ADCY4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the family of adenylate cyclases, which are membrane-associated enzymes that catalyze the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). Mouse studies show that adenylate cyclase 4, along with adenylate cyclases 2 and 3, is expressed in olfactory cilia, suggesting that several different adenylate cyclases may couple to olfactory receptors and that there may be multiple receptor-mediated mechanisms for the generation of cAMP signals. Alternative splicing results in transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1lymph vessel development (GO:0001945)7.55305262
2vascular endothelial growth factor signaling pathway (GO:0038084)7.36651123
3lymphangiogenesis (GO:0001946)6.08491086
4endothelium development (GO:0003158)6.04052853
5cellular response to vascular endothelial growth factor stimulus (GO:0035924)5.99054386
6heart trabecula formation (GO:0060347)5.32728890
7retina vasculature morphogenesis in camera-type eye (GO:0061299)5.19134833
8surfactant homeostasis (GO:0043129)5.11648551
9blood vessel maturation (GO:0001955)5.10777701
10positive regulation of vasculogenesis (GO:2001214)5.09766826
11endothelial tube morphogenesis (GO:0061154)4.96220533
12morphogenesis of an endothelium (GO:0003159)4.96220533
13regulation of endothelial cell differentiation (GO:0045601)4.91507822
14regulation of vasculogenesis (GO:2001212)4.55177761
15vascular endothelial growth factor receptor signaling pathway (GO:0048010)4.52369903
16sprouting angiogenesis (GO:0002040)4.42845093
17endothelial cell morphogenesis (GO:0001886)4.39918910
18glomerular filtration (GO:0003094)4.21939274
19tooth mineralization (GO:0034505)4.19164651
20blood vessel endothelial cell migration (GO:0043534)4.05937273
21chemical homeostasis within a tissue (GO:0048875)4.03220640
22renal filtration (GO:0097205)4.02585430
23endothelial cell differentiation (GO:0045446)3.99728963
24basement membrane organization (GO:0071711)3.94184381
25patterning of blood vessels (GO:0001569)3.88117659
26negative regulation of T-helper cell differentiation (GO:0045623)3.82713222
27negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.82713222
28cell migration involved in sprouting angiogenesis (GO:0002042)3.81303667
29regulation of T-helper 2 cell differentiation (GO:0045628)3.76548059
30ovulation from ovarian follicle (GO:0001542)3.71940414
31transcytosis (GO:0045056)3.67325958
32venous blood vessel morphogenesis (GO:0048845)3.61320466
33trabecula formation (GO:0060343)3.58191459
34negative regulation of blood vessel endothelial cell migration (GO:0043537)3.51371901
35positive regulation of endothelial cell differentiation (GO:0045603)3.50335279
36negative regulation of endothelial cell apoptotic process (GO:2000352)3.44867253
37negative regulation of type 2 immune response (GO:0002829)3.43629784
38negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)3.43576300
39negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.41468260
40cardiac myofibril assembly (GO:0055003)3.40076298
41endothelial cell proliferation (GO:0001935)3.38220354
42negative regulation of endothelial cell migration (GO:0010596)3.35323245
43endothelial cell chemotaxis (GO:0035767)3.34461147
44vasculogenesis (GO:0001570)3.34068776
45positive regulation of focal adhesion assembly (GO:0051894)3.29500564
46positive regulation of cell junction assembly (GO:1901890)3.29500564
47bundle of His cell to Purkinje myocyte communication (GO:0086069)3.28407080
48plasma membrane repair (GO:0001778)3.25874488
49regulation of cell migration involved in sprouting angiogenesis (GO:0090049)3.25319706
50regulation of vascular permeability (GO:0043114)3.22861063
51regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030947)3.18716650
52sarcomere organization (GO:0045214)3.18609847
53regulation of sequestering of triglyceride (GO:0010889)3.15725451
54protein heterotrimerization (GO:0070208)3.15535126
55fat-soluble vitamin biosynthetic process (GO:0042362)3.13818095
56triglyceride catabolic process (GO:0019433)3.13015469
57positive regulation of adherens junction organization (GO:1903393)3.10679175
58establishment of endothelial barrier (GO:0061028)3.10462727
59endothelial cell migration (GO:0043542)3.06857974
60low-density lipoprotein particle clearance (GO:0034383)3.06781761
61embryonic heart tube development (GO:0035050)3.05934009
62negative regulation of vascular permeability (GO:0043116)3.04677154
63peptidyl-tyrosine autophosphorylation (GO:0038083)2.99197925
64lung vasculature development (GO:0060426)2.96484026
65fatty acid transmembrane transport (GO:1902001)2.96231042
66cellular response to epinephrine stimulus (GO:0071872)2.94373498
67positive regulation of receptor recycling (GO:0001921)2.94138597
68myofibril assembly (GO:0030239)2.93240031
69blood vessel remodeling (GO:0001974)2.92731967
70positive regulation of endothelial cell proliferation (GO:0001938)2.91628940
71negative regulation of actin filament bundle assembly (GO:0032232)2.89106065
72peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.85017546
73negative regulation of platelet activation (GO:0010544)2.84577108
74cell migration involved in heart development (GO:0060973)2.84418882
75regulation of endothelial cell apoptotic process (GO:2000351)2.84068165
76ventricular cardiac muscle tissue morphogenesis (GO:0055010)2.80482644
