.53560528
4modulation by symbiont of host immune response (GO:0052553)6.53560528
5positive regulation by symbiont of host defense response (GO:0052509)6.53560528
6modulation by symbiont of host defense response (GO:0052031)6.53560528
7antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.44757249
8negative regulation of cell killing (GO:0031342)6.39700904
9negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.39700904
10positive regulation of gamma-delta T cell activation (GO:0046645)5.85278362
11detection of molecule of bacterial origin (GO:0032490)5.62818947
12neutrophil activation involved in immune response (GO:0002283)5.35433982
13regulation of B cell receptor signaling pathway (GO:0050855)5.35376237
14macrophage activation involved in immune response (GO:0002281)5.33806920
15detection of other organism (GO:0098543)5.24944113
16antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.17747809
17antigen processing and presentation of endogenous antigen (GO:0019883)5.00432538
18cellular extravasation (GO:0045123)4.98523110
19positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.96372040
20detection of external biotic stimulus (GO:0098581)4.95723293
21response to peptidoglycan (GO:0032494)4.91744078
22detection of bacterium (GO:0016045)4.78280607
23neutrophil activation (GO:0042119)4.64948075
24microglial cell activation (GO:0001774)4.63184174
25regulation of interferon-beta biosynthetic process (GO:0045357)4.62599481
26antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.57811429
27positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.49402585
28negative regulation of interleukin-12 production (GO:0032695)4.48531342
29response to host immune response (GO:0052572)4.41639128
30response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.41639128
31negative regulation of lymphocyte mediated immunity (GO:0002707)4.40330786
32respiratory burst (GO:0045730)4.39685415
33response to interleukin-15 (GO:0070672)4.36106472
34neutrophil mediated immunity (GO:0002446)4.35662148
35detection of biotic stimulus (GO:0009595)4.33086626
36regulation of gamma-delta T cell activation (GO:0046643)4.24544109
37leukocyte aggregation (GO:0070486)4.21450991
38leukocyte migration involved in inflammatory response (GO:0002523)4.20721312
39macrophage activation (GO:0042116)4.18943757
40granulocyte activation (GO:0036230)4.16647784
41cellular response to interleukin-15 (GO:0071350)4.06688864
42response to host (GO:0075136)4.04375588
43response to host defenses (GO:0052200)4.04375588
44response to defenses of other organism involved in symbiotic interaction (GO:0052173)4.04375588
45positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.99493964
46myeloid cell activation involved in immune response (GO:0002275)3.86621250
47negative regulation of leukocyte mediated immunity (GO:0002704)3.81622230
48regulation of mast cell degranulation (GO:0043304)3.79680933
49production of molecular mediator involved in inflammatory response (GO:0002532)3.77624856
50regulation of gamma-delta T cell differentiation (GO:0045586)3.77446962
51negative regulation of T cell mediated immunity (GO:0002710)3.73507141
52negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.68846666
53negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.64971729
54myeloid leukocyte mediated immunity (GO:0002444)3.62647383
55immunoglobulin mediated immune response (GO:0016064)3.60325764
56positive regulation of mast cell activation (GO:0033005)3.58038335
57regulation of mast cell activation involved in immune response (GO:0033006)3.50832249
58B cell receptor signaling pathway (GO:0050853)3.44432660
