ADGRD1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The adhesion G-protein-coupled receptors (GPCRs), including GPR133, are membrane-bound proteins with long N termini containing multiple domains. GPCRs, or GPRs, contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins (summary by Bjarnadottir et al., 2004 [PubMed 15203201]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein heterotrimerization (GO:0070208)7.11966961
2keratan sulfate catabolic process (GO:0042340)5.95291874
3collagen fibril organization (GO:0030199)5.71949009
4extracellular fibril organization (GO:0043206)5.26086993
5regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)5.24376125
6fibril organization (GO:0097435)4.88994901
7pericardium development (GO:0060039)4.71368980
8cardiac myofibril assembly (GO:0055003)4.68174049
9extracellular matrix assembly (GO:0085029)4.32552511
10cell migration involved in heart development (GO:0060973)4.24126557
11myofibril assembly (GO:0030239)4.24113568
12multicellular organismal macromolecule metabolic process (GO:0044259)4.23354084
13collagen metabolic process (GO:0032963)4.19876805
14multicellular organismal metabolic process (GO:0044236)4.12579725
15sequestering of extracellular ligand from receptor (GO:0035581)4.09228298
16negative regulation of cardiac muscle tissue growth (GO:0055022)4.04112201
17negative regulation of heart growth (GO:0061117)4.04112201
18collagen catabolic process (GO:0030574)4.04107795
19multicellular organismal catabolic process (GO:0044243)4.01881144
20type B pancreatic cell proliferation (GO:0044342)4.00059711
21low-density lipoprotein particle clearance (GO:0034383)3.98054974
22endocardial cushion development (GO:0003197)3.97494137
23regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.88659381
24negative regulation of complement activation (GO:0045916)3.83595436
25regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.63531233
26detection of molecule of bacterial origin (GO:0032490)3.61646738
27regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.54675165
28glomerular filtration (GO:0003094)3.51707571
29retina vasculature morphogenesis in camera-type eye (GO:0061299)3.50438547
30metanephric mesenchyme development (GO:0072075)3.49557623
31sarcomere organization (GO:0045214)3.48336893
32glomerular basement membrane development (GO:0032836)3.44236692
33extracellular matrix disassembly (GO:0022617)3.43649665
34skeletal muscle adaptation (GO:0043501)3.39125522
35basement membrane organization (GO:0071711)3.32183031
36bone trabecula formation (GO:0060346)3.30013687
37ovulation from ovarian follicle (GO:0001542)3.26866191
38positive regulation of natural killer cell differentiation (GO:0032825)3.23616078
39negative regulation of protein autophosphorylation (GO:0031953)3.21949843
40positive regulation of p38MAPK cascade (GO:1900745)3.21712854
41cellular response to vitamin (GO:0071295)3.21173972
42renal filtration (GO:0097205)3.20901818
43brown fat cell differentiation (GO:0050873)3.18837278
44mesenchymal cell differentiation involved in renal system development (GO:2001012)3.18180318
45mesenchymal cell differentiation involved in kidney development (GO:0072161)3.18180318
46regulation of the force of heart contraction (GO:0002026)3.17096341
47regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.16903612
48hemidesmosome assembly (GO:0031581)3.15959461
49opsonization (GO:0008228)3.14865574
50blood vessel maturation (GO:0001955)3.12386853
51white fat cell differentiation (GO:0050872)3.11769889
52mesenchymal-epithelial cell signaling (GO:0060638)3.07069431
53regulation of sequestering of triglyceride (GO:0010889)3.06290955
54apoptotic cell clearance (GO:0043277)3.03471738
55negative regulation of cardiac muscle hypertrophy (GO:0010614)3.03120826
56complement activation, alternative pathway (GO:0006957)3.02024205
57smooth muscle tissue development (GO:0048745)3.02021971
58skin morphogenesis (GO:0043589)3.01879780
59cell proliferation involved in metanephros development (GO:0072203)3.01223599
60bundle of His cell to Purkinje myocyte communication (GO:0086069)2.99766327
61negative regulation of protein activation cascade (GO:2000258)2.97613437
62positive regulation of macrophage cytokine production (GO:0060907)2.96224403
63vascular endothelial growth factor signaling pathway (GO:0038084)2.94637068
64kidney mesenchyme development (GO:0072074)2.92656006
65cardiac muscle hypertrophy (GO:0003300)2.92256690
66negative regulation of cartilage development (GO:0061037)2.91464615
67triglyceride catabolic process (GO:0019433)2.90082314
68virion attachment to host cell (GO:0019062)2.88370987
69adhesion of symbiont to host cell (GO:0044650)2.88370987
70valine metabolic process (GO:0006573)2.88135644
71growth hormone receptor signaling pathway (GO:0060396)2.87973449
72carnitine shuttle (GO:0006853)2.87360499
73fatty acid transmembrane transport (GO:1902001)2.86632870
74regulation of integrin-mediated signaling pathway (GO:2001044)2.86163905
75negative regulation of protein localization to cell surface (GO:2000009)2.85960623
76fibroblast migration (GO:0010761)2.85791787
77regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.85444746
78epithelial cell-cell adhesion (GO:0090136)2.83710011
79antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.83424410
80antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.83424410
81negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.82351716
