ADGRD2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)5.44486758
2fucose catabolic process (GO:0019317)5.00399783
3L-fucose metabolic process (GO:0042354)5.00399783
4L-fucose catabolic process (GO:0042355)5.00399783
5DNA deamination (GO:0045006)4.18870281
6indole-containing compound catabolic process (GO:0042436)4.18606745
7indolalkylamine catabolic process (GO:0046218)4.18606745
8tryptophan catabolic process (GO:0006569)4.18606745
9indolalkylamine metabolic process (GO:0006586)4.10701742
10kynurenine metabolic process (GO:0070189)4.06966839
11response to pheromone (GO:0019236)3.86591065
12negative regulation of telomere maintenance (GO:0032205)3.74542800
13epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.61927194
14detection of light stimulus involved in sensory perception (GO:0050962)3.58360726
15detection of light stimulus involved in visual perception (GO:0050908)3.58360726
16tryptophan metabolic process (GO:0006568)3.53924064
17detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.51972356
18platelet dense granule organization (GO:0060155)3.48679959
19cellular ketone body metabolic process (GO:0046950)3.45500178
20cellular response to ATP (GO:0071318)3.40310035
21water-soluble vitamin biosynthetic process (GO:0042364)3.24894920
22axoneme assembly (GO:0035082)3.20051577
23preassembly of GPI anchor in ER membrane (GO:0016254)3.18182954
24cornea development in camera-type eye (GO:0061303)3.11543636
25ketone body metabolic process (GO:1902224)3.10874811
26rRNA catabolic process (GO:0016075)3.07505086
27protein polyglutamylation (GO:0018095)3.05642772
28kidney morphogenesis (GO:0060993)3.05561045
29indole-containing compound metabolic process (GO:0042430)3.02228782
30protein K11-linked deubiquitination (GO:0035871)3.00300618
31neural tube formation (GO:0001841)2.97930550
32protein localization to cilium (GO:0061512)2.97834617
33G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.96354354
34positive regulation of defense response to virus by host (GO:0002230)2.94401061
35epithelial cilium movement (GO:0003351)2.91344118
36negative regulation of mast cell activation (GO:0033004)2.89670638
37nephron epithelium morphogenesis (GO:0072088)2.87364644
38nephron tubule morphogenesis (GO:0072078)2.87364644
39reflex (GO:0060004)2.86777372
40nonmotile primary cilium assembly (GO:0035058)2.86407711
41mannosylation (GO:0097502)2.85633846
42auditory receptor cell stereocilium organization (GO:0060088)2.82438667
43primary amino compound metabolic process (GO:1901160)2.80308520
44retinal cone cell development (GO:0046549)2.79563049
45mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.73139308
46mitochondrial respiratory chain complex I assembly (GO:0032981)2.73139308
47NADH dehydrogenase complex assembly (GO:0010257)2.73139308
48piRNA metabolic process (GO:0034587)2.70216673
49regulation of telomere maintenance (GO:0032204)2.70091788
50photoreceptor cell development (GO:0042461)2.67996784
51protein complex biogenesis (GO:0070271)2.67988156
52cilium morphogenesis (GO:0060271)2.67211638
53amine catabolic process (GO:0009310)2.66698116
54cellular biogenic amine catabolic process (GO:0042402)2.66698116
55negative regulation of translation, ncRNA-mediated (GO:0040033)2.66212632
56regulation of translation, ncRNA-mediated (GO:0045974)2.66212632
57negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.66212632
58neuronal action potential (GO:0019228)2.65841155
59respiratory chain complex IV assembly (GO:0008535)2.65521131
60L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.63772782
61sulfation (GO:0051923)2.63436017