59regulation of myeloid leukocyte mediated immunity (GO:0002886)3.43986960
60antigen processing and presentation via MHC class Ib (GO:0002475)3.40193019
61leukocyte degranulation (GO:0043299)3.39570289
62regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.36967161
63regulation of mast cell activation (GO:0033003)3.36880058
64regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.30977276
65regulation of leukocyte degranulation (GO:0043300)3.29873141
66dendritic cell migration (GO:0036336)3.28864105
67regulation of B cell differentiation (GO:0045577)3.23278207
68negative regulation of phagocytosis (GO:0050765)3.22483044
69regulation of tolerance induction (GO:0002643)3.20561705
70germinal center formation (GO:0002467)3.16904007
71lipopolysaccharide-mediated signaling pathway (GO:0031663)3.15335859
72response to muramyl dipeptide (GO:0032495)3.14049402
73dendritic cell chemotaxis (GO:0002407)3.14018064
74regulation of T cell tolerance induction (GO:0002664)3.12593921
75regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.11136174
76defense response to protozoan (GO:0042832)3.09896221
77regulation of regulated secretory pathway (GO:1903305)3.09345198
78positive regulation of mast cell activation involved in immune response (GO:0033008)3.06572422
79positive regulation of mast cell degranulation (GO:0043306)3.06572422
80positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.05607342
81regulation of T-helper 2 cell differentiation (GO:0045628)3.05185067
82positive regulation of cellular amide metabolic process (GO:0034250)3.04844977
83type I interferon signaling pathway (GO:0060337)3.04037947
84cellular response to type I interferon (GO:0071357)3.04037947
85negative regulation of T-helper cell differentiation (GO:0045623)3.03359757
86negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.03359757
87myeloid leukocyte activation (GO:0002274)3.03010918
88negative regulation of interleukin-6 production (GO:0032715)3.02611405
89response to type I interferon (GO:0034340)3.01831405
90neutrophil chemotaxis (GO:0030593)2.99620007
91tolerance induction (GO:0002507)2.97440770
92negative thymic T cell selection (GO:0045060)2.97326030
93negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.95753558
94regulation of T cell mediated cytotoxicity (GO:0001914)2.92927884
95neutrophil migration (GO:1990266)2.92106395
96negative T cell selection (GO:0043383)2.91891820
97positive regulation of T cell mediated cytotoxicity (GO:0001916)2.91685686
98positive regulation of B cell differentiation (GO:0045579)2.91541333
99negative regulation of type 2 immune response (GO:0002829)2.91141885
100positive regulation of toll-like receptor signaling pathway (GO:0034123)2.90629333

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human5.18558184
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.93129043
3IRF8_21731497_ChIP-ChIP_J774_Mouse4.42035256
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.08198414
5MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.90295019
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.74777889
7SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.43837926
8IRF8_27001747_Chip-Seq_BMDM_Mouse3.37249830
9MYB_21317192_ChIP-Seq_ERMYB_Mouse3.01882937
10NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.94569819
11SPI1_23547873_ChIP-Seq_NB4_Human2.86852325
12RUNX_20019798_ChIP-Seq_JUKART_Human2.85891209
13STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.83056754
14SPI1_23127762_ChIP-Seq_K562_Human2.77317341
15IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.74034280
16IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.62918338
17VDR_24763502_ChIP-Seq_THP-1_Human2.56927487
18SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.41778409
19RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.40609890
20VDR_21846776_ChIP-Seq_THP-1_Human2.37230469
21MYB_26560356_Chip-Seq_TH2_Human2.34972328
22FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.31930620
23SCL_19346495_ChIP-Seq_HPC-7_Human2.29647700
24MAF_26560356_Chip-Seq_TH1_Human2.28287553
25RUNX1_22412390_ChIP-Seq_EML_Mouse2.22714428
26Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.20498477
27BRD4_27068464_Chip-Seq_AML-cells_Mouse2.18229813
28E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.18019237
29SMAD_19615063_ChIP-ChIP_OVARY_Human2.06786328
30UTX_26944678_Chip-Seq_JUKART_Human2.04251950
31NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.03804163
32STAT4_19710469_ChIP-ChIP_TH1__Mouse2.03672840
33MYB_26560356_Chip-Seq_TH1_Human2.03098404
34VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.00079829
35VDR_24787735_ChIP-Seq_THP-1_Human1.93270811
36TCF7_22412390_ChIP-Seq_EML_Mouse1.87747783
37CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.77800884
38MYC_22102868_ChIP-Seq_BL_Human1.77546490
39KDM2B_26808549_Chip-Seq_SUP-B15_Human1.76627970
40MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.75481697
41RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.74318435
42GATA3_27048872_Chip-Seq_THYMUS_Human1.74094708
43NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.69413757
44EGR1_19374776_ChIP-ChIP_THP-1_Human1.64433869
45LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.62496971
46GATA1_19941827_ChIP-Seq_MEL_Mouse1.61968420
47MAF_26560356_Chip-Seq_TH2_Human1.59465876
48CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.57854539
49TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.54796013
50KDM2B_26808549_Chip-Seq_DND41_Human1.52522645
51STAT6_21828071_ChIP-Seq_BEAS2B_Human1.50657269
52GATA1_22025678_ChIP-Seq_K562_Human1.46873894
53PU_27001747_Chip-Seq_BMDM_Mouse1.42061560
54GATA3_26560356_Chip-Seq_TH2_Human1.41860639
55LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.40659463
56GATA2_22383799_ChIP-Seq_G1ME_Mouse1.39624022
57PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.39374733
58KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.36677966
59KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.35113487
60FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.34199185
61CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.34131866
62PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.33574130
63PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.31377613
64GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.30321555
65STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.30318992
66GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.25105468
67THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.25097633
68SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.24876225
69SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.21728544
70CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.21150535
71GATA1_22383799_ChIP-Seq_G1ME_Mouse1.20663664
72CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.20329969
73SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.17102487
74GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.16557531
75GATA2_21666600_ChIP-Seq_HMVEC_Human1.14966269
76GATA1_19941826_ChIP-Seq_K562_Human1.11859310
77SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.09874896
78KDM2B_26808549_Chip-Seq_JURKAT_Human1.09743034
79PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.09539936
80VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.09194373
81RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.05398797
82ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.04132362
83BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.03466290
84ELK3_25401928_ChIP-Seq_HUVEC_Human1.02942626
85GATA2_19941826_ChIP-Seq_K562_Human1.02582233
86PU.1_20513432_ChIP-Seq_Bcells_Mouse0.99071223
87IKZF1_21737484_ChIP-ChIP_HCT116_Human0.98548907
88SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.98016883
89NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.91839344
90BCL6_27268052_Chip-Seq_Bcells_Human0.87077177
91ELF1_17652178_ChIP-ChIP_JURKAT_Human0.86061827
92GATA1_19941827_ChIP-Seq_MEL86_Mouse0.85616649
93RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85544120
94LXR_22292898_ChIP-Seq_THP-1_Human0.80268029
95SMRT_27268052_Chip-Seq_Bcells_Human0.79223208
96STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.78859404
97NCOR1_26117541_ChIP-Seq_K562_Human0.78048129
98BCOR_27268052_Chip-Seq_Bcells_Human0.77834291
99SPI1_20517297_ChIP-Seq_HL60_Human0.75700880
100FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.72701602

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to5.63305402
2MP0003436_decreased_susceptibility_to4.32193486
3MP0003303_peritoneal_inflammation4.00227559
4MP0001835_abnormal_antigen_presentation3.62708887
5MP0002419_abnormal_innate_immunity3.23825314
6MP0005025_abnormal_response_to2.85326933
7MP0001800_abnormal_humoral_immune2.84305562
8MP0005671_abnormal_response_to2.79552814
9MP0009785_altered_susceptibility_to2.78704376
10MP0005000_abnormal_immune_tolerance2.72606647
11MP0000685_abnormal_immune_system2.68878821
12MP0001790_abnormal_immune_system2.60117028
13MP0005387_immune_system_phenotype2.60117028
14MP0008260_abnormal_autophagy2.54747356
15MP0002723_abnormal_immune_serum2.54261527
16MP0003191_abnormal_cellular_cholesterol2.52413973
17MP0002420_abnormal_adaptive_immunity2.49188579
18MP0006082_CNS_inflammation2.47467828
19MP0001819_abnormal_immune_cell2.46555546
20MP0002452_abnormal_antigen_presenting2.43898405
21MP0003300_gastrointestinal_ulcer2.34767513
22MP0001533_abnormal_skeleton_physiology2.19979637
23MP0002148_abnormal_hypersensitivity_rea2.19671283
24MP0002132_abnormal_respiratory_system2.10494649
25MP0005464_abnormal_platelet_physiology2.04715282
26MP0002405_respiratory_system_inflammati2.02199667
27MP0003828_pulmonary_edema1.96128635
28MP0003763_abnormal_thymus_physiology1.94454256
29MP0002277_abnormal_respiratory_mucosa1.91544385
30MP0004381_abnormal_hair_follicle1.87715999
31MP0002398_abnormal_bone_marrow1.87383314
32MP0000716_abnormal_immune_system1.84018647
33MP0003172_abnormal_lysosome_physiology1.80655355
34MP0005451_abnormal_body_composition1.78772667
35MP0009278_abnormal_bone_marrow1.72229205
36MP0001845_abnormal_inflammatory_respons1.71794079
37MP0004883_abnormal_blood_vessel1.71089326
38MP0003866_abnormal_defecation1.66146887
39MP0009764_decreased_sensitivity_to1.63556427
40MP0010155_abnormal_intestine_physiology1.62931622
41MP0004947_skin_inflammation1.59572921
42MP0003183_abnormal_peptide_metabolism1.58926205
43MP0000465_gastrointestinal_hemorrhage1.57018501
44MP0002722_abnormal_immune_system1.55108435
45MP0002396_abnormal_hematopoietic_system1.54910149
46MP0000689_abnormal_spleen_morphology1.53125970
47MP0002429_abnormal_blood_cell1.44738541
48MP0009333_abnormal_splenocyte_physiolog1.40718028
49MP0008469_abnormal_protein_level1.38351323
50MP0000858_altered_metastatic_potential1.37917423
51MP0000703_abnormal_thymus_morphology1.37863955
52MP0005164_abnormal_response_to1.34414289
53MP0005310_abnormal_salivary_gland1.27724955
54MP0003075_altered_response_to1.27646454