77negative regulation of epithelial cell migration (GO:0010633)2.79472899
78neutral lipid catabolic process (GO:0046461)2.78804920
79acylglycerol catabolic process (GO:0046464)2.78804920
80regulation of endothelial cell migration (GO:0010594)2.76756075
81negative regulation of Rho protein signal transduction (GO:0035024)2.75660107
82regulation of p38MAPK cascade (GO:1900744)2.73021638
83coronary vasculature morphogenesis (GO:0060977)2.72859428
84neuron projection extension involved in neuron projection guidance (GO:1902284)2.72491227
85axon extension involved in axon guidance (GO:0048846)2.72491227
86blood vessel morphogenesis (GO:0048514)2.71479628
87cardiac muscle cell proliferation (GO:0060038)2.69885547
88regulation of endothelial cell proliferation (GO:0001936)2.68371585
89trabecula morphogenesis (GO:0061383)2.68244459
90* cAMP biosynthetic process (GO:0006171)2.68002173
91positive regulation of endothelial cell migration (GO:0010595)2.67978362
92negative regulation of nitric-oxide synthase activity (GO:0051001)2.67634409
93negative regulation of endothelial cell proliferation (GO:0001937)2.67114304
94regulation of T-helper 1 cell differentiation (GO:0045625)2.66298510
95ventricular trabecula myocardium morphogenesis (GO:0003222)2.66284688
96cGMP-mediated signaling (GO:0019934)2.66027911
97angiogenesis involved in wound healing (GO:0060055)2.62158667
98substrate-dependent cell migration (GO:0006929)2.61269294
99regulation of cardioblast differentiation (GO:0051890)2.60710385
100regulation of actin filament-based movement (GO:1903115)2.60478296
101negative regulation of angiogenesis (GO:0016525)2.60238027
102cardiac muscle tissue morphogenesis (GO:0055008)2.59158106
103negative regulation of blood vessel morphogenesis (GO:2000181)2.59074395
104regulation of relaxation of muscle (GO:1901077)2.56777434
105positive regulation of protein kinase C signaling (GO:0090037)2.55837117
106carnitine shuttle (GO:0006853)2.55229312
107heterotypic cell-cell adhesion (GO:0034113)2.54619832
108negative regulation of granulocyte differentiation (GO:0030853)2.52792833
109negative regulation of alpha-beta T cell differentiation (GO:0046639)2.52359038
110regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.49439719
111heart trabecula morphogenesis (GO:0061384)2.49066116
112response to epinephrine (GO:0071871)2.48782173
113negative regulation of erythrocyte differentiation (GO:0045647)2.48749572
114regulation of cholesterol storage (GO:0010885)2.48727083
115positive regulation of p38MAPK cascade (GO:1900745)2.47789314
116regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.47534234
117positive regulation of phosphatidylinositol 3-kinase activity (GO:0043552)2.46358159
118actin-myosin filament sliding (GO:0033275)2.46040899
119muscle filament sliding (GO:0030049)2.46040899
120actomyosin structure organization (GO:0031032)2.45903137
121gap junction assembly (GO:0016264)2.45776125
122regulation of skeletal muscle contraction (GO:0014819)2.45751382
123negative regulation of vasculature development (GO:1901343)2.45585385
124barbed-end actin filament capping (GO:0051016)2.45340039
125angiogenesis (GO:0001525)2.45235830
126negative regulation of protein autophosphorylation (GO:0031953)2.41843270
127positive regulation of protein sumoylation (GO:0033235)2.39691555
128hyaluronan catabolic process (GO:0030214)2.39227640
129negative regulation of homotypic cell-cell adhesion (GO:0034111)2.37834434
130detection of chemical stimulus involved in sensory perception of smell (GO:0050911)2.32171823
131regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.31857017
132mannose metabolic process (GO:0006013)2.28401917
133extracellular matrix assembly (GO:0085029)2.26033723
134phagocytosis, recognition (GO:0006910)2.22708486
135polyol transport (GO:0015791)2.22330580
136diacylglycerol metabolic process (GO:0046339)2.21036324
137actin-mediated cell contraction (GO:0070252)2.20555034
138regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.19445921
139cardiac muscle contraction (GO:0060048)2.17745056
140* activation of protein kinase A activity (GO:0034199)2.17735697
141positive regulation of odontogenesis (GO:0042482)2.14124171
142germinal center formation (GO:0002467)2.13488583
143negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.12462433
144regulation of type 2 immune response (GO:0002828)2.12446958
145lipid storage (GO:0019915)2.09154907
146negative regulation of alpha-beta T cell activation (GO:0046636)2.09115516
147positive regulation of steroid hormone secretion (GO:2000833)2.09095248
148keratan sulfate catabolic process (GO:0042340)2.08559691
149response to dietary excess (GO:0002021)2.08265858
150positive regulation of cholesterol efflux (GO:0010875)2.08200902
151atrioventricular valve morphogenesis (GO:0003181)2.07538464
152positive regulation of triglyceride lipase activity (GO:0061365)2.06994798
153positive regulation of lipoprotein lipase activity (GO:0051006)2.06994798
154cardiac muscle hypertrophy (GO:0003300)2.06282830
155detection of other organism (GO:0098543)2.05828496
156fibril organization (GO:0097435)2.03013509
157positive regulation of macrophage derived foam cell differentiation (GO:0010744)2.02098108
158stress fiber assembly (GO:0043149)1.99892420
159negative regulation of smooth muscle cell proliferation (GO:0048662)1.99433283
160endocrine hormone secretion (GO:0060986)1.99084671