62benzene-containing compound metabolic process (GO:0042537)2.60547138
63gamma-aminobutyric acid transport (GO:0015812)2.57270049
64positive regulation of oligodendrocyte differentiation (GO:0048714)2.57211921
65somite development (GO:0061053)2.56666745
66cAMP catabolic process (GO:0006198)2.55346791
67negative regulation of synaptic transmission, GABAergic (GO:0032229)2.54768271
68cilium organization (GO:0044782)2.54411564
69photoreceptor cell maintenance (GO:0045494)2.53519104
70regulation of nuclear cell cycle DNA replication (GO:0033262)2.53294783
71proline transport (GO:0015824)2.53266655
72cilium movement (GO:0003341)2.52644582
73phosphatidylinositol acyl-chain remodeling (GO:0036149)2.50577610
74regulation of rhodopsin mediated signaling pathway (GO:0022400)2.50373480
75serotonin metabolic process (GO:0042428)2.50297723
76positive regulation of fatty acid transport (GO:2000193)2.50288712
77recombinational repair (GO:0000725)2.49846501
78DNA demethylation (GO:0080111)2.49502784
79inner ear receptor stereocilium organization (GO:0060122)2.49080967
80double-strand break repair via homologous recombination (GO:0000724)2.48617425
81rhodopsin mediated signaling pathway (GO:0016056)2.48313290
82cytidine catabolic process (GO:0006216)2.47896989
83cytidine deamination (GO:0009972)2.47896989
84cytidine metabolic process (GO:0046087)2.47896989
85mitochondrial respiratory chain complex assembly (GO:0033108)2.47854794
86negative regulation of cytosolic calcium ion concentration (GO:0051481)2.47035375
87regulation of hippo signaling (GO:0035330)2.46904549
88cilium assembly (GO:0042384)2.45180372
89negative regulation of reactive oxygen species metabolic process (GO:2000378)2.44937161
90reciprocal meiotic recombination (GO:0007131)2.44869561
91reciprocal DNA recombination (GO:0035825)2.44869561
92cilium or flagellum-dependent cell motility (GO:0001539)2.42188306
93L-methionine salvage (GO:0071267)2.42068778
94L-methionine biosynthetic process (GO:0071265)2.42068778
95amino acid salvage (GO:0043102)2.42068778
96fucosylation (GO:0036065)2.40810597
97DNA methylation involved in gamete generation (GO:0043046)2.39979222
98head development (GO:0060322)2.39809459
99regulation of cilium movement (GO:0003352)2.39418273
100replication fork processing (GO:0031297)2.39398348

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela4.22055792
2VDR_22108803_ChIP-Seq_LS180_Human3.60064413
3GBX2_23144817_ChIP-Seq_PC3_Human2.99683211
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.78557782
5EZH2_22144423_ChIP-Seq_EOC_Human2.73450724
6GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.53179473
7ZFP57_27257070_Chip-Seq_ESCs_Mouse2.51002579
8IGF1R_20145208_ChIP-Seq_DFB_Human2.37199242
9CTBP2_25329375_ChIP-Seq_LNCAP_Human2.22469199
10POU3F2_20337985_ChIP-ChIP_501MEL_Human2.22307144
11FLI1_27457419_Chip-Seq_LIVER_Mouse2.15190179
12EWS_26573619_Chip-Seq_HEK293_Human2.05622042
13CTBP1_25329375_ChIP-Seq_LNCAP_Human2.01759717
14FUS_26573619_Chip-Seq_HEK293_Human2.01554926
15HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.99598870
16P300_19829295_ChIP-Seq_ESCs_Human1.95476729
17ER_23166858_ChIP-Seq_MCF-7_Human1.95053227
18FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.91737851
19TAF15_26573619_Chip-Seq_HEK293_Human1.84695161
20EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.80163951
21NOTCH1_21737748_ChIP-Seq_TLL_Human1.76172682
22MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.74117471
23PCGF2_27294783_Chip-Seq_ESCs_Mouse1.69554938
24TP53_22573176_ChIP-Seq_HFKS_Human1.67100056
25HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.63601987
26MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.62499633
27CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.59144207
28IRF1_19129219_ChIP-ChIP_H3396_Human1.58910450
29STAT3_23295773_ChIP-Seq_U87_Human1.58337932
30UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.56829303
31CBP_20019798_ChIP-Seq_JUKART_Human1.54879896
32IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.54879896
33BCAT_22108803_ChIP-Seq_LS180_Human1.54573923
34AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.50104290
35SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.49765005
36TCF4_23295773_ChIP-Seq_U87_Human1.48708053
37SMAD4_21799915_ChIP-Seq_A2780_Human1.45178189
38TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.44395158
39POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.44395158
40MYC_18940864_ChIP-ChIP_HL60_Human1.44310925
41PIAS1_25552417_ChIP-Seq_VCAP_Human1.42603361
42PCGF2_27294783_Chip-Seq_NPCs_Mouse1.41682296
43REST_21632747_ChIP-Seq_MESCs_Mouse1.41118716
44AR_25329375_ChIP-Seq_VCAP_Human1.39535317
45RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.38715502
46TCF4_22108803_ChIP-Seq_LS180_Human1.38272006
47SALL1_21062744_ChIP-ChIP_HESCs_Human1.37543890
48SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.36166017
49NR3C1_21868756_ChIP-Seq_MCF10A_Human1.35359705
50NANOG_19829295_ChIP-Seq_ESCs_Human1.33403190
51SOX2_19829295_ChIP-Seq_ESCs_Human1.33403190
52SUZ12_27294783_Chip-Seq_NPCs_Mouse1.32488735
53PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.31447970
54BMI1_23680149_ChIP-Seq_NPCS_Mouse1.30671413
55GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.28227566
56TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.28073792
57FOXA1_27270436_Chip-Seq_PROSTATE_Human1.27530394
58FOXA1_25329375_ChIP-Seq_VCAP_Human1.27530394
59ETV2_25802403_ChIP-Seq_MESCs_Mouse1.25505650
60AR_21572438_ChIP-Seq_LNCaP_Human1.24589894
61SMAD3_21741376_ChIP-Seq_EPCs_Human1.24151328
62GATA3_21878914_ChIP-Seq_MCF-7_Human1.23208875
63MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.22485019
64GABP_17652178_ChIP-ChIP_JURKAT_Human1.22314846
65NFE2_27457419_Chip-Seq_LIVER_Mouse1.21333903
66RUNX2_22187159_ChIP-Seq_PCA_Human1.21275965
67TOP2B_26459242_ChIP-Seq_MCF-7_Human1.20748595
68NCOR_22424771_ChIP-Seq_293T_Human1.20550499
69CBX2_27304074_Chip-Seq_ESCs_Mouse1.20378801
70HOXB7_26014856_ChIP-Seq_BT474_Human1.20204506
71KLF5_20875108_ChIP-Seq_MESCs_Mouse1.18589782
72NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.18204722
73AR_20517297_ChIP-Seq_VCAP_Human1.18191537
74PRDM14_20953172_ChIP-Seq_ESCs_Human1.16696824
75EZH2_27294783_Chip-Seq_NPCs_Mouse1.16085264
76SMAD4_21741376_ChIP-Seq_EPCs_Human1.14423761
77EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.12873601
78FOXA1_21572438_ChIP-Seq_LNCaP_Human1.11757334
79FLI1_21867929_ChIP-Seq_TH2_Mouse1.11487441
80RNF2_27304074_Chip-Seq_NSC_Mouse1.06280722
81E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.05339083
82DROSHA_22980978_ChIP-Seq_HELA_Human1.03851792
83SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.02680222
84CRX_20693478_ChIP-Seq_RETINA_Mouse1.02213407
85AUTS2_25519132_ChIP-Seq_293T-REX_Human1.00920128
86ERA_21632823_ChIP-Seq_H3396_Human1.00452487
87CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.00315139
88OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.99149314
89KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.99062680
90TP53_16413492_ChIP-PET_HCT116_Human0.98462914
91EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.98018960
92EST1_17652178_ChIP-ChIP_JURKAT_Human0.97328029
93CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.97268307
94REST_18959480_ChIP-ChIP_MESCs_Mouse0.97196984
95NANOG_18555785_Chip-Seq_ESCs_Mouse0.96760111
96MYC_19829295_ChIP-Seq_ESCs_Human0.96000298
97CDX2_22108803_ChIP-Seq_LS180_Human0.95599527
98EGR1_23403033_ChIP-Seq_LIVER_Mouse0.94837070
99PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.94341936
100VDR_23849224_ChIP-Seq_CD4+_Human0.93779827

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003195_calcinosis2.96282403
2MP0002102_abnormal_ear_morphology2.76420542
3MP0000569_abnormal_digit_pigmentation2.76340786
4MP0005551_abnormal_eye_electrophysiolog2.64978853
5MP0008877_abnormal_DNA_methylation2.57782258
6MP0006072_abnormal_retinal_apoptosis2.42279874
7MP0001968_abnormal_touch/_nociception2.32913138
8MP0004147_increased_porphyrin_level2.23798306
9MP0001501_abnormal_sleep_pattern2.18904720
10MP0008872_abnormal_physiological_respon2.13663485
11MP0003646_muscle_fatigue2.07665339
12MP0002837_dystrophic_cardiac_calcinosis2.05118649
13MP0005253_abnormal_eye_physiology2.01628760
14MP0004043_abnormal_pH_regulation1.99590448
15MP0004885_abnormal_endolymph1.96096413
16MP0009745_abnormal_behavioral_response1.93781162
17MP0001986_abnormal_taste_sensitivity1.92591896
18MP0002736_abnormal_nociception_after1.88510618
19MP0000427_abnormal_hair_cycle1.86967258
20MP0008875_abnormal_xenobiotic_pharmacok1.85946378
21MP0002876_abnormal_thyroid_physiology1.85486248
22MP0009046_muscle_twitch1.84633153
23MP0005645_abnormal_hypothalamus_physiol1.80505322
24MP0004142_abnormal_muscle_tone1.76894238
25MP0003787_abnormal_imprinting1.76365153
26MP0005646_abnormal_pituitary_gland1.73857283
27MP0006276_abnormal_autonomic_nervous1.66705101
28MP0002653_abnormal_ependyma_morphology1.66524735
29MP0000372_irregular_coat_pigmentation1.64226298
30MP0006292_abnormal_olfactory_placode1.61711555
31MP0003011_delayed_dark_adaptation1.61275794
32MP0005174_abnormal_tail_pigmentation1.59099405
33MP0005167_abnormal_blood-brain_barrier1.55893245
34MP0002272_abnormal_nervous_system1.55404080
35MP0004133_heterotaxia1.54404926
36MP0002638_abnormal_pupillary_reflex1.49738559
37MP0003136_yellow_coat_color1.47792795
38MP0004145_abnormal_muscle_electrophysio1.46872593
39MP0001486_abnormal_startle_reflex1.42732963
40MP0002938_white_spotting1.40863236
41MP0003880_abnormal_central_pattern1.40004262
42MP0002234_abnormal_pharynx_morphology1.39645849
43MP0000631_abnormal_neuroendocrine_gland1.38068165
44MP0005084_abnormal_gallbladder_morpholo1.37933281
45MP0002735_abnormal_chemical_nociception1.36052446
46MP0002733_abnormal_thermal_nociception1.34755123
47MP0002557_abnormal_social/conspecific_i1.33416870
48MP0002572_abnormal_emotion/affect_behav1.32053813
49MP0001984_abnormal_olfaction1.31916892
50MP0001485_abnormal_pinna_reflex1.29444062
51MP0004742_abnormal_vestibular_system1.28445264
52MP0002928_abnormal_bile_duct1.28206008
53MP0001970_abnormal_pain_threshold1.27769372
54MP0000383_abnormal_hair_follicle1.26711736
55MP0003283_abnormal_digestive_organ1.25069824
56MP0008995_early_reproductive_senescence1.21126728
57MP0005377_hearing/vestibular/ear_phenot1.21118966
58MP0003878_abnormal_ear_physiology1.21118966
59MP0004924_abnormal_behavior1.15612713
60MP0005386_behavior/neurological_phenoty1.15612713
61MP0002064_seizures1.12988105
62MP0005389_reproductive_system_phenotype1.11124786
63MP0001529_abnormal_vocalization1.09441205
64MP0001919_abnormal_reproductive_system1.05691529
65MP0005195_abnormal_posterior_eye1.03390058
66MP0002163_abnormal_gland_morphology1.02501593
67MP0005379_endocrine/exocrine_gland_phen1.00986065