82antigen processing and presentation of endogenous antigen (GO:0019883)2.81301040
83positive regulation of respiratory burst (GO:0060267)2.81129658
84positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)2.80470676
85negative regulation of muscle hypertrophy (GO:0014741)2.79820293
86regulation of macrophage cytokine production (GO:0010935)2.79331486
87lipid particle organization (GO:0034389)2.77702139
88endodermal cell differentiation (GO:0035987)2.76846854
89striated muscle hypertrophy (GO:0014897)2.76802982
90muscle hypertrophy (GO:0014896)2.76615282
91venous blood vessel morphogenesis (GO:0048845)2.76116209
92extracellular matrix organization (GO:0030198)2.74389255
93positive regulation of gastrulation (GO:2000543)2.74383999
94cardiac muscle cell development (GO:0055013)2.74283137
95regulation of p38MAPK cascade (GO:1900744)2.73545220
96extracellular structure organization (GO:0043062)2.73421901
97actomyosin structure organization (GO:0031032)2.72985490
98positive regulation of fatty acid oxidation (GO:0046321)2.72842978
99positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.71594937
100peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.68357943
101regulation of protein activation cascade (GO:2000257)2.67514098
102lung vasculature development (GO:0060426)2.66947171
103keratan sulfate biosynthetic process (GO:0018146)2.66501741
104tooth mineralization (GO:0034505)2.66491726
105positive regulation of endothelial cell apoptotic process (GO:2000353)2.66168782
106cell differentiation involved in metanephros development (GO:0072202)2.65057629
107negative regulation of chondrocyte differentiation (GO:0032331)2.65013993
108cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.61594907
109neuron projection extension involved in neuron projection guidance (GO:1902284)2.60703080
110axon extension involved in axon guidance (GO:0048846)2.60703080
111dermatan sulfate biosynthetic process (GO:0030208)2.60513805
112regulation of skeletal muscle contraction (GO:0014819)2.59641471
113oxygen transport (GO:0015671)2.59187611
114regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)2.58602512
115detection of external biotic stimulus (GO:0098581)2.58528075
116adult heart development (GO:0007512)2.58336277
117negative regulation of cardiac muscle tissue development (GO:0055026)2.57327504
118interleukin-6-mediated signaling pathway (GO:0070102)2.55641245
119regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)2.55425561
120growth hormone secretion (GO:0030252)2.55181268
121regulation of complement activation (GO:0030449)2.54888304
122chondrocyte proliferation (GO:0035988)2.54785509
123adhesion of symbiont to host (GO:0044406)2.54684259
124negative regulation of stress fiber assembly (GO:0051497)2.53975403
125cell proliferation involved in kidney development (GO:0072111)2.52635427
126mesonephros development (GO:0001823)2.51838786
127atrioventricular valve morphogenesis (GO:0003181)2.51062151
128regulation of cardiac muscle cell differentiation (GO:2000725)2.50984568
129endothelial cell morphogenesis (GO:0001886)2.50907862
130acylglycerol catabolic process (GO:0046464)2.50642021
131neutral lipid catabolic process (GO:0046461)2.50642021
132protein trimerization (GO:0070206)2.48860837
133positive regulation of muscle hypertrophy (GO:0014742)2.48290109
134positive regulation of cardiac muscle hypertrophy (GO:0010613)2.48290109
135regulation of cardioblast differentiation (GO:0051890)2.47552526
136barbed-end actin filament capping (GO:0051016)2.47530534
137regulation of cardiac muscle hypertrophy (GO:0010611)2.47340791
138keratan sulfate metabolic process (GO:0042339)2.47120677
139negative regulation of humoral immune response (GO:0002921)2.46853775
140positive regulation of cardiac muscle cell proliferation (GO:0060045)2.46129357
141regulation of phospholipase A2 activity (GO:0032429)2.45801368
142cardiac cell development (GO:0055006)2.44290784
143dermatan sulfate metabolic process (GO:0030205)2.44217757
144cellular response to growth hormone stimulus (GO:0071378)2.42221476
145regulation of muscle hypertrophy (GO:0014743)2.41976553
146positive regulation of chondrocyte differentiation (GO:0032332)2.41901609
147embryonic skeletal joint morphogenesis (GO:0060272)2.41197628
148tachykinin receptor signaling pathway (GO:0007217)2.41150775
149regulation of chemokine-mediated signaling pathway (GO:0070099)2.40943241
150positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.40127412
151relaxation of cardiac muscle (GO:0055119)2.40099028
152atrial septum morphogenesis (GO:0060413)2.39733422
153cardiac muscle tissue morphogenesis (GO:0055008)2.39434999
154positive regulation of cardiac muscle tissue growth (GO:0055023)2.36793202
155regulation of sarcomere organization (GO:0060297)2.36525944
156middle ear morphogenesis (GO:0042474)2.36460535
157muscle tissue morphogenesis (GO:0060415)2.36330419
158positive regulation of cardiac muscle tissue development (GO:0055025)2.34613097
159regulation of relaxation of muscle (GO:1901077)2.34152507
160actin-myosin filament sliding (GO:0033275)2.32683820
161muscle filament sliding (GO:0030049)2.32683820
162actin-mediated cell contraction (GO:0070252)2.32324210
163cardiac chamber formation (GO:0003207)2.31605051
164regulation of cardiac muscle contraction (GO:0055117)2.30820784
165regulation of striated muscle contraction (GO:0006942)2.29576460
166neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.29284609
167response to redox state (GO:0051775)2.28882297
168negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.26966346
169negative regulation of nitric oxide biosynthetic process (GO:0045019)2.25989816
170regulation of organ formation (GO:0003156)2.25851045

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.59432860
2TRIM28_21343339_ChIP-Seq_HEK293_Human5.14269910
3TP63_17297297_ChIP-ChIP_HaCaT_Human3.72488031
4RARG_19884340_ChIP-ChIP_MEFs_Mouse3.22370624
5CLOCK_20551151_ChIP-Seq_293T_Human3.08802912
6ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.74792720
7PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.66785524
8TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.63125627
9GATA1_22025678_ChIP-Seq_K562_Human2.55448950
10EZH2_22144423_ChIP-Seq_EOC_Human2.49150433
11GBX2_23144817_ChIP-Seq_PC3_Human2.41426641
12TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.24076293
13CDX2_19796622_ChIP-Seq_MESCs_Mouse2.15638411
14CJUN_26792858_Chip-Seq_BT549_Human2.14495365
15CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse2.12159918
16GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.07586615
17ESR1_21235772_ChIP-Seq_MCF-7_Human2.03925691
18GATA2_21666600_ChIP-Seq_HMVEC_Human1.91355165
19EP300_21415370_ChIP-Seq_HL-1_Mouse1.90427105
20CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.84551473
21PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.82444251
22STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.76980019
23SMAD_19615063_ChIP-ChIP_OVARY_Human1.76142389
24ESR2_21235772_ChIP-Seq_MCF-7_Human1.73782059
25BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.73438744
26ZFP57_27257070_Chip-Seq_ESCs_Mouse1.62622400
27RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.61135481
28PPAR_26484153_Chip-Seq_NCI-H1993_Human1.60132629
29TP53_16413492_ChIP-PET_HCT116_Human1.58707900
30AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.58216154
31VDR_22108803_ChIP-Seq_LS180_Human1.56960543
32RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.55823813
33NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.55360690
34IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.51410600
35GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.50847957
36FOXO3_23340844_ChIP-Seq_DLD1_Human1.49184358
37RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.48686550
38SMAD4_21799915_ChIP-Seq_A2780_Human1.46591229
39SOX2_20726797_ChIP-Seq_SW620_Human1.44656639
40TBX20_22328084_ChIP-Seq_HEART_Mouse1.40647970
41TBX20_22080862_ChIP-Seq_HEART_Mouse1.40647970
42SOX9_24532713_ChIP-Seq_HFSC_Mouse1.39388321
43SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.39374479
44PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.37674312
45STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.36477766
46THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.25667297
47STAT3_23295773_ChIP-Seq_U87_Human1.25515322
48LXR_22158963_ChIP-Seq_LIVER_Mouse1.25260180
49ARNT_22903824_ChIP-Seq_MCF-7_Human1.24907389
50NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.24656718
51SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.23388621
52NRF2_20460467_ChIP-Seq_MEFs_Mouse1.22758391
53NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.22758391
54ELK3_25401928_ChIP-Seq_HUVEC_Human1.21640162
55SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.20927561
56JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.20119446
57RNF2_18974828_ChIP-Seq_MESCs_Mouse1.18737274
58EZH2_18974828_ChIP-Seq_MESCs_Mouse1.18737274
59SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.17745864
60PCGF2_27294783_Chip-Seq_NPCs_Mouse1.17244315
61SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.15132095
62IRF8_22096565_ChIP-ChIP_GC-B_Human1.15036161
63ZNF217_24962896_ChIP-Seq_MCF-7_Human1.14854093
64EZH2_27294783_Chip-Seq_NPCs_Mouse1.14756796
65PCGF2_27294783_Chip-Seq_ESCs_Mouse1.13992559
66HIF1A_21447827_ChIP-Seq_MCF-7_Human1.13931845
67TCF4_23295773_ChIP-Seq_U87_Human1.13635282
68DROSHA_22980978_ChIP-Seq_HELA_Human1.13462099
69TCF4_18268006_ChIP-ChIP_LS174T_Human1.13059700
70CTBP2_25329375_ChIP-Seq_LNCAP_Human1.12833764
71VDR_24787735_ChIP-Seq_THP-1_Human1.12266221
72JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.11979305
73SMAD3_21741376_ChIP-Seq_HESCs_Human1.11160787
74POU3F2_20337985_ChIP-ChIP_501MEL_Human1.10813310
75SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.10529524
76EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.09891690
77P63_26484246_Chip-Seq_KERATINOCYTES_Human1.09358716
78TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.08755734
79NR3C1_21868756_ChIP-Seq_MCF10A_Human1.08455802
80FLI1_27457419_Chip-Seq_LIVER_Mouse1.08418150
81EGR1_23403033_ChIP-Seq_LIVER_Mouse1.07955973
82FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.07784003
83BRD4_25478319_ChIP-Seq_HGPS_Human1.07706726
84SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.07288321
85ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.06788349
86RXR_22158963_ChIP-Seq_LIVER_Mouse1.06711401
87Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.06595486
88SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.04435817
89SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.04435817
90TP53_18474530_ChIP-ChIP_U2OS_Human1.03736296
91SUZ12_27294783_Chip-Seq_NPCs_Mouse1.03652835
92SMAD3_21741376_ChIP-Seq_EPCs_Human1.03510130