55MP0003690_abnormal_glial_cell1.24136269
56MP0001545_abnormal_hematopoietic_system1.23347255
57MP0005397_hematopoietic_system_phenotyp1.23347255
58MP0001851_eye_inflammation1.21442318
59MP0000569_abnormal_digit_pigmentation1.20249599
60MP0002998_abnormal_bone_remodeling1.12673462
61MP0004510_myositis1.10525589
62MP0002166_altered_tumor_susceptibility1.07909941
63MP0005166_decreased_susceptibility_to0.98298503
64MP0005075_abnormal_melanosome_morpholog0.95555772
65MP0003448_altered_tumor_morphology0.94633388
66MP0003656_abnormal_erythrocyte_physiolo0.92835725
67MP0000015_abnormal_ear_pigmentation0.89635973
68MP0003221_abnormal_cardiomyocyte_apopto0.86238467
69MP0005390_skeleton_phenotype0.84349746
70MP0008004_abnormal_stomach_pH0.83147697
71MP0003045_fibrosis0.83046152
72MP0000604_amyloidosis0.81935733
73MP0001663_abnormal_digestive_system0.81361448
74MP0009763_increased_sensitivity_to0.80825264
75MP0000343_altered_response_to0.80748823
76MP0002928_abnormal_bile_duct0.79218287
77MP0004130_abnormal_muscle_cell0.75714867
78MP0003252_abnormal_bile_duct0.73495622
79MP0004808_abnormal_hematopoietic_stem0.70064403
80MP0002332_abnormal_exercise_endurance0.68443171
81MP0009765_abnormal_xenobiotic_induced0.67344516
82MP0000490_abnormal_crypts_of0.66394821
83MP0000249_abnormal_blood_vessel0.65985855
84MP0001853_heart_inflammation0.65883200
85MP0002006_tumorigenesis0.65429155
86MP0008874_decreased_physiological_sensi0.63906375
87MP0004484_altered_response_of0.63109161
88MP0005084_abnormal_gallbladder_morpholo0.62660737
89MP0001986_abnormal_taste_sensitivity0.61731146
90MP0005388_respiratory_system_phenotype0.61700200
91MP0002133_abnormal_respiratory_system0.61700200
92MP0003878_abnormal_ear_physiology0.60855609
93MP0005377_hearing/vestibular/ear_phenot0.60855609
94MP0005058_abnormal_lysosome_morphology0.58925832
95MP0003795_abnormal_bone_structure0.58485197
96MP0000371_diluted_coat_color0.55634368
97MP0001958_emphysema0.54633282
98MP0005376_homeostasis/metabolism_phenot0.53252621
99MP0005248_abnormal_Harderian_gland0.52258168
100MP0004858_abnormal_nervous_system0.51585004

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)6.99794444
2Recurrent abscess formation (HP:0002722)6.30586122
3Recurrent bacterial skin infections (HP:0005406)6.28636977
4Myositis (HP:0100614)6.23263050
5Orchitis (HP:0100796)6.12882699
6Retrobulbar optic neuritis (HP:0100654)5.79910798
7Optic neuritis (HP:0100653)5.79910798
8Abnormality of macrophages (HP:0004311)5.33346841
9Recurrent gram-negative bacterial infections (HP:0005420)5.26219939
10Stomatitis (HP:0010280)5.04877968
11Elevated erythrocyte sedimentation rate (HP:0003565)4.80683562
12Gastrointestinal infarctions (HP:0005244)4.50365722
13Keratoconjunctivitis sicca (HP:0001097)4.28604751
14Recurrent fungal infections (HP:0002841)4.25473144
15Chronic obstructive pulmonary disease (HP:0006510)4.19447903
16Obstructive lung disease (HP:0006536)4.19447903
17Abnormal delayed hypersensitivity skin test (HP:0002963)4.16775971
18Hypochromic microcytic anemia (HP:0004840)4.13914282
19Recurrent skin infections (HP:0001581)4.05336906
20Mediastinal lymphadenopathy (HP:0100721)4.03489046
21Meningitis (HP:0001287)4.02527478
22Keratoconjunctivitis (HP:0001096)3.96265034
23Spontaneous hematomas (HP:0007420)3.93280110
24Gingivitis (HP:0000230)3.87737797
25Encephalitis (HP:0002383)3.85379767
26Urticaria (HP:0001025)3.64560911
27Chest pain (HP:0100749)3.51070384
28Chronic mucocutaneous candidiasis (HP:0002728)3.50850119
29Recurrent cutaneous fungal infections (HP:0011370)3.50850119
30Peritonitis (HP:0002586)3.49697471
31Vasculitis (HP:0002633)3.49027744
32Increased IgE level (HP:0003212)3.43846049