68MP0004215_abnormal_myocardial_fiber1.00425778
69MP0002067_abnormal_sensory_capabilities1.00237183
70MP0002095_abnormal_skin_pigmentation0.99604819
71MP0005332_abnormal_amino_acid0.99149963
72MP0003718_maternal_effect0.98053216
73MP0002063_abnormal_learning/memory/cond0.97485095
74MP0002160_abnormal_reproductive_system0.95089682
75MP0000230_abnormal_systemic_arterial0.93554815
76MP0008775_abnormal_heart_ventricle0.93390814
77MP0001502_abnormal_circadian_rhythm0.91918718
78MP0003890_abnormal_embryonic-extraembry0.91593936
79MP0003635_abnormal_synaptic_transmissio0.91322027
80MP0005075_abnormal_melanosome_morpholog0.90627553
81MP0001905_abnormal_dopamine_level0.90395539
82MP0005171_absent_coat_pigmentation0.90133623
83MP0002138_abnormal_hepatobiliary_system0.89444467
84MP0005410_abnormal_fertilization0.88890250
85MP0010329_abnormal_lipoprotein_level0.87388825
86MP0003137_abnormal_impulse_conducting0.87216703
87MP0002734_abnormal_mechanical_nocicepti0.86995522
88MP0002752_abnormal_somatic_nervous0.85917505
89MP0002751_abnormal_autonomic_nervous0.85460841
90MP0000026_abnormal_inner_ear0.84617742
91MP0001764_abnormal_homeostasis0.83409025
92MP0001963_abnormal_hearing_physiology0.80031849
93MP0003119_abnormal_digestive_system0.78890900
94MP0002229_neurodegeneration0.78381423
95MP0000647_abnormal_sebaceous_gland0.77272744
96MP0002184_abnormal_innervation0.77012463
97MP0005671_abnormal_response_to0.75955540
98MP0002693_abnormal_pancreas_physiology0.75521965
99MP0002909_abnormal_adrenal_gland0.74893393
100MP0004085_abnormal_heartbeat0.74795571

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)4.63453333
2Congenital stationary night blindness (HP:0007642)4.26948248
3Pancreatic fibrosis (HP:0100732)4.18658468
4Abnormality of midbrain morphology (HP:0002418)4.05903259
5Molar tooth sign on MRI (HP:0002419)4.05903259
6True hermaphroditism (HP:0010459)3.99936256
7Nephronophthisis (HP:0000090)3.64156055
8Abnormality of the renal cortex (HP:0011035)3.44937080
9Abnormality of the renal medulla (HP:0100957)3.28376555
10Hyperventilation (HP:0002883)3.22051506
11Chronic hepatic failure (HP:0100626)3.11162063
12Attenuation of retinal blood vessels (HP:0007843)3.02803277
13Type II lissencephaly (HP:0007260)3.00506681
14Abnormal drinking behavior (HP:0030082)2.97665397
15Polydipsia (HP:0001959)2.97665397
16Cystic liver disease (HP:0006706)2.93731995
17Tubular atrophy (HP:0000092)2.87627261
18Abnormal rod and cone electroretinograms (HP:0008323)2.80928031
19Medial flaring of the eyebrow (HP:0010747)2.77721812
20Genetic anticipation (HP:0003743)2.73225288
21Pendular nystagmus (HP:0012043)2.68767830
22Large for gestational age (HP:0001520)2.67081674
23Abolished electroretinogram (ERG) (HP:0000550)2.65367649
24Absent rod-and cone-mediated responses on ERG (HP:0007688)2.64875036
25Abnormal biliary tract physiology (HP:0012439)2.63998192
26Bile duct proliferation (HP:0001408)2.63998192
27Polyuria (HP:0000103)2.54940010
28Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.53264255
29Abnormality of alanine metabolism (HP:0010916)2.53264255
30Hyperalaninemia (HP:0003348)2.53264255
31Inability to walk (HP:0002540)2.52242979
32Abnormality of the pons (HP:0007361)2.52012234
33Hypoplasia of the pons (HP:0012110)2.51625228
34Progressive inability to walk (HP:0002505)2.48761072
35Progressive cerebellar ataxia (HP:0002073)2.38494359
36Sclerocornea (HP:0000647)2.37763905
37Congenital, generalized hypertrichosis (HP:0004540)2.34250709
38Decreased central vision (HP:0007663)2.33927884
39Gaze-evoked nystagmus (HP:0000640)2.32074343
40Increased corneal curvature (HP:0100692)2.30640783