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.16819736
2BP1_19119308_ChIP-ChIP_Hs578T_Human4.60764676
3ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.54539265
4CLOCK_20551151_ChIP-Seq_293T_Human3.37991006
5TRIM28_21343339_ChIP-Seq_HEK293_Human3.36527354
6GATA2_21666600_ChIP-Seq_HMVEC_Human3.15859015
7RARG_19884340_ChIP-ChIP_MEFs_Mouse3.07076340
8EP300_21415370_ChIP-Seq_HL-1_Mouse2.66715109
9LXR_22158963_ChIP-Seq_LIVER_Mouse2.43454028
10RXR_22158963_ChIP-Seq_LIVER_Mouse2.37954764
11THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.35871154
12TP63_17297297_ChIP-ChIP_HaCaT_Human2.34670275
13ESR1_20079471_ChIP-ChIP_T-47D_Human2.32009707
14STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.28489047
15GATA1_22025678_ChIP-Seq_K562_Human2.23355517
16TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.16773804
17* ELK3_25401928_ChIP-Seq_HUVEC_Human2.15971001
18PPARA_22158963_ChIP-Seq_LIVER_Mouse2.12930039
19NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.12889595
20* TBX20_22080862_ChIP-Seq_HEART_Mouse2.12779096
21* TBX20_22328084_ChIP-Seq_HEART_Mouse2.12779096
22NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.02275987
23ESR2_21235772_ChIP-Seq_MCF-7_Human2.00176787
24TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.96771753
25TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.92851642
26ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.91374078
27FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.87431578
28IRF8_22096565_ChIP-ChIP_GC-B_Human1.85733511
29EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.76982152
30KDM2B_26808549_Chip-Seq_SUP-B15_Human1.75912382
31ESR1_21235772_ChIP-Seq_MCF-7_Human1.72545164
32STAT6_21828071_ChIP-Seq_BEAS2B_Human1.68744444
33PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.65797920
34PPAR_26484153_Chip-Seq_NCI-H1993_Human1.63028475
35HIF1A_21447827_ChIP-Seq_MCF-7_Human1.60935350
36GATA1_19941826_ChIP-Seq_K562_Human1.56514756
37FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.50691697
38CJUN_26792858_Chip-Seq_BT549_Human1.49886430
39BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.49079922
40SALL4_18804426_ChIP-ChIP_XEN_Mouse1.47514486
41ZNF263_19887448_ChIP-Seq_K562_Human1.46435661
42CDX2_19796622_ChIP-Seq_MESCs_Mouse1.32855381
43SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.29391198
44RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.28757079
45STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.28407645
46FOXO3_23340844_ChIP-Seq_DLD1_Human1.27701702
47CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.27252849
48MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.24322774
49EED_16625203_ChIP-ChIP_MESCs_Mouse1.21016400
50RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.19026643
51SOX9_24532713_ChIP-Seq_HFSC_Mouse1.18771335
52VDR_24763502_ChIP-Seq_THP-1_Human1.18617475
53LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.18085467
54DNAJC2_21179169_ChIP-ChIP_NT2_Human1.16711714
55CDX2_20551321_ChIP-Seq_CACO-2_Human1.15948644
56VDR_21846776_ChIP-Seq_THP-1_Human1.15868928
57EGR1_19374776_ChIP-ChIP_THP-1_Human1.15404215
58* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.13739401
59KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.13113599
60JARID2_20075857_ChIP-Seq_MESCs_Mouse1.12571908
61IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.12174470
62ZNF217_24962896_ChIP-Seq_MCF-7_Human1.10969721
63LXR_22292898_ChIP-Seq_THP-1_Human1.09854734
64NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.08925498
65TCF7_22412390_ChIP-Seq_EML_Mouse1.08764059
66RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.08542046
67SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.07860286
68WT1_19549856_ChIP-ChIP_CCG9911_Human1.07202245
69CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.06980736
70SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.06764832
71SOX2_20726797_ChIP-Seq_SW620_Human1.05651905
72VDR_24787735_ChIP-Seq_THP-1_Human1.05077350
73SMAD_19615063_ChIP-ChIP_OVARY_Human1.04914406
74GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.04242736
75* GATA1_19941827_ChIP-Seq_MEL_Mouse1.04103475
76SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.04005628
77JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.03964100
78ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.03856561
79Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.03236342
80* FOXA2_19822575_ChIP-Seq_HepG2_Human1.03234597
81* CTCF_27219007_Chip-Seq_Bcells_Human1.02930720
82SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.01955907
83PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.01287095
84IRF8_27001747_Chip-Seq_BMDM_Mouse1.00918976
85EZH2_27294783_Chip-Seq_ESCs_Mouse1.00436742
86SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.00397725
87STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.99722259
88* RACK7_27058665_Chip-Seq_MCF-7_Human0.99142739
89SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.98462611
90AR_21572438_ChIP-Seq_LNCaP_Human0.97945400
91SPI1_23127762_ChIP-Seq_K562_Human0.97699152
92* KDM2B_26808549_Chip-Seq_K562_Human0.97667329
93SCL_19346495_ChIP-Seq_HPC-7_Human0.97476997
94FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.96924403
95GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96781807
96SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.96751086
97IKZF1_21737484_ChIP-ChIP_HCT116_Human0.96296693
98SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.96239774
99SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.96239774
100RNF2_18974828_ChIP-Seq_MESCs_Mouse0.95283647
101EZH2_18974828_ChIP-Seq_MESCs_Mouse0.95283647
102JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.95262619
103ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.94910742
104RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.94822931
105EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.94439633
106* CTCF_27219007_Chip-Seq_ERYTHROID_Human0.94044144
107GATA2_19941826_ChIP-Seq_K562_Human0.93635351
108VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.93182318
109* SMC3_22415368_ChIP-Seq_MEFs_Mouse0.92949514
110TCF4_18268006_ChIP-ChIP_LS174T_Human0.92486343
111NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.92139835
112SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90839474
113PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.90443522
114LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.90335568
115* KDM2B_26808549_Chip-Seq_DND41_Human0.90074883
116SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.89938651
117WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.89756627
118NFIB_24661679_ChIP-Seq_LUNG_Mouse0.89645024
119SUZ12_27294783_Chip-Seq_ESCs_Mouse0.89602439
120MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.89339474
121* ISL1_27105846_Chip-Seq_CPCs_Mouse0.88983694
122DROSHA_22980978_ChIP-Seq_HELA_Human0.88591501
123PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.87786387
124RXR_22108803_ChIP-Seq_LS180_Human0.87255331
125SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.86989462
126ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.86607973
127RNF2_27304074_Chip-Seq_ESCs_Mouse0.86217756
128MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.85795722
129UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.85716476
130PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.85495185
131GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.84986815
132TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.84859969
133WT1_25993318_ChIP-Seq_PODOCYTE_Human0.84436102
134RUNX_20019798_ChIP-Seq_JUKART_Human0.83472023
135NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.83071303
136NRF2_20460467_ChIP-Seq_MEFs_Mouse0.83071303
137* SMC1_22415368_ChIP-Seq_MEFs_Mouse0.82873021
138AHR_22903824_ChIP-Seq_MCF-7_Human0.82646611
139MTF2_20144788_ChIP-Seq_MESCs_Mouse0.81856391
140BRD4_25478319_ChIP-Seq_HGPS_Human0.79021435
141SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.78401886

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010368_abnormal_lymphatic_system6.78634833
2MP0001879_abnormal_lymphatic_vessel5.26215938
3MP0005167_abnormal_blood-brain_barrier4.45039787
4MP0004272_abnormal_basement_membrane3.72836812
5MP0003724_increased_susceptibility_to3.65896231
6MP0004084_abnormal_cardiac_muscle3.47993801
7MP0006054_spinal_hemorrhage2.88290793
8MP0003828_pulmonary_edema2.74000922
9MP0006138_congestive_heart_failure2.66388778
10MP0004215_abnormal_myocardial_fiber2.59958459
11MP0002837_dystrophic_cardiac_calcinosis2.31981124
12MP0004036_abnormal_muscle_relaxation2.28147857
13MP0000751_myopathy2.27882822
14MP0001544_abnormal_cardiovascular_syste1.98268568
15MP0005385_cardiovascular_system_phenoty1.98268568
16MP0000767_abnormal_smooth_muscle1.96894765
17MP0000013_abnormal_adipose_tissue1.94078640
18MP0005330_cardiomyopathy1.93982986
19MP0003705_abnormal_hypodermis_morpholog1.93022029
20MP0002933_joint_inflammation1.91879990
21MP0005670_abnormal_white_adipose1.91816923
22MP0003279_aneurysm1.88761643
23MP0008775_abnormal_heart_ventricle1.86314856
24MP0008438_abnormal_cutaneous_collagen1.85137015
25MP0004130_abnormal_muscle_cell1.75005573
26MP0010630_abnormal_cardiac_muscle1.74932236
27MP0002138_abnormal_hepatobiliary_system1.69494636
28MP0004484_altered_response_of1.67959090
29MP0000343_altered_response_to1.66643134
30MP0008961_abnormal_basal_metabolism1.65927642
31MP0002972_abnormal_cardiac_muscle1.64229447
32MP0005165_increased_susceptibility_to1.63320213
33MP0002971_abnormal_brown_adipose1.53899498
34MP0001958_emphysema1.53241866
35MP0005084_abnormal_gallbladder_morpholo1.52242029
36MP0000249_abnormal_blood_vessel1.49208987
37MP0000750_abnormal_muscle_regeneration1.49111139
38MP0002127_abnormal_cardiovascular_syste1.47808252
39MP0002128_abnormal_blood_circulation1.45761983
40MP0003566_abnormal_cell_adhesion1.43695237
41MP0004087_abnormal_muscle_fiber1.43675860
42MP0000749_muscle_degeneration1.40867162
43MP0005595_abnormal_vascular_smooth1.37609303
44MP0005620_abnormal_muscle_contractility1.37391811
45MP0004085_abnormal_heartbeat1.30849052
46MP0005623_abnormal_meninges_morphology1.28535410
47MP0002295_abnormal_pulmonary_circulatio1.27324874
48MP0002332_abnormal_exercise_endurance1.24998035
49MP0003300_gastrointestinal_ulcer1.24170004
50MP0002925_abnormal_cardiovascular_devel1.23976582
51MP0003646_muscle_fatigue1.22226951
52MP0002998_abnormal_bone_remodeling1.21194365
53MP0008004_abnormal_stomach_pH1.20024733
54MP0001614_abnormal_blood_vessel1.18847118
55MP0003191_abnormal_cellular_cholesterol1.17540838
56MP0003436_decreased_susceptibility_to1.14181361
57MP0009115_abnormal_fat_cell1.13697853
58MP0005360_urolithiasis1.12046286
59MP0001851_eye_inflammation1.09725132
60MP0003567_abnormal_fetal_cardiomyocyte1.09046772