33T lymphocytopenia (HP:0005403)3.41842696
34Hypochromic anemia (HP:0001931)3.36258964
35Abnormality of T cell number (HP:0011839)3.26320228
36Hemoptysis (HP:0002105)3.26120254
37Gingival bleeding (HP:0000225)3.24716573
38Prolonged bleeding time (HP:0003010)3.22335851
39Pulmonary infiltrates (HP:0002113)3.21154031
40Episodic fever (HP:0001954)3.18590097
41Arterial thrombosis (HP:0004420)3.12514401
42Cellulitis (HP:0100658)3.09034114
43Anorexia (HP:0002039)2.94769665
44Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.93632618
45Leukocytosis (HP:0001974)2.89893103
46Pulmonary embolism (HP:0002204)2.85180666
47Abnormality of T cells (HP:0002843)2.75222723
48Amyloidosis (HP:0011034)2.72843371
49Epistaxis (HP:0000421)2.72343407
50Microcytic anemia (HP:0001935)2.62530382
51Gangrene (HP:0100758)2.60153049
52Inflammation of the large intestine (HP:0002037)2.53921941
53Abnormality of the pleura (HP:0002103)2.48837375
54Osteomyelitis (HP:0002754)2.46295399
55Abnormality of the peritoneum (HP:0002585)2.42507002
56Gastrointestinal inflammation (HP:0004386)2.42122262
57Sepsis (HP:0100806)2.42106536
58Recurrent viral infections (HP:0004429)2.42105659
59Increased IgM level (HP:0003496)2.38559571
60Granulocytopenia (HP:0001913)2.38141756
61Pustule (HP:0200039)2.33183065
62Slow saccadic eye movements (HP:0000514)2.28566767
63Abnormality of the endocardium (HP:0004306)2.27377649
64Petechiae (HP:0000967)2.25608201
65Abnormality of T cell physiology (HP:0011840)2.23063987
66Subacute progressive viral hepatitis (HP:0006572)2.20530256
67Glomerulopathy (HP:0100820)2.20486170
68Keratitis (HP:0000491)2.13305819
69Vertigo (HP:0002321)2.11215862
70Eosinophilia (HP:0001880)2.09567344
71Neoplasm of the tracheobronchial system (HP:0100552)2.09082822
72Acne (HP:0001061)2.09081452
73Abnormality of the pericardium (HP:0001697)2.08858819
74Lymphopenia (HP:0001888)2.08731367
75Abnormal platelet volume (HP:0011876)2.07990776
76Hypergammaglobulinemia (HP:0010702)2.05436687
77Panhypogammaglobulinemia (HP:0003139)2.05202393
78Skin ulcer (HP:0200042)1.99559423
79Alveolar cell carcinoma (HP:0006519)1.99422615
80Acute hepatic failure (HP:0006554)1.97959280
81Abnormality of cells of the lymphoid lineage (HP:0012140)1.96913125
82Viral hepatitis (HP:0006562)1.94623090
83Segmental peripheral demyelination/remyelination (HP:0003481)1.92840311
84Premature loss of primary teeth (HP:0006323)1.89889012
85Cheilitis (HP:0100825)1.84378938
86Recurrent pneumonia (HP:0006532)1.84247492
87Toxemia of pregnancy (HP:0100603)1.83528198
88Purpura (HP:0000979)1.82500151
89Polycythemia (HP:0001901)1.81675342
90Polyneuropathy (HP:0001271)1.81453567
91Increased serum ferritin (HP:0003281)1.81310039
92Thrombophlebitis (HP:0004418)1.80663158
93Difficulty running (HP:0009046)1.79477566
94Abnormality of the heme biosynthetic pathway (HP:0010472)1.78877634
95Recurrent bronchitis (HP:0002837)1.78807604
96Hepatosplenomegaly (HP:0001433)1.78151946
97Abnormality of eosinophils (HP:0001879)1.77564735
98Abnormality of iron homeostasis (HP:0011031)1.77393556
99Skin rash (HP:0000988)1.75639689
100Hypermelanotic macule (HP:0001034)1.75346205

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK45.01650913
2IRAK43.55530414
3BLK3.48028715
4MAP4K13.14109909
5MAP2K33.07990833
6CSK2.96649037
7TYK22.64316943
8ERN12.58630947
9FES2.41404067
10EPHB12.40806929
11GRK62.40605713
12TNK22.10023354
13ZAP702.02174528
14TAOK11.91106514
15FGR1.87720129
16TXK1.86377137
17MAP3K31.86276008
18JAK31.83679781
19HCK1.77924729
20BTK1.72235065
21PRPF4B1.67563853
22KSR21.61646689
23SYK1.60234797
24MAP3K141.57756592
25JAK21.54410087
26MAP3K111.51843038
27YES11.51716888
28TAOK31.49479015
29IKBKE1.47283620
30MAP3K11.42635997
31IRAK11.38024995
32LYN1.36139625
33IRAK21.25873858
34MAP3K21.24304344
35JAK11.20411164
36SIK31.18135937
37MATK1.17729140
38MAP3K131.08333169
39TBK11.07354575
40LCK1.06406062
41ITK1.05498816
42PTK61.01778466
43MARK30.99033689
44MARK20.98983217
45CSF1R0.95779375
46CDK190.93456564
47BMPR20.89689404
48MAP3K50.86409638
49MAP3K60.85412097
50KIT0.84377631
51PDK10.84151224
52MAP2K40.84058016
53TEC0.83659932
54LRRK20.82418657
55PIK3CG0.82266907
56PTK2B0.81970183
57STK100.81158814
58PRKD20.77709816
59TAOK20.76345669
60PDPK10.73372294
61SGK30.72262522
62IKBKB0.71193443
63TGFBR20.70120502
64RAF10.69524205
65FYN0.68812605
66STK110.68168068
67FGFR30.65965654
68EPHA30.65962962
69KSR10.65107463
70SIK20.64699483
71WNK10.62996716
72DYRK1B0.62269581
73STK380.60339284
74MAP3K70.57050744
75SGK20.56946314
76TESK20.56727581
77NLK0.54533868
78DAPK20.52824443
79MAPK120.52382184
80TRIB30.52283435
81RET0.48000956
82PRKCQ0.47016237
83PIM10.46693150
84FGFR40.46344292
85SMG10.45604478
86RPS6KL10.44138281
87RPS6KC10.44138281
88DYRK30.43936266
89MAPK70.43124638
90HIPK20.41744245
91MAP2K60.41527592
92PRKCZ0.41155809
93RPS6KA60.39831918
94STK240.38973392
95MAPKAPK20.38956724
96CDC42BPA0.36605418
97PRKG20.36065658
98CAMK40.34112322
99CAMKK10.33412541
100GRK70.28774664

Predicted pathways (KEGG)

RankGene SetZ-score
1Osteoclast differentiation_Homo sapiens_hsa043803.08980577
2Leishmaniasis_Homo sapiens_hsa051403.08499574
3Staphylococcus aureus infection_Homo sapiens_hsa051502.82979564
4Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.43405887
5Tuberculosis_Homo sapiens_hsa051522.28008498
6B cell receptor signaling pathway_Homo sapiens_hsa046622.27572941
7Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046662.27318110
8Toll-like receptor signaling pathway_Homo sapiens_hsa046202.11631457
9Malaria_Homo sapiens_hsa051442.04291176
10Graft-versus-host disease_Homo sapiens_hsa053322.03010389
11NOD-like receptor signaling pathway_Homo sapiens_hsa046212.00606745
12Allograft rejection_Homo sapiens_hsa053301.91706368
13Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.82245923
14Chemokine signaling pathway_Homo sapiens_hsa040621.82195431
15Autoimmune thyroid disease_Homo sapiens_hsa053201.79407785
16Measles_Homo sapiens_hsa051621.77839326
17Acute myeloid leukemia_Homo sapiens_hsa052211.70948093
18Primary immunodeficiency_Homo sapiens_hsa053401.70900710
19Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.67139079
20Legionellosis_Homo sapiens_hsa051341.66181509
21T cell receptor signaling pathway_Homo sapiens_hsa046601.62746556
22NF-kappa B signaling pathway_Homo sapiens_hsa040641.56729831
23Hematopoietic cell lineage_Homo sapiens_hsa046401.53972116
24Toxoplasmosis_Homo sapiens_hsa051451.50802132
25Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.43655281
26Phagosome_Homo sapiens_hsa041451.43090961
27Influenza A_Homo sapiens_hsa051641.42705916
28Type I diabetes mellitus_Homo sapiens_hsa049401.42136107
29Jak-STAT signaling pathway_Homo sapiens_hsa046301.41593374
30Non-small cell lung cancer_Homo sapiens_hsa052231.40292428
31Antigen processing and presentation_Homo sapiens_hsa046121.36522508
32Leukocyte transendothelial migration_Homo sapiens_hsa046701.32935399
33African trypanosomiasis_Homo sapiens_hsa051431.32023309
34RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.30703568
35TNF signaling pathway_Homo sapiens_hsa046681.28948381
36Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.26574527
37Viral myocarditis_Homo sapiens_hsa054161.25913189
38Platelet activation_Homo sapiens_hsa046111.20697503
39Herpes simplex infection_Homo sapiens_hsa051681.19734017