41Keratoconus (HP:0000563)2.30640783
42Lissencephaly (HP:0001339)2.28390410
43Renal cortical cysts (HP:0000803)2.25429075
44Decreased circulating renin level (HP:0003351)2.25262464
45Methylmalonic acidemia (HP:0002912)2.17682023
46Congenital hepatic fibrosis (HP:0002612)2.14516817
47Gait imbalance (HP:0002141)2.14078455
48Methylmalonic aciduria (HP:0012120)2.12213092
49Bony spicule pigmentary retinopathy (HP:0007737)2.10577663
50Hemiparesis (HP:0001269)2.10245011
51Hypomagnesemia (HP:0002917)2.10142120
52Congenital primary aphakia (HP:0007707)2.08644924
53Abnormality of the renal collecting system (HP:0004742)2.06779680
54Aplasia/Hypoplasia of the tongue (HP:0010295)2.06757224
55Broad-based gait (HP:0002136)2.06453580
56Stomach cancer (HP:0012126)2.06225900
57Nephrogenic diabetes insipidus (HP:0009806)2.06048567
58Furrowed tongue (HP:0000221)2.05808599
59Cerebellar dysplasia (HP:0007033)2.05714957
60Protruding tongue (HP:0010808)2.05386894
61Anencephaly (HP:0002323)2.03677725
62Abnormal urine output (HP:0012590)2.00939058
63Ketosis (HP:0001946)2.00826138
64Clumsiness (HP:0002312)2.00199685
65Hypothermia (HP:0002045)1.96329977
66Tachypnea (HP:0002789)1.95868364
67Decreased electroretinogram (ERG) amplitude (HP:0000654)1.95630677
68Patellar aplasia (HP:0006443)1.95618022
69Febrile seizures (HP:0002373)1.93641926
70Severe muscular hypotonia (HP:0006829)1.93492074
71Occipital encephalocele (HP:0002085)1.91980779
72Aplasia/Hypoplasia of the tibia (HP:0005772)1.90797724
73Pachygyria (HP:0001302)1.90748240
74Duplicated collecting system (HP:0000081)1.89424714
75Aplasia/Hypoplasia of the patella (HP:0006498)1.88964584
76Acute necrotizing encephalopathy (HP:0006965)1.88865560
77Intestinal atresia (HP:0011100)1.88740985
783-Methylglutaconic aciduria (HP:0003535)1.87796061
79Male pseudohermaphroditism (HP:0000037)1.87070903
80Postaxial foot polydactyly (HP:0001830)1.84914546
81Increased CSF lactate (HP:0002490)1.84603283
82Ketoacidosis (HP:0001993)1.84093249
83Dynein arm defect of respiratory motile cilia (HP:0012255)1.83141412
84Absent/shortened dynein arms (HP:0200106)1.83141412
85Absent speech (HP:0001344)1.83078475
86Mitochondrial inheritance (HP:0001427)1.80471004
87Chorioretinal atrophy (HP:0000533)1.79417798
88Congenital sensorineural hearing impairment (HP:0008527)1.78408303
89Aplasia/Hypoplasia of the spleen (HP:0010451)1.78377283
90Colon cancer (HP:0003003)1.75324874
91Optic disc pallor (HP:0000543)1.74944672
92Aplasia/Hypoplasia of the uvula (HP:0010293)1.74479132
93Abnormal respiratory epithelium morphology (HP:0012253)1.72470080
94Abnormal respiratory motile cilium morphology (HP:0005938)1.72470080
95Aplasia/Hypoplasia of the fovea (HP:0008060)1.72018532
96Hypoplasia of the fovea (HP:0007750)1.72018532
97Abnormality of renal excretion (HP:0011036)1.69374180
98Genital tract atresia (HP:0001827)1.68795882
99Acute encephalopathy (HP:0006846)1.67469150
100Progressive macrocephaly (HP:0004481)1.67054438

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.72574387
2INSRR3.23306524
3ADRBK23.20696710
4MAP4K22.87327181
5BMPR1B2.82277050
6GRK12.79231695
7ZAK2.59006284
8TLK12.57051000
9WNK42.45698854
10WNK32.32386922
11TAOK32.19563639
12PINK12.07569195
13NUAK12.04546966
14ACVR1B2.00814591
15CASK1.82410761
16MAP3K41.73883221
17MAPK131.67183958
18DAPK21.60893073
19BCKDK1.59771193
20OXSR11.58367452
21TXK1.51993778
22STK391.42132258
23MKNK21.26799746
24MAP2K61.24025379
25TIE11.16801409
26CAMKK21.16629198
27PAK31.14223400
28STK38L1.10462698
29NME11.07281114
30TRIM281.07129951
31MUSK1.06310146
32TNIK0.99749001