61MP0005275_abnormal_skin_tensile1.09023059
62MP0000003_abnormal_adipose_tissue1.08622827
63MP0002419_abnormal_innate_immunity1.07834196
64MP0000266_abnormal_heart_morphology1.06788908
65MP0010329_abnormal_lipoprotein_level1.06387634
66MP0004510_myositis1.05054110
67MP0004782_abnormal_surfactant_physiolog1.03571544
68MP0005666_abnormal_adipose_tissue1.03492400
69MP0002106_abnormal_muscle_physiology1.01300056
70MP0005375_adipose_tissue_phenotype0.98974419
71MP0003303_peritoneal_inflammation0.98347324
72MP0005164_abnormal_response_to0.97356900
73MP0005448_abnormal_energy_balance0.96579088
74MP0003690_abnormal_glial_cell0.96255233
75MP0001915_intracranial_hemorrhage0.95961725
76MP0004883_abnormal_blood_vessel0.95899418
77MP0005334_abnormal_fat_pad0.95755531
78MP0004145_abnormal_muscle_electrophysio0.93408578
79MP0005085_abnormal_gallbladder_physiolo0.93201826
80MP0005535_abnormal_body_temperature0.91665571
81MP0004147_increased_porphyrin_level0.91587528
82MP0009278_abnormal_bone_marrow0.90769054
83MP0005369_muscle_phenotype0.90745440
84MP0005390_skeleton_phenotype0.90188610
85MP0000230_abnormal_systemic_arterial0.89982030
86MP0001790_abnormal_immune_system0.89792226
87MP0005387_immune_system_phenotype0.89792226
88MP0003950_abnormal_plasma_membrane0.88612840
89MP0005397_hematopoietic_system_phenotyp0.84625916
90MP0001545_abnormal_hematopoietic_system0.84625916
91MP0009785_altered_susceptibility_to0.83268106
92MP0002108_abnormal_muscle_morphology0.83216509
93MP0009384_cardiac_valve_regurgitation0.82573660
94MP0003137_abnormal_impulse_conducting0.82486584
95MP0000465_gastrointestinal_hemorrhage0.82443014
96MP0000747_muscle_weakness0.82416039
97MP0005025_abnormal_response_to0.82364737
98MP0004185_abnormal_adipocyte_glucose0.80059835
99MP0005058_abnormal_lysosome_morphology0.79357205
100MP0001542_abnormal_bone_strength0.78731829
101MP0005365_abnormal_bile_salt0.78289287
102MP0001784_abnormal_fluid_regulation0.77730307
103MP0009697_abnormal_copulation0.77484482
104MP0002139_abnormal_hepatobiliary_system0.77069504
105MP0008875_abnormal_xenobiotic_pharmacok0.76319279
106MP0003091_abnormal_cell_migration0.76107859
107MP0003075_altered_response_to0.75898241
108MP0000759_abnormal_skeletal_muscle0.74952794
109MP0005388_respiratory_system_phenotype0.73450477
110MP0002133_abnormal_respiratory_system0.73450477
111MP0005409_darkened_coat_color0.68877520
112MP0005319_abnormal_enzyme/_coenzyme0.66539222
113MP0003252_abnormal_bile_duct0.66381815
114MP0005083_abnormal_biliary_tract0.63635753
115MP0009764_decreased_sensitivity_to0.63189521
116MP0000733_abnormal_muscle_development0.62510308
117MP0005187_abnormal_penis_morphology0.60335792
118MP0002269_muscular_atrophy0.59824699
119MP0005503_abnormal_tendon_morphology0.59665054
120MP0009840_abnormal_foam_cell0.59314579
121MP0005023_abnormal_wound_healing0.57229967
122MP0009643_abnormal_urine_homeostasis0.56806152
123MP0001533_abnormal_skeleton_physiology0.56614137
124MP0003385_abnormal_body_wall0.56504852
125MP0003045_fibrosis0.56155139

Predicted human phenotypes

RankGene SetZ-score
1Polycythemia (HP:0001901)5.65730125
2Spontaneous hematomas (HP:0007420)4.72291573
3Ventricular tachycardia (HP:0004756)4.64969427
4Hematochezia (HP:0002573)4.56424044
5Sudden death (HP:0001699)4.47441675
6Muscle fiber splitting (HP:0003555)4.41468867
7Nonimmune hydrops fetalis (HP:0001790)4.40031051
8Broad metatarsal (HP:0001783)4.33211943
9Esophageal varix (HP:0002040)4.28885519
10Increased connective tissue (HP:0009025)3.99875788
11Lymphangioma (HP:0100764)3.80895965
12Atrial fibrillation (HP:0005110)3.80290635
13Hyporeflexia of lower limbs (HP:0002600)3.75905042
14Deep venous thrombosis (HP:0002625)3.70090530
15Supraventricular arrhythmia (HP:0005115)3.58064708
16Cerebral aneurysm (HP:0004944)3.56270575
17Overgrowth (HP:0001548)3.55934527
18Primary atrial arrhythmia (HP:0001692)3.50844655
19Abnormality of the nasal mucosa (HP:0000433)3.47737870
20Right ventricular cardiomyopathy (HP:0011663)3.42497777
21Supraventricular tachycardia (HP:0004755)3.33705865
22Lipoatrophy (HP:0100578)3.30915150
23Cerebral hemorrhage (HP:0001342)3.27414500
24Exercise-induced muscle cramps (HP:0003710)3.08543417
25Difficulty running (HP:0009046)3.07823776
26Round ear (HP:0100830)3.05610732
27Cervical subluxation (HP:0003308)2.94642645
28Visceral angiomatosis (HP:0100761)2.93590589
29Conjunctival telangiectasia (HP:0000524)2.92013541
30Exercise-induced myalgia (HP:0003738)2.82539999
31Mesangial abnormality (HP:0001966)2.76700307
32Dilated cardiomyopathy (HP:0001644)2.73508471
33Hemangiomatosis (HP:0007461)2.72267104
34Calf muscle hypertrophy (HP:0008981)2.70985487
35Increased variability in muscle fiber diameter (HP:0003557)2.69321067
36Hypoglycemic coma (HP:0001325)2.68844864
37Systemic lupus erythematosus (HP:0002725)2.64494483
38Atrioventricular block (HP:0001678)2.58273472
39Syncope (HP:0001279)2.58117059
40Abnormality of complement system (HP:0005339)2.57594632
41Cavernous hemangioma (HP:0001048)2.56054008
42Hypertriglyceridemia (HP:0002155)2.56035768
43Myoglobinuria (HP:0002913)2.55487393
44Hypoplastic ischia (HP:0003175)2.54967104
45Aneurysm (HP:0002617)2.54951242
46Joint hemorrhage (HP:0005261)2.54516993
47Joint stiffness (HP:0001387)2.54400814
48EMG: myopathic abnormalities (HP:0003458)2.53389663
49Abnormality of the calf musculature (HP:0001430)2.52474333
50Abnormality of skeletal muscle fiber size (HP:0012084)2.50673268