93FOXA2_19822575_ChIP-Seq_HepG2_Human1.03316329
94UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.02891811
95PPARG_20887899_ChIP-Seq_3T3-L1_Mouse1.02619709
96SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.02246938
97STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.01852891
98PIAS1_25552417_ChIP-Seq_VCAP_Human0.99986460
99EED_16625203_ChIP-ChIP_MESCs_Mouse0.99936205
100SMAD4_21741376_ChIP-Seq_HESCs_Human0.99352281
101PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.98953490
102P300_19829295_ChIP-Seq_ESCs_Human0.98697224
103WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.98470224
104CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.98220774
105AR_21572438_ChIP-Seq_LNCaP_Human0.97581559
106SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.97561999
107NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.97442069
108SMAD4_21741376_ChIP-Seq_EPCs_Human0.97194857
109NFIB_24661679_ChIP-Seq_LUNG_Mouse0.97191595
110TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.96468422
111BCAT_22108803_ChIP-Seq_LS180_Human0.96388430
112KDM2B_26808549_Chip-Seq_REH_Human0.96312161
113CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.95821855
114CDX2_22108803_ChIP-Seq_LS180_Human0.95498748
115ESR1_20079471_ChIP-ChIP_T-47D_Human0.95411372
116TOP2B_26459242_ChIP-Seq_MCF-7_Human0.94812312
117CTNNB1_20460455_ChIP-Seq_HCT116_Human0.94518667
118SMC1_22415368_ChIP-Seq_MEFs_Mouse0.94213459
119KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.91973180
120SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.91762759
121ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.91618819
122OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.90970080
123KDM2B_26808549_Chip-Seq_SUP-B15_Human0.90016682
124TP63_23658742_ChIP-Seq_EP156T_Human0.89899046
125SOX2_21211035_ChIP-Seq_LN229_Gbm0.89589329
126RUNX2_22187159_ChIP-Seq_PCA_Human0.89582620
127AR_25329375_ChIP-Seq_VCAP_Human0.89456796
128PPARA_22158963_ChIP-Seq_LIVER_Mouse0.89304838
129SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88385504
130CDX2_20551321_ChIP-Seq_CACO-2_Human0.87772481
131MTF2_20144788_ChIP-Seq_MESCs_Mouse0.86503138
132BP1_19119308_ChIP-ChIP_Hs578T_Human0.86297216
133RACK7_27058665_Chip-Seq_MCF-7_Human0.85631664
134JARID2_20075857_ChIP-Seq_MESCs_Mouse0.85414568
135NR3C1_23031785_ChIP-Seq_PC12_Mouse0.85348599
136FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.85230116
137TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.84633383
138ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.83036057
139LXR_22292898_ChIP-Seq_THP-1_Human0.82472592
140MYB_21317192_ChIP-Seq_ERMYB_Mouse0.81900533
141ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.81584457
142WT1_25993318_ChIP-Seq_PODOCYTE_Human0.81493248
143SALL4_18804426_ChIP-ChIP_XEN_Mouse0.81292093
144RXR_22108803_ChIP-Seq_LS180_Human0.79512885
145PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.78309455
146AHR_22903824_ChIP-Seq_MCF-7_Human0.77245568
147LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.77008701

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen8.29782601
2MP0005275_abnormal_skin_tensile7.01175807
3MP0005503_abnormal_tendon_morphology5.96130445
4MP0003705_abnormal_hypodermis_morpholog3.29345644
5MP0001958_emphysema2.99200923
6MP0000751_myopathy2.91874531
7MP0004272_abnormal_basement_membrane2.68039481
8MP0003279_aneurysm2.61475977
9MP0005670_abnormal_white_adipose2.39423581
10MP0002254_reproductive_system_inflammat2.38589709
11MP0003950_abnormal_plasma_membrane2.32087123
12MP0006054_spinal_hemorrhage2.21638498
13MP0002060_abnormal_skin_morphology2.17202085
14MP0002108_abnormal_muscle_morphology2.16394137
15MP0004185_abnormal_adipocyte_glucose2.03979965
16MP0005666_abnormal_adipose_tissue1.95862404
17MP0002837_dystrophic_cardiac_calcinosis1.87435468
18MP0004130_abnormal_muscle_cell1.83476252
19MP0003566_abnormal_cell_adhesion1.70402570
20MP0001542_abnormal_bone_strength1.62561923
21MP0010368_abnormal_lymphatic_system1.61584535
22MP0005508_abnormal_skeleton_morphology1.60015090
23MP0005375_adipose_tissue_phenotype1.58031013
24MP0009384_cardiac_valve_regurgitation1.51689805
25MP0002127_abnormal_cardiovascular_syste1.46599303
26MP0003045_fibrosis1.44400007
27MP0000013_abnormal_adipose_tissue1.43908183
28MP0005257_abnormal_intraocular_pressure1.43725645
29MP0002166_altered_tumor_susceptibility1.41385988
30MP0002876_abnormal_thyroid_physiology1.41086134
31MP0008004_abnormal_stomach_pH1.32868798
32MP0002295_abnormal_pulmonary_circulatio1.31759729
33MP0000750_abnormal_muscle_regeneration1.27132946
34MP0002006_tumorigenesis1.26526954
35MP0003724_increased_susceptibility_to1.24613796
36MP0002933_joint_inflammation1.22740799
37MP0000749_muscle_degeneration1.22113749
38MP0000343_altered_response_to1.19647565
39MP0005390_skeleton_phenotype1.19422373
40MP0004085_abnormal_heartbeat1.17278872
41MP0001533_abnormal_skeleton_physiology1.17089290
42MP0000003_abnormal_adipose_tissue1.16617820
43MP0005369_muscle_phenotype1.10074953
44MP0001879_abnormal_lymphatic_vessel1.10052268
45MP0003137_abnormal_impulse_conducting1.09953576
46MP0009840_abnormal_foam_cell1.09046478
47MP0009115_abnormal_fat_cell1.09024055
48MP0004036_abnormal_muscle_relaxation1.06885712
49MP0000230_abnormal_systemic_arterial1.06223354
50MP0004134_abnormal_chest_morphology1.05648484
51MP0005023_abnormal_wound_healing1.05316226
52MP0002998_abnormal_bone_remodeling1.05029694
53MP0004145_abnormal_muscle_electrophysio1.03529594
54MP0010386_abnormal_urinary_bladder1.01938230
55MP0002971_abnormal_brown_adipose1.01475959
56MP0004087_abnormal_muscle_fiber1.01033377
57MP0003191_abnormal_cellular_cholesterol0.99056056
58MP0001243_abnormal_dermal_layer0.97537741
59MP0008775_abnormal_heart_ventricle0.97338360
60MP0005620_abnormal_muscle_contractility0.95840268
61MP0002106_abnormal_muscle_physiology0.94427663
62MP0000685_abnormal_immune_system0.93709433
63MP0001348_abnormal_lacrimal_gland0.93635414
64MP0000759_abnormal_skeletal_muscle0.91046521
65MP0002168_other_aberrant_phenotype0.90586865
66MP0000163_abnormal_cartilage_morphology0.90535973
67MP0003646_muscle_fatigue0.89543380
68MP0003828_pulmonary_edema0.88042452
69MP0006138_congestive_heart_failure0.87877873
70MP0004084_abnormal_cardiac_muscle0.87069075
71MP0005164_abnormal_response_to0.85931339
72MP0002896_abnormal_bone_mineralization0.85719850
73MP0003448_altered_tumor_morphology0.83327861
74MP0002269_muscular_atrophy0.83156106
75MP0005410_abnormal_fertilization0.82481513
76MP0001299_abnormal_eye_distance/0.82059584
77MP0002115_abnormal_skeleton_extremities0.81554538
78MP0003942_abnormal_urinary_system0.80682894
79MP0000767_abnormal_smooth_muscle0.80297023
80MP0010630_abnormal_cardiac_muscle0.79810236
81MP0005385_cardiovascular_system_phenoty0.79579388
82MP0001544_abnormal_cardiovascular_syste0.79579388
83MP0003300_gastrointestinal_ulcer0.79174492
84MP0003115_abnormal_respiratory_system0.78326810
85MP0005330_cardiomyopathy0.77535780
86MP0000049_abnormal_middle_ear0.76839550
87MP0001661_extended_life_span0.75337898
88MP0009250_abnormal_appendicular_skeleto0.74473563
89MP0001175_abnormal_lung_morphology0.73309888
90MP0000538_abnormal_urinary_bladder0.72711510
91MP0000747_muscle_weakness0.72582708
92MP0002138_abnormal_hepatobiliary_system0.71266007
93MP0010329_abnormal_lipoprotein_level0.70276424
94MP0002796_impaired_skin_barrier0.70133712
95MP0005334_abnormal_fat_pad0.70064450
96MP0004484_altered_response_of0.69761753
97MP0004883_abnormal_blood_vessel0.69628276
98MP0001986_abnormal_taste_sensitivity0.69345783
99MP0010771_integument_phenotype0.68888211
100MP0002972_abnormal_cardiac_muscle0.67559512
101MP0000733_abnormal_muscle_development0.66986208
102MP0001614_abnormal_blood_vessel0.66487709
103MP0005551_abnormal_eye_electrophysiolog0.66114142
104MP0000266_abnormal_heart_morphology0.66068981
105MP0003252_abnormal_bile_duct0.64193016
106MP0005388_respiratory_system_phenotype0.63114383
107MP0002133_abnormal_respiratory_system0.63114383
108MP0001881_abnormal_mammary_gland0.62650265
109MP0004858_abnormal_nervous_system0.62008507
110MP0003091_abnormal_cell_migration0.60969305
111MP0000249_abnormal_blood_vessel0.60702474
112MP0000579_abnormal_nail_morphology0.60646028
113MP0005165_increased_susceptibility_to0.60449190
114MP0004215_abnormal_myocardial_fiber0.60199610
115MP0000428_abnormal_craniofacial_morphol0.60184280
116MP0009780_abnormal_chondrocyte_physiolo0.59448217
117MP0005595_abnormal_vascular_smooth0.59444398
118MP0002970_abnormal_white_adipose0.58979125
119MP0002128_abnormal_blood_circulation0.58690633
120MP0004510_myositis0.57926828
121MP0002113_abnormal_skeleton_development0.57497576
122MP0004233_abnormal_muscle_weight0.56385434
123MP0003959_abnormal_lean_body0.55525939
124MP0005623_abnormal_meninges_morphology0.55521897
125MP0003385_abnormal_body_wall0.51521379
126MP0001756_abnormal_urination0.50006512

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)6.99642917
2Premature rupture of membranes (HP:0001788)5.75024620
3Broad metatarsal (HP:0001783)5.53595755
4Increased connective tissue (HP:0009025)5.38920835
5Ankle contracture (HP:0006466)5.38565220
6Aortic dissection (HP:0002647)5.37762637
7Type 1 muscle fiber predominance (HP:0003803)5.26545313
8Aortic aneurysm (HP:0004942)4.86896201
9Follicular hyperkeratosis (HP:0007502)4.37551702
10Soft skin (HP:0000977)4.31708634
11Muscle fiber splitting (HP:0003555)3.99610324
12Right ventricular cardiomyopathy (HP:0011663)3.89962066
13Bundle branch block (HP:0011710)3.87577424
14Cerebral aneurysm (HP:0004944)3.85892672
15Round ear (HP:0100830)3.69165223
16Atrial fibrillation (HP:0005110)3.68527433
17Spinal rigidity (HP:0003306)3.64585380
18Fragile skin (HP:0001030)3.49955686
19Slender build (HP:0001533)3.48688981
20Wrist flexion contracture (HP:0001239)3.47654103
21Atrophic scars (HP:0001075)3.45573814
22Primary atrial arrhythmia (HP:0001692)3.40891492
23Dilatation of the ascending aorta (HP:0005111)3.40083904
24Increased variability in muscle fiber diameter (HP:0003557)3.37715479
25Striae distensae (HP:0001065)3.31446527
26Shallow orbits (HP:0000586)3.30739878
27Asymmetric septal hypertrophy (HP:0001670)3.29674527
28Mitral valve prolapse (HP:0001634)3.29474233
29Supraventricular tachycardia (HP:0004755)3.18456906
30Abnormality of skeletal muscle fiber size (HP:0012084)3.16594857
31Bladder diverticulum (HP:0000015)3.15056735
32Vertebral compression fractures (HP:0002953)3.13533557
33Sudden death (HP:0001699)3.09463257
34Supraventricular arrhythmia (HP:0005115)3.08261466
35Mildly elevated creatine phosphokinase (HP:0008180)3.06421856
36Cervical subluxation (HP:0003308)2.95291019
37Wormian bones (HP:0002645)2.95093468
38Hydroxyprolinuria (HP:0003080)2.82817811
39Abnormality of proline metabolism (HP:0010907)2.82817811
40Peritonitis (HP:0002586)2.82095838
41Spondylolisthesis (HP:0003302)2.78398677
42Increased corneal curvature (HP:0100692)2.78354535
43Keratoconus (HP:0000563)2.78354535
44Hyperextensible skin (HP:0000974)2.72120679
45Abnormality of the calf musculature (HP:0001430)2.67124317
46Bradycardia (HP:0001662)2.64204052
47Blue sclerae (HP:0000592)2.61448465
48Wide anterior fontanel (HP:0000260)2.58950129
49Osteolytic defects of the phalanges of the hand (HP:0009771)2.57744249
50Osteolytic defects of the hand bones (HP:0009699)2.57744249
51Genu recurvatum (HP:0002816)2.53529289
52Broad ribs (HP:0000885)2.52162077
53Aortic valve stenosis (HP:0001650)2.51890994
54Abnormality of dentin (HP:0010299)2.49681557
55Aneurysm (HP:0002617)2.48611201
56Abnormal atrioventricular conduction (HP:0005150)2.48007753
57Heart block (HP:0012722)2.46017498
58Bulbous nose (HP:0000414)2.42611006
59Mesomelia (HP:0003027)2.40907442
60Oligomenorrhea (HP:0000876)2.40677889
61Thin bony cortex (HP:0002753)2.40376321
62Rectal prolapse (HP:0002035)2.39542128
63Ulnar deviation of the wrist (HP:0003049)2.38022238
64Aortic regurgitation (HP:0001659)2.36344477
65Pulmonary artery stenosis (HP:0004415)2.35892338
66Overgrowth (HP:0001548)2.35523813
67Hyporeflexia of lower limbs (HP:0002600)2.34886173
68Syncope (HP:0001279)2.33856082
69Acanthosis nigricans (HP:0000956)2.33573418
70Joint laxity (HP:0001388)2.33110480
71Chin dimple (HP:0010751)2.29341276
72Deformed tarsal bones (HP:0008119)2.28459456
73Biconcave vertebral bodies (HP:0004586)2.25829830
74Complement deficiency (HP:0004431)2.25308682
75Coronal craniosynostosis (HP:0004440)2.23185102
76Lipoatrophy (HP:0100578)2.22853052
77Facial diplegia (HP:0001349)2.21193008
78Vascular tortuosity (HP:0004948)2.20946943
79Tarsal synostosis (HP:0008368)2.19523089
80Neonatal short-limb short stature (HP:0008921)2.19213693
81Systemic lupus erythematosus (HP:0002725)2.18749320
82Bowel diverticulosis (HP:0005222)2.15995593
83Osteoarthritis (HP:0002758)2.14586506
84Joint stiffness (HP:0001387)2.13234852
85Abnormal delivery (HP:0001787)2.13065321
86Arterial tortuosity (HP:0005116)2.12470043
87Venous abnormality (HP:0002624)2.12240808
88Limited hip movement (HP:0008800)2.10816251
89Delayed closure of the anterior fontanelle (HP:0001476)2.09935214
90Persistence of primary teeth (HP:0006335)2.08276252
91Abnormality of the acetabulum (HP:0003170)2.07711572
92Ectopia lentis (HP:0001083)2.06448889
93Alopecia of scalp (HP:0002293)2.05871601
94Venous insufficiency (HP:0005293)2.05218452
95Ventricular tachycardia (HP:0004756)2.03830272
96Hypercortisolism (HP:0001578)2.03221508
97Mitral stenosis (HP:0001718)2.02985483
98Short hallux (HP:0010109)1.97263109
99Ventricular arrhythmia (HP:0004308)1.97215029
100Hip contracture (HP:0003273)1.95439489
101Dilated cardiomyopathy (HP:0001644)1.94495364
102Prolonged QT interval (HP:0001657)1.94450807
103Lumbar hyperlordosis (HP:0002938)1.94240877
104Ovoid vertebral bodies (HP:0003300)1.93561964
105Hypoalphalipoproteinemia (HP:0003233)1.93171955
106Elbow flexion contracture (HP:0002987)1.92077169
107Synostosis involving bones of the feet (HP:0009140)1.91800791
108Synostosis involving bones of the lower limbs (HP:0009138)1.91800791
109Gastrointestinal dysmotility (HP:0002579)1.90465169
110Difficulty running (HP:0009046)1.88825665
111Hypoplasia of the iris (HP:0007676)1.88820232
112Radial bowing (HP:0002986)1.88220894
113Generalized amyotrophy (HP:0003700)1.87868508
114Camptodactyly of toe (HP:0001836)1.87851155
115Flat cornea (HP:0007720)1.87709976
116Nephritis (HP:0000123)1.87252546
117Long toe (HP:0010511)1.86632753
118Lymphangioma (HP:0100764)1.85785896
119Mild short stature (HP:0003502)1.85685915
120Hyperlipoproteinemia (HP:0010980)1.85531872
121Emphysema (HP:0002097)1.82463602
122Distal arthrogryposis (HP:0005684)1.80518844
123Aplasia/Hypoplasia of the hallux (HP:0008362)1.79328955
124Abnormal EKG (HP:0003115)1.78740377
125Mitral regurgitation (HP:0001653)1.78480108
126Infantile muscular hypotonia (HP:0008947)1.77682189
127Myotonia (HP:0002486)1.76934476
128Left ventricular hypertrophy (HP:0001712)1.76257592
129Hypertriglyceridemia (HP:0002155)1.76118266
130Abnormality of the anterior chamber (HP:0000593)1.75734053
131Thoracolumbar scoliosis (HP:0002944)1.74698140
132Abnormality of complement system (HP:0005339)1.74085120
133Hematochezia (HP:0002573)1.73819919
134Narrow nasal bridge (HP:0000446)1.72376042
135Calcaneovalgus deformity (HP:0001848)1.68660375
136Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.68656794
137Exercise-induced myalgia (HP:0003738)1.67509408
138Disproportionate tall stature (HP:0001519)1.67101513
139Mesangial abnormality (HP:0001966)1.66648419

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MYLK3.57678341
2TRIB33.53768873
3TTN3.39178323
4ERN13.27776560
5DDR23.25397335
6TGFBR23.12757526
7CAMK1D3.09641247
8RIPK12.85048333
9FRK2.80580323
10SIK12.54044123
11AKT32.45332312
12PDGFRA2.38284358
13ADRBK22.18095108
14GRK12.07770447
15TIE12.06219873
16MST1R2.00622679
17STK38L1.93511132
18MAPKAPK31.90616324
19LMTK21.87976763
20CAMK1G1.87128693
21GRK51.82051610
22DMPK1.80714040
23EPHA31.75390041
24EPHB21.61731713
25STK381.58055266
26JAK31.55247651
27LATS11.49538919
28EPHB11.47099572
29WNK11.46835003
30GRK71.44992052
31KIT1.43103579
32PIK3CA1.42506901
33FGFR41.39734795
34FER1.39252239
35MAPK71.37502053
36FGFR31.35087869
37PIK3CG1.30239971
38FLT31.29536775
39BCKDK1.18140671
40PAK31.17602450
41JAK11.15085746
42PAK21.12172276
43MET1.09721153
44PRKAA21.05984219
45OBSCN1.05743244
46PHKG21.05221534
47PHKG11.05221534
48TGFBR11.05082863
49PTK61.00124277
50MAP3K60.99848527
51PDK40.99815730
52PDK30.99815730
53NLK0.99779627
54INSRR0.99115429
55EEF2K0.96495172
56TRPM70.92282051
57PRKCE0.92041286
58PTK2B0.91153457
59PKN20.90536159
60MAP3K70.90102436
61BLK0.88887589
62MAP2K30.88795197
63MAP4K20.87663786
64MAP2K10.87642124
65MUSK0.86274185
66CAMK40.85069678
67TAOK30.80716792
68PDK20.78744241
69TYK20.78552428
70CSK0.75445431
71PDGFRB0.75095932
72TBK10.74772718
73ILK0.72937845
74PRKG20.72327330
75LATS20.71945177
76MARK20.69354518
77ACVR1B0.69035471
78PTK20.68642741
79JAK20.68110153
80RPS6KA60.66922959
81WNK40.66452221
82RPS6KA20.65777405
83MAP3K30.65648086
84LRRK20.63974010
85GRK60.63348997
86SGK20.62041271
87RPS6KL10.61041447
88RPS6KC10.61041447
89DAPK30.60833456
90PRKG10.60329875
91RET0.60040058
92FGFR20.59832585
93BMX0.59268470
94MAPK40.57920811
95NEK90.55967162
96MAP3K140.55688410
97MAPK110.55075851
98NTRK30.54747046
99PRKCH0.54624101
100ABL20.53340181
101DAPK20.52029218
102MELK0.50345430
103PDPK10.49424734
104PIM20.49096004
105ROCK10.48987993
106CAMKK20.48172377
107IKBKE0.47728087
108PKN10.47654032
109CDC42BPA0.47552723
110MAPKAPK50.46265814
111SGK2230.45754596
112SGK4940.45754596
113PRKD10.45589020
114MAPK120.45487169
115MARK10.45267112
116STK30.44800363
117CAMK10.44357731
118PAK40.43981295
119PINK10.41109394
120ZAP700.40586358
121TEC0.40435339
122SRC0.40155309
123ADRBK10.39853488
124NUAK10.39381711
125GSK3A0.38354919
126MAP3K20.38191863
127CAMK2D0.38066879
128ABL10.37776687
129IGF1R0.37620186
130FGFR10.36080781
131IRAK10.36056120
132CAMK2A0.35647284
133MATK0.34526096
134BMPR1B0.33941489
135STK40.33752311
136MARK30.33497291
137PRKAA10.33437674
138PRKD20.33403073
139HIPK20.33386820
140PDK10.33338214
141PRKACG0.31537672
142MAPK10.31410070
143CDK60.31034066
144MTOR0.30386308
145NTRK10.29738943
146MAP3K10.29397836
147ERBB30.29088979

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045124.10072040
2Protein digestion and absorption_Homo sapiens_hsa049743.35912016
3Regulation of lipolysis in adipocytes_Homo sapiens_hsa049232.58542952
4Caffeine metabolism_Homo sapiens_hsa002322.48627598
5Focal adhesion_Homo sapiens_hsa045102.43350094
6PPAR signaling pathway_Homo sapiens_hsa033202.40011723
7Primary bile acid biosynthesis_Homo sapiens_hsa001201.97489983
8Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.91755541
9Amoebiasis_Homo sapiens_hsa051461.84975623
10Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.82162335
11Malaria_Homo sapiens_hsa051441.76458032
12AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.71250730
13Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.68332804
14Dilated cardiomyopathy_Homo sapiens_hsa054141.67000472
15Fatty acid biosynthesis_Homo sapiens_hsa000611.64897962
16Adipocytokine signaling pathway_Homo sapiens_hsa049201.60654332
17Ovarian steroidogenesis_Homo sapiens_hsa049131.55671450
18Fat digestion and absorption_Homo sapiens_hsa049751.53346290
19Insulin resistance_Homo sapiens_hsa049311.37460292
20Glycerolipid metabolism_Homo sapiens_hsa005611.37365709
21Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.36778597
22Renin-angiotensin system_Homo sapiens_hsa046141.34372542
23Toxoplasmosis_Homo sapiens_hsa051451.32252921
24Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.29879648
252-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.28776952
26Viral myocarditis_Homo sapiens_hsa054161.27133807
27Circadian rhythm_Homo sapiens_hsa047101.24936479
28Propanoate metabolism_Homo sapiens_hsa006401.24433534
29Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.21268653
30Proteoglycans in cancer_Homo sapiens_hsa052051.17145579
31Complement and coagulation cascades_Homo sapiens_hsa046101.15674722
32Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.15467090
33PI3K-Akt signaling pathway_Homo sapiens_hsa041511.13538884
34Fatty acid degradation_Homo sapiens_hsa000711.12887338
35Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.10944190
36Small cell lung cancer_Homo sapiens_hsa052221.10297004
37Retinol metabolism_Homo sapiens_hsa008301.08969239
38Starch and sucrose metabolism_Homo sapiens_hsa005001.08927810
39Adherens junction_Homo sapiens_hsa045201.08870232
40TGF-beta signaling pathway_Homo sapiens_hsa043501.08294702
41AMPK signaling pathway_Homo sapiens_hsa041521.07322675
42Staphylococcus aureus infection_Homo sapiens_hsa051501.07195534
43Steroid hormone biosynthesis_Homo sapiens_hsa001401.04056935
44Fatty acid metabolism_Homo sapiens_hsa012121.01542434
45alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.99199911
46Butanoate metabolism_Homo sapiens_hsa006500.98690762
47Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.98310682
48Linoleic acid metabolism_Homo sapiens_hsa005910.97375710
49TNF signaling pathway_Homo sapiens_hsa046680.97092179
50Pertussis_Homo sapiens_hsa051330.96419318
51Glycosaminoglycan degradation_Homo sapiens_hsa005310.94857930
52Osteoclast differentiation_Homo sapiens_hsa043800.93177745
53Leukocyte transendothelial migration_Homo sapiens_hsa046700.92655091
54Platelet activation_Homo sapiens_hsa046110.92334838
55Hedgehog signaling pathway_Homo sapiens_hsa043400.87936903
56Oxytocin signaling pathway_Homo sapiens_hsa049210.86718765
57Chemical carcinogenesis_Homo sapiens_hsa052040.84603181
58Leishmaniasis_Homo sapiens_hsa051400.84033473
59Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.83400914
60Vascular smooth muscle contraction_Homo sapiens_hsa042700.82504574
61Renin secretion_Homo sapiens_hsa049240.82161556
62Aldosterone synthesis and secretion_Homo sapiens_hsa049250.80792417
63Insulin signaling pathway_Homo sapiens_hsa049100.78746475
64Histidine metabolism_Homo sapiens_hsa003400.78110451
65Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.75729843
66Salivary secretion_Homo sapiens_hsa049700.75197813
67Olfactory transduction_Homo sapiens_hsa047400.74645709
68Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.73464966
69Tyrosine metabolism_Homo sapiens_hsa003500.72829692
70Arachidonic acid metabolism_Homo sapiens_hsa005900.72227104
71Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.71801129
72cGMP-PKG signaling pathway_Homo sapiens_hsa040220.71717107
73Bile secretion_Homo sapiens_hsa049760.71593107
74Mineral absorption_Homo sapiens_hsa049780.71516430
75Morphine addiction_Homo sapiens_hsa050320.70983261
76Lysine degradation_Homo sapiens_hsa003100.70023555
77Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.69993236
78Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.69669171
79Phenylalanine metabolism_Homo sapiens_hsa003600.67459688
80Vitamin digestion and absorption_Homo sapiens_hsa049770.67009914
81Gap junction_Homo sapiens_hsa045400.67002078
82Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.66700078
83Rheumatoid arthritis_Homo sapiens_hsa053230.66320530
84Dorso-ventral axis formation_Homo sapiens_hsa043200.66091708
85ABC transporters_Homo sapiens_hsa020100.64120420
86Circadian entrainment_Homo sapiens_hsa047130.64060063
87Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.63894518
88Galactose metabolism_Homo sapiens_hsa000520.63659735
89Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.62937388
90Phospholipase D signaling pathway_Homo sapiens_hsa040720.62834234
91Regulation of actin cytoskeleton_Homo sapiens_hsa048100.62400349
92Taste transduction_Homo sapiens_hsa047420.61688461
93Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.60315914
94Pathways in cancer_Homo sapiens_hsa052000.59168614
95HIF-1 signaling pathway_Homo sapiens_hsa040660.58100354
96Sphingolipid metabolism_Homo sapiens_hsa006000.57401704
97Hematopoietic cell lineage_Homo sapiens_hsa046400.56768333
98Toll-like receptor signaling pathway_Homo sapiens_hsa046200.56018456
99Central carbon metabolism in cancer_Homo sapiens_hsa052300.55600661
100Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.55476816
101Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.55411468
102Phagosome_Homo sapiens_hsa041450.55102528
103Selenocompound metabolism_Homo sapiens_hsa004500.54968278
104Gastric acid secretion_Homo sapiens_hsa049710.54630220
105Insulin secretion_Homo sapiens_hsa049110.54396115
106beta-Alanine metabolism_Homo sapiens_hsa004100.53898178
107Bladder cancer_Homo sapiens_hsa052190.53885267
108NF-kappa B signaling pathway_Homo sapiens_hsa040640.53204733
109Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.53202939
110Pancreatic cancer_Homo sapiens_hsa052120.51752123
111Tuberculosis_Homo sapiens_hsa051520.51722517
112Acute myeloid leukemia_Homo sapiens_hsa052210.51450202
113Glucagon signaling pathway_Homo sapiens_hsa049220.51315750
114Longevity regulating pathway - mammal_Homo sapiens_hsa042110.51313841
115Apoptosis_Homo sapiens_hsa042100.50873656
116Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.50792296
117Jak-STAT signaling pathway_Homo sapiens_hsa046300.50333410
118Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.49573795
119Pyruvate metabolism_Homo sapiens_hsa006200.48381020
120Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.47021722
121Melanoma_Homo sapiens_hsa052180.46703219
122Glutamatergic synapse_Homo sapiens_hsa047240.46427129
123Lysosome_Homo sapiens_hsa041420.45740040
124African trypanosomiasis_Homo sapiens_hsa051430.44763038
125Cholinergic synapse_Homo sapiens_hsa047250.44307963
126Ether lipid metabolism_Homo sapiens_hsa005650.44077531
127MAPK signaling pathway_Homo sapiens_hsa040100.43922659
128Arginine biosynthesis_Homo sapiens_hsa002200.43733338
129Phototransduction_Homo sapiens_hsa047440.43713125
130Thyroid cancer_Homo sapiens_hsa052160.43637963
131Chronic myeloid leukemia_Homo sapiens_hsa052200.43269658
132Thyroid hormone synthesis_Homo sapiens_hsa049180.42794653
133Legionellosis_Homo sapiens_hsa051340.42742676
134GABAergic synapse_Homo sapiens_hsa047270.42037062
135mTOR signaling pathway_Homo sapiens_hsa041500.40929285
136Glycerophospholipid metabolism_Homo sapiens_hsa005640.40345702
137Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.39014199
138cAMP signaling pathway_Homo sapiens_hsa040240.38789442
139Type II diabetes mellitus_Homo sapiens_hsa049300.37726303
140Hippo signaling pathway_Homo sapiens_hsa043900.37450371
141Tight junction_Homo sapiens_hsa045300.35338777
142Other glycan degradation_Homo sapiens_hsa005110.35189402
143Rap1 signaling pathway_Homo sapiens_hsa040150.34389963
144VEGF signaling pathway_Homo sapiens_hsa043700.34093208
145Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.34035884
146Calcium signaling pathway_Homo sapiens_hsa040200.33655749
147Nitrogen metabolism_Homo sapiens_hsa009100.33228386
148Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.33080802
149Basal cell carcinoma_Homo sapiens_hsa052170.32700601
150Tryptophan metabolism_Homo sapiens_hsa003800.31860996

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