33ADRBK10.99332019
34MAP2K70.98801151
35EIF2AK30.98355859
36PRKCE0.96409674
37PNCK0.93786952
38TGFBR10.90856686
39MST40.88555562
40MARK10.87233035
41PRKCG0.86608434
42PIK3CA0.85978886
43NTRK30.85970024
44DYRK20.84262727
45IKBKB0.81215019
46AKT30.77366380
47VRK10.76969632
48PTK2B0.75914927
49MAPK150.75593317
50TEC0.74885139
51PHKG20.73246380
52PHKG10.73246380
53MAPKAPK50.72263072
54ERBB30.69084635
55MAPKAPK30.66424548
56TNK20.62748651
57FGFR20.62382377
58PLK20.60871262
59MKNK10.59832193
60CSNK1G20.59690258
61PRKCQ0.59408621
62FLT30.57602762
63CAMK10.57265770
64RPS6KA50.57029029
65ITK0.54583065
66CSNK1G10.54328663
67BRSK20.53223981
68KIT0.52492345
69TSSK60.49873182
70BCR0.49222435
71CSNK1A1L0.48948430
72OBSCN0.48556088
73PKN10.47379283
74CSNK1G30.46532096
75PRKAA20.46240344
76CHUK0.45314407
77CAMK1D0.45200070
78NLK0.44918598
79STK110.44501438
80FER0.44137193
81CAMK2A0.44031710
82PRKAA10.43725042
83IKBKE0.43202202
84ERBB20.42842832
85PRKACA0.42711232
86EPHA40.42675379
87EPHA30.42232638
88CAMK40.39989634
89CSNK1A10.39190779
90GRK70.38968214
91CAMK1G0.38302746
92PIK3CG0.36868892
93MAP2K20.36679468
94ATR0.36113561
95RPS6KA60.34608607
96PLK30.33053015
97PLK40.32321797
98SIK20.31896073
99PRKCA0.31542832
100PRKCH0.29856649

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047443.02099750
2Linoleic acid metabolism_Homo sapiens_hsa005912.75905606
3alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.71547529
4Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.63951241
5Nitrogen metabolism_Homo sapiens_hsa009102.52808624
6Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.35686012
7Butanoate metabolism_Homo sapiens_hsa006502.32684997
8Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.26632002
9Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.14852480
10Nicotine addiction_Homo sapiens_hsa050332.11865082
11Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.07620828
12Selenocompound metabolism_Homo sapiens_hsa004502.07384831
13Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.06763374
14Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.95764921
15Ether lipid metabolism_Homo sapiens_hsa005651.94733393
16Maturity onset diabetes of the young_Homo sapiens_hsa049501.93961017
17Tryptophan metabolism_Homo sapiens_hsa003801.91687963
18Oxidative phosphorylation_Homo sapiens_hsa001901.81160737
19Propanoate metabolism_Homo sapiens_hsa006401.78593476
20Protein export_Homo sapiens_hsa030601.77641832
21Homologous recombination_Homo sapiens_hsa034401.71257097
22Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.60867680
23Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.60809638
24Fanconi anemia pathway_Homo sapiens_hsa034601.60674465
25Taste transduction_Homo sapiens_hsa047421.58254535
26Caffeine metabolism_Homo sapiens_hsa002321.52960716
27Intestinal immune network for IgA production_Homo sapiens_hsa046721.47042687
28Morphine addiction_Homo sapiens_hsa050321.46174285
29RNA polymerase_Homo sapiens_hsa030201.43819455
30Basal transcription factors_Homo sapiens_hsa030221.41846383
31ABC transporters_Homo sapiens_hsa020101.30048964
32Parkinsons disease_Homo sapiens_hsa050121.28621868
33Primary bile acid biosynthesis_Homo sapiens_hsa001201.19859605
34Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.16495996
35One carbon pool by folate_Homo sapiens_hsa006701.15261485
36Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.15170501
37Olfactory transduction_Homo sapiens_hsa047401.14295367
38RNA degradation_Homo sapiens_hsa030181.11562964
39Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.09792690