40Hepatitis B_Homo sapiens_hsa051611.19183798
41Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.12295724
42Pancreatic cancer_Homo sapiens_hsa052121.09802690
43Hepatitis C_Homo sapiens_hsa051601.08336406
44Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.05975754
45Chronic myeloid leukemia_Homo sapiens_hsa052201.01593013
46Salmonella infection_Homo sapiens_hsa051321.01517994
47VEGF signaling pathway_Homo sapiens_hsa043700.98553026
48Pertussis_Homo sapiens_hsa051330.97669647
49Apoptosis_Homo sapiens_hsa042100.97053639
50Renal cell carcinoma_Homo sapiens_hsa052110.97028486
51Shigellosis_Homo sapiens_hsa051310.94093080
52Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.91229088
53Prolactin signaling pathway_Homo sapiens_hsa049170.90730384
54Neurotrophin signaling pathway_Homo sapiens_hsa047220.89230654
55Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.88653629
56Notch signaling pathway_Homo sapiens_hsa043300.86373965
57Intestinal immune network for IgA production_Homo sapiens_hsa046720.85933215
58Dorso-ventral axis formation_Homo sapiens_hsa043200.83870337
59Endocytosis_Homo sapiens_hsa041440.82532367
60FoxO signaling pathway_Homo sapiens_hsa040680.82527040
61Rheumatoid arthritis_Homo sapiens_hsa053230.80849640
62Carbohydrate digestion and absorption_Homo sapiens_hsa049730.78786072
63Endometrial cancer_Homo sapiens_hsa052130.78185376
64Sphingolipid signaling pathway_Homo sapiens_hsa040710.76737276
65AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.75734814
66Phospholipase D signaling pathway_Homo sapiens_hsa040720.75201873
67Asthma_Homo sapiens_hsa053100.73357207
68Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.72159896
69Phosphatidylinositol signaling system_Homo sapiens_hsa040700.69703971
70Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.68575115
71Choline metabolism in cancer_Homo sapiens_hsa052310.67946667
72Adipocytokine signaling pathway_Homo sapiens_hsa049200.67750186
73Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.67631774
74Amoebiasis_Homo sapiens_hsa051460.66039557
75SNARE interactions in vesicular transport_Homo sapiens_hsa041300.65694995
76GnRH signaling pathway_Homo sapiens_hsa049120.65183369
77Other glycan degradation_Homo sapiens_hsa005110.64232360
78Regulation of autophagy_Homo sapiens_hsa041400.63447753
79mTOR signaling pathway_Homo sapiens_hsa041500.62154281
80Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.61890001
81Viral carcinogenesis_Homo sapiens_hsa052030.61861676
82Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.61676268
83Lysosome_Homo sapiens_hsa041420.60598677
84HIF-1 signaling pathway_Homo sapiens_hsa040660.59864150
85Colorectal cancer_Homo sapiens_hsa052100.57568829
86Inositol phosphate metabolism_Homo sapiens_hsa005620.56475621
87Epstein-Barr virus infection_Homo sapiens_hsa051690.54788636
88Rap1 signaling pathway_Homo sapiens_hsa040150.53506897
89MAPK signaling pathway_Homo sapiens_hsa040100.52050814
90Insulin resistance_Homo sapiens_hsa049310.52050583
91ErbB signaling pathway_Homo sapiens_hsa040120.51753939
92Type II diabetes mellitus_Homo sapiens_hsa049300.50502168
93Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.50190824
94Glycerophospholipid metabolism_Homo sapiens_hsa005640.46631076
95Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.46305008
96Prostate cancer_Homo sapiens_hsa052150.45363732
97HTLV-I infection_Homo sapiens_hsa051660.40937123
98Glioma_Homo sapiens_hsa052140.40893617
99Estrogen signaling pathway_Homo sapiens_hsa049150.39805709
100Regulation of actin cytoskeleton_Homo sapiens_hsa048100.39112591

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