51Protrusio acetabuli (HP:0003179)2.48921931
52Asymmetric septal hypertrophy (HP:0001670)2.47836404
53Short hallux (HP:0010109)2.47790585
54Hemorrhage of the eye (HP:0011885)2.47242311
55Pulmonary artery stenosis (HP:0004415)2.46631982
56Abnormality of the vasculature of the conjunctiva (HP:0008054)2.46559227
57Adactyly (HP:0009776)2.46167917
58Obstructive sleep apnea (HP:0002870)2.44769895
59Neck muscle weakness (HP:0000467)2.43410355
60Hyperlipoproteinemia (HP:0010980)2.42838978
61Portal hypertension (HP:0001409)2.41097265
62Aortic aneurysm (HP:0004942)2.40557820
63Muscle hypertrophy of the lower extremities (HP:0008968)2.39169594
64Wrist flexion contracture (HP:0001239)2.39094642
65Arterial tortuosity (HP:0005116)2.38743565
66Abnormality of the ischium (HP:0003174)2.38004241
67Difficulty climbing stairs (HP:0003551)2.33992586
68Spinal rigidity (HP:0003306)2.32852678
69Venous insufficiency (HP:0005293)2.31428941
70Mildly elevated creatine phosphokinase (HP:0008180)2.30763418
71Oligomenorrhea (HP:0000876)2.30464007
72Prolonged QT interval (HP:0001657)2.29462729
73Distal lower limb amyotrophy (HP:0008944)2.28145419
74Subaortic stenosis (HP:0001682)2.28118398
75Abnormality of the left ventricular outflow tract (HP:0011103)2.28118398
76Aplasia/Hypoplasia of the hallux (HP:0008362)2.26730346
77Venous abnormality (HP:0002624)2.23583543
78Heart block (HP:0012722)2.23550490
79Premature rupture of membranes (HP:0001788)2.22497046
80Eczematoid dermatitis (HP:0000976)2.21839233
81Aortic dissection (HP:0002647)2.21046752
82Porencephaly (HP:0002132)2.20170423
83Colitis (HP:0002583)2.20115312
84Absent hand (HP:0004050)2.19821275
85Abnormal atrioventricular conduction (HP:0005150)2.19395328
86Muscle fiber inclusion bodies (HP:0100299)2.19258797
87Stroke (HP:0001297)2.18369658
88Palpitations (HP:0001962)2.15959474
89Hypoalphalipoproteinemia (HP:0003233)2.15705024
90Striae distensae (HP:0001065)2.15512224
91Aortic valve stenosis (HP:0001650)2.14990103
92Abnormality of the intrinsic pathway (HP:0010989)2.13946261
93Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.13654616
94Aortic regurgitation (HP:0001659)2.13269870
95Abnormality of fatty-acid metabolism (HP:0004359)2.12868377
96Abnormality of the hepatic vasculature (HP:0006707)2.12680286
97Neonatal death (HP:0003811)2.12347948
98Hyperinsulinemic hypoglycemia (HP:0000825)2.11306021
99Rhabdomyolysis (HP:0003201)2.11248782
100Centrally nucleated skeletal muscle fibers (HP:0003687)2.10636677
101Myotonia (HP:0002486)2.10629697
102Axonal loss (HP:0003447)2.09271832
103Acanthosis nigricans (HP:0000956)2.08723098
104Shallow orbits (HP:0000586)2.08541867
105Muscle stiffness (HP:0003552)2.06345435
106Myositis (HP:0100614)2.06325135
107Abnormality of polysaccharide metabolism (HP:0011012)2.05561688
108Abnormality of glycosaminoglycan metabolism (HP:0004371)2.05561688
109Abnormality of mucopolysaccharide metabolism (HP:0011020)2.05561688
110Mucosal telangiectasiae (HP:0100579)2.04910597
111Distal lower limb muscle weakness (HP:0009053)2.02976956
112Recurrent gram-negative bacterial infections (HP:0005420)2.02813106
113Skull defect (HP:0001362)2.02346019
114Dilatation of the ascending aorta (HP:0005111)2.01803758
115Type 1 muscle fiber predominance (HP:0003803)2.01191988
116Mucopolysacchariduria (HP:0008155)2.00269929
117Urinary glycosaminoglycan excretion (HP:0003541)2.00269929
118Prolonged bleeding time (HP:0003010)1.99538693
119Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.99230935
120Nemaline bodies (HP:0003798)1.99076890
121Ectopia lentis (HP:0001083)1.98196757
122Cardiovascular calcification (HP:0011915)1.94839433
123EMG: neuropathic changes (HP:0003445)1.94159444
124Complement deficiency (HP:0004431)1.92610258
125Microcytic anemia (HP:0001935)1.92185019
126Bulbar palsy (HP:0001283)1.91992871
127Emphysema (HP:0002097)1.91586094
128Tetraparesis (HP:0002273)1.90582414
129Dysostosis multiplex (HP:0000943)1.90082876
130Bundle branch block (HP:0011710)1.89752877
131Mitral valve prolapse (HP:0001634)1.89635708
132Ventricular arrhythmia (HP:0004308)1.87383628
133Amyloidosis (HP:0011034)1.86470992
134Vascular tortuosity (HP:0004948)1.84564988
135Facial diplegia (HP:0001349)1.83712629
136Pulmonary embolism (HP:0002204)1.83514880
137Hemoptysis (HP:0002105)1.82392988
138Pulmonary hypertension (HP:0002092)1.82194216
139Lymphedema (HP:0001004)1.80789500
140Abnormality of the foot musculature (HP:0001436)1.80259279
141Congenital, generalized hypertrichosis (HP:0004540)1.80195971
142Chondrocalcinosis (HP:0000934)1.79611708
143Skin nodule (HP:0200036)1.79437834
144Xanthomatosis (HP:0000991)1.78852119
145Nuclear cataract (HP:0100018)1.78089554
146Hip contracture (HP:0003273)1.76909319

Predicted kinase interactions (KEA)

RankGene SetZ-score
1KDR6.26099519
2TGFBR23.33016298
3BLK2.23761262
4MAP3K62.10979351
5TTN2.10200808
6TGFBR12.07393363
7TIE112.0598418
8RIPK11.94145507
9GRK11.91122628
10CDC42BPA1.90780423
11ERN11.80276551
12NTRK21.79076655
13MYLK1.63959869
14FES1.61976138
15EPHB21.60562811
16RIPK41.59416632
17PTK2B1.56153352
18TRIB31.49530956
19DDR21.46261234
20CAMK1D1.41232107
21KIT1.40561212
22TNK21.38867691
23PKN21.33777590
24ZAP701.33527786
25MARK21.30763466
26CAMK1G1.22529639
27EPHB11.20682973
28DMPK1.17245874
29PDK21.14566669
30MAP2K31.11055702
31TEC1.08931179
32BMX1.03879802
33PTK61.03786947
34FGFR41.00754604