40Chemical carcinogenesis_Homo sapiens_hsa052041.07836542
41Arachidonic acid metabolism_Homo sapiens_hsa005901.05932309
42Serotonergic synapse_Homo sapiens_hsa047261.04693472
43GABAergic synapse_Homo sapiens_hsa047271.03998217
44Steroid hormone biosynthesis_Homo sapiens_hsa001401.03805698
45Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.03762593
46Insulin secretion_Homo sapiens_hsa049111.01832516
47Peroxisome_Homo sapiens_hsa041461.01237925
48Circadian entrainment_Homo sapiens_hsa047130.99404161
49Regulation of autophagy_Homo sapiens_hsa041400.94558500
50Asthma_Homo sapiens_hsa053100.92953957
51Ovarian steroidogenesis_Homo sapiens_hsa049130.91925933
52Retinol metabolism_Homo sapiens_hsa008300.91429899
53Glutamatergic synapse_Homo sapiens_hsa047240.91147743
54Primary immunodeficiency_Homo sapiens_hsa053400.87787325
55Glycerolipid metabolism_Homo sapiens_hsa005610.80894521
56Huntingtons disease_Homo sapiens_hsa050160.80256097
57Cardiac muscle contraction_Homo sapiens_hsa042600.80184268
58Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.76969261
59Salivary secretion_Homo sapiens_hsa049700.75587133
60Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.75176828
61Alzheimers disease_Homo sapiens_hsa050100.74494668
62Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.74305634
63beta-Alanine metabolism_Homo sapiens_hsa004100.72513332
64Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.71775999
65Calcium signaling pathway_Homo sapiens_hsa040200.70817837
66Cyanoamino acid metabolism_Homo sapiens_hsa004600.68407907
67Type I diabetes mellitus_Homo sapiens_hsa049400.65823256
68Circadian rhythm_Homo sapiens_hsa047100.63687897
69Histidine metabolism_Homo sapiens_hsa003400.63348901
70Graft-versus-host disease_Homo sapiens_hsa053320.63150355
71Fat digestion and absorption_Homo sapiens_hsa049750.62381169
72Collecting duct acid secretion_Homo sapiens_hsa049660.62178982
73Sulfur metabolism_Homo sapiens_hsa009200.61120304
74Purine metabolism_Homo sapiens_hsa002300.57879395
75Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.57352120
76Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.57321038
77Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.56864322
78Metabolic pathways_Homo sapiens_hsa011000.56567584
79Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.54345853
80Dopaminergic synapse_Homo sapiens_hsa047280.53405440
81Autoimmune thyroid disease_Homo sapiens_hsa053200.52881667
82Allograft rejection_Homo sapiens_hsa053300.52599487
83Non-homologous end-joining_Homo sapiens_hsa034500.50852331
84Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.47186504
85Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.43876861
86Mineral absorption_Homo sapiens_hsa049780.43550837
87Dorso-ventral axis formation_Homo sapiens_hsa043200.43038139
88Sulfur relay system_Homo sapiens_hsa041220.42163424
89Pentose and glucuronate interconversions_Homo sapiens_hsa000400.41171831
90Long-term depression_Homo sapiens_hsa047300.41149268
91Vascular smooth muscle contraction_Homo sapiens_hsa042700.41000118
92Cocaine addiction_Homo sapiens_hsa050300.39055311
93Steroid biosynthesis_Homo sapiens_hsa001000.35134730
94Vitamin digestion and absorption_Homo sapiens_hsa049770.34689340
95cAMP signaling pathway_Homo sapiens_hsa040240.34077291
96Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.33649431
97Proteasome_Homo sapiens_hsa030500.31118007
98Cholinergic synapse_Homo sapiens_hsa047250.30724119
99Lysine degradation_Homo sapiens_hsa003100.30374504
100Rheumatoid arthritis_Homo sapiens_hsa053230.29238134

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »