ADCY5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the membrane-bound adenylyl cyclase enzymes. Adenylyl cyclases mediate G protein-coupled receptor signaling through the synthesis of the second messenger cAMP. Activity of the encoded protein is stimulated by the Gs alpha subunit of G protein-coupled receptors and is inhibited by protein kinase A, calcium and Gi alpha subunits. Single nucleotide polymorphisms in this gene may be associated with low birth weight and type 2 diabetes. Alternatively spliced transcript variants that encode different isoforms have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cell communication by electrical coupling involved in cardiac conduction (GO:0086064)6.37820007
2regulation of synapse structural plasticity (GO:0051823)6.05300267
3regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO5.86869509
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.67598037
5cell communication by electrical coupling (GO:0010644)5.56266454
6prepulse inhibition (GO:0060134)5.47753411
7locomotory exploration behavior (GO:0035641)5.47416905
8regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)5.44719023
9synaptic vesicle maturation (GO:0016188)5.38384134
10cardiac muscle contraction (GO:0060048)5.34306944
11synaptic transmission, dopaminergic (GO:0001963)5.31970644
12regulation of actin filament-based movement (GO:1903115)5.30358623
13cell communication involved in cardiac conduction (GO:0086065)5.23855474
14regulation of short-term neuronal synaptic plasticity (GO:0048172)5.21224581
15cardiac myofibril assembly (GO:0055003)5.00235694
16regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)4.94358599
17vocalization behavior (GO:0071625)4.93509118
18sarcomere organization (GO:0045214)4.87537367
19membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.83913963
20regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.82919372
21regulation of long-term neuronal synaptic plasticity (GO:0048169)4.81716144
22auditory behavior (GO:0031223)4.78986475
23positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)4.78582574
24positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.78089405
25striatum development (GO:0021756)4.77213298
26regulation of glutamate receptor signaling pathway (GO:1900449)4.61613906
27negative regulation of cytosolic calcium ion concentration (GO:0051481)4.57692124
28regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)4.55192858
29detection of calcium ion (GO:0005513)4.53596676
30regulation of neuronal synaptic plasticity (GO:0048168)4.51957263
31regulation of cardiac muscle cell contraction (GO:0086004)4.45771603
32regulation of cell communication by electrical coupling (GO:0010649)4.45279669
33cardiac muscle hypertrophy (GO:0003300)4.41359761
34positive regulation of synaptic transmission, dopaminergic (GO:0032226)4.36904059
35positive regulation of synaptic transmission, glutamatergic (GO:0051968)4.36300779
36positive regulation of synaptic transmission, GABAergic (GO:0032230)4.35876025
37neurotransmitter-gated ion channel clustering (GO:0072578)4.35410712
38myofibril assembly (GO:0030239)4.33333565
39regulation of dendritic spine morphogenesis (GO:0061001)4.29245112
40dendritic spine morphogenesis (GO:0060997)4.26102977
41synaptic vesicle exocytosis (GO:0016079)4.17808422
42striated muscle hypertrophy (GO:0014897)4.16932161
43response to amphetamine (GO:0001975)4.16218544
44negative regulation of synaptic transmission, glutamatergic (GO:0051967)4.15569269
45regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)4.14878066
46response to auditory stimulus (GO:0010996)4.11970389
47sodium ion export (GO:0071436)4.04553288
48ionotropic glutamate receptor signaling pathway (GO:0035235)4.04532190
49synaptic vesicle docking involved in exocytosis (GO:0016081)4.04290524
50regulation of synaptic vesicle exocytosis (GO:2000300)4.01822663
51behavioral response to cocaine (GO:0048148)4.01691641
52ventricular cardiac muscle cell action potential (GO:0086005)4.00974180
53regulation of the force of heart contraction (GO:0002026)3.99127497
54positive regulation of neurotransmitter transport (GO:0051590)3.98112706
55protein localization to synapse (GO:0035418)3.94668713
56cAMP catabolic process (GO:0006198)3.93427899
57exploration behavior (GO:0035640)3.88568716
58neuron-neuron synaptic transmission (GO:0007270)3.85704904
59neurotransmitter secretion (GO:0007269)3.84885359
60layer formation in cerebral cortex (GO:0021819)3.84558814
61long-term memory (GO:0007616)3.81872081
62regulation of excitatory postsynaptic membrane potential (GO:0060079)3.80556570
63* neuromuscular process controlling balance (GO:0050885)3.77367158
64cardiac chamber formation (GO:0003207)3.77264122
65actin-myosin filament sliding (GO:0033275)3.75840462
66muscle filament sliding (GO:0030049)3.75840462
67positive regulation of membrane potential (GO:0045838)3.75664629
68substrate-independent telencephalic tangential migration (GO:0021826)3.75627558
69substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.75627558
70regulation of female receptivity (GO:0045924)3.75553315
71neuronal action potential propagation (GO:0019227)3.75063586
72regulation of synaptic transmission, glutamatergic (GO:0051966)3.72409385
73striated muscle contraction (GO:0006941)3.71656406
74transmission of nerve impulse (GO:0019226)3.70603520
75regulation of relaxation of muscle (GO:1901077)3.70288035
76neuronal ion channel clustering (GO:0045161)3.70144750
77regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.69594324
78muscle hypertrophy (GO:0014896)3.69418200
79ventricular cardiac muscle tissue morphogenesis (GO:0055010)3.67616774
80synaptic transmission, glutamatergic (GO:0035249)3.66498338
81G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.65370187
82regulation of heart rate (GO:0002027)3.62575963
83cellular response to epinephrine stimulus (GO:0071872)3.62183516
84gamma-aminobutyric acid transport (GO:0015812)3.61752063
85regulation of glutamate secretion (GO:0014048)3.60010184
86cardiac ventricle formation (GO:0003211)3.59932926
87positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.59538114
88regulation of dopamine uptake involved in synaptic transmission (GO:0051584)3.58460858
89regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)3.58460858
90regulation of synaptic vesicle transport (GO:1902803)3.57303668
91cardiac conduction (GO:0061337)3.57258621
92adult heart development (GO:0007512)3.55452524
93glycine transport (GO:0015816)3.54236507
94cyclic nucleotide catabolic process (GO:0009214)3.52989378
95regulation of postsynaptic membrane potential (GO:0060078)3.51968695
96mechanosensory behavior (GO:0007638)3.50243389
97positive regulation of neurotransmitter secretion (GO:0001956)3.50030808
98regulation of striated muscle contraction (GO:0006942)3.49589132
99* dopamine receptor signaling pathway (GO:0007212)3.49477035
100cardiac muscle cell action potential (GO:0086001)3.48811646
101regulation of synaptic plasticity (GO:0048167)3.45714188
102cardiac muscle hypertrophy in response to stress (GO:0014898)3.43995961
103muscle hypertrophy in response to stress (GO:0003299)3.43995961
104cardiac muscle adaptation (GO:0014887)3.43995961
105glutamate receptor signaling pathway (GO:0007215)3.43961808
106positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.43826956
107regulation of voltage-gated calcium channel activity (GO:1901385)3.43594539
108cardiac muscle cell action potential involved in contraction (GO:0086002)3.43553674
109membrane hyperpolarization (GO:0060081)3.43125768
110glutamate secretion (GO:0014047)3.42529667
111cardiac muscle tissue morphogenesis (GO:0055008)3.41533054
112regulation of neurotransmitter uptake (GO:0051580)3.40167151
113regulation of protein kinase A signaling (GO:0010738)3.39762303
114visual learning (GO:0008542)3.39605923
115regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.37714605
116neuron cell-cell adhesion (GO:0007158)3.33578241
117regulation of dendritic spine development (GO:0060998)3.33149089
118regulation of cardiac muscle contraction (GO:0055117)3.30876760
119actomyosin structure organization (GO:0031032)3.30787496
120cardiac muscle cell development (GO:0055013)3.30485324
121female mating behavior (GO:0060180)3.30220342
122sarcoplasmic reticulum calcium ion transport (GO:0070296)3.29197966
123cellular response to monoamine stimulus (GO:0071868)3.28907126
124cellular response to catecholamine stimulus (GO:0071870)3.28907126
125relaxation of cardiac muscle (GO:0055119)3.27367668
126peristalsis (GO:0030432)3.26235598
127regulation of heart contraction (GO:0008016)3.25688158
128response to epinephrine (GO:0071871)3.25285670
129neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)3.25280595
130mating behavior (GO:0007617)3.24052908
131negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.23201041
132regulation of cardioblast differentiation (GO:0051890)3.22037205
133behavioral fear response (GO:0001662)3.21736443
134behavioral defense response (GO:0002209)3.21736443
135visual behavior (GO:0007632)3.19571092
136negative regulation of potassium ion transmembrane transport (GO:1901380)3.17960078
137regulation of synaptic transmission, GABAergic (GO:0032228)3.16962394
138response to histamine (GO:0034776)3.13800127
139regulation of calcium ion transmembrane transport (GO:1903169)3.13345080
140regulation of calcium ion transmembrane transporter activity (GO:1901019)3.13345080
141regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.11951844
142negative regulation of cardiac muscle cell apoptotic process (GO:0010667)3.11307271
143negative regulation of dendrite development (GO:2000171)3.10926789
144membrane depolarization during action potential (GO:0086010)3.10382106
145membrane depolarization (GO:0051899)3.10363215
146positive regulation of sodium ion transport (GO:0010765)3.09855115
147long-term synaptic potentiation (GO:0060291)3.09198774
148cardiac cell development (GO:0055006)3.08961313
149learning (GO:0007612)3.08409034
150cellular potassium ion homeostasis (GO:0030007)3.07096118
151phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.06383454
152actin-mediated cell contraction (GO:0070252)3.05499013
153muscle tissue morphogenesis (GO:0060415)3.02311635
154negative regulation of amino acid transport (GO:0051956)3.02297073
155adrenergic receptor signaling pathway (GO:0071875)3.02050578
156regulation of heart rate by cardiac conduction (GO:0086091)3.01308474
157* activation of protein kinase A activity (GO:0034199)3.00847648
158positive regulation of synaptic transmission (GO:0050806)3.00092973
159positive regulation of dendritic spine development (GO:0060999)2.99973543
160neurotransmitter transport (GO:0006836)2.99738592
161regulation of membrane repolarization (GO:0060306)2.99406619
162regulation of neurotransmitter levels (GO:0001505)2.98754379
163response to monoamine (GO:0071867)2.97667596
164response to catecholamine (GO:0071869)2.97667596
165neuromuscular process controlling posture (GO:0050884)2.97542389
166adult walking behavior (GO:0007628)2.97468954
167regulation of neurotransmitter transport (GO:0051588)2.97073310
168cellular sodium ion homeostasis (GO:0006883)2.93873899
169L-amino acid import (GO:0043092)2.87057868
170multicellular organismal signaling (GO:0035637)2.85486153
171positive regulation of synapse maturation (GO:0090129)2.83986115
172response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.83104971
173NADH metabolic process (GO:0006734)2.80499046
174positive regulation of action potential (GO:0045760)2.79581583
175bundle of His cell to Purkinje myocyte communication (GO:0086069)2.77174933

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.07253729
2* RARB_27405468_Chip-Seq_BRAIN_Mouse3.64946284
3SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.12530851
4* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.07584841
5* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.92377209
6GBX2_23144817_ChIP-Seq_PC3_Human2.91269884
7DROSHA_22980978_ChIP-Seq_HELA_Human2.84166093
8MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.80572121
9* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.75036322
10* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.75036322
11* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.65377902
12* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.59106786
13SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.57261883
14* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.56532554
15REST_21632747_ChIP-Seq_MESCs_Mouse2.53304138
16* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.53196560
17* EZH2_27304074_Chip-Seq_ESCs_Mouse2.44049449
18SUZ12_27294783_Chip-Seq_ESCs_Mouse2.34857009
19* EZH2_27294783_Chip-Seq_ESCs_Mouse2.28220982
20SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.27535562
21* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.26079318
22* RNF2_27304074_Chip-Seq_ESCs_Mouse2.15166496
23* REST_18959480_ChIP-ChIP_MESCs_Mouse2.12860847
24IKZF1_21737484_ChIP-ChIP_HCT116_Human2.09844712
25AR_21572438_ChIP-Seq_LNCaP_Human2.04286651
26THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.01515737
27EED_16625203_ChIP-ChIP_MESCs_Mouse2.00457565
28ERG_21242973_ChIP-ChIP_JURKAT_Human1.88381861
29ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.87704676
30RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.70041770
31CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.66541859
32NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.52381803
33DNAJC2_21179169_ChIP-ChIP_NT2_Human1.51663606
34TBX20_22080862_ChIP-Seq_HEART_Mouse1.49322785
35TBX20_22328084_ChIP-Seq_HEART_Mouse1.49322785
36EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.48421025
37PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.47945218
38ESR2_21235772_ChIP-Seq_MCF-7_Human1.46498930
39TRIM28_21343339_ChIP-Seq_HEK293_Human1.43295993
40KDM2B_26808549_Chip-Seq_K562_Human1.42453111
41PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.38866436
42* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.38561278
43* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.38098577
44WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.33848736
45RING1B_27294783_Chip-Seq_ESCs_Mouse1.33026494
46* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.31480445
47* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.30773110
48SMAD4_21799915_ChIP-Seq_A2780_Human1.29805653
49* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.28316982
50GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.28246277
51VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.26172449
52* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.26034663
53TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.25664453
54TAF15_26573619_Chip-Seq_HEK293_Human1.25468195
55PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.25024514
56ZFP281_18757296_ChIP-ChIP_E14_Mouse1.24221660
57SOX2_21211035_ChIP-Seq_LN229_Gbm1.23877183
58GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22908753
59* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.22850626
60GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.22762373
61ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.22161153
62FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.21029171
63P53_22127205_ChIP-Seq_FIBROBLAST_Human1.20111216
64* AR_19668381_ChIP-Seq_PC3_Human1.17465027
65CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.16772197
66CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.16027074
67PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.15485753
68* SMAD3_21741376_ChIP-Seq_EPCs_Human1.14120401
69PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.11908334
70CTCF_27219007_Chip-Seq_Bcells_Human1.11334958
71* RING1B_27294783_Chip-Seq_NPCs_Mouse1.11262068
72NR3C1_23031785_ChIP-Seq_PC12_Mouse1.11235077
73STAT3_23295773_ChIP-Seq_U87_Human1.10653515
74ISL1_27105846_Chip-Seq_CPCs_Mouse1.09288582
75CTBP1_25329375_ChIP-Seq_LNCAP_Human1.09043248
76OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.09021087
77* CBX2_27304074_Chip-Seq_ESCs_Mouse1.08933929
78SMAD3_21741376_ChIP-Seq_HESCs_Human1.08171643
79PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.07437054
80* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.05491178
81CDX2_19796622_ChIP-Seq_MESCs_Mouse1.05082485
82ESR1_20079471_ChIP-ChIP_T-47D_Human1.03987104
83CTNNB1_20460455_ChIP-Seq_HCT116_Human0.99035177
84TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.98982211
85* ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.98948120
86SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.98329650
87AHR_22903824_ChIP-Seq_MCF-7_Human0.98209397
88TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97960044
89* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97387217
90KLF4_19829295_ChIP-Seq_ESCs_Human0.96921938
91* ZFP281_27345836_Chip-Seq_ESCs_Mouse0.96412893
92NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.95121579
93RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.94946752
94SMAD4_21741376_ChIP-Seq_HESCs_Human0.94776385
95TET1_21490601_ChIP-Seq_MESCs_Mouse0.94425527
96EP300_21415370_ChIP-Seq_HL-1_Mouse0.94314069
97YAP1_20516196_ChIP-Seq_MESCs_Mouse0.93124978
98* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.92986353
99TP53_20018659_ChIP-ChIP_R1E_Mouse0.92984236
100MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.92963055
101* TCF4_23295773_ChIP-Seq_U87_Human0.92796639
102DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.91753309
103* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.91092456
104SMAD_19615063_ChIP-ChIP_OVARY_Human0.90874793
105RXR_22108803_ChIP-Seq_LS180_Human0.90039453
106P300_19829295_ChIP-Seq_ESCs_Human0.88383479
107* SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.87887689
108ARNT_22903824_ChIP-Seq_MCF-7_Human0.87626069
109KDM2B_26808549_Chip-Seq_SUP-B15_Human0.87461258
110* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.87385882
111SMAD3_21741376_ChIP-Seq_ESCs_Human0.86725404
112LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86642690
113NR3C1_21868756_ChIP-Seq_MCF10A_Human0.85812494
114GATA1_26923725_Chip-Seq_HPCs_Mouse0.85568295
115RNF2_27304074_Chip-Seq_NSC_Mouse0.85420033
116* AR_25329375_ChIP-Seq_VCAP_Human0.85204429
117TP53_16413492_ChIP-PET_HCT116_Human0.84573805
118* TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.84290256
119ZNF274_21170338_ChIP-Seq_K562_Hela0.83663316
120RUNX2_22187159_ChIP-Seq_PCA_Human0.83256341
121BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.83127309
122TOP2B_26459242_ChIP-Seq_MCF-7_Human0.82872687
123PIAS1_25552417_ChIP-Seq_VCAP_Human0.82284326
124SMC4_20622854_ChIP-Seq_HELA_Human0.81263683
125RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.81017921
126* TP53_23651856_ChIP-Seq_MEFs_Mouse0.78153965

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002822_catalepsy7.98491171
2MP0004859_abnormal_synaptic_plasticity6.18607808
3MP0003880_abnormal_central_pattern4.02959491
4MP0003635_abnormal_synaptic_transmissio3.97657052
5* MP0009745_abnormal_behavioral_response3.45030327
6MP0004270_analgesia3.33217243
7MP0002063_abnormal_learning/memory/cond3.30798009
8MP0002064_seizures2.94636586
9MP0009046_muscle_twitch2.76619817
10MP0005670_abnormal_white_adipose2.75532938
11MP0001486_abnormal_startle_reflex2.72669536
12MP0001529_abnormal_vocalization2.70588000
13MP0002572_abnormal_emotion/affect_behav2.66930182
14MP0005423_abnormal_somatic_nervous2.53638507
15MP0002272_abnormal_nervous_system2.48658266
16MP0002909_abnormal_adrenal_gland2.44192521
17MP0001968_abnormal_touch/_nociception2.34373541
18MP0004510_myositis2.31742298
19MP0002734_abnormal_mechanical_nocicepti2.10417441
20MP0006138_congestive_heart_failure2.08303600
21MP0001501_abnormal_sleep_pattern2.06512937
22MP0008775_abnormal_heart_ventricle2.05358875
23MP0005646_abnormal_pituitary_gland2.00938728
24MP0005386_behavior/neurological_phenoty1.96875061
25MP0004924_abnormal_behavior1.96875061
26MP0005385_cardiovascular_system_phenoty1.82297328
27MP0001544_abnormal_cardiovascular_syste1.82297328
28MP0004484_altered_response_of1.80990284
29MP0008569_lethality_at_weaning1.78343201
30MP0001970_abnormal_pain_threshold1.76161535
31MP0005409_darkened_coat_color1.72865588
32MP0000749_muscle_degeneration1.72689248
33MP0010630_abnormal_cardiac_muscle1.70976422
34MP0002733_abnormal_thermal_nociception1.69909803
35MP0009780_abnormal_chondrocyte_physiolo1.66187961
36MP0004811_abnormal_neuron_physiology1.62488273
37MP0002557_abnormal_social/conspecific_i1.57509832
38MP0001440_abnormal_grooming_behavior1.55015548
39MP0002736_abnormal_nociception_after1.50916056
40MP0004885_abnormal_endolymph1.46906502
41MP0003329_amyloid_beta_deposits1.46877072
42MP0002067_abnormal_sensory_capabilities1.46843496
43MP0000751_myopathy1.44785927
44MP0001984_abnormal_olfaction1.43809293
45MP0000013_abnormal_adipose_tissue1.40497206
46MP0005666_abnormal_adipose_tissue1.38192372
47MP0003075_altered_response_to1.36828117
48MP0003633_abnormal_nervous_system1.36540474
49MP0003879_abnormal_hair_cell1.31911253
50MP0005167_abnormal_blood-brain_barrier1.29325468
51MP0003690_abnormal_glial_cell1.29016869
52* MP0002066_abnormal_motor_capabilities/c1.28506773
53MP0008874_decreased_physiological_sensi1.27579638
54MP0001177_atelectasis1.27454050
55MP0000955_abnormal_spinal_cord1.25324772
56MP0002735_abnormal_chemical_nociception1.25072272
57MP0001905_abnormal_dopamine_level1.24238364
58MP0004085_abnormal_heartbeat1.24217268
59MP0002184_abnormal_innervation1.23119000
60MP0002127_abnormal_cardiovascular_syste1.21911859
61MP0001188_hyperpigmentation1.20946066
62MP0002106_abnormal_muscle_physiology1.18398540
63MP0000920_abnormal_myelination1.17052999
64MP0008872_abnormal_physiological_respon1.16710862
65MP0004858_abnormal_nervous_system1.16342295
66MP0000778_abnormal_nervous_system1.15714225
67MP0002882_abnormal_neuron_morphology1.15314743
68MP0002269_muscular_atrophy1.13279521
69MP0003283_abnormal_digestive_organ1.09671861
70MP0003137_abnormal_impulse_conducting1.09073407
71MP0002638_abnormal_pupillary_reflex1.06503462
72MP0003631_nervous_system_phenotype1.06317168
73MP0008961_abnormal_basal_metabolism1.02392156
74MP0002837_dystrophic_cardiac_calcinosis1.01910708
75MP0005369_muscle_phenotype1.01723222
76MP0005375_adipose_tissue_phenotype1.00957153
77MP0005535_abnormal_body_temperature0.97248488
78MP0000750_abnormal_muscle_regeneration0.96812875
79MP0002090_abnormal_vision0.96697831
80MP0001502_abnormal_circadian_rhythm0.94428527
81MP0004142_abnormal_muscle_tone0.92932026
82MP0004215_abnormal_myocardial_fiber0.91460359
83MP0002069_abnormal_eating/drinking_beha0.91239806
84MP0005645_abnormal_hypothalamus_physiol0.90969574
85MP0000759_abnormal_skeletal_muscle0.89880940
86MP0002152_abnormal_brain_morphology0.89305893
87MP0005165_increased_susceptibility_to0.86999911
88MP0004036_abnormal_muscle_relaxation0.85721290
89MP0003634_abnormal_glial_cell0.83167305
90MP0002229_neurodegeneration0.81723730
91MP0004130_abnormal_muscle_cell0.81681401
92MP0002971_abnormal_brown_adipose0.80525112
93MP0010234_abnormal_vibrissa_follicle0.77050377
94MP0000569_abnormal_digit_pigmentation0.76729341
95MP0003828_pulmonary_edema0.75587278
96MP0010368_abnormal_lymphatic_system0.74128807
97MP0005620_abnormal_muscle_contractility0.73268176
98MP0003787_abnormal_imprinting0.72166018
99MP0003646_muscle_fatigue0.71289331
100MP0006276_abnormal_autonomic_nervous0.70577843
101MP0000003_abnormal_adipose_tissue0.70086422
102MP0004043_abnormal_pH_regulation0.65697492
103MP0000631_abnormal_neuroendocrine_gland0.63840628
104MP0004145_abnormal_muscle_electrophysio0.63553270
105MP0001485_abnormal_pinna_reflex0.62346306
106MP0000604_amyloidosis0.61863271
107MP0005551_abnormal_eye_electrophysiolog0.61624597
108MP0003279_aneurysm0.61443833
109MP0003122_maternal_imprinting0.61015855
110MP0003632_abnormal_nervous_system0.60566575
111MP0002108_abnormal_muscle_morphology0.58043638
112MP0004742_abnormal_vestibular_system0.57788015
113MP0005499_abnormal_olfactory_system0.57721177
114MP0005394_taste/olfaction_phenotype0.57721177
115MP0000462_abnormal_digestive_system0.57297813
116MP0000266_abnormal_heart_morphology0.57033331
117MP0002234_abnormal_pharynx_morphology0.57021305
118MP0002295_abnormal_pulmonary_circulatio0.56953109
119MP0004233_abnormal_muscle_weight0.56736564
120MP0001664_abnormal_digestion0.56531707
121MP0005623_abnormal_meninges_morphology0.54740030
122MP0000747_muscle_weakness0.54424987
123MP0004084_abnormal_cardiac_muscle0.52413444
124MP0005330_cardiomyopathy0.50731885
125MP0005166_decreased_susceptibility_to0.49796459
126MP0004087_abnormal_muscle_fiber0.49202379
127MP0002972_abnormal_cardiac_muscle0.48816411
128MP0001943_abnormal_respiration0.48647379
129MP0000230_abnormal_systemic_arterial0.47863475

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.14253789
2* Myokymia (HP:0002411)6.74407623
3Focal seizures (HP:0007359)5.41406590
4Ventricular tachycardia (HP:0004756)5.36307075
5Hyporeflexia of lower limbs (HP:0002600)4.90971955
6Right ventricular cardiomyopathy (HP:0011663)4.38049531
7Lipoatrophy (HP:0100578)4.37020105
8Ventricular arrhythmia (HP:0004308)4.32839122
9Torticollis (HP:0000473)4.31065903
10Action tremor (HP:0002345)4.20579184
11Ankle clonus (HP:0011448)4.13327411
12Muscle fiber splitting (HP:0003555)4.11814827
13Visual hallucinations (HP:0002367)4.06472517
14Poor eye contact (HP:0000817)4.03615773
15Annular pancreas (HP:0001734)3.80513727
16Impaired social interactions (HP:0000735)3.69691092
17Abnormal social behavior (HP:0012433)3.69691092
18Focal dystonia (HP:0004373)3.65984159
19Depression (HP:0000716)3.61799364
20Craniofacial dystonia (HP:0012179)3.60131589
21Impaired vibration sensation in the lower limbs (HP:0002166)3.59043252
22Prolonged QT interval (HP:0001657)3.56240478
23Broad-based gait (HP:0002136)3.53169415
24Abnormality of the calf musculature (HP:0001430)3.47169594
25Subaortic stenosis (HP:0001682)3.46610145
26Abnormality of the left ventricular outflow tract (HP:0011103)3.46610145
27Dysdiadochokinesis (HP:0002075)3.45792374
28* Dilated cardiomyopathy (HP:0001644)3.42622063
29Epileptic encephalopathy (HP:0200134)3.40854007
30Urinary bladder sphincter dysfunction (HP:0002839)3.38703610
31Generalized tonic-clonic seizures (HP:0002069)3.33766477
32EMG: neuropathic changes (HP:0003445)3.31606212
33Papilledema (HP:0001085)3.18967206
34Urinary urgency (HP:0000012)3.15197779
35* Anxiety (HP:0000739)3.15123998
36Asymmetric septal hypertrophy (HP:0001670)3.14699510
37Dysmetria (HP:0001310)3.14353407
38Gaze-evoked nystagmus (HP:0000640)3.12799055
39Ankyloglossia (HP:0010296)3.12739161
40Supranuclear gaze palsy (HP:0000605)3.11143161
41Postural instability (HP:0002172)3.09370521
42Abnormal EKG (HP:0003115)3.07420855
43Febrile seizures (HP:0002373)3.06866261
44Absence seizures (HP:0002121)3.06162044
45Lower limb amyotrophy (HP:0007210)3.04309673
46Atrioventricular block (HP:0001678)3.02714450
47Scanning speech (HP:0002168)3.00983857
48Dysmetric saccades (HP:0000641)2.99229014
49Distal lower limb muscle weakness (HP:0009053)2.97317648
50Ventricular fibrillation (HP:0001663)2.89966941
51Intention tremor (HP:0002080)2.88404080
52Dialeptic seizures (HP:0011146)2.88039526
53EMG: myopathic abnormalities (HP:0003458)2.86408629
54Spastic gait (HP:0002064)2.85552603
55Abnormality of the foot musculature (HP:0001436)2.84469212
56Truncal ataxia (HP:0002078)2.84113438
57Pointed chin (HP:0000307)2.82554928
58Left ventricular hypertrophy (HP:0001712)2.82036932
59Stereotypic behavior (HP:0000733)2.81752339
60Atonic seizures (HP:0010819)2.78069407
61Progressive cerebellar ataxia (HP:0002073)2.77820409
62Abnormal eating behavior (HP:0100738)2.77184307
63Heart block (HP:0012722)2.70938573
64Bundle branch block (HP:0011710)2.64372698
65Foot dorsiflexor weakness (HP:0009027)2.58637433
66Megalencephaly (HP:0001355)2.57107383
67Atrial fibrillation (HP:0005110)2.56887602
68Neurofibrillary tangles (HP:0002185)2.55428947
69Sudden death (HP:0001699)2.54167525
70Limb dystonia (HP:0002451)2.54047645
71Primary atrial arrhythmia (HP:0001692)2.53418934
72Palpitations (HP:0001962)2.51819225
73Polygenic inheritance (HP:0010982)2.51432751
74Mutism (HP:0002300)2.51362335
75Bradycardia (HP:0001662)2.47895810
76Abnormal atrioventricular conduction (HP:0005150)2.46014616
77Difficulty running (HP:0009046)2.44378693
78Calf muscle hypertrophy (HP:0008981)2.43795934
79Impaired vibratory sensation (HP:0002495)2.43182049
80Lower limb muscle weakness (HP:0007340)2.42432787
81Bradykinesia (HP:0002067)2.41971057
82Clonus (HP:0002169)2.41016912
83Impaired smooth pursuit (HP:0007772)2.38629702
84Supraventricular tachycardia (HP:0004755)2.37525599
85Hypoplastic left heart (HP:0004383)2.37458976
86Insidious onset (HP:0003587)2.35640282
87Termporal pattern (HP:0011008)2.35640282
88Distal lower limb amyotrophy (HP:0008944)2.31858904
89Abnormality of oral frenula (HP:0000190)2.31849121
90Supraventricular arrhythmia (HP:0005115)2.30842428
91Abnormality of the lower motor neuron (HP:0002366)2.29668285
92Sudden cardiac death (HP:0001645)2.28251369
93Cerebral inclusion bodies (HP:0100314)2.27160241
94Hemiplegia (HP:0002301)2.25206990
95Progressive inability to walk (HP:0002505)2.23307402
96Upper limb amyotrophy (HP:0009129)2.22001951
97Distal upper limb amyotrophy (HP:0007149)2.22001951
98Incomplete penetrance (HP:0003829)2.17349527
99Onion bulb formation (HP:0003383)2.17013695
100Hemiparesis (HP:0001269)2.14974628
101Amblyopia (HP:0000646)2.11268909
102Diplopia (HP:0000651)2.10627062
103Abnormality of binocular vision (HP:0011514)2.10627062
104Muscle hypertrophy of the lower extremities (HP:0008968)2.10426285
105Pheochromocytoma (HP:0002666)2.09681032
106Increased variability in muscle fiber diameter (HP:0003557)2.09372764
107Syncope (HP:0001279)2.07684402
108Hyperventilation (HP:0002883)2.06311488
109Exercise-induced myalgia (HP:0003738)2.05324943
110Double outlet right ventricle (HP:0001719)2.03972095
111Congenital malformation of the right heart (HP:0011723)2.03972095
112Neuronal loss in central nervous system (HP:0002529)2.03073052
113Abnormality of the corticospinal tract (HP:0002492)2.02998956
114Abnormality of ocular smooth pursuit (HP:0000617)2.01284657
115Abnormality of saccadic eye movements (HP:0000570)2.00764144
116Insomnia (HP:0100785)2.00023667
117Obstructive sleep apnea (HP:0002870)1.99870481
118Abnormality of the periventricular white matter (HP:0002518)1.99612807
119Truncus arteriosus (HP:0001660)1.99314300
120Centrally nucleated skeletal muscle fibers (HP:0003687)1.98004521
121Axonal loss (HP:0003447)1.97528752
122Aplasia involving bones of the extremities (HP:0009825)1.97263451
123Aplasia involving bones of the upper limbs (HP:0009823)1.97263451
124Aplasia of the phalanges of the hand (HP:0009802)1.97263451
125Steppage gait (HP:0003376)1.94165558
126Genetic anticipation (HP:0003743)1.93728639
127Bowel incontinence (HP:0002607)1.93668595
128Lymphangioma (HP:0100764)1.91816574
129Neoplasm of the peripheral nervous system (HP:0100007)1.91391792
130Status epilepticus (HP:0002133)1.91276119
131Lower limb asymmetry (HP:0100559)1.89903031
132Neck muscle weakness (HP:0000467)1.87917772
133Drooling (HP:0002307)1.87171267
134Ragged-red muscle fibers (HP:0003200)1.86951392
135Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.83975968
136Myotonia (HP:0002486)1.83261704
137Hypoplastic heart (HP:0001961)1.79091333
138Type 1 muscle fiber predominance (HP:0003803)1.76878946
139Rapidly progressive (HP:0003678)1.75603253
140Slow progression (HP:0003677)1.73674005
141Frequent falls (HP:0002359)1.73334360
142Palmoplantar keratoderma (HP:0000982)1.71694257
143Polyphagia (HP:0002591)1.68197572
144Hypercortisolism (HP:0001578)1.67604903
145Skin nodule (HP:0200036)1.66829375
146Scapular winging (HP:0003691)1.66027534
147Mildly elevated creatine phosphokinase (HP:0008180)1.65250477
148Tetraplegia (HP:0002445)1.64442054
149Turricephaly (HP:0000262)1.63389318
150Sleep apnea (HP:0010535)1.62819795

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA47.18325199
2NTRK33.82493457
3MYLK3.65632982
4MAP3K93.45629171
5KSR22.74179306
6PRKD32.73024058
7DAPK22.70506537
8TTN2.40866134
9CAMKK12.22985544
10RIPK42.21860539
11NTRK12.15526444
12MINK12.12441435
13MARK12.07091876
14OBSCN2.02122802
15NTRK22.00187067
16PAK61.94792832
17MAP3K41.88980186
18FES1.77520036
19CASK1.74664387
20TAOK11.67073563
21CDK51.62606380
22ARAF1.62494003
23MAP3K131.61492955
24KSR11.55185623
25TNIK1.49028657
26MAPK121.48922923
27TYRO31.48327603
28MAP3K21.48164911
29CAMKK21.31238599
30DAPK11.26472251
31SIK21.24877928
32PIK3CA1.24702429
33LMTK21.23045728
34MAP2K71.21727636
35PRPF4B1.20269693
36PINK11.17048644
37STK381.14796468
38RAF11.10474323
39PRKCH1.10108974
40SGK2231.08837010
41SGK4941.08837010
42MAP2K41.04800779
43UHMK11.04652574
44PHKG21.01082477
45PHKG11.01082477
46RIPK10.97657882
47PKN10.97326914
48MARK20.94407499
49STK110.92943450
50ROCK20.91265070
51DMPK0.90094554
52PDPK10.86493560
53RET0.85629109
54PRKAA10.85181880
55CAMK10.84124362
56TRIB30.83578076
57CAMK2A0.82394042
58SGK30.81979218
59CDK150.80992118
60SGK10.80271047
61SGK20.79993459
62BMPR20.79950312
63PRKCG0.79657503
64CDK180.79515795
65CDK140.77720821
66CAMK2B0.77253679
67ALK0.77049222
68PDK10.76556457
69NEK10.76128389
70TIE10.75469702
71MAPK130.75049877
72MAP3K10.72978921
73GRK50.72248216
74MAPK40.71766064
75PTK2B0.69829651
76CDK11A0.69357763
77DYRK1A0.69100510
78NEK60.68698234
79WNK10.67836376
80TNK20.65403746
81LIMK10.65261238
82PRKAA20.63076242
83MAP3K50.62591400
84DAPK30.59385391
85EPHA30.59086985
86MAP3K60.59040012
87FYN0.58041598
88GRK70.57835832
89MAP2K10.57616816
90EPHB20.57438986
91RPS6KA30.57197570
92PAK30.56159264
93FGFR20.55970929
94PKN20.54884415
95PRKD20.54695826
96PRKACA0.54578110
97CAMK2D0.52827702
98RPS6KA20.52667087
99PRKG10.52186420
100CAMK40.51455495
101PRKCZ0.51292470
102MAPKAPK30.50819038
103CDC42BPA0.50113321
104CDK190.48713079
105BRSK10.47597866
106TESK10.47497988
107MAPK100.47330071
108OXSR10.46794052
109PDGFRA0.44435380
110STK390.44073737
111CAMK2G0.43882628
112PRKD10.43220439
113MAP3K120.42999491
114PRKCE0.40048161
115PLK20.38277922
116CSNK1G20.37291805
117MAP3K70.36741175
118DDR20.36098935
119MUSK0.35359181
120MAPK70.34732096
121LATS20.34518149
122PRKACG0.33172419
123PRKCB0.32929294
124MOS0.32722203
125ROCK10.32667646
126CAMK1G0.31773384
127ICK0.31585300

Predicted pathways (KEGG)

RankGene SetZ-score
1Olfactory transduction_Homo sapiens_hsa047403.69323177
2Nicotine addiction_Homo sapiens_hsa050332.83627671
3* Morphine addiction_Homo sapiens_hsa050322.75740978
4Synaptic vesicle cycle_Homo sapiens_hsa047212.65638246
5* Circadian entrainment_Homo sapiens_hsa047132.63966776
6* GABAergic synapse_Homo sapiens_hsa047272.61890075
7Long-term potentiation_Homo sapiens_hsa047202.52903488
8* Glutamatergic synapse_Homo sapiens_hsa047242.42224173
9* Amphetamine addiction_Homo sapiens_hsa050312.39115564
10* Cocaine addiction_Homo sapiens_hsa050302.28102402
11* Dopaminergic synapse_Homo sapiens_hsa047282.27492690
12* Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.23582497
13* Cholinergic synapse_Homo sapiens_hsa047252.12544105
14Nitrogen metabolism_Homo sapiens_hsa009101.98099059
15Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.94306382
162-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.94190944
17* Salivary secretion_Homo sapiens_hsa049701.88993443
18* Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.83193300
19* Renin secretion_Homo sapiens_hsa049241.79111196
20Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.77816368
21Calcium signaling pathway_Homo sapiens_hsa040201.74915448
22* Aldosterone synthesis and secretion_Homo sapiens_hsa049251.72298786
23* Oxytocin signaling pathway_Homo sapiens_hsa049211.72201804
24* Gastric acid secretion_Homo sapiens_hsa049711.67492853
25* Insulin secretion_Homo sapiens_hsa049111.60667182
26Long-term depression_Homo sapiens_hsa047301.53700285
27Taste transduction_Homo sapiens_hsa047421.44597397
28* Gap junction_Homo sapiens_hsa045401.44555579
29* Serotonergic synapse_Homo sapiens_hsa047261.42992074
30* cAMP signaling pathway_Homo sapiens_hsa040241.40475964
31PPAR signaling pathway_Homo sapiens_hsa033201.37118228
32* GnRH signaling pathway_Homo sapiens_hsa049121.31417122
33Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.28980469
34Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.23152175
35Type II diabetes mellitus_Homo sapiens_hsa049301.19446269
36Glioma_Homo sapiens_hsa052141.19107269
37Cardiac muscle contraction_Homo sapiens_hsa042601.18064101
38Phenylalanine metabolism_Homo sapiens_hsa003601.16824096
39* Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.12697484
40Phosphatidylinositol signaling system_Homo sapiens_hsa040701.08895858
41* cGMP-PKG signaling pathway_Homo sapiens_hsa040221.07556124
42* Vascular smooth muscle contraction_Homo sapiens_hsa042701.01425473
43* Dilated cardiomyopathy_Homo sapiens_hsa054141.00389522
44Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.99823552
45Axon guidance_Homo sapiens_hsa043600.97686274
46ErbB signaling pathway_Homo sapiens_hsa040120.97165328
47* Phospholipase D signaling pathway_Homo sapiens_hsa040720.95071945
48Propanoate metabolism_Homo sapiens_hsa006400.92967915
49Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.91492679
50* Estrogen signaling pathway_Homo sapiens_hsa049150.91320639
51Pyruvate metabolism_Homo sapiens_hsa006200.89794006
52Dorso-ventral axis formation_Homo sapiens_hsa043200.89262762
53Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.89044547
54AMPK signaling pathway_Homo sapiens_hsa041520.84935389
55Fatty acid metabolism_Homo sapiens_hsa012120.83972991
56Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.83899813
57Arginine and proline metabolism_Homo sapiens_hsa003300.82541520
58Non-small cell lung cancer_Homo sapiens_hsa052230.81833370
59Phototransduction_Homo sapiens_hsa047440.81477566
60Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.80390794
61* Melanogenesis_Homo sapiens_hsa049160.80385851
62* Ovarian steroidogenesis_Homo sapiens_hsa049130.78500776
63beta-Alanine metabolism_Homo sapiens_hsa004100.75912740
64* Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.73682628
65Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.73613108
66Choline metabolism in cancer_Homo sapiens_hsa052310.73169480
67* Alcoholism_Homo sapiens_hsa050340.72531828
68Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.72510937
69Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.72371101
70Histidine metabolism_Homo sapiens_hsa003400.71617920
71MAPK signaling pathway_Homo sapiens_hsa040100.71478284
72* Rap1 signaling pathway_Homo sapiens_hsa040150.70580832
73Thyroid hormone signaling pathway_Homo sapiens_hsa049190.69183789
74VEGF signaling pathway_Homo sapiens_hsa043700.69114700
75Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.68542205
76Fatty acid degradation_Homo sapiens_hsa000710.67780833
77Collecting duct acid secretion_Homo sapiens_hsa049660.67021578
78* Oocyte meiosis_Homo sapiens_hsa041140.65227975
79Neurotrophin signaling pathway_Homo sapiens_hsa047220.64439901
80* Pancreatic secretion_Homo sapiens_hsa049720.63042328
81Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.62005350
82Sphingolipid signaling pathway_Homo sapiens_hsa040710.61735879
83Ras signaling pathway_Homo sapiens_hsa040140.61313291
84Vitamin B6 metabolism_Homo sapiens_hsa007500.59935787
85mTOR signaling pathway_Homo sapiens_hsa041500.59634016
86Carbon metabolism_Homo sapiens_hsa012000.58715725
87Focal adhesion_Homo sapiens_hsa045100.58407789
88Endocytosis_Homo sapiens_hsa041440.57444178
89Glucagon signaling pathway_Homo sapiens_hsa049220.57103889
90Butanoate metabolism_Homo sapiens_hsa006500.56457139
91Type I diabetes mellitus_Homo sapiens_hsa049400.55725347
92Renal cell carcinoma_Homo sapiens_hsa052110.53144620
93Carbohydrate digestion and absorption_Homo sapiens_hsa049730.52052191
94Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.51583633
95Prion diseases_Homo sapiens_hsa050200.51501131
96* Thyroid hormone synthesis_Homo sapiens_hsa049180.51079120
97Endometrial cancer_Homo sapiens_hsa052130.49940118
98ECM-receptor interaction_Homo sapiens_hsa045120.49463132
99Glycerolipid metabolism_Homo sapiens_hsa005610.49260037
100Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.49231277
101Insulin signaling pathway_Homo sapiens_hsa049100.48817689
102Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.46466978
103* Chemokine signaling pathway_Homo sapiens_hsa040620.46423777
104Alzheimers disease_Homo sapiens_hsa050100.45085973
105Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.42565812
106Vibrio cholerae infection_Homo sapiens_hsa051100.42042350
107Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.41269847
108Glycerophospholipid metabolism_Homo sapiens_hsa005640.39718503
109* Longevity regulating pathway - mammal_Homo sapiens_hsa042110.39571331
110Insulin resistance_Homo sapiens_hsa049310.39243130
111Arginine biosynthesis_Homo sapiens_hsa002200.39232650
112Inositol phosphate metabolism_Homo sapiens_hsa005620.39174860
113Circadian rhythm_Homo sapiens_hsa047100.38686917
114Adherens junction_Homo sapiens_hsa045200.38058772
115Fatty acid elongation_Homo sapiens_hsa000620.37414767
116Adipocytokine signaling pathway_Homo sapiens_hsa049200.37382709
117Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.37246029
118Fatty acid biosynthesis_Homo sapiens_hsa000610.36916215
119Tight junction_Homo sapiens_hsa045300.36104939
120* Bile secretion_Homo sapiens_hsa049760.32660791
121* Platelet activation_Homo sapiens_hsa046110.31884575
122African trypanosomiasis_Homo sapiens_hsa051430.29462942
123Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.28934965
124Regulation of actin cytoskeleton_Homo sapiens_hsa048100.28485986
125* Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.27078764

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