35BCKDK0.99670689
36MAP3K130.98706334
37PDGFRA0.96735457
38FER0.94302630
39LMTK20.87977452
40MAPK120.87380995
41PIK3CG0.86155923
42MAP3K30.86111043
43OBSCN0.81700022
44HCK0.80746864
45PHKG20.80742385
46PHKG10.80742385
47RPS6KC10.80469955
48RPS6KL10.80469955
49PRKG20.80285250
50RPS6KA20.79642351
51INSRR0.78537476
52MAP2K60.75510421
53HIPK20.75463548
54PRKD10.75442586
55BTK0.73836651
56PRKAA20.73345986
57RPS6KA60.72674917
58JAK10.72604699
59CAMK40.71277350
60SIK10.71124168
61PRPF4B0.69581664
62GRK50.63263487
63PIK3CA0.62751214
64PAK40.60056315
65EPHA30.56902746
66IKBKE0.56129463
67CSK0.55275199
68PRKCH0.52813869
69LRRK20.52441127
70PDK30.52057669
71PDK40.52057669
72SYK0.51379040
73MUSK0.50349653
74GRK60.48740141
75FGFR30.48344063
76DAPK20.48106584
77LATS10.47787631
78MOS0.47631013
79EEF2K0.47178110
80TRPM70.46900882
81PTK20.46781239
82MAP3K110.46000969
83MAP2K20.42897997
84TAOK10.42802391
85AKT30.42060692
86MAPKAPK30.41183614
87MAP3K70.40014165
88PDK10.39394864
89TBK10.38970727
90MAPK70.38839742
91MAP3K140.38723823
92JAK20.38551416
93PDPK10.38084060
94TESK10.37723128
95JAK30.37594285
96MAPK150.37013912
97ROCK20.36573379
98SGK20.36309620
99LCK0.36175608
100ILK0.36052355
101STK380.35938185
102MET0.35178419
103PRKCE0.33752082
104MAP3K10.33074579
105FLT30.32907570
106STK100.32414224
107PRKAA10.31450478
108IGF1R0.31033083
109ROCK10.30631777
110PAK30.30584727
111EGFR0.30319618
112TYK20.29497758
113GSK3A0.29245124
114PRKD30.28149296
115NEK90.27890068
116FGFR20.27670916
117PRKD20.27528294
118SRC0.27501959
119PDGFRB0.27301981
120MAP2K10.27114631
121RET0.26359438
122ICK0.26107222
123MTOR0.25545976
124PAK20.23851893
125LATS20.23672750
126MAP4K10.22907369
127NLK0.21986181
128MAP3K100.21380914
129CAMK10.19227982
130MAPK40.18208397
131PINK10.18142735
132SGK30.16828238
133ITK0.16675824
134INSR0.13840011
135MARK30.13557077
136FGFR10.13488512
137STK240.13048107
138GRK70.12631709
139DAPK30.12181303

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.53909257
2Fatty acid degradation_Homo sapiens_hsa000712.47448332
3PPAR signaling pathway_Homo sapiens_hsa033202.42726569
4Complement and coagulation cascades_Homo sapiens_hsa046102.32487115
5Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.30539245
6Propanoate metabolism_Homo sapiens_hsa006402.24042677
7ECM-receptor interaction_Homo sapiens_hsa045122.19738696
8Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.18972222
92-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.17826962
10Arginine biosynthesis_Homo sapiens_hsa002202.11901851
11* Dilated cardiomyopathy_Homo sapiens_hsa054142.09608032
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.05497874
13Focal adhesion_Homo sapiens_hsa045101.94436069
14Glycosaminoglycan degradation_Homo sapiens_hsa005311.93212183
15Nitrogen metabolism_Homo sapiens_hsa009101.86440014
16Fatty acid metabolism_Homo sapiens_hsa012121.74297091
17Adherens junction_Homo sapiens_hsa045201.74061561
18Malaria_Homo sapiens_hsa051441.68614515
19Leukocyte transendothelial migration_Homo sapiens_hsa046701.66022177
20Tryptophan metabolism_Homo sapiens_hsa003801.64165793
21Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.63423620
22Caffeine metabolism_Homo sapiens_hsa002321.63207824
23AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.60027961
24Primary bile acid biosynthesis_Homo sapiens_hsa001201.51521491
25Other glycan degradation_Homo sapiens_hsa005111.46769161
26Staphylococcus aureus infection_Homo sapiens_hsa051501.45407775
27Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.36550417
28* Bile secretion_Homo sapiens_hsa049761.32841073
29Insulin resistance_Homo sapiens_hsa049311.30298518
30HIF-1 signaling pathway_Homo sapiens_hsa040661.22877606
31Olfactory transduction_Homo sapiens_hsa047401.22760502
32Viral myocarditis_Homo sapiens_hsa054161.20625923
33alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.17538918
34Adipocytokine signaling pathway_Homo sapiens_hsa049201.16537619
35Notch signaling pathway_Homo sapiens_hsa043301.16087805
36Amoebiasis_Homo sapiens_hsa051461.12739951
37* Ovarian steroidogenesis_Homo sapiens_hsa049131.10647392
38Dorso-ventral axis formation_Homo sapiens_hsa043201.07865882
39Leishmaniasis_Homo sapiens_hsa051401.07860497
40* Rap1 signaling pathway_Homo sapiens_hsa040151.07739990
41Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.06899828
42* Phospholipase D signaling pathway_Homo sapiens_hsa040721.06553115
43* Aldosterone synthesis and secretion_Homo sapiens_hsa049251.05916587
44ABC transporters_Homo sapiens_hsa020101.05703325
45African trypanosomiasis_Homo sapiens_hsa051431.05041355
46Small cell lung cancer_Homo sapiens_hsa052221.03072194
47Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.02960627
48Cyanoamino acid metabolism_Homo sapiens_hsa004601.01867484
49PI3K-Akt signaling pathway_Homo sapiens_hsa041511.01292856
50Butanoate metabolism_Homo sapiens_hsa006501.00420799
51Circadian rhythm_Homo sapiens_hsa047100.99945020
52Carbon metabolism_Homo sapiens_hsa012000.99433093
53Sulfur relay system_Homo sapiens_hsa041220.99379648
54* GnRH signaling pathway_Homo sapiens_hsa049120.98914700
55Proteoglycans in cancer_Homo sapiens_hsa052050.98772079
56Cardiac muscle contraction_Homo sapiens_hsa042600.98530770
57Linoleic acid metabolism_Homo sapiens_hsa005910.95402912
58Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.94890066
59Tight junction_Homo sapiens_hsa045300.93544352
60Protein digestion and absorption_Homo sapiens_hsa049740.92226601
61* Oxytocin signaling pathway_Homo sapiens_hsa049210.91612955
62Arachidonic acid metabolism_Homo sapiens_hsa005900.89915310
63* Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.87568677
64Glycerophospholipid metabolism_Homo sapiens_hsa005640.87024966
65Fat digestion and absorption_Homo sapiens_hsa049750.86883765
66Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.85715411
67Acute myeloid leukemia_Homo sapiens_hsa052210.84519016
68beta-Alanine metabolism_Homo sapiens_hsa004100.84364257
69Toxoplasmosis_Homo sapiens_hsa051450.83990899
70Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.82999191
71Renin secretion_Homo sapiens_hsa049240.82818112
72Tuberculosis_Homo sapiens_hsa051520.82016808
73Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.81671311
74Peroxisome_Homo sapiens_hsa041460.80754186
75Fatty acid elongation_Homo sapiens_hsa000620.80152909
76* Chemokine signaling pathway_Homo sapiens_hsa040620.79455474
77Pyruvate metabolism_Homo sapiens_hsa006200.78486662
78Starch and sucrose metabolism_Homo sapiens_hsa005000.76401722
79* Longevity regulating pathway - mammal_Homo sapiens_hsa042110.76274022
80Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.75316031
81Lysine degradation_Homo sapiens_hsa003100.74891419
82Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.74246490
83* Platelet activation_Homo sapiens_hsa046110.72257053
84Histidine metabolism_Homo sapiens_hsa003400.71934462
85* Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.71809079
86Vitamin digestion and absorption_Homo sapiens_hsa049770.71290098
87Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.70061588
88VEGF signaling pathway_Homo sapiens_hsa043700.69981085
89* cAMP signaling pathway_Homo sapiens_hsa040240.69842216
90Hematopoietic cell lineage_Homo sapiens_hsa046400.69102422
91B cell receptor signaling pathway_Homo sapiens_hsa046620.67599828
92Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.66934808
93* Vascular smooth muscle contraction_Homo sapiens_hsa042700.65877164
94Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.65588343
95* cGMP-PKG signaling pathway_Homo sapiens_hsa040220.65285651
96Toll-like receptor signaling pathway_Homo sapiens_hsa046200.64235944
97TGF-beta signaling pathway_Homo sapiens_hsa043500.63449532
98Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.63231702
99Renal cell carcinoma_Homo sapiens_hsa052110.62592766
100Phenylalanine metabolism_Homo sapiens_hsa003600.62273854
101Cocaine addiction_Homo sapiens_hsa050300.61478308
102NF-kappa B signaling pathway_Homo sapiens_hsa040640.61206148
103Phagosome_Homo sapiens_hsa041450.61187870
104AMPK signaling pathway_Homo sapiens_hsa041520.61036725
105* Calcium signaling pathway_Homo sapiens_hsa040200.59308247
106* Estrogen signaling pathway_Homo sapiens_hsa049150.58790163
107Arginine and proline metabolism_Homo sapiens_hsa003300.57938822
108Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.57786126
109Glucagon signaling pathway_Homo sapiens_hsa049220.57529638
110Lysosome_Homo sapiens_hsa041420.56908347
111Ras signaling pathway_Homo sapiens_hsa040140.56597620
112Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.55812564
113* Gastric acid secretion_Homo sapiens_hsa049710.55717938
114MAPK signaling pathway_Homo sapiens_hsa040100.54707067
115Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.54298067
116TNF signaling pathway_Homo sapiens_hsa046680.53964969
117Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.52290746
118Regulation of actin cytoskeleton_Homo sapiens_hsa048100.51998770
119Fatty acid biosynthesis_Homo sapiens_hsa000610.51598252
120* Pancreatic secretion_Homo sapiens_hsa049720.50689885
121Insulin signaling pathway_Homo sapiens_hsa049100.50564867
122Choline metabolism in cancer_Homo sapiens_hsa052310.50225704
123Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.49561750
124* Pathways in cancer_Homo sapiens_hsa052000.49058345
125* Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.46838299
126Axon guidance_Homo sapiens_hsa043600.46779127
127Sulfur metabolism_Homo sapiens_hsa009200.46558709
128FoxO signaling pathway_Homo sapiens_hsa040680.46270897
129Intestinal immune network for IgA production_Homo sapiens_hsa046720.45091544
130Graft-versus-host disease_Homo sapiens_hsa053320.44979991
131* Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.44675048
132Allograft rejection_Homo sapiens_hsa053300.44174992
133* Circadian entrainment_Homo sapiens_hsa047130.43684059
134Pertussis_Homo sapiens_hsa051330.43241914
135Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.41792600
136Hepatitis C_Homo sapiens_hsa051600.38059648
137Pentose and glucuronate interconversions_Homo sapiens_hsa000400.35619684
138Osteoclast differentiation_Homo sapiens_hsa043800.35564172
139Rheumatoid arthritis_Homo sapiens_hsa053230.35460014
140Chemical carcinogenesis_Homo sapiens_hsa052040.35060628
141Prion diseases_Homo sapiens_hsa050200.34694821
142Thyroid hormone signaling pathway_Homo sapiens_hsa049190.34440998
143Endocytosis_Homo sapiens_hsa041440.33137482
144Jak-STAT signaling pathway_Homo sapiens_hsa046300.31656782
145Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.30651873
146Glycerolipid metabolism_Homo sapiens_hsa005610.29955803
147Tyrosine metabolism_Homo sapiens_hsa003500.29754222

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